# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Atracotoxin PF05353.11 AFZ78905.1 - 0.038 14.1 1.4 0.12 12.4 1.4 1.8 1 0 0 1 1 1 0 Delta Atracotoxin Cyt-b5 PF00173.28 AFZ78907.1 - 5.7e-19 68.0 0.1 9.6e-19 67.3 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain ABC_tran PF00005.27 AFZ78908.1 - 3.7e-28 98.8 0.0 3.4e-14 53.5 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 AFZ78908.1 - 5.4e-06 26.4 1.3 0.095 12.5 0.1 3.1 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 AFZ78908.1 - 4.2e-05 24.0 0.0 0.079 13.3 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 AFZ78908.1 - 6.6e-05 22.6 0.9 0.2 11.5 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_30 PF13604.6 AFZ78908.1 - 0.00074 19.3 0.1 0.63 9.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 AFZ78908.1 - 0.0015 18.3 1.1 0.46 10.1 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 AFZ78908.1 - 0.002 18.1 0.7 0.23 11.3 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase DUF87 PF01935.17 AFZ78908.1 - 0.0033 17.5 3.4 0.088 12.9 0.1 3.0 3 0 0 3 3 3 1 Helicase HerA, central domain AAA_23 PF13476.6 AFZ78908.1 - 0.0037 17.8 4.0 0.84 10.1 1.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 AFZ78908.1 - 0.0065 17.0 0.1 5.9 7.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 AFZ78908.1 - 0.0082 15.4 0.2 3.3 6.9 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin DnaB_C PF03796.15 AFZ78908.1 - 0.0084 15.5 0.0 0.068 12.5 0.0 2.1 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain MMR_HSR1 PF01926.23 AFZ78908.1 - 0.01 15.9 0.2 0.18 11.9 0.1 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_22 PF13401.6 AFZ78908.1 - 0.012 15.9 0.0 3.1 8.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 AFZ78908.1 - 0.017 15.1 0.5 3 7.8 0.1 2.5 2 0 0 2 2 2 0 NACHT domain FtsK_SpoIIIE PF01580.18 AFZ78908.1 - 0.017 14.5 0.6 1.7 7.9 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family MeaB PF03308.16 AFZ78908.1 - 0.021 13.8 0.5 0.05 12.6 0.0 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB T2SSE PF00437.20 AFZ78908.1 - 0.043 12.9 1.0 6.6 5.7 0.1 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein Dynamin_N PF00350.23 AFZ78908.1 - 0.044 13.9 0.3 7.6 6.6 0.0 2.6 2 0 0 2 2 2 0 Dynamin family SbcCD_C PF13558.6 AFZ78908.1 - 0.046 14.0 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit SMC_N PF02463.19 AFZ78908.1 - 0.05 13.0 2.6 0.23 10.9 0.2 2.5 2 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 AFZ78908.1 - 0.055 13.0 0.1 1 8.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 AFZ78908.1 - 0.1 11.8 0.6 1.8 7.7 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain ATP_bind_1 PF03029.17 AFZ78908.1 - 0.12 12.2 0.1 14 5.3 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein NTPase_1 PF03266.15 AFZ78908.1 - 0.14 12.1 0.3 8.1 6.3 0.1 2.4 2 0 0 2 2 2 0 NTPase IstB_IS21 PF01695.17 AFZ78908.1 - 0.15 11.8 0.1 4.9 6.8 0.0 3.0 3 0 0 3 3 2 0 IstB-like ATP binding protein TsaE PF02367.17 AFZ78908.1 - 0.16 12.0 0.7 3.1 7.8 0.1 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rax2 PF12768.7 AFZ78908.1 - 0.32 10.4 1.1 10 5.5 0.0 2.4 2 0 0 2 2 2 0 Cortical protein marker for cell polarity cobW PF02492.19 AFZ78908.1 - 1 8.9 5.0 6.7 6.3 0.1 2.8 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain FAINT PF04385.15 AFZ78909.1 - 3.3e-05 23.8 0.3 0.00028 20.9 0.0 2.5 3 0 0 3 3 3 1 Domain of unknown function, DUF529 PfkB PF00294.24 AFZ78910.1 - 5.6e-25 88.3 0.0 6.7e-25 88.0 0.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Metallophos PF00149.28 AFZ78911.1 - 2.8e-38 132.5 0.2 4.3e-38 131.9 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 AFZ78911.1 - 4.6e-05 23.8 0.3 0.00028 21.3 0.2 2.2 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Metallophos_2 PF12850.7 AFZ78911.1 - 0.06 13.5 0.0 0.086 13.0 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain SLBP_RNA_bind PF15247.6 AFZ78912.1 - 5.4e-23 80.9 1.5 3.1e-22 78.5 0.8 2.3 2 0 0 2 2 2 1 Histone RNA hairpin-binding protein RNA-binding domain tRNA-synt_2b PF00587.25 AFZ78913.1 - 3.2e-26 92.4 1.6 5.3e-26 91.7 1.6 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 AFZ78913.1 - 4.2e-05 23.6 0.1 0.00022 21.3 0.0 2.2 2 0 0 2 2 2 1 Anticodon binding domain Hist_deacetyl PF00850.19 AFZ78914.1 - 3.9e-79 266.3 0.6 5e-79 266.0 0.1 1.4 2 0 0 2 2 2 1 Histone deacetylase domain DUF3038 PF11237.8 AFZ78914.1 - 0.15 12.1 0.0 0.24 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3038) Yippee-Mis18 PF03226.14 AFZ78915.1 - 1e-14 54.6 0.1 1.2e-14 54.3 0.1 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly SelR PF01641.18 AFZ78915.1 - 0.00055 20.0 0.1 0.00071 19.6 0.1 1.2 1 0 0 1 1 1 1 SelR domain DUF2321 PF10083.9 AFZ78915.1 - 0.018 14.7 0.7 0.04 13.5 0.7 1.7 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) zf-Mss51 PF13824.6 AFZ78915.1 - 0.022 14.9 0.3 4.1 7.6 0.0 2.2 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 DUF678 PF05077.12 AFZ78915.1 - 0.15 12.2 0.1 23 5.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF678) Thioredoxin PF00085.20 AFZ78916.1 - 1.9e-21 76.0 0.6 2.4e-21 75.7 0.6 1.1 1 0 0 1 1 1 1 Thioredoxin Glutaredoxin PF00462.24 AFZ78916.1 - 3.1e-05 24.1 0.1 6.2e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_8 PF13905.6 AFZ78916.1 - 3.9e-05 23.9 0.2 8.7e-05 22.8 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin-like DUF953 PF06110.11 AFZ78916.1 - 0.0014 18.2 0.1 0.0018 17.8 0.1 1.3 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) OST3_OST6 PF04756.13 AFZ78916.1 - 0.0022 17.4 0.1 0.0023 17.3 0.1 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family TraF PF13728.6 AFZ78916.1 - 0.008 16.0 0.0 0.0099 15.7 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein Redoxin PF08534.10 AFZ78916.1 - 0.011 15.5 0.1 0.013 15.2 0.1 1.2 1 0 0 1 1 1 0 Redoxin Thioredoxin_3 PF13192.6 AFZ78916.1 - 0.012 15.6 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin domain AhpC-TSA PF00578.21 AFZ78916.1 - 0.024 14.5 0.1 0.033 14.1 0.1 1.2 1 0 0 1 1 1 0 AhpC/TSA family V-ATPase_C PF03223.15 AFZ78917.1 - 6.1e-76 256.2 1.8 6.8e-76 256.1 1.8 1.0 1 0 0 1 1 1 1 V-ATPase subunit C DUF1039 PF06287.11 AFZ78917.1 - 0.076 13.5 0.1 0.44 11.0 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1039) BRCT_2 PF16589.5 AFZ78918.1 - 0.0042 17.5 0.0 0.024 15.1 0.0 2.3 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain RAWUL PF16207.5 AFZ78918.1 - 0.021 15.5 0.2 0.064 13.9 0.2 1.8 1 0 0 1 1 1 0 RAWUL domain RING finger- and WD40-associated ubiquitin-like DUF3206 PF11472.8 AFZ78918.1 - 0.046 13.7 0.2 0.55 10.2 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3206) FlaC_arch PF05377.11 AFZ78919.1 - 0.029 14.8 0.0 8.7 6.8 0.0 3.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) MMR_HSR1 PF01926.23 AFZ78920.1 - 5.6e-16 58.7 0.0 1.3e-15 57.5 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AFZ78920.1 - 2.7e-09 36.7 0.0 9.7e-08 31.7 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 AFZ78920.1 - 3.4e-08 33.6 0.1 1.3e-07 31.7 0.1 1.9 1 1 0 1 1 1 1 RsgA GTPase Arf PF00025.21 AFZ78920.1 - 0.00078 18.9 0.0 0.039 13.4 0.0 2.5 3 0 0 3 3 3 1 ADP-ribosylation factor family Dynamin_N PF00350.23 AFZ78920.1 - 0.0029 17.7 0.1 0.011 15.8 0.1 1.9 1 1 1 2 2 2 1 Dynamin family PND PF17949.1 AFZ78920.1 - 0.0041 17.4 0.0 0.007 16.6 0.0 1.4 1 0 0 1 1 1 1 FANCM pseudonuclease domain AAA_18 PF13238.6 AFZ78920.1 - 0.0057 17.2 0.0 0.011 16.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain AIG1 PF04548.16 AFZ78920.1 - 0.0061 15.9 0.0 0.014 14.8 0.0 1.5 2 0 0 2 2 2 1 AIG1 family Ras PF00071.22 AFZ78920.1 - 0.011 15.4 0.0 0.48 10.0 0.0 2.2 2 0 0 2 2 2 0 Ras family PTS_2-RNA PF01885.16 AFZ78920.1 - 0.057 13.5 0.0 0.091 12.8 0.0 1.3 1 0 0 1 1 1 0 RNA 2'-phosphotransferase, Tpt1 / KptA family Roc PF08477.13 AFZ78920.1 - 0.075 13.2 0.0 0.23 11.7 0.0 1.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 AFZ78920.1 - 0.12 12.7 0.0 0.24 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain cobW PF02492.19 AFZ78920.1 - 0.16 11.5 0.1 2.9 7.5 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.17 AFZ78920.1 - 0.17 11.6 0.0 6.9 6.4 0.0 2.5 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein TED PF08341.11 AFZ78921.1 - 0.051 14.0 0.0 0.24 11.8 0.0 2.0 2 0 0 2 2 2 0 Thioester domain HECT PF00632.25 AFZ78922.1 - 4.5e-98 328.5 0.2 7.5e-98 327.8 0.2 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF2458 PF10454.9 AFZ78922.1 - 0.088 12.5 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) PH_11 PF15413.6 AFZ78923.1 - 0.049 14.1 0.2 13 6.2 0.0 3.3 2 0 0 2 2 2 0 Pleckstrin homology domain tRNA_anti-codon PF01336.25 AFZ78924.1 - 0.016 15.2 0.1 0.025 14.5 0.1 1.4 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain DELLA PF12041.8 AFZ78924.1 - 0.058 13.3 0.0 0.96 9.4 0.0 2.6 2 0 0 2 2 2 0 Transcriptional regulator DELLA protein N terminal SNF5 PF04855.12 AFZ78925.1 - 2.3e-06 27.6 6.1 0.0064 16.3 0.2 2.4 2 0 0 2 2 2 2 SNF5 / SMARCB1 / INI1 Telomere_reg-2 PF10193.9 AFZ78925.1 - 0.0051 17.2 1.0 0.13 12.8 0.0 2.9 2 0 0 2 2 2 1 Telomere length regulation protein Choline_kinase PF01633.20 AFZ78926.1 - 9.5e-30 103.8 0.0 1.6e-29 103.1 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 AFZ78926.1 - 2.2e-09 37.6 0.0 3.3e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 AFZ78927.1 - 1.4e-24 86.9 0.0 2.2e-24 86.2 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 AFZ78927.1 - 2e-07 31.2 0.0 2.9e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 AFZ78927.1 - 0.0041 16.5 0.1 0.0068 15.8 0.1 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase FAINT PF04385.15 AFZ78928.1 - 2.5e-12 46.7 1.1 6.3e-06 26.2 0.1 3.4 3 0 0 3 3 3 3 Domain of unknown function, DUF529 PSI_PsaE PF02427.17 AFZ78928.1 - 0.098 12.3 0.1 0.32 10.7 0.1 1.8 1 0 0 1 1 1 0 Photosystem I reaction centre subunit IV / PsaE Hydrolase_3 PF08282.12 AFZ78929.1 - 1.2e-36 126.7 0.0 1.5e-36 126.4 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 AFZ78929.1 - 0.00014 21.5 0.0 0.02 14.4 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase LpxC PF03331.13 AFZ78929.1 - 0.031 13.8 0.0 0.051 13.1 0.0 1.3 1 0 0 1 1 1 0 UDP-3-O-acyl N-acetylglycosamine deacetylase HAD PF12710.7 AFZ78929.1 - 0.069 13.5 0.0 1.8 8.9 0.0 2.3 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 AFZ78929.1 - 0.095 12.8 0.0 0.64 10.1 0.0 2.0 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Pribosyltran PF00156.27 AFZ78930.1 - 4.9e-10 39.2 0.0 8.1e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PfkB PF00294.24 AFZ78931.1 - 5.6e-25 88.3 0.0 6.7e-25 88.0 0.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Pribosyltran PF00156.27 AFZ78932.1 - 1.3e-15 57.3 0.0 1.8e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 AFZ78932.1 - 0.063 12.7 0.0 0.2 11.1 0.0 1.8 2 0 0 2 2 2 0 Uracil phosphoribosyltransferase Carboxyl_trans PF01039.22 AFZ78932.1 - 0.12 11.0 0.0 3.3 6.2 0.0 2.0 2 0 0 2 2 2 0 Carboxyl transferase domain Histone PF00125.24 AFZ78933.1 - 6.8e-21 75.0 3.6 1.1e-20 74.3 0.2 2.1 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 AFZ78933.1 - 0.031 14.4 0.0 0.052 13.7 0.0 1.3 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 AFZ78933.1 - 0.09 13.1 0.4 0.23 11.8 0.4 1.7 1 1 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone COX5B PF01215.19 AFZ78934.1 - 2.1e-11 43.6 0.0 3.7e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb Aminotran_1_2 PF00155.21 AFZ78935.1 - 4e-56 190.8 0.0 4.5e-56 190.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II UPF0058 PF01893.16 AFZ78935.1 - 0.083 13.2 0.6 0.35 11.2 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0058 Ribosomal_L25p PF01386.19 AFZ78936.1 - 0.00029 21.3 0.0 0.0011 19.5 0.0 1.9 1 1 1 2 2 2 1 Ribosomal L25p family Ribosomal_TL5_C PF14693.6 AFZ78936.1 - 0.00061 20.1 0.0 0.0012 19.2 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein TL5, C-terminal domain Pro_isomerase PF00160.21 AFZ78937.1 - 9.4e-43 146.2 1.1 1.1e-42 145.9 1.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD NTF2 PF02136.20 AFZ78938.1 - 3.5e-26 92.1 0.0 3.9e-26 92.0 0.0 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain SnoaL_2 PF12680.7 AFZ78938.1 - 0.19 12.4 0.0 0.21 12.2 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like domain PIP5K PF01504.18 AFZ78940.1 - 1.3e-34 119.7 3.2 8.2e-25 87.6 2.0 2.5 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 AFZ78940.1 - 1.6e-07 30.3 0.0 3.5e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Actin PF00022.19 AFZ78941.1 - 2.4e-110 369.0 0.0 2.9e-108 362.1 0.0 2.0 1 1 0 1 1 1 1 Actin DS PF01916.17 AFZ78942.1 - 8.5e-127 422.3 0.0 9.8e-127 422.1 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase AAA PF00004.29 AFZ78943.1 - 9.2e-81 268.8 0.2 1.1e-46 158.6 0.0 2.6 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AFZ78943.1 - 1.1e-18 66.7 1.1 1.7e-13 50.2 0.2 2.7 2 0 0 2 2 2 2 AAA+ lid domain AAA_5 PF07728.14 AFZ78943.1 - 3.2e-11 43.4 0.1 4.1e-05 23.6 0.0 3.8 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 AFZ78943.1 - 8.3e-10 39.3 0.0 0.013 15.9 0.0 4.5 3 2 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 AFZ78943.1 - 9.9e-09 35.6 0.4 0.00016 22.0 0.0 3.9 3 1 0 3 3 3 2 AAA domain RuvB_N PF05496.12 AFZ78943.1 - 2.2e-08 34.0 0.0 0.00078 19.2 0.0 3.1 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 AFZ78943.1 - 6e-08 33.0 0.0 0.0027 17.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 AFZ78943.1 - 1.5e-07 31.5 0.1 0.0071 16.4 0.1 2.9 3 0 0 3 3 3 2 AAA domain RNA_helicase PF00910.22 AFZ78943.1 - 1.7e-07 31.6 0.1 0.25 11.7 0.0 3.7 3 0 0 3 3 3 2 RNA helicase TIP49 PF06068.13 AFZ78943.1 - 2.7e-07 30.1 0.0 0.017 14.3 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain Mg_chelatase PF01078.21 AFZ78943.1 - 8.5e-06 25.3 0.0 0.036 13.4 0.0 2.7 3 0 0 3 3 2 2 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 AFZ78943.1 - 1.4e-05 24.7 0.0 0.028 13.9 0.0 2.7 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_33 PF13671.6 AFZ78943.1 - 5.9e-05 23.3 0.0 0.12 12.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain ATPase PF06745.13 AFZ78943.1 - 6.2e-05 22.5 1.1 4.4 6.6 0.0 4.0 4 0 0 4 4 4 1 KaiC IstB_IS21 PF01695.17 AFZ78943.1 - 8.2e-05 22.4 0.0 0.18 11.5 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.6 AFZ78943.1 - 0.00029 21.4 0.3 0.064 13.8 0.0 3.1 3 0 0 3 3 2 1 AAA domain NB-ARC PF00931.22 AFZ78943.1 - 0.00056 19.2 0.0 0.029 13.5 0.0 2.7 3 0 0 3 3 3 1 NB-ARC domain ABC_tran PF00005.27 AFZ78943.1 - 0.00086 19.8 0.1 0.22 12.1 0.1 3.1 2 1 0 2 2 2 1 ABC transporter AAA_24 PF13479.6 AFZ78943.1 - 0.0017 18.1 0.1 0.036 13.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 AFZ78943.1 - 0.0018 18.7 0.0 0.29 11.5 0.1 3.1 2 1 1 3 3 3 1 AAA domain AAA_25 PF13481.6 AFZ78943.1 - 0.0028 17.3 0.7 3 7.4 0.0 3.8 3 1 0 4 4 4 1 AAA domain Rad17 PF03215.15 AFZ78943.1 - 0.0046 16.9 0.5 0.083 12.8 0.0 2.9 2 1 0 2 2 2 1 Rad17 P-loop domain NACHT PF05729.12 AFZ78943.1 - 0.0076 16.2 0.0 0.13 12.2 0.0 2.4 2 0 0 2 2 2 1 NACHT domain ATPase_2 PF01637.18 AFZ78943.1 - 0.015 15.2 4.4 4.2 7.2 0.0 4.3 3 2 1 5 5 5 0 ATPase domain predominantly from Archaea TsaE PF02367.17 AFZ78943.1 - 0.036 14.1 0.0 5.5 7.0 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 AFZ78943.1 - 0.052 12.8 0.0 3 7.1 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin Sigma54_activat PF00158.26 AFZ78943.1 - 0.055 13.2 0.0 6.6 6.4 0.0 2.8 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_28 PF13521.6 AFZ78943.1 - 0.069 13.4 0.0 4.1 7.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 AFZ78943.1 - 0.093 12.6 0.0 4.3 7.2 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 AFZ78943.1 - 0.11 12.5 0.3 4.8 7.3 0.1 3.0 3 0 0 3 3 2 0 Vps4 C terminal oligomerisation domain NMT PF01233.19 AFZ78944.1 - 1.7e-73 245.7 0.0 2.6e-73 245.1 0.0 1.3 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C PF02799.15 AFZ78944.1 - 4e-47 160.5 0.2 7.4e-47 159.6 0.2 1.4 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Acetyltransf_9 PF13527.7 AFZ78944.1 - 0.00028 21.0 0.0 0.00083 19.4 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 AFZ78944.1 - 0.00069 19.8 0.0 0.0021 18.2 0.0 1.9 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family CS PF04969.16 AFZ78945.1 - 1e-07 32.9 0.1 2.4e-07 31.7 0.1 1.6 1 0 0 1 1 1 1 CS domain Pyrophosphatase PF00719.19 AFZ78946.1 - 1.4e-40 138.7 0.0 1.9e-40 138.3 0.0 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase Nuf2 PF03800.14 AFZ78948.1 - 1.9e-17 63.6 0.0 5.5e-17 62.2 0.0 1.8 1 0 0 1 1 1 1 Nuf2 family Ribosomal_L9_C PF03948.14 AFZ78948.1 - 0.0016 18.9 0.2 0.0064 16.9 0.0 2.2 2 0 0 2 2 2 1 Ribosomal protein L9, C-terminal domain TPR_MLP1_2 PF07926.12 AFZ78948.1 - 0.0069 16.5 18.0 0.014 15.4 2.1 3.2 2 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein Occludin_ELL PF07303.13 AFZ78948.1 - 1.9 9.3 17.5 0.1 13.3 1.3 3.8 2 1 1 4 4 4 0 Occludin homology domain DUF948 PF06103.11 AFZ78948.1 - 5 7.4 10.5 4.7 7.5 0.2 3.9 3 2 0 3 3 3 0 Bacterial protein of unknown function (DUF948) STAT_alpha PF01017.20 AFZ78948.1 - 6.9 6.5 19.7 0.22 11.4 3.9 2.8 2 1 0 2 2 2 0 STAT protein, all-alpha domain Laminin_II PF06009.12 AFZ78948.1 - 8.9 6.3 19.0 1.3 9.1 3.4 3.6 2 1 2 4 4 4 0 Laminin Domain II Ribosomal_S8 PF00410.19 AFZ78949.1 - 3.2e-19 69.1 0.0 4.8e-19 68.6 0.0 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 TB2_DP1_HVA22 PF03134.19 AFZ78950.1 - 1.6e-20 72.8 3.1 1.6e-20 72.8 3.1 1.8 2 0 0 2 2 2 1 TB2/DP1, HVA22 family DUF2605 PF10792.9 AFZ78950.1 - 0.11 12.5 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2605) DUF4870 PF09685.10 AFZ78950.1 - 0.42 10.7 8.2 0.094 12.8 2.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4870) RRM_1 PF00076.22 AFZ78951.1 - 8.6e-14 51.1 0.0 1.4e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 AFZ78951.1 - 3.2e-05 23.9 0.1 5.6e-05 23.1 0.1 1.4 1 0 0 1 1 1 1 RNA binding motif FYVE PF01363.21 AFZ78952.1 - 2.4e-05 24.4 11.3 2.4e-05 24.4 11.3 2.0 2 0 0 2 2 2 1 FYVE zinc finger DUF3450 PF11932.8 AFZ78952.1 - 0.00062 19.1 10.6 0.011 15.1 4.1 2.5 1 1 2 3 3 3 2 Protein of unknown function (DUF3450) GAS PF13851.6 AFZ78952.1 - 0.0011 18.4 8.9 0.0011 18.4 8.9 2.0 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding DUF812 PF05667.11 AFZ78952.1 - 0.0013 17.7 7.4 0.0017 17.4 7.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) TMF_TATA_bd PF12325.8 AFZ78952.1 - 0.0039 17.4 5.9 0.0039 17.4 5.9 2.7 2 1 1 3 3 3 1 TATA element modulatory factor 1 TATA binding TPR_MLP1_2 PF07926.12 AFZ78952.1 - 0.0076 16.3 6.1 0.016 15.3 6.1 1.4 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein DUF1843 PF08898.10 AFZ78952.1 - 0.014 15.9 0.3 0.026 15.0 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1843) HemX PF04375.14 AFZ78952.1 - 0.068 12.5 5.4 0.11 11.8 5.4 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DivIVA PF05103.13 AFZ78952.1 - 0.075 13.1 11.1 1 9.5 4.3 3.0 2 1 1 3 3 3 0 DivIVA protein Spc7 PF08317.11 AFZ78952.1 - 0.094 11.6 8.5 0.17 10.8 8.5 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Helitron_like_N PF14214.6 AFZ78952.1 - 0.1 12.8 2.3 0.18 12.0 2.3 1.3 1 0 0 1 1 1 0 Helitron helicase-like domain at N-terminus ATG16 PF08614.11 AFZ78952.1 - 0.15 12.2 13.5 0.061 13.5 10.3 1.7 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) CENP-Q PF13094.6 AFZ78952.1 - 0.3 11.3 7.2 0.031 14.5 2.6 1.6 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit TMPIT PF07851.13 AFZ78952.1 - 0.36 10.0 6.6 0.69 9.1 6.6 1.4 1 0 0 1 1 1 0 TMPIT-like protein DUF4200 PF13863.6 AFZ78952.1 - 0.37 11.2 14.9 0.21 12.0 8.6 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) V_ATPase_I PF01496.19 AFZ78952.1 - 0.42 8.5 4.4 0.56 8.1 4.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CENP-F_leu_zip PF10473.9 AFZ78952.1 - 0.62 10.1 18.1 0.11 12.5 13.7 2.0 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 NPV_P10 PF05531.12 AFZ78952.1 - 0.65 10.5 4.3 0.6 10.6 0.8 2.6 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Tox-ODYAM1 PF15642.6 AFZ78952.1 - 0.95 8.4 6.3 1.3 7.9 6.3 1.2 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus Cauli_AT PF03233.13 AFZ78952.1 - 1.1 9.2 8.5 0.096 12.6 3.5 1.8 2 1 0 2 2 1 0 Aphid transmission protein DUF745 PF05335.13 AFZ78952.1 - 1.4 8.6 5.2 2.2 7.9 5.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF745) GrpE PF01025.19 AFZ78952.1 - 1.8 8.2 13.2 0.2 11.3 1.3 2.8 2 1 1 3 3 3 0 GrpE COG2 PF06148.11 AFZ78952.1 - 2.1 8.4 11.1 0.43 10.7 6.6 2.1 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 HIP1_clath_bdg PF16515.5 AFZ78952.1 - 2.3 8.9 15.5 2.4 8.8 9.0 2.8 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Med9 PF07544.13 AFZ78952.1 - 4.6 7.4 12.9 1.3 9.1 7.7 2.7 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 KIF1B PF12423.8 AFZ78952.1 - 6.4 7.3 6.5 12 6.4 2.3 2.5 2 0 0 2 2 2 0 Kinesin protein 1B DUF1664 PF07889.12 AFZ78952.1 - 7.7 6.6 9.9 0.63 10.1 1.1 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DivIC PF04977.15 AFZ78952.1 - 8.6 6.2 12.3 0.4 10.5 0.4 3.0 2 1 1 3 3 3 0 Septum formation initiator UPF0242 PF06785.11 AFZ78952.1 - 8.7 6.4 16.4 2.7 8.0 11.7 2.0 1 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus SlyX PF04102.12 AFZ78952.1 - 9.9 6.9 7.7 2.5e+03 -0.9 7.7 3.1 1 1 0 1 1 1 0 SlyX DUF1192 PF06698.11 AFZ78954.1 - 0.084 12.9 1.2 0.61 10.2 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) HMMR_N PF15905.5 AFZ78954.1 - 0.19 11.2 61.1 0.16 11.4 22.1 3.1 1 1 2 3 3 3 0 Hyaluronan mediated motility receptor N-terminal DUF3584 PF12128.8 AFZ78954.1 - 0.31 8.5 41.9 0.45 8.0 41.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) MscS_porin PF12795.7 AFZ78954.1 - 0.42 10.1 36.7 0.055 13.0 15.9 3.2 2 1 0 2 2 2 0 Mechanosensitive ion channel porin domain Lipoprotein_7 PF01540.16 AFZ78954.1 - 0.58 9.4 34.6 0.68 9.2 27.1 2.3 1 1 1 2 2 2 0 Adhesin lipoprotein Mce4_CUP1 PF11887.8 AFZ78954.1 - 0.62 9.5 3.6 2 7.8 0.3 2.3 2 0 0 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative TACC_C PF05010.14 AFZ78954.1 - 0.91 9.3 55.0 0.63 9.8 22.0 3.3 1 1 2 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF812 PF05667.11 AFZ78954.1 - 2.5 6.9 51.9 0.63 8.9 36.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF812) CALCOCO1 PF07888.11 AFZ78954.1 - 2.6 6.8 48.7 2.6 6.8 18.4 2.1 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like ERM PF00769.19 AFZ78954.1 - 5 6.9 49.8 6 6.6 19.5 2.9 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF1515 PF07439.11 AFZ78954.1 - 8 6.5 18.4 1.8 8.6 1.0 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1515) FlaC_arch PF05377.11 AFZ78954.1 - 8.6 6.8 21.5 10 6.6 0.9 4.8 2 2 1 4 4 4 0 Flagella accessory protein C (FlaC) ER PF01133.17 AFZ78955.1 - 0.011 15.7 1.8 0.026 14.5 0.4 2.1 2 0 0 2 2 2 0 Enhancer of rudimentary UPF0020 PF01170.18 AFZ78956.1 - 0.00097 18.9 0.0 1.5 8.5 0.0 2.4 2 0 0 2 2 2 2 Putative RNA methylase family UPF0020 DXP_reductoisom PF02670.16 AFZ78957.1 - 5.9e-36 124.0 0.4 1e-35 123.3 0.4 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase DXP_redisom_C PF08436.12 AFZ78957.1 - 1.4e-33 114.9 0.1 3e-33 113.8 0.1 1.6 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain DXPR_C PF13288.6 AFZ78957.1 - 4.7e-32 110.7 0.0 8e-32 109.9 0.0 1.4 1 0 0 1 1 1 1 DXP reductoisomerase C-terminal domain Semialdhyde_dh PF01118.24 AFZ78957.1 - 0.092 13.2 0.0 0.21 12.1 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Pep3_Vps18 PF05131.14 AFZ78959.1 - 1.3e-14 54.2 0.1 3.4e-14 52.9 0.1 1.7 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family Vps39_2 PF10367.9 AFZ78959.1 - 5.2e-07 30.1 0.5 1.4e-06 28.7 0.2 1.9 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 RasGAP PF00616.19 AFZ78959.1 - 0.00021 21.1 0.2 0.00042 20.1 0.2 1.5 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase zf-C3HC4_2 PF13923.6 AFZ78959.1 - 0.00098 18.9 1.0 0.00098 18.9 1.0 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AFZ78959.1 - 0.003 17.6 0.4 0.012 15.6 0.4 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 AFZ78959.1 - 0.011 16.0 1.0 0.011 16.0 1.0 2.4 2 0 0 2 2 2 0 Ring finger domain zf-RING_11 PF17123.5 AFZ78959.1 - 0.012 15.3 4.5 0.012 15.3 4.5 2.5 2 0 0 2 2 2 0 RING-like zinc finger zf-C3HC4 PF00097.25 AFZ78959.1 - 0.034 14.0 0.5 0.15 11.9 0.5 2.1 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 AFZ78959.1 - 0.15 12.4 0.9 0.57 10.5 0.9 2.1 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_5 PF14634.6 AFZ78959.1 - 4.2 7.4 7.0 1.4 9.0 2.1 2.7 2 1 1 3 3 3 0 zinc-RING finger domain SANT_DAMP1_like PF16282.5 AFZ78960.1 - 0.001 19.2 0.3 0.001 19.2 0.3 1.8 2 0 0 2 2 2 1 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_6 PF13921.6 AFZ78960.1 - 0.0028 17.9 0.6 0.0077 16.5 0.6 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain IGR PF09597.10 AFZ78960.1 - 0.05 13.7 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 IGR protein motif zf-SNAP50_C PF12251.8 AFZ78961.1 - 1.3e-40 139.2 3.7 1.3e-40 139.2 3.7 1.6 2 0 0 2 2 2 1 snRNA-activating protein of 50kDa MW C terminal DUF2197 PF09963.9 AFZ78961.1 - 0.018 15.3 1.6 0.018 15.3 1.6 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2197) Ribosomal_L27e PF01777.18 AFZ78962.1 - 4.3e-28 97.5 7.3 5.6e-28 97.1 7.3 1.1 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 AFZ78962.1 - 0.0039 17.1 0.0 0.007 16.3 0.0 1.4 1 0 0 1 1 1 1 KOW motif ENTH PF01417.20 AFZ78963.1 - 1.1e-05 25.5 3.1 0.00088 19.3 0.2 2.7 2 1 0 2 2 2 2 ENTH domain RasGEF_N PF00618.20 AFZ78963.1 - 0.11 12.8 0.2 1.5 9.1 0.0 2.6 2 0 0 2 2 2 0 RasGEF N-terminal motif Ribosomal_L29e PF01779.17 AFZ78965.1 - 1.2e-20 73.5 12.9 1.2e-20 73.5 12.9 1.6 2 0 0 2 2 2 1 Ribosomal L29e protein family ECR1_N PF14382.6 AFZ78966.1 - 1e-07 31.6 0.0 2.2e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 AFZ78966.1 - 1.8e-07 31.4 0.1 4.6e-07 30.1 0.1 1.8 1 0 0 1 1 1 1 KH domain Ribosomal_L5e PF17144.4 AFZ78967.1 - 4.2e-80 267.5 0.3 4.2e-80 267.5 0.3 2.1 2 0 0 2 2 2 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 AFZ78967.1 - 3e-31 108.2 5.6 8.3e-31 106.8 5.6 1.8 1 0 0 1 1 1 1 Ribosomal L18 C-terminal region DUF1476 PF07345.11 AFZ78967.1 - 0.009 16.4 0.1 0.049 14.0 0.0 2.2 2 0 0 2 2 2 1 ATPase inhibitor subunit zeta Ribosomal_L7Ae PF01248.26 AFZ78968.1 - 9.4e-22 76.6 0.4 2.1e-21 75.5 0.4 1.6 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF2624 PF11116.8 AFZ78968.1 - 0.064 14.1 0.2 0.16 12.9 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2624) Las1 PF04031.13 AFZ78970.1 - 1.6e-30 106.2 0.1 3.2e-30 105.3 0.1 1.4 1 0 0 1 1 1 1 Las1-like zf-CCCH PF00642.24 AFZ78971.1 - 1.4e-09 37.6 8.5 2.9e-06 27.0 0.8 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 AFZ78971.1 - 0.00011 22.4 6.4 0.016 15.4 0.7 2.4 1 1 1 2 2 2 2 Zinc-finger containing family zf_CCCH_4 PF18345.1 AFZ78971.1 - 0.0015 18.5 16.8 0.25 11.5 5.8 3.4 2 1 0 2 2 2 2 Zinc finger domain zf-CCCH_2 PF14608.6 AFZ78971.1 - 0.0052 17.2 0.6 0.0052 17.2 0.6 2.6 2 0 0 2 2 2 1 RNA-binding, Nab2-type zinc finger Torus PF16131.5 AFZ78971.1 - 0.0074 17.0 8.3 0.35 11.6 1.5 2.5 1 1 1 2 2 2 2 Torus domain zf-CCCH_4 PF18044.1 AFZ78971.1 - 0.13 12.1 13.8 1 9.3 2.7 3.0 2 1 0 2 2 2 0 CCCH-type zinc finger zf-C3H1 PF10650.9 AFZ78971.1 - 3.5 7.4 5.5 0.47 10.2 0.9 1.9 2 0 0 2 2 2 0 Putative zinc-finger domain PrmA PF06325.13 AFZ78972.1 - 1.1e-11 44.7 0.1 1.8e-11 44.0 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 AFZ78972.1 - 1.9e-11 44.5 0.0 9.6e-11 42.2 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AFZ78972.1 - 2.1e-09 37.9 0.0 7.3e-09 36.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 AFZ78972.1 - 2.1e-08 34.1 0.2 4.2e-08 33.1 0.2 1.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AFZ78972.1 - 2.1e-06 27.4 0.3 3.6e-06 26.6 0.3 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 AFZ78972.1 - 3.1e-06 27.1 0.0 5.5e-06 26.3 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AFZ78972.1 - 2.4e-05 25.0 0.0 5.3e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 AFZ78972.1 - 5.3e-05 23.2 0.1 9.6e-05 22.3 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 AFZ78972.1 - 7.2e-05 21.9 0.0 0.0001 21.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) TehB PF03848.14 AFZ78972.1 - 0.00083 18.8 0.2 0.00083 18.8 0.2 1.6 2 0 0 2 2 2 1 Tellurite resistance protein TehB Methyltransf_16 PF10294.9 AFZ78972.1 - 0.0019 18.0 0.9 0.0027 17.5 0.2 1.6 2 0 0 2 2 2 1 Lysine methyltransferase PRMT5 PF05185.16 AFZ78972.1 - 0.0032 17.3 0.1 0.0076 16.1 0.1 1.6 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase CMAS PF02353.20 AFZ78972.1 - 0.0063 15.8 0.1 0.0093 15.3 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.6 AFZ78972.1 - 0.019 14.9 0.0 0.029 14.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DUF4985 PF16373.5 AFZ78972.1 - 0.023 15.1 0.3 0.046 14.2 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function Cons_hypoth95 PF03602.15 AFZ78972.1 - 0.024 14.3 0.0 0.13 11.8 0.0 2.0 2 0 0 2 2 2 0 Conserved hypothetical protein 95 Methyltransf_15 PF09445.10 AFZ78972.1 - 0.067 12.8 0.2 0.13 11.8 0.2 1.5 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Ribosomal_L21e PF01157.18 AFZ78973.1 - 9.3e-43 144.2 2.3 9.3e-43 144.2 2.3 1.4 2 0 0 2 2 2 1 Ribosomal protein L21e NAC PF01849.18 AFZ78974.1 - 2.1e-19 69.2 0.0 3.5e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 NAC domain WW PF00397.26 AFZ78975.1 - 2.3e-06 27.6 0.4 6.6e-06 26.1 0.4 1.8 1 0 0 1 1 1 1 WW domain Ribosomal_L16 PF00252.18 AFZ78976.1 - 3e-41 140.5 0.1 3.9e-41 140.2 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e ribosomal_L24 PF17136.4 AFZ78977.1 - 9.2e-14 51.6 0.1 2e-13 50.5 0.1 1.6 1 0 0 1 1 1 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.29 AFZ78977.1 - 0.00017 21.4 0.7 0.0003 20.6 0.7 1.4 1 0 0 1 1 1 1 KOW motif Rep_fac-A_C PF08646.10 AFZ78978.1 - 2.3e-28 98.8 0.0 4.4e-28 97.9 0.0 1.4 1 0 0 1 1 1 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 AFZ78978.1 - 7.2e-23 80.4 2.5 1.6e-22 79.3 2.5 1.6 1 0 0 1 1 1 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 AFZ78978.1 - 3.9e-11 42.8 0.2 2.6e-08 33.7 0.0 3.2 2 1 1 3 3 3 2 OB-fold nucleic acid binding domain DUF4503 PF14951.6 AFZ78978.1 - 0.025 13.0 0.2 0.058 11.9 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4503) DnaJ_C PF01556.18 AFZ78979.1 - 1.1e-34 119.7 0.0 1.5e-34 119.2 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 AFZ78979.1 - 1.2e-23 82.9 0.9 2.3e-23 82.1 0.9 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 AFZ78979.1 - 6.3e-10 39.3 12.2 6.3e-10 39.3 12.2 1.9 2 0 0 2 2 2 1 DnaJ central domain Transcrip_act PF04949.13 AFZ78979.1 - 0.054 13.4 0.0 0.09 12.7 0.0 1.2 1 0 0 1 1 1 0 Transcriptional activator HypA PF01155.19 AFZ78979.1 - 2.7 8.1 7.7 2.6 8.1 0.9 2.5 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Peptidase_C1 PF00112.23 AFZ78980.1 - 2.4e-54 184.7 7.7 4e-54 184.0 7.7 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 AFZ78980.1 - 1.6e-07 31.6 3.0 4.5e-07 30.2 3.0 1.8 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 AFZ78980.1 - 3.2e-06 26.2 2.2 5.7e-06 25.4 0.9 1.9 2 0 0 2 2 2 1 Peptidase C1-like family zf-C2H2_2 PF12756.7 AFZ78981.1 - 7.3e-25 87.2 6.8 2e-22 79.4 2.4 2.7 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 AFZ78981.1 - 5.7e-07 29.7 7.4 0.0028 17.9 0.9 2.8 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 AFZ78981.1 - 0.0013 19.4 4.4 0.28 12.1 0.2 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 AFZ78981.1 - 0.11 12.9 7.8 0.31 11.5 0.7 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 AFZ78981.1 - 0.22 12.0 9.2 0.33 11.5 0.8 3.2 3 0 0 3 3 3 0 Zinc finger, C2H2 type HNH PF01844.23 AFZ78981.1 - 1.4 9.2 4.0 1 9.6 1.3 2.3 2 0 0 2 2 2 0 HNH endonuclease DNA_pol_A_exo1 PF01612.20 AFZ78982.1 - 9.5e-20 71.0 0.1 1.4e-19 70.5 0.1 1.2 1 0 0 1 1 1 1 3'-5' exonuclease DUF3985 PF13153.6 AFZ78982.1 - 0.27 11.3 0.2 0.27 11.3 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3985) HTH_22 PF13309.6 AFZ78983.1 - 0.071 13.2 1.0 0.48 10.6 0.1 2.4 2 0 0 2 2 2 0 HTH domain YIF1 PF03878.15 AFZ78984.1 - 8.3e-10 38.6 8.0 3e-06 26.9 0.7 2.4 1 1 1 2 2 2 2 YIF1 MitoNEET_N PF10660.9 AFZ78984.1 - 0.053 13.5 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus LSM PF01423.22 AFZ78985.1 - 1.6e-17 62.9 0.1 2.1e-17 62.6 0.1 1.2 1 0 0 1 1 1 1 LSM domain AMP-binding PF00501.28 AFZ78986.1 - 4.1e-67 226.6 0.0 5.4e-67 226.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 AFZ78986.1 - 0.0015 19.4 0.6 0.0042 18.0 0.6 1.8 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain JUPITER PF17054.5 AFZ78988.1 - 0.015 14.7 0.0 0.016 14.7 0.0 1.0 1 0 0 1 1 1 0 Microtubule-Associated protein Jupiter HUN PF08729.10 AFZ78989.1 - 3.3e-09 36.6 2.9 3.3e-09 36.6 2.9 2.8 3 0 0 3 3 3 1 HPC2 and ubinuclein domain DNA_repr_REX1B PF14966.6 AFZ78989.1 - 0.071 13.8 1.0 0.58 10.9 1.0 2.6 1 1 0 1 1 1 0 DNA repair REX1-B MCM PF00493.23 AFZ78991.1 - 4.2e-98 326.9 0.0 7.3e-98 326.1 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 AFZ78991.1 - 2.5e-33 114.6 0.5 7.6e-33 113.1 0.1 1.9 2 0 0 2 2 2 1 MCM OB domain MCM_lid PF17855.1 AFZ78991.1 - 2.8e-25 88.6 0.3 6.1e-25 87.5 0.3 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM6_C PF18263.1 AFZ78991.1 - 2.5e-09 37.3 2.0 5.8e-09 36.2 0.3 2.5 2 0 0 2 2 2 1 MCM6 C-terminal winged-helix domain MCM_N PF14551.6 AFZ78991.1 - 2.5e-06 28.0 6.4 4.1e-06 27.3 2.0 3.1 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 AFZ78991.1 - 0.00012 21.6 0.0 0.0003 20.2 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 AFZ78991.1 - 0.0021 18.1 0.0 0.02 14.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase_C PF13335.6 AFZ78991.1 - 0.079 13.6 0.5 0.49 11.1 0.1 2.5 3 1 0 3 3 3 0 Magnesium chelatase, subunit ChlI C-terminal Desulfoferrod_N PF06397.12 AFZ78991.1 - 0.083 12.5 0.3 0.2 11.3 0.3 1.6 1 0 0 1 1 1 0 Desulfoferrodoxin, N-terminal domain AAA_3 PF07726.11 AFZ78991.1 - 0.17 11.7 0.0 0.41 10.5 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) UCH PF00443.29 AFZ78994.1 - 9.2e-38 130.2 1.3 1.2e-37 129.9 1.3 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AFZ78994.1 - 4e-19 69.4 3.4 1.2e-18 67.8 3.4 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PIG-X PF08320.12 AFZ78995.1 - 4.1e-07 30.1 0.2 0.00015 21.8 0.1 2.3 2 0 0 2 2 2 2 PIG-X / PBN1 DUF1735 PF08522.10 AFZ78995.1 - 0.059 14.0 0.4 0.29 11.7 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF1735) GPHH PF16905.5 AFZ78996.1 - 0.14 12.0 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Voltage-dependent L-type calcium channel, IQ-associated SMC_N PF02463.19 AFZ78997.1 - 1.9e-68 230.2 10.8 5.9e-68 228.6 10.8 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 AFZ78997.1 - 8.1e-24 84.2 0.0 3.1e-23 82.3 0.0 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 AFZ78997.1 - 6.2e-11 42.7 18.9 8.7e-07 29.0 0.3 4.4 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 AFZ78997.1 - 1.8e-10 41.7 19.5 1.8e-10 41.7 19.5 7.3 2 2 3 5 5 2 1 AAA domain AAA_29 PF13555.6 AFZ78997.1 - 6.8e-06 25.7 0.0 1.4e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 AFZ78997.1 - 0.0003 20.6 37.4 0.0003 20.6 37.4 5.7 1 1 3 4 4 1 1 AAA ATPase domain ABC_tran PF00005.27 AFZ78997.1 - 0.05 14.1 0.0 0.05 14.1 0.0 5.9 5 1 0 5 5 4 0 ABC transporter AAA_22 PF13401.6 AFZ78997.1 - 0.064 13.5 0.1 1.5 9.1 0.0 3.3 3 0 0 3 3 3 0 AAA domain TIG_plexin PF17960.1 AFZ78997.1 - 0.12 12.4 0.3 0.4 10.7 0.3 1.9 1 0 0 1 1 1 0 TIG domain ATG16 PF08614.11 AFZ78997.1 - 0.16 12.2 67.7 3.9 7.6 10.0 5.8 2 2 3 5 5 5 0 Autophagy protein 16 (ATG16) AAA_27 PF13514.6 AFZ78997.1 - 0.44 10.1 0.0 0.44 10.1 0.0 4.2 4 1 0 4 4 4 0 AAA domain RNA_pol_Rpc4 PF05132.14 AFZ78998.1 - 7.1e-17 62.2 0.2 1.7e-15 57.8 0.0 2.1 1 1 1 2 2 2 2 RNA polymerase III RPC4 YqbF PF14553.6 AFZ78998.1 - 0.2 11.5 0.9 0.49 10.3 0.1 2.1 2 0 0 2 2 2 0 YqbF, hypothetical protein domain Kelch_5 PF13854.6 AFZ78999.1 - 3e-21 75.0 0.3 0.00039 20.3 0.0 6.8 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.6 AFZ78999.1 - 1.3e-19 70.0 1.4 7.5e-06 26.1 0.0 5.7 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_4 PF13418.6 AFZ78999.1 - 2e-19 69.3 10.3 1.4e-05 25.0 0.0 6.4 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.6 AFZ78999.1 - 2.7e-12 46.5 4.7 0.02 15.2 0.0 5.0 3 1 1 4 4 4 3 Kelch motif Kelch_1 PF01344.25 AFZ78999.1 - 3e-11 42.7 3.7 0.00013 21.5 0.0 4.8 5 0 0 5 5 5 2 Kelch motif HATPase_c_3 PF13589.6 AFZ78999.1 - 1.6e-10 40.9 0.0 3.3e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Kelch_2 PF07646.15 AFZ78999.1 - 1.6e-08 34.2 2.2 7.1e-05 22.6 0.0 4.1 4 0 0 4 4 4 2 Kelch motif HATPase_c PF02518.26 AFZ78999.1 - 3.1e-06 27.7 0.0 7.2e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase zf-CCCH PF00642.24 AFZ79000.1 - 0.0086 16.0 7.1 0.042 13.8 2.9 3.8 3 1 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 AFZ79000.1 - 0.043 13.9 0.5 0.043 13.9 0.5 5.0 4 1 0 4 4 4 0 Zinc finger domain Fer4_20 PF14691.6 AFZ79000.1 - 0.31 10.8 4.2 0.62 9.8 4.2 1.6 1 0 0 1 1 1 0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster zf-CCCH_4 PF18044.1 AFZ79000.1 - 0.56 10.1 17.9 0.54 10.1 0.2 3.9 4 0 0 4 4 4 0 CCCH-type zinc finger zf-CCCH_3 PF15663.5 AFZ79000.1 - 1.2 9.4 10.4 0.38 11.0 1.8 2.4 2 1 0 2 2 2 0 Zinc-finger containing family DER1 PF04511.15 AFZ79001.1 - 1.5e-41 142.4 14.7 1.7e-41 142.3 14.7 1.0 1 0 0 1 1 1 1 Der1-like family Plasmod_Pvs28 PF06247.11 AFZ79002.1 - 0.022 15.1 7.4 0.031 14.6 5.8 2.2 2 0 0 2 2 2 0 Pvs28 EGF domain EGF_MSP1_1 PF12946.7 AFZ79002.1 - 0.03 14.4 5.1 0.091 12.8 5.1 1.9 1 0 0 1 1 1 0 MSP1 EGF domain 1 hEGF PF12661.7 AFZ79002.1 - 1.8 9.3 8.3 1.2 9.9 4.9 2.7 2 0 0 2 2 2 0 Human growth factor-like EGF EB PF01683.18 AFZ79002.1 - 6.8 7.1 12.6 0.79 10.1 5.8 2.4 2 0 0 2 2 2 0 EB module DEAD PF00270.29 AFZ79003.1 - 6.1e-42 143.4 0.3 6.1e-42 143.4 0.3 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AFZ79003.1 - 4.6e-32 110.7 0.5 2.5e-31 108.3 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AFZ79003.1 - 1.8e-05 24.8 0.0 3.8e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 AFZ79003.1 - 0.00046 20.1 0.0 0.00094 19.1 0.0 1.4 1 0 0 1 1 1 1 Helicase AAA_30 PF13604.6 AFZ79003.1 - 0.00051 19.8 0.0 0.00086 19.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AFZ79003.1 - 0.00071 19.9 0.1 0.0055 17.0 0.1 2.1 2 0 0 2 2 2 1 AAA domain tRNA-synt_1b PF00579.25 AFZ79003.1 - 0.013 14.9 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) CMS1 PF14617.6 AFZ79003.1 - 0.034 13.5 0.2 0.084 12.2 0.0 1.7 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit fragilysinNterm PF16376.5 AFZ79003.1 - 0.071 12.9 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain of fragilysin DUF1198 PF06711.11 AFZ79003.1 - 0.11 12.5 0.2 0.37 10.8 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1198) tRNA_bind PF01588.20 AFZ79004.1 - 1.5e-27 95.5 0.0 2.4e-27 94.9 0.0 1.4 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C PF00043.25 AFZ79004.1 - 4.6e-07 30.0 0.0 1.1e-06 28.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 AFZ79004.1 - 5.4e-05 23.3 0.0 0.00019 21.5 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain His_Phos_1 PF00300.22 AFZ79005.1 - 1.1e-06 28.5 0.0 0.38 10.4 0.0 3.6 3 1 0 3 3 3 3 Histidine phosphatase superfamily (branch 1) Cnd1 PF12717.7 AFZ79006.1 - 0.067 13.2 0.3 0.067 13.2 0.3 3.5 3 2 1 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Receptor_IA-2 PF11548.8 AFZ79006.1 - 0.089 12.8 0.2 3.9 7.5 0.1 2.4 2 0 0 2 2 2 0 Protein-tyrosine phosphatase receptor IA-2 DUF4655 PF15548.6 AFZ79007.1 - 0.43 9.5 1.2 0.52 9.2 1.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4655) Asp_protease PF09668.10 AFZ79009.1 - 3.2e-40 136.8 0.4 5.5e-40 136.0 0.4 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 AFZ79009.1 - 1.3e-18 67.3 0.1 2.7e-18 66.3 0.1 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 AFZ79009.1 - 1.2e-12 48.3 0.1 2.2e-12 47.4 0.1 1.5 1 0 0 1 1 1 1 Aspartyl protease ubiquitin PF00240.23 AFZ79009.1 - 2.7e-05 23.8 0.2 2.7e-05 23.8 0.2 2.0 2 0 0 2 2 2 1 Ubiquitin family RVP PF00077.20 AFZ79009.1 - 4.7e-05 23.6 0.2 0.00026 21.3 0.2 2.2 1 1 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.11 AFZ79009.1 - 0.00013 21.8 0.1 0.00072 19.3 0.1 2.1 1 1 0 1 1 1 1 Retroviral aspartyl protease Peptidase_A2B PF12384.8 AFZ79009.1 - 0.0089 15.6 0.0 0.017 14.6 0.0 1.4 1 0 0 1 1 1 1 Ty3 transposon peptidase UBA_4 PF14555.6 AFZ79009.1 - 0.016 15.0 0.0 0.04 13.8 0.0 1.7 1 0 0 1 1 1 0 UBA-like domain AftA_N PF12250.8 AFZ79009.1 - 0.033 13.0 0.0 0.055 12.2 0.0 1.3 1 0 0 1 1 1 0 Arabinofuranosyltransferase N terminal TBK1_ULD PF18396.1 AFZ79009.1 - 0.062 13.2 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain DUF676 PF05057.14 AFZ79010.1 - 5e-21 75.2 0.1 7.9e-21 74.6 0.1 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 AFZ79010.1 - 2.4e-07 30.7 0.1 2.7e-07 30.6 0.1 1.3 1 1 0 1 1 1 1 PGAP1-like protein Palm_thioest PF02089.15 AFZ79010.1 - 2.5e-07 30.8 0.0 3.5e-07 30.3 0.0 1.4 1 1 0 1 1 1 1 Palmitoyl protein thioesterase LCAT PF02450.15 AFZ79010.1 - 1.2e-05 24.6 0.1 1.7e-05 24.2 0.1 1.3 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.8 AFZ79010.1 - 0.00019 20.8 0.0 0.00024 20.4 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 AFZ79010.1 - 0.00074 19.2 0.0 0.0011 18.6 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF900 PF05990.12 AFZ79010.1 - 0.0085 15.6 0.0 0.01 15.3 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Lipase_3 PF01764.25 AFZ79010.1 - 0.054 13.4 0.0 0.13 12.2 0.0 1.6 2 0 0 2 2 2 0 Lipase (class 3) Abhydrolase_6 PF12697.7 AFZ79010.1 - 0.066 13.8 0.0 0.078 13.6 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF3657 PF12394.8 AFZ79011.1 - 0.02 15.4 0.0 0.071 13.7 0.0 2.0 1 0 0 1 1 1 0 Protein FAM135 Cytochrome_cB PF11783.8 AFZ79011.1 - 0.065 13.1 0.2 0.15 12.0 0.2 1.5 1 0 0 1 1 1 0 Cytochrome c bacterial RAP PF08373.10 AFZ79013.1 - 1.2e-14 54.1 0.7 4.4e-14 52.3 0.3 2.3 2 0 0 2 2 2 1 RAP domain MTES_1575 PF18741.1 AFZ79013.1 - 1.9e-08 34.3 0.0 5.6e-08 32.9 0.0 1.8 1 0 0 1 1 1 1 REase_MTES_1575 FAST_1 PF06743.15 AFZ79013.1 - 2.7e-05 24.0 7.3 0.095 12.7 0.2 5.6 5 1 0 5 5 5 2 FAST kinase-like protein, subdomain 1 Mic1 PF07035.12 AFZ79014.1 - 1.7e-09 37.6 5.9 1.7e-09 37.6 5.9 1.9 2 0 0 2 2 2 1 Colon cancer-associated protein Mic1-like PK PF00224.21 AFZ79017.1 - 1.7e-86 290.2 0.2 3.1e-47 161.2 0.0 2.3 2 0 0 2 2 2 2 Pyruvate kinase, barrel domain PK_C PF02887.16 AFZ79017.1 - 0.0016 18.7 0.0 0.0033 17.7 0.0 1.5 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain IMPDH PF00478.25 AFZ79017.1 - 0.096 11.7 0.0 0.69 8.9 0.0 2.0 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain S4 PF01479.25 AFZ79019.1 - 0.00066 19.3 0.0 0.0012 18.5 0.0 1.4 1 0 0 1 1 1 1 S4 domain PseudoU_synth_2 PF00849.22 AFZ79019.1 - 0.0026 17.9 0.0 0.0039 17.3 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase potato_inhibit PF00280.18 AFZ79019.1 - 0.11 13.2 0.0 0.27 12.0 0.0 1.6 1 0 0 1 1 1 0 Potato inhibitor I family DUF3091 PF11291.8 AFZ79020.1 - 0.0072 16.5 0.1 0.013 15.6 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3091) Pkinase PF00069.25 AFZ79022.1 - 2e-62 211.0 0.1 4e-62 210.0 0.1 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ79022.1 - 8.8e-35 120.2 0.1 1.6e-34 119.4 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AFZ79022.1 - 8.8e-05 22.0 0.1 0.00034 20.0 0.0 1.9 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 AFZ79022.1 - 0.01 15.8 0.0 2.9 7.8 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family DDE_Tnp_IS240 PF13610.6 AFZ79022.1 - 0.038 14.2 2.3 2.3 8.5 0.1 2.6 2 0 0 2 2 2 0 DDE domain zf-ribbon_3 PF13248.6 AFZ79022.1 - 5.5 6.5 6.4 0.38 10.2 1.1 1.9 2 0 0 2 2 2 0 zinc-ribbon domain Peptidase_C1 PF00112.23 AFZ79023.1 - 5.6e-37 127.9 0.1 2.3e-36 125.9 0.0 2.0 2 1 0 2 2 2 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 AFZ79023.1 - 4.7e-09 36.5 10.0 1e-08 35.5 10.0 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 AFZ79023.1 - 0.014 14.2 1.1 0.028 13.2 0.0 1.9 2 1 0 2 2 2 0 Peptidase C1-like family DNA_pol3_beta PF00712.19 AFZ79023.1 - 0.13 12.4 0.1 0.27 11.3 0.1 1.6 1 0 0 1 1 1 0 DNA polymerase III beta subunit, N-terminal domain Mito_carr PF00153.27 AFZ79024.1 - 3.8e-66 219.1 5.1 4e-23 81.1 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein ubiquitin PF00240.23 AFZ79025.1 - 7e-25 86.6 1.5 1.4e-24 85.6 1.5 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 AFZ79025.1 - 1.8e-12 46.9 1.6 3.3e-12 46.1 1.6 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 AFZ79025.1 - 0.0002 21.4 0.3 0.00056 20.0 0.3 1.8 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 AFZ79025.1 - 0.00027 20.9 2.9 0.32 11.1 0.1 2.5 1 1 1 2 2 2 2 Ubiquitin-like domain Ubiquitin_5 PF18037.1 AFZ79025.1 - 0.00061 20.1 4.1 0.0011 19.2 2.4 2.0 1 1 1 2 2 2 1 Ubiquitin-like domain DUF2407 PF10302.9 AFZ79025.1 - 0.0024 18.4 1.5 0.0029 18.1 0.3 1.7 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain Ubiquitin_2 PF14560.6 AFZ79025.1 - 0.019 15.4 0.9 0.071 13.6 0.9 2.0 1 1 0 1 1 1 0 Ubiquitin-like domain TBK1_ULD PF18396.1 AFZ79025.1 - 0.027 14.4 0.3 0.049 13.5 0.3 1.4 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain TUG-UBL1 PF11470.8 AFZ79025.1 - 0.039 14.2 0.2 0.072 13.3 0.2 1.4 1 0 0 1 1 1 0 TUG ubiquitin-like domain ThiS PF02597.20 AFZ79025.1 - 0.076 13.7 0.2 0.12 13.0 0.2 1.4 1 0 0 1 1 1 0 ThiS family Dynamin_M PF01031.20 AFZ79026.1 - 1e-88 297.3 0.1 1e-88 297.3 0.1 1.7 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 AFZ79026.1 - 1.7e-49 168.1 0.1 4.8e-49 166.6 0.1 1.9 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 AFZ79026.1 - 3.4e-30 104.0 3.8 1.5e-29 101.9 3.8 2.2 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 AFZ79026.1 - 9.9e-06 25.6 0.2 0.0001 22.4 0.1 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_21 PF13304.6 AFZ79026.1 - 0.028 14.2 0.0 0.052 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Elf4 PF07011.11 AFZ79026.1 - 0.048 13.6 0.2 0.21 11.5 0.2 2.1 1 0 0 1 1 1 0 Early Flowering 4 domain Condensin2nSMC PF12422.8 AFZ79026.1 - 0.053 13.7 2.9 0.33 11.1 0.5 2.8 3 0 0 3 3 3 0 Condensin II non structural maintenance of chromosomes subunit ERCC3_RAD25_C PF16203.5 AFZ79027.1 - 2.5e-109 364.3 1.6 4e-109 363.6 1.6 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 AFZ79027.1 - 2.3e-28 98.9 0.0 5.2e-28 97.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AFZ79027.1 - 1.9e-16 60.5 0.0 5e-16 59.2 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 AFZ79027.1 - 1.3e-11 44.8 0.2 2.2e-10 40.8 0.1 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF2556 PF10831.8 AFZ79027.1 - 0.1 12.5 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2556) AAA_34 PF13872.6 AFZ79027.1 - 0.15 10.9 0.0 0.24 10.3 0.0 1.2 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 CobA_CobO_BtuR PF02572.15 AFZ79027.1 - 0.15 12.3 0.0 0.31 11.3 0.0 1.5 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Radical_SAM_C PF16199.5 AFZ79029.1 - 1.3e-19 69.9 0.2 3e-19 68.8 0.2 1.6 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 AFZ79029.1 - 1.8e-13 51.2 1.1 6.7e-13 49.3 1.1 2.0 1 1 0 1 1 1 1 Radical SAM superfamily GFA PF04828.14 AFZ79029.1 - 0.017 15.4 0.1 0.049 14.0 0.1 1.8 1 0 0 1 1 1 0 Glutathione-dependent formaldehyde-activating enzyme Acetyltransf_1 PF00583.25 AFZ79029.1 - 0.019 15.2 0.1 0.045 14.0 0.1 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family HSP70 PF00012.20 AFZ79031.1 - 6.4e-255 847.0 7.7 7.2e-255 846.8 7.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AFZ79031.1 - 7.6e-16 57.8 0.2 2.3e-14 53.0 0.1 2.2 2 0 0 2 2 2 1 MreB/Mbl protein DDR PF08841.10 AFZ79031.1 - 0.00036 19.6 0.3 0.028 13.4 0.2 2.3 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain FtsA PF14450.6 AFZ79031.1 - 0.00071 20.0 3.5 0.65 10.5 0.1 3.8 3 2 0 3 3 3 1 Cell division protein FtsA FGGY_C PF02782.16 AFZ79031.1 - 0.013 15.2 0.0 0.057 13.1 0.0 2.1 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain APP_N PF02177.16 AFZ79031.1 - 0.019 15.3 0.7 0.048 14.0 0.7 1.7 1 0 0 1 1 1 0 Amyloid A4 N-terminal heparin-binding Hydantoinase_A PF01968.18 AFZ79031.1 - 0.058 12.7 1.0 0.44 9.7 0.3 2.5 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase Mago_nashi PF02792.14 AFZ79031.1 - 1.4 9.0 4.5 0.96 9.6 0.1 2.3 2 1 0 2 2 2 0 Mago nashi protein zf-C3HC4_2 PF13923.6 AFZ79032.1 - 3.5e-08 33.2 17.9 1.2e-07 31.5 17.9 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AFZ79032.1 - 1.5e-07 31.2 20.1 5.7e-07 29.3 20.1 2.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AFZ79032.1 - 5.2e-07 29.4 17.4 1.4e-06 28.0 17.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AFZ79032.1 - 9.8e-07 28.6 20.0 2.8e-06 27.2 20.0 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 AFZ79032.1 - 1.7e-06 28.2 18.3 5.7e-06 26.6 18.3 2.0 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 AFZ79032.1 - 0.0001 22.1 16.4 0.00031 20.6 16.4 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 AFZ79032.1 - 0.00012 22.0 19.2 0.0003 20.7 17.4 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 AFZ79032.1 - 0.0021 18.2 15.8 0.0063 16.7 15.8 1.9 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-UDP PF14569.6 AFZ79032.1 - 0.068 13.3 7.1 0.19 11.9 7.1 1.8 1 0 0 1 1 1 0 Zinc-binding RING-finger TSC22 PF01166.18 AFZ79032.1 - 0.16 12.3 14.2 2.8 8.3 2.0 5.1 4 0 0 4 4 4 0 TSC-22/dip/bun family zf-RING_4 PF14570.6 AFZ79032.1 - 0.17 11.7 15.1 0.49 10.2 15.1 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF3987 PF13148.6 AFZ79032.1 - 0.25 10.3 1.3 0.46 9.4 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) zf-RING_6 PF14835.6 AFZ79032.1 - 0.33 10.8 8.1 0.89 9.5 8.1 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 AFZ79032.1 - 0.63 10.4 15.8 19 5.6 15.8 3.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain DUF4407 PF14362.6 AFZ79032.1 - 1.2 8.4 14.7 0.5 9.7 2.4 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) ApoO PF09769.9 AFZ79032.1 - 2.1 8.3 4.6 15 5.6 0.1 3.0 2 1 1 3 3 3 0 Apolipoprotein O Lactamase_B_6 PF16661.5 AFZ79033.1 - 5e-20 71.8 0.1 1.3e-19 70.4 0.1 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Beta-Casp PF10996.8 AFZ79033.1 - 0.00021 21.6 1.3 0.00068 19.9 0.1 2.5 3 0 0 3 3 3 1 Beta-Casp domain Lactamase_B_2 PF12706.7 AFZ79033.1 - 0.0078 15.7 0.1 0.014 14.9 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain IL13 PF03487.13 AFZ79033.1 - 0.19 11.5 0.6 1.2 9.0 0.2 2.5 1 1 1 2 2 2 0 Interleukin-13 AAA_23 PF13476.6 AFZ79035.1 - 1.9e-25 90.6 10.2 1.9e-25 90.6 10.2 7.0 3 2 3 7 7 6 1 AAA domain SMC_N PF02463.19 AFZ79035.1 - 1.8e-13 50.5 8.5 1.4e-08 34.5 4.3 3.6 4 1 0 4 4 3 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 AFZ79035.1 - 6e-07 29.5 25.1 6e-07 29.5 25.1 4.7 1 1 1 2 2 1 1 AAA ATPase domain AAA_21 PF13304.6 AFZ79035.1 - 3.3e-05 23.8 2.6 0.0014 18.5 0.1 4.2 5 0 0 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_13 PF13166.6 AFZ79035.1 - 0.00014 20.7 19.6 0.00014 20.7 19.6 5.7 3 2 3 6 6 6 3 AAA domain SbcCD_C PF13558.6 AFZ79035.1 - 0.00029 21.0 0.0 0.0011 19.2 0.0 2.0 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 AFZ79035.1 - 0.00051 19.7 0.0 0.0013 18.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 AFZ79035.1 - 0.0028 18.2 0.0 0.0028 18.2 0.0 5.6 3 2 0 3 3 1 1 ABC transporter AAA_16 PF13191.6 AFZ79035.1 - 0.011 16.2 0.0 0.047 14.1 0.0 2.1 1 0 0 1 1 1 0 AAA ATPase domain PuR_N PF09182.10 AFZ79035.1 - 0.04 13.9 0.0 0.13 12.2 0.0 1.9 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal AAA_33 PF13671.6 AFZ79035.1 - 0.076 13.2 0.0 0.4 10.8 0.0 2.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 AFZ79035.1 - 0.38 11.0 0.0 0.38 11.0 0.0 3.7 4 2 0 4 4 4 0 AAA domain AAA_19 PF13245.6 AFZ79035.1 - 1.9 8.8 11.8 8.4 6.7 0.0 3.7 2 1 0 2 2 2 0 AAA domain Fez1 PF06818.15 AFZ79035.1 - 4.2 7.8 67.1 0.28 11.6 14.5 5.3 2 2 2 4 4 4 0 Fez1 OEP PF02321.18 AFZ79035.1 - 6.9 6.4 11.4 1.1 9.0 5.7 2.7 2 0 0 2 2 2 0 Outer membrane efflux protein RRM_1 PF00076.22 AFZ79036.1 - 7.3e-25 86.6 0.0 4.5e-12 45.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AFZ79036.1 - 0.11 12.7 0.1 35 4.6 0.0 3.0 3 0 0 3 3 3 0 RNA recognition motif UQ_con PF00179.26 AFZ79037.1 - 3.3e-40 137.0 0.0 3.7e-40 136.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 AFZ79037.1 - 0.093 12.4 0.1 0.22 11.3 0.1 1.6 1 1 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 AFZ79037.1 - 0.14 12.4 0.4 0.21 11.9 0.4 1.5 1 1 0 1 1 1 0 RWD domain Coatomer_WDAD PF04053.14 AFZ79038.1 - 6e-78 262.9 9.4 9.5e-78 262.2 9.4 1.3 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 AFZ79038.1 - 1.9e-38 132.3 0.8 3.5e-38 131.4 0.8 1.5 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 AFZ79038.1 - 8.1e-33 111.9 21.4 1.7e-06 28.7 0.2 7.7 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AFZ79038.1 - 4e-07 30.2 1.9 0.036 14.4 0.0 4.4 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Clathrin PF00637.20 AFZ79038.1 - 0.031 14.2 0.2 0.34 10.8 0.0 2.7 2 1 0 2 2 2 0 Region in Clathrin and VPS ENTH PF01417.20 AFZ79038.1 - 0.06 13.4 0.5 14 5.8 0.2 2.8 2 0 0 2 2 2 0 ENTH domain Nup160 PF11715.8 AFZ79038.1 - 0.62 8.6 14.1 0.77 8.3 1.2 4.0 4 2 2 6 6 6 0 Nucleoporin Nup120/160 AP2 PF00847.20 AFZ79039.1 - 8.3e-09 35.6 4.9 1.2e-05 25.4 1.0 2.9 2 0 0 2 2 2 2 AP2 domain DUF2856 PF11043.8 AFZ79040.1 - 0.094 12.8 0.0 1.4 9.1 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2856) XRN_N PF03159.18 AFZ79041.1 - 6.4e-85 284.4 0.0 1.1e-84 283.6 0.0 1.4 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 AFZ79041.1 - 5.9e-45 154.0 12.2 6.5e-17 61.6 0.3 4.0 2 1 2 4 4 4 3 Xrn1 helical domain SH3_12 PF18129.1 AFZ79041.1 - 2e-24 85.5 0.1 1.7e-23 82.4 0.1 2.4 2 0 0 2 2 2 1 Xrn1 SH3-like domain XRN1_D1 PF18332.1 AFZ79041.1 - 6e-07 29.4 0.2 2.6e-06 27.3 0.1 2.0 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D1 domain MACPF PF01823.19 AFZ79042.1 - 9.6e-41 140.2 6.1 9.6e-41 140.2 6.1 3.5 2 1 0 2 2 2 1 MAC/Perforin domain tRNA-synt_2d PF01409.20 AFZ79043.1 - 6.1e-36 124.1 0.6 1.7e-20 73.5 0.0 3.3 2 1 1 3 3 3 3 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 AFZ79043.1 - 3.6e-16 59.4 0.0 6.6e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain tRNA-synt_2 PF00152.20 AFZ79043.1 - 0.037 13.1 0.0 1.3 8.1 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetases class II (D, K and N) C2 PF00168.30 AFZ79044.1 - 7.8e-10 39.0 0.3 2.6e-08 34.1 0.0 3.4 3 1 0 3 3 3 1 C2 domain IML1 PF12257.8 AFZ79044.1 - 0.0015 17.8 0.5 0.094 11.8 0.0 2.4 2 0 0 2 2 2 2 Vacuolar membrane-associated protein Iml1 DHO_dh PF01180.21 AFZ79045.1 - 2.9e-93 312.3 0.8 3.3e-93 312.1 0.8 1.0 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase NMO PF03060.15 AFZ79045.1 - 5.9e-05 22.6 0.0 7.7e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 AFZ79045.1 - 0.047 13.2 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 Histidine biosynthesis protein NanE PF04131.14 AFZ79045.1 - 0.053 12.7 0.0 0.17 11.0 0.0 1.8 2 0 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase TMP-TENI PF02581.17 AFZ79045.1 - 0.11 11.8 0.2 3 7.1 0.0 2.8 3 0 0 3 3 3 0 Thiamine monophosphate synthase ThiG PF05690.14 AFZ79045.1 - 0.13 11.5 0.2 0.51 9.6 0.0 1.9 1 1 1 2 2 2 0 Thiazole biosynthesis protein ThiG AAA PF00004.29 AFZ79046.1 - 1.7e-52 177.3 0.0 4.1e-39 134.0 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.18 AFZ79046.1 - 1.8e-11 44.1 0.0 3.9e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_5 PF07728.14 AFZ79046.1 - 7.9e-10 38.9 0.0 2e-05 24.6 0.0 2.9 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 AFZ79046.1 - 1.2e-09 37.8 0.0 2.4e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 AFZ79046.1 - 1.9e-09 38.1 0.7 0.0044 17.4 0.1 3.0 2 2 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 AFZ79046.1 - 4.1e-09 36.8 3.5 0.018 15.3 0.9 4.4 2 2 1 3 3 3 3 AAA domain AAA_33 PF13671.6 AFZ79046.1 - 3e-08 33.9 0.0 0.0049 17.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 AFZ79046.1 - 8.3e-08 31.8 0.0 0.0026 17.0 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_2 PF07724.14 AFZ79046.1 - 6.5e-07 29.6 0.0 7.4e-06 26.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 AFZ79046.1 - 1.7e-06 28.6 0.0 0.0069 16.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 AFZ79046.1 - 3.1e-06 27.2 0.0 0.11 12.5 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 AFZ79046.1 - 9.4e-06 25.6 0.1 0.11 12.4 0.0 3.0 2 1 0 2 2 2 2 NACHT domain AAA_14 PF13173.6 AFZ79046.1 - 1e-05 25.6 0.0 0.082 12.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 AFZ79046.1 - 1.1e-05 25.0 0.0 0.0056 16.1 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 AFZ79046.1 - 1.1e-05 25.5 0.1 0.46 10.4 0.0 4.1 2 2 2 4 4 4 1 ATPase domain predominantly from Archaea RuvB_N PF05496.12 AFZ79046.1 - 3e-05 23.8 0.1 0.014 15.1 0.0 2.7 3 0 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 AFZ79046.1 - 5.9e-05 22.8 0.0 0.39 10.4 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain RNA_helicase PF00910.22 AFZ79046.1 - 0.00017 22.0 0.0 0.044 14.2 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_7 PF12775.7 AFZ79046.1 - 0.0002 20.9 0.1 0.021 14.3 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region NB-ARC PF00931.22 AFZ79046.1 - 0.00051 19.3 0.1 1.1 8.4 0.0 2.5 2 0 0 2 2 2 2 NB-ARC domain AAA_24 PF13479.6 AFZ79046.1 - 0.00052 19.8 0.0 0.022 14.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 AFZ79046.1 - 0.0027 18.0 0.0 0.63 10.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 AFZ79046.1 - 0.0066 15.9 0.0 2.3 7.6 0.0 3.3 2 1 1 3 3 3 1 Bacterial TniB protein ATPase PF06745.13 AFZ79046.1 - 0.0072 15.7 0.1 0.072 12.4 0.0 2.3 2 0 0 2 2 2 1 KaiC AAA_25 PF13481.6 AFZ79046.1 - 0.014 15.0 2.7 0.78 9.3 0.0 2.9 3 1 1 4 4 3 0 AAA domain Zeta_toxin PF06414.12 AFZ79046.1 - 0.015 14.6 0.1 0.83 8.9 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin Parvo_NS1 PF01057.17 AFZ79046.1 - 0.016 14.3 0.0 0.11 11.5 0.0 2.0 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 ABC_tran PF00005.27 AFZ79046.1 - 0.018 15.6 0.2 1.4 9.4 0.0 2.6 2 0 0 2 2 2 0 ABC transporter AFG1_ATPase PF03969.16 AFZ79046.1 - 0.019 13.9 0.0 5.1 5.9 0.0 2.2 2 0 0 2 2 2 0 AFG1-like ATPase DUF2075 PF09848.9 AFZ79046.1 - 0.019 14.2 0.0 0.35 10.1 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DAP3 PF10236.9 AFZ79046.1 - 0.02 14.0 0.1 0.73 8.9 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 DNA_pol3_delta2 PF13177.6 AFZ79046.1 - 0.021 14.6 0.1 0.36 10.6 0.0 2.6 2 2 1 3 3 3 0 DNA polymerase III, delta subunit IstB_IS21 PF01695.17 AFZ79046.1 - 0.021 14.5 0.0 0.6 9.8 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_30 PF13604.6 AFZ79046.1 - 0.022 14.5 0.0 0.66 9.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 AFZ79046.1 - 0.024 14.4 0.3 2.8 7.8 0.0 2.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain ResIII PF04851.15 AFZ79046.1 - 0.027 14.5 0.0 2.2 8.2 0.0 2.6 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit Rad17 PF03215.15 AFZ79046.1 - 0.03 14.2 0.1 0.12 12.3 0.0 2.0 2 1 1 3 3 1 0 Rad17 P-loop domain AAA_17 PF13207.6 AFZ79046.1 - 0.044 14.2 0.5 11 6.5 0.0 3.1 2 1 0 3 3 3 0 AAA domain Torsin PF06309.11 AFZ79046.1 - 0.079 13.1 0.0 14 5.8 0.0 2.5 2 0 0 2 2 2 0 Torsin AAA_19 PF13245.6 AFZ79046.1 - 0.098 13.0 0.0 0.68 10.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 AFZ79046.1 - 0.12 11.6 0.1 2.1 7.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) CPT PF07931.12 AFZ79046.1 - 0.12 12.2 0.2 0.92 9.3 0.0 2.3 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein PhoH PF02562.16 AFZ79046.1 - 0.12 11.8 0.0 2.1 7.8 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein AAA_3 PF07726.11 AFZ79046.1 - 0.14 12.1 0.0 0.81 9.6 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Sterile PF03015.19 AFZ79047.1 - 0.0082 16.3 0.1 0.16 12.2 0.0 2.6 2 0 0 2 2 2 1 Male sterility protein CRM1_C PF08767.11 AFZ79048.1 - 1.6e-96 323.3 4.3 1.6e-96 323.3 4.3 3.0 4 0 0 4 4 4 1 CRM1 C terminal Xpo1 PF08389.12 AFZ79048.1 - 1.8e-32 112.4 2.7 1.8e-32 112.4 2.7 4.8 5 0 0 5 5 5 1 Exportin 1-like protein CRM1_repeat_3 PF18787.1 AFZ79048.1 - 3.6e-13 49.4 0.7 3.6e-13 49.4 0.7 3.3 3 0 0 3 3 3 1 CRM1 / Exportin repeat 3 IBN_N PF03810.19 AFZ79048.1 - 4e-13 49.1 0.3 1.9e-12 46.9 0.3 2.3 1 0 0 1 1 1 1 Importin-beta N-terminal domain CRM1_repeat_2 PF18784.1 AFZ79048.1 - 4.5e-13 48.6 5.4 6.1e-13 48.2 2.7 2.7 2 0 0 2 2 2 1 CRM1 / Exportin repeat 2 CRM1_repeat PF18777.1 AFZ79048.1 - 7.1e-07 28.6 1.6 1.7e-06 27.4 0.6 2.4 2 0 0 2 2 2 1 Chromosome region maintenance or exportin repeat CsgA PF17334.2 AFZ79048.1 - 0.4 11.5 3.4 2 9.2 0.6 3.5 3 0 0 3 3 3 0 Minor curli fiber component A IL7 PF01415.16 AFZ79048.1 - 0.81 9.7 8.1 7.4 6.6 0.1 3.6 4 0 0 4 4 4 0 Interleukin 7/9 family Pkinase PF00069.25 AFZ79049.1 - 2.1e-48 165.0 0.1 8.8e-48 163.0 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ79049.1 - 5.2e-21 75.1 0.0 2.4e-20 72.9 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Urb2 PF10441.9 AFZ79049.1 - 0.0079 16.1 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 Urb2/Npa2 family Kdo PF06293.14 AFZ79049.1 - 0.048 13.0 0.0 0.13 11.6 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1748 PF08520.10 AFZ79049.1 - 0.06 13.2 0.0 0.2 11.6 0.0 1.9 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1748) TYW3 PF02676.14 AFZ79050.1 - 8.5e-38 129.9 0.1 1.7e-37 128.9 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase TYW3 Met_10 PF02475.16 AFZ79050.1 - 4.3e-18 65.8 0.1 1.1e-17 64.5 0.1 1.7 1 1 0 1 1 1 1 Met-10+ like-protein Kelch_4 PF13418.6 AFZ79050.1 - 5e-14 52.0 1.2 0.00075 19.4 0.0 4.5 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.6 AFZ79050.1 - 1.9e-06 27.7 7.9 0.66 10.0 0.0 5.9 6 0 0 6 6 6 2 Kelch motif RAG2 PF03089.14 AFZ79050.1 - 0.0016 17.5 0.3 0.0042 16.1 0.1 1.8 2 0 0 2 2 2 1 Recombination activating protein 2 Methyltransf_25 PF13649.6 AFZ79050.1 - 0.007 17.1 0.0 0.03 15.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AFZ79050.1 - 0.012 15.2 0.0 0.025 14.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain TRM PF02005.16 AFZ79050.1 - 0.082 12.1 0.0 0.17 11.0 0.0 1.5 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_18 PF12847.7 AFZ79050.1 - 0.14 12.1 0.8 0.87 9.5 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain PHF5 PF03660.14 AFZ79051.1 - 1e-49 167.1 15.6 1.2e-49 166.8 15.6 1.0 1 0 0 1 1 1 1 PHF5-like protein DZR PF12773.7 AFZ79051.1 - 1.3 9.2 18.4 0.071 13.1 9.3 2.7 1 1 1 2 2 2 0 Double zinc ribbon PolC_DP2 PF03833.13 AFZ79051.1 - 3.3 5.5 9.7 3.4 5.4 9.7 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 GTP_EFTU PF00009.27 AFZ79052.1 - 2.9e-32 111.8 0.0 2.9e-32 111.8 0.0 3.1 2 2 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 AFZ79052.1 - 5e-18 65.1 0.2 1.7e-17 63.5 0.2 1.9 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.6 AFZ79052.1 - 5.8e-14 51.7 0.0 1.8e-13 50.2 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 4 GTP_EFTU_D2 PF03144.25 AFZ79052.1 - 1e-12 48.3 5.5 1.6e-09 38.0 0.3 3.6 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AFZ79052.1 - 1.3e-05 25.2 7.0 1.7e-05 24.8 0.0 3.8 4 0 0 4 4 4 1 50S ribosome-binding GTPase Roc PF08477.13 AFZ79052.1 - 0.00023 21.4 0.3 0.00089 19.5 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 AFZ79052.1 - 0.031 14.1 0.0 0.031 14.1 0.0 2.7 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein zf-RING_2 PF13639.6 AFZ79053.1 - 6.3e-12 45.6 7.1 6.3e-12 45.6 7.1 2.6 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 AFZ79053.1 - 2.3e-07 30.4 4.1 2.3e-07 30.4 4.1 3.2 3 0 0 3 3 2 1 RING-like zinc finger zf-rbx1 PF12678.7 AFZ79053.1 - 6.8e-07 29.5 6.1 1.7e-06 28.2 6.1 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 AFZ79053.1 - 6.9e-07 29.1 3.6 6.9e-07 29.1 3.6 1.8 2 0 0 2 2 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 AFZ79053.1 - 8.9e-07 28.7 7.3 8.9e-07 28.7 7.3 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AFZ79053.1 - 1.5e-06 28.0 5.4 1.5e-06 28.0 5.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 AFZ79053.1 - 1.8e-05 24.3 3.9 5.5e-05 22.7 3.9 1.9 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4 PF00097.25 AFZ79053.1 - 3.8e-05 23.5 5.6 3.8e-05 23.5 5.6 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 AFZ79053.1 - 0.0005 19.9 7.8 0.0005 19.9 7.8 1.9 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 RINGv PF12906.7 AFZ79053.1 - 0.0011 19.1 6.0 0.0011 19.1 6.0 2.2 2 0 0 2 2 2 1 RING-variant domain zf-RING_UBOX PF13445.6 AFZ79053.1 - 0.0037 17.3 0.6 0.0037 17.3 0.6 2.4 2 1 1 3 3 3 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 AFZ79053.1 - 0.008 16.2 4.2 0.0097 15.9 2.6 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Baculo_RING PF05883.11 AFZ79053.1 - 0.067 13.2 3.1 0.12 12.3 3.1 1.4 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain FANCL_C PF11793.8 AFZ79053.1 - 0.1 12.8 9.8 0.09 13.0 6.1 2.7 2 1 0 2 2 2 0 FANCL C-terminal domain zf-RING_4 PF14570.6 AFZ79053.1 - 1 9.2 9.3 0.22 11.3 5.3 1.9 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.11 AFZ79053.1 - 1.2 9.5 5.8 3.6 8.0 5.8 2.0 1 1 0 1 1 1 0 RING-like domain DUF373 PF04123.13 AFZ79053.1 - 3.2 7.1 6.3 4.8 6.5 6.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF373) EXS PF03124.14 AFZ79054.1 - 3.2e-52 177.9 22.8 4.9e-52 177.3 22.8 1.3 1 0 0 1 1 1 1 EXS family SPX PF03105.19 AFZ79054.1 - 1.1e-11 45.4 9.1 1.2e-08 35.3 1.0 2.1 1 1 1 2 2 2 2 SPX domain AIP3 PF03915.13 AFZ79054.1 - 0.027 13.6 0.1 0.048 12.7 0.1 1.3 1 0 0 1 1 1 0 Actin interacting protein 3 WD40 PF00400.32 AFZ79055.1 - 8.5e-06 26.4 7.5 0.0068 17.2 0.0 4.3 5 0 0 5 5 5 2 WD domain, G-beta repeat UCH_N PF16674.5 AFZ79055.1 - 0.094 12.7 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 N-terminal of ubiquitin carboxyl-terminal hydrolase 37 GYF PF02213.16 AFZ79057.1 - 9.2e-13 47.6 4.5 2.1e-12 46.5 4.5 1.7 1 0 0 1 1 1 1 GYF domain ribosomal_L24 PF17136.4 AFZ79058.1 - 4.4e-11 43.0 0.1 1e-10 41.8 0.1 1.7 1 0 0 1 1 1 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.29 AFZ79058.1 - 0.0014 18.5 1.2 0.0037 17.2 1.2 1.8 1 0 0 1 1 1 1 KOW motif Cyclin_N PF00134.23 AFZ79060.1 - 1.8e-08 34.2 0.2 3.9e-08 33.1 0.2 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain RRM_occluded PF16842.5 AFZ79060.1 - 0.13 12.1 0.1 0.29 11.0 0.1 1.6 1 0 0 1 1 1 0 Occluded RNA-recognition motif Pkinase PF00069.25 AFZ79061.1 - 8.6e-58 195.8 0.0 1e-57 195.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ79061.1 - 6.8e-35 120.6 0.0 8.7e-35 120.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AFZ79061.1 - 2.1e-06 27.3 0.0 3.1e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 AFZ79061.1 - 0.0034 16.8 0.3 0.0054 16.1 0.3 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Glutaredoxin PF00462.24 AFZ79064.1 - 1.7e-16 60.2 0.0 4.9e-16 58.7 0.0 1.8 2 0 0 2 2 2 1 Glutaredoxin TnpW PF14202.6 AFZ79064.1 - 0.0021 17.9 0.1 0.0041 16.9 0.1 1.4 1 0 0 1 1 1 1 Transposon-encoded protein TnpW Thioredoxin_6 PF13848.6 AFZ79064.1 - 0.0047 16.9 0.1 0.054 13.4 0.0 2.1 1 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin PF00085.20 AFZ79064.1 - 0.011 15.7 0.0 0.022 14.7 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin GST_N_3 PF13417.6 AFZ79064.1 - 0.02 15.3 0.0 0.05 14.0 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Ligase_CoA PF00549.19 AFZ79064.1 - 0.12 12.2 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 CoA-ligase Methyltransf_23 PF13489.6 AFZ79065.1 - 7e-22 78.0 0.0 9.6e-22 77.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AFZ79065.1 - 1.7e-15 57.4 0.0 3.5e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AFZ79065.1 - 7.3e-15 55.5 0.0 3.3e-14 53.3 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 AFZ79065.1 - 7.3e-15 55.5 0.0 1.3e-14 54.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AFZ79065.1 - 1.5e-14 54.0 0.1 5e-14 52.4 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase domain CMAS PF02353.20 AFZ79065.1 - 9.3e-10 38.3 0.1 2.3e-09 37.0 0.1 1.5 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase NodS PF05401.11 AFZ79065.1 - 1.5e-06 28.0 0.0 5.9e-06 26.0 0.0 1.8 1 1 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_32 PF13679.6 AFZ79065.1 - 1.4e-05 25.1 0.0 2.1e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 AFZ79065.1 - 3.9e-05 22.8 0.1 5.8e-05 22.3 0.1 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase PrmA PF06325.13 AFZ79065.1 - 0.00013 21.5 0.0 0.00021 20.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 AFZ79065.1 - 0.0006 19.6 0.0 0.0016 18.2 0.0 1.6 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CheR PF01739.18 AFZ79065.1 - 0.0013 18.3 0.4 0.0036 16.8 0.4 1.8 1 1 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_PK PF05891.12 AFZ79065.1 - 0.0021 17.6 0.0 0.0034 16.9 0.0 1.3 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_15 PF09445.10 AFZ79065.1 - 0.0057 16.3 0.1 0.011 15.3 0.1 1.5 1 1 0 1 1 1 1 RNA cap guanine-N2 methyltransferase MetW PF07021.12 AFZ79065.1 - 0.011 15.3 0.1 0.027 14.1 0.1 1.6 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_9 PF08003.11 AFZ79065.1 - 0.013 14.4 0.1 0.022 13.7 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1698) MTS PF05175.14 AFZ79065.1 - 0.017 14.7 0.0 0.028 14.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain TehB PF03848.14 AFZ79065.1 - 0.028 13.9 0.1 0.057 12.8 0.1 1.5 1 1 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_4 PF02390.17 AFZ79065.1 - 0.035 13.6 0.0 0.15 11.5 0.0 1.9 2 0 0 2 2 2 0 Putative methyltransferase 3HCDH_N PF02737.18 AFZ79065.1 - 0.048 13.6 0.0 0.065 13.1 0.0 1.1 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 AFZ79065.1 - 0.086 12.4 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox PF00070.27 AFZ79065.1 - 0.16 12.5 0.1 26 5.5 0.0 2.3 1 1 1 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase PDCD2_C PF04194.13 AFZ79066.1 - 1.7e-11 44.5 0.1 2.4e-11 44.0 0.1 1.3 1 0 0 1 1 1 1 Programmed cell death protein 2, C-terminal putative domain Topoisom_I PF01028.20 AFZ79067.1 - 2e-102 341.4 7.3 2e-102 341.4 7.3 2.2 4 0 0 4 4 4 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 AFZ79067.1 - 4.9e-74 248.4 5.8 4.9e-74 248.4 5.8 2.7 3 1 1 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 AFZ79067.1 - 1.2e-31 108.4 1.4 1.2e-31 108.4 1.4 2.2 2 0 0 2 2 2 1 C-terminal topoisomerase domain DUF4269 PF14091.6 AFZ79067.1 - 0.021 15.1 0.0 0.056 13.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4269) FlaC_arch PF05377.11 AFZ79067.1 - 0.95 9.9 4.7 1.2 9.6 0.7 3.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) CREPT PF16566.5 AFZ79067.1 - 4.7 7.4 8.5 1.6 8.9 3.8 2.5 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Bromodomain PF00439.25 AFZ79068.1 - 4.8e-14 52.2 0.2 6.9e-13 48.5 0.1 2.4 2 0 0 2 2 2 1 Bromodomain DUF1281 PF06924.11 AFZ79068.1 - 0.062 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1281) PIP5K PF01504.18 AFZ79069.1 - 4.5e-75 252.4 1.1 3.9e-74 249.3 1.1 2.1 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase EF-hand_1 PF00036.32 AFZ79069.1 - 0.0014 18.0 3.7 0.0029 17.0 0.2 3.0 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 AFZ79069.1 - 0.0067 16.3 1.9 0.2 11.6 0.4 3.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.6 AFZ79069.1 - 0.021 14.3 0.3 0.048 13.2 0.3 1.6 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 AFZ79069.1 - 0.25 11.8 1.0 4 8.0 0.1 3.0 2 1 1 3 3 3 0 EF-hand domain pair EF-hand_8 PF13833.6 AFZ79069.1 - 0.51 10.2 3.5 0.41 10.5 0.5 2.4 3 0 0 3 3 3 0 EF-hand domain pair JAB PF01398.21 AFZ79070.1 - 1.4e-31 108.9 0.0 2.6e-31 108.1 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 AFZ79070.1 - 4.1e-09 36.2 0.0 8.3e-09 35.2 0.0 1.6 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain MitMem_reg PF13012.6 AFZ79070.1 - 4.2e-09 36.8 0.4 8.1e-09 35.9 0.4 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function TFIIB PF00382.19 AFZ79071.1 - 8.8e-12 44.9 0.8 1.4e-09 37.8 0.0 2.6 2 1 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 AFZ79071.1 - 1.2e-09 37.5 0.6 1.2e-09 37.5 0.6 2.2 2 0 0 2 2 2 1 TFIIB zinc-binding AAA_lid_7 PF17867.1 AFZ79071.1 - 0.054 13.7 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 Midasin AAA lid domain Zn-ribbon_8 PF09723.10 AFZ79071.1 - 0.22 11.7 1.4 0.73 10.0 0.1 2.4 2 0 0 2 2 2 0 Zinc ribbon domain AAA_18 PF13238.6 AFZ79072.1 - 9.1e-25 87.7 0.1 1.3e-24 87.2 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 AFZ79072.1 - 2.3e-09 37.8 0.2 1.3e-07 32.1 0.2 2.2 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 AFZ79072.1 - 4.4e-07 30.1 0.0 0.00045 20.4 0.0 2.2 2 0 0 2 2 2 2 AAA domain ADK PF00406.22 AFZ79072.1 - 1.1e-05 25.6 0.1 0.0012 19.0 0.0 2.1 2 0 0 2 2 2 1 Adenylate kinase AAA PF00004.29 AFZ79072.1 - 3.3e-05 24.3 0.9 7.5e-05 23.2 0.9 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 AFZ79072.1 - 0.00029 20.7 0.0 0.00067 19.5 0.0 1.6 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase ATP_bind_1 PF03029.17 AFZ79072.1 - 0.0003 20.6 1.6 0.08 12.7 0.0 2.1 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein AAA_5 PF07728.14 AFZ79072.1 - 0.00057 19.9 0.4 0.0018 18.3 0.0 1.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 AFZ79072.1 - 0.00059 20.3 1.1 0.0012 19.3 1.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AFZ79072.1 - 0.00078 19.7 3.2 0.0048 17.2 3.2 2.3 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 AFZ79072.1 - 0.00093 19.7 0.6 0.0022 18.5 0.6 1.6 1 1 0 1 1 1 1 ABC transporter AAA_28 PF13521.6 AFZ79072.1 - 0.0011 19.3 0.0 0.0079 16.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain DUF5387 PF17361.2 AFZ79072.1 - 0.0013 18.4 3.1 0.0027 17.4 3.1 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5387) dNK PF01712.19 AFZ79072.1 - 0.0016 18.4 2.3 0.19 11.6 0.3 2.4 1 1 0 2 2 2 1 Deoxynucleoside kinase DUF815 PF05673.13 AFZ79072.1 - 0.0016 17.7 0.0 0.0029 16.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) NTPase_1 PF03266.15 AFZ79072.1 - 0.0016 18.3 0.7 0.0039 17.1 0.1 1.8 2 0 0 2 2 2 1 NTPase NB-ARC PF00931.22 AFZ79072.1 - 0.003 16.8 2.8 0.02 14.1 2.8 2.1 1 1 0 1 1 1 1 NB-ARC domain AAA_7 PF12775.7 AFZ79072.1 - 0.0031 17.1 0.0 0.0071 15.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region MMR_HSR1 PF01926.23 AFZ79072.1 - 0.0042 17.1 0.8 0.0083 16.2 0.8 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_14 PF13173.6 AFZ79072.1 - 0.0059 16.6 2.0 0.057 13.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 AFZ79072.1 - 0.0064 15.9 1.2 0.043 13.2 0.0 2.1 2 0 0 2 2 2 1 FtsK/SpoIIIE family RNA_helicase PF00910.22 AFZ79072.1 - 0.01 16.2 0.1 0.036 14.4 0.0 1.9 2 0 0 2 2 2 0 RNA helicase DUF87 PF01935.17 AFZ79072.1 - 0.012 15.7 1.0 0.12 12.4 0.0 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain GTP_EFTU PF00009.27 AFZ79072.1 - 0.013 15.0 0.1 0.068 12.7 0.0 1.9 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain TniB PF05621.11 AFZ79072.1 - 0.015 14.7 0.0 0.026 13.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein SKI PF01202.22 AFZ79072.1 - 0.015 15.4 0.0 2.5 8.2 0.0 2.2 2 0 0 2 2 2 0 Shikimate kinase AAA_19 PF13245.6 AFZ79072.1 - 0.016 15.5 2.2 0.042 14.2 2.2 2.0 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 AFZ79072.1 - 0.017 14.8 1.4 0.03 14.1 1.4 1.8 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 AFZ79072.1 - 0.021 14.7 0.7 0.035 14.0 0.1 1.7 2 0 0 2 2 2 0 RsgA GTPase Thymidylate_kin PF02223.17 AFZ79072.1 - 0.022 14.5 1.6 3.3 7.3 0.0 2.1 2 0 0 2 2 2 0 Thymidylate kinase AAA_32 PF13654.6 AFZ79072.1 - 0.023 13.5 2.2 0.07 11.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 AFZ79072.1 - 0.029 13.7 0.3 0.091 12.1 0.0 1.9 2 1 0 2 2 2 0 KaiC AAA_29 PF13555.6 AFZ79072.1 - 0.032 14.0 0.0 0.073 12.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 AFZ79072.1 - 0.035 14.3 0.0 0.086 13.1 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase NACHT PF05729.12 AFZ79072.1 - 0.038 13.9 0.0 0.081 12.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Mg_chelatase PF01078.21 AFZ79072.1 - 0.042 13.2 0.0 0.077 12.4 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI MCM PF00493.23 AFZ79072.1 - 0.042 12.9 0.0 0.082 12.0 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain Sigma54_activat PF00158.26 AFZ79072.1 - 0.091 12.5 0.0 0.2 11.4 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain ATP-synt_ab PF00006.25 AFZ79072.1 - 0.18 11.5 0.0 0.18 11.5 0.0 1.3 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Methyltr_RsmB-F PF01189.17 AFZ79073.1 - 6.1e-30 104.4 0.0 1.5e-29 103.1 0.0 1.6 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.6 AFZ79073.1 - 4.2e-09 36.4 0.0 6.6e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AFZ79073.1 - 9.4e-07 28.4 0.0 1.9e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltr_RsmF_N PF17125.5 AFZ79073.1 - 5.2e-05 23.7 0.0 0.00015 22.2 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF Methyltransf_25 PF13649.6 AFZ79073.1 - 0.00062 20.4 0.0 0.002 18.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AFZ79073.1 - 0.0024 17.4 0.0 0.37 10.3 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_12 PF08242.12 AFZ79073.1 - 0.026 15.2 0.0 11 6.9 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain FtsJ PF01728.19 AFZ79073.1 - 0.078 13.1 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Citrate_bind PF16114.5 AFZ79073.1 - 0.12 11.9 0.0 0.71 9.4 0.0 1.9 2 0 0 2 2 2 0 ATP citrate lyase citrate-binding N6_Mtase PF02384.16 AFZ79073.1 - 0.12 11.6 0.1 0.38 10.0 0.1 1.8 1 1 0 1 1 1 0 N-6 DNA Methylase PCMT PF01135.19 AFZ79073.1 - 0.15 11.8 0.0 0.4 10.4 0.0 1.6 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF485 PF04341.12 AFZ79074.1 - 0.0013 18.7 2.5 0.027 14.4 0.8 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF485 RNA_POL_M_15KD PF02150.16 AFZ79075.1 - 2.1e-07 30.7 2.5 2.1e-07 30.7 2.5 2.5 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 AFZ79075.1 - 1.9e-05 24.4 1.1 1.9e-05 24.4 1.1 3.0 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) DZR PF12773.7 AFZ79075.1 - 0.059 13.4 3.1 0.2 11.7 1.7 2.3 2 0 0 2 2 2 0 Double zinc ribbon zf-B_box PF00643.24 AFZ79075.1 - 0.69 10.1 5.7 0.38 11.0 1.6 2.4 2 0 0 2 2 2 0 B-box zinc finger OrfB_Zn_ribbon PF07282.11 AFZ79075.1 - 2.4 8.2 9.2 0.32 11.0 1.3 2.6 3 0 0 3 3 3 0 Putative transposase DNA-binding domain zinc_ribbon_10 PF10058.9 AFZ79075.1 - 5.2 6.9 9.8 13 5.6 0.1 3.3 3 1 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein GFA PF04828.14 AFZ79075.1 - 9.4 6.7 10.5 1.2 9.5 0.3 3.1 2 2 1 3 3 3 0 Glutathione-dependent formaldehyde-activating enzyme Evr1_Alr PF04777.13 AFZ79076.1 - 1.7e-18 66.9 0.0 2.5e-18 66.4 0.0 1.2 1 0 0 1 1 1 1 Erv1 / Alr family MCPsignal PF00015.21 AFZ79078.1 - 0.014 15.3 3.8 1.1 9.1 0.2 2.2 1 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Spore_III_AB PF09548.10 AFZ79078.1 - 0.015 15.4 0.2 0.025 14.7 0.2 1.4 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) NPV_P10 PF05531.12 AFZ79078.1 - 0.079 13.4 4.9 0.54 10.8 2.6 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein TMF_DNA_bd PF12329.8 AFZ79078.1 - 0.087 12.8 0.5 0.087 12.8 0.5 2.6 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding SlyX PF04102.12 AFZ79078.1 - 0.24 12.0 2.1 33 5.2 0.0 2.9 3 0 0 3 3 3 0 SlyX DUF4795 PF16043.5 AFZ79078.1 - 0.99 9.0 6.1 3.3 7.3 0.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) Mod_r PF07200.13 AFZ79078.1 - 1.5 8.9 5.1 4.9 7.2 5.1 1.9 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Fib_alpha PF08702.10 AFZ79078.1 - 7.2 6.8 7.8 9.1 6.5 6.9 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family G10 PF01125.17 AFZ79079.1 - 1.3e-62 209.9 1.6 1.4e-62 209.8 1.6 1.0 1 0 0 1 1 1 1 G10 protein zf-CCCH PF00642.24 AFZ79080.1 - 8.6e-07 28.7 2.6 8.6e-07 28.7 2.6 4.6 5 1 0 5 5 5 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 AFZ79080.1 - 4.8e-06 26.4 4.7 4.8e-06 26.4 4.7 5.0 5 0 0 5 5 5 2 Zinc finger domain zf-CCCH_2 PF14608.6 AFZ79080.1 - 0.00025 21.4 10.7 0.024 15.1 1.1 3.5 3 0 0 3 3 3 3 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 AFZ79080.1 - 0.00032 20.4 2.1 0.00032 20.4 2.1 4.3 5 0 0 5 5 5 1 CCCH-type zinc finger zf-CCCH_3 PF15663.5 AFZ79080.1 - 0.0025 18.0 6.8 0.11 12.7 6.3 2.5 1 1 1 2 2 2 2 Zinc-finger containing family Torus PF16131.5 AFZ79080.1 - 0.0066 17.1 12.1 0.012 16.3 1.7 3.0 1 1 2 3 3 3 2 Torus domain Peptidase_M16_C PF05193.21 AFZ79081.1 - 9e-32 110.6 0.0 2.3e-30 105.9 0.0 2.2 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 AFZ79081.1 - 6.4e-27 94.4 0.1 1.4e-26 93.3 0.0 1.5 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) DnaJ-X PF14308.6 AFZ79084.1 - 1.6e-45 155.2 2.6 1.6e-45 155.2 2.6 1.7 3 0 0 3 3 3 1 X-domain of DnaJ-containing DnaJ PF00226.31 AFZ79084.1 - 1.7e-23 82.5 1.6 4.5e-23 81.1 1.1 2.0 2 0 0 2 2 2 1 DnaJ domain ATG_C PF09333.11 AFZ79084.1 - 2e-06 28.0 0.0 7.1e-06 26.3 0.0 2.0 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Ribosomal_S14 PF00253.21 AFZ79085.1 - 1.3e-14 53.7 2.4 1.4e-14 53.5 2.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e zf-met2 PF12907.7 AFZ79085.1 - 6.1 7.1 7.4 18 5.6 0.1 3.0 3 0 0 3 3 3 0 Zinc-binding CAP PF00188.26 AFZ79086.1 - 3e-17 63.6 0.2 4e-17 63.2 0.2 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family CRT-like PF08627.10 AFZ79087.1 - 1.2e-51 175.7 21.5 1.2e-51 175.7 21.5 1.4 2 0 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like IRK PF01007.20 AFZ79087.1 - 0.027 14.3 0.3 0.027 14.3 0.3 3.0 3 1 1 4 4 4 0 Inward rectifier potassium channel transmembrane domain DUF3938 PF13074.6 AFZ79087.1 - 7.9 6.8 12.7 1.2 9.5 0.3 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF3938) AlgF PF11182.8 AFZ79088.1 - 0.0027 17.5 0.0 0.0041 16.9 0.0 1.3 1 0 0 1 1 1 1 Alginate O-acetyl transferase AlgF AP2 PF00847.20 AFZ79089.1 - 4e-09 36.6 1.3 4e-09 36.6 1.3 2.3 2 1 1 3 3 3 1 AP2 domain WD40 PF00400.32 AFZ79090.1 - 5e-07 30.3 10.1 1.7e-05 25.4 0.2 4.5 5 0 0 5 5 5 2 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 AFZ79090.1 - 0.015 14.4 3.4 0.018 14.1 2.7 1.3 1 1 0 1 1 1 0 Coatomer WD associated region Syntaxin PF00804.25 AFZ79091.1 - 5.5e-20 71.9 2.6 7.5e-20 71.5 2.6 1.2 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.19 AFZ79091.1 - 6.7e-05 22.8 0.1 0.00027 20.8 0.1 2.2 1 0 0 1 1 1 1 SNARE domain Syntaxin_2 PF14523.6 AFZ79091.1 - 9.1e-05 22.8 3.7 9.1e-05 22.8 3.7 1.9 2 1 0 2 2 2 1 Syntaxin-like protein MCM_N PF14551.6 AFZ79091.1 - 0.02 15.5 1.8 0.069 13.7 0.1 2.3 2 1 0 2 2 2 0 MCM N-terminal domain GIT1_C PF12205.8 AFZ79091.1 - 0.066 13.3 4.2 0.094 12.8 1.1 2.3 1 1 1 2 2 2 0 G protein-coupled receptor kinase-interacting protein 1 C term NinE PF05322.11 AFZ79091.1 - 0.092 12.6 0.9 0.17 11.8 0.9 1.4 1 0 0 1 1 1 0 NINE Protein Tetrabrachion PF11401.8 AFZ79091.1 - 0.093 12.7 0.2 0.19 11.8 0.2 1.5 1 0 0 1 1 1 0 Tetrabrachion DASH_Hsk3 PF08227.11 AFZ79091.1 - 2 8.8 5.1 0.41 11.1 0.9 2.0 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like Josephin PF02099.17 AFZ79092.1 - 1.3e-20 74.2 0.1 1.7e-20 73.8 0.1 1.1 1 0 0 1 1 1 1 Josephin zf-CCHC_2 PF13696.6 AFZ79092.1 - 0.027 14.3 3.6 1.4 8.8 0.0 2.5 2 0 0 2 2 2 0 Zinc knuckle Peptidase_C39 PF03412.15 AFZ79092.1 - 0.058 13.2 0.1 0.57 10.0 0.1 2.2 2 0 0 2 2 2 0 Peptidase C39 family IBN_N PF03810.19 AFZ79093.1 - 1.9e-09 37.3 0.0 2.1e-08 34.0 0.0 2.8 2 0 0 2 2 2 1 Importin-beta N-terminal domain RSS_P20 PF11757.8 AFZ79093.1 - 0.097 13.1 1.3 9.2 6.8 0.0 3.8 3 0 0 3 3 3 0 Suppressor of RNA silencing P21-like N-terminal domain DUF3464 PF11947.8 AFZ79094.1 - 0.08 12.7 9.6 0.13 12.0 0.3 2.7 1 1 0 2 2 2 0 Photosynthesis affected mutant 68 CX9C PF16860.5 AFZ79096.1 - 0.0015 18.5 2.1 0.0024 17.8 2.1 1.3 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 AFZ79096.1 - 0.0059 16.7 3.0 0.48 10.6 3.2 2.2 1 1 0 1 1 1 1 CHCH domain GCV_H PF01597.19 AFZ79097.1 - 4.8e-06 26.5 0.0 1.3e-05 25.0 0.0 1.7 2 0 0 2 2 2 1 Glycine cleavage H-protein CaKB PF03185.15 AFZ79097.1 - 0.013 15.2 0.1 0.018 14.7 0.1 1.2 1 0 0 1 1 1 0 Calcium-activated potassium channel, beta subunit Ribosomal_L37e PF01907.19 AFZ79098.1 - 3e-24 84.9 5.9 3e-24 84.9 5.9 1.5 2 0 0 2 2 2 1 Ribosomal protein L37e zf-ribbon_3 PF13248.6 AFZ79098.1 - 0.015 14.7 3.7 0.015 14.7 3.7 1.8 2 0 0 2 2 2 0 zinc-ribbon domain zf-RING_5 PF14634.6 AFZ79098.1 - 0.11 12.5 5.0 0.13 12.2 3.4 1.9 2 0 0 2 2 2 0 zinc-RING finger domain HypA PF01155.19 AFZ79098.1 - 0.11 12.5 0.4 0.16 12.0 0.4 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Auto_anti-p27 PF06677.12 AFZ79098.1 - 0.16 12.2 2.0 0.29 11.3 2.0 1.5 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DUF2469 PF10611.9 AFZ79099.1 - 0.16 12.6 1.4 6 7.5 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2469) RNA_pol_N PF01194.17 AFZ79100.1 - 4e-32 110.3 0.7 4.7e-32 110.1 0.7 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.12 AFZ79100.1 - 0.087 13.1 0.6 0.19 12.0 0.6 1.6 1 1 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Nkap_C PF06047.11 AFZ79101.1 - 1.4e-39 134.3 6.7 1.8e-39 133.9 5.1 1.9 2 0 0 2 2 2 1 NF-kappa-B-activating protein C-terminal domain DUF2683 PF10884.8 AFZ79103.1 - 0.078 13.2 1.8 0.086 13.1 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2683) DUF1732 PF08340.11 AFZ79103.1 - 0.12 12.3 0.1 0.23 11.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1732) Pou PF00157.17 AFZ79103.1 - 0.23 11.4 0.6 0.64 10.0 0.0 2.1 3 1 0 3 3 3 0 Pou domain - N-terminal to homeobox domain Kdo PF06293.14 AFZ79104.1 - 5.1e-13 48.9 0.0 1.5e-12 47.3 0.0 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 AFZ79104.1 - 2.7e-10 40.1 0.1 3.3e-10 39.8 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 AFZ79104.1 - 9.6e-10 38.4 0.0 1.3e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 AFZ79104.1 - 2.4e-09 37.5 0.0 2.9e-05 24.1 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 AFZ79104.1 - 2.8e-07 30.1 0.1 3.6e-07 29.7 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase WaaY PF06176.11 AFZ79104.1 - 7.2e-07 29.1 0.1 8.5e-07 28.8 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) EcKinase PF02958.20 AFZ79104.1 - 1.7e-05 24.3 0.0 1.9e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 AFZ79104.1 - 0.00015 21.5 0.1 0.047 13.3 0.0 2.1 1 1 1 2 2 2 2 Choline/ethanolamine kinase DTC PF18102.1 AFZ79104.1 - 0.015 15.5 0.0 0.023 14.8 0.0 1.2 1 0 0 1 1 1 0 Deltex C-terminal domain LepB_N PF18640.1 AFZ79104.1 - 0.022 14.4 0.0 0.034 13.8 0.0 1.3 1 0 0 1 1 1 0 LepB N-terminal domain Seadorna_VP7 PF07387.11 AFZ79104.1 - 0.033 13.3 0.6 0.058 12.4 0.2 1.5 1 1 0 1 1 1 0 Seadornavirus VP7 Fructosamin_kin PF03881.14 AFZ79104.1 - 0.1 11.8 0.0 2.4 7.3 0.0 2.0 1 1 1 2 2 2 0 Fructosamine kinase Pkinase_fungal PF17667.1 AFZ79104.1 - 0.11 11.2 0.1 0.14 10.9 0.1 1.1 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 AFZ79104.1 - 0.13 11.5 0.0 0.32 10.3 0.0 1.6 1 1 1 2 2 2 0 Kinase-like SCO1-SenC PF02630.14 AFZ79105.1 - 2.3e-45 153.8 0.1 2.9e-45 153.5 0.1 1.1 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 AFZ79105.1 - 6.8e-07 29.2 0.1 1.2e-06 28.5 0.1 1.4 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 AFZ79105.1 - 0.00028 21.2 0.1 0.00065 20.0 0.1 1.8 1 1 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 AFZ79105.1 - 0.0036 17.0 0.2 0.041 13.6 0.1 2.3 2 1 0 2 2 2 1 Redoxin Thioredoxin_2 PF13098.6 AFZ79105.1 - 0.051 14.0 0.0 0.096 13.1 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like domain Mu-like_Com PF10122.9 AFZ79105.1 - 0.075 12.5 0.3 0.13 11.7 0.3 1.3 1 0 0 1 1 1 0 Mu-like prophage protein Com HSP70 PF00012.20 AFZ79106.1 - 8e-78 262.1 0.0 1.7e-77 261.0 0.0 1.5 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AFZ79106.1 - 1.5 7.5 3.1 11 4.7 0.0 2.8 2 1 0 2 2 2 0 MreB/Mbl protein HSP90 PF00183.18 AFZ79107.1 - 3.4e-227 755.4 30.2 4.6e-227 755.0 30.2 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 AFZ79107.1 - 9.4e-14 51.9 0.1 1.7e-13 51.0 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 AFZ79107.1 - 5.2e-11 42.5 0.2 1.6e-10 40.9 0.2 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1198 PF06711.11 AFZ79107.1 - 0.16 12.0 1.3 0.68 10.0 0.3 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1198) Arf PF00025.21 AFZ79108.1 - 9.8e-76 253.1 0.5 1.2e-75 252.8 0.5 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 AFZ79108.1 - 1.8e-15 57.2 0.1 2.6e-15 56.7 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 AFZ79108.1 - 2.8e-14 53.0 0.0 3.5e-14 52.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 AFZ79108.1 - 1.5e-13 50.6 1.7 1.9e-08 33.9 0.3 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 AFZ79108.1 - 3.9e-13 49.3 0.1 4.2e-13 49.2 0.1 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 AFZ79108.1 - 3.3e-09 36.5 0.0 4e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 AFZ79108.1 - 8e-06 25.9 0.1 1.2e-05 25.3 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase CRISPR_Cas2 PF09827.9 AFZ79108.1 - 0.0024 18.0 0.1 0.013 15.7 0.0 1.9 2 0 0 2 2 2 1 CRISPR associated protein Cas2 6PF2K PF01591.18 AFZ79108.1 - 0.003 16.9 0.2 0.0048 16.2 0.2 1.4 1 1 0 1 1 1 1 6-phosphofructo-2-kinase AAA_8 PF12780.7 AFZ79108.1 - 0.067 12.5 0.0 0.085 12.2 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region D4 AAA_33 PF13671.6 AFZ79108.1 - 0.094 12.9 0.4 0.26 11.4 0.4 2.0 1 1 0 1 1 1 0 AAA domain AAA_31 PF13614.6 AFZ79108.1 - 0.12 12.3 0.2 0.19 11.6 0.2 1.6 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 AFZ79108.1 - 0.19 10.8 0.3 0.32 10.0 0.3 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Paf67 PF10255.9 AFZ79110.1 - 1.5e-133 445.8 14.1 1.9e-133 445.4 14.1 1.1 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 Transposase_1 PF01359.18 AFZ79110.1 - 0.074 12.9 0.9 0.19 11.6 0.9 1.7 1 0 0 1 1 1 0 Transposase (partial DDE domain) NOG1_N PF17835.1 AFZ79111.1 - 1.5e-46 158.3 0.4 3e-46 157.3 0.4 1.6 1 0 0 1 1 1 1 NOG1 N-terminal helical domain NOG1 PF06858.14 AFZ79111.1 - 1.9e-26 91.6 0.1 1.2e-25 89.0 0.1 2.2 2 0 0 2 2 2 1 Nucleolar GTP-binding protein 1 (NOG1) NOGCT PF08155.11 AFZ79111.1 - 5.1e-23 80.8 0.4 1.1e-22 79.7 0.4 1.6 1 0 0 1 1 1 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.23 AFZ79111.1 - 5.9e-17 61.8 0.0 1.2e-16 60.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AFZ79111.1 - 2.1e-11 43.6 0.0 5e-11 42.4 0.0 1.7 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 AFZ79111.1 - 0.016 15.1 0.1 5.3 6.9 0.0 2.9 2 1 0 2 2 2 0 RsgA GTPase Dynamin_N PF00350.23 AFZ79111.1 - 0.053 13.6 0.4 11 6.0 0.0 2.7 2 1 1 3 3 3 0 Dynamin family G-alpha PF00503.20 AFZ79111.1 - 0.067 12.3 1.9 0.78 8.8 2.0 2.5 1 1 0 1 1 1 0 G-protein alpha subunit AAA_18 PF13238.6 AFZ79111.1 - 0.084 13.4 0.0 0.75 10.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 AFZ79111.1 - 0.12 12.8 0.0 0.32 11.4 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain MMR_HSR1_Xtn PF16897.5 AFZ79111.1 - 0.13 12.2 0.1 0.51 10.4 0.0 2.0 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain AIG1 PF04548.16 AFZ79111.1 - 0.15 11.3 0.0 0.32 10.3 0.0 1.5 1 0 0 1 1 1 0 AIG1 family LRR_4 PF12799.7 AFZ79112.1 - 1.3e-09 38.2 17.9 0.00014 22.1 0.3 5.4 2 2 4 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 AFZ79112.1 - 0.00027 20.6 15.4 0.053 13.3 2.3 4.6 3 2 1 4 4 4 2 Leucine rich repeat LRR_9 PF14580.6 AFZ79112.1 - 0.0014 18.1 3.5 0.056 12.9 0.2 2.6 1 1 2 3 3 3 2 Leucine-rich repeat OSCP PF00213.18 AFZ79112.1 - 0.095 12.8 0.1 0.43 10.7 0.1 1.9 1 1 0 1 1 1 0 ATP synthase delta (OSCP) subunit LRR_1 PF00560.33 AFZ79112.1 - 2.1 9.2 12.4 20 6.2 1.1 6.3 5 2 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.6 AFZ79112.1 - 2.2 8.6 10.9 39 4.7 0.3 5.5 5 0 0 5 5 5 0 Leucine Rich repeat Tsi6 PF18660.1 AFZ79113.1 - 0.06 13.4 1.6 0.14 12.2 0.2 2.5 2 1 0 2 2 2 0 Tsi6 Cob_adeno_trans PF01923.18 AFZ79113.1 - 0.24 11.5 5.1 1.5 8.9 0.5 3.0 1 1 0 3 3 3 0 Cobalamin adenosyltransferase FRB_dom PF08771.11 AFZ79113.1 - 0.44 11.0 8.0 0.73 10.3 1.6 3.5 2 1 1 3 3 3 0 FKBP12-rapamycin binding domain DUF4407 PF14362.6 AFZ79113.1 - 0.53 9.6 9.7 3.2 7.0 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) AHH PF14412.6 AFZ79113.1 - 1.1 9.3 6.0 0.71 9.9 0.6 2.8 3 0 0 3 3 3 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH ISG65-75 PF11727.8 AFZ79113.1 - 4.2 6.5 17.2 0.22 10.7 4.4 2.6 3 0 0 3 3 3 0 Invariant surface glycoprotein GNAT_acetyltr_2 PF13718.6 AFZ79114.1 - 6.6e-73 244.9 0.2 2e-72 243.3 0.0 1.9 2 0 0 2 2 2 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.14 AFZ79114.1 - 5.2e-49 166.5 0.0 1.2e-48 165.3 0.0 1.7 2 0 0 2 2 2 1 Helicase tRNA_bind_2 PF13725.6 AFZ79114.1 - 5.5e-40 137.5 0.3 1.2e-39 136.5 0.3 1.5 1 0 0 1 1 1 1 Possible tRNA binding domain DUF1726 PF08351.11 AFZ79114.1 - 3.5e-31 107.0 0.0 1.2e-30 105.3 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) NDC10_II PF16787.5 AFZ79114.1 - 0.071 12.1 0.0 0.16 11.0 0.0 1.6 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit, domain 2 ATP-synt_DE_N PF02823.16 AFZ79116.1 - 1.8e-13 50.2 0.0 2.6e-13 49.7 0.0 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Ion_trans_2 PF07885.16 AFZ79119.1 - 1.4e-09 37.7 8.2 6.2e-09 35.7 8.2 2.2 1 0 0 1 1 1 1 Ion channel BK_channel_a PF03493.18 AFZ79119.1 - 4.6e-07 29.9 0.3 1.6e-06 28.2 0.3 2.0 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit M16C_assoc PF08367.11 AFZ79121.1 - 5.4e-42 143.7 3.3 4.1e-41 140.8 2.1 2.4 3 0 0 3 3 3 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 AFZ79121.1 - 5.6e-19 68.9 0.1 2.9e-15 56.8 0.0 3.1 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 AFZ79121.1 - 5.5e-09 36.2 0.0 5.3e-07 29.7 0.0 2.6 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Uricase PF01014.18 AFZ79121.1 - 0.12 12.6 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 Uricase AvrM-A PF18241.1 AFZ79121.1 - 0.17 12.3 2.0 18 5.7 0.0 3.1 3 0 0 3 3 3 0 Flax-rust effector AvrM-A Abhydrolase_6 PF12697.7 AFZ79122.1 - 7.1e-12 46.4 0.0 1.2e-11 45.6 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AFZ79122.1 - 4.7e-07 29.3 0.3 1.6e-06 27.6 0.3 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 AFZ79122.1 - 6.7e-05 22.7 0.0 0.0001 22.1 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 AFZ79122.1 - 0.004 17.0 0.5 1.5 8.5 0.0 3.2 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase Thioesterase PF00975.20 AFZ79122.1 - 0.0045 17.1 0.0 0.014 15.6 0.0 1.8 1 1 0 1 1 1 1 Thioesterase domain Lipase_3 PF01764.25 AFZ79122.1 - 0.015 15.1 0.0 0.034 14.0 0.0 1.7 1 1 0 1 1 1 0 Lipase (class 3) BAAT_C PF08840.11 AFZ79122.1 - 0.027 14.4 0.0 0.05 13.5 0.0 1.4 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal TryThrA_C PF12319.8 AFZ79122.1 - 0.064 12.7 0.1 0.11 11.9 0.1 1.3 1 0 0 1 1 1 0 Tryptophan-Threonine-rich plasmodium antigen C terminal zf-MIZ PF02891.20 AFZ79123.1 - 9.7e-20 70.1 1.1 9.7e-20 70.1 1.1 1.9 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 AFZ79123.1 - 0.00043 20.0 1.2 0.002 17.9 1.2 2.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit PINIT PF14324.6 AFZ79123.1 - 0.014 15.7 0.8 0.035 14.4 0.6 1.8 1 1 0 1 1 1 0 PINIT domain PHD PF00628.29 AFZ79123.1 - 0.019 14.9 16.8 0.2 11.6 8.5 2.5 2 0 0 2 2 2 0 PHD-finger FYVE_2 PF02318.16 AFZ79123.1 - 0.052 13.8 3.6 0.18 12.0 3.6 2.0 1 0 0 1 1 1 0 FYVE-type zinc finger E2_bind PF08825.10 AFZ79123.1 - 0.056 13.6 0.5 9.2 6.5 0.3 2.6 2 0 0 2 2 2 0 E2 binding domain DUF1053 PF06327.14 AFZ79123.1 - 1.1 9.9 6.0 18 5.9 0.1 3.4 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1053) zinc_ribbon_10 PF10058.9 AFZ79123.1 - 4.3 7.1 9.7 3.8 7.3 0.1 2.7 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Zf_RING PF16744.5 AFZ79123.1 - 4.6 7.4 9.3 4.3 7.5 4.9 2.5 2 0 0 2 2 2 0 KIAA1045 RING finger Cas_Csa4 PF09703.10 AFZ79124.1 - 0.032 13.6 0.1 2.7 7.2 0.0 2.7 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csa4) EMC3_TMCO1 PF01956.16 AFZ79126.1 - 2.2e-13 50.3 1.8 2.2e-13 50.3 1.8 1.5 2 0 0 2 2 2 1 Integral membrane protein EMC3/TMCO1-like RRM_1 PF00076.22 AFZ79127.1 - 8.8e-18 63.9 0.0 1.5e-17 63.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Arr-ms PF12120.8 AFZ79127.1 - 0.042 14.0 0.0 0.22 11.7 0.0 2.1 3 0 0 3 3 3 0 Rifampin ADP-ribosyl transferase DUF900 PF05990.12 AFZ79129.1 - 3.5e-12 46.3 0.0 5.5e-11 42.4 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF900) IGPS PF00218.21 AFZ79131.1 - 2.1e-25 89.4 0.3 5.7e-25 87.9 0.1 1.8 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase DHO_dh PF01180.21 AFZ79131.1 - 0.016 14.5 0.0 0.033 13.4 0.0 1.5 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase eIF3_N PF09440.10 AFZ79131.1 - 1.5 9.3 5.7 0.24 11.8 0.3 2.4 3 0 0 3 3 3 0 eIF3 subunit 6 N terminal domain PUL PF08324.11 AFZ79132.1 - 4.2e-15 55.7 4.4 6.5e-15 55.1 4.4 1.2 1 0 0 1 1 1 1 PUL domain WD40 PF00400.32 AFZ79132.1 - 7.1e-13 48.8 4.0 0.00015 22.4 0.2 5.4 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 AFZ79132.1 - 0.00014 20.7 0.0 0.00029 19.6 0.0 1.6 1 0 0 1 1 1 1 Nucleoporin Nup120/160 DUF3369 PF11849.8 AFZ79132.1 - 0.0061 16.8 4.6 0.072 13.3 1.4 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3369) IMD PF08397.11 AFZ79132.1 - 0.045 13.1 0.4 0.082 12.3 0.4 1.3 1 0 0 1 1 1 0 IRSp53/MIM homology domain Phage_HK97_TLTM PF06120.11 AFZ79132.1 - 0.22 10.7 1.1 0.34 10.0 1.1 1.3 1 0 0 1 1 1 0 Tail length tape measure protein Ribosomal_L9_N PF01281.19 AFZ79133.1 - 3.7e-14 52.0 0.0 5.8e-14 51.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain DUF2439 PF10382.9 AFZ79135.1 - 1.4e-07 31.8 0.8 3.5e-07 30.4 0.8 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF2439) DNA_pol_E_B PF04042.16 AFZ79136.1 - 3.8e-23 82.0 0.1 5.8e-23 81.3 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DUF5370 PF17340.2 AFZ79136.1 - 0.026 14.4 1.3 3.2 7.7 0.3 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5370) BAR_3 PF16746.5 AFZ79137.1 - 0.0048 16.6 4.2 0.23 11.1 0.0 2.8 1 1 1 2 2 2 2 BAR domain of APPL family DUF4776 PF16003.5 AFZ79137.1 - 0.095 11.7 1.4 0.17 10.9 1.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) NACHT PF05729.12 AFZ79138.1 - 0.0039 17.1 0.0 0.0069 16.3 0.0 1.5 1 0 0 1 1 1 1 NACHT domain PhoH PF02562.16 AFZ79138.1 - 0.011 15.2 0.0 0.017 14.5 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein AAA_14 PF13173.6 AFZ79138.1 - 0.012 15.7 0.2 0.054 13.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain Bac_DnaA PF00308.18 AFZ79138.1 - 0.016 15.1 0.0 0.034 14.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein ATPase_2 PF01637.18 AFZ79138.1 - 0.031 14.2 0.8 0.074 12.9 0.0 2.0 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 AFZ79138.1 - 0.12 12.7 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain GH43_C2 PF17851.1 AFZ79138.1 - 0.12 12.1 0.2 0.22 11.2 0.2 1.3 1 0 0 1 1 1 0 Beta xylosidase C-terminal Concanavalin A-like domain cobW PF02492.19 AFZ79138.1 - 0.15 11.6 0.1 0.24 11.0 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 AFZ79138.1 - 0.16 12.4 0.0 0.27 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain RAWUL PF16207.5 AFZ79138.1 - 0.4 11.4 2.0 35 5.2 0.1 3.3 3 0 0 3 3 3 0 RAWUL domain RING finger- and WD40-associated ubiquitin-like DnaJ_C PF01556.18 AFZ79139.1 - 2.3e-17 63.5 0.2 2.6e-16 60.0 0.1 2.1 1 1 1 2 2 2 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 AFZ79139.1 - 8.3e-08 32.5 14.9 1.5e-07 31.7 14.9 1.4 1 0 0 1 1 1 1 DnaJ central domain DnaJ PF00226.31 AFZ79139.1 - 5.1e-07 29.7 1.6 1.7e-06 28.0 1.6 2.0 1 1 0 1 1 1 1 DnaJ domain DUF2318 PF10080.9 AFZ79139.1 - 0.054 13.6 5.8 2.1 8.5 0.7 2.5 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) DUF5351 PF17302.2 AFZ79139.1 - 0.5 10.6 9.1 4 7.7 2.1 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5351) Anti-TRAP PF15777.5 AFZ79139.1 - 1.5 8.8 10.2 1.4 8.9 1.4 2.5 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein Fis1_TPR_C PF14853.6 AFZ79140.1 - 5.9e-10 39.1 1.2 9.7e-10 38.4 1.2 1.4 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat TPR_2 PF07719.17 AFZ79140.1 - 7.8e-05 22.5 1.2 0.00029 20.7 0.1 2.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 AFZ79140.1 - 0.00014 22.3 0.1 0.0056 17.2 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 AFZ79140.1 - 0.00019 21.6 0.7 0.00048 20.3 0.6 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 AFZ79140.1 - 0.0013 18.5 0.2 0.0026 17.5 0.2 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 AFZ79140.1 - 0.015 15.8 0.0 0.028 14.9 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 AFZ79140.1 - 0.022 15.4 0.0 0.1 13.2 0.0 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 AFZ79140.1 - 0.074 13.9 0.1 0.37 11.7 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_N PF14852.6 AFZ79140.1 - 0.077 12.7 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Fis1 N-terminal tetratricopeptide repeat Ribosomal_L39 PF00832.20 AFZ79141.1 - 2.7e-21 74.9 12.0 3.1e-21 74.7 12.0 1.0 1 0 0 1 1 1 1 Ribosomal L39 protein RNase_P_Rpp14 PF01900.19 AFZ79142.1 - 0.015 15.5 0.0 0.02 15.1 0.0 1.3 1 0 0 1 1 1 0 Rpp14/Pop5 family DUF747 PF05346.11 AFZ79144.1 - 3.8e-28 98.9 1.5 4.2e-28 98.7 1.5 1.0 1 0 0 1 1 1 1 Eukaryotic membrane protein family DUF747 PF05346.11 AFZ79145.1 - 4.2e-65 220.3 6.3 6.3e-65 219.7 6.3 1.2 1 0 0 1 1 1 1 Eukaryotic membrane protein family DEAD PF00270.29 AFZ79146.1 - 3.6e-36 124.5 0.1 5.9e-36 123.9 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AFZ79146.1 - 2.2e-22 79.5 3.7 1.8e-21 76.6 0.0 3.3 1 1 1 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AFZ79146.1 - 0.035 14.1 0.0 0.14 12.1 0.0 2.1 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit TnpW PF14202.6 AFZ79146.1 - 0.12 12.2 0.2 0.26 11.2 0.2 1.5 1 0 0 1 1 1 0 Transposon-encoded protein TnpW AAA_22 PF13401.6 AFZ79146.1 - 0.18 12.1 0.5 2.9 8.1 0.5 2.6 1 1 0 1 1 1 0 AAA domain SNF2_N PF00176.23 AFZ79146.1 - 0.45 9.2 3.7 0.23 10.1 0.2 2.1 3 0 0 3 3 3 0 SNF2 family N-terminal domain Exo_endo_phos PF03372.23 AFZ79147.1 - 6.6e-11 42.2 0.0 1.4e-10 41.1 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF3336 PF11815.8 AFZ79147.1 - 0.074 12.8 0.2 0.23 11.2 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3336) UQ_con PF00179.26 AFZ79148.1 - 4.5e-45 152.7 0.0 5.2e-45 152.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 AFZ79148.1 - 0.0014 18.3 0.0 0.0017 18.0 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 AFZ79148.1 - 0.0054 17.0 0.0 0.0079 16.5 0.0 1.2 1 0 0 1 1 1 1 RWD domain Cpn60_TCP1 PF00118.24 AFZ79149.1 - 8.6e-151 502.9 8.8 9.7e-151 502.7 8.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Synaptobrevin PF00957.21 AFZ79150.1 - 4.1e-19 68.2 0.3 6.8e-19 67.5 0.3 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 AFZ79150.1 - 1.8e-16 59.9 0.3 3e-16 59.2 0.3 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain IPP-2 PF04979.14 AFZ79151.1 - 4.6e-12 46.8 12.2 1.4e-10 42.1 12.2 2.1 1 1 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) HA2 PF04408.23 AFZ79153.1 - 2.9e-17 62.9 0.0 6.9e-17 61.7 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 AFZ79153.1 - 1.3e-14 54.3 0.4 2.6e-13 50.1 0.4 2.3 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 AFZ79153.1 - 9.2e-14 51.7 2.7 2e-11 44.2 0.1 3.7 3 2 0 3 3 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 AFZ79153.1 - 1.1e-10 41.6 0.5 6.3e-10 39.1 0.2 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 AFZ79153.1 - 1.8e-05 24.8 0.2 6.7e-05 23.0 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 AFZ79153.1 - 3.9e-05 24.0 0.1 0.00013 22.2 0.1 1.9 1 1 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 AFZ79153.1 - 4.9e-05 23.3 0.0 0.00012 22.1 0.0 1.7 2 0 0 2 2 1 1 Flavivirus DEAD domain ABC_tran PF00005.27 AFZ79153.1 - 5e-05 23.8 0.2 0.00081 19.9 0.1 2.7 2 1 0 2 2 2 1 ABC transporter AAA_23 PF13476.6 AFZ79153.1 - 0.00035 21.1 2.0 0.0029 18.2 2.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 AFZ79153.1 - 0.0011 18.7 0.0 0.0031 17.2 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 AFZ79153.1 - 0.0012 18.6 0.0 0.0025 17.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 AFZ79153.1 - 0.0027 17.6 0.0 0.015 15.1 0.0 2.3 3 0 0 3 3 2 1 Helicase T2SSE PF00437.20 AFZ79153.1 - 0.0033 16.5 0.0 0.0069 15.5 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein RsgA_GTPase PF03193.16 AFZ79153.1 - 0.0035 17.2 0.0 0.0089 15.9 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase AAA_19 PF13245.6 AFZ79153.1 - 0.0096 16.3 0.0 0.021 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 AFZ79153.1 - 0.022 14.8 0.4 0.32 11.0 0.4 2.5 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 AFZ79153.1 - 0.024 13.9 0.6 0.042 13.1 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 AFZ79153.1 - 0.024 14.1 0.1 0.09 12.2 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein NB-ARC PF00931.22 AFZ79153.1 - 0.026 13.7 0.1 0.053 12.7 0.1 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_16 PF13191.6 AFZ79153.1 - 0.034 14.5 0.0 0.066 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain cobW PF02492.19 AFZ79153.1 - 0.041 13.5 0.1 0.39 10.3 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TarS_C1 PF18674.1 AFZ79153.1 - 0.055 13.4 0.0 0.2 11.6 0.0 1.9 2 0 0 2 2 1 0 TarS beta-glycosyltransferase C-terminal domain 1 Sigma54_activat PF00158.26 AFZ79153.1 - 0.095 12.4 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 AFZ79153.1 - 0.12 11.7 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin DUF87 PF01935.17 AFZ79153.1 - 0.14 12.3 1.7 0.59 10.2 0.0 2.6 3 0 0 3 3 2 0 Helicase HerA, central domain DUF1754 PF08555.10 AFZ79155.1 - 1.4 9.7 12.0 9.8 7.0 12.0 2.1 1 1 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) L51_S25_CI-B8 PF05047.16 AFZ79157.1 - 4.1e-06 26.6 0.0 1e-05 25.3 0.0 1.7 2 0 0 2 2 2 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Rpn3_C PF08375.11 AFZ79157.1 - 0.093 13.2 0.2 20 5.7 0.1 2.4 2 0 0 2 2 2 0 Proteasome regulatory subunit C-terminal Ribosomal_S17_N PF16205.5 AFZ79158.1 - 1.3e-27 95.9 1.1 2.3e-27 95.1 1.1 1.4 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 AFZ79158.1 - 7.7e-26 90.0 0.5 7.7e-26 90.0 0.5 1.5 2 0 0 2 2 2 1 Ribosomal protein S17 Nas2_N PF18265.1 AFZ79160.1 - 2.5e-26 91.4 0.1 2.8e-26 91.2 0.1 1.0 1 0 0 1 1 1 1 Nas2 N_terminal domain UPA_2 PF17809.1 AFZ79160.1 - 0.0022 17.8 0.1 0.0066 16.3 0.0 1.7 2 0 0 2 2 2 1 UPA domain CHMI PF02962.15 AFZ79160.1 - 0.12 12.7 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 5-carboxymethyl-2-hydroxymuconate isomerase COX4 PF02936.14 AFZ79163.1 - 0.031 14.3 0.0 0.057 13.4 0.0 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV DUF4491 PF14898.6 AFZ79167.1 - 9.4 6.8 7.9 2.6e+02 2.1 8.3 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4491) CSN8_PSD8_EIF3K PF10075.9 AFZ79168.1 - 1.1e-20 74.1 0.0 1.7e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family PCI PF01399.27 AFZ79168.1 - 0.054 14.0 0.1 0.11 13.0 0.1 1.6 1 0 0 1 1 1 0 PCI domain Adaptin_N PF01602.20 AFZ79169.1 - 7.1e-122 407.6 12.7 8.8e-122 407.3 12.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 AFZ79169.1 - 5e-57 192.5 0.8 5e-57 192.5 0.8 2.8 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 AFZ79169.1 - 1.5e-12 47.8 3.0 1.3e-06 28.7 0.0 5.3 3 1 2 5 5 5 2 HEAT repeats HEAT PF02985.22 AFZ79169.1 - 9.6e-11 41.0 2.9 0.016 15.4 0.0 6.1 5 0 0 5 5 5 2 HEAT repeat B2-adapt-app_C PF09066.10 AFZ79169.1 - 4.4e-06 26.7 0.0 1.8e-05 24.8 0.0 2.1 2 0 0 2 2 2 1 Beta2-adaptin appendage, C-terminal sub-domain Arm PF00514.23 AFZ79169.1 - 1.6e-05 24.7 0.6 0.0016 18.4 0.0 4.1 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 AFZ79169.1 - 0.00012 21.7 1.0 0.29 10.6 0.0 2.4 1 1 0 2 2 2 2 Armadillo-like RTP1_C1 PF10363.9 AFZ79169.1 - 0.0014 18.8 0.7 0.097 12.9 0.0 3.5 1 1 2 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 Atx10homo_assoc PF09759.9 AFZ79169.1 - 0.0018 18.2 0.0 0.84 9.7 0.0 3.8 2 1 1 3 3 3 1 Spinocerebellar ataxia type 10 protein domain CLASP_N PF12348.8 AFZ79169.1 - 0.032 13.8 0.1 1.3 8.5 0.0 3.2 3 1 1 4 4 4 0 CLASP N terminal Alpha_adaptinC2 PF02883.20 AFZ79169.1 - 0.053 13.8 0.1 0.1 12.9 0.1 1.4 1 0 0 1 1 1 0 Adaptin C-terminal domain Ribosomal_L7Ae PF01248.26 AFZ79170.1 - 1.6e-22 79.0 0.0 2.1e-22 78.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PhetRS_B1 PF18262.1 AFZ79171.1 - 0.14 12.4 0.5 0.54 10.5 0.5 2.1 1 1 0 1 1 1 0 Phe-tRNA synthetase beta subunit B1 domain JAB PF01398.21 AFZ79172.1 - 3.2e-08 33.5 0.0 3.6e-06 26.9 0.0 2.4 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Syntaxin-5_N PF11416.8 AFZ79173.1 - 0.14 11.4 0.0 0.25 10.6 0.0 1.4 1 0 0 1 1 1 0 Syntaxin-5 N-terminal, Sly1p-binding domain tRNA-synt_1 PF00133.22 AFZ79174.1 - 1.3e-207 690.8 0.2 1.7e-207 690.4 0.2 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 AFZ79174.1 - 6.5e-22 78.1 0.0 1.4e-21 77.1 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 AFZ79174.1 - 2.6e-15 56.1 4.6 0.00012 21.0 0.1 4.0 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 AFZ79174.1 - 0.013 14.9 0.0 0.029 13.7 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain Cpn10 PF00166.21 AFZ79175.1 - 4.3e-29 100.4 0.0 1e-14 54.3 0.0 2.1 2 0 0 2 2 2 2 Chaperonin 10 Kd subunit NTP_transf_2 PF01909.23 AFZ79176.1 - 2.4e-08 34.1 0.0 8.6e-08 32.4 0.0 2.0 2 0 0 2 2 2 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 AFZ79176.1 - 0.011 16.0 0.3 0.027 14.7 0.3 1.8 1 0 0 1 1 1 0 Cid1 family poly A polymerase DNA_pol_B_palm PF14792.6 AFZ79176.1 - 0.13 12.5 0.0 0.32 11.2 0.0 1.7 1 0 0 1 1 1 0 DNA polymerase beta palm Sedlin_N PF04628.13 AFZ79177.1 - 1.3e-38 132.1 0.0 1.6e-38 131.8 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Laminin_I PF06008.14 AFZ79178.1 - 0.0064 16.2 1.9 0.012 15.3 1.9 1.4 1 0 0 1 1 1 1 Laminin Domain I CC2-LZ PF16516.5 AFZ79178.1 - 0.49 10.8 7.8 0.14 12.6 3.9 2.1 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator ZapB PF06005.12 AFZ79178.1 - 8.6 6.9 8.3 1.7 9.2 0.2 3.1 2 1 1 3 3 3 0 Cell division protein ZapB RAP PF08373.10 AFZ79180.1 - 0.00073 19.6 0.1 0.0028 17.7 0.1 2.1 1 0 0 1 1 1 1 RAP domain FAST_1 PF06743.15 AFZ79180.1 - 0.00087 19.2 1.0 0.14 12.2 0.1 3.8 4 0 0 4 4 4 1 FAST kinase-like protein, subdomain 1 TRAPP PF04051.16 AFZ79181.1 - 3.5e-22 78.7 0.0 4e-22 78.5 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component DEAD PF00270.29 AFZ79182.1 - 8.3e-45 152.7 0.0 4e-44 150.5 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AFZ79182.1 - 1.9e-31 108.6 0.0 5.6e-31 107.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AFZ79182.1 - 7.5e-05 22.8 0.0 0.0002 21.4 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 AFZ79182.1 - 0.069 12.4 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 SecA DEAD-like domain RNase_E_G PF10150.9 AFZ79182.1 - 0.082 12.3 0.1 0.15 11.4 0.1 1.4 1 0 0 1 1 1 0 Ribonuclease E/G family zf-CCHC_4 PF14392.6 AFZ79182.1 - 0.44 10.3 6.3 0.73 9.6 2.9 2.4 2 0 0 2 2 2 0 Zinc knuckle Ribosomal_L27A PF00828.19 AFZ79183.1 - 1.8e-23 83.6 0.5 2.4e-23 83.2 0.5 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A RTC4 PF14474.6 AFZ79183.1 - 0.12 12.5 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 RTC4-like domain Nucleoporin_FG PF13634.6 AFZ79184.1 - 7e-26 90.9 184.7 1.5e-08 35.4 35.6 5.3 2 2 3 5 5 5 5 Nucleoporin FG repeat region Thymidylate_kin PF02223.17 AFZ79185.1 - 7.1e-36 123.6 0.0 8.1e-36 123.4 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase AAA_18 PF13238.6 AFZ79185.1 - 0.12 12.9 0.0 0.19 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain PPK2 PF03976.14 AFZ79185.1 - 0.12 11.8 0.0 0.24 10.9 0.0 1.5 2 0 0 2 2 2 0 Polyphosphate kinase 2 (PPK2) Pkinase PF00069.25 AFZ79186.1 - 4.5e-54 183.6 0.0 4.8e-41 140.9 0.0 2.2 1 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ79186.1 - 4.4e-25 88.4 0.0 1.7e-24 86.5 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 AFZ79186.1 - 0.02 14.5 0.2 0.73 9.4 0.1 2.4 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 AFZ79186.1 - 0.023 14.6 0.0 0.25 11.2 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 AFZ79186.1 - 0.03 13.1 0.0 0.051 12.3 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase YrbL-PhoP_reg PF10707.9 AFZ79186.1 - 0.11 12.1 0.0 0.25 10.8 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL MSP7_C PF12948.7 AFZ79187.1 - 0.00051 20.7 0.2 0.5 11.0 0.0 2.5 2 0 0 2 2 2 2 MSP7-like protein C-terminal domain PTPLA PF04387.14 AFZ79188.1 - 1.1e-06 28.5 5.1 1.1e-06 28.5 5.1 2.0 1 1 2 3 3 3 1 Protein tyrosine phosphatase-like protein, PTPLA tRNA-synt_1c PF00749.21 AFZ79189.1 - 2.8e-100 335.2 0.0 4.2e-100 334.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 AFZ79189.1 - 2.7e-40 138.1 0.0 4.7e-40 137.3 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain Ribosomal_L14 PF00238.19 AFZ79190.1 - 7.7e-35 119.6 0.0 9.2e-35 119.4 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e SNARE PF05739.19 AFZ79191.1 - 4.3e-08 33.0 0.2 4.3e-08 33.0 0.2 3.1 4 0 0 4 4 4 1 SNARE domain Baculo_PEP_C PF04513.12 AFZ79191.1 - 0.57 10.2 15.3 1.7 8.7 6.6 2.8 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FlxA PF14282.6 AFZ79191.1 - 1.1 9.3 12.7 0.68 10.0 1.6 3.1 1 1 2 3 3 3 0 FlxA-like protein FUSC PF04632.12 AFZ79191.1 - 2 6.9 5.0 4.1 5.8 1.8 1.8 1 1 1 2 2 2 0 Fusaric acid resistance protein family Uso1_p115_C PF04871.13 AFZ79191.1 - 2.4 8.6 10.4 3.4 8.1 5.1 2.4 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Syntaxin-6_N PF09177.11 AFZ79191.1 - 3.4 8.3 11.5 21 5.8 6.4 3.0 2 1 1 3 3 3 0 Syntaxin 6, N-terminal Fra10Ac1 PF09725.9 AFZ79192.1 - 3.5e-41 140.2 5.7 5.2e-41 139.6 5.7 1.3 1 0 0 1 1 1 1 Folate-sensitive fragile site protein Fra10Ac1 DUF3161 PF11362.8 AFZ79193.1 - 3.9e-36 122.9 0.8 7.7e-36 121.9 0.4 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3161) SKA2 PF16740.5 AFZ79193.1 - 8e-08 32.0 2.5 1.4e-07 31.3 0.5 2.1 2 0 0 2 2 2 1 Spindle and kinetochore-associated protein 2 SKA1 PF07160.12 AFZ79193.1 - 7.8e-06 25.9 2.0 1.7e-05 24.8 2.0 1.7 1 1 0 1 1 1 1 Spindle and kinetochore-associated protein 1 NBP1 PF08537.10 AFZ79193.1 - 0.23 10.8 5.2 1.6 8.1 1.4 2.1 1 1 1 2 2 2 0 Fungal Nap binding protein NBP1 LCCL PF03815.19 AFZ79194.1 - 1.1e-23 83.1 1.1 1.1e-23 83.1 1.1 2.2 2 0 0 2 2 2 1 LCCL domain F5_F8_type_C PF00754.25 AFZ79194.1 - 4e-18 65.8 0.3 2.1e-09 37.6 0.1 2.7 2 0 0 2 2 2 2 F5/8 type C domain Ricin_B_lectin PF00652.22 AFZ79194.1 - 4.3e-08 33.5 0.4 4.3e-08 33.5 0.4 2.2 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain COLFI PF01410.18 AFZ79194.1 - 3.5e-06 26.5 0.1 1.2e-05 24.7 0.1 1.9 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain DUF1080 PF06439.11 AFZ79194.1 - 0.00014 22.0 1.0 0.0079 16.3 0.5 2.6 3 0 0 3 3 3 1 Domain of Unknown Function (DUF1080) Fibrinogen_C PF00147.18 AFZ79194.1 - 0.0038 17.1 0.6 0.035 13.9 0.0 2.5 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain IIGP PF05049.13 AFZ79194.1 - 0.011 14.8 0.8 0.022 13.8 0.8 1.5 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Rxt3 PF08642.10 AFZ79194.1 - 0.021 15.6 0.0 0.061 14.1 0.0 1.8 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 Bromodomain PF00439.25 AFZ79195.1 - 1.2e-14 54.1 1.2 1.2e-14 54.1 1.2 1.8 2 0 0 2 2 2 1 Bromodomain DUF4804 PF16062.5 AFZ79195.1 - 0.0004 19.3 0.0 0.00054 18.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4804) Pox_MCEL PF03291.16 AFZ79196.1 - 1.3e-37 129.6 1.2 1.3e-37 129.6 1.2 1.4 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 AFZ79196.1 - 9.8e-14 51.8 0.0 4.4e-13 49.8 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 AFZ79196.1 - 8.3e-12 45.2 0.0 2.1e-11 43.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AFZ79196.1 - 5.8e-11 42.9 0.0 1.6e-10 41.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AFZ79196.1 - 3.4e-10 40.5 0.1 1.3e-09 38.7 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 AFZ79196.1 - 2.2e-07 30.9 0.0 6.4e-07 29.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain mRNA_triPase PF02940.15 AFZ79196.1 - 5.1e-07 29.6 0.3 1.4e-06 28.2 0.0 1.8 2 0 0 2 2 2 1 mRNA capping enzyme, beta chain CMAS PF02353.20 AFZ79196.1 - 0.00095 18.5 0.0 0.0018 17.6 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase DUF3577 PF12101.8 AFZ79196.1 - 0.0097 15.7 0.0 0.078 12.8 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3577) MetW PF07021.12 AFZ79196.1 - 0.064 12.9 0.0 0.15 11.6 0.0 1.7 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW TPMT PF05724.11 AFZ79196.1 - 0.11 12.2 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) EMP24_GP25L PF01105.24 AFZ79197.1 - 1.3e-21 77.4 0.0 1.6e-21 77.1 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD ThiF PF00899.21 AFZ79198.1 - 2.7e-45 154.6 0.0 7.3e-39 133.6 0.0 2.9 1 1 2 3 3 3 2 ThiF family UBA_e1_thiolCys PF10585.9 AFZ79198.1 - 3.2e-10 40.4 0.8 1.9e-05 24.7 0.2 2.4 2 0 0 2 2 2 2 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.20 AFZ79198.1 - 1.3e-07 31.7 0.0 0.00056 20.0 0.0 2.7 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase E3_UFM1_ligase PF09743.9 AFZ79198.1 - 0.019 14.6 0.1 0.78 9.3 0.0 2.3 2 0 0 2 2 2 0 E3 UFM1-protein ligase 1 Cor1 PF04803.12 AFZ79198.1 - 0.12 12.6 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 Cor1/Xlr/Xmr conserved region DEAD PF00270.29 AFZ79199.1 - 2.4e-37 128.4 0.0 9.6e-37 126.4 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AFZ79199.1 - 6.3e-31 107.0 0.7 5.5e-30 104.0 0.1 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AFZ79199.1 - 0.0045 17.0 0.0 0.017 15.1 0.0 2.0 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit eIF-6 PF01912.18 AFZ79200.1 - 1.1e-74 250.1 1.3 1.6e-74 249.6 1.3 1.2 1 0 0 1 1 1 1 eIF-6 family TypeIII_RM_meth PF12564.8 AFZ79200.1 - 0.12 12.5 0.1 0.54 10.4 0.1 2.2 1 1 0 1 1 1 0 Type III restriction/modification enzyme methylation subunit AP_endonuc_2 PF01261.24 AFZ79201.1 - 3.8e-33 114.7 0.0 6.1e-33 114.0 0.0 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Voldacs PF03517.13 AFZ79203.1 - 7.5e-20 71.5 3.6 5.5e-18 65.4 3.6 2.2 1 1 0 1 1 1 1 Regulator of volume decrease after cellular swelling BBL5 PF07289.11 AFZ79203.1 - 4.5e-05 22.7 0.0 6.3e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Bardet-Biedl syndrome 5 protein Vps36_ESCRT-II PF11605.8 AFZ79203.1 - 0.00089 19.4 0.1 0.0012 19.0 0.1 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 PH_TFIIH PF08567.11 AFZ79203.1 - 0.039 14.3 0.0 0.068 13.5 0.0 1.4 1 0 0 1 1 1 0 TFIIH p62 subunit, N-terminal domain GRAM PF02893.20 AFZ79203.1 - 0.077 12.9 0.1 0.12 12.3 0.1 1.4 1 1 0 1 1 1 0 GRAM domain Phage_Gp111 PF07410.11 AFZ79204.1 - 0.071 13.6 0.6 0.12 12.8 0.6 1.4 1 0 0 1 1 1 0 Streptococcus thermophilus bacteriophage Gp111 protein FeoB_Cyto PF17910.1 AFZ79204.1 - 0.083 13.5 3.4 0.17 12.5 3.2 1.7 2 1 0 2 2 2 0 FeoB cytosolic helical domain DUF445 PF04286.12 AFZ79204.1 - 0.088 12.6 6.3 0.11 12.2 6.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) CRS1_YhbY PF01985.21 AFZ79204.1 - 0.54 10.5 4.1 0.37 11.0 1.2 2.1 3 0 0 3 3 3 0 CRS1 / YhbY (CRM) domain RecG_N PF17190.4 AFZ79204.1 - 0.87 10.4 6.1 0.7 10.7 2.2 2.2 2 0 0 2 2 2 0 RecG N-terminal helical domain WD40 PF00400.32 AFZ79205.1 - 9.7e-11 42.1 17.8 1.5 9.8 0.1 8.9 9 0 0 9 9 9 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AFZ79205.1 - 9.3e-10 38.7 0.0 1.2 9.5 0.0 7.0 4 1 2 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 AFZ79205.1 - 0.0015 17.6 0.4 0.13 11.2 0.0 3.0 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein RAB3GAP2_N PF14655.6 AFZ79205.1 - 0.082 12.1 0.2 18 4.5 0.0 3.4 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Atg8 PF02991.16 AFZ79206.1 - 1.4e-21 76.6 0.4 2.3e-21 75.9 0.4 1.3 1 1 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 AFZ79206.1 - 0.0043 17.4 0.3 0.0087 16.4 0.3 1.6 1 1 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 tRNA_Me_trans PF03054.16 AFZ79207.1 - 1.9e-96 322.9 0.0 2.8e-96 322.4 0.0 1.2 1 0 0 1 1 1 1 tRNA methyl transferase SufE PF02657.15 AFZ79207.1 - 9.5e-11 41.6 0.0 1.7e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 Fe-S metabolism associated domain ThiI PF02568.14 AFZ79207.1 - 1.4e-07 31.4 0.1 4.8e-07 29.6 0.0 1.9 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) QueC PF06508.13 AFZ79207.1 - 0.0006 19.4 0.0 0.001 18.6 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC NAD_synthase PF02540.17 AFZ79207.1 - 0.0043 16.2 0.0 0.016 14.4 0.0 1.8 2 0 0 2 2 2 1 NAD synthase Asn_synthase PF00733.21 AFZ79207.1 - 0.013 15.1 0.0 0.021 14.5 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase LSM PF01423.22 AFZ79207.1 - 0.058 13.1 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 LSM domain Torsin PF06309.11 AFZ79208.1 - 0.018 15.1 0.0 0.032 14.3 0.0 1.4 1 0 0 1 1 1 0 Torsin ODV-E18 PF10717.9 AFZ79208.1 - 0.052 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Peptidase_C1 PF00112.23 AFZ79209.1 - 3.9e-49 167.7 6.4 7.4e-49 166.8 6.4 1.4 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 AFZ79209.1 - 5.3e-05 23.6 0.1 0.00012 22.4 0.1 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 AFZ79209.1 - 0.00031 19.6 0.2 0.00054 18.9 0.2 1.3 1 0 0 1 1 1 1 Peptidase C1-like family Merozoite_SPAM PF07133.11 AFZ79209.1 - 0.49 10.4 8.7 0.82 9.6 8.7 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Helicase_C_2 PF13307.6 AFZ79211.1 - 6e-35 120.9 0.0 1.3e-34 119.8 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 AFZ79211.1 - 2.6e-18 66.2 7.5 3.7e-07 29.9 0.1 3.6 3 0 0 3 3 3 3 DEAD_2 DEAD PF00270.29 AFZ79211.1 - 2.5e-05 24.1 0.1 8.8e-05 22.3 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 AFZ79211.1 - 0.00034 20.6 0.2 0.0063 16.5 0.0 2.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 AFZ79211.1 - 0.067 12.7 1.1 1.8 8.0 0.0 2.6 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain DnaJ PF00226.31 AFZ79213.1 - 3.3e-07 30.3 1.1 7.1e-07 29.3 0.4 1.9 2 0 0 2 2 2 1 DnaJ domain Sec34 PF04136.15 AFZ79213.1 - 0.004 17.0 3.5 0.011 15.7 3.5 1.8 1 1 0 1 1 1 1 Sec34-like family NAD_binding_9 PF13454.6 AFZ79213.1 - 0.037 14.0 0.0 0.056 13.4 0.0 1.2 1 0 0 1 1 1 0 FAD-NAD(P)-binding FAINT PF04385.15 AFZ79214.1 - 8.7e-38 128.3 2.8 9.9e-12 44.8 0.8 4.5 4 0 0 4 4 4 4 Domain of unknown function, DUF529 Crystall_3 PF08964.10 AFZ79216.1 - 0.079 13.1 1.6 1.7 8.9 0.0 3.2 3 0 0 3 3 3 0 Beta/Gamma crystallin Proteasom_Rpn13 PF04683.13 AFZ79217.1 - 3.6e-20 72.3 0.0 5.3e-20 71.7 0.0 1.2 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor UCH PF00443.29 AFZ79218.1 - 9.1e-37 126.9 3.2 9.1e-37 126.9 3.2 2.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AFZ79218.1 - 1.8e-22 80.4 2.6 1.8e-22 80.4 2.6 2.6 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 AFZ79218.1 - 0.0093 15.5 1.1 0.023 14.2 0.2 2.2 2 0 0 2 2 2 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase NUMOD3 PF07460.11 AFZ79219.1 - 0.08 13.2 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 NUMOD3 motif (2 copies) LPD28 PF18843.1 AFZ79219.1 - 0.082 12.5 0.0 0.1 12.2 0.0 1.1 1 0 0 1 1 1 0 Large polyvalent protein associated domain 28 MRP_L53 PF10780.9 AFZ79219.1 - 0.18 12.0 0.0 0.29 11.4 0.0 1.3 1 0 0 1 1 1 0 39S ribosomal protein L53/MRP-L53 RNA_pol_Rbc25 PF08292.12 AFZ79220.1 - 5.1e-14 52.6 0.0 7.2e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 AFZ79220.1 - 3.9e-10 40.0 0.1 8.2e-10 38.9 0.0 1.6 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 AFZ79220.1 - 0.079 13.3 0.1 0.73 10.2 0.0 2.2 2 1 0 2 2 2 0 S1 RNA binding domain Nop53 PF07767.11 AFZ79222.1 - 1.2e-24 87.5 18.6 2.8e-24 86.3 18.6 1.5 1 1 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) Pannexin_like PF12534.8 AFZ79222.1 - 0.92 8.5 13.1 0.37 9.8 6.8 2.1 2 0 0 2 2 2 0 Pannexin-like TM region of LRRC8 Ribosomal_S9 PF00380.19 AFZ79224.1 - 2.4e-28 99.1 0.1 4.3e-28 98.3 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S9/S16 DUF1980 PF09323.10 AFZ79224.1 - 0.14 12.1 0.0 0.34 10.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) zf-CCHC_2 PF13696.6 AFZ79226.1 - 9.2e-07 28.6 6.1 9.2e-07 28.6 6.1 2.3 2 0 0 2 2 2 1 Zinc knuckle zf-RING_UBOX PF13445.6 AFZ79226.1 - 3.6e-05 23.7 10.2 0.00011 22.2 10.2 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 AFZ79226.1 - 5.4e-05 23.3 14.2 5.4e-05 23.3 14.2 1.9 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 AFZ79226.1 - 0.0034 17.7 12.7 0.0034 17.7 12.7 2.1 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 AFZ79226.1 - 0.0044 17.0 14.5 0.0044 17.0 14.5 2.1 2 0 0 2 2 2 1 zinc-RING finger domain PNISR PF15996.5 AFZ79226.1 - 0.0084 16.4 4.8 0.0084 16.4 4.8 2.2 2 0 0 2 2 2 1 Arginine/serine-rich protein PNISR zf-C3HC4_2 PF13923.6 AFZ79226.1 - 0.0097 15.7 14.9 0.0097 15.7 14.9 2.2 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DWNN PF08783.11 AFZ79226.1 - 0.01 16.1 0.0 0.034 14.4 0.0 1.9 1 0 0 1 1 1 0 DWNN domain zf-C3HC4 PF00097.25 AFZ79226.1 - 0.016 15.1 14.6 0.016 15.1 14.6 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf_UBZ PF18439.1 AFZ79226.1 - 0.084 12.5 2.3 0.11 12.1 0.2 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-CCHC PF00098.23 AFZ79226.1 - 0.28 11.4 5.3 0.91 9.7 5.3 1.9 1 0 0 1 1 1 0 Zinc knuckle Astro_capsid_p PF12226.8 AFZ79226.1 - 0.46 9.6 6.2 0.78 8.8 6.2 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein PTPlike_phytase PF14566.6 AFZ79226.1 - 0.55 10.3 3.6 1.4 9.0 3.6 1.7 1 0 0 1 1 1 0 Inositol hexakisphosphate GEN1_C PF18380.1 AFZ79226.1 - 0.91 10.5 8.3 0.25 12.3 2.4 2.2 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain DUF4611 PF15387.6 AFZ79226.1 - 1.1 9.5 11.4 0.28 11.4 7.9 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) zf-C3HC4_3 PF13920.6 AFZ79226.1 - 3.9 7.4 17.7 0.26 11.2 11.1 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Metallophos PF00149.28 AFZ79229.1 - 1.6e-38 133.3 0.1 2e-38 133.0 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 AFZ79229.1 - 2.8e-20 72.5 2.7 2.8e-20 72.5 2.7 1.8 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain ABC1 PF03109.16 AFZ79230.1 - 2.5e-25 89.0 0.0 5.5e-25 87.8 0.0 1.6 1 0 0 1 1 1 1 ABC1 family Beta-lactamase PF00144.24 AFZ79230.1 - 3.9e-21 75.6 0.0 5.5e-18 65.3 0.0 2.2 2 0 0 2 2 2 2 Beta-lactamase DUF2465 PF10239.9 AFZ79230.1 - 0.13 11.5 0.2 0.24 10.6 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2465) mRNA_cap_enzyme PF01331.19 AFZ79231.1 - 4.7e-40 137.5 0.0 7.2e-40 136.9 0.0 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 AFZ79231.1 - 1.5e-16 60.9 0.1 7.9e-16 58.6 0.1 2.1 1 1 0 1 1 1 1 mRNA capping enzyme, C-terminal domain Thioredoxin PF00085.20 AFZ79232.1 - 1.2e-06 28.4 0.3 6.3e-05 22.9 0.0 3.1 3 1 0 3 3 3 1 Thioredoxin Thioredoxin_8 PF13905.6 AFZ79232.1 - 0.00015 22.0 1.3 0.025 14.9 0.2 3.3 2 1 1 3 3 3 1 Thioredoxin-like OST3_OST6 PF04756.13 AFZ79232.1 - 0.00087 18.7 2.4 0.0032 16.9 0.1 2.6 2 1 1 3 3 3 1 OST3 / OST6 family, transporter family TrbC_Ftype PF09673.10 AFZ79232.1 - 0.0034 17.4 0.0 0.0088 16.1 0.0 1.6 1 0 0 1 1 1 1 Type-F conjugative transfer system pilin assembly protein Thioredoxin_2 PF13098.6 AFZ79232.1 - 0.066 13.7 0.0 2 8.9 0.0 2.6 2 1 0 2 2 2 0 Thioredoxin-like domain Abhydrolase_3 PF07859.13 AFZ79233.1 - 0.0004 20.3 0.0 0.00052 19.9 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Pro-rich_19 PF15455.6 AFZ79234.1 - 0.11 11.6 0.5 0.16 11.0 0.5 1.2 1 0 0 1 1 1 0 Proline-rich 19 LIP PF03583.14 AFZ79235.1 - 4.4e-05 23.0 0.6 0.00013 21.4 0.0 1.8 2 0 0 2 2 2 1 Secretory lipase Abhydrolase_2 PF02230.16 AFZ79235.1 - 0.00012 22.0 0.8 0.0029 17.4 0.1 2.1 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 AFZ79235.1 - 0.0084 15.4 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 AFZ79235.1 - 0.064 12.7 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family FSH1 PF03959.13 AFZ79235.1 - 0.075 12.7 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Serine hydrolase (FSH1) YfhE PF14152.6 AFZ79235.1 - 2.7 8.1 4.8 0.41 10.8 0.7 1.7 2 0 0 2 2 2 0 YfhE-like protein FAINT PF04385.15 AFZ79236.1 - 3.4e-44 148.8 42.5 4.5e-07 29.8 0.1 9.7 9 0 0 9 9 9 9 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79239.1 - 3.5e-25 87.9 24.6 9.4e-07 28.8 1.9 6.7 5 1 1 6 6 6 4 Domain of unknown function, DUF529 DUF3965 PF13112.6 AFZ79239.1 - 0.099 11.8 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3965) Pam16 PF03656.13 AFZ79242.1 - 1.1e-10 41.7 0.0 1.2e-10 41.5 0.0 1.1 1 0 0 1 1 1 1 Pam16 DnaJ PF00226.31 AFZ79242.1 - 1.8e-08 34.4 0.0 2.6e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain eRF1_1 PF03463.15 AFZ79243.1 - 4.5e-28 97.8 0.0 8.9e-28 96.9 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_3 PF03465.15 AFZ79243.1 - 1.3e-15 57.9 0.2 2.7e-15 56.8 0.2 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_2 PF03464.15 AFZ79243.1 - 1.8e-14 54.2 0.1 3e-14 53.5 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 RRP7 PF12923.7 AFZ79244.1 - 3.2e-08 33.7 0.4 6.7e-08 32.7 0.4 1.5 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain DUF5093 PF17011.5 AFZ79244.1 - 0.082 13.2 0.4 0.18 12.1 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5093) PCI PF01399.27 AFZ79245.1 - 2.3e-08 34.5 0.0 5.3e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 PCI domain DUF5598 PF18127.1 AFZ79245.1 - 0.054 13.9 0.1 0.13 12.7 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5598) RNA_pol_Rpb4 PF03874.16 AFZ79246.1 - 9.9e-14 51.7 0.3 1.4e-13 51.2 0.3 1.3 1 1 0 1 1 1 1 RNA polymerase Rpb4 Cytokin_check_N PF10407.9 AFZ79246.1 - 0.082 12.9 0.1 0.22 11.5 0.1 1.8 1 0 0 1 1 1 0 Cdc14 phosphatase binding protein N-terminus Nucleoporin_FG PF13634.6 AFZ79247.1 - 5.9e-37 126.4 200.7 5.9e-11 43.1 27.6 5.9 1 1 5 6 6 6 6 Nucleoporin FG repeat region Nsp1_C PF05064.13 AFZ79247.1 - 2.4e-11 43.5 5.5 7.3e-11 41.9 5.5 1.7 1 0 0 1 1 1 1 Nsp1-like C-terminal region Med4 PF10018.9 AFZ79247.1 - 0.0057 16.3 1.1 0.0057 16.3 1.1 2.6 1 1 1 2 2 2 1 Vitamin-D-receptor interacting Mediator subunit 4 HEPN_Toprim_N PF18871.1 AFZ79247.1 - 0.0091 15.9 1.3 0.014 15.4 1.3 1.2 1 0 0 1 1 1 1 HEPN/Toprim N-terminal domain 1 Polbeta PF18765.1 AFZ79247.1 - 0.01 15.9 0.1 0.072 13.2 0.1 2.6 1 1 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase APG17 PF04108.12 AFZ79247.1 - 0.012 14.7 6.4 0.012 14.8 5.0 1.6 1 1 0 1 1 1 0 Autophagy protein Apg17 NTP_transf_2 PF01909.23 AFZ79247.1 - 0.025 14.9 0.0 0.071 13.4 0.0 1.8 1 0 0 1 1 1 0 Nucleotidyltransferase domain DUF745 PF05335.13 AFZ79247.1 - 0.035 13.8 3.9 0.06 13.1 3.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Desmo_N PF06771.11 AFZ79247.1 - 0.044 14.1 2.1 0.31 11.4 0.2 2.7 1 1 0 2 2 2 0 Viral Desmoplakin N-terminus Serine_rich PF08824.10 AFZ79247.1 - 0.046 13.7 0.4 0.046 13.7 0.4 1.8 2 0 0 2 2 2 0 Serine rich protein interaction domain FapA PF03961.13 AFZ79247.1 - 0.087 11.4 5.7 0.15 10.7 5.7 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A ArAE_2_N PF10337.9 AFZ79247.1 - 0.11 11.5 1.2 0.16 10.9 1.2 1.1 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal TMPIT PF07851.13 AFZ79247.1 - 0.21 10.8 3.5 0.38 9.9 3.5 1.3 1 0 0 1 1 1 0 TMPIT-like protein Tropomyosin_1 PF12718.7 AFZ79247.1 - 0.34 11.1 10.3 0.2 11.8 7.7 1.9 1 1 0 1 1 1 0 Tropomyosin like Ion_trans_N PF08412.10 AFZ79247.1 - 0.34 10.5 1.2 14 5.4 0.0 4.1 5 0 0 5 5 4 0 Ion transport protein N-terminal DUF16 PF01519.16 AFZ79247.1 - 0.43 11.1 7.2 1.3 9.5 7.1 1.9 1 1 0 1 1 1 0 Protein of unknown function DUF16 Laminin_II PF06009.12 AFZ79247.1 - 0.52 10.3 5.8 1.3 9.1 3.9 2.2 1 1 1 2 2 2 0 Laminin Domain II LOH1CR12 PF10158.9 AFZ79247.1 - 0.66 10.0 4.0 0.87 9.6 1.0 2.2 1 1 1 2 2 2 0 Tumour suppressor protein DUF4164 PF13747.6 AFZ79247.1 - 3.3 8.0 5.4 1.9 8.8 0.4 2.7 2 1 2 4 4 4 0 Domain of unknown function (DUF4164) CLZ PF16526.5 AFZ79247.1 - 5.7 7.4 9.7 1.1 9.6 4.0 2.7 3 1 1 4 4 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Fib_alpha PF08702.10 AFZ79247.1 - 6.7 6.9 11.0 20 5.3 7.0 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Lon_C PF05362.13 AFZ79248.1 - 5.9e-62 208.9 2.2 3.8e-53 180.1 0.1 2.7 3 0 0 3 3 3 2 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 AFZ79248.1 - 2.6e-29 102.6 0.0 5.1e-29 101.6 0.0 1.5 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 AFZ79248.1 - 4.2e-20 72.5 0.0 2.2e-19 70.2 0.0 2.2 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) ChlI PF13541.6 AFZ79248.1 - 2.5e-06 27.3 0.0 5.3e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.14 AFZ79248.1 - 2.9e-06 27.3 0.0 6.8e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 AFZ79248.1 - 6.2e-05 22.4 0.1 0.00028 20.2 0.0 2.0 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_16 PF13191.6 AFZ79248.1 - 7.2e-05 23.2 0.1 0.00051 20.5 0.0 2.2 2 1 0 2 2 1 1 AAA ATPase domain IstB_IS21 PF01695.17 AFZ79248.1 - 0.00014 21.6 0.0 0.00035 20.4 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_2 PF07724.14 AFZ79248.1 - 0.00034 20.8 0.0 0.0013 18.8 0.0 2.0 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 AFZ79248.1 - 0.00049 20.4 0.1 0.023 15.0 0.1 2.8 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AFZ79248.1 - 0.0012 19.4 1.5 0.0076 16.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 AFZ79248.1 - 0.002 17.9 0.0 0.0055 16.5 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_PrkA PF08298.11 AFZ79248.1 - 0.0038 16.2 0.0 0.0069 15.3 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain AAA_25 PF13481.6 AFZ79248.1 - 0.022 14.3 1.2 0.16 11.5 0.1 2.4 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 AFZ79248.1 - 0.027 14.4 0.0 0.11 12.4 0.0 2.1 2 0 0 2 2 2 0 NTPase AAA_3 PF07726.11 AFZ79248.1 - 0.028 14.3 0.0 0.065 13.1 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 AFZ79248.1 - 0.03 14.4 0.2 0.25 11.4 0.0 2.7 3 0 0 3 3 2 0 AAA domain AAA_24 PF13479.6 AFZ79248.1 - 0.036 13.8 0.4 0.38 10.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain ArsA_ATPase PF02374.15 AFZ79248.1 - 0.049 12.8 1.9 1.6 7.9 0.0 2.3 2 0 0 2 2 2 0 Anion-transporting ATPase DnaB_C PF03796.15 AFZ79248.1 - 0.051 12.9 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain RNA_helicase PF00910.22 AFZ79248.1 - 0.063 13.7 0.0 0.22 11.9 0.0 2.0 1 0 0 1 1 1 0 RNA helicase APS_kinase PF01583.20 AFZ79248.1 - 0.084 12.8 0.2 0.36 10.7 0.0 2.0 2 0 0 2 2 2 0 Adenylylsulphate kinase RsgA_GTPase PF03193.16 AFZ79248.1 - 0.37 10.7 0.0 0.37 10.7 0.0 2.8 3 0 0 3 3 2 0 RsgA GTPase TRAP_alpha PF03896.16 AFZ79248.1 - 1.4 8.0 5.0 7.5 5.7 0.4 2.5 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit LSM PF01423.22 AFZ79249.1 - 1.1e-20 73.1 0.1 1.3e-20 72.8 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 AFZ79249.1 - 0.021 14.9 0.0 0.028 14.5 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain DUF150_C PF17384.2 AFZ79249.1 - 0.17 12.1 0.1 0.24 11.5 0.1 1.3 1 0 0 1 1 1 0 RimP C-terminal SH3 domain CBM_6 PF03422.15 AFZ79250.1 - 0.26 11.6 0.1 0.26 11.6 0.1 2.3 2 0 0 2 2 2 0 Carbohydrate binding module (family 6) FAINT PF04385.15 AFZ79251.1 - 1.1e-07 31.7 0.2 0.0019 18.2 0.1 3.4 3 0 0 3 3 3 2 Domain of unknown function, DUF529 Frataxin_Cyay PF01491.16 AFZ79251.1 - 0.0087 16.1 0.5 0.065 13.3 0.0 2.5 3 0 0 3 3 3 1 Frataxin-like domain SET PF00856.28 AFZ79253.1 - 2e-21 77.1 0.3 9.2e-21 75.0 0.1 2.3 2 0 0 2 2 2 1 SET domain TRAPP PF04051.16 AFZ79253.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Transport protein particle (TRAPP) component SRP1_TIP1 PF00660.17 AFZ79254.1 - 0.087 12.9 0.1 0.24 11.5 0.1 1.8 1 1 0 1 1 1 0 Seripauperin and TIP1 family Spectrin PF00435.21 AFZ79254.1 - 0.12 12.9 0.4 0.23 12.0 0.4 1.6 1 0 0 1 1 1 0 Spectrin repeat Pox_A_type_inc PF04508.12 AFZ79255.1 - 0.026 14.4 0.3 0.089 12.7 0.3 1.9 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Diphthamide_syn PF01866.17 AFZ79256.1 - 3.3e-99 332.1 0.0 4.9e-99 331.6 0.0 1.2 1 0 0 1 1 1 1 Putative diphthamide synthesis protein YTH PF04146.15 AFZ79257.1 - 1.6e-15 57.4 0.1 3.5e-14 53.1 0.1 2.2 1 1 0 1 1 1 1 YT521-B-like domain PWI PF01480.17 AFZ79258.1 - 3.8e-29 100.8 0.0 5.6e-29 100.3 0.0 1.3 1 0 0 1 1 1 1 PWI domain DcpS_C PF11969.8 AFZ79259.1 - 4.2e-05 24.0 0.3 0.00039 20.9 0.3 2.2 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DUF35_N PF12172.8 AFZ79259.1 - 0.0029 17.4 0.1 0.006 16.4 0.1 1.5 1 0 0 1 1 1 1 Rubredoxin-like zinc ribbon domain (DUF35_N) DZR PF12773.7 AFZ79259.1 - 0.061 13.3 0.6 0.11 12.6 0.6 1.4 1 0 0 1 1 1 0 Double zinc ribbon Ribosomal_L9_N PF01281.19 AFZ79260.1 - 8.7e-12 44.4 0.0 1.4e-11 43.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain Ribosomal_L9_C PF03948.14 AFZ79260.1 - 0.00044 20.6 0.2 0.001 19.5 0.2 1.7 1 1 0 1 1 1 1 Ribosomal protein L9, C-terminal domain Rad52_Rad22 PF04098.15 AFZ79260.1 - 0.0071 16.3 0.1 0.013 15.4 0.1 1.4 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein IBN_N PF03810.19 AFZ79260.1 - 0.089 12.7 0.1 0.46 10.4 0.1 1.9 2 0 0 2 2 2 0 Importin-beta N-terminal domain DSPc PF00782.20 AFZ79261.1 - 6.1e-17 61.7 0.0 9.8e-17 61.0 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 AFZ79261.1 - 0.0079 15.8 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase N2227 PF07942.12 AFZ79262.1 - 4.2e-91 304.9 0.0 5.7e-91 304.5 0.0 1.2 1 0 0 1 1 1 1 N2227-like protein Methyltransf_11 PF08241.12 AFZ79262.1 - 0.0096 16.5 0.0 0.038 14.6 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 AFZ79262.1 - 0.11 13.3 0.0 0.66 10.8 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_23 PF13489.6 AFZ79262.1 - 0.16 11.8 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain DFP PF04127.15 AFZ79263.1 - 1.8e-08 34.5 0.3 2.6e-08 33.9 0.3 1.2 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein CREPT PF16566.5 AFZ79263.1 - 0.026 14.7 0.1 0.11 12.7 0.0 1.9 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Jun PF03957.13 AFZ79263.1 - 0.15 11.9 0.1 0.67 9.8 0.1 1.9 1 1 0 1 1 1 0 Jun-like transcription factor Ribosomal_60s PF00428.19 AFZ79264.1 - 7.8e-23 80.9 8.9 9e-23 80.7 8.9 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein Jag_N PF14804.6 AFZ79264.1 - 0.045 14.1 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 Jag N-terminus UMP1 PF05348.11 AFZ79265.1 - 8.3e-14 51.8 0.0 1e-13 51.6 0.0 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 Torus PF16131.5 AFZ79266.1 - 9.4e-06 26.3 4.8 1e-05 26.2 0.2 2.2 1 1 1 2 2 2 1 Torus domain zf_CCCH_4 PF18345.1 AFZ79266.1 - 1.8e-05 24.6 3.0 1.8e-05 24.6 3.0 1.7 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH_4 PF18044.1 AFZ79266.1 - 0.0011 18.7 0.9 0.0011 18.7 0.9 2.5 2 1 0 2 2 2 1 CCCH-type zinc finger zf-NPL4 PF05020.15 AFZ79266.1 - 0.013 15.6 0.7 2 8.5 0.1 2.1 2 0 0 2 2 2 0 NPL4 family, putative zinc binding region UDG PF03167.19 AFZ79267.1 - 1.8e-20 73.5 0.0 2.9e-20 72.8 0.0 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily RRM_1 PF00076.22 AFZ79268.1 - 3e-37 126.3 0.2 2.5e-19 68.8 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AFZ79268.1 - 0.0007 19.7 0.1 0.2 11.8 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif RRM_5 PF13893.6 AFZ79268.1 - 0.0012 18.4 0.0 0.6 9.7 0.0 2.3 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.11 AFZ79268.1 - 0.0022 17.6 0.3 0.17 11.6 0.1 2.4 2 0 0 2 2 2 1 Ribonuclease B OB domain PHM7_cyt PF14703.6 AFZ79268.1 - 0.013 15.7 0.0 0.19 11.9 0.0 2.1 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Cas_Cas2CT1978 PF09707.10 AFZ79268.1 - 0.075 13.1 0.0 3.3 7.8 0.0 2.3 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) Podoplanin PF05808.11 AFZ79269.1 - 2.6 8.2 7.2 4.5 7.3 7.2 1.3 1 0 0 1 1 1 0 Podoplanin PCI PF01399.27 AFZ79270.1 - 1.1e-13 51.5 2.2 2.6e-13 50.4 0.6 2.4 2 0 0 2 2 2 1 PCI domain eIF3_N PF09440.10 AFZ79270.1 - 0.0071 16.8 0.0 0.027 14.9 0.0 2.1 1 1 0 1 1 1 1 eIF3 subunit 6 N terminal domain Surfac_D-trimer PF09006.11 AFZ79270.1 - 0.13 12.2 0.1 0.31 11.0 0.1 1.5 1 0 0 1 1 1 0 Lung surfactant protein D coiled-coil trimerisation RRM_1 PF00076.22 AFZ79271.1 - 3e-23 81.4 0.1 1.2e-11 44.3 0.0 2.5 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 AFZ79271.1 - 3.3e-09 36.4 0.0 2.2e-05 24.0 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AFZ79271.1 - 0.0047 16.8 0.0 1.1 9.2 0.0 2.3 2 0 0 2 2 2 2 Occluded RNA-recognition motif PHM7_cyt PF14703.6 AFZ79271.1 - 0.029 14.6 0.1 13 6.0 0.0 3.0 2 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter Pkinase PF00069.25 AFZ79272.1 - 1e-60 205.4 0.0 1.3e-60 205.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ79272.1 - 6.1e-35 120.7 0.0 7.7e-35 120.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AFZ79272.1 - 0.0006 19.2 0.0 0.00095 18.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like EF-hand_7 PF13499.6 AFZ79273.1 - 8.7e-05 22.9 0.1 0.23 11.9 0.0 3.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 AFZ79273.1 - 0.0084 16.0 0.1 0.84 9.7 0.0 3.5 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.6 AFZ79273.1 - 0.085 12.7 0.2 29 4.6 0.1 3.1 2 0 0 2 2 2 0 EF-hand domain pair TruB_N PF01509.18 AFZ79274.1 - 5.6e-43 146.9 0.0 7.6e-43 146.4 0.0 1.1 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) Tudor_FRX1 PF18336.1 AFZ79274.1 - 0.16 11.9 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 Fragile X mental retardation Tudor domain PI31_Prot_C PF08577.11 AFZ79275.1 - 0.0027 18.8 0.3 0.0027 18.8 0.3 2.1 1 1 1 2 2 2 1 PI31 proteasome regulator Ion_trans PF00520.31 AFZ79276.1 - 1.4e-11 44.1 35.8 2e-11 43.6 35.8 1.2 1 0 0 1 1 1 1 Ion transport protein LSM14 PF12701.7 AFZ79277.1 - 2.4e-26 91.6 0.0 3.1e-25 88.1 0.0 2.2 2 0 0 2 2 2 1 Scd6-like Sm domain SM-ATX PF14438.6 AFZ79277.1 - 4.4e-08 33.2 0.0 8.9e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Ataxin 2 SM domain Apc15p PF05841.11 AFZ79277.1 - 0.55 11.0 4.6 3.4 8.5 0.0 2.9 2 1 1 3 3 3 0 Apc15p protein ANAPC4_WD40 PF12894.7 AFZ79278.1 - 4e-11 43.1 1.6 0.00065 19.9 0.1 5.0 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AFZ79278.1 - 1.1e-06 29.2 12.1 0.026 15.4 0.3 6.9 6 1 0 6 6 6 2 WD domain, G-beta repeat PD40 PF07676.12 AFZ79278.1 - 0.074 13.0 4.6 6.3 6.9 0.0 4.3 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat YCII PF03795.14 AFZ79279.1 - 0.00099 19.5 0.0 2.6 8.5 0.0 2.5 2 0 0 2 2 2 2 YCII-related domain Spo7 PF03907.13 AFZ79279.1 - 0.047 13.2 0.1 0.14 11.6 0.1 1.8 1 0 0 1 1 1 0 Spo7-like protein ABC_tran PF00005.27 AFZ79281.1 - 4.4e-31 108.2 0.0 2.3e-16 60.6 0.0 2.8 2 1 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 AFZ79281.1 - 1.8e-07 31.1 21.3 1.8e-07 31.1 21.3 3.2 3 1 0 3 3 2 1 ABC transporter transmembrane region AAA_21 PF13304.6 AFZ79281.1 - 1.7e-05 24.8 2.0 0.15 11.9 0.1 3.5 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 AFZ79281.1 - 6.6e-05 23.3 0.1 0.075 13.4 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.6 AFZ79281.1 - 7.3e-05 22.6 0.2 0.046 13.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 AFZ79281.1 - 0.00016 21.6 0.6 0.21 11.5 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_18 PF13238.6 AFZ79281.1 - 0.00049 20.6 0.1 0.93 10.0 0.1 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 AFZ79281.1 - 0.00075 19.8 0.2 0.55 10.5 0.0 2.9 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 AFZ79281.1 - 0.0013 17.8 0.5 1.3 8.0 0.2 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_29 PF13555.6 AFZ79281.1 - 0.0015 18.2 3.4 0.82 9.5 0.2 2.8 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 AFZ79281.1 - 0.0019 18.8 9.4 0.06 13.9 1.5 3.3 3 0 0 3 3 3 2 AAA domain Zeta_toxin PF06414.12 AFZ79281.1 - 0.002 17.4 0.4 0.98 8.7 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin DnaB_C PF03796.15 AFZ79281.1 - 0.005 16.2 0.1 1.3 8.3 0.0 2.6 3 0 0 3 3 3 1 DnaB-like helicase C terminal domain NACHT PF05729.12 AFZ79281.1 - 0.0051 16.7 1.5 4.1 7.3 0.1 3.1 3 0 0 3 3 3 2 NACHT domain cobW PF02492.19 AFZ79281.1 - 0.0067 16.0 4.9 0.66 9.5 0.1 3.3 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.17 AFZ79281.1 - 0.012 15.8 2.2 0.29 11.2 0.1 2.7 2 0 0 2 2 2 0 Helicase HerA, central domain SMC_N PF02463.19 AFZ79281.1 - 0.015 14.8 1.4 0.2 11.1 0.1 2.6 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain FtsK_SpoIIIE PF01580.18 AFZ79281.1 - 0.02 14.2 0.3 1.3 8.3 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family TsaE PF02367.17 AFZ79281.1 - 0.025 14.6 1.1 6.4 6.8 0.1 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATP_bind_1 PF03029.17 AFZ79281.1 - 0.031 14.1 0.2 6.7 6.4 0.0 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein SbcCD_C PF13558.6 AFZ79281.1 - 0.035 14.3 0.0 0.091 13.0 0.0 1.6 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit MMR_HSR1 PF01926.23 AFZ79281.1 - 0.042 13.9 0.3 0.65 10.1 0.1 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_19 PF13245.6 AFZ79281.1 - 0.048 14.0 1.2 9.1 6.6 0.1 2.6 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 AFZ79281.1 - 0.063 12.9 1.5 0.33 10.6 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_25 PF13481.6 AFZ79281.1 - 0.066 12.8 0.2 2.1 7.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain MobB PF03205.14 AFZ79281.1 - 0.069 13.1 1.2 2.1 8.2 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B NB-ARC PF00931.22 AFZ79281.1 - 0.077 12.2 2.4 0.53 9.4 0.1 2.6 2 0 0 2 2 2 0 NB-ARC domain NTPase_1 PF03266.15 AFZ79281.1 - 0.085 12.8 0.5 12 5.8 0.1 2.5 2 0 0 2 2 2 0 NTPase TrwB_AAD_bind PF10412.9 AFZ79281.1 - 0.09 11.7 0.4 10 4.9 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain MeaB PF03308.16 AFZ79281.1 - 0.19 10.7 1.8 0.19 10.7 0.1 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Surp PF01805.20 AFZ79282.1 - 1.4e-37 127.5 1.1 2.2e-18 66.0 0.1 2.4 2 0 0 2 2 2 2 Surp module PRP21_like_P PF12230.8 AFZ79282.1 - 1.9e-36 126.0 11.4 3.9e-35 121.7 11.4 2.3 1 1 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein MscS_TM PF12794.7 AFZ79282.1 - 0.094 11.6 1.0 0.14 11.0 1.0 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 zf-WRNIP1_ubi PF18279.1 AFZ79282.1 - 0.21 12.3 0.6 0.43 11.3 0.6 1.5 1 0 0 1 1 1 0 Werner helicase-interacting protein 1 ubiquitin-binding domain Ribosomal_L20 PF00453.18 AFZ79286.1 - 1.1e-23 83.4 1.1 1.4e-23 83.0 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L20 Sec62 PF03839.16 AFZ79287.1 - 3.6e-30 105.1 2.3 5.1e-30 104.6 2.3 1.2 1 0 0 1 1 1 1 Translocation protein Sec62 ubiquitin PF00240.23 AFZ79288.1 - 2.3e-05 24.1 0.2 0.14 11.9 0.0 3.1 2 2 0 2 2 2 2 Ubiquitin family Ubiquitin_4 PF18036.1 AFZ79288.1 - 0.0016 18.5 0.7 2.8 8.0 0.0 2.8 3 1 0 3 3 3 2 Ubiquitin-like domain Ndc1_Nup PF09531.10 AFZ79288.1 - 0.18 10.4 0.2 0.23 10.1 0.2 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TRAM_LAG1_CLN8 PF03798.16 AFZ79289.1 - 7.2e-26 91.1 13.2 1.1e-25 90.5 13.2 1.2 1 0 0 1 1 1 1 TLC domain IL4_i_Ig PF18258.1 AFZ79289.1 - 0.05 13.8 0.0 3.6 7.9 0.0 2.4 2 0 0 2 2 2 0 Interleukin-4 inducing immunoglobulin-binding domain Cytochrom_C PF00034.21 AFZ79290.1 - 8.6e-13 49.3 0.0 1.3e-12 48.7 0.0 1.3 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 AFZ79290.1 - 1.7e-07 31.5 0.7 7e-07 29.5 0.7 1.8 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 AFZ79290.1 - 0.0026 17.5 0.0 0.0049 16.6 0.0 1.4 1 0 0 1 1 1 1 Cytochrome c-550 domain DUF1232 PF06803.12 AFZ79290.1 - 0.13 12.0 0.1 0.23 11.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1232) Cytochrome-c551 PF10643.9 AFZ79290.1 - 0.14 11.7 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 Rad4 PF03835.15 AFZ79293.1 - 0.025 14.3 0.1 7.6 6.2 0.0 2.6 1 1 1 2 2 2 0 Rad4 transglutaminase-like domain HOIP-UBA PF16678.5 AFZ79294.1 - 0.031 14.3 0.0 0.072 13.1 0.0 1.6 1 0 0 1 1 1 0 HOIP UBA domain pair Fes1 PF08609.10 AFZ79294.1 - 4.4 8.3 7.1 2.6 9.0 4.2 2.2 2 1 0 2 2 2 0 Nucleotide exchange factor Fes1 Pkinase PF00069.25 AFZ79295.1 - 2.7e-79 266.3 0.0 5.8e-79 265.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ79295.1 - 2.5e-40 138.4 0.0 4.1e-40 137.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.6 AFZ79295.1 - 1.2e-27 96.2 7.2 6.9e-14 52.1 4.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 AFZ79295.1 - 4.2e-26 88.5 11.5 1.3e-06 27.6 0.7 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 AFZ79295.1 - 4.1e-22 76.2 11.5 1.7e-05 24.4 0.8 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 AFZ79295.1 - 5.3e-20 69.9 13.5 2.5e-05 23.6 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 AFZ79295.1 - 3.2e-18 65.3 13.4 5.6e-07 29.3 1.3 4.8 3 2 2 5 5 5 4 EF-hand domain pair EF-hand_9 PF14658.6 AFZ79295.1 - 8.5e-07 29.2 1.9 0.0021 18.3 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_11 PF08976.11 AFZ79295.1 - 0.00038 21.3 0.3 0.53 11.2 0.0 2.7 1 1 1 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 AFZ79295.1 - 0.00039 20.7 0.6 2 8.7 0.0 2.9 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Pkinase_fungal PF17667.1 AFZ79295.1 - 0.00055 18.8 0.1 0.0045 15.8 0.0 2.4 3 0 0 3 3 3 1 Fungal protein kinase APH PF01636.23 AFZ79295.1 - 0.0029 17.6 0.0 0.0057 16.6 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family EF-hand_4 PF12763.7 AFZ79295.1 - 0.0035 17.3 1.0 0.14 12.2 0.3 3.3 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 AFZ79295.1 - 0.0067 16.4 3.1 11 5.9 0.0 3.6 2 1 1 3 3 3 0 Caleosin related protein RIO1 PF01163.22 AFZ79295.1 - 0.017 14.7 0.0 0.032 13.8 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 AFZ79295.1 - 0.04 13.3 0.0 0.076 12.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Dockerin_1 PF00404.18 AFZ79295.1 - 1 9.6 8.0 3.7 7.8 0.5 3.7 2 1 2 4 4 4 0 Dockerin type I domain TFIIIC_sub6 PF10419.9 AFZ79296.1 - 0.0088 15.9 0.1 0.0099 15.7 0.1 1.3 1 1 0 1 1 1 1 TFIIIC subunit triple barrel domain Oxysterol_BP PF01237.18 AFZ79297.1 - 7.5e-124 413.3 0.1 1.1e-123 412.9 0.1 1.2 1 0 0 1 1 1 1 Oxysterol-binding protein PH PF00169.29 AFZ79297.1 - 2.2e-11 44.2 0.2 8.6e-11 42.3 0.1 2.1 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 AFZ79297.1 - 0.18 12.2 1.6 16 6.0 0.6 3.3 2 1 0 2 2 2 0 Pleckstrin homology domain AAA_16 PF13191.6 AFZ79298.1 - 0.0008 19.8 0.0 0.007 16.8 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AFZ79298.1 - 0.0016 18.7 0.1 0.0036 17.6 0.1 1.6 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 AFZ79298.1 - 0.0022 17.9 0.0 0.0044 17.0 0.0 1.6 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea Chitin_synth_1 PF01644.17 AFZ79298.1 - 0.01 15.8 0.0 0.022 14.7 0.0 1.5 1 0 0 1 1 1 0 Chitin synthase AAA PF00004.29 AFZ79298.1 - 0.059 13.8 0.0 0.12 12.8 0.0 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Myb_DNA-binding PF00249.31 AFZ79300.1 - 5.2e-07 29.7 0.4 1.2e-06 28.6 0.4 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AFZ79300.1 - 0.00046 20.4 3.5 0.0016 18.6 0.4 2.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain Aha1_N PF09229.11 AFZ79301.1 - 6e-24 84.8 1.2 6e-24 84.8 1.2 2.6 2 0 0 2 2 2 1 Activator of Hsp90 ATPase, N-terminal TPR_2 PF07719.17 AFZ79301.1 - 4.9e-10 38.7 2.4 1.3e-05 25.0 0.5 4.4 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 AFZ79301.1 - 8e-09 35.9 0.1 2.7e-08 34.2 0.1 1.9 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 AFZ79301.1 - 1.5e-06 27.8 3.1 5.5e-05 22.8 0.7 3.4 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 AFZ79301.1 - 0.00014 21.8 9.6 0.00045 20.2 0.2 4.3 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 AFZ79301.1 - 0.00019 21.6 1.0 0.15 12.5 0.7 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 AFZ79301.1 - 0.00027 21.5 0.0 0.0016 19.1 0.0 2.4 3 0 0 3 3 1 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 AFZ79301.1 - 0.00079 19.4 0.1 0.0061 16.6 0.1 2.4 1 1 1 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 AFZ79301.1 - 0.0029 17.7 0.0 0.0049 17.0 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 AFZ79301.1 - 0.015 15.9 2.2 0.11 13.2 0.1 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 AFZ79301.1 - 0.016 15.8 0.0 0.03 15.0 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 AFZ79301.1 - 0.025 15.1 0.2 0.15 12.5 0.0 2.3 2 1 1 3 3 3 0 Alkyl sulfatase dimerisation ANAPC3 PF12895.7 AFZ79301.1 - 0.025 14.8 1.9 0.073 13.3 0.9 2.0 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 AFZ79301.1 - 0.053 13.8 0.9 33 4.8 0.1 2.7 1 1 1 3 3 3 0 Tetratricopeptide repeat DUF357 PF04010.13 AFZ79301.1 - 0.062 13.4 3.9 8.8 6.5 0.3 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF357) TPR_11 PF13414.6 AFZ79301.1 - 0.084 12.6 0.7 1.9 8.2 0.0 2.7 2 1 1 3 3 3 0 TPR repeat VASt PF16016.5 AFZ79301.1 - 0.31 11.4 7.9 0.12 12.7 4.2 2.2 2 1 0 2 2 2 0 VAD1 Analog of StAR-related lipid transfer domain IQ PF00612.27 AFZ79302.1 - 5e-20 69.4 33.3 2.1e-06 27.0 0.1 7.6 7 0 0 7 7 7 7 IQ calmodulin-binding motif RCC1 PF00415.18 AFZ79302.1 - 3.3e-17 62.8 0.1 3.4e-08 34.0 0.0 2.9 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 AFZ79302.1 - 1.5e-12 47.0 11.4 1.2e-08 34.5 0.6 4.0 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat CwfJ_C_2 PF04676.14 AFZ79303.1 - 2.6e-16 60.3 0.0 4.9e-16 59.4 0.0 1.5 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 CwfJ_C_1 PF04677.15 AFZ79303.1 - 6.6e-15 55.0 1.5 1.3e-14 54.1 1.5 1.6 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 Ribo_biogen_C PF04034.13 AFZ79304.1 - 6.3e-46 155.2 0.0 9e-46 154.7 0.0 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 AFZ79304.1 - 7.5e-12 44.9 0.0 1.1e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI WD40 PF00400.32 AFZ79305.1 - 4.6e-29 100.0 14.8 7.9e-07 29.7 1.0 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AFZ79305.1 - 0.00014 22.1 0.4 3.1 8.2 0.0 4.4 4 1 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AFZ79305.1 - 0.001 19.0 0.4 0.15 11.9 0.1 3.1 2 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.6 AFZ79305.1 - 0.055 13.0 0.0 0.21 11.1 0.0 2.1 1 1 0 1 1 1 0 PQQ-like domain Nic96 PF04097.14 AFZ79306.1 - 0.016 13.7 0.2 0.026 13.0 0.2 1.4 1 0 0 1 1 1 0 Nup93/Nic96 TaqI_C PF12950.7 AFZ79306.1 - 2.7 8.1 7.2 8.7 6.4 0.9 3.4 3 0 0 3 3 3 0 TaqI-like C-terminal specificity domain Carb_anhydrase PF00194.21 AFZ79307.1 - 1.1e-20 74.3 10.5 2.3e-16 60.1 0.1 3.7 3 1 0 3 3 3 2 Eukaryotic-type carbonic anhydrase CTNNBL PF08216.11 AFZ79308.1 - 8.3e-27 93.4 0.4 2.9e-26 91.7 0.4 2.0 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear DUF1840 PF08895.11 AFZ79308.1 - 0.056 13.8 0.3 0.21 11.9 0.0 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1840) Erf4 PF10256.9 AFZ79308.1 - 8.7 6.5 7.2 20 5.3 0.0 3.7 4 0 0 4 4 4 0 Golgin subfamily A member 7/ERF4 family DnaJ PF00226.31 AFZ79309.1 - 1.4e-08 34.7 0.0 5.7e-08 32.8 0.0 2.1 2 0 0 2 2 2 1 DnaJ domain TPR_1 PF00515.28 AFZ79309.1 - 2.3e-08 33.5 10.6 0.00041 20.0 2.3 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 AFZ79309.1 - 3.6e-07 29.8 10.9 0.0013 18.7 1.5 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 AFZ79309.1 - 0.00035 20.8 2.1 0.52 10.6 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat Golgin_A5 PF09787.9 AFZ79309.1 - 0.001 18.6 2.6 0.0024 17.4 2.6 1.5 1 0 0 1 1 1 1 Golgin subfamily A member 5 Not3 PF04065.15 AFZ79309.1 - 0.0055 16.2 1.9 0.019 14.4 1.9 1.9 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component TPR_11 PF13414.6 AFZ79309.1 - 0.014 15.0 2.1 0.014 15.0 2.1 2.3 2 0 0 2 2 2 0 TPR repeat TPR_MLP1_2 PF07926.12 AFZ79309.1 - 0.021 14.9 2.8 0.069 13.2 2.8 1.8 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.9 AFZ79309.1 - 0.025 14.6 4.4 0.024 14.6 2.4 2.0 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF5082 PF16888.5 AFZ79309.1 - 0.068 13.4 1.2 0.24 11.7 1.2 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) TPR_16 PF13432.6 AFZ79309.1 - 0.075 13.7 0.1 0.56 10.9 0.1 2.1 1 1 0 1 1 1 0 Tetratricopeptide repeat PSI_integrin PF17205.3 AFZ79309.1 - 0.1 12.4 0.1 0.4 10.5 0.1 2.0 1 0 0 1 1 1 0 Integrin plexin domain TPR_6 PF13174.6 AFZ79309.1 - 0.13 12.9 0.8 1.9 9.3 0.2 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 AFZ79309.1 - 0.16 12.1 8.2 0.59 10.3 0.2 3.5 4 0 0 4 4 3 0 Tetratricopeptide repeat Jnk-SapK_ap_N PF09744.9 AFZ79309.1 - 0.16 12.2 2.3 0.53 10.5 2.3 1.9 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 TPR_8 PF13181.6 AFZ79309.1 - 0.2 12.0 8.7 1 9.8 1.7 3.8 3 1 1 4 4 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 AFZ79309.1 - 1.6 8.8 5.5 0.42 10.7 1.1 2.3 2 0 0 2 2 1 0 Tetratricopeptide repeat MIT PF04212.18 AFZ79309.1 - 2.2 8.4 8.5 0.25 11.4 0.4 3.2 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.6 AFZ79309.1 - 5.4 7.2 8.7 17 5.6 1.0 3.2 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat DUF1508 PF07411.12 AFZ79311.1 - 0.19 11.6 0.1 0.42 10.5 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1508) Clat_adaptor_s PF01217.20 AFZ79312.1 - 8.8e-36 123.0 3.9 9.6e-36 122.8 3.9 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain CAMSAP_CKK PF08683.11 AFZ79312.1 - 0.094 12.9 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Microtubule-binding calmodulin-regulated spectrin-associated DUF501 PF04417.12 AFZ79314.1 - 1.8e-13 50.5 0.0 2.3e-08 33.9 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF501) NDK PF00334.19 AFZ79315.1 - 3.3e-52 176.1 0.0 3.7e-52 175.9 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase SRP54 PF00448.22 AFZ79316.1 - 9.9e-57 191.7 0.2 1.9e-56 190.8 0.2 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.13 AFZ79316.1 - 2.4e-16 60.5 9.5 6.8e-11 42.6 0.1 2.3 1 1 1 2 2 2 2 Signal recognition particle, alpha subunit, N-terminal MeaB PF03308.16 AFZ79316.1 - 1.3e-06 27.6 0.0 3e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CbiA PF01656.23 AFZ79316.1 - 0.00011 22.3 3.6 0.00014 21.9 0.8 2.5 2 2 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain NTPase_1 PF03266.15 AFZ79316.1 - 0.00014 21.9 0.4 0.024 14.6 0.1 3.3 2 1 1 3 3 3 1 NTPase AAA_30 PF13604.6 AFZ79316.1 - 0.00014 21.7 0.0 0.00027 20.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain Fer4_NifH PF00142.18 AFZ79316.1 - 0.0014 18.2 0.0 0.0027 17.2 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54_N PF02881.19 AFZ79316.1 - 0.0027 17.9 0.1 0.012 15.8 0.1 2.2 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain DAP3 PF10236.9 AFZ79316.1 - 0.0032 16.7 0.7 0.008 15.4 0.0 1.9 2 0 0 2 2 2 1 Mitochondrial ribosomal death-associated protein 3 AAA_31 PF13614.6 AFZ79316.1 - 0.0035 17.3 1.2 0.0087 16.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 AFZ79316.1 - 0.0083 16.4 0.1 0.12 12.7 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 AFZ79316.1 - 0.01 16.2 0.0 0.034 14.5 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.6 AFZ79316.1 - 0.02 15.3 0.4 0.15 12.5 0.0 2.6 3 0 0 3 3 2 0 AAA domain RhoGAP-FF1 PF16512.5 AFZ79316.1 - 0.083 13.6 0.0 0.25 12.0 0.0 1.8 1 0 0 1 1 1 0 p190-A and -B Rho GAPs FF domain NACHT PF05729.12 AFZ79316.1 - 0.12 12.2 0.0 0.59 10.0 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_33 PF13671.6 AFZ79316.1 - 0.14 12.3 0.0 0.42 10.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF4889 PF16230.5 AFZ79319.1 - 0.15 12.3 4.2 0.2 11.9 1.8 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4889) SUI1 PF01253.22 AFZ79320.1 - 1.6e-14 54.1 0.1 2.4e-14 53.6 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 Peptidase_M41 PF01434.18 AFZ79321.1 - 1.4e-60 204.4 0.0 2.1e-60 203.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 AFZ79321.1 - 1.6e-41 141.8 0.0 3.1e-41 140.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AFZ79321.1 - 9.8e-10 38.1 0.6 2.3e-09 36.9 0.1 1.9 2 0 0 2 2 2 1 AAA+ lid domain AAA_22 PF13401.6 AFZ79321.1 - 5.8e-05 23.4 0.0 0.02 15.2 0.0 2.5 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.13 AFZ79321.1 - 0.00015 21.1 0.1 0.00037 19.8 0.0 1.7 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_5 PF07728.14 AFZ79321.1 - 0.00075 19.5 0.0 0.0035 17.3 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 AFZ79321.1 - 0.0015 18.3 0.0 0.0056 16.4 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AFZ79321.1 - 0.0076 16.6 0.1 0.11 12.9 0.1 2.4 1 1 0 2 2 2 1 AAA ATPase domain FtsH_ext PF06480.15 AFZ79321.1 - 0.008 16.5 0.1 0.14 12.5 0.1 2.6 1 1 0 1 1 1 1 FtsH Extracellular AAA_2 PF07724.14 AFZ79321.1 - 0.02 15.0 0.1 0.12 12.5 0.0 2.3 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 AFZ79321.1 - 0.033 13.9 0.1 0.067 12.9 0.1 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_17 PF13207.6 AFZ79321.1 - 0.056 13.9 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 AFZ79321.1 - 0.077 12.4 0.1 0.27 10.6 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 AFZ79321.1 - 0.081 13.5 0.0 0.23 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain NYD-SP28 PF14772.6 AFZ79321.1 - 0.092 12.8 0.1 0.2 11.7 0.1 1.5 1 0 0 1 1 1 0 Sperm tail TsaE PF02367.17 AFZ79321.1 - 0.095 12.7 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MCM PF00493.23 AFZ79321.1 - 0.16 11.1 0.0 0.45 9.6 0.0 1.7 2 0 0 2 2 2 0 MCM P-loop domain AAA_33 PF13671.6 AFZ79321.1 - 0.16 12.1 0.0 0.44 10.7 0.0 1.7 2 0 0 2 2 1 0 AAA domain Sigma54_activat PF00158.26 AFZ79321.1 - 0.18 11.5 0.0 0.49 10.1 0.0 1.6 1 1 0 1 1 1 0 Sigma-54 interaction domain DEAD PF00270.29 AFZ79322.1 - 2.6e-33 115.3 0.0 4.8e-33 114.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AFZ79322.1 - 9.7e-18 64.5 0.0 3.4e-17 62.8 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 AFZ79322.1 - 3.2e-17 62.5 0.2 1e-16 60.9 0.2 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Peptidase_S46 PF10459.9 AFZ79322.1 - 0.00035 19.4 3.7 0.00045 19.0 3.7 1.1 1 0 0 1 1 1 1 Peptidase S46 ResIII PF04851.15 AFZ79322.1 - 0.0018 18.3 0.7 0.01 15.9 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SPG4 PF17325.2 AFZ79323.1 - 0.017 16.2 0.2 0.04 15.0 0.2 1.6 1 0 0 1 1 1 0 Stationary phase protein 4 ThiF PF00899.21 AFZ79324.1 - 1.9e-43 148.6 1.2 2.7e-43 148.1 1.2 1.1 1 0 0 1 1 1 1 ThiF family NAD_binding_7 PF13241.6 AFZ79324.1 - 0.0072 16.7 0.3 0.025 15.0 0.2 2.0 2 0 0 2 2 2 1 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 AFZ79324.1 - 0.027 14.7 0.3 0.51 10.6 0.0 2.5 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain FAD_binding_3 PF01494.19 AFZ79324.1 - 0.028 13.7 0.5 0.051 12.8 0.5 1.4 1 0 0 1 1 1 0 FAD binding domain UDPG_MGDP_dh_N PF03721.14 AFZ79324.1 - 0.03 13.9 0.2 0.08 12.5 0.2 1.7 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 AFZ79324.1 - 0.03 13.7 0.1 0.075 12.4 0.1 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 AFZ79324.1 - 0.068 13.4 1.2 0.22 11.8 0.4 2.4 2 1 1 3 3 3 0 TrkA-N domain PglD_N PF17836.1 AFZ79324.1 - 0.1 13.2 4.7 0.14 12.9 1.5 2.3 1 1 1 2 2 2 0 PglD N-terminal domain DUF4342 PF14242.6 AFZ79324.1 - 0.15 12.1 1.8 0.28 11.2 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4342) Phi_1 PF04674.12 AFZ79325.1 - 0.041 13.2 0.6 0.12 11.6 0.1 1.8 2 0 0 2 2 2 0 Phosphate-induced protein 1 conserved region tRNA-synt_His PF13393.6 AFZ79326.1 - 1.2e-27 97.0 0.0 2.2e-27 96.2 0.0 1.4 1 0 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.25 AFZ79326.1 - 0.00071 19.6 0.0 0.0011 19.0 0.0 1.4 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) YflT PF11181.8 AFZ79326.1 - 0.0021 18.6 0.0 0.0047 17.4 0.0 1.6 1 0 0 1 1 1 1 Heat induced stress protein YflT eIF2A PF08662.11 AFZ79327.1 - 7.5e-55 185.8 1.0 1.8e-52 178.0 0.1 2.3 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A DUF3845 PF12956.7 AFZ79327.1 - 0.08 12.4 0.4 13 5.1 0.0 2.3 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure Brix PF04427.18 AFZ79328.1 - 5.2e-35 121.3 2.3 5.2e-35 121.3 2.3 2.2 2 1 0 2 2 2 1 Brix domain Rep_fac-A_C PF08646.10 AFZ79330.1 - 1.5e-24 86.4 1.7 2.7e-24 85.6 0.9 1.9 1 1 0 1 1 1 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 AFZ79330.1 - 1.6e-13 50.4 0.3 9.4e-11 41.5 0.0 2.7 2 0 0 2 2 2 2 Replication protein A OB domain tRNA_anti-codon PF01336.25 AFZ79330.1 - 1.1e-06 28.5 0.0 2.7e-05 24.1 0.0 2.5 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain DUF223 PF02721.14 AFZ79330.1 - 0.0046 17.2 0.1 0.021 15.1 0.1 2.1 1 0 0 1 1 1 1 Domain of unknown function DUF223 Diphthami_syn_2 PF01902.17 AFZ79331.1 - 1e-35 123.3 0.0 3.8e-35 121.4 0.0 1.7 1 1 0 1 1 1 1 Diphthamide synthase ATP-synt_F PF01990.17 AFZ79332.1 - 1.5e-30 105.4 0.3 1.7e-30 105.2 0.3 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit eIF-5_eIF-2B PF01873.17 AFZ79332.1 - 0.086 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Domain found in IF2B/IF5 DHHC PF01529.20 AFZ79333.1 - 3.8e-36 124.1 25.9 2.4e-35 121.5 16.3 2.2 2 0 0 2 2 2 2 DHHC palmitoyltransferase Colicin_V PF02674.16 AFZ79333.1 - 0.64 10.0 10.4 3 7.8 2.2 2.2 2 0 0 2 2 2 0 Colicin V production protein La PF05383.17 AFZ79335.1 - 6e-11 42.2 0.3 1.6e-10 40.9 0.3 1.7 1 0 0 1 1 1 1 La domain DUF3223 PF11523.8 AFZ79335.1 - 5.6e-10 39.9 0.1 1.5e-09 38.6 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3223) BfiI_DBD PF18243.1 AFZ79335.1 - 0.0041 16.7 0.1 0.053 13.1 0.0 2.2 2 0 0 2 2 2 1 Metal-independent restriction enzyme BfiI DNA binding domain LisH PF08513.11 AFZ79336.1 - 5.2e-11 42.1 0.1 1e-10 41.1 0.1 1.5 1 0 0 1 1 1 1 LisH ANAPC4_WD40 PF12894.7 AFZ79336.1 - 6.3e-09 36.0 0.2 0.0071 16.6 0.0 4.2 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AFZ79336.1 - 1.1e-07 32.4 8.7 0.0073 17.1 0.0 6.0 6 0 0 6 6 6 2 WD domain, G-beta repeat eIF2A PF08662.11 AFZ79336.1 - 8.8e-07 29.0 2.5 0.024 14.5 0.2 3.6 2 1 0 3 3 3 3 Eukaryotic translation initiation factor eIF2A RAB3GAP2_N PF14655.6 AFZ79336.1 - 0.0071 15.7 0.1 4.2 6.5 0.0 2.9 2 1 1 3 3 3 2 Rab3 GTPase-activating protein regulatory subunit N-terminus Coatomer_WDAD PF04053.14 AFZ79336.1 - 0.16 11.0 0.6 4.8 6.1 0.0 2.4 2 0 0 2 2 2 0 Coatomer WD associated region CDT1 PF08839.11 AFZ79337.1 - 4.2e-07 30.4 0.0 7.7e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 DNA replication factor CDT1 like Dcc1 PF09724.9 AFZ79338.1 - 1.1e-06 28.2 0.7 4e-05 23.1 0.2 2.3 2 0 0 2 2 2 2 Sister chromatid cohesion protein Dcc1 Ctf8 PF09696.10 AFZ79338.1 - 0.2 12.0 1.6 0.72 10.2 0.0 2.6 2 1 0 2 2 2 0 Ctf8 LisH PF08513.11 AFZ79339.1 - 5.2e-11 42.1 0.1 1e-10 41.1 0.1 1.5 1 0 0 1 1 1 1 LisH ANAPC4_WD40 PF12894.7 AFZ79339.1 - 4.7e-09 36.4 0.2 0.0052 17.0 0.0 4.2 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AFZ79339.1 - 1.2e-07 32.3 8.7 0.0073 17.1 0.0 6.0 6 0 0 6 6 6 2 WD domain, G-beta repeat eIF2A PF08662.11 AFZ79339.1 - 1.4e-06 28.4 2.5 0.024 14.5 0.2 3.6 2 1 0 3 3 3 3 Eukaryotic translation initiation factor eIF2A RAB3GAP2_N PF14655.6 AFZ79339.1 - 0.021 14.1 0.1 13 4.9 0.0 2.9 2 1 1 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Coatomer_WDAD PF04053.14 AFZ79339.1 - 0.18 10.8 0.7 4.8 6.1 0.0 2.4 2 0 0 2 2 2 0 Coatomer WD associated region CDT1 PF08839.11 AFZ79340.1 - 4.2e-07 30.4 0.0 7.7e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 DNA replication factor CDT1 like Mito_carr PF00153.27 AFZ79341.1 - 9e-52 173.0 0.3 1.4e-16 60.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1358 PF07096.11 AFZ79341.1 - 0.022 14.7 0.0 0.32 11.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1358) GTP1_OBG PF01018.22 AFZ79342.1 - 3.1e-24 85.3 0.2 4.2e-24 84.9 0.2 1.2 1 0 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.23 AFZ79342.1 - 6.8e-11 42.3 0.0 1.1e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AFZ79342.1 - 7.5e-07 28.8 0.0 1.6e-06 27.8 0.0 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 AFZ79342.1 - 0.00098 18.6 0.0 0.0016 17.9 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 AFZ79342.1 - 0.049 13.0 0.0 0.068 12.5 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Ubiq_cyt_C_chap PF03981.12 AFZ79343.1 - 1.3e-25 90.2 0.1 2.1e-25 89.5 0.1 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone RNase_T PF00929.24 AFZ79345.1 - 2.3e-16 60.8 0.1 1.9e-15 57.8 0.0 2.6 2 1 1 3 3 3 1 Exonuclease UCH_1 PF13423.6 AFZ79345.1 - 2.7e-09 37.1 0.0 9.8e-09 35.2 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Mon1 PF03164.14 AFZ79346.1 - 5.6e-73 246.3 2.1 6.7e-73 246.1 2.1 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 ABC_tran PF00005.27 AFZ79347.1 - 6.9e-34 117.3 0.0 1.9e-33 115.9 0.0 1.8 2 0 0 2 2 1 1 ABC transporter ABC_membrane PF00664.23 AFZ79347.1 - 1.4e-27 97.1 16.7 1.9e-27 96.6 16.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 AFZ79347.1 - 1e-07 31.6 0.0 0.00012 21.6 0.0 2.4 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 AFZ79347.1 - 0.00073 19.8 0.0 0.0053 17.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 AFZ79347.1 - 0.0017 17.6 0.0 0.0033 16.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 AFZ79347.1 - 0.0017 18.8 0.0 0.0052 17.2 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 AFZ79347.1 - 0.0048 16.7 0.4 1.7 8.4 0.0 2.5 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 AFZ79347.1 - 0.0066 16.2 0.1 0.015 15.0 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_24 PF13479.6 AFZ79347.1 - 0.01 15.5 0.2 0.026 14.3 0.1 1.7 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.20 AFZ79347.1 - 0.013 14.7 0.0 0.028 13.6 0.0 1.6 1 0 0 1 1 1 0 G-protein alpha subunit RsgA_GTPase PF03193.16 AFZ79347.1 - 0.026 14.4 0.0 0.066 13.1 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA_15 PF13175.6 AFZ79347.1 - 0.049 13.3 0.1 0.11 12.2 0.1 1.6 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 AFZ79347.1 - 0.052 13.6 0.1 0.28 11.3 0.0 2.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase ATP-synt_ab PF00006.25 AFZ79347.1 - 0.081 12.6 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF87 PF01935.17 AFZ79347.1 - 0.12 12.5 0.3 0.5 10.4 0.1 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain Zeta_toxin PF06414.12 AFZ79347.1 - 0.12 11.6 0.0 0.37 10.0 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin Arm PF00514.23 AFZ79348.1 - 0.00082 19.3 0.0 0.19 11.8 0.0 2.8 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat UNC45-central PF11701.8 AFZ79348.1 - 0.0028 17.6 0.2 0.63 10.0 0.0 3.2 2 1 2 4 4 4 1 Myosin-binding striated muscle assembly central RNA_pol_A_CTD PF03118.15 AFZ79348.1 - 0.0045 16.7 0.4 0.017 14.9 0.4 2.1 1 0 0 1 1 1 1 Bacterial RNA polymerase, alpha chain C terminal domain NusB PF01029.18 AFZ79348.1 - 1.2 9.4 7.1 0.25 11.6 1.3 2.7 2 1 1 3 3 3 0 NusB family Pkinase PF00069.25 AFZ79349.1 - 1.5e-10 40.9 0.0 2.5e-09 36.9 0.0 2.7 2 1 0 2 2 2 1 Protein kinase domain Rcd1 PF04078.13 AFZ79350.1 - 4.2e-113 376.9 3.1 4.9e-113 376.7 3.1 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like HypA PF01155.19 AFZ79351.1 - 0.021 14.8 2.1 0.021 14.8 2.1 1.3 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_6 PF14599.6 AFZ79351.1 - 0.046 13.7 3.6 0.079 13.0 3.6 1.4 1 0 0 1 1 1 0 Zinc-ribbon DNA_RNApol_7kD PF03604.13 AFZ79351.1 - 0.11 12.1 3.5 0.23 11.2 3.5 1.5 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit Tubulin PF00091.25 AFZ79352.1 - 9.1e-71 238.1 0.0 2.4e-70 236.7 0.0 1.7 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 AFZ79352.1 - 2.8e-42 143.8 0.2 4.2e-42 143.3 0.2 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 AFZ79352.1 - 2.4e-05 24.6 0.0 6.2e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 AFZ79352.1 - 0.0035 17.1 0.0 0.0072 16.0 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 AFZ79352.1 - 0.0039 16.4 0.1 0.009 15.2 0.0 1.6 2 0 0 2 2 2 1 Tubulin like FHA PF00498.26 AFZ79353.1 - 2.1e-16 60.0 0.1 8.9e-16 58.0 0.1 2.1 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 AFZ79353.1 - 4e-12 46.3 0.0 8.4e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DUF1533 PF07550.11 AFZ79353.1 - 0.076 12.9 0.3 0.4 10.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1533) ATG16 PF08614.11 AFZ79354.1 - 0.0012 19.1 4.1 0.0012 19.1 4.1 2.3 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) APG6_N PF17675.1 AFZ79354.1 - 0.0053 17.3 14.1 0.013 16.0 5.9 2.5 2 0 0 2 2 2 1 Apg6 coiled-coil region DUF1204 PF06721.11 AFZ79354.1 - 0.016 14.7 2.7 0.035 13.6 2.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1204) CENP-H PF05837.12 AFZ79354.1 - 0.022 15.2 5.5 0.022 15.2 5.5 2.5 2 0 0 2 2 2 0 Centromere protein H (CENP-H) DUF2968 PF11180.8 AFZ79354.1 - 0.023 14.3 9.0 0.048 13.3 2.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) CENP-F_leu_zip PF10473.9 AFZ79354.1 - 0.033 14.2 17.5 0.12 12.4 8.2 2.4 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 AFZ79354.1 - 0.097 12.0 18.5 0.28 10.5 7.1 2.4 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4164 PF13747.6 AFZ79354.1 - 0.22 11.8 11.6 0.63 10.4 2.5 2.7 3 0 0 3 3 2 0 Domain of unknown function (DUF4164) DivIC PF04977.15 AFZ79354.1 - 0.22 11.3 17.1 0.32 10.8 1.1 3.5 2 1 1 3 3 3 0 Septum formation initiator DUF4201 PF13870.6 AFZ79354.1 - 0.24 11.1 14.9 0.25 11.1 4.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) ZapB PF06005.12 AFZ79354.1 - 0.28 11.7 23.0 0.084 13.3 2.5 3.6 2 1 1 3 3 3 0 Cell division protein ZapB UPF0242 PF06785.11 AFZ79354.1 - 0.37 10.9 14.5 2 8.5 2.3 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus YabA PF06156.13 AFZ79354.1 - 0.77 10.4 14.3 4.5 8.0 1.0 3.0 2 1 1 3 3 3 0 Initiation control protein YabA TMF_TATA_bd PF12325.8 AFZ79354.1 - 0.92 9.8 14.5 0.97 9.7 6.4 2.6 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding NRBF2 PF08961.10 AFZ79354.1 - 1.1 8.8 10.1 3 7.4 1.3 3.1 2 1 1 3 3 3 0 Nuclear receptor-binding factor 2, autophagy regulator ADIP PF11559.8 AFZ79354.1 - 1.5 8.9 17.8 2.1 8.4 7.1 2.6 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding JAKMIP_CC3 PF16034.5 AFZ79354.1 - 1.6 8.7 13.6 0.42 10.5 0.9 2.9 2 1 1 3 3 3 0 JAKMIP CC3 domain PRKG1_interact PF15898.5 AFZ79354.1 - 1.6 9.6 15.0 5.8 7.9 5.8 2.8 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain HALZ PF02183.18 AFZ79354.1 - 2.1 8.6 12.9 5.9 7.2 2.8 3.6 2 1 2 4 4 4 0 Homeobox associated leucine zipper HIP1_clath_bdg PF16515.5 AFZ79354.1 - 2.2 8.9 14.0 5.9 7.6 1.6 2.8 3 0 0 3 3 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 bZIP_1 PF00170.21 AFZ79354.1 - 2.3 8.4 20.2 1.7 8.8 0.5 3.5 2 1 1 3 3 3 0 bZIP transcription factor Cep57_CLD_2 PF14197.6 AFZ79354.1 - 2.5 8.2 16.2 0.92 9.6 2.0 3.2 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 Occludin_ELL PF07303.13 AFZ79354.1 - 3 8.6 7.8 3.4 8.5 2.5 2.7 2 0 0 2 2 2 0 Occludin homology domain JIP_LZII PF16471.5 AFZ79354.1 - 3.2 8.0 13.6 0.3 11.3 0.7 3.4 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II Rootletin PF15035.6 AFZ79354.1 - 3.7 7.5 19.7 35 4.3 19.1 2.3 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion BRE1 PF08647.11 AFZ79354.1 - 4.6 7.4 15.1 6 7.0 5.4 2.5 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase DUF4407 PF14362.6 AFZ79354.1 - 6 6.1 9.9 45 3.2 9.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Seryl_tRNA_N PF02403.22 AFZ79354.1 - 7.8 6.8 15.4 0.96 9.7 6.3 2.8 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DNA_topoisoIV PF00521.20 AFZ79356.1 - 5.6e-128 427.5 0.0 1.2e-127 426.3 0.0 1.6 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 AFZ79356.1 - 9.2e-46 155.3 4.6 9.2e-46 155.3 4.6 2.1 2 0 0 2 2 2 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 AFZ79356.1 - 5.3e-24 84.6 1.8 1.3e-23 83.4 1.8 1.5 1 0 0 1 1 1 1 DNA gyrase B Toprim PF01751.22 AFZ79356.1 - 2.9e-07 30.6 0.0 9.1e-07 29.0 0.0 1.9 1 0 0 1 1 1 1 Toprim domain HATPase_c PF02518.26 AFZ79356.1 - 3.3e-07 30.8 0.1 5.5e-06 26.9 0.0 2.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Aurora-A_bind PF09041.10 AFZ79356.1 - 0.36 10.9 2.9 9.9 6.3 0.5 3.1 3 0 0 3 3 3 0 Aurora-A binding V-SNARE_C PF12352.8 AFZ79358.1 - 2.6e-06 27.6 2.0 3.7e-06 27.1 2.0 1.3 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Asp5 PF17000.5 AFZ79358.1 - 0.011 15.8 1.0 0.018 15.2 1.0 1.3 1 0 0 1 1 1 0 Accessory secretory protein Sec, Asp5 Sec20 PF03908.13 AFZ79358.1 - 0.04 13.8 1.0 0.081 12.8 1.0 1.7 1 1 0 1 1 1 0 Sec20 DNA_pol_D_N PF18018.1 AFZ79359.1 - 1.8e-25 89.5 0.0 2.7e-25 89.0 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain DNA_pol_E_B PF04042.16 AFZ79359.1 - 1.1e-24 87.0 0.4 2e-22 79.6 0.4 3.3 3 1 0 3 3 3 1 DNA polymerase alpha/epsilon subunit B Rootletin PF15035.6 AFZ79360.1 - 0.073 13.1 7.9 0.13 12.3 7.9 1.3 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Cupin_8 PF13621.6 AFZ79361.1 - 8.1e-29 101.1 0.0 1.2e-28 100.5 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 AFZ79361.1 - 8.8e-05 22.1 0.1 0.00023 20.8 0.1 1.6 1 1 0 1 1 1 1 Cupin superfamily protein APG5 PF04106.12 AFZ79363.1 - 0.058 13.0 0.0 0.06 12.9 0.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg5 TMEM43 PF07787.12 AFZ79364.1 - 1.5e-23 83.5 0.1 3.4e-23 82.3 0.1 1.6 1 1 0 1 1 1 1 Transmembrane protein 43 DAGK_acc PF00609.19 AFZ79366.1 - 2.9e-30 105.7 0.0 4.3e-30 105.2 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 AFZ79366.1 - 1.6e-16 60.1 0.0 6.3e-16 58.1 0.0 2.0 1 1 1 2 2 2 1 Diacylglycerol kinase catalytic domain TPR_14 PF13428.6 AFZ79367.1 - 1.1e-22 78.8 8.4 0.0098 16.6 0.1 12.2 7 2 7 14 14 12 6 Tetratricopeptide repeat TPR_19 PF14559.6 AFZ79367.1 - 1.1e-18 67.5 0.0 6.8e-05 23.3 0.0 7.3 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 AFZ79367.1 - 3.2e-15 55.0 6.2 0.2 12.0 0.0 10.3 11 0 0 11 11 9 2 Tetratricopeptide repeat TPR_17 PF13431.6 AFZ79367.1 - 1.3e-13 50.3 3.1 0.023 15.1 0.0 8.2 8 1 0 8 8 8 2 Tetratricopeptide repeat TPR_2 PF07719.17 AFZ79367.1 - 4.5e-13 48.2 20.7 0.024 14.7 0.0 10.5 12 0 0 12 12 11 4 Tetratricopeptide repeat HAT PF02184.16 AFZ79367.1 - 2.9e-11 43.1 55.8 7.4e-05 22.6 0.1 10.9 12 1 0 12 12 10 5 HAT (Half-A-TPR) repeat Suf PF05843.14 AFZ79367.1 - 5.3e-11 43.0 19.8 0.00023 21.3 0.7 6.2 2 2 4 6 6 6 4 Suppressor of forked protein (Suf) TPR_16 PF13432.6 AFZ79367.1 - 1.5e-09 38.3 1.7 2.1 9.1 0.1 6.4 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 AFZ79367.1 - 1.9e-07 30.6 10.0 4.2 7.4 0.0 7.8 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_7 PF13176.6 AFZ79367.1 - 9.7e-07 28.4 4.4 0.83 9.8 0.0 7.1 9 0 0 9 9 5 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 AFZ79367.1 - 1.4e-06 28.3 12.5 0.15 12.0 0.5 6.2 5 2 1 6 6 6 2 Mad3/BUB1 homology region 1 TPR_12 PF13424.6 AFZ79367.1 - 5.4e-06 26.6 3.2 16 5.9 0.0 7.9 7 1 0 8 8 8 0 Tetratricopeptide repeat TPR_11 PF13414.6 AFZ79367.1 - 7.3e-06 25.6 0.5 0.013 15.2 0.0 5.0 6 0 0 6 6 6 1 TPR repeat TPR_6 PF13174.6 AFZ79367.1 - 3.5e-05 24.2 12.5 8 7.3 0.2 8.1 10 0 0 10 10 6 1 Tetratricopeptide repeat NRDE-2 PF08424.10 AFZ79367.1 - 0.0032 16.6 14.9 0.11 11.6 0.1 5.3 3 2 0 3 3 3 2 NRDE-2, necessary for RNA interference TPR_9 PF13371.6 AFZ79367.1 - 0.0094 16.1 0.8 0.82 9.9 0.1 4.1 3 1 1 4 4 3 1 Tetratricopeptide repeat U3_assoc_6 PF08640.11 AFZ79367.1 - 0.011 15.8 13.5 0.32 11.1 0.3 5.9 5 1 1 6 6 6 0 U3 small nucleolar RNA-associated protein 6 TPR_15 PF13429.6 AFZ79367.1 - 0.031 13.5 9.7 0.051 12.8 0.4 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 AFZ79367.1 - 0.046 13.8 0.1 30 4.8 0.0 3.9 4 0 0 4 4 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_4 PF07721.14 AFZ79367.1 - 0.07 13.8 0.0 1.3 9.8 0.0 3.3 3 0 0 3 3 1 0 Tetratricopeptide repeat FliS PF02561.14 AFZ79367.1 - 0.12 12.7 1.6 9.5 6.5 0.1 4.1 5 0 0 5 5 4 0 Flagellar protein FliS FAINT PF04385.15 AFZ79368.1 - 1.6e-07 31.2 0.1 2.7e-06 27.4 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function, DUF529 Sperm_Ag_HE2 PF05324.13 AFZ79368.1 - 0.19 12.2 0.8 1.5 9.4 0.7 2.5 2 0 0 2 2 2 0 Sperm antigen HE2 FAINT PF04385.15 AFZ79369.1 - 2.5e-06 27.5 0.0 3.7e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79370.1 - 2.5e-15 56.3 12.2 9.4e-08 32.0 2.2 3.2 2 1 1 3 3 3 2 Domain of unknown function, DUF529 Elf1 PF05129.13 AFZ79371.1 - 0.0035 17.4 3.0 0.13 12.3 0.1 2.9 2 0 0 2 2 2 2 Transcription elongation factor Elf1 like FAINT PF04385.15 AFZ79372.1 - 1.2e-39 134.3 70.4 2.8e-06 27.3 4.7 13.6 12 1 0 12 12 12 10 Domain of unknown function, DUF529 PBP1_TM PF14812.6 AFZ79372.1 - 0.0056 17.0 1.8 0.017 15.5 1.8 1.8 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Astro_capsid_p PF12226.8 AFZ79372.1 - 0.56 9.3 16.8 1 8.4 16.8 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein NOA36 PF06524.12 AFZ79372.1 - 1.3 8.3 13.0 2.3 7.4 13.0 1.3 1 0 0 1 1 1 0 NOA36 protein PPP4R2 PF09184.11 AFZ79372.1 - 3.8 7.0 14.1 7.3 6.1 14.1 1.4 1 0 0 1 1 1 0 PPP4R2 Cwf_Cwc_15 PF04889.12 AFZ79372.1 - 3.9 7.1 13.1 7.5 6.2 13.1 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RXT2_N PF08595.11 AFZ79372.1 - 6.5 6.8 8.3 17 5.4 8.3 1.7 1 0 0 1 1 1 0 RXT2-like, N-terminal BUD22 PF09073.10 AFZ79372.1 - 7.2 5.8 12.4 12 5.1 12.4 1.2 1 0 0 1 1 1 0 BUD22 FAM176 PF14851.6 AFZ79372.1 - 9.8 5.8 6.5 21 4.8 6.5 1.5 1 0 0 1 1 1 0 FAM176 family DUF4178 PF13785.6 AFZ79373.1 - 0.11 12.7 0.0 5.8 7.0 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4178) AP2 PF00847.20 AFZ79374.1 - 3.1e-11 43.3 0.9 0.00014 22.0 0.0 2.6 3 0 0 3 3 3 2 AP2 domain Med14 PF08638.11 AFZ79375.1 - 8.1e-15 54.7 0.0 1.7e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 Mediator complex subunit MED14 SF3b10 PF07189.11 AFZ79376.1 - 1.5e-29 101.9 0.2 2.2e-29 101.4 0.1 1.3 1 1 1 2 2 2 1 Splicing factor 3B subunit 10 (SF3b10) Oxidoreduct_C PF16490.5 AFZ79376.1 - 0.043 13.5 0.1 0.048 13.4 0.1 1.0 1 0 0 1 1 1 0 Putative oxidoreductase C terminal domain E1-E2_ATPase PF00122.20 AFZ79377.1 - 0.029 13.9 0.1 0.14 11.6 0.0 2.3 2 0 0 2 2 2 0 E1-E2 ATPase Hydrolase_4 PF12146.8 AFZ79379.1 - 6.5e-23 81.2 0.0 3.1e-22 79.0 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FAINT PF04385.15 AFZ79379.1 - 2.1e-14 53.3 9.4 6.8e-06 26.1 1.6 4.2 3 0 0 3 3 3 3 Domain of unknown function, DUF529 Abhydrolase_2 PF02230.16 AFZ79379.1 - 0.00038 20.3 0.3 0.18 11.6 0.1 2.4 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 AFZ79379.1 - 0.0064 16.2 1.7 0.06 13.0 0.5 2.9 3 1 0 3 3 3 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 AFZ79379.1 - 0.076 12.5 0.2 0.92 8.9 0.1 2.4 2 0 0 2 2 2 0 Prolyl oligopeptidase family DUF1391 PF07151.12 AFZ79379.1 - 0.11 12.3 0.1 0.44 10.4 0.1 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1391) DUF1450 PF07293.11 AFZ79380.1 - 0.048 13.5 0.1 0.048 13.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1450) TIG PF01833.24 AFZ79381.1 - 0.016 15.2 0.1 0.76 9.9 0.0 3.3 2 1 0 2 2 2 0 IPT/TIG domain Leo1 PF04004.13 AFZ79383.1 - 7.9e-15 55.1 1.6 1.1e-14 54.6 1.6 1.4 1 1 0 1 1 1 1 Leo1-like protein DUF2433 PF10360.9 AFZ79384.1 - 0.00013 22.0 2.0 0.085 13.0 0.4 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF2433) Mod_r PF07200.13 AFZ79384.1 - 0.001 19.2 0.6 0.001 19.2 0.6 2.4 1 1 1 2 2 2 1 Modifier of rudimentary (Mod(r)) protein Laminin_II PF06009.12 AFZ79384.1 - 0.026 14.5 2.3 0.027 14.5 1.2 1.5 2 0 0 2 2 2 0 Laminin Domain II SCAPER_N PF16501.5 AFZ79384.1 - 0.069 13.2 1.9 0.11 12.6 0.8 1.9 1 1 0 2 2 2 0 S phase cyclin A-associated protein in the endoplasmic reticulum CM_2 PF01817.21 AFZ79384.1 - 0.19 12.1 2.6 0.48 10.8 0.5 2.6 3 0 0 3 3 3 0 Chorismate mutase type II DUF16 PF01519.16 AFZ79384.1 - 0.21 12.1 5.7 1.2 9.7 3.2 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 DASH_Spc34 PF08657.10 AFZ79384.1 - 0.25 11.1 4.8 0.6 9.9 0.9 2.1 1 1 1 2 2 2 0 DASH complex subunit Spc34 RAP PF08373.10 AFZ79385.1 - 2.6e-09 37.0 0.0 8.2e-09 35.4 0.0 1.9 1 0 0 1 1 1 1 RAP domain CS PF04969.16 AFZ79386.1 - 3.6e-05 24.7 0.0 5.8e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 CS domain Ribosomal_S6e PF01092.19 AFZ79387.1 - 1.8e-55 186.2 0.0 3.7e-55 185.2 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S6e FAINT PF04385.15 AFZ79388.1 - 0.01 15.9 0.0 0.023 14.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function, DUF529 FSAP_sig_propep PF03032.15 AFZ79388.1 - 0.11 12.6 0.7 0.26 11.3 0.7 1.6 1 0 0 1 1 1 0 Frog skin active peptide family signal and propeptide ATP-synt_D PF01813.17 AFZ79389.1 - 6e-54 182.9 1.3 7.1e-54 182.6 1.3 1.0 1 0 0 1 1 1 1 ATP synthase subunit D ABC_tran PF00005.27 AFZ79391.1 - 4.1e-29 101.9 0.0 3.3e-15 56.8 0.0 2.6 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 AFZ79391.1 - 3.6e-06 27.0 0.7 0.095 12.5 0.1 3.1 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 AFZ79391.1 - 6.5e-05 22.6 1.0 0.2 11.5 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 AFZ79391.1 - 0.00012 22.5 0.0 0.078 13.4 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 AFZ79391.1 - 0.00076 19.3 0.1 0.63 9.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 AFZ79391.1 - 0.0011 18.8 0.4 0.45 10.2 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 AFZ79391.1 - 0.0017 18.3 0.5 0.22 11.4 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_18 PF13238.6 AFZ79391.1 - 0.0021 18.6 0.1 3.3 8.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.6 AFZ79391.1 - 0.0024 18.4 2.7 0.76 10.2 0.4 2.6 2 0 0 2 2 2 2 AAA domain DUF87 PF01935.17 AFZ79391.1 - 0.0048 17.0 3.9 0.088 12.9 0.1 3.0 3 0 0 3 3 3 1 Helicase HerA, central domain DnaB_C PF03796.15 AFZ79391.1 - 0.0073 15.7 0.0 0.059 12.7 0.0 2.1 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain Zeta_toxin PF06414.12 AFZ79391.1 - 0.0081 15.5 0.2 3.3 6.9 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin MMR_HSR1 PF01926.23 AFZ79391.1 - 0.0098 16.0 0.2 0.18 11.9 0.1 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 AFZ79391.1 - 0.014 15.6 0.0 3.1 8.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 AFZ79391.1 - 0.016 14.6 0.5 1.6 8.0 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family NACHT PF05729.12 AFZ79391.1 - 0.017 15.1 0.5 3 7.8 0.1 2.5 2 0 0 2 2 2 0 NACHT domain MeaB PF03308.16 AFZ79391.1 - 0.024 13.6 0.7 0.05 12.6 0.0 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB SbcCD_C PF13558.6 AFZ79391.1 - 0.03 14.5 0.0 0.069 13.4 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Dynamin_N PF00350.23 AFZ79391.1 - 0.036 14.1 0.1 6.8 6.7 0.0 2.6 2 0 0 2 2 2 0 Dynamin family T2SSE PF00437.20 AFZ79391.1 - 0.04 13.0 0.8 7.2 5.6 0.1 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein SMC_N PF02463.19 AFZ79391.1 - 0.059 12.8 2.9 0.24 10.8 0.2 2.6 2 1 0 3 3 3 0 RecF/RecN/SMC N terminal domain NB-ARC PF00931.22 AFZ79391.1 - 0.098 11.8 0.7 1.8 7.7 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain AAA_25 PF13481.6 AFZ79391.1 - 0.11 12.0 0.1 2.2 7.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 AFZ79391.1 - 0.11 12.2 0.1 14 5.3 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein NTPase_1 PF03266.15 AFZ79391.1 - 0.14 12.1 0.3 8.2 6.3 0.1 2.4 2 0 0 2 2 2 0 NTPase TsaE PF02367.17 AFZ79391.1 - 0.21 11.6 0.7 3.9 7.5 0.1 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE cobW PF02492.19 AFZ79391.1 - 0.33 10.5 3.7 6.8 6.3 0.1 2.9 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain MINDY_DUB PF04424.13 AFZ79392.1 - 6.4e-16 58.4 0.0 1.9e-15 56.9 0.0 1.8 2 0 0 2 2 2 1 MINDY deubiquitinase Sec63 PF02889.16 AFZ79393.1 - 3.4e-27 95.3 0.1 4.9e-27 94.7 0.1 1.2 1 0 0 1 1 1 1 Sec63 Brl domain DnaJ PF00226.31 AFZ79393.1 - 9.3e-19 67.3 0.1 2.3e-18 66.1 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain DUF3149 PF11346.8 AFZ79393.1 - 0.0062 16.1 0.6 0.017 14.7 0.6 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3149) Rep_Org_C PF06926.11 AFZ79393.1 - 0.014 15.7 0.2 1.8 8.9 0.1 2.5 2 0 0 2 2 2 0 Putative replisome organiser protein C-terminus DUF1327 PF07041.11 AFZ79394.1 - 0.12 12.4 1.1 0.9 9.6 0.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1327) ATG16 PF08614.11 AFZ79394.1 - 0.2 11.8 24.0 0.18 12.0 7.9 3.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) TolA_bind_tri PF16331.5 AFZ79394.1 - 0.43 10.7 16.5 0.63 10.2 1.4 4.8 3 1 1 4 4 4 0 TolA binding protein trimerisation Cortex-I_coil PF09304.10 AFZ79394.1 - 2.6 8.3 28.4 0.24 11.6 10.1 3.9 1 1 3 4 4 4 0 Cortexillin I, coiled coil NYD-SP28 PF14772.6 AFZ79394.1 - 9.5 6.3 31.6 0.49 10.5 0.9 4.1 1 1 3 4 4 4 0 Sperm tail YbjQ_1 PF01906.17 AFZ79395.1 - 0.15 12.7 0.0 0.42 11.3 0.0 1.7 2 0 0 2 2 2 0 Putative heavy-metal-binding Solute_trans_a PF03619.16 AFZ79396.1 - 3.2e-48 164.6 19.0 3.9e-48 164.3 19.0 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Sec34 PF04136.15 AFZ79396.1 - 0.038 13.9 1.7 0.06 13.2 1.7 1.3 1 0 0 1 1 1 0 Sec34-like family NAF PF03822.14 AFZ79396.1 - 0.08 13.1 0.1 0.08 13.1 0.1 1.9 2 0 0 2 2 2 0 NAF domain cNMP_binding PF00027.29 AFZ79397.1 - 2.5e-39 133.2 0.0 6e-21 74.3 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain DUF572 PF04502.13 AFZ79400.1 - 0.087 12.4 13.7 0.097 12.3 13.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) CAF-1_p150 PF11600.8 AFZ79400.1 - 0.19 11.4 30.1 0.35 10.6 30.1 1.4 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Asp-B-Hydro_N PF05279.11 AFZ79400.1 - 0.83 9.7 14.6 0.97 9.5 14.6 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region SAGA-Tad1 PF12767.7 AFZ79400.1 - 1.4 8.6 10.7 1.9 8.2 10.7 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit AP2 PF00847.20 AFZ79401.1 - 6.3e-07 29.5 0.4 1.4e-06 28.4 0.4 1.6 1 0 0 1 1 1 1 AP2 domain ALMT PF11744.8 AFZ79401.1 - 0.039 12.8 1.4 0.039 12.8 0.1 1.6 2 0 0 2 2 2 0 Aluminium activated malate transporter DEAD PF00270.29 AFZ79402.1 - 3.2e-38 131.2 0.0 1.7e-37 128.9 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AFZ79402.1 - 2.1e-25 89.2 0.1 7.9e-25 87.4 0.1 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AFZ79402.1 - 2.7e-08 34.0 0.1 2.3e-07 31.0 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF4217 PF13959.6 AFZ79402.1 - 6.7e-07 29.4 0.0 1.5e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ERCC3_RAD25_C PF16203.5 AFZ79402.1 - 9.6e-06 25.0 0.1 9.6e-06 25.0 0.1 2.0 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase AAA_22 PF13401.6 AFZ79402.1 - 0.02 15.2 2.5 0.072 13.4 0.5 2.8 2 1 0 2 2 2 0 AAA domain CAF1A PF12253.8 AFZ79403.1 - 2.4e-08 34.0 5.4 1.1e-07 32.0 5.4 2.1 1 0 0 1 1 1 1 Chromatin assembly factor 1 subunit A DUF4279 PF14106.6 AFZ79403.1 - 0.045 14.0 0.2 12 6.2 0.0 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4279) NARP1 PF12569.8 AFZ79403.1 - 0.44 9.4 8.1 0.79 8.6 8.1 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 SURF2 PF05477.11 AFZ79403.1 - 6.3 6.4 12.4 0.63 9.7 5.9 2.3 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) PHO4 PF01384.20 AFZ79405.1 - 8.5e-98 327.5 14.0 1e-97 327.2 14.0 1.1 1 0 0 1 1 1 1 Phosphate transporter family Spc29 PF17082.5 AFZ79406.1 - 0.0019 18.1 1.9 0.0024 17.8 1.9 1.1 1 0 0 1 1 1 1 Spindle Pole Component 29 DUF1993 PF09351.10 AFZ79406.1 - 0.021 15.0 0.1 0.4 10.8 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1993) DUF2570 PF10828.8 AFZ79406.1 - 0.038 13.8 0.1 0.1 12.4 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) TBCA PF02970.16 AFZ79406.1 - 0.057 13.8 4.5 1.6 9.1 0.7 2.6 1 1 1 2 2 2 0 Tubulin binding cofactor A KLRAQ PF10205.9 AFZ79406.1 - 0.69 10.2 8.1 0.11 12.7 0.5 2.6 1 1 2 3 3 3 0 Predicted coiled-coil domain-containing protein ERM PF00769.19 AFZ79406.1 - 3.5 7.4 9.3 0.72 9.6 1.0 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family cNMP_binding PF00027.29 AFZ79407.1 - 1.5e-28 98.7 0.0 1.3e-08 34.8 0.0 4.7 4 0 0 4 4 4 4 Cyclic nucleotide-binding domain EF-hand_8 PF13833.6 AFZ79407.1 - 0.00012 21.8 0.2 0.93 9.4 0.1 3.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 AFZ79407.1 - 0.00066 19.4 0.0 0.054 13.4 0.0 3.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 AFZ79407.1 - 0.0045 16.4 0.4 0.02 14.4 0.1 2.4 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.32 AFZ79407.1 - 0.0075 15.7 0.1 0.0075 15.7 0.1 4.3 5 0 0 5 5 5 1 EF hand EF-hand_7 PF13499.6 AFZ79407.1 - 0.18 12.3 0.0 0.18 12.3 0.0 4.4 4 1 1 5 5 5 0 EF-hand domain pair GUCT PF08152.12 AFZ79407.1 - 1.3 9.3 8.3 16 5.9 1.1 3.1 2 0 0 2 2 2 0 GUCT (NUC152) domain HSA PF07529.13 AFZ79409.1 - 4.5e-06 26.9 0.4 1.1e-05 25.7 0.4 1.7 1 0 0 1 1 1 1 HSA GlutR_N PF05201.15 AFZ79409.1 - 0.0041 16.9 0.0 0.0079 16.0 0.0 1.4 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, N-terminal domain Peptidase_C54 PF03416.19 AFZ79410.1 - 6.4e-43 147.1 0.1 7.8e-43 146.9 0.1 1.1 1 0 0 1 1 1 1 Peptidase family C54 FAINT PF04385.15 AFZ79411.1 - 5.7e-20 71.2 9.0 9e-07 28.9 0.3 4.1 3 1 1 4 4 4 3 Domain of unknown function, DUF529 TSA PF03249.13 AFZ79411.1 - 0.38 9.5 2.9 0.58 8.9 2.9 1.2 1 0 0 1 1 1 0 Type specific antigen Not1 PF04054.15 AFZ79412.1 - 2.9e-43 148.2 7.1 1.3e-42 146.0 7.1 2.1 1 1 0 1 1 1 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 AFZ79412.1 - 1.2e-35 122.9 0.3 4e-35 121.2 0.3 1.9 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 AFZ79412.1 - 6.4e-22 78.1 0.4 5.7e-21 75.0 0.3 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3819) CNOT1_TTP_bind PF16417.5 AFZ79412.1 - 0.003 16.8 3.2 0.0082 15.3 0.0 3.1 4 0 0 4 4 4 1 CCR4-NOT transcription complex subunit 1 TTP binding domain DKCLD PF08068.12 AFZ79413.1 - 1.1e-31 108.6 0.1 6.7e-31 106.2 0.2 2.2 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_N PF01509.18 AFZ79413.1 - 3.7e-24 85.8 0.3 3.8e-21 76.0 0.3 3.1 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 AFZ79413.1 - 1.8e-22 79.3 0.2 3.5e-22 78.3 0.2 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 AFZ79413.1 - 8.6e-18 64.1 2.5 1.9e-17 63.0 2.5 1.6 1 0 0 1 1 1 1 PUA domain G8 PF10162.9 AFZ79413.1 - 0.012 15.7 0.1 0.027 14.6 0.1 1.6 1 1 0 1 1 1 0 G8 domain UPF0113 PF03657.13 AFZ79413.1 - 0.051 13.8 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 UPF0113 PUA domain DEAD PF00270.29 AFZ79414.1 - 3.9e-21 75.6 0.0 6.4e-21 74.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AFZ79414.1 - 5.5e-18 65.3 0.1 5e-16 59.0 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 AFZ79414.1 - 1.5e-13 51.3 2.4 5.1e-13 49.5 2.4 2.0 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.15 AFZ79414.1 - 1.9e-05 24.8 0.0 4e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DTC PF18102.1 AFZ79415.1 - 5.5e-28 97.7 0.0 9e-28 97.1 0.0 1.3 1 0 0 1 1 1 1 Deltex C-terminal domain zf-RING_2 PF13639.6 AFZ79415.1 - 4.4e-08 33.3 5.2 6.6e-08 32.8 5.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 AFZ79415.1 - 7.7e-06 25.7 4.3 1.3e-05 24.9 4.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AFZ79415.1 - 0.00016 21.7 4.2 0.00027 20.9 4.2 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 AFZ79415.1 - 0.00025 20.9 5.1 0.0004 20.2 5.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 AFZ79415.1 - 0.00026 20.7 3.0 0.00065 19.4 3.0 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 AFZ79415.1 - 0.00042 20.5 2.7 0.00096 19.4 2.7 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 AFZ79415.1 - 0.0017 18.4 0.2 0.0033 17.4 0.2 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 AFZ79415.1 - 0.0045 16.9 3.4 0.013 15.5 3.6 1.6 1 1 0 1 1 1 1 zinc-RING finger domain zf-Nse PF11789.8 AFZ79415.1 - 0.016 15.0 2.5 0.031 14.1 2.5 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit PHD PF00628.29 AFZ79415.1 - 0.026 14.4 0.8 0.043 13.7 0.8 1.4 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_3 PF13920.6 AFZ79415.1 - 0.046 13.6 3.1 0.071 13.0 3.1 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 AFZ79415.1 - 0.1 12.7 6.0 0.16 12.1 6.0 1.3 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-Di19 PF05605.12 AFZ79415.1 - 0.18 12.1 2.9 10 6.5 0.5 2.4 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Zn_ribbon_17 PF17120.5 AFZ79415.1 - 0.27 10.9 3.4 0.23 11.1 1.7 1.8 2 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type Zf_RING PF16744.5 AFZ79415.1 - 0.32 11.1 1.7 0.59 10.3 1.7 1.5 1 0 0 1 1 1 0 KIAA1045 RING finger Prok-RING_1 PF14446.6 AFZ79415.1 - 0.32 10.9 2.0 0.5 10.3 0.2 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Prok-RING_4 PF14447.6 AFZ79415.1 - 2.9 7.8 6.8 78 3.2 0.3 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Dpy19 PF10034.9 AFZ79416.1 - 1.5e-49 168.9 35.4 3.8e-37 127.8 23.9 2.0 1 1 1 2 2 2 2 Q-cell neuroblast polarisation TMEM126 PF07114.11 AFZ79416.1 - 0.0008 18.8 1.3 0.0017 17.8 1.3 1.5 1 0 0 1 1 1 1 Transmembrane protein 126 Dpy19 PF10034.9 AFZ79417.1 - 6.6e-24 84.1 2.1 8.6e-24 83.7 2.1 1.1 1 0 0 1 1 1 1 Q-cell neuroblast polarisation SKIP_SNW PF02731.15 AFZ79418.1 - 1.3e-67 226.4 5.1 1.3e-67 226.4 5.1 2.0 3 0 0 3 3 3 1 SKIP/SNW domain GBP PF02263.19 AFZ79419.1 - 4.8e-23 81.7 3.4 2.2e-13 50.1 0.0 4.4 4 0 0 4 4 4 3 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 AFZ79419.1 - 0.0086 16.1 0.7 0.099 12.7 0.8 2.7 2 1 0 2 2 2 1 Dynamin family DUF4720 PF15846.5 AFZ79419.1 - 0.011 15.5 0.6 0.036 13.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4720) MMR_HSR1 PF01926.23 AFZ79419.1 - 0.065 13.3 0.3 0.95 9.6 0.3 2.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase YtpI PF14007.6 AFZ79419.1 - 4.3 7.6 7.9 0.64 10.2 1.9 2.5 3 0 0 3 3 3 0 YtpI-like protein DnaJ-X PF14308.6 AFZ79421.1 - 1.1e-41 142.7 0.9 2.3e-41 141.6 0.1 1.9 2 0 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 AFZ79421.1 - 9.7e-24 83.3 3.8 3.6e-23 81.5 2.3 2.5 2 0 0 2 2 2 1 DnaJ domain Glyco_tran_28_C PF04101.16 AFZ79422.1 - 7.1e-19 68.4 0.0 8.9e-19 68.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain LUC7 PF03194.15 AFZ79423.1 - 8.5e-71 238.6 2.7 1.6e-70 237.7 2.7 1.4 1 0 0 1 1 1 1 LUC7 N_terminus Amnionless PF14828.6 AFZ79423.1 - 0.064 12.1 0.1 0.093 11.5 0.1 1.3 1 0 0 1 1 1 0 Amnionless Viral_P18 PF04521.13 AFZ79423.1 - 0.064 13.0 0.1 0.15 11.8 0.1 1.6 1 0 0 1 1 1 0 ssRNA positive strand viral 18kD cysteine rich protein DUF3597 PF12200.8 AFZ79423.1 - 0.43 11.1 3.5 1.1 9.8 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) Apt1 PF10351.9 AFZ79423.1 - 4.4 6.1 14.8 7.6 5.3 14.8 1.4 1 0 0 1 1 1 0 Golgi-body localisation protein domain rRNA_proc-arch PF13234.6 AFZ79424.1 - 5.7e-46 157.6 1.9 1e-45 156.8 1.9 1.4 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.12 AFZ79424.1 - 2.4e-44 150.9 0.1 5.2e-44 149.8 0.1 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 AFZ79424.1 - 7.4e-20 71.4 0.0 2.9e-19 69.5 0.0 2.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AFZ79424.1 - 1.3e-07 31.9 0.0 8.5e-07 29.3 0.0 2.4 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AFZ79424.1 - 4.8e-06 26.7 0.0 1.2e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit IL6 PF00489.17 AFZ79424.1 - 0.014 15.0 0.2 0.082 12.5 0.0 2.2 2 0 0 2 2 2 0 Interleukin-6/G-CSF/MGF family AAA_22 PF13401.6 AFZ79424.1 - 0.042 14.1 0.0 0.28 11.5 0.0 2.4 1 1 1 2 2 2 0 AAA domain PhoH PF02562.16 AFZ79424.1 - 0.12 11.8 0.0 0.27 10.6 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein Com_YlbF PF06133.11 AFZ79424.1 - 0.49 11.0 2.8 0.99 10.0 0.2 2.7 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA CBM_21 PF03370.13 AFZ79425.1 - 0.048 13.8 0.3 0.091 12.9 0.0 1.6 2 0 0 2 2 2 0 Carbohydrate/starch-binding module (family 21) POLO_box PF00659.18 AFZ79425.1 - 0.12 12.6 0.2 0.72 10.1 0.1 2.1 2 0 0 2 2 2 0 POLO box duplicated region Gag_p24 PF00607.20 AFZ79425.1 - 0.17 11.7 0.0 0.31 10.9 0.0 1.3 1 0 0 1 1 1 0 gag gene protein p24 (core nucleocapsid protein) FAINT PF04385.15 AFZ79427.1 - 3.2e-58 193.7 62.8 3.8e-05 23.6 0.0 16.2 16 0 0 16 16 16 14 Domain of unknown function, DUF529 Viral_P18 PF04521.13 AFZ79427.1 - 0.0026 17.5 0.0 0.007 16.1 0.0 1.7 1 0 0 1 1 1 1 ssRNA positive strand viral 18kD cysteine rich protein ABC_tran PF00005.27 AFZ79428.1 - 3.6e-27 95.5 0.0 1e-15 58.5 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_16 PF13191.6 AFZ79428.1 - 0.00017 22.0 0.0 0.15 12.4 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 AFZ79428.1 - 0.0003 20.6 0.1 0.16 11.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 AFZ79428.1 - 0.00035 20.3 0.6 0.31 10.8 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain DnaB_C PF03796.15 AFZ79428.1 - 0.0021 17.5 0.0 0.16 11.3 0.0 2.4 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain Zeta_toxin PF06414.12 AFZ79428.1 - 0.007 15.7 0.3 1.3 8.2 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin FtsK_SpoIIIE PF01580.18 AFZ79428.1 - 0.0081 15.5 0.4 1.8 7.8 0.0 2.2 2 0 0 2 2 2 1 FtsK/SpoIIIE family RsgA_GTPase PF03193.16 AFZ79428.1 - 0.0098 15.8 0.7 0.36 10.7 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 AFZ79428.1 - 0.013 15.8 0.2 3.3 8.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain VraX PF17412.2 AFZ79428.1 - 0.019 14.6 0.2 0.071 12.8 0.2 1.9 1 0 0 1 1 1 0 Family of unknown function ATP_bind_1 PF03029.17 AFZ79428.1 - 0.023 14.5 0.3 5.8 6.6 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 AFZ79428.1 - 0.027 15.0 0.1 5.4 7.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 AFZ79428.1 - 0.029 13.3 0.9 0.057 12.4 0.1 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Fer4_NifH PF00142.18 AFZ79428.1 - 0.033 13.6 0.2 5.4 6.4 0.0 2.3 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family T2SSE PF00437.20 AFZ79428.1 - 0.046 12.8 1.5 5.3 6.0 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_21 PF13304.6 AFZ79428.1 - 0.086 12.6 0.8 5.7 6.7 0.0 2.8 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 AFZ79428.1 - 0.088 12.9 2.7 0.19 11.8 0.1 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain SMC_N PF02463.19 AFZ79428.1 - 0.12 11.8 1.0 0.98 8.8 0.1 2.3 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain P3A PF08727.11 AFZ79428.1 - 0.13 11.7 0.1 0.32 10.4 0.1 1.6 1 0 0 1 1 1 0 Poliovirus 3A protein like AAA_25 PF13481.6 AFZ79428.1 - 0.15 11.6 0.1 1.9 8.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 AFZ79428.1 - 0.18 12.1 0.3 8.8 6.7 0.1 3.0 2 1 0 2 2 2 0 AAA domain cobW PF02492.19 AFZ79428.1 - 0.22 11.1 0.6 14 5.2 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 AFZ79428.1 - 0.28 11.3 1.2 0.9 9.6 0.2 2.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_23 PF13476.6 AFZ79428.1 - 0.4 11.1 3.0 13 6.2 0.1 2.5 2 0 0 2 2 2 0 AAA domain MAT1 PF06391.13 AFZ79431.1 - 1.4e-10 41.4 8.9 2.1e-10 40.8 8.9 1.2 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_3 PF13920.6 AFZ79431.1 - 7.6e-05 22.5 10.4 0.00019 21.2 10.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AFZ79431.1 - 0.00079 19.7 7.2 0.00079 19.7 7.2 2.1 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 AFZ79431.1 - 0.0016 18.3 7.4 0.005 16.7 7.4 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_5 PF17121.5 AFZ79431.1 - 0.0025 17.7 5.8 0.0065 16.3 5.8 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AFZ79431.1 - 0.027 14.4 9.3 0.087 12.8 9.3 1.9 1 1 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 AFZ79431.1 - 0.042 13.9 6.7 0.097 12.7 5.8 2.1 1 1 1 2 2 2 0 RING-type zinc-finger PAPS_reduct PF01507.19 AFZ79431.1 - 0.11 12.5 0.6 0.21 11.6 0.5 1.5 2 0 0 2 2 2 0 Phosphoadenosine phosphosulfate reductase family RED_C PF07807.11 AFZ79431.1 - 0.18 12.3 1.3 0.36 11.3 1.3 1.6 1 1 0 1 1 1 0 RED-like protein C-terminal region zf-C3HC4_2 PF13923.6 AFZ79431.1 - 0.37 10.7 11.7 0.84 9.5 9.8 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 AFZ79431.1 - 1 9.2 9.3 0.28 11.0 0.8 2.8 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_4 PF14570.6 AFZ79431.1 - 1.5 8.7 9.7 3.9 7.4 7.4 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain T6SS_HCP PF05638.12 AFZ79433.1 - 0.025 15.0 0.2 0.061 13.7 0.2 1.6 1 0 0 1 1 1 0 Type VI secretion system effector, Hcp RecA PF00154.21 AFZ79433.1 - 0.06 12.8 0.0 0.09 12.2 0.0 1.2 1 0 0 1 1 1 0 recA bacterial DNA recombination protein C2 PF00168.30 AFZ79434.1 - 2.2e-18 66.5 0.0 2.4e-05 24.5 0.0 5.4 7 0 0 7 7 7 4 C2 domain ATG22 PF11700.8 AFZ79434.1 - 0.063 11.9 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like E1-E2_ATPase PF00122.20 AFZ79435.1 - 1.7e-48 164.5 1.3 1.7e-48 164.5 1.3 2.6 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 AFZ79435.1 - 6.2e-46 156.4 2.2 6.2e-46 156.4 2.2 2.4 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 AFZ79435.1 - 8e-19 68.7 1.7 2.7e-17 63.8 1.7 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 AFZ79435.1 - 1.8e-15 56.8 0.1 4.2e-15 55.6 0.1 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 AFZ79435.1 - 6.1e-12 45.1 0.0 1.5e-11 43.8 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus HAD PF12710.7 AFZ79435.1 - 0.00011 22.7 0.0 0.00037 20.9 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 AFZ79435.1 - 0.0019 18.0 2.3 0.0062 16.3 1.4 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Holin_SPP1 PF04688.13 AFZ79435.1 - 0.051 13.7 0.5 0.2 11.9 0.5 2.0 1 0 0 1 1 1 0 SPP1 phage holin TRM PF02005.16 AFZ79436.1 - 3.9e-98 329.1 0.1 2.7e-75 253.9 0.0 2.0 2 0 0 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase DUF2067 PF09840.9 AFZ79436.1 - 0.024 14.2 0.0 0.041 13.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2067) Methyltransf_16 PF10294.9 AFZ79436.1 - 0.031 14.0 0.0 0.052 13.3 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Collagen PF01391.18 AFZ79438.1 - 2.9 7.7 26.6 3.1e+02 1.2 26.6 2.6 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) 60KD_IMP PF02096.20 AFZ79439.1 - 0.48 10.3 2.8 0.32 10.9 0.3 2.0 2 0 0 2 2 2 0 60Kd inner membrane protein UFD1 PF03152.14 AFZ79441.1 - 5.3e-72 240.9 0.0 7e-72 240.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 PEX-1N PF09262.11 AFZ79441.1 - 0.032 14.6 0.0 0.064 13.7 0.0 1.4 1 0 0 1 1 1 0 Peroxisome biogenesis factor 1, N-terminal CX9C PF16860.5 AFZ79442.1 - 0.00011 22.2 2.6 0.00011 22.2 2.6 2.8 1 1 2 3 3 3 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 AFZ79442.1 - 0.00097 19.2 1.8 0.00097 19.2 1.8 2.6 2 0 0 2 2 2 1 CHCH domain NDUF_B7 PF05676.13 AFZ79442.1 - 0.47 10.2 3.7 2.7 7.8 1.4 2.5 1 1 0 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.10 AFZ79442.1 - 1.4 9.0 6.5 0.42 10.7 2.2 2.3 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like MCM PF00493.23 AFZ79443.1 - 6.1e-90 300.2 0.0 1.2e-89 299.3 0.0 1.5 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 AFZ79443.1 - 6.2e-32 110.1 0.0 1.2e-31 109.2 0.0 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 AFZ79443.1 - 1.3e-18 67.1 0.1 3.8e-18 65.7 0.1 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 AFZ79443.1 - 8.3e-08 32.8 0.0 3e-07 31.0 0.0 2.0 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 AFZ79443.1 - 1.6e-07 30.9 0.1 6.9e-05 22.3 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 AFZ79443.1 - 0.00017 21.6 0.0 0.00044 20.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 AFZ79443.1 - 0.0002 21.1 0.0 0.78 9.4 0.0 2.3 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_3 PF07726.11 AFZ79443.1 - 0.035 14.0 0.0 0.12 12.2 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AFZ79443.1 - 0.071 13.5 0.2 0.27 11.6 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain DEK_C PF08766.11 AFZ79444.1 - 1.1e-07 31.6 0.2 2.4e-07 30.6 0.2 1.6 1 0 0 1 1 1 1 DEK C terminal domain DUF2894 PF11445.8 AFZ79444.1 - 0.21 12.0 2.6 0.29 11.6 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2894) DUF1075 PF06388.11 AFZ79447.1 - 0.012 15.7 0.1 0.015 15.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1075) Omp28 PF11551.8 AFZ79448.1 - 0.12 12.2 0.3 13 5.6 0.0 2.2 2 0 0 2 2 2 0 Outer membrane protein Omp28 DUF1681 PF07933.14 AFZ79450.1 - 0.11 12.3 0.0 3.1 7.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1681) 5_3_exonuc_N PF02739.16 AFZ79453.1 - 2.8e-29 102.1 0.0 2.8e-23 82.6 0.0 2.3 2 0 0 2 2 2 2 5'-3' exonuclease, N-terminal resolvase-like domain 5_3_exonuc PF01367.20 AFZ79453.1 - 3e-19 69.4 0.0 6.2e-19 68.4 0.0 1.5 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 AFZ79453.1 - 0.026 15.1 0.0 0.054 14.1 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.9 AFZ79453.1 - 0.037 13.9 0.0 0.083 12.7 0.0 1.5 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda FAINT PF04385.15 AFZ79455.1 - 1.1e-47 160.0 35.4 8.9e-09 35.3 1.8 9.1 8 1 0 8 8 8 8 Domain of unknown function, DUF529 DUF2510 PF10708.9 AFZ79455.1 - 0.00029 20.5 1.9 2.7 7.8 0.0 3.5 3 0 0 3 3 3 2 Protein of unknown function (DUF2510) WPP PF13943.6 AFZ79455.1 - 0.002 18.5 0.4 0.47 10.9 0.0 3.5 3 0 0 3 3 3 1 WPP domain Spt4 PF06093.13 AFZ79457.1 - 4.7e-06 26.6 0.0 5.1e-06 26.5 0.0 1.0 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Importin_rep_6 PF18829.1 AFZ79460.1 - 0.061 13.5 1.4 1.1 9.4 0.1 2.5 2 0 0 2 2 2 0 Importin repeat 6 CDT1_C PF16679.5 AFZ79460.1 - 0.19 12.2 1.3 0.85 10.1 0.6 2.4 2 0 0 2 2 2 0 DNA replication factor Cdt1 C-terminal domain Sel1 PF08238.12 AFZ79461.1 - 1.8e-20 72.9 6.3 1.5e-05 25.5 0.4 7.3 8 0 0 8 8 8 4 Sel1 repeat Pico_P2A PF00947.19 AFZ79462.1 - 0.022 14.8 0.3 0.063 13.3 0.3 1.7 1 0 0 1 1 1 0 Picornavirus core protein 2A CC190 PF15768.5 AFZ79464.1 - 0.025 14.7 0.1 0.05 13.7 0.1 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 190 UnbV_ASPIC PF07593.12 AFZ79464.1 - 0.038 14.0 0.1 0.17 11.9 0.0 2.1 2 0 0 2 2 2 0 ASPIC and UnbV RVT_1 PF00078.27 AFZ79466.1 - 4.3e-35 121.2 0.1 7.5e-35 120.4 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CE2_N PF17996.1 AFZ79467.1 - 0.029 14.3 0.3 0.73 9.8 0.0 2.0 2 0 0 2 2 2 0 Carbohydrate esterase 2 N-terminal FAINT PF04385.15 AFZ79467.1 - 0.16 12.1 0.3 0.33 11.0 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79468.1 - 1.9e-46 156.0 27.8 7.3e-07 29.2 0.2 9.7 9 0 0 9 9 9 9 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79469.1 - 0.00012 22.0 0.0 0.00029 20.8 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function, DUF529 RRM_1 PF00076.22 AFZ79470.1 - 2.7e-15 56.0 0.0 4.4e-15 55.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 AFZ79470.1 - 5.8e-06 25.9 0.0 7.4e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NucS PF01939.16 AFZ79471.1 - 0.037 13.4 0.1 0.06 12.7 0.1 1.2 1 0 0 1 1 1 0 Endonuclease NucS TLV_coat PF00429.19 AFZ79471.1 - 0.17 10.5 2.0 0.31 9.7 2.0 1.4 1 0 0 1 1 1 0 ENV polyprotein (coat polyprotein) GyrB_insert PF18053.1 AFZ79471.1 - 0.33 10.8 1.8 1.6 8.5 0.4 2.4 2 1 1 3 3 3 0 DNA gyrase B subunit insert domain NPV_P10 PF05531.12 AFZ79471.1 - 1.3 9.5 3.7 0.55 10.7 1.0 1.7 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Integrase_DNA PF02920.15 AFZ79472.1 - 0.24 11.1 6.9 4 7.2 2.5 2.8 2 0 0 2 2 2 0 DNA binding domain of tn916 integrase AAR2 PF05282.11 AFZ79474.1 - 0.11 11.8 1.3 0.19 11.1 1.3 1.3 1 0 0 1 1 1 0 AAR2 protein tRNA-synt_1 PF00133.22 AFZ79475.1 - 6.8e-87 292.1 0.1 1.7e-85 287.5 0.1 2.2 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 AFZ79475.1 - 2e-14 53.8 1.3 8.4e-14 51.8 1.3 2.1 1 1 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 AFZ79475.1 - 2.2e-11 43.1 1.1 1.5e-07 30.6 0.1 4.6 4 1 0 4 4 4 1 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 AFZ79475.1 - 0.032 13.7 0.1 0.083 12.4 0.1 1.7 1 0 0 1 1 1 0 Leucyl-tRNA synthetase, Domain 2 FAINT PF04385.15 AFZ79476.1 - 3.4e-07 30.2 0.2 5.1e-07 29.6 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function, DUF529 Hydrolase_4 PF12146.8 AFZ79477.1 - 7.3e-18 64.7 0.0 4e-17 62.3 0.0 2.1 2 1 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 AFZ79477.1 - 1.1e-09 38.2 16.9 3.5e-05 23.8 0.3 4.8 3 2 2 5 5 5 3 Domain of unknown function, DUF529 Abhydrolase_6 PF12697.7 AFZ79477.1 - 0.0012 19.5 0.0 0.0026 18.4 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 AFZ79477.1 - 0.02 14.8 0.0 0.066 13.1 0.0 1.8 2 0 0 2 2 2 0 alpha/beta hydrolase fold Sulf_coat_C PF12193.8 AFZ79477.1 - 0.04 14.0 0.1 0.21 11.7 0.1 2.1 2 0 0 2 2 2 0 Sulfolobus virus coat protein C terminal RRM_1 PF00076.22 AFZ79479.1 - 3.6e-20 71.5 0.0 6.2e-20 70.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) U1snRNP70_N PF12220.8 AFZ79479.1 - 7.6e-19 68.2 3.5 1.1e-18 67.6 3.5 1.3 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_8 PF11835.8 AFZ79479.1 - 0.02 15.1 0.0 0.032 14.4 0.0 1.3 1 0 0 1 1 1 0 RRM-like domain RRM_5 PF13893.6 AFZ79479.1 - 0.031 13.9 0.0 0.04 13.5 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 AFZ79479.1 - 0.11 12.8 1.0 0.27 11.5 1.0 1.8 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter NAD_binding_1 PF00175.21 AFZ79480.1 - 2e-12 47.7 0.0 3.8e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 AFZ79480.1 - 8.1e-08 32.5 0.0 2.5e-06 27.8 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 AFZ79480.1 - 2.5e-07 30.9 0.3 6.7e-05 23.1 0.0 2.2 1 1 1 2 2 2 2 Ferric reductase NAD binding domain ODV-E18 PF10717.9 AFZ79482.1 - 0.078 12.9 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 FAINT PF04385.15 AFZ79484.1 - 4.2e-10 39.5 0.2 1.1e-08 35.0 0.0 2.6 2 1 1 3 3 3 1 Domain of unknown function, DUF529 Ras PF00071.22 AFZ79485.1 - 1.3e-10 41.1 0.0 2.4e-09 37.0 0.1 2.2 2 1 0 2 2 2 1 Ras family GTP_EFTU PF00009.27 AFZ79485.1 - 0.017 14.7 0.1 0.032 13.8 0.1 1.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain TAFII55_N PF04658.13 AFZ79486.1 - 1.3e-23 83.5 0.0 2.5e-23 82.5 0.0 1.5 1 0 0 1 1 1 1 TAFII55 protein conserved region DBR1 PF05011.13 AFZ79487.1 - 5.3e-16 59.3 0.2 1.6e-15 57.7 0.1 1.9 2 1 0 2 2 2 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 AFZ79487.1 - 2.5e-11 44.5 0.5 3.7e-11 43.9 0.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 AFZ79487.1 - 0.0012 19.1 0.0 0.0035 17.6 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain SIP1 PF04938.12 AFZ79488.1 - 6.9e-09 35.7 0.0 0.00048 19.9 0.0 2.3 2 0 0 2 2 2 2 Survival motor neuron (SMN) interacting protein 1 (SIP1) Nop PF01798.18 AFZ79489.1 - 4.5e-79 265.2 0.0 6.5e-79 264.6 0.0 1.2 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 AFZ79489.1 - 4.2e-17 62.3 1.0 8.7e-17 61.3 1.0 1.6 1 0 0 1 1 1 1 NOP5NT (NUC127) domain YqzH PF14164.6 AFZ79491.1 - 0.097 12.8 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 YqzH-like protein DUF3721 PF12518.8 AFZ79492.1 - 0.59 10.0 1.5 1.1 9.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function Sulfate_transp PF00916.20 AFZ79493.1 - 3.6e-23 81.9 28.9 3.6e-23 81.9 28.9 2.4 2 1 0 2 2 2 1 Sulfate permease family Herpes_U55 PF06501.11 AFZ79493.1 - 0.00046 19.1 0.5 0.00073 18.4 0.5 1.2 1 0 0 1 1 1 1 Human herpesvirus U55 protein STAS PF01740.21 AFZ79493.1 - 0.00081 19.0 0.0 0.0016 18.0 0.0 1.4 1 0 0 1 1 1 1 STAS domain DUF4916 PF16262.5 AFZ79493.1 - 0.21 11.1 0.3 0.68 9.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4916) MFS_MOT1 PF16983.5 AFZ79493.1 - 9 6.7 30.3 0.55 10.6 2.7 4.4 4 1 0 4 4 4 0 Molybdate transporter of MFS superfamily FAINT PF04385.15 AFZ79498.1 - 4.8e-19 68.2 16.8 1.9e-07 31.0 1.7 5.0 5 0 0 5 5 5 4 Domain of unknown function, DUF529 Myb_DNA-bind_6 PF13921.6 AFZ79498.1 - 0.17 12.2 3.2 4 7.8 0.0 2.9 3 0 0 3 3 3 0 Myb-like DNA-binding domain FAINT PF04385.15 AFZ79500.1 - 4.7e-09 36.2 0.0 7.6e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 OprF PF05736.11 AFZ79500.1 - 0.12 12.1 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 OprF membrane domain FAINT PF04385.15 AFZ79501.1 - 1.9e-12 47.1 0.0 0.0057 16.7 0.0 3.4 3 0 0 3 3 3 3 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79502.1 - 4.4e-12 45.9 3.1 3.2e-05 23.9 0.6 2.6 2 1 0 2 2 2 2 Domain of unknown function, DUF529 DUF2510 PF10708.9 AFZ79502.1 - 0.043 13.6 0.1 0.15 11.8 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2510) COX_ARM PF06481.14 AFZ79502.1 - 0.22 11.5 1.0 0.39 10.6 0.2 1.9 2 0 0 2 2 2 0 COX Aromatic Rich Motif DUF21 PF01595.20 AFZ79503.1 - 1.3e-35 122.7 1.0 2.1e-35 122.0 1.0 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 AFZ79503.1 - 0.0035 17.7 3.0 0.62 10.6 0.2 3.1 3 0 0 3 3 3 2 CBS domain Profilin PF00235.19 AFZ79504.1 - 9.8e-18 64.6 0.1 1.3e-17 64.2 0.1 1.2 1 0 0 1 1 1 1 Profilin Methyltr_RsmB-F PF01189.17 AFZ79505.1 - 1.6e-67 227.0 0.0 2.6e-67 226.3 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 AFZ79505.1 - 3.8e-09 36.9 0.0 9.1e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 AFZ79505.1 - 3.9e-05 23.8 0.0 7.3e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Fibrillarin PF01269.17 AFZ79505.1 - 0.00051 19.2 0.0 0.00086 18.5 0.0 1.3 1 0 0 1 1 1 1 Fibrillarin Met_10 PF02475.16 AFZ79505.1 - 0.0028 17.4 0.0 0.0084 15.9 0.0 1.7 2 0 0 2 2 2 1 Met-10+ like-protein PCMT PF01135.19 AFZ79505.1 - 0.0033 17.2 0.0 0.0054 16.5 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) AIRS_C PF02769.22 AFZ79505.1 - 0.062 13.4 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 AIR synthase related protein, C-terminal domain Ras PF00071.22 AFZ79508.1 - 1.8e-53 180.5 0.1 2.2e-53 180.2 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AFZ79508.1 - 6.9e-31 107.0 0.0 1.1e-30 106.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AFZ79508.1 - 7.2e-13 48.4 0.1 8.4e-13 48.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AFZ79508.1 - 3.2e-06 26.7 0.1 3.7e-06 26.5 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 AFZ79508.1 - 6.2e-06 25.9 0.1 7.9e-06 25.5 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 AFZ79508.1 - 0.0014 18.6 0.0 0.0024 17.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AFZ79508.1 - 0.013 15.5 0.1 0.24 11.3 0.1 2.1 2 0 0 2 2 2 0 RsgA GTPase Raptor_N PF14538.6 AFZ79508.1 - 0.014 15.3 0.1 1.3 9.0 0.0 2.2 1 1 1 2 2 2 0 Raptor N-terminal CASPase like domain DAP3 PF10236.9 AFZ79508.1 - 0.072 12.2 0.1 0.17 11.0 0.0 1.6 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 Proteasome PF00227.26 AFZ79510.1 - 1.2e-38 132.5 0.0 3.4e-20 72.3 0.0 2.1 2 0 0 2 2 2 2 Proteasome subunit RICTOR_N PF14664.6 AFZ79510.1 - 0.21 10.5 0.0 0.33 9.9 0.0 1.2 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term Collar PF07484.12 AFZ79511.1 - 0.21 11.6 0.0 1.2 9.2 0.0 2.2 3 0 0 3 3 3 0 Phage Tail Collar Domain CdiI_2 PF18593.1 AFZ79512.1 - 0.053 14.2 0.2 0.42 11.3 0.0 2.5 3 0 0 3 3 3 0 CdiI immunity protein Rhomboid PF01694.22 AFZ79513.1 - 1.8e-20 73.4 22.0 1.6e-13 51.0 13.5 2.7 3 0 0 3 3 3 2 Rhomboid family UN_NPL4 PF11543.8 AFZ79514.1 - 2.8e-13 50.2 0.0 4.6e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 DCX PF03607.17 AFZ79514.1 - 0.11 12.6 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Doublecortin Rieske PF00355.26 AFZ79515.1 - 0.038 13.9 0.9 0.28 11.1 0.0 2.5 2 0 0 2 2 2 0 Rieske [2Fe-2S] domain zf-H2C2_2 PF13465.6 AFZ79516.1 - 0.07 13.6 0.2 0.21 12.1 0.2 1.8 1 0 0 1 1 1 0 Zinc-finger double domain JmjC PF02373.22 AFZ79516.1 - 0.072 13.5 0.1 13 6.3 0.0 2.8 3 0 0 3 3 3 0 JmjC domain, hydroxylase NPL4 PF05021.15 AFZ79517.1 - 2.6e-31 109.1 0.0 5.9e-29 101.4 0.0 3.0 1 1 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 AFZ79517.1 - 2.6e-07 30.9 0.2 1.6e-06 28.3 0.0 1.9 1 1 1 2 2 2 1 NPL4 family, putative zinc binding region Ala_racemase_N PF01168.20 AFZ79519.1 - 1.6e-14 54.1 0.1 2e-14 53.8 0.1 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain DUF5511 PF17630.2 AFZ79519.1 - 0.13 12.5 0.1 0.27 11.5 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5511) Rhomboid PF01694.22 AFZ79520.1 - 2.6e-30 105.4 15.2 2.6e-30 105.4 15.2 1.7 2 0 0 2 2 2 1 Rhomboid family DUF3671 PF12420.8 AFZ79520.1 - 0.033 14.3 0.2 14 5.8 0.1 2.9 2 2 0 2 2 2 0 Protein of unknown function Ribosomal_L4 PF00573.22 AFZ79522.1 - 2.9e-41 141.3 0.6 2.9e-41 141.3 0.6 1.9 2 0 0 2 2 2 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 AFZ79522.1 - 0.00076 19.5 3.8 0.0017 18.3 0.0 2.5 1 1 1 2 2 2 1 60S ribosomal protein L4 C-terminal domain ECH_2 PF16113.5 AFZ79522.1 - 0.018 14.6 0.3 0.024 14.1 0.3 1.2 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase FlaF PF07309.11 AFZ79522.1 - 0.064 13.3 0.2 0.12 12.4 0.2 1.4 1 0 0 1 1 1 0 Flagellar protein FlaF PIF1 PF05970.14 AFZ79522.1 - 0.066 12.4 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 PIF1-like helicase MORN PF02493.20 AFZ79523.1 - 1.7e-06 27.5 7.4 0.00042 20.0 1.4 3.2 2 0 0 2 2 2 2 MORN repeat HABP4_PAI-RBP1 PF04774.15 AFZ79525.1 - 0.51 11.2 7.0 0.75 10.7 6.6 1.4 1 1 0 1 1 1 0 Hyaluronan / mRNA binding family FAINT PF04385.15 AFZ79526.1 - 2.7e-12 46.6 0.0 9.4e-07 28.8 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Xpo1 PF08389.12 AFZ79527.1 - 0.00018 21.6 2.8 0.013 15.6 0.1 4.2 5 0 0 5 5 5 1 Exportin 1-like protein Trehalose_PPase PF02358.16 AFZ79527.1 - 0.017 14.3 0.0 0.089 11.9 0.0 2.0 2 0 0 2 2 2 0 Trehalose-phosphatase DsbC_N PF10411.9 AFZ79527.1 - 0.074 12.5 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 Disulfide bond isomerase protein N-terminus IBN_N PF03810.19 AFZ79528.1 - 0.012 15.5 0.1 0.015 15.2 0.1 1.3 1 0 0 1 1 1 0 Importin-beta N-terminal domain Statherin PF03875.13 AFZ79530.1 - 3.3 7.9 4.7 5.6 7.2 4.7 1.3 1 0 0 1 1 1 0 Statherin A_deaminase_N PF08451.11 AFZ79531.1 - 0.13 12.6 1.5 0.18 12.2 0.4 1.8 1 1 0 1 1 1 0 Adenosine/AMP deaminase N-terminal Guanylate_kin PF00625.21 AFZ79532.1 - 2.6e-46 157.6 0.0 3e-46 157.4 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_18 PF13238.6 AFZ79532.1 - 0.00042 20.9 0.8 0.0046 17.5 0.8 2.4 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 AFZ79532.1 - 0.00063 19.9 0.0 0.009 16.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 AFZ79532.1 - 0.0019 18.6 0.0 0.0028 18.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 AFZ79532.1 - 0.0027 17.6 0.1 0.0046 16.9 0.0 1.4 1 1 0 1 1 1 1 NTPase NB-ARC PF00931.22 AFZ79532.1 - 0.0047 16.2 0.0 0.0072 15.5 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 AFZ79532.1 - 0.0053 17.0 0.0 0.0093 16.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain Roc PF08477.13 AFZ79532.1 - 0.008 16.4 0.0 0.014 15.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_14 PF13173.6 AFZ79532.1 - 0.011 15.8 0.0 0.017 15.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 AFZ79532.1 - 0.012 16.0 0.2 0.016 15.6 0.2 1.6 1 1 0 1 1 1 0 AAA ATPase domain ADK PF00406.22 AFZ79532.1 - 0.013 15.6 0.9 12 6.0 0.2 3.0 1 1 2 3 3 3 0 Adenylate kinase RsgA_GTPase PF03193.16 AFZ79532.1 - 0.015 15.2 0.0 0.024 14.6 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_17 PF13207.6 AFZ79532.1 - 0.02 15.3 0.3 0.1 13.0 0.3 2.1 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 AFZ79532.1 - 0.022 15.3 0.0 0.03 14.9 0.0 1.4 1 1 0 1 1 1 0 ABC transporter AAA_5 PF07728.14 AFZ79532.1 - 0.027 14.5 0.0 0.048 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 AFZ79532.1 - 0.031 13.8 0.0 0.063 12.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region EFP PF01132.20 AFZ79532.1 - 0.035 14.1 0.1 0.061 13.4 0.1 1.3 1 0 0 1 1 1 0 Elongation factor P (EF-P) OB domain NACHT PF05729.12 AFZ79532.1 - 0.051 13.5 0.0 0.13 12.2 0.0 1.6 2 0 0 2 2 2 0 NACHT domain RNA_helicase PF00910.22 AFZ79532.1 - 0.058 13.8 0.0 0.14 12.6 0.0 1.7 2 0 0 2 2 2 0 RNA helicase SRPRB PF09439.10 AFZ79532.1 - 0.085 12.3 0.0 0.18 11.2 0.0 1.6 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit TsaE PF02367.17 AFZ79532.1 - 0.09 12.8 0.1 0.5 10.4 0.0 2.1 2 1 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 AFZ79532.1 - 0.16 11.7 0.1 0.34 10.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 AFZ79532.1 - 0.16 11.3 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PFK PF00365.20 AFZ79533.1 - 9.4e-60 202.3 0.0 1.4e-36 126.3 0.0 3.4 3 1 0 3 3 3 2 Phosphofructokinase Pilin_PilA PF14245.6 AFZ79534.1 - 0.013 15.5 0.0 0.027 14.4 0.0 1.5 1 0 0 1 1 1 0 Type IV pilin PilA Glyco_hydro_1 PF00232.18 AFZ79534.1 - 0.053 11.9 0.5 0.099 11.0 0.5 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 1 Pro_isomerase PF00160.21 AFZ79535.1 - 1.1e-49 168.8 0.0 1.8e-49 168.1 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rtf2 PF04641.12 AFZ79535.1 - 6.5e-06 25.7 0.0 3.2e-05 23.4 0.0 2.0 1 1 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.8 AFZ79535.1 - 7.6e-05 22.4 1.6 0.0028 17.4 0.8 3.3 2 1 2 4 4 4 2 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.15 AFZ79535.1 - 0.0001 22.4 0.3 0.018 15.2 0.0 3.1 4 0 0 4 4 4 1 U-box domain zf-NOSIP PF15906.5 AFZ79535.1 - 0.00089 19.3 0.0 0.0027 17.8 0.0 1.8 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein DUF3524 PF12038.8 AFZ79536.1 - 0.059 13.2 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3524) CK_II_beta PF01214.18 AFZ79539.1 - 1.6e-60 204.0 0.0 2.1e-60 203.7 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit zinc_ribbon_4 PF13717.6 AFZ79539.1 - 0.056 13.4 0.3 0.14 12.1 0.3 1.6 1 0 0 1 1 1 0 zinc-ribbon domain Tmemb_9 PF05434.11 AFZ79539.1 - 0.13 12.2 0.3 0.21 11.4 0.3 1.2 1 0 0 1 1 1 0 TMEM9 PseudoU_synth_2 PF00849.22 AFZ79541.1 - 0.051 13.7 0.0 0.06 13.4 0.0 1.4 1 1 0 1 1 1 0 RNA pseudouridylate synthase EAP30 PF04157.16 AFZ79541.1 - 0.17 11.2 0.0 0.28 10.4 0.0 1.3 1 0 0 1 1 1 0 EAP30/Vps36 family RNase_H2_suC PF08615.11 AFZ79542.1 - 1.1e-13 51.5 0.0 4.1e-13 49.7 0.0 1.7 1 1 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) TLD PF07534.16 AFZ79545.1 - 2.1e-31 109.0 2.6 4.4e-31 107.9 2.6 1.6 1 0 0 1 1 1 1 TLD PPP4R2 PF09184.11 AFZ79547.1 - 0.00082 19.1 0.3 0.0013 18.4 0.3 1.3 1 0 0 1 1 1 1 PPP4R2 7TMR-HDED PF07697.11 AFZ79549.1 - 0.055 13.6 0.3 0.074 13.2 0.3 1.2 1 0 0 1 1 1 0 7TM-HD extracellular DEAD_assoc PF08494.11 AFZ79549.1 - 0.17 11.7 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 DEAD/H associated Nop PF01798.18 AFZ79550.1 - 6.7e-58 195.9 0.3 9.2e-58 195.4 0.3 1.2 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 AFZ79550.1 - 2e-36 125.6 1.5 3.8e-36 124.7 1.5 1.5 1 0 0 1 1 1 1 Prp31 C terminal domain ubiquitin PF00240.23 AFZ79551.1 - 4.7e-25 87.1 0.3 5.1e-25 87.0 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 AFZ79551.1 - 1.7e-14 53.3 0.3 1.9e-14 53.2 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 AFZ79551.1 - 1.2e-06 28.6 0.1 2.7e-06 27.4 0.1 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 AFZ79551.1 - 0.00086 19.6 0.2 0.00094 19.5 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin-like domain DUF2407 PF10302.9 AFZ79551.1 - 0.0015 19.0 0.0 0.0018 18.8 0.0 1.1 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Ubiquitin_2 PF14560.6 AFZ79551.1 - 0.0016 18.9 0.1 0.0055 17.1 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain TUG-UBL1 PF11470.8 AFZ79551.1 - 0.044 14.0 0.1 0.43 10.8 0.0 2.0 1 1 0 1 1 1 0 TUG ubiquitin-like domain Pro_isomerase PF00160.21 AFZ79552.1 - 2.3e-40 138.5 0.0 3.5e-40 137.8 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF3408 PF11888.8 AFZ79552.1 - 0.0097 16.1 10.0 0.015 15.4 10.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3408) Velvet PF11754.8 AFZ79552.1 - 0.021 14.8 0.9 0.031 14.2 0.9 1.2 1 0 0 1 1 1 0 Velvet factor Ribosomal_60s PF00428.19 AFZ79552.1 - 0.071 13.7 6.8 0.24 12.0 6.8 1.9 1 0 0 1 1 1 0 60s Acidic ribosomal protein LRR_4 PF12799.7 AFZ79553.1 - 2.2e-06 27.9 21.8 1.4 9.5 0.4 6.2 5 2 2 7 7 7 4 Leucine Rich repeats (2 copies) Ubiquitin_2 PF14560.6 AFZ79553.1 - 3.7e-06 27.3 0.1 3.2e-05 24.3 0.0 2.6 2 1 0 3 3 3 1 Ubiquitin-like domain CAP_GLY PF01302.25 AFZ79553.1 - 1.9e-05 24.6 0.3 6.1e-05 23.0 0.3 1.8 1 1 0 1 1 1 1 CAP-Gly domain LRR_9 PF14580.6 AFZ79553.1 - 0.0017 17.9 1.8 8.8 5.8 0.3 3.7 3 1 1 4 4 4 2 Leucine-rich repeat LRR_8 PF13855.6 AFZ79553.1 - 0.023 14.5 0.6 0.023 14.5 0.6 5.7 4 2 2 6 6 6 0 Leucine rich repeat Ubiquitin_4 PF18036.1 AFZ79553.1 - 0.073 13.1 0.0 7.6 6.7 0.0 2.8 2 0 0 2 2 2 0 Ubiquitin-like domain PCNA_N PF00705.18 AFZ79554.1 - 9.1e-26 90.0 0.7 2.7e-25 88.5 0.4 1.9 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 AFZ79554.1 - 1.2e-18 67.6 0.2 2.3e-17 63.4 0.1 2.3 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 AFZ79554.1 - 5.8e-09 35.8 0.2 4.3e-08 32.9 0.2 2.0 1 1 0 1 1 1 1 Rad9 Rad1 PF02144.16 AFZ79554.1 - 9.6e-06 24.9 0.7 0.00019 20.6 0.6 2.3 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 PCM1_C PF15717.5 AFZ79556.1 - 1.5 7.4 8.5 2.4 6.8 8.5 1.2 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus Thioredoxin PF00085.20 AFZ79557.1 - 4.1e-26 91.0 0.0 6.9e-26 90.2 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 AFZ79557.1 - 2.5e-05 24.7 0.3 0.00057 20.3 0.3 2.3 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 AFZ79557.1 - 0.00024 21.3 0.1 0.02 15.2 0.1 2.3 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_3 PF13192.6 AFZ79557.1 - 0.00057 19.9 0.1 0.0039 17.2 0.0 2.2 3 0 0 3 3 3 1 Thioredoxin domain Thioredoxin_6 PF13848.6 AFZ79557.1 - 0.028 14.3 0.0 0.037 13.9 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain AhpC-TSA PF00578.21 AFZ79557.1 - 0.05 13.5 0.0 0.075 13.0 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA family OST3_OST6 PF04756.13 AFZ79557.1 - 0.053 12.9 0.0 0.12 11.7 0.0 1.8 1 1 1 2 2 2 0 OST3 / OST6 family, transporter family HyaE PF07449.11 AFZ79557.1 - 0.15 12.0 0.0 0.32 11.0 0.0 1.5 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Thioredoxin_4 PF13462.6 AFZ79557.1 - 0.17 12.1 0.1 4 7.6 0.1 2.6 2 1 1 3 3 3 0 Thioredoxin RsgA_GTPase PF03193.16 AFZ79558.1 - 1e-07 32.0 2.0 5.3e-07 29.7 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 AFZ79558.1 - 5.5e-07 29.7 4.2 4.9e-06 26.6 2.9 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 AFZ79558.1 - 7.3e-05 22.4 3.8 0.007 15.9 0.1 2.7 2 1 1 3 3 3 2 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 AFZ79558.1 - 0.024 15.1 0.1 0.076 13.5 0.1 1.8 1 0 0 1 1 1 0 ABC transporter AAA_23 PF13476.6 AFZ79558.1 - 0.037 14.5 0.4 0.037 14.5 0.4 2.4 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 AFZ79558.1 - 0.063 13.0 0.1 0.14 11.9 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSE PF00437.20 AFZ79558.1 - 0.075 12.1 0.1 0.13 11.3 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Arf PF00025.21 AFZ79558.1 - 0.083 12.3 0.9 1.4 8.3 0.0 2.4 1 1 1 2 2 2 0 ADP-ribosylation factor family cobW PF02492.19 AFZ79558.1 - 0.088 12.4 0.4 0.35 10.5 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Gtr1_RagA PF04670.12 AFZ79558.1 - 0.096 12.0 0.3 0.21 10.9 0.2 1.6 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 AFZ79558.1 - 0.26 10.8 1.7 0.29 10.6 0.1 2.0 3 0 0 3 3 3 0 Ferrous iron transport protein B Dynamin_N PF00350.23 AFZ79558.1 - 0.68 10.0 4.5 2 8.5 0.7 2.9 2 1 0 2 2 2 0 Dynamin family AAA_15 PF13175.6 AFZ79558.1 - 4.6 6.8 9.6 0.58 9.8 0.4 2.2 2 0 0 2 2 2 0 AAA ATPase domain PRCC PF10253.9 AFZ79559.1 - 3.9e-13 50.7 15.2 9.8e-13 49.4 14.8 2.0 1 1 0 1 1 1 1 Mitotic checkpoint regulator, MAD2B-interacting Abhydro_lipase PF04083.16 AFZ79559.1 - 0.14 11.8 0.0 0.41 10.3 0.0 1.8 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region Mito_carr PF00153.27 AFZ79560.1 - 3.9e-51 170.9 5.0 1.8e-20 72.7 0.3 4.1 1 1 2 3 3 3 3 Mitochondrial carrier protein CAP PF00188.26 AFZ79560.1 - 0.071 14.0 2.7 0.35 11.7 2.7 2.1 1 1 0 1 1 1 0 Cysteine-rich secretory protein family 14-3-3 PF00244.20 AFZ79562.1 - 4.9e-98 327.0 9.4 5.6e-98 326.9 9.4 1.0 1 0 0 1 1 1 1 14-3-3 protein Peptidase_C98 PF15499.6 AFZ79562.1 - 0.015 14.8 0.2 0.023 14.2 0.2 1.5 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase PhoU_div PF01865.16 AFZ79562.1 - 0.021 14.2 1.2 0.029 13.7 0.4 1.5 2 0 0 2 2 2 0 Protein of unknown function DUF47 DUF3106 PF11304.8 AFZ79562.1 - 0.063 13.7 1.3 4.2 7.9 0.1 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3106) Fcf1 PF04900.12 AFZ79564.1 - 3.5e-35 120.3 3.8 5e-35 119.9 3.8 1.2 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 AFZ79564.1 - 2.1e-11 44.1 0.1 3.3e-11 43.5 0.1 1.3 1 0 0 1 1 1 1 PIN like domain PilI PF10623.9 AFZ79564.1 - 0.038 14.1 0.2 0.08 13.1 0.2 1.5 1 0 0 1 1 1 0 Plasmid conjugative transfer protein PilI Imm-NTF2 PF15655.6 AFZ79564.1 - 0.068 13.5 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 NTF2 fold immunity protein MutS_IV PF05190.18 AFZ79565.1 - 0.74 10.2 4.8 4.4 7.7 0.3 2.6 2 0 0 2 2 2 0 MutS family domain IV GTP-bdg_M PF16360.5 AFZ79565.1 - 1 10.0 4.0 0.43 11.2 0.5 2.2 2 0 0 2 2 2 0 GTP-binding GTPase Middle Region DUF842 PF05811.13 AFZ79567.1 - 1.9e-24 85.8 12.8 2.9e-24 85.2 12.8 1.3 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF842) BBS2_C PF14782.6 AFZ79567.1 - 0.00035 19.5 0.1 0.00042 19.2 0.1 1.1 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, C-terminal zf-Tim10_DDP PF02953.15 AFZ79567.1 - 1.2 8.8 17.1 0.038 13.6 5.1 2.3 1 1 1 2 2 2 0 Tim10/DDP family zinc finger Histone PF00125.24 AFZ79568.1 - 2.9e-18 66.5 0.0 3.8e-18 66.1 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 AFZ79568.1 - 5.6e-12 45.2 0.1 1.1e-11 44.3 0.1 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 AFZ79568.1 - 0.0001 22.5 0.0 0.00015 22.0 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Hairpins PF04877.12 AFZ79568.1 - 0.66 9.6 4.5 0.83 9.2 4.5 1.1 1 0 0 1 1 1 0 HrpZ TRAPP PF04051.16 AFZ79570.1 - 5.7e-15 55.3 0.1 6.5e-15 55.1 0.1 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component DEAD PF00270.29 AFZ79572.1 - 2.1e-42 144.9 0.0 2.9e-42 144.4 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AFZ79572.1 - 5.2e-27 94.4 0.3 1.4e-26 93.0 0.2 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.6 AFZ79572.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit zf-RING_2 PF13639.6 AFZ79573.1 - 2.6e-13 50.1 7.8 4.4e-13 49.3 7.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 AFZ79573.1 - 3.4e-09 36.3 2.4 6.4e-09 35.4 2.4 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 AFZ79573.1 - 1.7e-08 34.1 5.1 3e-08 33.4 5.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AFZ79573.1 - 2.5e-07 30.5 4.4 4.3e-07 29.8 4.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 AFZ79573.1 - 5e-07 29.5 4.2 9.7e-07 28.6 4.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AFZ79573.1 - 5.8e-07 29.4 2.6 1.4e-06 28.2 2.6 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 AFZ79573.1 - 7.6e-07 29.3 6.7 2e-06 28.0 6.7 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 AFZ79573.1 - 0.00014 21.6 4.2 0.00026 20.8 4.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3H2C3 PF17122.5 AFZ79573.1 - 0.00017 21.5 1.1 0.00017 21.5 1.1 1.9 2 0 0 2 2 1 1 Zinc-finger Zn_ribbon_17 PF17120.5 AFZ79573.1 - 0.00035 20.1 3.4 0.00035 20.1 3.4 1.9 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 AFZ79573.1 - 0.0053 17.1 3.9 0.0097 16.2 3.9 1.5 1 0 0 1 1 1 1 RING-like domain Prok-RING_4 PF14447.6 AFZ79573.1 - 0.0063 16.4 2.7 0.014 15.2 2.7 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 AFZ79573.1 - 0.0075 16.3 1.2 0.014 15.4 1.2 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zinc_ribbon_16 PF17034.5 AFZ79573.1 - 0.025 14.8 0.7 0.049 13.9 0.7 1.5 1 0 0 1 1 1 0 Zinc-ribbon like family RINGv PF12906.7 AFZ79573.1 - 0.058 13.5 4.6 0.12 12.5 4.6 1.6 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 AFZ79573.1 - 0.092 12.9 3.4 0.24 11.6 3.4 1.7 1 0 0 1 1 1 0 FANCL C-terminal domain PHD PF00628.29 AFZ79573.1 - 0.17 11.8 4.1 0.4 10.6 4.1 1.7 1 0 0 1 1 1 0 PHD-finger zf-RING_4 PF14570.6 AFZ79573.1 - 1.1 9.1 5.8 2 8.3 5.8 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain TSP_1 PF00090.19 AFZ79574.1 - 2.8e-09 37.0 16.4 0.0017 18.6 2.1 4.7 4 0 0 4 4 4 3 Thrombospondin type 1 domain FliD_C PF07195.12 AFZ79575.1 - 0.048 13.1 0.7 0.074 12.5 0.5 1.4 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus Ssu72 PF04722.13 AFZ79575.1 - 0.081 12.5 0.3 0.11 12.1 0.3 1.2 1 0 0 1 1 1 0 Ssu72-like protein HNF_C PF09354.10 AFZ79575.1 - 0.082 14.0 0.1 0.41 11.7 0.0 2.2 2 0 0 2 2 2 0 HNF3 C-terminal domain Herpes_UL73 PF03554.13 AFZ79577.1 - 0.18 11.8 3.7 0.97 9.5 0.1 2.2 2 0 0 2 2 2 0 UL73 viral envelope glycoprotein FAINT PF04385.15 AFZ79578.1 - 1.7e-10 40.8 18.7 9.1e-05 22.4 0.2 4.4 5 0 0 5 5 5 3 Domain of unknown function, DUF529 TSP_1 PF00090.19 AFZ79579.1 - 1e-07 32.0 26.3 0.00021 21.4 6.3 4.5 3 0 0 3 3 3 3 Thrombospondin type 1 domain DnaJ_C PF01556.18 AFZ79581.1 - 1e-42 145.7 0.1 1.4e-42 145.3 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 AFZ79581.1 - 3.6e-27 94.3 1.1 7.3e-27 93.3 1.1 1.5 1 0 0 1 1 1 1 DnaJ domain ABM PF03992.16 AFZ79582.1 - 0.0029 17.7 0.5 0.0046 17.0 0.5 1.3 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase DUF3291 PF11695.8 AFZ79582.1 - 0.021 14.5 0.4 0.033 13.9 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3291) Leu_Phe_trans PF03588.14 AFZ79584.1 - 2.4e-24 85.8 0.0 3.6e-24 85.2 0.0 1.2 1 0 0 1 1 1 1 Leucyl/phenylalanyl-tRNA protein transferase NopRA1 PF16201.5 AFZ79585.1 - 1.4e-21 77.0 4.8 3.1e-20 72.6 0.6 3.4 3 0 0 3 3 3 2 Nucleolar pre-ribosomal-associated protein 1 UPF0139 PF03669.13 AFZ79585.1 - 0.1 12.5 1.0 0.66 9.9 0.5 2.7 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0139) DUF2834 PF11196.8 AFZ79585.1 - 0.74 10.2 2.6 54 4.2 0.6 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2834) s48_45 PF07422.13 AFZ79587.1 - 1.5e-20 73.8 0.7 1.2e-10 41.9 0.0 3.2 3 1 0 3 3 3 2 Sexual stage antigen s48/45 domain Ndc1_Nup PF09531.10 AFZ79589.1 - 0.13 11.0 0.7 0.17 10.5 0.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DinB PF05163.12 AFZ79589.1 - 0.3 11.0 2.3 0.57 10.1 1.6 1.8 2 0 0 2 2 2 0 DinB family SUKH_6 PF14568.6 AFZ79589.1 - 1.1 9.7 0.0 1.1 9.7 0.0 3.8 4 1 1 5 5 5 0 SMI1-KNR4 cell-wall DUF87 PF01935.17 AFZ79589.1 - 1.4 8.9 6.0 2.9 7.9 6.0 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain RP-C_C PF11800.8 AFZ79589.1 - 5.7 7.0 6.7 9.4 6.3 6.7 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region CobT PF06213.12 AFZ79589.1 - 8 5.8 15.3 13 5.1 15.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Pkinase PF00069.25 AFZ79590.1 - 2.5e-32 112.3 0.0 4.1e-32 111.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ79590.1 - 3.6e-10 39.6 0.0 6e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AFZ79590.1 - 1.5e-07 31.0 0.0 2.9e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like KH_8 PF17903.1 AFZ79591.1 - 2.7e-21 75.4 0.1 3.9e-21 74.9 0.1 1.3 1 0 0 1 1 1 1 Krr1 KH1 domain FAINT PF04385.15 AFZ79593.1 - 1.1e-07 31.7 0.1 1.6e-07 31.2 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function, DUF529 KH_1 PF00013.29 AFZ79594.1 - 2.3e-05 24.1 0.5 5.8e-05 22.8 0.5 1.7 1 0 0 1 1 1 1 KH domain KH_8 PF17903.1 AFZ79594.1 - 2.6e-05 24.2 1.4 0.00014 21.9 0.0 2.8 4 0 0 4 4 4 1 Krr1 KH1 domain KH_4 PF13083.6 AFZ79594.1 - 0.041 13.8 0.0 0.086 12.7 0.0 1.5 1 0 0 1 1 1 0 KH domain Mito_fiss_reg PF05308.11 AFZ79595.1 - 0.89 9.6 3.2 1.9 8.5 0.9 2.0 2 0 0 2 2 2 0 Mitochondrial fission regulator CAP_N PF01213.19 AFZ79595.1 - 2.7 7.4 4.2 2.2 7.7 2.3 1.7 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal DUF4690 PF15756.5 AFZ79597.1 - 0.043 14.4 0.1 0.083 13.5 0.1 1.5 1 0 0 1 1 1 0 Small Novel Rich in Cartilage FAINT PF04385.15 AFZ79598.1 - 1.5e-08 34.6 0.1 0.0061 16.6 0.2 2.7 2 0 0 2 2 2 2 Domain of unknown function, DUF529 UPF0300 PF08594.10 AFZ79598.1 - 0.09 12.1 0.1 4 6.7 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0300) FAINT PF04385.15 AFZ79599.1 - 4.3e-10 39.5 0.0 8.8e-06 25.7 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79600.1 - 2.4e-06 27.5 0.0 3.9e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function, DUF529 Cep57_CLD_2 PF14197.6 AFZ79601.1 - 0.017 15.2 1.2 0.91 9.7 0.5 2.4 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 DUF724 PF05266.14 AFZ79601.1 - 0.023 14.6 1.2 0.42 10.4 0.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Syntaxin PF00804.25 AFZ79601.1 - 0.05 13.3 6.0 0.57 9.8 5.1 2.6 1 1 0 1 1 1 0 Syntaxin CitX PF03802.14 AFZ79601.1 - 0.13 12.0 0.6 0.25 11.1 0.6 1.5 1 0 0 1 1 1 0 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase TMF_TATA_bd PF12325.8 AFZ79601.1 - 1.2 9.4 7.8 4.6 7.5 0.2 2.5 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding NPV_P10 PF05531.12 AFZ79601.1 - 1.4 9.4 4.4 9 6.9 0.2 3.1 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein BST2 PF16716.5 AFZ79601.1 - 1.5 9.4 5.2 0.46 11.1 0.8 2.3 3 0 0 3 3 3 0 Bone marrow stromal antigen 2 Ribosomal_L22 PF00237.19 AFZ79602.1 - 5.1e-14 52.4 0.2 2.4e-13 50.2 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e Na_H_Exchanger PF00999.21 AFZ79603.1 - 3.9e-31 108.2 36.8 5.1e-31 107.8 36.8 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family ProQ PF04352.13 AFZ79603.1 - 0.062 13.2 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 ProQ/FINO family SF3A2 PF16835.5 AFZ79604.1 - 1.8e-34 117.9 0.1 2.9e-34 117.3 0.1 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 AFZ79604.1 - 2.5e-06 27.7 1.3 4.4e-06 26.9 1.3 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.9 AFZ79604.1 - 0.0015 18.4 0.3 0.0023 17.9 0.3 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein DLIC PF05783.11 AFZ79604.1 - 0.015 14.2 0.0 0.021 13.6 0.0 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) GATase_5 PF13507.6 AFZ79604.1 - 0.076 12.1 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain zf-U1 PF06220.12 AFZ79604.1 - 0.16 11.8 0.3 0.29 10.9 0.3 1.4 1 0 0 1 1 1 0 U1 zinc finger Pox_EPC_I2-L1 PF12575.8 AFZ79607.1 - 0.11 12.7 0.9 0.31 11.3 0.9 1.7 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 SKG6 PF08693.10 AFZ79607.1 - 2.6 7.5 5.8 5 6.6 5.8 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain FAINT PF04385.15 AFZ79609.1 - 1e-22 80.0 20.9 1.5e-06 28.2 0.5 7.2 7 1 1 8 8 8 5 Domain of unknown function, DUF529 zf-C4_Topoisom PF01396.19 AFZ79609.1 - 0.55 10.1 2.0 2.4 8.0 0.1 2.5 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger ABC_tran PF00005.27 AFZ79610.1 - 7.6e-31 107.4 0.0 3.6e-15 56.7 0.0 2.6 2 1 0 2 2 2 2 ABC transporter AAA_29 PF13555.6 AFZ79610.1 - 5.6e-06 26.0 1.3 0.086 12.6 0.1 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 AFZ79610.1 - 1.9e-05 24.6 1.0 0.03 14.1 0.3 3.3 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 AFZ79610.1 - 6.6e-05 22.7 0.0 0.055 13.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 AFZ79610.1 - 0.00015 21.1 0.1 0.14 11.4 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin RsgA_GTPase PF03193.16 AFZ79610.1 - 0.00022 21.2 0.7 0.24 11.3 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 AFZ79610.1 - 0.00041 20.4 0.1 0.18 11.9 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 AFZ79610.1 - 0.00068 20.1 0.0 0.92 9.9 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain DnaB_C PF03796.15 AFZ79610.1 - 0.0011 18.4 0.0 0.2 11.0 0.0 2.2 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain MeaB PF03308.16 AFZ79610.1 - 0.0012 17.8 0.2 0.02 13.9 0.0 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 AFZ79610.1 - 0.0013 19.2 0.0 3.1 8.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 AFZ79610.1 - 0.002 17.9 1.4 1.6 8.3 0.1 2.4 2 0 0 2 2 2 2 AAA ATPase domain FtsK_SpoIIIE PF01580.18 AFZ79610.1 - 0.0022 17.4 0.5 0.9 8.8 0.1 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family Dynamin_N PF00350.23 AFZ79610.1 - 0.0022 18.0 0.4 0.31 11.1 0.0 2.7 2 0 0 2 2 2 1 Dynamin family SMC_N PF02463.19 AFZ79610.1 - 0.0034 16.8 2.2 0.052 13.0 0.3 2.6 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 AFZ79610.1 - 0.0036 17.6 0.0 0.79 10.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 AFZ79610.1 - 0.0062 16.6 2.7 0.2 11.7 0.0 2.7 3 0 0 3 3 3 1 Helicase HerA, central domain AAA_23 PF13476.6 AFZ79610.1 - 0.0092 16.5 8.9 0.48 10.9 1.1 2.5 3 0 0 3 3 2 2 AAA domain AAA_27 PF13514.6 AFZ79610.1 - 0.03 13.9 0.1 6.1 6.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 AFZ79610.1 - 0.032 14.5 0.0 0.067 13.4 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit T2SSE PF00437.20 AFZ79610.1 - 0.034 13.2 0.8 2.8 6.9 0.1 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein TrwB_AAD_bind PF10412.9 AFZ79610.1 - 0.034 13.1 0.1 5.1 5.9 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain NB-ARC PF00931.22 AFZ79610.1 - 0.042 13.0 0.3 0.64 9.2 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain SRP54 PF00448.22 AFZ79610.1 - 0.043 13.5 0.1 1.6 8.3 0.0 2.6 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain ATPase_2 PF01637.18 AFZ79610.1 - 0.048 13.6 0.0 8.8 6.2 0.0 2.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea ATP_bind_1 PF03029.17 AFZ79610.1 - 0.051 13.4 0.1 3.7 7.3 0.0 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein cobW PF02492.19 AFZ79610.1 - 0.052 13.1 0.1 7.3 6.1 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 AFZ79610.1 - 0.06 13.7 0.0 14 6.1 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA_7 PF12775.7 AFZ79610.1 - 0.065 12.7 0.4 14 5.2 0.0 2.8 3 0 0 3 3 2 0 P-loop containing dynein motor region NTPase_1 PF03266.15 AFZ79610.1 - 0.1 12.5 0.1 15 5.4 0.1 2.4 2 0 0 2 2 2 0 NTPase NACHT PF05729.12 AFZ79610.1 - 0.11 12.4 0.1 13 5.7 0.1 2.5 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.6 AFZ79610.1 - 0.11 12.1 0.1 2.5 7.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain FAINT PF04385.15 AFZ79611.1 - 3e-09 36.8 6.8 0.0022 18.0 0.0 4.5 4 1 1 5 5 5 2 Domain of unknown function, DUF529 DUF4348 PF14254.6 AFZ79611.1 - 0.21 10.9 1.2 3.8 6.8 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4348) DnaJ PF00226.31 AFZ79612.1 - 9.2e-21 73.8 1.2 2.2e-20 72.5 1.2 1.7 1 0 0 1 1 1 1 DnaJ domain Thioredoxin PF00085.20 AFZ79612.1 - 6.1e-08 32.6 0.1 1.8e-07 31.1 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin NTP_transferase PF00483.23 AFZ79613.1 - 3e-47 161.3 0.0 3.7e-47 161.0 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 AFZ79613.1 - 8.1e-11 41.2 12.8 3.4e-06 26.6 3.2 3.7 2 1 1 3 3 3 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 AFZ79613.1 - 9.3e-11 42.3 0.0 1.2e-10 42.0 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.12 AFZ79613.1 - 0.0075 15.2 0.2 0.016 14.2 0.1 1.6 2 0 0 2 2 2 1 L-fucokinase Hexapep_2 PF14602.6 AFZ79613.1 - 1 9.2 11.4 0.32 10.8 2.7 3.4 3 1 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase UQ_con PF00179.26 AFZ79614.1 - 1.4e-22 79.8 0.1 1.9e-22 79.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 AFZ79614.1 - 0.0027 17.4 0.0 0.0036 17.0 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B Prok-E2_E PF14462.6 AFZ79614.1 - 0.022 14.6 0.0 0.036 13.9 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family E UEV PF05743.13 AFZ79614.1 - 0.098 12.5 0.2 0.18 11.6 0.1 1.6 1 1 1 2 2 2 0 UEV domain RWD PF05773.22 AFZ79614.1 - 0.11 12.8 0.1 0.12 12.6 0.1 1.3 1 0 0 1 1 1 0 RWD domain Xylo_C PF12529.8 AFZ79615.1 - 0.03 14.0 0.0 0.056 13.1 0.0 1.4 1 0 0 1 1 1 0 Xylosyltransferase C terminal MACPF PF01823.19 AFZ79616.1 - 6.4e-20 72.2 0.4 8.2e-20 71.8 0.4 1.1 1 0 0 1 1 1 1 MAC/Perforin domain Ntox6 PF15544.6 AFZ79616.1 - 0.036 13.6 0.1 0.046 13.3 0.1 1.1 1 0 0 1 1 1 0 Bacterial toxin 6 Adap_comp_sub PF00928.21 AFZ79617.1 - 4.8e-53 180.2 0.1 6.5e-53 179.8 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 AFZ79617.1 - 2.2e-05 24.4 0.0 3.5e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 AFZ79617.1 - 0.029 13.8 0.0 0.049 13.1 0.0 1.3 1 0 0 1 1 1 0 Muniscin C-terminal mu homology domain CD34_antigen PF06365.12 AFZ79618.1 - 0.0041 16.7 0.2 0.0095 15.5 0.2 1.6 1 0 0 1 1 1 1 CD34/Podocalyxin family DUF1279 PF06916.13 AFZ79621.1 - 1.6e-10 41.4 1.3 2.6e-10 40.7 0.5 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1279) MHC_II_beta PF00969.19 AFZ79621.1 - 0.09 12.9 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 Class II histocompatibility antigen, beta domain PPR_2 PF13041.6 AFZ79622.1 - 0.033 14.4 0.0 0.27 11.5 0.0 2.2 2 0 0 2 2 2 0 PPR repeat family GHMP_kinases_N PF00288.26 AFZ79623.1 - 1.8e-05 24.9 1.6 2.9e-05 24.2 0.2 2.0 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 AFZ79623.1 - 0.095 13.1 0.0 0.3 11.5 0.0 1.8 2 0 0 2 2 2 0 GHMP kinases C terminal Hydrolase_4 PF12146.8 AFZ79624.1 - 2.4e-16 59.8 0.0 3.7e-15 55.8 0.0 2.4 2 1 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 AFZ79624.1 - 2.5e-13 49.9 14.2 4.9e-07 29.7 0.3 4.0 3 1 0 3 3 3 3 Domain of unknown function, DUF529 Abhydrolase_1 PF00561.20 AFZ79624.1 - 0.0049 16.5 0.2 0.071 12.7 0.1 2.6 2 1 0 2 2 2 1 alpha/beta hydrolase fold FAINT PF04385.15 AFZ79625.1 - 1.7e-11 44.0 0.0 0.027 14.5 0.0 3.4 3 0 0 3 3 3 3 Domain of unknown function, DUF529 TypeIII_RM_meth PF12564.8 AFZ79625.1 - 0.045 13.9 0.5 0.84 9.8 0.1 2.7 2 0 0 2 2 2 0 Type III restriction/modification enzyme methylation subunit AAA_22 PF13401.6 AFZ79626.1 - 8.5e-10 39.0 0.1 3e-09 37.3 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AFZ79626.1 - 1.8e-09 38.2 0.0 6.6e-09 36.4 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain ATPase_2 PF01637.18 AFZ79626.1 - 1.5e-07 31.6 0.3 3.8e-07 30.3 0.3 1.7 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA PF00004.29 AFZ79626.1 - 9.7e-07 29.3 0.2 3.6e-06 27.4 0.2 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 AFZ79626.1 - 0.0002 21.7 0.0 0.00053 20.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 AFZ79626.1 - 0.00023 20.4 0.0 0.00052 19.2 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein TniB PF05621.11 AFZ79626.1 - 0.00023 20.7 0.0 0.00097 18.6 0.0 1.9 1 1 0 1 1 1 1 Bacterial TniB protein AAA_7 PF12775.7 AFZ79626.1 - 0.0073 15.8 0.0 0.019 14.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region PIF1 PF05970.14 AFZ79626.1 - 0.0081 15.4 0.4 0.02 14.1 0.0 1.8 2 0 0 2 2 2 1 PIF1-like helicase ORC4_C PF14629.6 AFZ79626.1 - 0.0088 15.4 0.6 0.027 13.8 0.6 1.8 1 1 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_14 PF13173.6 AFZ79626.1 - 0.01 15.8 0.8 0.22 11.6 0.6 2.7 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 AFZ79626.1 - 0.012 15.3 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 AFZ79626.1 - 0.018 14.2 0.0 0.034 13.3 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain PEPCK_ATP PF01293.20 AFZ79626.1 - 0.023 13.4 0.1 0.041 12.5 0.1 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase Bac_DnaA PF00308.18 AFZ79626.1 - 0.045 13.6 0.2 0.9 9.3 0.0 2.6 2 0 0 2 2 2 0 Bacterial dnaA protein DUF2075 PF09848.9 AFZ79626.1 - 0.053 12.7 0.2 0.15 11.2 0.1 1.7 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 AFZ79626.1 - 0.061 13.2 0.5 0.31 10.9 0.5 2.2 1 1 0 1 1 1 0 NACHT domain AAA_32 PF13654.6 AFZ79626.1 - 0.068 11.9 0.0 0.12 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain ISP3_C PF18045.1 AFZ79626.1 - 0.077 12.9 1.5 13 5.7 0.1 2.6 2 0 0 2 2 2 0 ISP3 C-terminal AAA_24 PF13479.6 AFZ79626.1 - 0.085 12.6 0.1 0.17 11.6 0.1 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 AFZ79626.1 - 0.13 12.6 0.5 3.2 8.2 0.0 3.0 3 0 0 3 3 3 0 RNA helicase CSTF2_hinge PF14327.6 AFZ79626.1 - 0.14 12.6 3.2 0.11 12.9 0.6 2.1 2 0 0 2 2 2 0 Hinge domain of cleavage stimulation factor subunit 2 Ribosomal_L28 PF00830.19 AFZ79627.1 - 1e-13 51.2 2.6 1e-13 51.2 2.6 2.4 4 0 0 4 4 4 1 Ribosomal L28 family ATP-synt_A PF00119.20 AFZ79628.1 - 0.00043 20.3 0.5 0.00046 20.2 0.5 1.0 1 0 0 1 1 1 1 ATP synthase A chain SIT PF15330.6 AFZ79628.1 - 0.11 13.0 0.3 0.11 13.0 0.3 2.0 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT eIF-5_eIF-2B PF01873.17 AFZ79629.1 - 2.2e-35 121.0 0.0 3.9e-35 120.2 0.0 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 zf-RanBP PF00641.18 AFZ79629.1 - 0.06 12.7 1.8 4.4 6.7 0.1 2.4 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others PKI PF02827.16 AFZ79629.1 - 0.37 11.0 2.0 0.39 11.0 1.0 1.5 1 1 0 1 1 1 0 cAMP-dependent protein kinase inhibitor DFRP_C PF16543.5 AFZ79630.1 - 4.2e-14 52.8 5.2 4.2e-14 52.8 5.2 3.4 2 1 0 3 3 3 1 DRG Family Regulatory Proteins, Tma46 CAF1 PF04857.20 AFZ79631.1 - 5.5e-74 249.2 1.7 7.5e-74 248.8 1.7 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease RNA_bind PF08675.11 AFZ79631.1 - 9.1e-08 32.0 1.3 2.4e-07 30.7 1.3 1.7 1 0 0 1 1 1 1 RNA binding domain DNA_pol_A_exo1 PF01612.20 AFZ79631.1 - 3.6e-05 23.6 0.4 0.27 10.9 0.0 3.4 3 0 0 3 3 3 2 3'-5' exonuclease GCP_N_terminal PF17681.1 AFZ79632.1 - 4.3e-31 108.7 1.2 5e-31 108.5 0.2 1.7 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal DUF713 PF05218.14 AFZ79632.1 - 0.16 11.7 3.5 0.4 10.4 3.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF713) Sugar_tr PF00083.24 AFZ79633.1 - 5.2e-07 28.9 15.7 1.5e-06 27.4 15.7 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter DUF5408 PF17402.2 AFZ79633.1 - 0.25 11.3 0.0 0.25 11.3 0.0 3.6 4 1 1 5 5 5 0 Family of unknown function (DUF5408) MFS_1 PF07690.16 AFZ79634.1 - 5.6e-12 45.2 16.6 8.9e-12 44.6 16.6 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 AFZ79635.1 - 4.1e-11 42.4 9.2 4.1e-11 42.4 9.2 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily PX PF00787.24 AFZ79636.1 - 5.9e-07 29.5 0.2 1.3e-06 28.4 0.2 1.5 1 0 0 1 1 1 1 PX domain WD40 PF00400.32 AFZ79636.1 - 1.2e-05 26.0 0.5 0.063 14.2 0.1 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat eIF-3c_N PF05470.12 AFZ79636.1 - 0.069 11.5 0.0 0.1 10.9 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus ANAPC4_WD40 PF12894.7 AFZ79636.1 - 0.11 12.9 0.0 14 6.1 0.0 3.3 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain CAF1C_H4-bd PF12265.8 AFZ79637.1 - 9.2e-13 48.3 0.1 2.9e-12 46.7 0.0 1.9 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 AFZ79637.1 - 1.6e-07 31.9 20.4 0.027 15.3 1.2 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AFZ79637.1 - 3.9e-07 30.3 0.4 0.0013 19.0 0.2 3.9 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AFZ79637.1 - 9.8e-05 22.3 0.1 0.017 15.0 0.0 3.2 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A VPS9 PF02204.18 AFZ79638.1 - 3.7e-29 101.0 1.1 7.4e-28 96.8 0.2 2.5 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain Acyltransferase PF01553.21 AFZ79639.1 - 2.8e-14 52.9 0.0 4.3e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase zf-CDGSH PF09360.10 AFZ79640.1 - 6.6e-16 58.3 6.4 1.8e-10 40.9 0.8 2.2 2 0 0 2 2 2 2 Iron-binding zinc finger CDGSH type GcpE PF04551.14 AFZ79641.1 - 3.8e-152 506.4 0.2 5.4e-152 505.9 0.2 1.2 1 0 0 1 1 1 1 GcpE protein Citrate_synt PF00285.21 AFZ79642.1 - 1.4e-85 287.6 0.0 1.9e-85 287.1 0.0 1.2 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Flavoprotein PF02441.19 AFZ79643.1 - 1.7e-40 138.3 0.0 3.2e-40 137.4 0.0 1.5 1 0 0 1 1 1 1 Flavoprotein Snf7 PF03357.21 AFZ79643.1 - 1.2e-15 57.6 21.3 2.5e-15 56.5 21.3 1.6 1 1 0 1 1 1 1 Snf7 ArAE_1_C PF11728.8 AFZ79643.1 - 0.24 11.4 10.0 0.49 10.4 10.0 1.5 1 0 0 1 1 1 0 Putative aromatic acid exporter C-terminal domain Pkinase PF00069.25 AFZ79644.1 - 9.6e-55 185.8 0.1 9e-44 149.8 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ79644.1 - 2.3e-30 105.8 0.0 1.4e-23 83.5 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase FTA2 PF13095.6 AFZ79644.1 - 8.5e-05 22.3 0.3 0.083 12.5 0.0 2.6 3 0 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 AFZ79644.1 - 0.0003 19.7 0.0 0.00047 19.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 AFZ79644.1 - 0.012 14.9 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 AFZ79644.1 - 0.12 11.7 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WD40 PF00400.32 AFZ79645.1 - 5e-12 46.1 1.7 0.056 14.3 0.0 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AFZ79645.1 - 2.4e-07 31.0 0.9 0.04 14.2 0.1 4.5 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 AFZ79645.1 - 1.9e-05 24.3 0.3 0.01 15.5 0.0 3.0 2 1 0 3 3 3 1 PQQ-like domain CPSF_A PF03178.15 AFZ79645.1 - 0.0069 15.7 0.2 2.6 7.2 0.0 3.1 2 1 1 3 3 3 2 CPSF A subunit region WD40_like PF17005.5 AFZ79645.1 - 0.026 13.9 0.1 2 7.7 0.0 2.2 1 1 1 2 2 2 0 WD40-like domain WD40 PF00400.32 AFZ79646.1 - 5.7e-28 96.6 17.5 0.00048 20.9 0.0 9.8 9 0 0 9 9 9 6 WD domain, G-beta repeat Utp13 PF08625.11 AFZ79646.1 - 3.3e-17 62.7 0.3 6.6e-17 61.7 0.0 1.7 2 0 0 2 2 2 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 AFZ79646.1 - 2.9e-10 40.3 2.3 3.4 8.0 0.0 7.0 4 2 3 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 AFZ79646.1 - 0.00015 21.8 0.6 0.014 15.4 0.0 3.7 3 1 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 AFZ79646.1 - 0.00039 19.8 11.5 0.0038 16.6 1.8 4.8 4 1 1 5 5 5 2 WD40-like domain WD40 PF00400.32 AFZ79647.1 - 2.7e-15 56.5 7.1 0.0035 18.2 0.4 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AFZ79647.1 - 3.9e-08 33.5 0.0 0.0014 18.9 0.0 4.4 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 AFZ79647.1 - 0.056 12.0 0.0 0.089 11.3 0.0 1.2 1 0 0 1 1 1 0 Cytochrome D1 heme domain NBD_C PF17042.5 AFZ79647.1 - 0.22 12.0 0.0 0.64 10.5 0.0 1.8 1 0 0 1 1 1 0 Nucleotide-binding C-terminal domain Hydrolase_4 PF12146.8 AFZ79650.1 - 5.1e-22 78.3 0.0 1.3e-19 70.4 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 AFZ79650.1 - 5.7e-22 78.6 0.1 1e-13 51.5 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AFZ79650.1 - 6.4e-11 43.3 0.0 4.6e-10 40.5 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.13 AFZ79650.1 - 1.3e-05 25.0 0.0 0.0016 18.2 0.0 3.0 2 1 0 2 2 2 1 Serine hydrolase (FSH1) Abhydrolase_4 PF08386.10 AFZ79650.1 - 0.00068 19.7 0.0 0.0013 18.8 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein Peptidase_S9 PF00326.21 AFZ79650.1 - 0.0011 18.5 0.0 0.58 9.6 0.0 2.4 2 0 0 2 2 2 2 Prolyl oligopeptidase family BAAT_C PF08840.11 AFZ79650.1 - 0.0025 17.7 0.0 0.094 12.6 0.0 2.2 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal LIDHydrolase PF10230.9 AFZ79650.1 - 0.0029 17.2 0.0 0.048 13.2 0.0 2.1 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase DLH PF01738.18 AFZ79650.1 - 0.02 14.5 0.0 0.56 9.7 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Palm_thioest PF02089.15 AFZ79650.1 - 0.021 14.6 0.0 0.21 11.4 0.0 2.1 1 1 0 1 1 1 0 Palmitoyl protein thioesterase Abhydrolase_3 PF07859.13 AFZ79650.1 - 0.038 13.9 0.0 1.1 9.1 0.0 2.3 2 0 0 2 2 2 0 alpha/beta hydrolase fold Esterase PF00756.20 AFZ79650.1 - 0.13 11.9 0.0 0.93 9.1 0.0 2.2 2 1 0 2 2 2 0 Putative esterase Ndr PF03096.14 AFZ79650.1 - 0.18 10.5 0.0 0.45 9.2 0.0 1.6 1 1 0 1 1 1 0 Ndr family Ribosomal_L27 PF01016.19 AFZ79651.1 - 3.7e-10 39.7 0.2 2.8e-09 36.8 0.2 2.0 1 1 0 1 1 1 1 Ribosomal L27 protein FPL PF09758.9 AFZ79652.1 - 3e-48 163.6 0.7 8e-48 162.2 0.7 1.8 1 0 0 1 1 1 1 Uncharacterised conserved protein DUF3395 PF11875.8 AFZ79653.1 - 2.1e-21 76.5 0.1 3.5e-21 75.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 AFZ79653.1 - 8e-18 64.3 0.9 1.9e-17 63.1 0.9 1.7 1 0 0 1 1 1 1 DnaJ domain Kinesin PF00225.23 AFZ79654.1 - 1.4e-78 264.2 0.4 2.1e-78 263.6 0.4 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 AFZ79654.1 - 5.9e-14 52.2 0.1 1.4e-13 51.0 0.1 1.7 1 0 0 1 1 1 1 Microtubule binding CPL PF08144.11 AFZ79655.1 - 7.6e-07 29.6 15.0 2.3e-06 28.0 0.5 4.4 3 2 0 4 4 4 2 CPL (NUC119) domain YcgL PF05166.13 AFZ79655.1 - 0.09 13.1 0.2 1.8 9.0 0.0 2.7 2 0 0 2 2 2 0 YcgL domain Tmemb_170 PF10190.9 AFZ79656.1 - 0.012 15.9 1.3 0.012 15.9 1.3 3.9 3 1 1 4 4 4 0 Putative transmembrane protein 170 TatD_DNase PF01026.21 AFZ79657.1 - 1.9e-47 161.8 0.0 3.3e-47 161.0 0.0 1.4 1 1 0 1 1 1 1 TatD related DNase MSG PF02349.15 AFZ79657.1 - 0.055 13.7 2.1 0.14 12.3 2.1 1.8 1 0 0 1 1 1 0 Major surface glycoprotein Vac14_Fig4_bd PF11916.8 AFZ79660.1 - 8.8e-44 149.3 3.3 8.8e-44 149.3 3.3 2.0 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 AFZ79660.1 - 3.2e-35 120.6 5.2 1.4e-31 108.9 0.5 3.6 3 0 0 3 3 3 2 Vacuolar 14 Fab1-binding region HEAT PF02985.22 AFZ79660.1 - 0.00025 21.0 0.1 0.87 10.0 0.0 4.2 4 0 0 4 4 4 1 HEAT repeat HEAT_EZ PF13513.6 AFZ79660.1 - 0.0025 18.3 0.0 0.69 10.5 0.0 3.7 4 0 0 4 4 4 1 HEAT-like repeat DUF3819 PF12842.7 AFZ79660.1 - 0.032 14.2 0.1 0.11 12.4 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3819) ThiF PF00899.21 AFZ79661.1 - 5.4e-98 327.2 0.0 3e-66 223.3 0.0 2.2 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 AFZ79661.1 - 1.5e-59 201.9 0.1 2.2e-59 201.4 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 AFZ79661.1 - 7.4e-23 80.5 0.4 2.2e-22 79.0 0.4 1.9 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_UFD PF09358.10 AFZ79661.1 - 2e-20 73.3 0.0 1.2e-19 70.8 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin fold domain E1_4HB PF16191.5 AFZ79661.1 - 6.8e-05 23.0 0.0 0.00016 21.8 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle Pyr_redox PF00070.27 AFZ79661.1 - 0.014 15.9 0.3 1.3 9.7 0.0 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 AFZ79661.1 - 0.027 13.7 0.0 0.26 10.5 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 AFZ79661.1 - 0.039 14.0 0.2 16 5.6 0.0 2.7 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 AFZ79661.1 - 0.14 11.5 0.3 18 4.7 0.0 2.4 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UPF0203 PF05254.12 AFZ79663.1 - 3.7e-15 55.9 5.8 4.4e-15 55.7 5.8 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) COX17 PF05051.13 AFZ79663.1 - 0.0034 17.7 2.6 0.011 16.1 2.5 1.7 1 1 1 2 2 2 2 Cytochrome C oxidase copper chaperone (COX17) UCR_hinge PF02320.16 AFZ79663.1 - 0.016 15.4 2.5 0.038 14.2 2.5 1.7 1 1 0 1 1 1 0 Ubiquinol-cytochrome C reductase hinge protein Cmc1 PF08583.10 AFZ79663.1 - 0.029 14.4 4.8 0.08 13.0 4.8 1.7 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like zinc-ribbons_6 PF07191.12 AFZ79663.1 - 0.046 13.7 1.0 0.073 13.1 1.0 1.4 1 1 0 1 1 1 0 zinc-ribbons FANCL_C PF11793.8 AFZ79663.1 - 0.091 12.9 3.2 2.5 8.3 0.6 2.1 1 1 1 2 2 2 0 FANCL C-terminal domain NDUF_B7 PF05676.13 AFZ79663.1 - 0.81 9.5 5.5 7.8 6.3 0.6 2.1 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) ADK PF00406.22 AFZ79664.1 - 3.9e-31 108.2 0.0 4.6e-31 107.9 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 AFZ79664.1 - 6.9e-28 97.8 0.0 8.9e-28 97.4 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AFZ79664.1 - 2.3e-12 47.6 0.0 3.6e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 AFZ79664.1 - 1.5e-09 38.2 0.0 3.6e-09 36.9 0.0 1.6 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 AFZ79664.1 - 5.5e-06 25.8 0.0 1.8e-05 24.1 0.0 1.7 1 1 0 1 1 1 1 Zeta toxin Ploopntkinase3 PF18751.1 AFZ79664.1 - 0.00031 20.7 0.0 0.00062 19.7 0.0 1.6 2 0 0 2 2 2 1 P-loop Nucleotide Kinase3 NB-ARC PF00931.22 AFZ79664.1 - 0.00034 19.9 0.1 0.00061 19.1 0.1 1.4 1 0 0 1 1 1 1 NB-ARC domain dNK PF01712.19 AFZ79664.1 - 0.00062 19.7 0.0 1.1 9.0 0.0 2.1 2 0 0 2 2 2 2 Deoxynucleoside kinase AAA_22 PF13401.6 AFZ79664.1 - 0.00069 19.9 0.0 0.001 19.3 0.0 1.5 1 1 0 1 1 1 1 AAA domain CPT PF07931.12 AFZ79664.1 - 0.00093 19.1 0.0 0.0012 18.7 0.0 1.1 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_5 PF07728.14 AFZ79664.1 - 0.011 15.8 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 AFZ79664.1 - 0.012 16.0 0.0 0.018 15.4 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 AFZ79664.1 - 0.014 15.5 0.0 0.038 14.1 0.0 1.8 2 0 0 2 2 1 0 50S ribosome-binding GTPase Viral_helicase1 PF01443.18 AFZ79664.1 - 0.02 14.6 0.0 0.03 14.1 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Cytidylate_kin PF02224.18 AFZ79664.1 - 0.024 14.4 0.2 0.11 12.2 0.0 1.9 2 0 0 2 2 2 0 Cytidylate kinase ABC_tran PF00005.27 AFZ79664.1 - 0.029 14.9 0.0 0.054 14.0 0.0 1.5 2 0 0 2 2 1 0 ABC transporter KTI12 PF08433.10 AFZ79664.1 - 0.044 13.2 0.2 0.1 12.0 0.1 1.9 1 1 1 2 2 2 0 Chromatin associated protein KTI12 AAA_14 PF13173.6 AFZ79664.1 - 0.049 13.7 0.0 0.1 12.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain MeaB PF03308.16 AFZ79664.1 - 0.061 12.3 0.1 0.13 11.2 0.0 1.6 1 1 1 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA PF00004.29 AFZ79664.1 - 0.064 13.7 0.0 0.19 12.1 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 AFZ79664.1 - 0.068 12.9 0.2 0.16 11.8 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain TsaE PF02367.17 AFZ79664.1 - 0.076 13.0 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 AFZ79664.1 - 0.077 12.9 0.0 0.13 12.2 0.0 1.6 1 1 0 1 1 1 0 NTPase AAA_28 PF13521.6 AFZ79664.1 - 0.08 13.2 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 AFZ79664.1 - 0.082 12.8 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase RNA_helicase PF00910.22 AFZ79664.1 - 0.082 13.3 0.0 0.22 11.9 0.0 1.8 2 0 0 2 2 1 0 RNA helicase ATPase_2 PF01637.18 AFZ79664.1 - 0.088 12.7 0.0 0.15 11.9 0.0 1.6 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea 6PF2K PF01591.18 AFZ79664.1 - 0.093 12.0 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase NACHT PF05729.12 AFZ79664.1 - 0.1 12.5 0.0 0.23 11.4 0.0 1.8 1 1 0 1 1 1 0 NACHT domain Mg_chelatase PF01078.21 AFZ79664.1 - 0.12 11.8 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATP_bind_1 PF03029.17 AFZ79664.1 - 0.14 11.9 0.0 0.3 10.8 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Thymidylate_kin PF02223.17 AFZ79664.1 - 0.15 11.8 0.0 4.1 7.0 0.0 2.1 2 0 0 2 2 2 0 Thymidylate kinase APS_kinase PF01583.20 AFZ79664.1 - 0.16 11.9 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase Roc PF08477.13 AFZ79664.1 - 0.17 12.1 0.0 1.6 9.0 0.0 2.3 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase FAINT PF04385.15 AFZ79665.1 - 2.4e-08 33.9 0.1 3.6e-08 33.4 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function, DUF529 RabGAP-TBC PF00566.18 AFZ79666.1 - 5.3e-49 166.8 0.1 1e-48 165.9 0.1 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Fez1 PF06818.15 AFZ79667.1 - 0.0097 16.4 5.8 0.016 15.6 5.8 1.3 1 0 0 1 1 1 1 Fez1 FTA4 PF13093.6 AFZ79667.1 - 0.021 14.7 2.7 0.033 14.1 2.7 1.4 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Membralin PF09746.9 AFZ79667.1 - 0.11 11.5 2.7 0.14 11.2 2.7 1.1 1 0 0 1 1 1 0 Tumour-associated protein DUF641 PF04859.12 AFZ79667.1 - 0.19 12.1 6.9 0.25 11.7 0.3 2.3 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Mvb12 PF09452.10 AFZ79667.1 - 0.22 12.0 1.9 30 5.1 0.0 2.7 1 1 2 3 3 3 0 ESCRT-I subunit Mvb12 V-SNARE PF05008.15 AFZ79667.1 - 1.7 9.1 8.2 3.3 8.1 5.3 2.8 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus CLZ PF16526.5 AFZ79667.1 - 4.2 7.8 8.3 0.59 10.5 2.7 2.5 3 1 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels MAM PF00629.23 AFZ79669.1 - 0.045 13.7 0.4 0.31 10.9 0.0 2.3 2 1 0 2 2 2 0 MAM domain, meprin/A5/mu Fez1 PF06818.15 AFZ79671.1 - 0.016 15.7 12.9 0.016 15.7 12.9 3.3 1 1 2 3 3 3 0 Fez1 DUF2937 PF11157.8 AFZ79671.1 - 1.7 8.4 4.4 1.5 8.5 1.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) Spc7 PF08317.11 AFZ79671.1 - 3.6 6.4 44.4 0.74 8.6 1.4 3.2 1 1 2 3 3 3 0 Spc7 kinetochore protein Pox_A_type_inc PF04508.12 AFZ79671.1 - 4.7 7.2 12.5 8.2 6.5 2.9 4.4 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat DUF3629 PF12302.8 AFZ79671.1 - 4.8 6.6 11.3 0.43 10.0 3.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3629) Pkinase PF00069.25 AFZ79672.1 - 1.2e-61 208.4 0.0 1.9e-61 207.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ79672.1 - 8.1e-27 94.1 0.0 1.3e-26 93.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.6 AFZ79672.1 - 3e-11 43.6 0.4 0.00052 20.4 0.3 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 AFZ79672.1 - 3.1e-11 42.0 2.6 2.6e-05 23.5 0.1 3.8 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 AFZ79672.1 - 8.3e-10 38.4 0.4 0.00055 19.7 0.4 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 AFZ79672.1 - 3.3e-09 35.9 2.2 0.022 14.6 0.1 3.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 AFZ79672.1 - 0.00054 19.3 0.3 0.94 9.1 0.3 2.7 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.7 AFZ79672.1 - 0.021 14.7 0.6 14 5.7 0.0 2.9 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand APH PF01636.23 AFZ79672.1 - 0.023 14.6 0.1 0.046 13.6 0.1 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Prismane PF03063.20 AFZ79672.1 - 0.12 11.1 0.0 0.18 10.5 0.0 1.2 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family EF-hand_10 PF14788.6 AFZ79672.1 - 0.13 12.1 0.2 0.35 10.8 0.2 1.7 1 0 0 1 1 1 0 EF hand BCAS2 PF05700.11 AFZ79673.1 - 9.6e-25 87.5 2.1 1.4e-24 87.0 2.1 1.2 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) UPF0121 PF03661.13 AFZ79674.1 - 1e-12 48.0 6.4 1.4e-12 47.6 6.4 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) DUF2177 PF09945.9 AFZ79674.1 - 0.33 11.0 1.7 0.37 10.9 0.1 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2177) LSM PF01423.22 AFZ79675.1 - 3.4e-16 58.7 0.5 4.1e-16 58.4 0.5 1.0 1 0 0 1 1 1 1 LSM domain Sec23_trunk PF04811.15 AFZ79676.1 - 9.9e-59 198.8 0.0 1.5e-58 198.3 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 AFZ79676.1 - 1e-28 99.9 0.5 2.2e-28 98.9 0.5 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 AFZ79676.1 - 8.7e-21 73.7 0.3 1.8e-20 72.6 0.3 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 AFZ79676.1 - 2e-12 46.9 2.0 2e-12 46.9 2.0 2.0 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 AFZ79676.1 - 5.4e-12 45.4 0.1 1.4e-11 44.2 0.1 1.7 1 0 0 1 1 1 1 Gelsolin repeat VWA_2 PF13519.6 AFZ79676.1 - 0.054 14.1 0.0 2.5 8.8 0.0 2.9 2 1 2 4 4 4 0 von Willebrand factor type A domain DUF3347 PF11827.8 AFZ79679.1 - 0.62 10.2 2.7 1.1 9.4 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) USP8_dimer PF08969.11 AFZ79679.1 - 0.72 10.1 3.2 1.7 8.9 3.2 1.5 1 0 0 1 1 1 0 USP8 dimerisation domain FAINT PF04385.15 AFZ79680.1 - 1.5e-15 57.0 16.3 8.9e-07 28.9 4.1 3.5 3 0 0 3 3 3 3 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79681.1 - 2.6e-11 43.4 5.4 1.5e-05 25.0 2.0 3.7 3 0 0 3 3 3 3 Domain of unknown function, DUF529 Tnp_22_trimer PF17489.2 AFZ79681.1 - 0.2 11.6 0.1 0.2 11.6 0.1 2.1 2 0 0 2 2 2 0 L1 transposable element trimerization domain WIYLD PF10440.9 AFZ79681.1 - 2 8.3 5.9 39 4.1 0.0 3.5 3 0 0 3 3 3 0 Ubiquitin-binding WIYLD domain Actin PF00022.19 AFZ79682.1 - 2.1e-82 277.0 0.0 1.4e-81 274.3 0.0 2.1 1 1 0 1 1 1 1 Actin PP-binding PF00550.25 AFZ79683.1 - 4.4e-09 36.6 0.2 5.8e-09 36.2 0.2 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 AFZ79683.1 - 0.0044 17.2 1.5 0.031 14.5 0.5 2.0 1 1 1 2 2 2 1 Acyl-carrier DUF3734 PF12536.8 AFZ79683.1 - 0.16 12.3 0.0 0.22 11.9 0.0 1.2 1 0 0 1 1 1 0 Patatin phospholipase NGP1NT PF08153.12 AFZ79684.1 - 2.6e-34 118.2 1.3 5.2e-34 117.2 1.3 1.4 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 AFZ79684.1 - 5e-16 58.8 0.2 1e-13 51.3 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AFZ79684.1 - 3.2e-06 26.8 0.0 0.0002 21.0 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 AFZ79684.1 - 0.00012 22.0 0.0 0.00039 20.4 0.0 1.9 1 1 0 1 1 1 1 RsgA GTPase Arf PF00025.21 AFZ79684.1 - 0.00076 19.0 0.0 0.81 9.1 0.0 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Dynamin_N PF00350.23 AFZ79684.1 - 0.0012 18.9 0.9 1 9.4 0.0 3.3 2 1 1 3 3 3 1 Dynamin family GTP_EFTU PF00009.27 AFZ79684.1 - 0.0048 16.5 0.8 0.56 9.7 0.2 2.9 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain SusD-like_3 PF14322.6 AFZ79684.1 - 0.06 13.7 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 Starch-binding associating with outer membrane SHS2_Rpb7-N PF03876.17 AFZ79686.1 - 1.8e-07 31.4 0.0 3.3e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RPA43_OB PF17875.1 AFZ79686.1 - 0.0091 16.6 0.0 0.016 15.8 0.0 1.5 1 0 0 1 1 1 1 RPA43 OB domain in RNA Pol I RRF PF01765.19 AFZ79688.1 - 1e-23 84.1 5.1 1e-23 84.1 5.1 2.0 1 1 1 2 2 2 1 Ribosome recycling factor HU-CCDC81_bac_1 PF18174.1 AFZ79688.1 - 0.011 15.5 0.1 0.046 13.6 0.0 2.1 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 1 RasGAP_C PF03836.15 AFZ79688.1 - 0.91 9.7 7.7 0.17 12.0 0.4 2.2 2 0 0 2 2 2 0 RasGAP C-terminus ALMT PF11744.8 AFZ79688.1 - 1.8 7.3 5.6 1.8 7.3 4.9 1.5 1 1 0 1 1 1 0 Aluminium activated malate transporter CRAL_TRIO_2 PF13716.6 AFZ79689.1 - 1.2e-07 32.0 0.1 1e-06 28.9 0.0 2.2 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain Macro PF01661.21 AFZ79689.1 - 8.2e-06 25.8 0.1 2.2e-05 24.5 0.1 1.7 1 0 0 1 1 1 1 Macro domain RasGEF_N PF00618.20 AFZ79689.1 - 0.022 15.0 0.3 2.3 8.5 0.2 2.5 2 1 0 2 2 2 0 RasGEF N-terminal motif DUF866 PF05907.13 AFZ79690.1 - 2.5e-27 95.7 0.4 3e-27 95.4 0.4 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) IP_trans PF02121.18 AFZ79691.1 - 4.2e-55 187.0 0.4 7.1e-55 186.3 0.4 1.4 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein PH PF00169.29 AFZ79691.1 - 1.5e-11 44.7 0.1 5.4e-11 42.9 0.1 2.0 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 AFZ79691.1 - 0.001 19.4 0.0 0.0029 17.9 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain EF-hand_1 PF00036.32 AFZ79692.1 - 4e-40 132.4 9.6 8.1e-10 37.6 0.4 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 AFZ79692.1 - 1e-34 118.8 1.4 5.4e-17 62.0 0.6 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 AFZ79692.1 - 7.7e-33 112.1 9.1 2.2e-15 56.2 0.4 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 AFZ79692.1 - 1.5e-30 102.4 6.9 2.3e-09 36.4 0.2 4.4 4 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 AFZ79692.1 - 4.4e-29 98.7 8.5 6.7e-07 28.5 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 AFZ79692.1 - 7.5e-14 51.8 0.0 4.3e-08 33.4 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 AFZ79692.1 - 8.1e-09 35.4 0.5 0.00035 20.5 0.1 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 AFZ79692.1 - 5.1e-08 33.2 0.1 0.0017 18.6 0.0 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 AFZ79692.1 - 3e-07 31.3 0.0 0.00015 22.6 0.0 2.1 1 1 1 2 2 2 2 EF-hand domain Dockerin_1 PF00404.18 AFZ79692.1 - 1.3e-06 28.5 1.0 0.005 17.0 0.3 2.8 2 2 1 3 3 3 2 Dockerin type I domain UPF0154 PF03672.13 AFZ79692.1 - 4.4e-06 26.6 0.0 0.022 14.7 0.0 2.6 3 0 0 3 3 2 2 Uncharacterised protein family (UPF0154) Caleosin PF05042.13 AFZ79692.1 - 0.0013 18.7 0.2 1 9.2 0.0 2.9 1 1 1 3 3 3 1 Caleosin related protein DUF3349 PF11829.8 AFZ79692.1 - 0.002 18.9 0.2 0.78 10.6 0.0 2.6 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) EFhand_Ca_insen PF08726.10 AFZ79692.1 - 0.0042 17.1 0.5 0.021 14.9 0.1 2.3 2 2 0 2 2 2 1 Ca2+ insensitive EF hand RNA_pol_Rpb4 PF03874.16 AFZ79692.1 - 0.0046 17.3 0.3 2.9 8.2 0.0 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb4 TerB PF05099.13 AFZ79692.1 - 0.0079 16.2 0.1 2.2 8.3 0.0 2.4 1 1 1 2 2 2 1 Tellurite resistance protein TerB Fe_hyd_lg_C PF02906.14 AFZ79692.1 - 0.024 14.3 0.4 0.069 12.8 0.4 1.7 1 1 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain MotA_activ PF09114.10 AFZ79692.1 - 0.036 14.2 0.1 0.79 9.9 0.0 2.2 2 0 0 2 2 2 0 Transcription factor MotA, activation domain DUF5580 PF17743.1 AFZ79692.1 - 0.037 12.6 0.0 0.037 12.6 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) DUF853 PF05872.12 AFZ79692.1 - 0.039 12.6 0.1 1.1 7.8 0.0 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF853) DUF1811 PF08838.10 AFZ79692.1 - 0.066 13.5 0.1 14 6.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1811) DUF1456 PF07308.13 AFZ79692.1 - 0.072 13.4 0.1 4.7 7.6 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1456) SapB_1 PF05184.15 AFZ79692.1 - 0.23 11.5 0.5 40 4.3 0.0 3.1 3 0 0 3 3 3 0 Saposin-like type B, region 1 FAINT PF04385.15 AFZ79694.1 - 1.1e-10 41.4 2.8 0.00021 21.3 0.8 2.6 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79695.1 - 0.0015 18.5 0.0 0.0026 17.8 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function, DUF529 STIMATE PF12400.8 AFZ79696.1 - 1.4e-18 67.7 13.7 7e-15 55.7 2.8 2.9 4 0 0 4 4 4 2 STIMATE family Ribosomal_L22 PF00237.19 AFZ79697.1 - 3.7e-37 126.7 0.0 5.1e-37 126.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e V-ATPase_H_C PF11698.8 AFZ79698.1 - 0.3 11.2 3.7 2.2 8.4 0.2 3.3 3 1 0 3 3 3 0 V-ATPase subunit H FAINT PF04385.15 AFZ79699.1 - 0.052 13.6 0.3 0.15 12.2 0.1 2.0 2 1 0 2 2 2 0 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79700.1 - 6e-14 51.9 0.2 1.2e-06 28.4 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 GATA PF00320.27 AFZ79700.1 - 0.025 14.2 0.0 0.057 13.0 0.0 1.6 1 0 0 1 1 1 0 GATA zinc finger FAINT PF04385.15 AFZ79701.1 - 6.1e-19 67.9 14.0 4e-09 36.4 0.5 3.8 3 1 0 3 3 3 3 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79704.1 - 0.0087 16.1 0.0 0.021 14.9 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function, DUF529 SPW PF03779.14 AFZ79705.1 - 2.4 7.8 4.6 2.9 7.6 0.8 2.2 2 0 0 2 2 2 0 SPW repeat IMCp PF12314.8 AFZ79706.1 - 3.1e-21 75.4 54.9 1.6e-20 73.2 38.6 5.5 1 1 3 5 5 5 2 Inner membrane complex protein FGGY_N PF00370.21 AFZ79707.1 - 8.7e-50 169.6 0.1 1.4e-49 168.9 0.1 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 AFZ79707.1 - 6.9e-44 149.9 0.0 1.3e-43 149.0 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Pex14_N PF04695.13 AFZ79708.1 - 0.077 13.6 0.4 0.19 12.4 0.4 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Pkinase PF00069.25 AFZ79710.1 - 7.1e-62 209.2 0.0 1.7e-61 207.9 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ79710.1 - 2.5e-33 115.5 0.0 6.2e-33 114.2 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 AFZ79710.1 - 0.00011 21.6 0.0 0.00017 21.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 AFZ79710.1 - 0.0024 17.8 0.0 0.0042 17.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 AFZ79710.1 - 0.026 13.5 0.6 0.35 9.8 0.0 2.0 1 1 0 2 2 2 0 Haspin like kinase domain FAINT PF04385.15 AFZ79711.1 - 0.00011 22.2 0.0 0.031 14.3 0.0 2.8 2 1 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79712.1 - 8.6e-09 35.3 0.2 0.00018 21.5 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 DUF3437 PF11919.8 AFZ79712.1 - 0.091 12.7 0.3 0.17 11.8 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) FAINT PF04385.15 AFZ79713.1 - 5.5e-11 42.4 0.1 0.00046 20.2 0.0 2.9 2 1 2 4 4 4 2 Domain of unknown function, DUF529 ALS2CR11 PF15729.5 AFZ79713.1 - 0.031 13.4 0.6 0.052 12.7 0.6 1.3 1 0 0 1 1 1 0 Amyotrophic lateral sclerosis 2 candidate 11 DUF4362 PF14275.6 AFZ79713.1 - 0.05 13.9 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4362) TrpBP PF02081.15 AFZ79713.1 - 0.11 12.3 0.3 1.4 8.8 0.1 2.3 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein FAINT PF04385.15 AFZ79714.1 - 3e-09 36.8 3.1 1.8e-05 24.7 0.3 2.7 3 0 0 3 3 3 2 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79715.1 - 0.06 13.4 1.4 0.13 12.3 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79716.1 - 0.0086 16.1 0.0 0.016 15.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 DEAD PF00270.29 AFZ79717.1 - 4.4e-50 169.9 0.0 6.4e-50 169.3 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AFZ79717.1 - 1.1e-28 99.7 0.1 8e-28 97.0 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 AFZ79717.1 - 4.6e-09 36.5 0.1 1.1e-08 35.3 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 AFZ79717.1 - 5.6e-05 22.5 0.0 9e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_22 PF13401.6 AFZ79717.1 - 0.024 14.9 0.4 0.21 11.9 0.2 2.6 3 1 0 3 3 3 0 AAA domain DUF4287 PF14117.6 AFZ79717.1 - 0.11 12.7 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4287) Flavi_DEAD PF07652.14 AFZ79717.1 - 0.14 12.1 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain LSM PF01423.22 AFZ79718.1 - 9.9e-12 44.4 0.2 2.7e-09 36.6 0.0 2.7 2 0 0 2 2 2 2 LSM domain FHIPEP PF00771.20 AFZ79718.1 - 0.028 12.9 0.6 0.054 12.0 0.6 1.4 1 0 0 1 1 1 0 FHIPEP family BNR_2 PF13088.6 AFZ79718.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 BNR repeat-like domain VSP PF03302.13 AFZ79719.1 - 0.23 10.3 0.1 0.35 9.7 0.1 1.2 1 0 0 1 1 1 0 Giardia variant-specific surface protein zf-C3H2C3 PF17122.5 AFZ79720.1 - 1.6e-06 28.0 12.7 3.8e-06 26.8 12.7 1.7 1 0 0 1 1 1 1 Zinc-finger DIX PF00778.17 AFZ79720.1 - 0.041 13.7 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 DIX domain VPS11_C PF12451.8 AFZ79720.1 - 0.045 14.0 0.9 0.11 12.8 0.9 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting protein 11 C terminal zf-C3HC4_2 PF13923.6 AFZ79720.1 - 1.1 9.2 8.8 2.5 8.0 8.8 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TPR_11 PF13414.6 AFZ79720.1 - 8.7 6.1 6.2 0.7 9.6 0.3 2.3 3 0 0 3 3 3 0 TPR repeat Hydrolase_4 PF12146.8 AFZ79722.1 - 1.7e-24 86.4 0.0 1.5e-23 83.3 0.0 2.4 2 1 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 AFZ79722.1 - 1.9e-10 40.6 0.0 0.026 14.6 0.0 3.8 3 0 0 3 3 3 3 Domain of unknown function, DUF529 Abhydrolase_1 PF00561.20 AFZ79722.1 - 9.4e-06 25.4 1.1 4.2e-05 23.3 1.0 2.1 1 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AFZ79722.1 - 5.6e-05 23.8 0.0 0.00011 22.9 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 AFZ79722.1 - 0.00036 20.5 0.0 0.0047 16.8 0.0 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 AFZ79722.1 - 0.0097 15.4 0.2 0.5 9.8 0.0 2.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family DUF900 PF05990.12 AFZ79722.1 - 0.11 11.9 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) FAINT PF04385.15 AFZ79723.1 - 1.5e-09 37.8 0.0 0.054 13.6 0.0 3.3 3 0 0 3 3 3 3 Domain of unknown function, DUF529 XPG_N PF00752.17 AFZ79724.1 - 4.6e-07 30.2 0.2 8.7e-07 29.4 0.0 1.5 2 0 0 2 2 2 1 XPG N-terminal domain BatD PF13584.6 AFZ79725.1 - 0.084 11.7 0.0 0.3 9.8 0.0 1.8 2 0 0 2 2 2 0 Oxygen tolerance Glucos_trans_II PF14264.6 AFZ79725.1 - 0.17 11.2 6.8 0.26 10.6 6.8 1.1 1 0 0 1 1 1 0 Glucosyl transferase GtrII TMEM154 PF15102.6 AFZ79725.1 - 0.44 10.5 0.0 0.44 10.5 0.0 1.9 2 0 0 2 2 2 0 TMEM154 protein family DUF2142 PF09913.9 AFZ79725.1 - 0.45 9.3 2.1 0.69 8.7 2.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2142) DUF3290 PF11694.8 AFZ79725.1 - 0.66 9.9 8.7 0.75 9.8 6.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) DUF4131 PF13567.6 AFZ79725.1 - 6.9 6.3 6.5 16 5.1 6.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) FAINT PF04385.15 AFZ79726.1 - 2e-15 56.6 12.2 1.6e-05 24.8 0.4 4.6 3 3 2 5 5 5 3 Domain of unknown function, DUF529 Glyco_hydro_32N PF00251.20 AFZ79726.1 - 0.0067 16.0 0.1 0.0094 15.6 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain DUF2510 PF10708.9 AFZ79726.1 - 0.13 12.1 0.1 0.33 10.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2510) Sugar_tr PF00083.24 AFZ79727.1 - 2.1e-61 208.2 31.8 2.6e-61 207.9 31.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AFZ79727.1 - 5.8e-12 45.2 34.1 5.4e-08 32.2 12.0 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 AFZ79727.1 - 5.5e-05 21.8 2.2 5.5e-05 21.8 2.2 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) CYYR1 PF10873.8 AFZ79727.1 - 0.92 9.9 7.1 0.1 13.0 1.6 2.2 2 1 0 2 2 2 0 Cysteine and tyrosine-rich protein 1 FAINT PF04385.15 AFZ79728.1 - 1.6e-14 53.7 0.0 8.9e-09 35.3 0.1 2.5 2 0 0 2 2 2 2 Domain of unknown function, DUF529 DUF4988 PF16378.5 AFZ79728.1 - 0.0053 16.4 0.1 0.0091 15.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function Hydrolase_3 PF08282.12 AFZ79729.1 - 2.3e-27 96.3 0.0 2.6e-26 92.9 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AFZ79729.1 - 0.0029 17.9 0.0 0.0051 17.1 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase FAINT PF04385.15 AFZ79729.1 - 0.0035 17.4 1.3 0.013 15.5 0.3 2.7 3 0 0 3 3 3 1 Domain of unknown function, DUF529 S6PP PF05116.13 AFZ79729.1 - 0.007 15.9 0.0 0.013 15.0 0.0 1.4 1 0 0 1 1 1 1 Sucrose-6F-phosphate phosphohydrolase FAINT PF04385.15 AFZ79731.1 - 1.4e-15 57.1 1.0 1.2e-07 31.7 0.3 2.3 2 0 0 2 2 2 2 Domain of unknown function, DUF529 IF4E PF01652.18 AFZ79733.1 - 2.4e-30 105.4 0.1 3.3e-30 105.0 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E FAINT PF04385.15 AFZ79735.1 - 5.1e-05 23.3 2.4 0.0051 16.8 0.4 2.5 2 0 0 2 2 2 2 Domain of unknown function, DUF529 EMA PF02488.15 AFZ79735.1 - 0.003 17.3 2.9 0.18 11.5 0.1 2.6 2 1 1 3 3 3 2 Merozoite Antigen RRM_9 PF18444.1 AFZ79735.1 - 0.14 12.0 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif DUF3977 PF13122.6 AFZ79736.1 - 0.075 13.3 0.1 0.18 12.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3977) TetM_leader PF08076.11 AFZ79736.1 - 0.24 11.2 1.1 1.5 8.7 0.0 2.8 3 0 0 3 3 3 0 Tetracycline resistance determinant leader peptide RVT_1 PF00078.27 AFZ79737.1 - 3.4e-35 121.6 0.1 5.8e-35 120.8 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Tn7_Tnp_TnsA_N PF08722.11 AFZ79738.1 - 0.11 12.7 2.2 2.5 8.3 2.2 2.4 1 1 0 1 1 1 0 TnsA endonuclease N terminal FAINT PF04385.15 AFZ79740.1 - 0.00051 20.1 0.2 0.0012 18.8 0.1 1.7 1 1 1 2 2 2 1 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79741.1 - 0.0018 18.3 0.1 0.0058 16.7 0.0 1.9 1 1 1 2 2 2 1 Domain of unknown function, DUF529 Ank_4 PF13637.6 AFZ79742.1 - 8.8e-25 86.8 3.3 8.3e-12 45.4 0.1 3.4 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 AFZ79742.1 - 2.4e-21 76.1 0.3 1.9e-12 47.6 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 AFZ79742.1 - 1.7e-17 63.0 1.2 0.00016 22.0 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 AFZ79742.1 - 2.7e-17 62.6 0.1 1.8e-05 24.9 0.0 4.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 AFZ79742.1 - 4.9e-17 60.3 0.6 0.0046 17.4 0.0 4.5 4 0 0 4 4 4 4 Ankyrin repeat FAINT PF04385.15 AFZ79744.1 - 1.3e-21 76.4 21.3 6.9e-10 38.8 3.6 5.1 4 1 0 4 4 4 4 Domain of unknown function, DUF529 Hydrolase_4 PF12146.8 AFZ79745.1 - 2.7e-21 75.9 0.0 9.2e-20 70.9 0.0 2.7 2 1 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 AFZ79745.1 - 3e-15 56.0 4.8 9.1e-07 28.9 0.0 4.1 4 0 0 4 4 4 3 Domain of unknown function, DUF529 Abhydrolase_1 PF00561.20 AFZ79745.1 - 3.9e-05 23.4 0.5 0.00015 21.5 0.4 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AFZ79745.1 - 0.0018 18.9 0.0 0.0039 17.8 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 AFZ79745.1 - 0.099 12.4 0.1 2.7 7.8 0.0 2.7 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase FAINT PF04385.15 AFZ79747.1 - 5e-41 138.6 41.8 3.5e-06 27.0 0.3 11.4 11 0 0 11 11 11 9 Domain of unknown function, DUF529 FAD_binding_9 PF08021.11 AFZ79747.1 - 0.049 13.8 0.0 1.8 8.8 0.0 3.2 3 0 0 3 3 3 0 Siderophore-interacting FAD-binding domain GLE1 PF07817.13 AFZ79748.1 - 0.038 13.2 0.0 0.039 13.2 0.0 1.1 1 0 0 1 1 1 0 GLE1-like protein Ysc84 PF04366.12 AFZ79749.1 - 0.0053 16.5 0.0 0.0061 16.3 0.0 1.0 1 0 0 1 1 1 1 Las17-binding protein actin regulator FAINT PF04385.15 AFZ79750.1 - 0.11 12.5 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function, DUF529 Hydrolase_3 PF08282.12 AFZ79752.1 - 2.3e-39 135.7 0.0 2.6e-39 135.5 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 AFZ79752.1 - 6.4e-06 25.9 0.0 0.015 14.9 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 AFZ79752.1 - 7.2e-05 23.2 0.0 0.00096 19.5 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 AFZ79752.1 - 0.00094 19.3 0.0 0.0076 16.3 0.0 2.2 3 0 0 3 3 3 1 Haloacid dehalogenase-like hydrolase Acid_phosphat_B PF03767.14 AFZ79752.1 - 0.03 13.9 0.0 1.3 8.6 0.0 2.4 2 1 0 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) Hydrolase_6 PF13344.6 AFZ79752.1 - 0.041 14.0 0.0 0.074 13.2 0.0 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase HAD PF12710.7 AFZ79752.1 - 0.09 13.2 0.0 0.32 11.4 0.0 1.9 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase FAINT PF04385.15 AFZ79754.1 - 6e-06 26.2 0.0 1e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 EMA PF02488.15 AFZ79754.1 - 0.026 14.2 0.1 0.029 14.0 0.1 1.1 1 0 0 1 1 1 0 Merozoite Antigen DUF4028 PF13220.6 AFZ79755.1 - 0.34 10.7 4.6 2.2 8.1 0.3 3.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4028) FAINT PF04385.15 AFZ79756.1 - 1.2e-06 28.5 0.6 0.058 13.5 0.2 2.6 2 1 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79757.1 - 6.7e-13 48.5 0.0 2.5e-05 24.2 0.0 3.7 3 0 0 3 3 3 3 Domain of unknown function, DUF529 ABC_membrane PF00664.23 AFZ79758.1 - 2.1e-35 122.7 10.1 2.9e-35 122.3 10.1 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 AFZ79758.1 - 2.2e-35 122.2 0.0 4.4e-35 121.2 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 AFZ79758.1 - 3.9e-09 36.3 0.6 4.6e-07 29.5 0.6 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain NTPase_1 PF03266.15 AFZ79758.1 - 4.5e-06 26.7 1.0 0.00088 19.2 1.0 2.3 1 1 0 1 1 1 1 NTPase DEAD PF00270.29 AFZ79758.1 - 8.1e-05 22.5 0.2 0.0002 21.2 0.2 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA PF00004.29 AFZ79758.1 - 0.00015 22.2 0.3 0.0034 17.8 0.3 2.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 AFZ79758.1 - 0.00029 21.1 0.2 0.0024 18.1 0.2 2.5 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 AFZ79758.1 - 0.00093 19.8 0.7 0.0019 18.7 0.7 1.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AFZ79758.1 - 0.0012 19.3 0.0 0.003 18.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AFZ79758.1 - 0.0036 17.7 0.1 0.0099 16.3 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain DUF87 PF01935.17 AFZ79758.1 - 0.0041 17.3 0.1 0.011 15.8 0.1 1.7 1 0 0 1 1 1 1 Helicase HerA, central domain AAA_30 PF13604.6 AFZ79758.1 - 0.012 15.4 0.0 0.027 14.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 AFZ79758.1 - 0.022 14.8 0.0 0.24 11.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 AFZ79758.1 - 0.024 14.4 0.4 0.089 12.6 0.1 2.1 2 0 0 2 2 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 AFZ79758.1 - 0.026 14.6 0.5 0.063 13.4 0.1 1.9 2 0 0 2 2 1 0 50S ribosome-binding GTPase AAA_19 PF13245.6 AFZ79758.1 - 0.026 14.9 0.0 0.061 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 AFZ79758.1 - 0.046 13.9 0.1 1.3 9.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 AFZ79758.1 - 0.05 13.1 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region YebG PF07130.12 AFZ79758.1 - 0.052 13.4 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 YebG protein TMEM132D_C PF15706.5 AFZ79758.1 - 0.058 13.2 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term RNA_helicase PF00910.22 AFZ79758.1 - 0.069 13.6 0.0 0.69 10.3 0.0 2.3 2 0 0 2 2 2 0 RNA helicase IstB_IS21 PF01695.17 AFZ79758.1 - 0.078 12.7 0.1 0.28 10.9 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein Cytidylate_kin PF02224.18 AFZ79758.1 - 0.078 12.7 0.1 0.15 11.8 0.1 1.4 1 0 0 1 1 1 0 Cytidylate kinase T2SSE PF00437.20 AFZ79758.1 - 0.088 11.9 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein TsaE PF02367.17 AFZ79758.1 - 0.09 12.8 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ResIII PF04851.15 AFZ79758.1 - 0.096 12.7 0.1 0.25 11.3 0.0 1.8 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit FAINT PF04385.15 AFZ79760.1 - 0.00057 19.9 0.1 0.001 19.1 0.1 1.5 1 1 0 1 1 1 1 Domain of unknown function, DUF529 WD40 PF00400.32 AFZ79761.1 - 2.2e-26 91.6 17.6 3.2e-05 24.6 0.0 8.9 9 0 0 9 9 9 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AFZ79761.1 - 8e-11 42.1 0.3 0.15 12.4 0.0 5.8 4 1 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AFZ79761.1 - 0.00049 18.9 2.5 3.2 6.3 0.0 4.9 4 1 0 4 4 4 1 Nucleoporin Nup120/160 Utp12 PF04003.12 AFZ79761.1 - 0.044 14.1 0.2 0.1 12.9 0.2 1.6 1 0 0 1 1 1 0 Dip2/Utp12 Family Lactonase PF10282.9 AFZ79761.1 - 0.065 12.5 0.0 0.23 10.7 0.0 1.9 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller Ge1_WD40 PF16529.5 AFZ79761.1 - 0.26 10.2 9.0 8.7 5.2 0.0 4.9 5 1 1 6 6 6 0 WD40 region of Ge1, enhancer of mRNA-decapping protein AAA_23 PF13476.6 AFZ79762.1 - 0.07 13.6 3.7 0.048 14.2 0.5 2.1 2 0 0 2 2 2 0 AAA domain FlaF PF07309.11 AFZ79762.1 - 0.11 12.5 0.9 0.29 11.2 0.9 1.6 1 0 0 1 1 1 0 Flagellar protein FlaF FTA4 PF13093.6 AFZ79762.1 - 1.7 8.5 6.5 3.5 7.5 6.3 1.7 1 1 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Cytochrom_B562 PF07361.11 AFZ79763.1 - 0.13 12.9 11.8 0.11 13.1 0.5 4.0 2 1 2 4 4 4 0 Cytochrome b562 ERM PF00769.19 AFZ79763.1 - 3.6 7.3 32.4 0.039 13.8 24.3 1.8 2 1 0 2 2 2 0 Ezrin/radixin/moesin family AAA_27 PF13514.6 AFZ79764.1 - 0.035 13.7 1.6 0.064 12.8 1.6 1.3 1 0 0 1 1 1 0 AAA domain PG_binding_4 PF12229.8 AFZ79765.1 - 0.0075 16.5 0.2 0.029 14.7 0.0 1.9 2 0 0 2 2 2 1 Putative peptidoglycan binding domain PIG-H PF10181.9 AFZ79766.1 - 7.4e-12 45.0 1.6 6.6e-11 41.9 0.3 2.2 2 0 0 2 2 2 2 GPI-GlcNAc transferase complex, PIG-H component FAINT PF04385.15 AFZ79770.1 - 1.9e-27 95.1 6.8 2.9e-05 24.0 0.3 5.7 5 0 0 5 5 5 5 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79771.1 - 8.3e-20 70.6 18.2 9.6e-07 28.8 0.3 4.3 4 0 0 4 4 4 3 Domain of unknown function, DUF529 TANGO2 PF05742.12 AFZ79771.1 - 0.042 13.9 0.0 0.095 12.7 0.0 1.5 1 0 0 1 1 1 0 Transport and Golgi organisation 2 Glycos_transf_2 PF00535.26 AFZ79772.1 - 4e-23 82.1 0.0 8.1e-23 81.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 AFZ79772.1 - 1.1e-06 28.3 0.0 1.9e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 AFZ79772.1 - 1.4e-06 28.3 0.0 2.5e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 AFZ79772.1 - 0.047 13.2 0.0 0.085 12.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 OTU PF02338.19 AFZ79773.1 - 1.1e-23 84.1 0.5 1.1e-23 84.1 0.5 2.0 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 AFZ79773.1 - 1.5e-05 24.5 0.3 0.0051 16.3 0.0 2.5 1 1 1 2 2 2 2 Peptidase C65 Otubain SBE2 PF17076.5 AFZ79773.1 - 0.014 13.6 0.9 0.019 13.2 0.9 1.1 1 0 0 1 1 1 0 SBE2, cell-wall formation TetR_C_24 PF17932.1 AFZ79773.1 - 0.3 11.4 2.8 5.1 7.4 0.5 2.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain GPS2_interact PF15784.5 AFZ79773.1 - 0.37 11.3 3.8 0.6 10.6 3.8 1.3 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain EELM2 PF15863.5 AFZ79774.1 - 1.9e-71 239.7 2.7 1.9e-71 239.7 2.7 1.8 2 0 0 2 2 2 1 Extended EGL-27 and MTA1 homology domain PHD PF00628.29 AFZ79774.1 - 3e-06 27.0 6.7 7.4e-06 25.8 6.7 1.6 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H_2 PF13832.6 AFZ79774.1 - 0.00043 20.4 1.6 0.00097 19.3 1.6 1.6 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 AFZ79774.1 - 0.0027 17.9 0.6 0.0077 16.5 0.6 1.7 1 0 0 1 1 1 1 PHD-like zinc-binding domain PHD_2 PF13831.6 AFZ79774.1 - 0.0051 16.3 1.3 0.0051 16.3 1.3 1.9 2 0 0 2 2 2 1 PHD-finger zf-PHD-like PF15446.6 AFZ79774.1 - 0.0072 16.0 1.6 0.0072 16.0 1.6 1.9 1 1 0 1 1 1 1 PHD/FYVE-zinc-finger like domain zf-RING-like PF08746.11 AFZ79774.1 - 0.017 15.4 4.1 0.038 14.3 4.1 1.6 1 0 0 1 1 1 0 RING-like domain C1_1 PF00130.22 AFZ79774.1 - 0.072 13.0 9.3 0.054 13.4 3.0 2.6 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_9 PF13901.6 AFZ79774.1 - 0.13 12.2 2.5 0.1 12.5 0.6 1.8 1 1 0 1 1 1 0 Putative zinc-RING and/or ribbon zf-RING_2 PF13639.6 AFZ79774.1 - 0.39 11.1 5.0 0.93 9.9 5.0 1.7 1 0 0 1 1 1 0 Ring finger domain PTPRCAP PF15713.5 AFZ79774.1 - 0.45 10.8 6.2 1.6 9.0 0.0 2.2 1 1 1 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Methyltransf_16 PF10294.9 AFZ79775.1 - 1.9e-26 92.9 0.0 4.2e-26 91.7 0.0 1.5 1 0 0 1 1 1 1 Lysine methyltransferase Ank_2 PF12796.7 AFZ79775.1 - 4.1e-12 46.5 0.2 1.1e-10 41.9 0.2 2.5 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 AFZ79775.1 - 9.2e-10 38.6 0.4 4.7e-05 23.6 0.2 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 AFZ79775.1 - 3.5e-06 27.4 0.1 0.0013 19.3 0.1 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 AFZ79775.1 - 6.2e-06 26.2 0.0 0.003 17.9 0.0 3.7 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 AFZ79775.1 - 0.00018 21.8 0.0 0.0067 16.8 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat MTS PF05175.14 AFZ79775.1 - 0.018 14.6 0.0 0.039 13.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain UPF0561 PF10573.9 AFZ79775.1 - 0.06 13.5 2.0 0.14 12.2 2.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 HALZ PF02183.18 AFZ79778.1 - 0.016 15.4 2.7 0.016 15.4 2.7 2.3 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF4407 PF14362.6 AFZ79778.1 - 0.58 9.5 4.4 0.47 9.8 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Fungal_TACC PF12709.7 AFZ79778.1 - 0.6 10.6 6.0 0.28 11.6 2.0 2.6 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins DUF4618 PF15397.6 AFZ79778.1 - 1.7 8.0 8.7 0.36 10.2 0.4 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4618) DivIC PF04977.15 AFZ79778.1 - 2.4 8.0 9.2 0.058 13.2 1.1 2.5 2 0 0 2 2 2 0 Septum formation initiator DUF4600 PF15372.6 AFZ79779.1 - 0.003 18.0 2.9 0.0054 17.2 2.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4600) zf-C4H2 PF10146.9 AFZ79779.1 - 0.89 9.8 4.9 1.1 9.5 4.9 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein FeoB_associated PF12669.7 AFZ79781.1 - 0.1 13.0 0.5 0.41 11.1 0.5 2.0 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein DUF2637 PF10935.8 AFZ79781.1 - 0.55 10.1 5.3 0.48 10.3 1.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2637) tRNA-synt_2 PF00152.20 AFZ79783.1 - 8.6e-77 258.3 0.0 1.5e-76 257.5 0.0 1.4 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AFZ79783.1 - 6.6e-07 29.2 0.0 1.3e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 AFZ79783.1 - 0.0053 16.3 0.1 0.042 13.3 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) GAF PF01590.26 AFZ79786.1 - 3.9e-14 53.4 0.3 3.3e-10 40.7 0.2 2.7 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.6 AFZ79786.1 - 2.2e-11 44.2 0.0 4e-09 36.9 0.1 2.3 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.6 AFZ79786.1 - 4.1e-06 27.2 0.0 7.7e-05 23.0 0.0 2.5 2 1 0 2 2 2 1 GAF domain CPSF_A PF03178.15 AFZ79787.1 - 2e-20 73.3 0.4 6.3e-15 55.3 0.0 3.6 5 0 0 5 5 5 2 CPSF A subunit region MMS1_N PF10433.9 AFZ79787.1 - 0.0004 19.2 0.1 0.0014 17.4 0.1 1.9 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Band_3_cyto PF07565.13 AFZ79787.1 - 0.41 10.4 5.5 0.32 10.8 3.6 1.8 1 1 0 1 1 1 0 Band 3 cytoplasmic domain DUF2691 PF10903.8 AFZ79788.1 - 0.1 12.5 0.3 0.19 11.6 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2691) FAINT PF04385.15 AFZ79790.1 - 7e-13 48.4 5.8 0.002 18.1 0.0 5.9 5 1 0 5 5 5 4 Domain of unknown function, DUF529 eRF1_2 PF03464.15 AFZ79791.1 - 1.2e-45 155.0 0.0 2e-45 154.4 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 AFZ79791.1 - 2.4e-33 115.0 0.2 5e-33 114.0 0.2 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 AFZ79791.1 - 1e-21 77.3 0.0 1.7e-21 76.6 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 baeRF_family10 PF18854.1 AFZ79791.1 - 2.4e-09 37.5 0.1 1.1e-08 35.4 0.0 1.9 2 0 0 2 2 2 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 AFZ79791.1 - 2.3e-08 34.4 0.0 3.5e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor DUF5643 PF18705.1 AFZ79791.1 - 0.047 13.7 0.5 0.42 10.6 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5643) Ribosomal_L7Ae PF01248.26 AFZ79791.1 - 0.12 12.2 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family HSP70 PF00012.20 AFZ79794.1 - 1.5e-266 885.4 10.1 1.7e-266 885.2 10.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AFZ79794.1 - 6.5e-18 64.6 3.3 1.1e-16 60.6 0.6 2.3 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 AFZ79794.1 - 3.7e-05 23.5 0.0 0.00012 21.8 0.0 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 AFZ79794.1 - 0.0089 16.4 4.8 1.3 9.5 0.1 3.5 3 2 0 3 3 3 2 Cell division protein FtsA NLE PF08154.12 AFZ79794.1 - 0.16 12.5 0.0 0.43 11.1 0.0 1.7 1 0 0 1 1 1 0 NLE (NUC135) domain CBM65_1 PF18259.1 AFZ79795.1 - 0.016 15.4 0.0 0.072 13.2 0.0 2.0 2 0 0 2 2 2 0 Carbohydrate binding module 65 domain 1 Tom37 PF10568.9 AFZ79796.1 - 0.082 13.2 2.2 0.19 12.0 2.2 1.7 1 1 0 1 1 1 0 Outer mitochondrial membrane transport complex protein Ribosomal_S14 PF00253.21 AFZ79797.1 - 0.0023 17.7 0.9 0.0023 17.7 0.9 2.2 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e SepZ PF06066.11 AFZ79797.1 - 0.018 15.2 0.0 0.034 14.4 0.0 1.4 1 0 0 1 1 1 0 SepZ Ferlin_C PF16165.5 AFZ79798.1 - 0.31 11.0 3.6 0.84 9.6 3.6 1.7 1 0 0 1 1 1 0 Ferlin C-terminus tRNA-synt_1c PF00749.21 AFZ79798.1 - 2.5 6.9 7.1 4.9 5.9 7.1 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain MMR1 PF08505.10 AFZ79798.1 - 9.6 6.4 10.7 0.41 10.9 4.9 1.6 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein Ribosomal_S13_N PF08069.12 AFZ79799.1 - 0.046 13.8 0.3 9.1 6.4 0.0 2.4 2 0 0 2 2 2 0 Ribosomal S13/S15 N-terminal domain FAINT PF04385.15 AFZ79800.1 - 2.2e-14 53.3 0.6 1.2e-05 25.3 0.0 4.1 4 0 0 4 4 4 3 Domain of unknown function, DUF529 2-Hacid_dh_C PF02826.19 AFZ79800.1 - 0.079 12.3 0.0 2.2 7.6 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAINT PF04385.15 AFZ79802.1 - 1.9e-05 24.6 0.9 3.4e-05 23.8 0.5 1.6 2 0 0 2 2 2 1 Domain of unknown function, DUF529 Kinesin_assoc PF16183.5 AFZ79802.1 - 0.021 15.0 0.0 0.023 14.8 0.0 1.2 1 0 0 1 1 1 0 Kinesin-associated FAINT PF04385.15 AFZ79803.1 - 0.13 12.3 10.7 0.76 9.9 0.6 3.6 2 1 1 3 3 3 0 Domain of unknown function, DUF529 Cys_rich_CPXG PF14255.6 AFZ79804.1 - 0.79 9.7 4.5 4.2 7.4 0.5 2.7 2 0 0 2 2 2 0 Cysteine-rich CPXCG FAINT PF04385.15 AFZ79805.1 - 4.2e-08 33.1 5.3 0.042 13.9 0.1 3.7 3 0 0 3 3 3 3 Domain of unknown function, DUF529 DUF573 PF04504.14 AFZ79805.1 - 0.07 13.8 0.5 0.23 12.1 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF573 RXT2_N PF08595.11 AFZ79806.1 - 0.09 12.8 7.3 0.36 10.9 7.3 2.0 1 0 0 1 1 1 0 RXT2-like, N-terminal NOA36 PF06524.12 AFZ79806.1 - 0.19 11.0 10.4 0.31 10.3 10.4 1.3 1 0 0 1 1 1 0 NOA36 protein FAINT PF04385.15 AFZ79808.1 - 1.4e-50 169.2 35.4 7.9e-06 25.9 0.0 10.6 10 0 0 10 10 10 10 Domain of unknown function, DUF529 ANAPC4_WD40 PF12894.7 AFZ79811.1 - 0.084 13.2 0.0 1.2 9.5 0.0 2.2 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AFZ79811.1 - 0.17 12.8 2.2 27 5.8 0.0 3.7 4 0 0 4 4 4 0 WD domain, G-beta repeat MliC PF09864.9 AFZ79812.1 - 0.058 13.4 0.0 2.1 8.3 0.0 2.8 2 1 0 2 2 2 0 Membrane-bound lysozyme-inhibitor of c-type lysozyme FAINT PF04385.15 AFZ79813.1 - 0.00029 20.8 0.0 0.00054 20.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79814.1 - 2.3e-05 24.3 0.0 4.3e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 RNA_pol_A_bac PF01000.26 AFZ79819.1 - 4.5e-23 81.7 0.0 9.6e-23 80.7 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 AFZ79819.1 - 1.7e-17 62.6 0.0 2.2e-17 62.2 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Fer4_9 PF13187.6 AFZ79819.1 - 0.028 14.6 3.7 0.052 13.7 3.7 1.4 1 0 0 1 1 1 0 4Fe-4S dicluster domain FAINT PF04385.15 AFZ79820.1 - 0.021 14.9 0.1 0.029 14.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79821.1 - 1.5e-16 60.2 16.6 3.3e-06 27.1 0.0 4.3 5 0 0 5 5 5 3 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79822.1 - 2e-20 72.6 0.4 3.1e-11 43.2 2.2 2.2 2 0 0 2 2 2 2 Domain of unknown function, DUF529 DUF4776 PF16003.5 AFZ79823.1 - 0.045 12.7 0.0 0.075 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) TF_Zn_Ribbon PF08271.12 AFZ79823.1 - 0.17 11.4 1.0 0.36 10.4 1.0 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding BRX_N PF13713.6 AFZ79823.1 - 2.2 8.1 5.3 0.45 10.3 0.9 2.1 2 0 0 2 2 2 0 Transcription factor BRX N-terminal domain eIF-1a PF01176.19 AFZ79825.1 - 3e-23 81.4 0.1 4.4e-23 80.9 0.1 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 PCI PF01399.27 AFZ79826.1 - 5.8e-16 58.9 0.3 9.2e-15 55.1 0.0 2.8 3 1 0 3 3 3 1 PCI domain RPN5_C PF18098.1 AFZ79826.1 - 2.6e-11 43.4 0.3 5.5e-11 42.4 0.3 1.6 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain TPR_MalT PF17874.1 AFZ79826.1 - 0.019 14.4 0.0 0.025 14.0 0.0 1.3 1 0 0 1 1 1 0 MalT-like TPR region DUF1949 PF09186.11 AFZ79826.1 - 0.13 12.1 0.5 4.2 7.3 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1949) FemAB PF02388.16 AFZ79826.1 - 0.14 11.0 3.2 0.28 10.0 3.2 1.5 1 0 0 1 1 1 0 FemAB family Snapin_Pallidin PF14712.6 AFZ79827.1 - 0.068 13.6 0.9 0.068 13.6 0.9 1.7 2 0 0 2 2 2 0 Snapin/Pallidin DUF5111 PF17138.4 AFZ79827.1 - 0.089 12.6 1.9 0.19 11.6 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF5111) AAA_23 PF13476.6 AFZ79827.1 - 0.37 11.2 5.2 3 8.3 5.2 2.2 1 1 0 1 1 1 0 AAA domain Brr6_like_C_C PF10104.9 AFZ79830.1 - 4e-34 117.3 4.7 6.2e-34 116.6 4.7 1.2 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain AAA_12 PF13087.6 AFZ79830.1 - 0.058 13.0 0.2 0.12 12.0 0.0 1.6 2 0 0 2 2 2 0 AAA domain Ammonium_transp PF00909.21 AFZ79830.1 - 0.23 10.1 0.4 3.3 6.3 0.1 2.0 2 0 0 2 2 2 0 Ammonium Transporter Family DNA_gyraseA_C PF03989.13 AFZ79831.1 - 4.6e-05 22.8 0.4 0.00016 21.1 0.1 2.1 2 1 0 2 2 2 1 DNA gyrase C-terminal domain, beta-propeller DUF3221 PF11518.8 AFZ79831.1 - 0.11 12.9 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3221) DNA_topoisoIV PF00521.20 AFZ79833.1 - 1.4e-122 409.7 0.1 2e-122 409.2 0.1 1.2 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A PhoLip_ATPase_N PF16209.5 AFZ79834.1 - 1.9e-08 33.9 1.2 1.9e-08 33.9 1.2 1.7 1 1 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal PhoLip_ATPase_C PF16212.5 AFZ79835.1 - 2.2e-38 132.4 28.2 2.2e-38 132.4 28.2 2.1 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal FAINT PF04385.15 AFZ79835.1 - 8.5e-35 118.7 3.0 8.6e-09 35.3 0.0 6.7 6 0 0 6 6 6 6 Domain of unknown function, DUF529 Hydrolase PF00702.26 AFZ79835.1 - 1.3e-12 48.5 0.0 4e-06 27.3 0.0 3.4 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 AFZ79835.1 - 1.1e-08 35.0 0.0 3e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 AFZ79835.1 - 3e-08 33.4 1.6 3e-08 33.4 1.6 2.9 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 AFZ79835.1 - 0.0026 17.5 0.0 0.0026 17.5 0.0 3.1 4 0 0 4 4 4 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 AFZ79835.1 - 0.089 13.2 0.0 24 5.3 0.0 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase PhoLip_ATPase_N PF16209.5 AFZ79835.1 - 0.21 11.3 0.9 0.66 9.7 0.9 1.9 1 0 0 1 1 1 0 Phospholipid-translocating ATPase N-terminal EMA PF02488.15 AFZ79836.1 - 1.1e-33 116.9 10.5 1.3e-33 116.7 10.5 1.0 1 0 0 1 1 1 1 Merozoite Antigen RPN7 PF10602.9 AFZ79836.1 - 0.028 14.1 0.1 0.046 13.4 0.1 1.3 1 0 0 1 1 1 0 26S proteasome subunit RPN7 FAINT PF04385.15 AFZ79836.1 - 0.062 13.4 2.0 1.5 8.9 0.2 3.1 2 1 0 2 2 2 0 Domain of unknown function, DUF529 NusG_II PF07009.11 AFZ79836.1 - 0.082 13.1 3.2 1.4 9.2 0.4 3.1 2 1 1 3 3 3 0 NusG domain II Cor1 PF04803.12 AFZ79837.1 - 0.029 14.6 0.2 0.029 14.6 0.2 3.7 3 1 0 3 3 3 0 Cor1/Xlr/Xmr conserved region WXG100 PF06013.12 AFZ79837.1 - 0.082 13.1 1.3 1.3 9.3 0.0 3.5 3 2 1 4 4 4 0 Proteins of 100 residues with WXG Prominin PF05478.11 AFZ79837.1 - 3.7 5.4 16.4 8.5 4.2 14.5 2.0 1 1 1 2 2 2 0 Prominin DUF842 PF05811.13 AFZ79837.1 - 9.4 5.9 9.6 1.9 8.2 1.5 3.2 2 1 1 3 3 3 0 Eukaryotic protein of unknown function (DUF842) RicinB_lectin_2 PF14200.6 AFZ79839.1 - 0.011 16.5 0.0 0.034 14.9 0.0 1.8 1 0 0 1 1 1 0 Ricin-type beta-trefoil lectin domain-like Ribosomal_L12 PF00542.19 AFZ79844.1 - 2.7e-23 82.1 1.0 3.1e-23 81.9 1.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7/L12 C-terminal domain Pex14_N PF04695.13 AFZ79845.1 - 0.11 13.1 5.5 0.22 12.2 5.5 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Pes-10 PF07149.11 AFZ79845.1 - 2.8 6.9 4.1 4.6 6.2 4.1 1.2 1 0 0 1 1 1 0 Pes-10 Ribosomal_L12_N PF16320.5 AFZ79846.1 - 0.0024 17.6 0.5 0.0024 17.6 0.5 1.9 2 0 0 2 2 2 1 Ribosomal protein L7/L12 dimerisation domain Ribosomal_L12 PF00542.19 AFZ79846.1 - 0.0041 17.4 0.0 0.0083 16.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L7/L12 C-terminal domain AAA_16 PF13191.6 AFZ79847.1 - 5e-05 23.8 0.0 0.00028 21.3 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain ORC5_C PF14630.6 AFZ79847.1 - 0.0038 16.8 0.3 0.0086 15.6 0.3 1.6 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus CFTR_R PF14396.6 AFZ79847.1 - 0.11 12.1 0.2 0.26 10.8 0.2 1.6 1 0 0 1 1 1 0 Cystic fibrosis TM conductance regulator (CFTR), regulator domain FAM198 PF15051.6 AFZ79848.1 - 0.023 13.6 0.0 0.049 12.5 0.0 1.4 1 0 0 1 1 1 0 FAM198 protein DHHC PF01529.20 AFZ79849.1 - 3.8e-34 117.7 10.3 3.8e-34 117.7 10.3 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF2990 PF11693.8 AFZ79852.1 - 0.05 13.8 0.1 0.44 10.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2990) FAINT PF04385.15 AFZ79853.1 - 0.013 15.5 0.0 0.022 14.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function, DUF529 PHM7_ext PF12621.8 AFZ79853.1 - 0.04 14.1 0.0 0.07 13.3 0.0 1.4 1 0 0 1 1 1 0 Extracellular tail, of 10TM putative phosphate transporter FAINT PF04385.15 AFZ79854.1 - 1.1e-25 89.5 6.3 2.9e-05 24.1 0.1 4.4 4 0 0 4 4 4 4 Domain of unknown function, DUF529 OTT_1508_deam PF14441.6 AFZ79854.1 - 0.35 10.9 2.9 12 6.0 0.1 2.7 2 0 0 2 2 2 0 OTT_1508-like deaminase Ribosomal_S5 PF00333.20 AFZ79856.1 - 9.5e-28 96.0 0.8 2e-27 94.9 0.8 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 AFZ79856.1 - 2.9e-21 74.7 0.1 6.4e-21 73.6 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain CRAL_TRIO PF00650.20 AFZ79858.1 - 2.1e-26 92.5 0.8 1.4e-21 76.8 0.0 3.2 3 0 0 3 3 3 2 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 AFZ79858.1 - 0.00055 20.1 0.1 0.0012 19.0 0.1 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain FAINT PF04385.15 AFZ79859.1 - 2.1e-25 88.6 9.1 1.6e-06 28.0 0.1 7.0 6 1 1 7 7 7 6 Domain of unknown function, DUF529 Rhodanese PF00581.20 AFZ79859.1 - 0.00016 22.2 0.1 0.00038 21.0 0.1 1.7 1 0 0 1 1 1 1 Rhodanese-like domain NAR PF16251.5 AFZ79859.1 - 0.056 14.1 0.3 24 5.7 0.0 4.0 4 0 0 4 4 4 0 Nucleic acid-binding domain (NAR) TypeIII_RM_meth PF12564.8 AFZ79859.1 - 0.33 11.1 6.3 7.6 6.7 0.1 3.9 4 0 0 4 4 4 0 Type III restriction/modification enzyme methylation subunit Isy1 PF06246.12 AFZ79863.1 - 9.3e-67 225.3 4.9 1e-66 225.1 4.9 1.0 1 0 0 1 1 1 1 Isy1-like splicing family Cyto_heme_lyase PF01265.17 AFZ79864.1 - 3e-26 92.7 4.1 3.5e-25 89.2 4.1 1.9 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase ASF1_hist_chap PF04729.13 AFZ79865.1 - 3.3e-27 95.3 0.0 7.5e-27 94.2 0.0 1.6 1 0 0 1 1 1 1 ASF1 like histone chaperone Lipoprotein_17 PF04200.12 AFZ79866.1 - 0.053 13.9 0.2 0.18 12.1 0.2 2.0 1 0 0 1 1 1 0 Lipoprotein associated domain ASF1_hist_chap PF04729.13 AFZ79867.1 - 2.3e-17 63.4 0.0 2.3e-17 63.3 0.0 1.1 1 0 0 1 1 1 1 ASF1 like histone chaperone PI3_PI4_kinase PF00454.27 AFZ79868.1 - 6.7e-31 108.0 0.1 1.8e-30 106.6 0.1 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 AFZ79868.1 - 2.3e-09 36.9 0.2 6.7e-09 35.4 0.2 1.9 1 0 0 1 1 1 1 FATC domain FAINT PF04385.15 AFZ79869.1 - 8.7e-08 32.1 25.2 0.00071 19.6 1.1 6.5 6 2 0 6 6 6 4 Domain of unknown function, DUF529 DUF2510 PF10708.9 AFZ79869.1 - 0.02 14.6 0.1 5.9 6.7 0.0 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2510) FAINT PF04385.15 AFZ79870.1 - 1.7e-13 50.4 1.1 7.2e-06 26.0 0.0 2.7 2 1 0 2 2 2 2 Domain of unknown function, DUF529 FHA PF00498.26 AFZ79870.1 - 6e-10 39.3 0.0 1.3e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 AFZ79870.1 - 0.037 14.3 0.0 0.087 13.2 0.0 1.6 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain Collagen PF01391.18 AFZ79871.1 - 1.1e-07 31.5 20.1 3.1e-07 30.1 20.1 1.7 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) FHA PF00498.26 AFZ79872.1 - 0.0031 17.8 0.1 0.0067 16.8 0.1 1.5 1 0 0 1 1 1 1 FHA domain DUF5383 PF17355.2 AFZ79872.1 - 0.66 10.4 3.4 21 5.5 3.7 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5383) RSRP PF17069.5 AFZ79872.1 - 1.5 8.3 23.7 2 7.9 23.7 1.2 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 FAINT PF04385.15 AFZ79873.1 - 0.0015 18.5 0.1 0.0015 18.5 0.1 3.4 4 0 0 4 4 4 2 Domain of unknown function, DUF529 Shikimate_DH PF01488.20 AFZ79873.1 - 0.061 13.4 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase EMA PF02488.15 AFZ79873.1 - 0.15 11.7 5.1 1.4 8.5 0.0 3.4 2 2 1 3 3 3 0 Merozoite Antigen zf-B_box PF00643.24 AFZ79874.1 - 2.6e-05 24.3 11.6 4.2e-05 23.6 11.6 1.3 1 0 0 1 1 1 1 B-box zinc finger Nmad5 PF18757.1 AFZ79874.1 - 0.034 14.4 0.4 0.049 13.8 0.4 1.2 1 0 0 1 1 1 0 Nucleotide modification associated domain 5 Remorin_C PF03763.13 AFZ79874.1 - 0.22 11.4 3.8 0.37 10.7 3.8 1.3 1 0 0 1 1 1 0 Remorin, C-terminal region ACP_PD PF04336.12 AFZ79874.1 - 0.31 11.5 3.0 1.6 9.2 0.6 2.3 1 1 0 2 2 2 0 Acyl carrier protein phosphodiesterase GIT1_C PF12205.8 AFZ79875.1 - 0.13 12.4 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 G protein-coupled receptor kinase-interacting protein 1 C term DUF2507 PF10702.9 AFZ79877.1 - 0.14 12.1 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2507) GlcNAc PF11397.8 AFZ79880.1 - 0.085 12.3 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase (GlcNAc) PRIMA1 PF16101.5 AFZ79880.1 - 3 7.9 14.6 0.3 11.1 7.0 2.5 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 FAINT PF04385.15 AFZ79881.1 - 3.5e-13 49.4 26.3 4.9e-05 23.3 1.0 6.7 7 0 0 7 7 7 4 Domain of unknown function, DUF529 PRCC PF10253.9 AFZ79881.1 - 0.81 10.4 7.6 0.062 14.1 1.9 2.0 2 0 0 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting FAINT PF04385.15 AFZ79883.1 - 2.1e-09 37.3 0.1 1e-05 25.5 0.1 2.8 2 0 0 2 2 2 2 Domain of unknown function, DUF529 UCR_UQCRX_QCR9 PF05365.12 AFZ79883.1 - 0.0072 16.3 1.8 0.008 16.1 0.1 2.0 2 0 0 2 2 2 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like ETRAMP PF09716.10 AFZ79883.1 - 0.12 12.4 0.0 0.38 10.8 0.0 1.8 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Hydrolase_4 PF12146.8 AFZ79885.1 - 9.4e-19 67.6 0.0 8.6e-18 64.5 0.0 2.4 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 AFZ79885.1 - 1.5e-06 29.0 0.0 3.7e-06 27.7 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 AFZ79885.1 - 5.4e-05 23.0 0.4 0.001 18.8 0.2 2.9 2 1 0 2 2 2 1 alpha/beta hydrolase fold FAINT PF04385.15 AFZ79885.1 - 7.3e-05 22.7 10.8 0.0093 16.0 2.6 4.4 3 0 0 3 3 3 1 Domain of unknown function, DUF529 Peptidase_S9 PF00326.21 AFZ79885.1 - 0.0021 17.5 0.0 1.2 8.6 0.0 3.0 3 0 0 3 3 3 2 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 AFZ79885.1 - 0.026 14.4 0.0 0.091 12.6 0.0 1.9 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 AFZ79885.1 - 0.034 14.2 0.0 0.082 13.0 0.0 1.6 1 0 0 1 1 1 0 TAP-like protein DUF829 PF05705.14 AFZ79885.1 - 0.096 12.6 0.2 1.4 8.7 0.1 2.2 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF829) LIDHydrolase PF10230.9 AFZ79885.1 - 0.13 11.8 0.4 0.32 10.5 0.0 1.8 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase Lipoprotein_15 PF03640.15 AFZ79886.1 - 0.57 9.8 2.6 1.7 8.3 0.2 3.0 3 0 0 3 3 3 0 Secreted repeat of unknown function FAINT PF04385.15 AFZ79887.1 - 7.9e-19 67.5 18.3 1.6e-06 28.1 1.2 4.5 4 1 0 4 4 4 4 Domain of unknown function, DUF529 DUF1149 PF06619.11 AFZ79888.1 - 0.05 13.9 0.3 0.085 13.2 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1149) zf-CCCH_4 PF18044.1 AFZ79891.1 - 3.6e-05 23.4 1.7 3.6e-05 23.4 1.7 3.4 4 0 0 4 4 4 2 CCCH-type zinc finger zf-CCCH PF00642.24 AFZ79891.1 - 4.8e-05 23.1 24.7 0.0014 18.5 1.6 4.7 6 0 0 6 6 6 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 AFZ79891.1 - 0.00057 19.9 20.5 0.016 15.2 0.5 4.0 4 0 0 4 4 4 2 Zinc finger domain Torus PF16131.5 AFZ79891.1 - 0.024 15.4 5.4 0.33 11.7 0.0 2.7 2 1 0 2 2 2 0 Torus domain zf-CCCH_2 PF14608.6 AFZ79891.1 - 3.2 8.4 25.2 0.12 12.8 8.0 3.5 4 0 0 4 4 4 0 RNA-binding, Nab2-type zinc finger Chorein_N PF12624.7 AFZ79892.1 - 1.4e-10 41.3 0.2 1e-09 38.5 0.1 2.6 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 VPS13_C PF16909.5 AFZ79892.1 - 8.9e-05 22.3 0.1 0.00026 20.8 0.1 1.9 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal SHR-BD PF06650.12 AFZ79892.1 - 0.39 10.1 7.4 0.25 10.7 0.2 3.3 2 1 1 3 3 3 0 SHR-binding domain of vacuolar-sorting associated protein 13 FAINT PF04385.15 AFZ79893.1 - 7.4e-14 51.6 0.5 8.3e-07 29.0 1.3 2.5 2 1 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79895.1 - 9.3e-13 48.1 1.0 5.7e-07 29.5 0.4 2.3 2 0 0 2 2 2 2 Domain of unknown function, DUF529 EMA PF02488.15 AFZ79895.1 - 0.026 14.2 2.2 1.8 8.2 0.0 2.1 1 1 1 2 2 2 0 Merozoite Antigen FAINT PF04385.15 AFZ79896.1 - 6.3e-17 61.4 1.4 4e-08 33.2 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function, DUF529 T3SS_TC PF06511.11 AFZ79898.1 - 0.11 11.9 0.2 0.26 10.7 0.0 1.6 2 0 0 2 2 2 0 Type III secretion systems tip complex components S4 PF01479.25 AFZ79900.1 - 0.046 13.4 0.1 0.09 12.5 0.1 1.4 1 0 0 1 1 1 0 S4 domain COX2_TM PF02790.15 AFZ79902.1 - 0.03 14.5 0.0 0.039 14.1 0.0 1.2 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane domain ATP_bind_3 PF01171.20 AFZ79903.1 - 4.2e-17 62.5 0.0 7.4e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 PP-loop family PAPS_reduct PF01507.19 AFZ79903.1 - 0.0012 19.0 0.0 0.0027 17.8 0.0 1.8 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family zn-ribbon_14 PF16503.5 AFZ79903.1 - 0.0029 17.1 0.3 0.0029 17.1 0.3 3.3 4 0 0 4 4 4 1 Zinc-ribbon Ras PF00071.22 AFZ79904.1 - 1.5e-58 197.0 0.3 1.9e-58 196.6 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AFZ79904.1 - 4.2e-37 127.0 0.2 5.9e-37 126.6 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AFZ79904.1 - 4e-18 65.5 0.1 9.2e-18 64.3 0.1 1.5 1 1 1 2 2 2 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AFZ79904.1 - 6.9e-10 38.7 0.1 8.5e-10 38.4 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 AFZ79904.1 - 1.2e-06 28.2 0.2 9.7e-06 25.3 0.1 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 AFZ79904.1 - 4.1e-06 26.4 0.0 6e-06 25.8 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 AFZ79904.1 - 2.2e-05 24.5 0.2 0.00014 21.9 0.1 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 AFZ79904.1 - 0.0033 17.5 0.0 0.28 11.2 0.0 2.6 3 0 0 3 3 3 1 Dynamin family RsgA_GTPase PF03193.16 AFZ79904.1 - 0.0039 17.1 0.1 0.057 13.3 0.1 2.1 2 0 0 2 2 2 1 RsgA GTPase PduV-EutP PF10662.9 AFZ79904.1 - 0.03 14.0 0.1 0.088 12.5 0.1 1.8 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation TniB PF05621.11 AFZ79904.1 - 0.046 13.1 0.0 0.13 11.7 0.0 1.8 1 1 1 2 2 2 0 Bacterial TniB protein AAA_16 PF13191.6 AFZ79904.1 - 0.12 12.7 0.0 0.2 12.1 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain TIR_2 PF13676.6 AFZ79904.1 - 0.16 12.5 0.1 1.8 9.2 0.0 2.1 1 1 1 2 2 2 0 TIR domain G-alpha PF00503.20 AFZ79904.1 - 0.17 11.0 1.1 5.4 6.1 0.1 2.8 1 1 1 2 2 2 0 G-protein alpha subunit TIC20 PF16166.5 AFZ79906.1 - 4.7e-09 36.3 5.7 6.8e-09 35.8 5.7 1.2 1 0 0 1 1 1 1 Chloroplast import apparatus Tic20-like FAINT PF04385.15 AFZ79907.1 - 0.00048 20.1 1.0 0.00099 19.1 1.0 1.5 1 0 0 1 1 1 1 Domain of unknown function, DUF529 Ribosomal_L18 PF17135.4 AFZ79908.1 - 1.4e-77 259.3 4.3 1.6e-77 259.2 4.3 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 AFZ79908.1 - 0.00084 20.0 0.1 0.0015 19.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A OprF PF05736.11 AFZ79908.1 - 0.031 14.0 0.0 0.048 13.4 0.0 1.2 1 0 0 1 1 1 0 OprF membrane domain DUF641 PF04859.12 AFZ79909.1 - 0.00059 20.2 2.6 0.098 13.0 0.9 2.3 2 0 0 2 2 2 2 Plant protein of unknown function (DUF641) P4Ha_N PF08336.11 AFZ79909.1 - 0.004 17.2 1.2 0.012 15.6 1.2 1.7 1 0 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region HOOK PF05622.12 AFZ79909.1 - 0.0047 15.1 6.9 0.0063 14.7 6.3 1.5 1 1 0 1 1 1 1 HOOK protein TRF PF08558.10 AFZ79909.1 - 0.0053 16.4 1.8 0.0082 15.8 1.8 1.3 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) FUSC PF04632.12 AFZ79909.1 - 0.12 10.9 0.4 0.16 10.5 0.4 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4111 PF13427.6 AFZ79909.1 - 0.12 12.6 0.2 0.25 11.5 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4111) CAP_N PF01213.19 AFZ79909.1 - 0.28 10.6 3.2 2.2 7.7 2.1 2.0 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Ribosomal_L18A PF01775.17 AFZ79910.1 - 7.8e-52 174.5 0.2 1e-51 174.1 0.2 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A TAFA PF12020.8 AFZ79910.1 - 0.026 14.9 0.1 0.048 14.1 0.1 1.4 1 0 0 1 1 1 0 TAFA family FAINT PF04385.15 AFZ79911.1 - 0.00016 21.7 0.6 0.00016 21.7 0.6 1.9 2 1 0 2 2 2 1 Domain of unknown function, DUF529 Type2_restr_D3 PF16902.5 AFZ79911.1 - 0.31 11.0 2.0 5.9 6.9 0.5 2.5 2 0 0 2 2 2 0 Type-2 restriction enzyme D3 domain ATP-synt_C PF00137.21 AFZ79914.1 - 1.2e-08 35.1 9.1 2.8e-08 34.0 9.1 1.6 1 0 0 1 1 1 1 ATP synthase subunit C FAINT PF04385.15 AFZ79916.1 - 3.5e-12 46.2 0.5 0.006 16.6 0.0 3.5 3 0 0 3 3 3 3 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79917.1 - 8.8e-21 73.8 7.8 6.2e-07 29.4 0.0 4.6 4 0 0 4 4 4 4 Domain of unknown function, DUF529 Hydrolase_4 PF12146.8 AFZ79919.1 - 1.1e-21 77.2 0.0 1.2e-19 70.6 0.0 2.8 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 AFZ79919.1 - 3.9e-06 26.7 0.5 7.9e-06 25.7 0.5 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AFZ79919.1 - 0.00032 21.4 0.0 0.0005 20.7 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 AFZ79919.1 - 0.02 14.7 0.0 0.039 13.8 0.0 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold DUF900 PF05990.12 AFZ79919.1 - 0.13 11.7 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) FAINT PF04385.15 AFZ79920.1 - 2.4e-10 40.3 3.1 2.4e-05 24.3 0.1 2.6 2 1 0 2 2 2 2 Domain of unknown function, DUF529 TubC_N PF18563.1 AFZ79921.1 - 0.082 12.9 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 TubC N-terminal docking domain MerC PF03203.14 AFZ79922.1 - 2.9e-18 66.4 5.8 3.4e-18 66.2 5.8 1.1 1 0 0 1 1 1 1 MerC mercury resistance protein DUF2101 PF09874.9 AFZ79922.1 - 0.028 14.1 0.7 0.036 13.8 0.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2101) YopE PF03545.13 AFZ79922.1 - 0.19 11.9 0.0 0.43 10.8 0.0 1.6 1 0 0 1 1 1 0 Yersinia virulence determinant (YopE) RRM_1 PF00076.22 AFZ79923.1 - 5.9e-34 115.7 0.0 4.3e-16 58.5 0.0 2.7 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 AFZ79923.1 - 5.3e-07 29.5 0.0 0.0016 18.4 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 AFZ79923.1 - 4.2e-06 26.5 0.0 1.6e-05 24.6 0.0 1.9 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_7 PF16367.5 AFZ79923.1 - 0.11 12.6 0.0 2.6 8.3 0.0 2.9 2 1 0 2 2 2 0 RNA recognition motif PKD_3 PF16820.5 AFZ79924.1 - 0.055 13.2 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 PKD-like domain Ribosomal_L2 PF00181.23 AFZ79924.1 - 0.081 12.9 0.3 0.15 12.1 0.3 1.4 1 0 0 1 1 1 0 Ribosomal Proteins L2, RNA binding domain KDGP_aldolase PF07071.11 AFZ79924.1 - 0.14 12.0 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 KDGP aldolase FAINT PF04385.15 AFZ79925.1 - 2.5e-10 40.3 1.4 0.00082 19.4 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function, DUF529 PHtD_u1 PF16645.5 AFZ79925.1 - 0.3 11.5 0.1 0.3 11.5 0.1 1.9 2 0 0 2 2 2 0 Unstructured region on Pneumococcal histidine triad protein FAINT PF04385.15 AFZ79926.1 - 0.0017 18.4 0.8 0.0017 18.4 0.8 3.1 3 1 1 4 4 4 1 Domain of unknown function, DUF529 GPR15L PF15854.5 AFZ79926.1 - 0.35 11.1 1.5 0.47 10.7 0.0 2.0 2 1 0 2 2 2 0 G-protein coupled receptor ligand 15 FAINT PF04385.15 AFZ79927.1 - 7.2e-16 58.0 4.8 2.9e-05 24.0 0.1 5.4 4 2 1 5 5 5 4 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79928.1 - 2.4e-42 142.9 13.4 4.6e-06 26.6 0.1 8.9 8 1 0 8 8 8 8 Domain of unknown function, DUF529 A_deaminase PF00962.22 AFZ79929.1 - 1.8e-73 247.7 0.0 2e-73 247.6 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase Amidohydro_1 PF01979.20 AFZ79929.1 - 0.0038 16.6 0.2 0.013 14.8 0.0 2.0 2 1 0 2 2 2 1 Amidohydrolase family DUF378 PF04070.12 AFZ79929.1 - 0.025 14.4 0.0 0.052 13.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF378) Bmp PF02608.14 AFZ79929.1 - 0.078 11.9 0.0 0.38 9.7 0.0 2.0 2 0 0 2 2 2 0 ABC transporter substrate-binding protein PnrA-like DUF5470 PF17564.2 AFZ79929.1 - 0.23 11.7 2.9 0.82 9.9 0.0 3.2 5 0 0 5 5 5 0 Family of unknown function (DUF5470) FAINT PF04385.15 AFZ79931.1 - 0.022 14.8 0.0 0.032 14.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function, DUF529 ParG PF09274.10 AFZ79932.1 - 0.053 13.7 0.1 3.5 7.8 0.0 2.3 2 0 0 2 2 2 0 ParG DUF5367 PF17329.2 AFZ79933.1 - 0.13 12.4 14.6 0.22 11.7 1.1 3.5 3 0 0 3 3 3 0 Family of unknown function (DUF5367) DUF2663 PF10864.8 AFZ79933.1 - 2.8 8.3 13.1 23 5.4 1.9 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF2663) TTL PF03133.15 AFZ79935.1 - 8.3e-48 163.0 0.3 1.2e-47 162.5 0.3 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 AFZ79935.1 - 9.5e-11 41.4 0.1 7e-07 28.7 0.0 3.3 2 1 1 3 3 3 3 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 AFZ79935.1 - 8.8e-05 21.9 0.0 0.11 11.7 0.0 2.3 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp RimK PF08443.11 AFZ79935.1 - 0.00065 19.4 0.0 0.42 10.2 0.0 2.3 2 0 0 2 2 2 2 RimK-like ATP-grasp domain Prenyltrans PF00432.21 AFZ79936.1 - 7.9e-41 137.5 1.7 2.3e-10 40.0 0.1 5.7 5 0 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat DUF4041 PF13250.6 AFZ79936.1 - 0.012 15.5 0.0 0.03 14.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4041) SQHop_cyclase_N PF13249.6 AFZ79936.1 - 0.023 13.8 0.0 2 7.4 0.0 2.7 1 1 2 3 3 3 0 Squalene-hopene cyclase N-terminal domain SSXT PF05030.12 AFZ79937.1 - 6.4e-06 25.7 1.3 1.4e-05 24.6 0.2 2.1 2 1 0 2 2 2 1 SSXT protein (N-terminal region) EF-hand_1 PF00036.32 AFZ79938.1 - 3.1e-06 26.3 0.6 0.081 12.5 0.1 3.0 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 AFZ79938.1 - 3.6e-05 24.1 0.7 0.21 12.0 0.3 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 AFZ79938.1 - 6.1e-05 22.8 0.8 0.28 11.1 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 AFZ79938.1 - 0.0014 18.0 1.7 1.1 8.9 0.1 3.2 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 AFZ79938.1 - 0.0023 17.7 0.4 2.1 8.5 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain PITH PF06201.13 AFZ79940.1 - 5.9e-28 98.0 0.0 7.1e-28 97.7 0.0 1.1 1 0 0 1 1 1 1 PITH domain Peptidase_S24 PF00717.23 AFZ79942.1 - 0.051 13.5 0.1 0.3 11.1 0.1 2.2 2 1 0 2 2 2 0 Peptidase S24-like Reprolysin_3 PF13582.6 AFZ79945.1 - 0.0089 16.5 0.1 0.37 11.3 0.1 2.4 2 0 0 2 2 2 2 Metallo-peptidase family M12B Reprolysin-like RRM_1 PF00076.22 AFZ79946.1 - 2.4e-38 129.8 0.0 3e-19 68.6 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 AFZ79946.1 - 0.0084 15.7 0.0 0.45 10.1 0.0 2.1 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AFZ79946.1 - 0.024 14.5 0.0 0.05 13.5 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif GDP_Man_Dehyd PF16363.5 AFZ79946.1 - 0.089 12.2 0.3 0.12 11.8 0.3 1.4 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase Limkain-b1 PF11608.8 AFZ79946.1 - 0.094 12.8 0.2 2.8 8.1 0.0 2.4 2 1 0 2 2 2 0 Limkain b1 Auto_anti-p27 PF06677.12 AFZ79947.1 - 7.3e-14 51.6 6.7 1.4e-13 50.8 6.7 1.5 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Thioredoxin PF00085.20 AFZ79948.1 - 1.4e-10 41.1 0.0 2.4e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.16 AFZ79948.1 - 2.3e-09 36.6 0.1 2.7e-09 36.4 0.1 1.1 1 0 0 1 1 1 1 Phosducin tRNA_m1G_MT PF01746.21 AFZ79949.1 - 1.4e-19 70.6 0.0 2e-19 70.1 0.0 1.2 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase Peptidase_M24 PF00557.24 AFZ79950.1 - 1.2e-48 165.6 0.0 1.5e-48 165.3 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 AFZ79950.1 - 3.9e-11 43.1 8.3 6.8e-11 42.3 8.3 1.4 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 AFZ79950.1 - 0.0037 17.3 6.2 0.017 15.2 6.2 2.1 1 1 0 1 1 1 1 MYND finger RecR PF02132.15 AFZ79950.1 - 0.06 12.9 1.6 0.21 11.2 1.6 2.0 1 0 0 1 1 1 0 RecR protein DUF1851 PF08906.11 AFZ79950.1 - 0.15 12.0 0.0 0.37 10.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1851) RMI1_N PF08585.12 AFZ79951.1 - 9.7e-08 32.0 0.0 3.4e-07 30.3 0.0 1.8 1 1 0 1 1 1 1 RecQ mediated genome instability protein NTP_transf_2 PF01909.23 AFZ79952.1 - 3.3e-07 30.5 0.0 8.4e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 AFZ79952.1 - 0.01 15.9 0.0 0.024 14.7 0.0 1.7 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase Nrap_D2 PF17403.2 AFZ79952.1 - 0.038 13.8 0.0 0.071 12.9 0.0 1.5 1 0 0 1 1 1 0 Nrap protein PAP/OAS-like domain FBA_2 PF07735.17 AFZ79952.1 - 0.19 11.8 0.1 0.19 11.8 0.1 3.2 3 1 1 4 4 4 0 F-box associated Cpn60_TCP1 PF00118.24 AFZ79953.1 - 4.1e-96 322.5 12.7 5.4e-96 322.2 12.7 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ribosomal_S5 PF00333.20 AFZ79955.1 - 3.7e-13 49.3 0.1 6.2e-13 48.5 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 AFZ79955.1 - 6.4e-08 31.9 0.0 1.4e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain partial_CstF PF15861.5 AFZ79955.1 - 0.15 11.9 1.2 2.2 8.1 0.0 2.9 2 0 0 2 2 2 0 Partial cleavage stimulation factor domain TryThrA_C PF12319.8 AFZ79955.1 - 0.62 9.5 5.8 0.14 11.6 1.7 1.9 2 0 0 2 2 2 0 Tryptophan-Threonine-rich plasmodium antigen C terminal FAINT PF04385.15 AFZ79956.1 - 2.7e-08 33.8 2.0 6.9e-08 32.4 0.2 2.4 2 0 0 2 2 2 1 Domain of unknown function, DUF529 tRNA-synt_2b PF00587.25 AFZ79960.1 - 0.16 11.9 0.0 0.18 11.8 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) Histone PF00125.24 AFZ79962.1 - 3.6e-19 69.4 0.9 4.3e-19 69.2 0.9 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID_20kDa PF03847.13 AFZ79962.1 - 0.0033 17.9 0.7 0.0043 17.5 0.0 1.5 2 0 0 2 2 2 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.23 AFZ79962.1 - 0.0054 17.0 0.5 0.011 16.0 0.0 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PHD PF00628.29 AFZ79963.1 - 3.8e-12 45.9 6.6 3.8e-12 45.9 6.6 2.5 2 0 0 2 2 2 1 PHD-finger zf-RING_2 PF13639.6 AFZ79963.1 - 1.5e-10 41.2 22.2 8.3e-09 35.6 8.0 2.4 2 0 0 2 2 2 2 Ring finger domain zf-rbx1 PF12678.7 AFZ79963.1 - 4.4e-08 33.3 14.6 4.5e-07 30.1 4.5 2.7 2 0 0 2 2 2 2 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 AFZ79963.1 - 1.6e-07 31.1 19.8 6.1e-07 29.2 7.4 2.5 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AFZ79963.1 - 7.2e-06 25.8 4.6 7.2e-06 25.8 4.6 2.2 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AFZ79963.1 - 1e-05 25.3 18.8 1.2e-05 25.1 6.1 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AFZ79963.1 - 4.4e-05 23.3 5.4 4.4e-05 23.3 5.4 2.5 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 AFZ79963.1 - 8.9e-05 22.3 6.2 8.9e-05 22.3 6.2 2.1 2 1 1 3 3 2 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 AFZ79963.1 - 0.00069 19.6 4.5 0.00069 19.6 4.5 2.8 2 0 0 2 2 2 1 RING-type zinc-finger PHD_2 PF13831.6 AFZ79963.1 - 0.0068 15.9 2.1 0.017 14.7 2.1 1.7 1 0 0 1 1 1 1 PHD-finger zf-RING_11 PF17123.5 AFZ79963.1 - 0.01 15.6 18.6 0.024 14.4 8.0 2.5 2 0 0 2 2 2 0 RING-like zinc finger zf-C3HC4_4 PF15227.6 AFZ79963.1 - 0.028 14.6 2.8 0.028 14.6 2.8 2.8 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 AFZ79963.1 - 0.04 13.5 14.8 0.27 10.9 4.3 2.5 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Zn_ribbon_SprT PF17283.2 AFZ79963.1 - 0.048 13.6 0.2 9.6 6.2 0.0 2.9 2 0 0 2 2 2 0 SprT-like zinc ribbon domain zf-ANAPC11 PF12861.7 AFZ79963.1 - 0.06 13.4 10.0 0.34 11.0 1.7 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 AFZ79963.1 - 0.99 9.3 7.9 0.34 10.8 4.5 2.0 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 AFZ79963.1 - 3.9 7.7 7.2 0.52 10.5 1.4 2.4 2 0 0 2 2 2 0 zinc RING finger of MSL2 FANCI_S1-cap PF14674.6 AFZ79964.1 - 0.063 13.4 0.3 0.11 12.6 0.3 1.4 1 0 0 1 1 1 0 FANCI solenoid 1 cap FAINT PF04385.15 AFZ79965.1 - 9.9e-10 38.3 0.7 3.6e-06 26.9 0.9 2.6 2 0 0 2 2 2 2 Domain of unknown function, DUF529 EMA PF02488.15 AFZ79965.1 - 0.00059 19.6 0.6 0.084 12.5 0.2 2.2 2 0 0 2 2 2 2 Merozoite Antigen Mut7-C PF01927.16 AFZ79966.1 - 0.56 10.3 5.0 0.28 11.3 1.9 2.1 2 0 0 2 2 2 0 Mut7-C RNAse domain PHD_4 PF16866.5 AFZ79966.1 - 1.3 9.1 9.0 0.72 10.0 4.7 2.9 2 0 0 2 2 2 0 PHD-finger zf-rbx1 PF12678.7 AFZ79966.1 - 1.9 8.8 4.9 7.7 6.9 4.9 2.1 1 0 0 1 1 1 0 RING-H2 zinc finger domain DUF5344 PF17279.2 AFZ79967.1 - 0.0046 17.5 2.2 0.02 15.4 1.3 2.4 1 1 1 2 2 2 1 Family of unknown function (DUF5344) Fez1 PF06818.15 AFZ79967.1 - 0.033 14.6 0.9 0.062 13.8 0.9 1.5 1 1 0 1 1 1 0 Fez1 LepB_GAP_N PF18172.1 AFZ79967.1 - 0.052 13.4 1.3 4.7 7.1 0.0 2.6 1 1 1 3 3 3 0 LepB GAP domain N-terminal subdomain Nsp1_C PF05064.13 AFZ79967.1 - 0.091 12.6 3.6 10 5.9 0.2 3.3 2 1 1 3 3 3 0 Nsp1-like C-terminal region FapA PF03961.13 AFZ79967.1 - 0.19 10.3 3.4 0.49 8.9 3.0 1.7 1 1 0 1 1 1 0 Flagellar Assembly Protein A DUF1664 PF07889.12 AFZ79967.1 - 0.19 11.7 2.8 3.2 7.8 0.9 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Mt_ATP-synt_D PF05873.12 AFZ79967.1 - 0.48 10.3 5.2 0.45 10.4 0.4 2.2 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) FlaC_arch PF05377.11 AFZ79967.1 - 1 9.8 7.4 2.4 8.6 0.6 3.2 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) Ribosomal_L18_c PF14204.6 AFZ79967.1 - 1.3 10.0 6.5 7.5 7.6 2.0 2.6 1 1 2 3 3 3 0 Ribosomal L18 C-terminal region FAINT PF04385.15 AFZ79968.1 - 1.3e-17 63.6 0.0 7.1e-08 32.4 0.0 2.8 3 0 0 3 3 3 2 Domain of unknown function, DUF529 EMA PF02488.15 AFZ79972.1 - 1e-24 87.6 0.6 1.2e-24 87.3 0.6 1.0 1 0 0 1 1 1 1 Merozoite Antigen FAINT PF04385.15 AFZ79973.1 - 0.0048 16.9 1.5 0.0048 16.9 1.5 3.0 2 1 0 2 2 2 1 Domain of unknown function, DUF529 Sugar_tr PF00083.24 AFZ79974.1 - 1.8e-61 208.4 32.0 2.3e-61 208.1 32.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AFZ79974.1 - 1.9e-12 46.8 33.0 1.2e-08 34.3 10.7 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 AFZ79974.1 - 7.9e-05 21.3 3.4 7.9e-05 21.3 3.4 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) CYYR1 PF10873.8 AFZ79974.1 - 1.8 9.0 7.4 0.22 12.0 2.0 2.3 2 1 0 2 2 2 0 Cysteine and tyrosine-rich protein 1 FAINT PF04385.15 AFZ79976.1 - 2.8e-06 27.3 0.0 0.0062 16.6 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79977.1 - 6.5e-10 38.9 0.0 0.05 13.7 0.0 3.4 3 0 0 3 3 3 3 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ79978.1 - 2.4e-16 59.5 2.3 5.1e-06 26.5 0.0 3.7 3 1 0 3 3 3 3 Domain of unknown function, DUF529 Late_protein_L2 PF00513.18 AFZ79978.1 - 0.3 10.1 8.1 0.49 9.3 8.1 1.3 1 0 0 1 1 1 0 Late Protein L2 RRN3 PF05327.11 AFZ79978.1 - 5.7 5.4 7.1 9 4.7 7.1 1.4 1 1 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 FAINT PF04385.15 AFZ79981.1 - 6.1e-08 32.6 0.4 1.1e-07 31.8 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 UQ_con PF00179.26 AFZ79983.1 - 2.5e-44 150.3 0.0 2.9e-44 150.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 AFZ79983.1 - 0.016 15.0 0.1 0.043 13.7 0.1 1.7 1 1 0 1 1 1 0 UEV domain Prok-E2_B PF14461.6 AFZ79983.1 - 0.034 13.8 0.0 0.045 13.4 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B MCM PF00493.23 AFZ79984.1 - 1.2e-82 276.4 0.0 1.8e-82 275.8 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 AFZ79984.1 - 1.2e-21 76.9 0.1 3.7e-21 75.3 0.1 1.9 1 1 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 AFZ79984.1 - 1.5e-15 57.4 4.7 9.5e-15 54.8 4.7 2.4 1 1 0 1 1 1 1 MCM AAA-lid domain AAA_5 PF07728.14 AFZ79984.1 - 1.6e-08 34.7 0.0 3.4e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 AFZ79984.1 - 3.5e-08 33.1 0.2 0.0034 16.8 0.0 2.3 1 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 AFZ79984.1 - 0.00029 20.7 0.0 0.001 18.9 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 AFZ79984.1 - 0.00059 20.3 0.0 0.0013 19.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 AFZ79984.1 - 0.0067 16.1 0.0 1.5 8.5 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_16 PF13191.6 AFZ79984.1 - 0.021 15.2 1.1 0.11 12.9 0.0 2.7 2 1 1 3 3 3 0 AAA ATPase domain NACHT PF05729.12 AFZ79984.1 - 0.031 14.2 0.3 0.96 9.3 0.0 2.7 2 0 0 2 2 2 0 NACHT domain ABC_tran PF00005.27 AFZ79984.1 - 0.075 13.6 0.1 0.44 11.1 0.0 2.1 2 1 0 2 2 2 0 ABC transporter AAA_7 PF12775.7 AFZ79984.1 - 0.077 12.5 0.0 0.2 11.1 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 AFZ79984.1 - 0.19 12.0 1.1 0.93 9.8 0.0 2.5 2 1 1 3 3 2 0 AAA domain EMP24_GP25L PF01105.24 AFZ79985.1 - 5.9e-30 104.5 2.3 6.7e-30 104.4 2.3 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF5319 PF17252.2 AFZ79985.1 - 0.035 14.3 0.1 0.051 13.8 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5319) TOM13 PF08219.11 AFZ79985.1 - 0.052 13.5 0.1 2.2 8.3 0.0 2.2 2 0 0 2 2 2 0 Outer membrane protein TOM13 Ribosom_S12_S23 PF00164.25 AFZ79987.1 - 3.2e-27 94.4 0.4 5.9e-27 93.5 0.4 1.4 1 0 0 1 1 1 1 Ribosomal protein S12/S23 FAINT PF04385.15 AFZ79988.1 - 1.9e-25 88.7 5.7 0.00033 20.7 0.0 6.6 6 0 0 6 6 6 6 Domain of unknown function, DUF529 DUF3047 PF11249.8 AFZ79989.1 - 0.012 15.1 0.3 1.2 8.6 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3047) DUF5517 PF17639.2 AFZ79992.1 - 0.054 13.8 0.1 4.7 7.6 0.1 3.7 3 0 0 3 3 3 0 Family of unknown function (DUF5517) DUF3991 PF13154.6 AFZ79992.1 - 0.18 12.2 0.7 0.76 10.2 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3991) HSP70 PF00012.20 AFZ79994.1 - 2.6e-15 55.7 0.3 2.6e-15 55.7 0.3 1.6 1 1 0 1 1 1 1 Hsp70 protein TPR_1 PF00515.28 AFZ79994.1 - 3.3e-05 23.5 4.6 0.0053 16.5 0.1 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 AFZ79994.1 - 7.3e-05 22.4 0.7 0.2 11.4 0.0 3.0 3 0 0 3 3 3 2 TPR repeat TPR_2 PF07719.17 AFZ79994.1 - 0.00019 21.3 0.6 0.13 12.4 0.1 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat SPO22 PF08631.10 AFZ79994.1 - 0.0014 18.1 0.2 0.0026 17.3 0.2 1.3 1 0 0 1 1 1 1 Meiosis protein SPO22/ZIP4 like TPR_9 PF13371.6 AFZ79994.1 - 0.0058 16.8 0.0 0.015 15.4 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 AFZ79994.1 - 0.0059 16.9 0.1 0.096 13.1 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 AFZ79994.1 - 0.0095 16.5 0.2 2.4 9.0 0.2 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 AFZ79994.1 - 0.37 11.5 0.8 3.7 8.3 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat HSP70 PF00012.20 AFZ79995.1 - 1.1e-08 33.7 0.0 1.2e-08 33.7 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein DUF3770 PF12603.8 AFZ79995.1 - 0.14 11.6 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3770) GATase_2 PF00310.21 AFZ79996.1 - 0.017 13.8 0.0 0.021 13.5 0.0 1.1 1 0 0 1 1 1 0 Glutamine amidotransferases class-II PRA-CH PF01502.18 AFZ79997.1 - 0.0068 16.2 0.1 0.056 13.3 0.0 2.6 2 0 0 2 2 2 1 Phosphoribosyl-AMP cyclohydrolase Flavokinase PF01687.17 AFZ79998.1 - 1.8e-23 83.0 0.0 2.2e-23 82.6 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase CcdA PF07362.12 AFZ79999.1 - 7e-05 23.2 0.1 0.00021 21.6 0.1 1.8 1 0 0 1 1 1 1 Post-segregation antitoxin CcdA BAG PF02179.16 AFZ79999.1 - 0.1 13.0 0.1 0.1 13.0 0.1 2.9 3 2 0 3 3 3 0 BAG domain DUF719 PF05334.13 AFZ79999.1 - 1.6 8.9 8.5 1.1 9.5 1.3 2.7 1 1 1 3 3 3 0 Protein of unknown function (DUF719) PhoU_div PF01865.16 AFZ79999.1 - 2.1 7.6 15.2 0.066 12.5 3.3 2.9 2 1 1 3 3 3 0 Protein of unknown function DUF47 DUF3160 PF11369.8 AFZ79999.1 - 2.3 6.6 10.2 1.2 7.5 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3160) IZUMO PF15005.6 AFZ79999.1 - 6.8 7.2 20.1 17 5.9 2.0 4.1 2 2 2 4 4 4 0 Izumo sperm-egg fusion, Ig domain-associated MitMem_reg PF13012.6 AFZ79999.1 - 9.3 6.7 9.9 7.5 7.0 1.0 2.9 2 2 0 2 2 2 0 Maintenance of mitochondrial structure and function Piezo_RRas_bdg PF12166.8 AFZ80001.1 - 0.0059 15.9 0.1 0.013 14.8 0.0 1.6 2 0 0 2 2 2 1 Piezo non-specific cation channel, R-Ras-binding domain DUF1444 PF07285.11 AFZ80001.1 - 0.081 12.5 0.1 1.7 8.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1444) zf_C2HC_14 PF18574.1 AFZ80003.1 - 0.12 12.2 0.0 0.41 10.5 0.0 2.0 1 0 0 1 1 1 0 C2HC Zing finger domain Aldo_ket_red PF00248.21 AFZ80005.1 - 9.3e-55 185.9 0.0 1.2e-54 185.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Rbx_binding PF18113.1 AFZ80006.1 - 0.043 13.6 0.0 0.082 12.7 0.0 1.4 1 0 0 1 1 1 0 Rubredoxin binding C-terminal domain Ribosomal_L29 PF00831.23 AFZ80009.1 - 0.083 12.9 0.0 1.2 9.1 0.0 2.4 2 0 0 2 2 2 0 Ribosomal L29 protein DUF3836 PF12930.7 AFZ80009.1 - 0.2 11.4 3.3 0.33 10.7 3.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF3836) Ribosomal_S13_N PF08069.12 AFZ80011.1 - 2.9e-27 94.5 0.3 5.3e-27 93.6 0.3 1.4 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 AFZ80011.1 - 5e-14 52.3 0.7 8.4e-14 51.5 0.7 1.4 1 0 0 1 1 1 1 Ribosomal protein S15 Prefoldin_2 PF01920.20 AFZ80013.1 - 0.089 12.8 0.6 0.089 12.8 0.6 2.7 3 1 0 3 3 3 0 Prefoldin subunit FAINT PF04385.15 AFZ80014.1 - 0.0004 20.4 0.5 0.12 12.5 0.0 3.2 3 0 0 3 3 3 2 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ80015.1 - 2.6e-37 126.7 19.1 2.7e-12 46.6 2.2 6.4 6 0 0 6 6 6 5 Domain of unknown function, DUF529 DUF3519 PF12033.8 AFZ80015.1 - 0.053 13.9 0.3 0.053 13.9 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3519) Thx PF17070.5 AFZ80015.1 - 3 8.1 7.5 0.2 11.8 1.0 2.6 2 0 0 2 2 2 0 30S ribosomal protein Thx FAINT PF04385.15 AFZ80016.1 - 3.7e-30 103.8 16.9 4.1e-11 42.8 0.6 6.1 6 0 0 6 6 6 5 Domain of unknown function, DUF529 NOT2_3_5 PF04153.18 AFZ80016.1 - 0.0088 16.1 4.0 6.4 6.9 0.3 4.4 4 0 0 4 4 4 2 NOT2 / NOT3 / NOT5 family FAINT PF04385.15 AFZ80017.1 - 1.4e-08 34.6 2.0 0.00048 20.1 0.1 2.5 2 1 0 2 2 2 2 Domain of unknown function, DUF529 LPD3 PF18798.1 AFZ80017.1 - 0.087 13.1 0.1 0.14 12.5 0.1 1.3 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 3 FAINT PF04385.15 AFZ80018.1 - 1.7e-05 24.8 0.0 0.0049 16.9 0.0 2.4 2 1 0 2 2 2 2 Domain of unknown function, DUF529 DUF4670 PF15709.5 AFZ80019.1 - 0.17 11.2 0.0 0.21 10.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4670) Med9 PF07544.13 AFZ80022.1 - 0.0021 18.1 8.0 0.43 10.7 0.0 3.5 3 0 0 3 3 3 2 RNA polymerase II transcription mediator complex subunit 9 Tektin PF03148.14 AFZ80022.1 - 0.083 11.6 6.5 2.5 6.8 0.6 3.0 2 1 1 3 3 3 0 Tektin family Laminin_II PF06009.12 AFZ80022.1 - 0.15 12.1 6.4 4.2 7.4 0.0 3.3 3 1 0 3 3 3 0 Laminin Domain II Prefoldin_2 PF01920.20 AFZ80022.1 - 0.21 11.6 9.9 0.22 11.5 3.6 3.3 2 1 1 3 3 3 0 Prefoldin subunit Prominin PF05478.11 AFZ80022.1 - 0.25 9.2 2.1 0.41 8.5 0.8 1.9 2 0 0 2 2 2 0 Prominin DUF641 PF04859.12 AFZ80022.1 - 0.29 11.5 5.6 0.31 11.4 0.2 2.6 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DUF948 PF06103.11 AFZ80022.1 - 0.48 10.7 3.0 5.8 7.2 0.5 3.6 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Gp-FAR-1 PF05823.12 AFZ80022.1 - 3.3 8.0 11.1 1.9 8.8 0.1 3.6 3 1 0 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF4298 PF14131.6 AFZ80022.1 - 4.6 7.3 9.5 0.63 10.0 0.4 3.7 4 2 2 6 6 6 0 Domain of unknown function (DUF4298) Mod_r PF07200.13 AFZ80022.1 - 6.5 6.8 9.3 5.8 7.0 0.7 3.1 3 1 1 4 4 4 0 Modifier of rudimentary (Mod(r)) protein FAINT PF04385.15 AFZ80024.1 - 0.0015 18.5 0.1 0.0027 17.8 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 DUF3533 PF12051.8 AFZ80025.1 - 0.062 12.2 0.0 0.074 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) HBB PF06777.11 AFZ80025.1 - 0.067 12.9 0.1 3.4 7.3 0.1 2.2 1 1 1 2 2 2 0 Helical and beta-bridge domain Myosin_head PF00063.21 AFZ80026.1 - 3.5e-186 620.4 0.1 4.3e-186 620.1 0.1 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_16 PF13191.6 AFZ80026.1 - 0.037 14.4 0.0 0.074 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain CbiA PF01656.23 AFZ80026.1 - 0.094 12.8 0.0 0.22 11.6 0.0 1.8 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain T2SSE PF00437.20 AFZ80026.1 - 0.18 10.9 0.0 0.37 9.8 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein FAINT PF04385.15 AFZ80028.1 - 5.9e-11 42.3 9.8 4.8e-09 36.1 0.4 3.2 2 1 1 3 3 3 2 Domain of unknown function, DUF529 Phage_tail_X PF05489.12 AFZ80028.1 - 0.051 13.3 0.1 0.098 12.3 0.1 1.4 1 0 0 1 1 1 0 Phage Tail Protein X DUF751 PF05421.11 AFZ80029.1 - 0.49 11.2 5.3 0.54 11.0 3.4 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF751) Hydrolase_4 PF12146.8 AFZ80031.1 - 2.9e-22 79.1 0.0 2.3e-20 72.9 0.0 2.9 2 1 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 AFZ80031.1 - 3e-15 56.0 4.8 0.00025 21.0 0.0 4.1 3 1 1 4 4 4 3 Domain of unknown function, DUF529 Abhydrolase_1 PF00561.20 AFZ80031.1 - 0.0071 16.0 0.0 0.018 14.7 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 AFZ80031.1 - 0.18 11.7 0.0 0.32 10.8 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Elf1 PF05129.13 AFZ80032.1 - 0.0015 18.5 0.5 2.1 8.4 0.1 4.0 4 0 0 4 4 4 2 Transcription elongation factor Elf1 like FAINT PF04385.15 AFZ80034.1 - 0.0028 17.7 0.0 0.0039 17.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ80036.1 - 1.9e-25 88.7 1.2 1.2e-06 28.4 0.0 4.5 4 0 0 4 4 4 4 Domain of unknown function, DUF529 Exo_endo_phos PF03372.23 AFZ80038.1 - 4.4e-16 59.1 0.0 1.1e-15 57.8 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RRM_1 PF00076.22 AFZ80039.1 - 8.2e-55 182.5 0.3 3.1e-19 68.6 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WW PF00397.26 AFZ80039.1 - 6.6e-11 42.1 5.0 1.3e-10 41.1 5.0 1.5 1 0 0 1 1 1 1 WW domain RRM_5 PF13893.6 AFZ80039.1 - 3.2e-10 39.7 0.1 0.062 12.9 0.2 3.2 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 AFZ80039.1 - 4e-09 36.4 0.0 0.0036 17.3 0.0 3.6 3 0 0 3 3 3 2 RNA binding domain RRM_7 PF16367.5 AFZ80039.1 - 6.5e-09 35.8 0.2 0.032 14.3 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif RRM_occluded PF16842.5 AFZ80039.1 - 0.00024 20.9 0.0 0.43 10.5 0.0 3.2 3 0 0 3 3 3 1 Occluded RNA-recognition motif Nup35_RRM PF05172.13 AFZ80039.1 - 0.0007 19.5 0.0 0.045 13.7 0.0 2.8 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 AFZ80039.1 - 0.0092 16.2 0.7 5.9 7.1 0.1 3.4 3 1 1 4 4 4 1 Cytosolic domain of 10TM putative phosphate transporter Limkain-b1 PF11608.8 AFZ80039.1 - 0.021 14.9 0.1 0.086 12.9 0.0 2.0 2 0 0 2 2 2 0 Limkain b1 DUF1866 PF08952.11 AFZ80039.1 - 0.054 13.3 0.0 0.4 10.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1866) RNB PF00773.19 AFZ80040.1 - 7.5e-94 314.7 0.0 1.2e-93 314.1 0.0 1.3 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 AFZ80040.1 - 3.6e-16 59.0 0.0 1.1e-15 57.4 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 AFZ80040.1 - 1e-05 25.6 0.0 5e-05 23.4 0.1 2.2 2 0 0 2 2 2 1 Cold shock domain Rrp44_CSD1 PF17216.3 AFZ80040.1 - 0.0015 18.3 0.0 0.0037 17.0 0.0 1.7 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 AFZ80040.1 - 0.098 12.6 0.0 0.32 11.0 0.0 1.9 1 0 0 1 1 1 0 S1 domain MoaC PF01967.21 AFZ80040.1 - 0.15 12.1 0.7 5.4 7.1 0.3 2.4 2 0 0 2 2 2 0 MoaC family DUF2052 PF09747.9 AFZ80041.1 - 0.011 15.9 5.0 0.011 15.9 5.0 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Na_trans_assoc PF06512.13 AFZ80041.1 - 0.18 12.0 18.6 1 9.6 2.3 2.3 2 0 0 2 2 2 0 Sodium ion transport-associated SpoIIIAH PF12685.7 AFZ80041.1 - 0.65 9.8 13.3 1.7 8.4 6.3 2.2 2 0 0 2 2 2 0 SpoIIIAH-like protein RNA_pol_3_Rpc31 PF11705.8 AFZ80041.1 - 1.1 9.5 24.4 0.096 12.9 12.5 2.5 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 DUF4050 PF13259.6 AFZ80041.1 - 1.5 9.1 10.6 1.2 9.5 5.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) SAPS PF04499.15 AFZ80041.1 - 1.8 7.2 8.4 0.47 9.2 2.2 2.0 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein DUF4746 PF15928.5 AFZ80041.1 - 2.8 7.3 26.9 0.37 10.2 15.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Nop14 PF04147.12 AFZ80041.1 - 4.5 5.4 23.2 0.036 12.3 10.0 2.0 2 0 0 2 2 2 0 Nop14-like family BUD22 PF09073.10 AFZ80041.1 - 7.1 5.9 23.5 0.97 8.7 12.3 2.1 2 0 0 2 2 2 0 BUD22 DUF3551 PF12071.8 AFZ80042.1 - 0.0053 16.8 0.5 0.0078 16.2 0.3 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3551) PEPCK_ATP PF01293.20 AFZ80043.1 - 2.5e-43 148.4 0.0 3.1e-43 148.2 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase Phytochelatin_C PF09328.10 AFZ80044.1 - 0.14 11.5 0.0 2.3 7.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1984) PEPCK_ATP PF01293.20 AFZ80045.1 - 5.5e-153 510.0 0.0 6.3e-153 509.8 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.6 AFZ80045.1 - 0.0038 17.4 0.0 0.0059 16.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AFZ80045.1 - 0.043 14.2 0.0 0.075 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain APS_kinase PF01583.20 AFZ80045.1 - 0.061 13.2 0.1 0.18 11.7 0.0 1.8 3 0 0 3 3 3 0 Adenylylsulphate kinase AP2 PF00847.20 AFZ80046.1 - 9.6e-17 61.0 1.5 1.2e-06 28.7 0.1 3.5 3 0 0 3 3 3 3 AP2 domain Gag_p30 PF02093.16 AFZ80046.1 - 0.13 11.8 0.6 16 4.9 0.0 2.6 2 0 0 2 2 2 0 Gag P30 core shell protein UDPGP PF01704.18 AFZ80048.1 - 6.9e-16 57.9 0.1 5e-09 35.3 0.0 2.3 2 1 0 2 2 2 2 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 AFZ80048.1 - 9.7e-07 29.3 0.0 1.9e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 MobA-like NTP transferase domain Kelch_1 PF01344.25 AFZ80049.1 - 6.1e-53 176.2 2.8 5.2e-11 41.9 0.0 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 AFZ80049.1 - 5.2e-31 105.9 1.0 1.5e-05 25.1 0.0 6.3 5 1 1 6 6 6 6 Kelch motif Kelch_4 PF13418.6 AFZ80049.1 - 2.2e-21 75.6 2.8 3.4e-05 23.7 0.0 5.9 5 2 1 6 6 6 4 Galactose oxidase, central domain BTB_2 PF02214.22 AFZ80049.1 - 1.3e-17 64.0 0.2 4.2e-17 62.3 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain Kelch_3 PF13415.6 AFZ80049.1 - 2.5e-15 56.3 2.3 0.015 15.6 0.1 6.4 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_2 PF07646.15 AFZ80049.1 - 1.9e-10 40.3 5.9 0.017 15.1 0.0 6.2 5 1 1 6 6 6 3 Kelch motif Kelch_5 PF13854.6 AFZ80049.1 - 8.7e-08 32.0 7.2 0.6 10.2 0.0 6.4 7 0 0 7 7 7 3 Kelch motif DUF501 PF04417.12 AFZ80049.1 - 0.051 13.4 0.6 0.051 13.4 0.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF501) Exonuc_VII_L PF02601.15 AFZ80049.1 - 3.3 7.2 8.3 4.9 6.6 8.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit OST3_OST6 PF04756.13 AFZ80051.1 - 7.5e-10 38.6 0.2 0.0027 17.1 0.0 3.1 3 0 0 3 3 3 3 OST3 / OST6 family, transporter family DUF2208 PF09973.9 AFZ80051.1 - 0.048 13.3 0.2 0.11 12.1 0.2 1.6 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) Chorein_N PF12624.7 AFZ80052.1 - 2.4e-19 69.5 0.5 1.3e-18 67.2 0.5 2.4 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 VPS13_C PF16909.5 AFZ80052.1 - 1.1e-09 38.3 0.0 3.9e-09 36.5 0.0 1.9 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal VPS13 PF16908.5 AFZ80052.1 - 1.3e-08 34.9 0.3 2.1e-06 27.8 0.0 3.5 4 0 0 4 4 4 1 Vacuolar sorting-associated protein 13, N-terminal WD40 PF00400.32 AFZ80053.1 - 9e-22 77.0 2.4 0.0081 17.0 0.0 7.5 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AFZ80053.1 - 3.3e-13 49.7 0.0 0.043 14.1 0.0 5.4 2 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain PRP4 PF08799.11 AFZ80053.1 - 7.8e-11 41.3 0.2 1.5e-10 40.4 0.2 1.5 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like FAINT PF04385.15 AFZ80054.1 - 0.00099 19.1 0.2 0.025 14.7 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function, DUF529 MFS_1 PF07690.16 AFZ80056.1 - 3.7e-14 52.4 66.7 1.7e-11 43.6 4.8 4.2 1 1 3 4 4 4 3 Major Facilitator Superfamily GCV_T PF01571.21 AFZ80057.1 - 1.6e-40 139.1 0.0 2.3e-38 132.1 0.0 2.3 1 1 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 AFZ80057.1 - 1.5e-08 34.4 0.0 3.7e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain 7TMR-HDED PF07697.11 AFZ80057.1 - 0.02 15.0 0.2 0.036 14.2 0.2 1.4 1 0 0 1 1 1 0 7TM-HD extracellular HSP70 PF00012.20 AFZ80058.1 - 1.4e-66 224.9 14.2 4.8e-60 203.4 9.0 3.1 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 AFZ80058.1 - 5e-05 22.3 0.4 0.00015 20.7 0.4 1.8 1 1 0 1 1 1 1 MreB/Mbl protein FHA PF00498.26 AFZ80059.1 - 2e-13 50.5 0.0 8.8e-12 45.2 0.0 2.6 2 0 0 2 2 2 1 FHA domain RINGv PF12906.7 AFZ80059.1 - 7.8e-12 45.1 7.2 7.8e-12 45.1 7.2 1.9 2 0 0 2 2 2 1 RING-variant domain Yop-YscD_cpl PF16697.5 AFZ80059.1 - 5.5e-06 26.6 0.2 0.00036 20.8 0.0 2.7 3 0 0 3 3 3 1 Inner membrane component of T3SS, cytoplasmic domain FANCL_C PF11793.8 AFZ80059.1 - 0.0061 16.7 3.1 0.0061 16.7 3.1 2.3 2 0 0 2 2 2 1 FANCL C-terminal domain zf-RING_2 PF13639.6 AFZ80059.1 - 0.011 16.1 6.5 0.032 14.6 6.2 2.0 1 1 0 1 1 1 0 Ring finger domain OTCace_N PF02729.21 AFZ80060.1 - 2.6e-46 157.3 0.0 3.9e-46 156.7 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 AFZ80060.1 - 7.9e-36 123.5 0.0 1.1e-35 123.0 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain PITH PF06201.13 AFZ80061.1 - 3.5e-33 115.0 0.1 4e-33 114.8 0.1 1.0 1 0 0 1 1 1 1 PITH domain HVSL PF09749.9 AFZ80063.1 - 1e-29 103.7 0.2 2.2e-29 102.7 0.1 1.5 1 1 1 2 2 2 1 Uncharacterised conserved protein FAINT PF04385.15 AFZ80064.1 - 2.5e-08 33.9 1.0 3.7e-08 33.3 1.0 1.3 1 0 0 1 1 1 1 Domain of unknown function, DUF529 DUF5042 PF16445.5 AFZ80064.1 - 0.0028 16.1 0.1 0.0037 15.7 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF5042) FAINT PF04385.15 AFZ80065.1 - 1e-16 60.7 5.2 7.6e-05 22.7 1.8 4.0 3 1 0 3 3 3 3 Domain of unknown function, DUF529 Kinesin_assoc PF16183.5 AFZ80065.1 - 0.088 12.9 0.1 0.088 12.9 0.1 2.2 2 1 0 2 2 2 0 Kinesin-associated Nucleo_P87 PF07267.11 AFZ80065.1 - 0.24 10.2 5.7 0.43 9.4 5.7 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 MAS20 PF02064.15 AFZ80065.1 - 8.5 6.5 7.6 17 5.5 7.6 1.4 1 0 0 1 1 1 0 MAS20 protein import receptor zf-RING_11 PF17123.5 AFZ80067.1 - 0.0011 18.7 4.3 0.0046 16.7 0.6 2.7 2 1 0 2 2 2 1 RING-like zinc finger zf-ANAPC11 PF12861.7 AFZ80067.1 - 0.0064 16.5 1.7 0.0086 16.1 1.7 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger HMG_box_2 PF09011.10 AFZ80067.1 - 0.0086 16.6 1.5 0.012 16.2 1.5 1.1 1 0 0 1 1 1 1 HMG-box domain HMG_box PF00505.19 AFZ80067.1 - 0.015 15.7 1.6 0.021 15.2 1.6 1.1 1 0 0 1 1 1 0 HMG (high mobility group) box zf-RING_2 PF13639.6 AFZ80067.1 - 0.037 14.4 6.6 0.59 10.5 6.4 2.3 1 1 1 2 2 2 0 Ring finger domain zf-RING_5 PF14634.6 AFZ80067.1 - 0.1 12.6 6.4 4.9 7.2 7.0 2.3 1 1 1 2 2 2 0 zinc-RING finger domain zf-rbx1 PF12678.7 AFZ80067.1 - 0.21 11.9 7.8 0.4 11.0 6.4 2.1 1 1 1 2 2 2 0 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 AFZ80067.1 - 0.22 11.4 7.9 0.8 9.6 7.8 2.1 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AFZ80067.1 - 0.24 11.4 4.8 0.47 10.5 4.8 1.7 1 1 0 1 1 1 0 RING-type zinc-finger Thioredoxin PF00085.20 AFZ80068.1 - 2.5e-23 82.0 0.1 5.2e-23 81.0 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 AFZ80068.1 - 1.6e-06 28.5 0.2 8.5e-06 26.2 0.2 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 AFZ80068.1 - 3.7e-06 27.2 0.1 0.0011 19.2 0.1 2.4 1 1 1 2 2 2 2 Thioredoxin-like TraF PF13728.6 AFZ80068.1 - 2.3e-05 24.3 0.0 0.00038 20.4 0.0 2.0 2 0 0 2 2 2 1 F plasmid transfer operon protein AhpC-TSA PF00578.21 AFZ80068.1 - 0.00017 21.5 0.0 0.00032 20.6 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.6 AFZ80068.1 - 0.00019 21.6 0.0 0.00037 20.6 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_3 PF13192.6 AFZ80068.1 - 0.025 14.6 0.0 0.05 13.7 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin domain KaiB PF07689.12 AFZ80068.1 - 0.03 14.0 0.0 0.053 13.3 0.0 1.4 1 0 0 1 1 1 0 KaiB domain OST3_OST6 PF04756.13 AFZ80068.1 - 0.045 13.1 0.0 0.066 12.6 0.0 1.2 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family DUF836 PF05768.14 AFZ80068.1 - 0.065 13.7 0.1 0.17 12.3 0.1 1.7 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) DIM1 PF02966.16 AFZ80068.1 - 0.089 12.6 0.1 0.14 11.9 0.1 1.3 1 0 0 1 1 1 0 Mitosis protein DIM1 FAINT PF04385.15 AFZ80069.1 - 2.2e-13 50.1 3.6 1.2e-05 25.3 0.0 4.4 4 0 0 4 4 4 3 Domain of unknown function, DUF529 Pollen_allerg_1 PF01357.21 AFZ80069.1 - 0.11 12.5 0.0 0.76 9.8 0.0 2.5 3 0 0 3 3 3 0 Pollen allergen Rhomboid PF01694.22 AFZ80070.1 - 4.6e-13 49.4 4.4 6e-13 49.1 4.4 1.1 1 0 0 1 1 1 1 Rhomboid family DUF3561 PF12084.8 AFZ80074.1 - 0.00049 20.1 0.3 0.00054 19.9 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3561) FAINT PF04385.15 AFZ80075.1 - 9.5e-11 41.6 0.0 4.6e-06 26.6 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 DUF1796 PF08795.10 AFZ80078.1 - 0.035 14.1 0.8 0.061 13.3 0.8 1.4 1 0 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) Lipase_GDSL_3 PF14606.6 AFZ80078.1 - 0.14 12.3 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family IMCp PF12314.8 AFZ80079.1 - 1e-13 51.4 49.3 2e-11 44.0 23.5 2.5 1 1 1 2 2 2 2 Inner membrane complex protein Dopey_N PF04118.14 AFZ80081.1 - 1.4e-93 313.3 2.2 4.2e-93 311.8 2.2 1.9 1 0 0 1 1 1 1 Dopey, N-terminal DUF4404 PF14357.6 AFZ80081.1 - 0.085 13.5 0.5 1.5 9.5 0.1 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) PPO1_KFDV PF12143.8 AFZ80081.1 - 0.17 12.0 0.2 0.5 10.5 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF_B2219) FAINT PF04385.15 AFZ80082.1 - 0.044 13.8 0.3 0.076 13.1 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function, DUF529 Spore_III_AF PF09581.10 AFZ80083.1 - 0.0027 17.8 4.4 0.034 14.2 4.4 2.0 1 1 0 1 1 1 1 Stage III sporulation protein AF (Spore_III_AF) DUF1923 PF09083.10 AFZ80083.1 - 0.015 14.9 0.2 7.4 6.3 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1923) Bromodomain PF00439.25 AFZ80086.1 - 8.9e-21 73.8 2.2 2.1e-20 72.6 0.9 2.2 2 0 0 2 2 2 1 Bromodomain Acetyltransf_1 PF00583.25 AFZ80086.1 - 4e-12 46.4 0.1 8.7e-12 45.3 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AFZ80086.1 - 4.2e-08 33.2 0.3 1.6e-07 31.3 0.1 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AFZ80086.1 - 3.4e-07 30.6 1.1 7.5e-07 29.5 1.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AFZ80086.1 - 0.0035 17.3 0.0 0.0078 16.2 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 AFZ80086.1 - 0.0046 17.0 0.1 0.055 13.6 0.0 2.6 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain Fer2_2 PF01799.20 AFZ80088.1 - 0.056 13.5 0.2 0.092 12.8 0.2 1.4 1 1 0 1 1 1 0 [2Fe-2S] binding domain Put_DNA-bind_N PF06971.13 AFZ80090.1 - 0.16 12.0 0.3 0.67 10.0 0.0 2.3 2 0 0 2 2 2 0 Putative DNA-binding protein N-terminus FAINT PF04385.15 AFZ80091.1 - 6.2e-16 58.2 0.8 1.3e-07 31.6 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 EMA PF02488.15 AFZ80091.1 - 0.00095 18.9 1.7 0.0079 15.9 1.7 2.2 1 1 0 1 1 1 1 Merozoite Antigen CHB_HEX_C_1 PF13290.6 AFZ80092.1 - 0.0049 16.8 0.6 0.015 15.3 0.6 1.9 1 0 0 1 1 1 1 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.6 AFZ80092.1 - 0.028 14.6 1.0 0.099 12.8 0.1 2.4 2 0 0 2 2 2 0 Fn3 associated FAINT PF04385.15 AFZ80093.1 - 3.3e-09 36.7 0.0 0.0018 18.3 0.0 2.7 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ80095.1 - 6.6e-16 58.1 13.4 3.3e-07 30.3 0.3 4.9 5 0 0 5 5 5 4 Domain of unknown function, DUF529 YmzC PF14157.6 AFZ80095.1 - 0.066 13.3 0.1 0.2 11.8 0.1 1.9 1 0 0 1 1 1 0 YmzC-like protein EMA PF02488.15 AFZ80095.1 - 0.081 12.6 0.1 0.081 12.6 0.1 2.5 2 1 0 2 2 2 0 Merozoite Antigen fn3_5 PF06280.12 AFZ80095.1 - 4.5 8.0 7.0 0.54 11.0 0.2 2.8 4 0 0 4 4 4 0 Fn3-like domain RVT_1 PF00078.27 AFZ80098.1 - 4.4e-35 121.2 0.1 7.8e-35 120.4 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FAINT PF04385.15 AFZ80099.1 - 0.015 15.3 0.0 0.029 14.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function, DUF529 ABC_tran PF00005.27 AFZ80100.1 - 1.2e-31 110.1 0.0 3.7e-17 63.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_16 PF13191.6 AFZ80100.1 - 1e-05 26.0 0.0 0.18 12.2 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 AFZ80100.1 - 4e-05 23.6 0.1 0.14 12.0 0.0 3.4 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 AFZ80100.1 - 8.9e-05 22.3 0.0 0.083 12.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 AFZ80100.1 - 0.0001 22.0 1.2 0.24 11.2 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 AFZ80100.1 - 0.0003 21.4 6.4 0.53 10.8 0.5 3.4 3 0 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 AFZ80100.1 - 0.00054 19.9 0.6 0.054 13.4 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase Zeta_toxin PF06414.12 AFZ80100.1 - 0.0006 19.1 0.2 0.23 10.7 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin AAA_18 PF13238.6 AFZ80100.1 - 0.00066 20.2 0.1 2.6 8.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain DnaB_C PF03796.15 AFZ80100.1 - 0.0012 18.3 0.0 0.086 12.2 0.0 2.3 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain DUF87 PF01935.17 AFZ80100.1 - 0.0035 17.5 1.7 0.13 12.4 0.1 2.6 2 0 0 2 2 2 1 Helicase HerA, central domain FtsK_SpoIIIE PF01580.18 AFZ80100.1 - 0.0037 16.7 0.2 1.4 8.2 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family MeaB PF03308.16 AFZ80100.1 - 0.0042 16.1 0.4 0.011 14.7 0.0 1.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB SMC_N PF02463.19 AFZ80100.1 - 0.0063 16.0 0.4 0.18 11.2 0.0 2.7 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 AFZ80100.1 - 0.012 15.7 0.1 0.27 11.3 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase TrwB_AAD_bind PF10412.9 AFZ80100.1 - 0.014 14.3 0.3 4 6.2 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_22 PF13401.6 AFZ80100.1 - 0.015 15.6 0.2 3.9 7.8 0.0 2.8 2 1 0 2 2 2 0 AAA domain T2SSE PF00437.20 AFZ80100.1 - 0.025 13.6 0.7 5.8 5.9 0.1 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein cobW PF02492.19 AFZ80100.1 - 0.026 14.1 0.4 6.7 6.3 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 AFZ80100.1 - 0.037 13.9 0.5 3 7.8 0.1 2.7 2 0 0 2 2 2 0 NACHT domain NB-ARC PF00931.22 AFZ80100.1 - 0.045 12.9 0.2 1.2 8.3 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain SbcCD_C PF13558.6 AFZ80100.1 - 0.051 13.8 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit ATPase_2 PF01637.18 AFZ80100.1 - 0.072 13.0 0.1 34 4.2 0.0 3.4 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea ATP_bind_1 PF03029.17 AFZ80100.1 - 0.078 12.7 0.1 11 5.7 0.0 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 AFZ80100.1 - 0.08 13.0 0.3 7.8 6.5 0.0 2.6 2 0 0 2 2 2 0 Dynamin family AAA_25 PF13481.6 AFZ80100.1 - 0.098 12.2 0.2 1.8 8.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 AFZ80100.1 - 0.099 12.5 0.2 8.1 6.3 0.1 2.5 2 0 0 2 2 2 0 NTPase TsaE PF02367.17 AFZ80100.1 - 0.11 12.5 0.2 2.4 8.2 0.1 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_27 PF13514.6 AFZ80100.1 - 0.16 11.6 0.1 22 4.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 AFZ80100.1 - 0.35 10.5 5.0 5.5 6.6 0.1 2.8 3 0 0 3 3 3 0 AAA ATPase domain CIAPIN1 PF05093.13 AFZ80102.1 - 3.4e-20 72.4 12.9 4.6e-18 65.6 2.9 2.4 1 1 1 2 2 2 2 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis HGTP_anticodon PF03129.20 AFZ80103.1 - 1e-23 83.3 0.0 3.6e-23 81.5 0.0 2.0 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 AFZ80103.1 - 1.6e-08 34.8 0.0 5.7e-08 32.9 0.0 2.1 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) zf-DNL PF05180.12 AFZ80104.1 - 3.8e-27 94.0 1.5 3.8e-27 94.0 1.5 1.7 2 0 0 2 2 2 1 DNL zinc finger Lar_restr_allev PF14354.6 AFZ80104.1 - 0.021 15.2 2.3 0.04 14.3 0.1 2.4 2 1 0 2 2 2 0 Restriction alleviation protein Lar CGGC PF08821.11 AFZ80104.1 - 0.027 14.7 0.2 0.046 13.9 0.2 1.4 1 0 0 1 1 1 0 CGGC domain zinc_ribbon_6 PF14599.6 AFZ80104.1 - 5.4 7.1 8.4 3.4 7.8 5.0 2.3 2 1 0 2 2 2 0 Zinc-ribbon Pkinase_C PF00433.24 AFZ80105.1 - 3 8.6 5.3 2.2 9.0 1.6 2.9 2 0 0 2 2 2 0 Protein kinase C terminal domain MutS_III PF05192.18 AFZ80106.1 - 5.8e-25 88.6 0.5 4.7e-24 85.7 0.2 2.4 2 0 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 AFZ80106.1 - 4e-06 27.1 0.2 1.1e-05 25.7 0.2 1.8 1 0 0 1 1 1 1 MutS family domain IV MutS_V PF00488.21 AFZ80106.1 - 0.0002 21.4 0.1 0.00045 20.3 0.1 1.6 1 0 0 1 1 1 1 MutS domain V FAINT PF04385.15 AFZ80107.1 - 6.9e-15 54.9 3.9 2.7e-06 27.4 0.0 2.5 2 1 0 2 2 2 2 Domain of unknown function, DUF529 MutS_V PF00488.21 AFZ80108.1 - 1.7e-59 201.0 0.1 2e-59 200.8 0.1 1.0 1 0 0 1 1 1 1 MutS domain V TFIIF_beta PF02270.15 AFZ80116.1 - 0.025 14.7 0.0 0.87 9.8 0.0 2.2 2 0 0 2 2 2 0 TFIIF, beta subunit HTH domain DUF5590 PF17881.1 AFZ80117.1 - 0.044 13.9 0.9 0.43 10.7 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5590) RRM_1 PF00076.22 AFZ80117.1 - 0.17 11.8 0.0 0.44 10.4 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 AFZ80118.1 - 2.1e-05 24.2 0.0 5.3e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-Mss51 PF13824.6 AFZ80118.1 - 0.074 13.2 0.1 0.16 12.1 0.1 1.5 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 DUF1910 PF08928.10 AFZ80118.1 - 0.16 11.9 0.1 0.34 10.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1910) IPPT PF01715.17 AFZ80119.1 - 1.2e-33 116.9 1.1 1.5e-33 116.5 1.1 1.1 1 0 0 1 1 1 1 IPP transferase NOT2_3_5 PF04153.18 AFZ80119.1 - 0.048 13.7 0.2 0.097 12.8 0.2 1.5 1 0 0 1 1 1 0 NOT2 / NOT3 / NOT5 family Smoothelin PF12510.8 AFZ80119.1 - 0.071 13.2 0.5 0.19 11.8 0.5 1.8 1 0 0 1 1 1 0 Smoothelin cytoskeleton protein FAINT PF04385.15 AFZ80120.1 - 3.2e-11 43.1 0.0 2.9e-07 30.4 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 IPPT PF01715.17 AFZ80121.1 - 5e-26 91.9 0.0 2.3e-25 89.8 0.0 1.9 2 0 0 2 2 2 1 IPP transferase IPT PF01745.16 AFZ80121.1 - 0.00013 21.5 0.0 0.00019 20.9 0.0 1.2 1 0 0 1 1 1 1 Isopentenyl transferase AAA_33 PF13671.6 AFZ80121.1 - 0.0045 17.2 0.0 0.036 14.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 AFZ80121.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region FRG2 PF15315.6 AFZ80121.1 - 0.2 11.9 8.4 0.41 10.8 8.4 1.5 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 Condensin2nSMC PF12422.8 AFZ80122.1 - 0.024 14.8 0.3 0.27 11.4 0.0 2.3 2 0 0 2 2 2 0 Condensin II non structural maintenance of chromosomes subunit Muted PF14942.6 AFZ80122.1 - 0.048 14.0 18.1 0.054 13.8 4.2 3.2 3 0 0 3 3 3 0 Organelle biogenesis, Muted-like protein FAA_hydrolase_N PF09298.11 AFZ80122.1 - 0.16 12.1 2.1 0.52 10.5 0.1 2.5 2 1 1 3 3 3 0 Fumarylacetoacetase N-terminal Cas_Cas4 PF01930.17 AFZ80122.1 - 3.4 7.7 7.9 3 7.9 2.0 2.6 2 1 0 2 2 2 0 Domain of unknown function DUF83 DUF4097 PF13349.6 AFZ80123.1 - 0.014 14.8 0.8 0.029 13.7 0.8 1.5 1 0 0 1 1 1 0 Putative adhesin AARP2CN PF08142.12 AFZ80125.1 - 0.15 12.2 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 AARP2CN (NUC121) domain Vps51 PF08700.11 AFZ80127.1 - 0.016 15.3 1.4 0.092 12.8 1.4 2.4 1 0 0 1 1 1 0 Vps51/Vps67 HEAT PF02985.22 AFZ80127.1 - 0.15 12.4 3.0 43 4.8 0.0 5.5 6 0 0 6 6 6 0 HEAT repeat Cnd1 PF12717.7 AFZ80127.1 - 0.99 9.4 21.9 0.2 11.7 0.1 6.5 7 1 0 7 7 7 0 non-SMC mitotic condensation complex subunit 1 RIX1 PF08167.12 AFZ80127.1 - 2.3 7.9 7.2 12 5.6 0.1 4.9 6 0 0 6 6 6 0 rRNA processing/ribosome biogenesis Mur_ligase_M PF08245.12 AFZ80128.1 - 4.5e-05 23.5 0.1 7.2e-05 22.9 0.1 1.4 1 0 0 1 1 1 1 Mur ligase middle domain Orn_DAP_Arg_deC PF00278.22 AFZ80128.1 - 0.0049 17.1 0.0 0.015 15.5 0.0 1.8 2 0 0 2 2 2 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain ZNRF_3_ecto PF18212.1 AFZ80128.1 - 0.047 13.7 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 ZNRF-3 Ectodomain DUF3616 PF12275.8 AFZ80129.1 - 0.016 14.7 0.0 0.028 13.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3616) BNR PF02012.20 AFZ80129.1 - 0.91 9.8 3.3 4.3 7.7 0.0 3.7 4 0 0 4 4 4 0 BNR/Asp-box repeat ADH_N_assoc PF13823.6 AFZ80129.1 - 5.1 7.1 5.7 1.4 8.9 0.6 2.4 2 0 0 2 2 2 0 Alcohol dehydrogenase GroES-associated Mur_ligase_M PF08245.12 AFZ80131.1 - 0.0019 18.2 0.0 0.0026 17.8 0.0 1.2 1 0 0 1 1 1 1 Mur ligase middle domain TetR_C_5 PF08360.11 AFZ80131.1 - 0.04 14.1 0.1 0.052 13.7 0.1 1.1 1 0 0 1 1 1 0 QacR-like protein, C-terminal region SRP_TPR_like PF17004.5 AFZ80131.1 - 0.048 13.7 0.1 0.065 13.3 0.0 1.3 1 1 0 1 1 1 0 Putative TPR-like repeat Tau95 PF09734.9 AFZ80133.1 - 1.7e-28 100.2 0.0 3.2e-28 99.3 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Ephrin_rec_like PF07699.13 AFZ80134.1 - 5.7e-30 102.8 111.4 2.8e-09 36.6 3.1 12.0 12 0 0 12 12 12 10 Putative ephrin-receptor like He_PIG PF05345.12 AFZ80134.1 - 0.22 11.8 0.8 0.62 10.3 0.8 1.7 1 0 0 1 1 1 0 Putative Ig domain ABC_tran_CTD PF16326.5 AFZ80134.1 - 1.4 9.2 3.4 3.2 8.1 3.4 1.5 1 0 0 1 1 1 0 ABC transporter C-terminal domain Tmemb_cc2 PF10267.9 AFZ80135.1 - 0.13 11.4 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Ephrin_rec_like PF07699.13 AFZ80138.1 - 1.2e-32 111.4 103.3 1.1e-09 37.9 1.8 11.7 11 1 0 11 11 11 9 Putative ephrin-receptor like SirB PF04247.12 AFZ80138.1 - 1.9 8.6 9.0 0.11 12.6 1.4 2.4 2 1 0 2 2 2 0 Invasion gene expression up-regulator, SirB Med21 PF11221.8 AFZ80138.1 - 2.3 8.4 3.5 4.1 7.7 3.5 1.3 1 0 0 1 1 1 0 Subunit 21 of Mediator complex EGF_MSP1_1 PF12946.7 AFZ80138.1 - 2.9 8.0 17.9 15 5.7 0.3 6.4 6 0 0 6 6 6 0 MSP1 EGF domain 1 HCV_capsid PF01543.17 AFZ80139.1 - 0.11 12.7 0.0 0.3 11.3 0.0 1.7 1 0 0 1 1 1 0 Hepatitis C virus capsid protein LRR_9 PF14580.6 AFZ80140.1 - 2.1e-19 69.7 0.0 2.2e-19 69.6 0.0 1.0 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 AFZ80140.1 - 0.013 15.9 1.5 0.15 12.6 0.8 2.1 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) zf-C4_Topoisom PF01396.19 AFZ80142.1 - 4 7.3 5.6 0.51 10.2 0.3 2.1 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger LRR_9 PF14580.6 AFZ80143.1 - 8.4e-30 103.5 0.2 9.8e-30 103.3 0.2 1.1 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 AFZ80143.1 - 5.9e-08 32.9 3.0 0.00013 22.2 1.2 2.5 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 AFZ80143.1 - 3.2e-05 23.6 2.1 0.00034 20.3 2.3 2.4 1 1 1 2 2 2 1 Leucine rich repeat BACON PF13004.7 AFZ80147.1 - 0.041 13.9 0.1 0.22 11.5 0.1 2.3 1 0 0 1 1 1 0 Putative binding domain, N-terminal MIF4G PF02854.19 AFZ80148.1 - 3.6e-07 30.0 0.2 1e-06 28.6 0.2 1.7 1 0 0 1 1 1 1 MIF4G domain MIF4G_like_2 PF09090.11 AFZ80148.1 - 0.00013 21.6 0.2 0.00034 20.2 0.2 1.6 1 0 0 1 1 1 1 MIF4G like Syntaxin_2 PF14523.6 AFZ80150.1 - 0.017 15.5 2.1 0.017 15.5 2.1 2.7 2 1 0 2 2 2 0 Syntaxin-like protein FTP PF07504.13 AFZ80152.1 - 0.022 14.6 0.0 0.047 13.5 0.0 1.5 1 0 0 1 1 1 0 Fungalysin/Thermolysin Propeptide Motif YscK PF06578.12 AFZ80153.1 - 0.078 12.5 0.3 0.1 12.1 0.3 1.2 1 0 0 1 1 1 0 YOP proteins translocation protein K (YscK) Cys_rich_CPXG PF14255.6 AFZ80154.1 - 0.0047 16.8 1.8 0.023 14.6 0.4 2.5 3 0 0 3 3 3 1 Cysteine-rich CPXCG SFTA2 PF15210.6 AFZ80155.1 - 0.046 13.7 0.1 0.25 11.3 0.1 2.3 1 0 0 1 1 1 0 Surfactant-associated protein 2 DUF4600 PF15372.6 AFZ80155.1 - 0.058 13.8 0.9 0.15 12.5 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) UFC1 PF08694.11 AFZ80156.1 - 2.1e-76 254.8 0.1 2.4e-76 254.6 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 UQ_con PF00179.26 AFZ80156.1 - 0.0058 16.3 0.1 0.014 15.1 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 AFZ80156.1 - 0.08 13.2 0.0 0.099 12.9 0.0 1.1 1 0 0 1 1 1 0 RWD domain Pox_P4B PF03292.14 AFZ80156.1 - 0.26 9.5 0.0 0.33 9.2 0.0 1.1 1 0 0 1 1 1 0 Poxvirus P4B major core protein Hydrolase_3 PF08282.12 AFZ80157.1 - 9.7e-27 94.3 0.0 5.9e-16 59.0 0.0 2.1 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AFZ80157.1 - 0.0086 16.4 0.0 3.4 7.9 0.0 2.5 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 AFZ80157.1 - 0.041 14.3 0.0 2.3 8.6 0.0 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase SRP-alpha_N PF04086.13 AFZ80158.1 - 1.2 9.0 7.9 2.2 8.1 7.9 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal TBP PF00352.21 AFZ80159.1 - 6.1e-24 83.8 0.9 4.4e-09 36.2 0.0 4.2 3 1 0 3 3 3 3 Transcription factor TFIID (or TATA-binding protein, TBP) RF-1 PF00472.20 AFZ80160.1 - 0.00011 22.1 4.6 0.00014 21.7 4.6 1.1 1 0 0 1 1 1 1 RF-1 domain VPS28 PF03997.12 AFZ80160.1 - 0.0066 16.1 0.5 0.0091 15.7 0.5 1.1 1 0 0 1 1 1 1 VPS28 protein MMTV_SAg PF01054.17 AFZ80160.1 - 0.041 13.4 0.2 0.048 13.2 0.2 1.1 1 0 0 1 1 1 0 Mouse mammary tumour virus superantigen PCRF PF03462.18 AFZ80162.1 - 1.2e-17 64.5 0.0 2e-17 63.7 0.0 1.4 1 0 0 1 1 1 1 PCRF domain RF-1 PF00472.20 AFZ80162.1 - 8.2e-17 61.2 0.0 1.3e-16 60.5 0.0 1.3 1 0 0 1 1 1 1 RF-1 domain Pkinase PF00069.25 AFZ80163.1 - 1.3e-11 44.4 1.5 4.9e-10 39.2 0.1 3.0 2 1 0 3 3 3 1 Protein kinase domain RWD PF05773.22 AFZ80163.1 - 2.3e-08 34.3 0.2 2.3e-08 34.3 0.2 2.6 2 2 0 2 2 2 1 RWD domain Pkinase_Tyr PF07714.17 AFZ80163.1 - 0.00091 18.6 0.2 0.0025 17.1 0.2 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase UQ_con PF00179.26 AFZ80163.1 - 0.051 13.2 0.1 0.31 10.7 0.0 2.4 3 0 0 3 3 3 0 Ubiquitin-conjugating enzyme SPC12 PF06645.13 AFZ80165.1 - 1.2e-10 41.3 6.5 1.4e-10 41.1 6.5 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) zf-HIT PF04438.16 AFZ80167.1 - 0.031 14.2 0.5 0.061 13.2 0.5 1.4 1 0 0 1 1 1 0 HIT zinc finger IR1-M PF12185.8 AFZ80168.1 - 0.032 14.1 0.0 0.073 13.0 0.0 1.5 1 0 0 1 1 1 0 Nup358/RanBP2 E3 ligase domain ABC_tran PF00005.27 AFZ80169.1 - 1.1e-28 100.4 0.0 1.4e-15 58.0 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_16 PF13191.6 AFZ80169.1 - 1.8e-05 25.2 0.0 0.21 11.9 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.6 AFZ80169.1 - 7.6e-05 22.5 0.1 0.15 11.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 AFZ80169.1 - 0.00024 20.8 1.2 0.11 12.2 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 AFZ80169.1 - 0.00055 19.9 0.6 0.16 11.8 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase Zeta_toxin PF06414.12 AFZ80169.1 - 0.0026 17.1 0.4 0.71 9.1 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin Fer4_NifH PF00142.18 AFZ80169.1 - 0.0084 15.6 0.3 1.3 8.5 0.0 2.3 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family DnaB_C PF03796.15 AFZ80169.1 - 0.014 14.8 0.0 0.68 9.2 0.0 2.2 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain VraX PF17412.2 AFZ80169.1 - 0.017 14.7 0.1 0.063 12.9 0.1 1.9 1 0 0 1 1 1 0 Family of unknown function MeaB PF03308.16 AFZ80169.1 - 0.018 14.0 0.6 0.069 12.1 0.1 1.9 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_23 PF13476.6 AFZ80169.1 - 0.026 15.0 8.9 0.63 10.5 0.7 2.6 3 0 0 3 3 2 0 AAA domain MMR_HSR1 PF01926.23 AFZ80169.1 - 0.027 14.6 0.1 0.42 10.7 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 AFZ80169.1 - 0.034 13.5 0.4 7.5 5.8 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_22 PF13401.6 AFZ80169.1 - 0.035 14.4 0.3 10 6.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 AFZ80169.1 - 0.053 13.6 2.8 0.11 12.6 0.1 2.6 3 0 0 3 3 3 0 Helicase HerA, central domain TrwB_AAD_bind PF10412.9 AFZ80169.1 - 0.059 12.3 0.3 3.3 6.5 0.1 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain ATP_bind_1 PF03029.17 AFZ80169.1 - 0.063 13.0 0.2 3.7 7.3 0.0 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 AFZ80169.1 - 0.095 13.3 0.1 14 6.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain P3A PF08727.11 AFZ80169.1 - 0.098 12.0 0.1 0.32 10.4 0.1 1.8 1 0 0 1 1 1 0 Poliovirus 3A protein like T2SSE PF00437.20 AFZ80169.1 - 0.14 11.2 1.0 4.5 6.3 0.1 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein SMC_N PF02463.19 AFZ80169.1 - 0.17 11.3 1.1 2.5 7.5 0.1 2.4 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain NTPase_1 PF03266.15 AFZ80169.1 - 0.21 11.5 0.5 14 5.5 0.2 2.4 2 0 0 2 2 2 0 NTPase AAA_21 PF13304.6 AFZ80169.1 - 0.57 9.9 2.2 14 5.4 0.0 3.0 4 0 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system FAINT PF04385.15 AFZ80170.1 - 3.3e-75 248.2 89.4 9e-07 28.9 4.7 21.3 20 0 0 20 20 20 20 Domain of unknown function, DUF529 Viral_P18 PF04521.13 AFZ80170.1 - 0.0055 16.5 0.0 0.015 15.1 0.0 1.7 1 0 0 1 1 1 1 ssRNA positive strand viral 18kD cysteine rich protein TPR_2 PF07719.17 AFZ80172.1 - 8.9e-15 53.6 0.0 0.0026 17.7 0.0 5.5 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 AFZ80172.1 - 6.3e-14 51.1 0.0 0.0014 18.3 0.0 5.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 AFZ80172.1 - 6e-11 41.7 0.0 0.055 13.7 0.0 5.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 AFZ80172.1 - 3.5e-09 37.0 0.1 0.00054 20.4 0.0 3.6 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 AFZ80172.1 - 2.6e-08 34.0 0.1 0.52 11.3 0.0 4.8 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 AFZ80172.1 - 1.8e-06 28.5 0.0 0.14 12.9 0.0 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 AFZ80172.1 - 6.5e-06 25.7 0.0 0.18 11.5 0.0 3.4 3 1 1 4 4 4 2 TPR repeat TPR_12 PF13424.6 AFZ80172.1 - 2.7e-05 24.4 0.2 0.0046 17.2 0.0 3.3 2 1 1 3 3 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 AFZ80172.1 - 0.00037 20.6 1.0 0.0059 16.8 0.0 3.0 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 AFZ80172.1 - 0.00042 20.4 0.0 0.0052 16.9 0.0 2.6 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 AFZ80172.1 - 0.011 15.8 0.0 0.24 11.5 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 AFZ80172.1 - 0.031 14.1 0.0 0.13 12.1 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 AFZ80172.1 - 0.033 14.8 0.0 0.59 10.9 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 AFZ80172.1 - 0.068 13.6 0.3 7.6 7.2 0.0 3.8 4 0 0 4 4 3 0 Tetratricopeptide repeat Clathrin PF00637.20 AFZ80172.1 - 0.13 12.1 1.2 0.48 10.3 0.1 2.5 2 1 1 3 3 3 0 Region in Clathrin and VPS BTAD PF03704.17 AFZ80172.1 - 0.14 12.6 0.0 0.44 11.0 0.0 1.8 1 0 0 1 1 1 0 Bacterial transcriptional activator domain Ribosomal_S15 PF00312.22 AFZ80173.1 - 4.4e-20 71.7 0.3 7.8e-20 70.9 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein S15 zf-CHC2 PF01807.20 AFZ80175.1 - 0.12 12.2 0.1 0.41 10.5 0.0 1.9 2 0 0 2 2 2 0 CHC2 zinc finger zinc_ribbon_10 PF10058.9 AFZ80175.1 - 0.55 10.0 3.0 16 5.3 0.1 2.5 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Ribosomal_L6 PF00347.23 AFZ80176.1 - 1.5e-22 80.1 4.1 7.2e-13 49.0 0.1 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 Carb_anhydrase PF00194.21 AFZ80176.1 - 0.11 12.0 0.0 0.13 11.8 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic-type carbonic anhydrase FAINT PF04385.15 AFZ80180.1 - 1.1e-07 31.8 4.4 0.00019 21.4 0.8 2.5 2 1 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ80182.1 - 7.9e-35 118.8 16.5 3.6e-07 30.1 0.1 6.4 6 0 0 6 6 6 6 Domain of unknown function, DUF529 AviRa PF11599.8 AFZ80182.1 - 0.038 13.4 1.0 0.064 12.7 0.1 1.8 2 0 0 2 2 2 0 RRNA methyltransferase AviRa HEAT PF02985.22 AFZ80185.1 - 0.0065 16.6 0.5 35 5.0 0.0 3.9 3 0 0 3 3 3 3 HEAT repeat Asn_synthase PF00733.21 AFZ80186.1 - 2.3e-12 47.3 2.5 0.00044 20.0 0.0 3.4 2 1 1 3 3 3 3 Asparagine synthase Arginase PF00491.21 AFZ80186.1 - 0.038 13.5 0.0 0.07 12.6 0.0 1.3 1 0 0 1 1 1 0 Arginase family GATase_7 PF13537.6 AFZ80186.1 - 0.042 13.8 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Glutamine amidotransferase domain Fib_alpha PF08702.10 AFZ80187.1 - 0.2 11.8 3.6 0.58 10.3 3.6 1.8 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF3053 PF11254.8 AFZ80187.1 - 5.8 6.4 8.8 1 8.9 0.6 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3053) MFS_1 PF07690.16 AFZ80189.1 - 6.1e-18 64.9 12.1 9.7e-18 64.2 12.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily TetR_C_36 PF18598.1 AFZ80189.1 - 0.19 11.7 0.1 0.34 10.9 0.1 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Wbp11 PF09429.10 AFZ80192.1 - 2.7e-08 34.1 13.6 4e-08 33.5 13.6 1.2 1 0 0 1 1 1 1 WW domain binding protein 11 YPEB PF14620.6 AFZ80192.1 - 0.22 10.8 1.4 0.3 10.4 1.4 1.1 1 0 0 1 1 1 0 YpeB sporulation PIN_12 PF16289.5 AFZ80192.1 - 1.2 9.7 4.6 1.7 9.1 4.6 1.2 1 0 0 1 1 1 0 PIN domain zf-C4H2 PF10146.9 AFZ80192.1 - 2.9 8.1 11.0 5.4 7.3 10.8 1.6 1 1 0 1 1 1 0 Zinc finger-containing protein F5_F8_type_C PF00754.25 AFZ80193.1 - 0.057 13.5 0.4 0.34 11.1 0.0 2.4 3 0 0 3 3 3 0 F5/8 type C domain SSURE PF11966.8 AFZ80193.1 - 0.67 9.7 5.5 6.2 6.7 0.0 4.1 5 0 0 5 5 5 0 Fibronectin-binding repeat LRR_9 PF14580.6 AFZ80194.1 - 8e-13 48.2 0.6 3.3e-12 46.3 0.6 1.7 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 AFZ80194.1 - 1.6e-09 37.9 7.4 1.1e-05 25.7 2.8 3.8 2 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 AFZ80194.1 - 1.8e-07 30.8 2.9 0.0038 16.9 1.8 3.8 3 1 0 3 3 3 2 Leucine rich repeat LRR_6 PF13516.6 AFZ80194.1 - 0.00078 19.3 0.3 4.5 7.6 0.0 4.1 4 0 0 4 4 4 2 Leucine Rich repeat LRR_1 PF00560.33 AFZ80194.1 - 0.04 14.5 2.9 26 5.9 0.0 4.2 5 0 0 5 5 5 0 Leucine Rich Repeat SDA1 PF05285.12 AFZ80194.1 - 4.2 6.7 21.3 5.4 6.4 21.3 1.1 1 0 0 1 1 1 0 SDA1 RNase_PH PF01138.21 AFZ80195.1 - 5.8e-14 52.7 0.1 1.1e-13 51.8 0.1 1.5 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 DUF3458_C PF17432.2 AFZ80197.1 - 1.3e-90 304.0 0.3 1.8e-90 303.6 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3458_C) ARM repeats Peptidase_M1 PF01433.20 AFZ80197.1 - 1.9e-49 168.2 0.3 3.1e-49 167.5 0.3 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain DUF3458 PF11940.8 AFZ80197.1 - 1.1e-20 73.8 0.0 2.4e-20 72.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3458) Ig-like fold Peptidase_M1_N PF17900.1 AFZ80197.1 - 4.6e-12 46.5 0.0 9.8e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M61 PF05299.12 AFZ80197.1 - 0.058 13.8 0.0 0.15 12.5 0.0 1.7 1 0 0 1 1 1 0 M61 glycyl aminopeptidase Exo_endo_phos PF03372.23 AFZ80198.1 - 4.4e-05 23.1 0.0 8.5e-05 22.2 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family GP46 PF07409.12 AFZ80198.1 - 0.13 12.0 0.1 0.26 11.0 0.1 1.4 1 0 0 1 1 1 0 Phage protein GP46 Snf7 PF03357.21 AFZ80199.1 - 0.0052 16.4 5.3 0.0061 16.2 5.3 1.2 1 0 0 1 1 1 1 Snf7 FbpA PF05833.11 AFZ80199.1 - 0.01 14.6 7.4 0.0091 14.8 6.2 1.4 1 1 1 2 2 2 0 Fibronectin-binding protein A N-terminus (FbpA) DUF4515 PF14988.6 AFZ80199.1 - 0.087 12.7 11.0 0.074 12.9 9.3 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4515) ICA69 PF04629.14 AFZ80199.1 - 0.09 13.1 1.2 0.11 12.7 1.2 1.1 1 0 0 1 1 1 0 Islet cell autoantigen ICA69, C-terminal domain YusW PF14039.6 AFZ80199.1 - 0.13 12.8 5.5 2.3 8.8 2.1 2.4 1 1 0 2 2 2 0 YusW-like protein RNB PF00773.19 AFZ80200.1 - 1.2e-82 277.9 0.3 1.9e-82 277.2 0.3 1.3 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 AFZ80200.1 - 0.0011 18.9 0.0 0.0024 17.8 0.0 1.6 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 AFZ80200.1 - 0.0014 18.7 0.0 0.0042 17.2 0.0 1.9 1 0 0 1 1 1 1 Cold shock domain Ribosomal_L34 PF00468.17 AFZ80200.1 - 0.013 15.5 0.1 0.026 14.5 0.1 1.5 1 0 0 1 1 1 0 Ribosomal protein L34 Coatomer_WDAD PF04053.14 AFZ80201.1 - 6.5e-107 358.3 0.1 4.4e-106 355.6 0.0 2.0 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 AFZ80201.1 - 6.8e-23 80.5 13.7 8.2e-07 29.6 0.4 7.8 7 0 0 7 7 7 5 WD domain, G-beta repeat Ribosomal_L35p PF01632.19 AFZ80202.1 - 2.6e-10 40.6 12.8 5.9e-10 39.5 12.8 1.6 1 0 0 1 1 1 1 Ribosomal protein L35 Med26 PF08711.11 AFZ80204.1 - 4.7e-10 39.3 0.0 9.5e-10 38.3 0.0 1.5 1 0 0 1 1 1 1 TFIIS helical bundle-like domain SHMT PF00464.19 AFZ80205.1 - 2.9e-170 566.2 0.0 3.5e-170 565.9 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase DUF1929 PF09118.11 AFZ80205.1 - 0.0052 17.0 0.0 2.2 8.6 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF1929) Aminotran_1_2 PF00155.21 AFZ80205.1 - 0.012 14.8 0.0 0.03 13.5 0.0 1.6 2 0 0 2 2 2 0 Aminotransferase class I and II ATP-synt_ab PF00006.25 AFZ80206.1 - 1.6e-63 214.2 0.0 2.4e-63 213.6 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 AFZ80206.1 - 6.3e-18 65.1 0.1 1.5e-17 63.9 0.1 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain AAA PF00004.29 AFZ80206.1 - 0.017 15.5 0.2 1 9.8 0.1 2.9 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 AFZ80206.1 - 0.018 14.2 0.2 0.037 13.2 0.2 1.5 1 0 0 1 1 1 0 NB-ARC domain RsgA_GTPase PF03193.16 AFZ80206.1 - 0.023 14.6 0.1 0.045 13.7 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase ATPase PF06745.13 AFZ80206.1 - 0.03 13.7 0.8 0.054 12.8 0.8 1.4 1 0 0 1 1 1 0 KaiC ATPase_2 PF01637.18 AFZ80206.1 - 0.05 13.5 0.2 0.098 12.6 0.0 1.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_16 PF13191.6 AFZ80206.1 - 0.054 13.9 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 AFZ80206.1 - 0.078 12.9 0.1 0.41 10.5 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_19 PF13245.6 AFZ80206.1 - 0.24 11.7 1.2 0.41 11.0 0.3 1.7 2 0 0 2 2 2 0 AAA domain MA3 PF02847.17 AFZ80207.1 - 5.9e-14 52.0 0.1 2.4e-13 50.0 0.1 2.2 1 0 0 1 1 1 1 MA3 domain MIF4G PF02854.19 AFZ80207.1 - 3.7e-07 30.0 2.9 9.9e-07 28.6 2.9 1.8 1 0 0 1 1 1 1 MIF4G domain DNA_pol_A PF00476.20 AFZ80208.1 - 2.7e-85 286.7 0.7 5.2e-85 285.8 0.7 1.5 1 0 0 1 1 1 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.20 AFZ80208.1 - 1.6e-30 106.1 0.1 4.4e-30 104.7 0.0 1.8 2 0 0 2 2 2 1 3'-5' exonuclease AAA_25 PF13481.6 AFZ80208.1 - 3.6e-27 95.2 0.0 6.7e-27 94.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 AFZ80208.1 - 8.3e-06 25.3 0.0 2.8e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 KaiC DnaB_C PF03796.15 AFZ80208.1 - 1.2e-05 24.7 0.0 9e-05 21.9 0.0 2.3 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain Toprim_2 PF13155.6 AFZ80208.1 - 3e-05 24.4 0.0 8.3e-05 22.9 0.0 1.9 1 0 0 1 1 1 1 Toprim-like AAA_22 PF13401.6 AFZ80208.1 - 0.00042 20.6 0.0 0.002 18.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain Toprim_3 PF13362.6 AFZ80208.1 - 0.017 15.5 0.0 0.06 13.7 0.0 2.0 2 0 0 2 2 1 0 Toprim domain RNase_H_2 PF13482.6 AFZ80208.1 - 0.025 14.6 0.0 0.074 13.0 0.0 1.8 1 0 0 1 1 1 0 RNase_H superfamily Toprim_4 PF13662.6 AFZ80208.1 - 0.027 14.9 0.0 0.29 11.6 0.0 2.8 2 1 0 2 2 2 0 Toprim domain AAA_16 PF13191.6 AFZ80208.1 - 0.056 13.8 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 AFZ80208.1 - 0.057 13.9 0.6 0.88 10.1 0.0 2.8 2 0 0 2 2 2 0 ABC transporter LRRNT PF01462.18 AFZ80208.1 - 0.11 12.2 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain Rhomboid PF01694.22 AFZ80210.1 - 4.1e-10 39.9 13.9 4.1e-10 39.9 13.9 1.7 2 0 0 2 2 2 1 Rhomboid family Peptidase_S39 PF02122.15 AFZ80211.1 - 0.088 12.3 0.1 0.17 11.4 0.1 1.4 1 0 0 1 1 1 0 Peptidase S39 Asp_Glu_race PF01177.22 AFZ80211.1 - 0.18 11.6 0.0 0.32 10.8 0.0 1.3 1 0 0 1 1 1 0 Asp/Glu/Hydantoin racemase FAINT PF04385.15 AFZ80212.1 - 0.025 14.6 0.0 0.036 14.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function, DUF529 dUTPase PF00692.19 AFZ80213.1 - 4.8e-19 68.3 0.0 1.4e-18 66.8 0.0 1.6 1 1 0 1 1 1 1 dUTPase Methyltransf_4 PF02390.17 AFZ80214.1 - 1.2e-44 151.8 0.0 1.5e-44 151.5 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Acatn PF13000.7 AFZ80214.1 - 0.006 15.1 0.1 0.0077 14.8 0.1 1.1 1 0 0 1 1 1 1 Acetyl-coenzyme A transporter 1 Methyltransf_25 PF13649.6 AFZ80214.1 - 0.0082 16.8 0.0 0.02 15.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 AFZ80214.1 - 0.011 15.3 0.0 0.036 13.6 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_23 PF13489.6 AFZ80214.1 - 0.04 13.7 0.0 0.056 13.3 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 AFZ80214.1 - 0.15 11.9 0.1 0.43 10.4 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain LSM PF01423.22 AFZ80215.1 - 1.5e-17 63.0 0.0 1.8e-17 62.8 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 AFZ80215.1 - 2.7e-06 27.4 0.0 3.3e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain Hfq PF17209.3 AFZ80215.1 - 0.052 13.2 0.0 0.087 12.5 0.0 1.4 2 0 0 2 2 2 0 Hfq protein Helicase_C PF00271.31 AFZ80217.1 - 7.7e-23 81.0 0.8 2.1e-22 79.6 0.8 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 AFZ80217.1 - 5.1e-21 75.2 0.0 3.9e-19 69.1 0.0 2.6 2 1 1 3 3 3 2 DEAD/DEAH box helicase Sec23_trunk PF04811.15 AFZ80218.1 - 2e-25 89.8 0.2 3.5e-25 89.0 0.2 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 AFZ80218.1 - 2.7e-16 60.1 0.1 1.1e-14 54.9 0.0 2.7 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 AFZ80218.1 - 7.4e-09 35.4 0.1 5e-08 32.7 0.1 2.5 2 0 0 2 2 2 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 AFZ80218.1 - 6.8e-06 26.0 3.9 6.8e-06 26.0 3.9 3.5 4 0 0 4 4 4 2 Sec23/Sec24 zinc finger Gelsolin PF00626.22 AFZ80218.1 - 0.00027 20.8 0.1 0.00067 19.5 0.1 1.6 1 0 0 1 1 1 1 Gelsolin repeat FYVE PF01363.21 AFZ80218.1 - 0.36 11.0 2.8 1.3 9.2 2.8 2.0 1 0 0 1 1 1 0 FYVE zinc finger Jiv90 PF14901.6 AFZ80218.1 - 0.79 9.9 3.0 1.6 8.9 3.0 1.5 1 0 0 1 1 1 0 Cleavage inducing molecular chaperone DUF349 PF03993.12 AFZ80220.1 - 0.77 10.1 7.4 1.8 8.9 6.8 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) Ribosomal_L13 PF00572.18 AFZ80221.1 - 2e-30 105.6 0.1 2.6e-30 105.2 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 Ubiquitin_2 PF14560.6 AFZ80222.1 - 7e-19 68.1 0.9 1.2e-18 67.3 0.1 1.8 2 1 0 2 2 2 1 Ubiquitin-like domain CAP_GLY PF01302.25 AFZ80222.1 - 1.1e-13 51.0 1.2 1.7e-13 50.4 1.2 1.3 1 0 0 1 1 1 1 CAP-Gly domain Peptidase_A3 PF02160.15 AFZ80222.1 - 0.027 13.9 0.0 0.046 13.2 0.0 1.4 1 0 0 1 1 1 0 Cauliflower mosaic virus peptidase (A3) DUF4994 PF16385.5 AFZ80222.1 - 0.058 13.3 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function ubiquitin PF00240.23 AFZ80222.1 - 0.12 12.1 0.0 2.8 7.8 0.0 2.4 2 0 0 2 2 2 0 Ubiquitin family Methyltrn_RNA_3 PF02598.17 AFZ80223.1 - 5.8e-80 268.8 0.0 7.5e-80 268.5 0.0 1.1 1 0 0 1 1 1 1 Putative RNA methyltransferase BHD_1 PF10403.9 AFZ80224.1 - 2.8e-06 27.1 0.3 9.3e-06 25.4 0.0 2.1 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 1 BHD_3 PF10405.9 AFZ80224.1 - 1.7e-05 25.2 0.1 7.6e-05 23.0 0.0 2.2 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 3 Rad4 PF03835.15 AFZ80224.1 - 0.00042 20.0 0.1 0.0055 16.4 0.0 2.2 2 0 0 2 2 2 1 Rad4 transglutaminase-like domain Phage_FRD3 PF05798.11 AFZ80224.1 - 0.089 13.1 0.0 0.26 11.6 0.0 1.8 1 0 0 1 1 1 0 Bacteriophage FRD3 protein zf-SNAP50_C PF12251.8 AFZ80225.1 - 0.009 15.7 0.0 0.0093 15.7 0.0 1.0 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal zf-C6H2 PF15801.5 AFZ80226.1 - 1.9e-07 31.2 14.8 3.4e-07 30.5 14.8 1.3 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding Sigma_reg_N PF13800.6 AFZ80226.1 - 0.017 15.4 0.5 0.055 13.8 0.5 1.9 1 0 0 1 1 1 0 Sigma factor regulator N-terminal CDP-OH_P_transf PF01066.21 AFZ80226.1 - 0.15 12.8 0.0 0.25 12.2 0.0 1.4 1 0 0 1 1 1 0 CDP-alcohol phosphatidyltransferase Peptidase_M24 PF00557.24 AFZ80227.1 - 1.4e-24 86.9 0.0 2e-24 86.5 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 IMPDH PF00478.25 AFZ80228.1 - 7.1e-57 193.0 0.1 1.7e-56 191.7 0.1 1.5 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 AFZ80228.1 - 1.8e-06 27.3 0.1 9.5e-06 24.9 0.1 1.9 2 0 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 AFZ80228.1 - 0.01 15.3 0.8 0.039 13.4 0.2 2.2 3 1 0 3 3 3 0 Histidine biosynthesis protein NMO PF03060.15 AFZ80228.1 - 0.031 13.7 0.1 0.054 12.9 0.1 1.4 1 0 0 1 1 1 0 Nitronate monooxygenase Glu_synthase PF01645.17 AFZ80228.1 - 0.081 12.1 0.1 0.17 10.9 0.1 1.5 1 0 0 1 1 1 0 Conserved region in glutamate synthase Inhibitor_G39P PF11417.8 AFZ80229.1 - 0.1 13.2 0.4 21 5.7 0.0 3.4 4 0 0 4 4 4 0 Loader and inhibitor of phage G40P RAP PF08373.10 AFZ80230.1 - 2.3e-07 30.8 6.5 2.4e-07 30.8 1.1 2.2 2 0 0 2 2 2 2 RAP domain RabGAP-TBC PF00566.18 AFZ80231.1 - 8.5e-55 185.7 2.7 1.5e-54 184.9 2.7 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Pkinase PF00069.25 AFZ80232.1 - 6.6e-62 209.3 0.0 4.7e-39 134.3 0.0 3.1 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ80232.1 - 7.8e-29 100.7 0.0 1.5e-23 83.5 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 AFZ80232.1 - 0.0092 15.4 0.0 0.017 14.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 AFZ80232.1 - 0.017 14.1 2.1 0.016 14.2 0.5 1.9 2 1 0 2 2 2 0 Haspin like kinase domain Kinase-like PF14531.6 AFZ80232.1 - 0.058 12.7 0.0 1.8 7.8 0.0 2.2 2 0 0 2 2 2 0 Kinase-like WD40 PF00400.32 AFZ80233.1 - 2.7e-06 28.0 9.3 0.002 18.9 0.6 5.3 5 0 0 5 5 5 2 WD domain, G-beta repeat Med21 PF11221.8 AFZ80234.1 - 7.4e-07 29.5 0.4 8.8e-07 29.3 0.4 1.2 1 0 0 1 1 1 1 Subunit 21 of Mediator complex Tn7_Tnp_TnsA_C PF08721.11 AFZ80234.1 - 0.058 14.0 0.3 0.13 13.0 0.3 1.6 1 0 0 1 1 1 0 TnsA endonuclease C terminal Actin PF00022.19 AFZ80235.1 - 2.5e-58 197.6 0.0 4.9e-56 190.1 0.0 2.0 1 1 0 1 1 1 1 Actin MFS_1 PF07690.16 AFZ80237.1 - 2.6e-17 62.8 11.0 4.8e-17 61.9 11.0 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily Ribosomal_L5_C PF00673.21 AFZ80238.1 - 7.7e-23 80.5 0.0 1.1e-22 80.0 0.0 1.2 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 AFZ80238.1 - 1.4e-17 63.7 0.0 2.4e-17 63.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 ACT_5 PF13710.6 AFZ80238.1 - 0.061 13.2 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 ACT domain Ribosomal_S13 PF00416.22 AFZ80239.1 - 5.1e-50 169.1 2.6 6e-50 168.9 2.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 AFZ80239.1 - 0.0072 15.1 0.0 0.0081 15.0 0.0 1.2 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) DUF2746 PF10874.8 AFZ80239.1 - 0.022 15.2 0.0 0.037 14.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2746) RAP PF08373.10 AFZ80241.1 - 0.0035 17.4 0.8 0.013 15.5 0.8 2.1 1 1 0 1 1 1 1 RAP domain E1_FCCH PF16190.5 AFZ80241.1 - 0.1 12.8 0.1 0.23 11.7 0.1 1.5 1 0 0 1 1 1 0 Ubiquitin-activating enzyme E1 FCCH domain Na_Ala_symp PF01235.17 AFZ80242.1 - 0.11 11.7 0.0 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 Sodium:alanine symporter family ING PF12998.7 AFZ80243.1 - 6.6e-08 33.1 0.9 4.7e-05 23.9 0.0 2.3 1 1 1 2 2 2 2 Inhibitor of growth proteins N-terminal histone-binding HALZ PF02183.18 AFZ80243.1 - 0.077 13.2 0.1 0.19 11.9 0.1 1.7 1 0 0 1 1 1 0 Homeobox associated leucine zipper SBDS_C PF09377.10 AFZ80244.1 - 1.1e-28 99.5 0.1 2.7e-28 98.3 0.1 1.7 1 0 0 1 1 1 1 SBDS protein C-terminal domain SBDS PF01172.18 AFZ80244.1 - 6.9e-28 96.6 0.9 1.8e-27 95.2 0.9 1.8 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein DUF3896 PF13035.6 AFZ80245.1 - 1.9 8.7 4.4 2.3 8.4 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3896) GTP_EFTU PF00009.27 AFZ80246.1 - 6.8e-52 175.8 0.0 9.6e-52 175.3 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 AFZ80246.1 - 1.5e-15 57.0 0.0 2.7e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 AFZ80246.1 - 3e-09 36.9 0.0 5.8e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 AFZ80246.1 - 4.3e-05 23.6 0.0 0.0001 22.4 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RF3_C PF16658.5 AFZ80246.1 - 0.011 15.5 0.0 0.023 14.5 0.0 1.4 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain AIG1 PF04548.16 AFZ80246.1 - 0.011 15.1 0.0 0.32 10.3 0.0 2.3 2 0 0 2 2 2 0 AIG1 family Phi29_Phage_SSB PF17427.2 AFZ80246.1 - 0.084 13.1 0.0 0.28 11.4 0.0 1.9 1 0 0 1 1 1 0 Phage Single-stranded DNA-binding protein DUF1732 PF08340.11 AFZ80246.1 - 0.12 12.3 0.0 4.9 7.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1732) zf-RING_4 PF14570.6 AFZ80247.1 - 5e-20 71.0 12.2 1.2e-19 69.9 12.2 1.7 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 AFZ80247.1 - 1.5e-08 34.3 7.4 3.2e-08 33.3 7.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.22 AFZ80247.1 - 3.3e-05 23.6 0.0 6.8e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RING_2 PF13639.6 AFZ80247.1 - 0.0047 17.2 9.8 0.0047 17.2 9.8 2.3 2 0 0 2 2 2 1 Ring finger domain Torus PF16131.5 AFZ80247.1 - 0.016 15.9 2.0 0.016 15.9 2.0 2.5 3 0 0 3 3 2 0 Torus domain Prok-RING_4 PF14447.6 AFZ80247.1 - 0.019 14.8 7.4 0.81 9.6 6.6 2.6 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Nup35_RRM_2 PF14605.6 AFZ80247.1 - 0.021 14.8 0.2 0.042 13.9 0.2 1.6 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Rad50_zn_hook PF04423.14 AFZ80247.1 - 0.034 14.0 2.0 0.92 9.4 0.2 3.1 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-UDP PF14569.6 AFZ80247.1 - 0.038 14.1 4.7 0.086 13.0 4.7 1.6 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-C3HC4 PF00097.25 AFZ80247.1 - 0.051 13.5 9.4 0.11 12.3 9.4 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.12 AFZ80247.1 - 0.065 12.6 3.2 0.13 11.6 3.2 1.5 1 0 0 1 1 1 0 Rtf2 RING-finger Myb_CC_LHEQLE PF14379.6 AFZ80247.1 - 0.41 10.4 4.2 0.76 9.5 4.2 1.4 1 0 0 1 1 1 0 MYB-CC type transfactor, LHEQLE motif YebO PF13974.6 AFZ80247.1 - 0.51 10.4 2.0 13 5.9 1.6 2.7 2 0 0 2 2 2 0 YebO-like protein zf-C3HC4_2 PF13923.6 AFZ80247.1 - 0.84 9.5 10.0 2.2 8.2 10.0 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-ZPR1 PF03367.13 AFZ80248.1 - 3.7e-87 290.1 1.6 6.3e-44 149.6 1.1 2.2 2 0 0 2 2 2 2 ZPR1 zinc-finger domain Zn-ribbon_8 PF09723.10 AFZ80248.1 - 0.02 15.0 5.0 12 6.1 0.0 4.0 4 0 0 4 4 4 0 Zinc ribbon domain ThylakoidFormat PF11264.8 AFZ80248.1 - 0.044 13.5 0.0 0.096 12.4 0.0 1.5 1 0 0 1 1 1 0 Thylakoid formation protein RNHCP PF12647.7 AFZ80248.1 - 0.16 11.9 3.5 18 5.4 0.0 3.4 3 1 0 3 3 3 0 RNHCP domain RNA_POL_M_15KD PF02150.16 AFZ80248.1 - 0.18 11.7 3.4 2.6 8.0 0.0 3.3 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit zf-DNL PF05180.12 AFZ80248.1 - 0.26 11.2 1.6 17 5.5 0.0 3.3 3 0 0 3 3 3 0 DNL zinc finger Rubredoxin PF00301.20 AFZ80248.1 - 0.66 10.1 3.3 38 4.4 0.1 3.3 3 0 0 3 3 3 0 Rubredoxin Sgf11 PF08209.11 AFZ80248.1 - 1.8 8.2 6.6 17 5.1 0.1 3.2 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) DUF2428 PF10350.9 AFZ80249.1 - 1.4e-25 90.1 0.8 3.9e-25 88.7 0.2 2.1 2 0 0 2 2 2 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 AFZ80249.1 - 0.022 15.0 1.7 10 6.7 0.0 3.8 3 0 0 3 3 3 0 HEAT repeat DHHC PF01529.20 AFZ80251.1 - 2.3e-30 105.4 14.6 2.8e-30 105.1 14.6 1.1 1 0 0 1 1 1 1 DHHC palmitoyltransferase RRM_1 PF00076.22 AFZ80252.1 - 4.1e-11 42.5 0.0 6e-11 42.0 0.0 1.3 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AFZ80252.1 - 0.17 12.0 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif AMPK1_CBM PF16561.5 AFZ80253.1 - 4.6e-14 52.4 0.0 7.8e-14 51.7 0.0 1.3 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase TB2_DP1_HVA22 PF03134.19 AFZ80254.1 - 5.2e-11 42.3 5.9 5.2e-11 42.3 5.9 1.9 1 1 1 2 2 2 1 TB2/DP1, HVA22 family AWS PF17907.1 AFZ80255.1 - 5.6 7.1 6.1 0.62 10.2 1.2 2.0 2 0 0 2 2 2 0 AWS domain eIF2_C PF09173.11 AFZ80256.1 - 1.1e-34 118.5 0.1 2.9e-34 117.2 0.1 1.8 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 AFZ80256.1 - 9.3e-24 84.0 0.2 1.3e-22 80.4 0.2 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 AFZ80256.1 - 2.5e-11 43.8 3.1 4.8e-11 42.9 0.8 2.5 2 1 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AFZ80256.1 - 0.00037 20.6 0.0 0.00068 19.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AFZ80256.1 - 0.022 14.7 0.9 0.19 11.6 0.2 2.2 2 0 0 2 2 2 0 RsgA GTPase Dak1_2 PF13684.6 AFZ80256.1 - 0.033 13.3 0.2 0.063 12.4 0.2 1.4 1 0 0 1 1 1 0 Dihydroxyacetone kinase family DUF3421 PF11901.8 AFZ80257.1 - 0.00035 20.5 2.6 0.23 11.4 0.2 2.9 1 1 2 3 3 3 2 Protein of unknown function (DUF3421) DUF1416 PF07210.12 AFZ80257.1 - 0.78 9.7 3.8 14 5.7 0.2 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF1416) MafB19-deam PF14437.6 AFZ80257.1 - 3.4 7.4 11.6 4.6 7.0 3.2 2.8 1 1 1 2 2 2 0 MafB19-like deaminase OAD_gamma PF04277.13 AFZ80259.1 - 0.032 14.8 0.2 0.068 13.8 0.0 1.7 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Ribosomal_60s PF00428.19 AFZ80259.1 - 0.076 13.6 0.0 0.094 13.3 0.0 1.1 1 0 0 1 1 1 0 60s Acidic ribosomal protein CAP_N PF01213.19 AFZ80259.1 - 1.1 8.7 7.5 1.3 8.5 7.5 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal TRAPP PF04051.16 AFZ80260.1 - 1.5e-30 105.9 0.1 1.8e-30 105.6 0.1 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Alpha_Helical PF18489.1 AFZ80260.1 - 0.14 12.4 0.0 0.67 10.1 0.0 1.9 1 1 1 2 2 2 0 Alpha helical domain PIN_6 PF17146.4 AFZ80261.1 - 5.1e-21 75.0 0.0 1.3e-20 73.7 0.0 1.7 1 0 0 1 1 1 1 PIN domain of ribonuclease NOB1_Zn_bind PF08772.11 AFZ80261.1 - 2e-20 72.7 1.0 4.3e-20 71.6 1.0 1.6 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like MOLO1 PF17175.4 AFZ80262.1 - 1e-25 90.2 0.0 2.1e-25 89.2 0.0 1.5 1 0 0 1 1 1 1 Modulator of levamisole receptor-1 TPM_phosphatase PF04536.14 AFZ80262.1 - 2.6e-05 24.4 0.0 4.1e-05 23.7 0.0 1.4 1 1 0 1 1 1 1 TPM domain UPF0054 PF02130.17 AFZ80263.1 - 1.7e-22 79.6 1.5 5.2e-21 74.8 1.3 2.5 1 1 1 2 2 2 1 Uncharacterized protein family UPF0054 DUF3591 PF12157.8 AFZ80264.1 - 8e-46 156.6 0.0 1.5e-45 155.7 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3591) Bromodomain PF00439.25 AFZ80264.1 - 2.7e-15 56.2 1.6 5.2e-15 55.3 0.5 2.1 2 0 0 2 2 2 1 Bromodomain zf-CCHC_6 PF15288.6 AFZ80264.1 - 0.004 17.0 1.8 0.004 17.0 1.8 2.1 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.23 AFZ80264.1 - 0.028 14.5 0.5 0.075 13.1 0.5 1.8 1 0 0 1 1 1 0 Zinc knuckle DUF2145 PF09916.9 AFZ80264.1 - 0.1 12.2 0.0 1.1 8.8 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2145) EMP24_GP25L PF01105.24 AFZ80265.1 - 8.4e-25 87.8 0.2 1.1e-24 87.4 0.2 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD CarboxypepD_reg PF13620.6 AFZ80265.1 - 0.041 14.2 0.4 0.066 13.5 0.4 1.4 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain SMODS PF18144.1 AFZ80266.1 - 0.065 13.4 0.1 0.18 11.9 0.1 1.8 1 0 0 1 1 1 0 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain DUF4269 PF14091.6 AFZ80266.1 - 0.07 13.4 0.6 3.9 7.7 0.2 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4269) Tubulin PF00091.25 AFZ80267.1 - 8.1e-64 215.5 0.0 1.2e-63 214.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 AFZ80267.1 - 3.2e-47 159.8 0.3 6e-47 158.9 0.3 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain UcrQ PF02939.16 AFZ80268.1 - 0.05 13.5 0.3 0.091 12.7 0.3 1.4 1 0 0 1 1 1 0 UcrQ family F5_F8_type_C PF00754.25 AFZ80270.1 - 0.07 13.2 1.9 0.24 11.5 0.1 2.7 3 0 0 3 3 3 0 F5/8 type C domain Pdase_C33_assoc PF14756.6 AFZ80270.1 - 0.14 12.1 0.1 0.4 10.6 0.0 1.8 2 0 0 2 2 2 0 Peptidase_C33-associated domain Glutaredoxin PF00462.24 AFZ80272.1 - 5.6e-14 52.1 0.0 5.2e-13 49.0 0.0 2.0 2 0 0 2 2 2 1 Glutaredoxin DUF836 PF05768.14 AFZ80272.1 - 0.017 15.5 0.0 0.021 15.2 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Thioredoxin_9 PF14595.6 AFZ80272.1 - 0.084 12.7 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_2 PF13098.6 AFZ80272.1 - 0.085 13.3 0.3 0.16 12.4 0.3 1.7 1 1 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_3 PF13192.6 AFZ80272.1 - 0.13 12.4 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin domain PDZ_3 PF17815.1 AFZ80273.1 - 8.8e-46 155.4 0.2 1.4e-45 154.7 0.2 1.3 1 0 0 1 1 1 1 PDZ domain Trypsin_2 PF13365.6 AFZ80273.1 - 4.6e-19 69.8 0.1 7.5e-19 69.1 0.1 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 AFZ80273.1 - 1.3e-17 64.3 0.1 2.3e-17 63.5 0.1 1.3 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.6 AFZ80273.1 - 6.2e-09 36.1 1.8 1.9e-05 24.9 0.0 3.1 3 0 0 3 3 3 2 PDZ domain PDZ_6 PF17820.1 AFZ80273.1 - 0.00095 19.0 0.6 0.29 11.0 0.1 2.6 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 AFZ80273.1 - 0.035 14.4 0.2 2.8 8.4 0.0 2.5 2 0 0 2 2 2 0 PDZ domain Ribosomal_L10 PF00466.20 AFZ80274.1 - 3.9e-15 55.8 0.4 8.7e-15 54.7 0.4 1.6 1 0 0 1 1 1 1 Ribosomal protein L10 DUF4097 PF13349.6 AFZ80276.1 - 0.05 12.9 0.1 0.15 11.4 0.1 1.6 1 1 0 1 1 1 0 Putative adhesin Vps36_ESCRT-II PF11605.8 AFZ80276.1 - 0.081 13.1 0.1 0.26 11.5 0.0 1.8 2 0 0 2 2 2 0 Vacuolar protein sorting protein 36 Vps36 UCH PF00443.29 AFZ80277.1 - 1.2e-36 126.6 0.1 1.2e-36 126.6 0.1 2.1 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 AFZ80277.1 - 4.2e-11 43.0 0.0 4.2e-11 43.0 0.0 2.8 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 AFZ80277.1 - 8.2e-11 42.1 0.0 9e-10 38.6 0.0 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.31 AFZ80277.1 - 4.4e-08 32.9 0.0 0.0062 16.4 0.0 2.5 2 0 0 2 2 2 2 UBA/TS-N domain zf-UBP_var PF17807.1 AFZ80277.1 - 2.3e-05 24.0 0.0 6.1e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 Variant UBP zinc finger DUF3173 PF11372.8 AFZ80277.1 - 0.0098 15.7 0.0 0.37 10.7 0.0 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3173) DUF1421 PF07223.11 AFZ80277.1 - 0.033 14.0 0.1 9.2 6.2 0.0 2.9 2 0 0 2 2 2 0 UBA-like domain (DUF1421) Ubiquitin_2 PF14560.6 AFZ80278.1 - 0.0002 21.7 0.2 0.00053 20.4 0.1 1.7 2 0 0 2 2 2 1 Ubiquitin-like domain ubiquitin PF00240.23 AFZ80278.1 - 0.00041 20.0 0.1 0.0016 18.2 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin family RRM_1 PF00076.22 AFZ80279.1 - 1.2e-15 57.1 0.0 2.6e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) eIF3g PF12353.8 AFZ80279.1 - 6.6e-10 39.5 0.9 1.5e-09 38.3 0.9 1.6 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G Fil_haemagg_2 PF13332.6 AFZ80280.1 - 0.085 13.0 1.3 0.12 12.5 0.4 1.7 2 0 0 2 2 2 0 Hemagglutinin repeat FAINT PF04385.15 AFZ80281.1 - 1.5e-12 47.4 0.0 0.0038 17.2 0.1 3.6 3 1 0 3 3 3 3 Domain of unknown function, DUF529 GREB1 PF15782.5 AFZ80281.1 - 7.5 3.5 9.1 12 2.8 9.1 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer ELM2 PF01448.24 AFZ80283.1 - 5.4e-06 27.1 0.1 2.5e-05 24.9 0.1 2.1 1 1 0 1 1 1 1 ELM2 domain DnaJ PF00226.31 AFZ80285.1 - 1.5e-21 76.3 2.4 3.7e-21 75.0 2.4 1.7 1 0 0 1 1 1 1 DnaJ domain T6SS-SciN PF12790.7 AFZ80285.1 - 0.15 11.8 0.0 0.59 9.9 0.0 1.8 2 0 0 2 2 2 0 Type VI secretion lipoprotein, VasD, EvfM, TssJ, VC_A0113 RRM_1 PF00076.22 AFZ80286.1 - 0.00042 20.1 0.0 0.036 13.9 0.0 2.3 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) bPH_5 PF10882.8 AFZ80286.1 - 0.0087 16.1 0.1 0.026 14.6 0.0 1.8 1 1 0 1 1 1 1 Bacterial PH domain DNase_II PF03265.15 AFZ80286.1 - 0.019 14.3 1.8 0.024 13.9 1.8 1.2 1 0 0 1 1 1 0 Deoxyribonuclease II PIN_5 PF08745.11 AFZ80286.1 - 0.12 11.8 0.3 0.18 11.2 0.3 1.2 1 0 0 1 1 1 0 PINc domain ribonuclease ECR1_N PF14382.6 AFZ80287.1 - 2.5e-08 33.6 1.6 5.2e-08 32.6 0.0 2.4 4 0 0 4 4 4 1 Exosome complex exonuclease RRP4 N-terminal region EXOSC1 PF10447.9 AFZ80287.1 - 1.5e-07 32.0 0.5 0.005 17.4 0.0 2.4 1 1 1 2 2 2 2 Exosome component EXOSC1/CSL4 FKBP_N_2 PF18023.1 AFZ80287.1 - 0.17 12.0 0.5 3.9 7.6 0.1 2.1 1 1 1 2 2 2 0 BDBT FKBP like N-terminal Med10 PF09748.9 AFZ80288.1 - 2.7e-05 24.1 0.1 3.8e-05 23.6 0.1 1.1 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex DUF4218 PF13960.6 AFZ80288.1 - 0.03 13.9 0.5 0.07 12.7 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4218) TPK_catalytic PF04263.16 AFZ80288.1 - 0.059 13.4 0.3 0.15 12.1 0.3 1.7 1 1 0 1 1 1 0 Thiamin pyrophosphokinase, catalytic domain DUF3788 PF12663.7 AFZ80289.1 - 0.23 11.4 1.6 6.9 6.7 0.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3788) FAINT PF04385.15 AFZ80290.1 - 3.6e-48 161.5 50.0 4.4e-06 26.7 1.4 12.0 11 1 0 11 11 11 11 Domain of unknown function, DUF529 Viral_P18 PF04521.13 AFZ80290.1 - 0.0034 17.2 0.0 0.0083 15.9 0.0 1.6 1 0 0 1 1 1 1 ssRNA positive strand viral 18kD cysteine rich protein FAINT PF04385.15 AFZ80291.1 - 7.9e-49 163.6 40.0 1.2e-05 25.3 0.0 13.9 13 1 0 13 13 13 11 Domain of unknown function, DUF529 DUF2510 PF10708.9 AFZ80291.1 - 0.045 13.5 0.4 16 5.4 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2510) DUF346 PF03984.13 AFZ80291.1 - 0.094 12.5 0.8 4.5 7.1 0.1 2.7 2 0 0 2 2 2 0 Repeat of unknown function (DUF346) Hydrolase_4 PF12146.8 AFZ80292.1 - 1e-23 83.9 0.0 6e-23 81.4 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FAINT PF04385.15 AFZ80292.1 - 1.9e-13 50.3 11.6 0.0033 17.5 0.0 5.6 5 0 0 5 5 5 4 Domain of unknown function, DUF529 Abhydrolase_6 PF12697.7 AFZ80292.1 - 3.2e-06 27.9 0.0 6.1e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 AFZ80292.1 - 0.00017 21.4 0.1 0.002 17.9 0.1 2.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 AFZ80292.1 - 0.0073 16.4 0.5 0.026 14.6 0.0 2.1 3 0 0 3 3 3 1 TAP-like protein Abhydrolase_2 PF02230.16 AFZ80292.1 - 0.054 13.3 0.1 0.49 10.1 0.0 2.4 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 AFZ80292.1 - 0.073 12.5 0.1 5.1 6.5 0.0 2.6 2 0 0 2 2 2 0 Prolyl oligopeptidase family Rieske_2 PF13806.6 AFZ80293.1 - 1.2e-06 28.4 0.0 1.9e-06 27.7 0.0 1.4 1 1 0 1 1 1 1 Rieske-like [2Fe-2S] domain Rieske PF00355.26 AFZ80293.1 - 5e-06 26.4 0.3 8.2e-06 25.7 0.3 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Pkinase PF00069.25 AFZ80294.1 - 4.6e-44 150.8 0.1 1.1e-43 149.5 0.1 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ80294.1 - 7.3e-23 81.2 0.1 1.4e-22 80.2 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase LAG1-DNAbind PF09271.11 AFZ80294.1 - 0.011 16.4 0.2 0.011 16.4 0.2 2.8 3 1 0 3 3 3 0 LAG1, DNA binding Pox_ser-thr_kin PF05445.11 AFZ80294.1 - 0.044 12.8 0.7 0.073 12.0 0.1 1.6 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase RIO1 PF01163.22 AFZ80294.1 - 0.38 10.3 5.1 1.1 8.8 0.0 3.2 3 0 0 3 3 3 0 RIO1 family NAD_Gly3P_dh_N PF01210.23 AFZ80295.1 - 2.4e-45 154.3 0.3 4.5e-45 153.4 0.3 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 AFZ80295.1 - 2.6e-41 141.2 0.0 6.5e-41 139.9 0.0 1.7 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus IlvN PF07991.12 AFZ80295.1 - 0.013 15.1 0.2 1.3 8.5 0.0 2.5 1 1 1 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain FMO-like PF00743.19 AFZ80295.1 - 0.056 11.9 0.0 0.11 10.8 0.0 1.4 1 1 0 1 1 1 0 Flavin-binding monooxygenase-like NAD_binding_7 PF13241.6 AFZ80295.1 - 0.07 13.6 0.0 0.24 11.9 0.0 1.9 2 0 0 2 2 2 0 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 AFZ80295.1 - 0.13 11.6 0.0 0.57 9.5 0.0 1.8 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain U-box PF04564.15 AFZ80296.1 - 1.9e-22 79.2 0.1 6.3e-22 77.5 0.0 1.9 2 0 0 2 2 2 1 U-box domain TPR_2 PF07719.17 AFZ80296.1 - 9.3e-15 53.5 4.4 2.4e-06 27.2 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 AFZ80296.1 - 9.6e-13 47.6 4.6 6.5e-08 32.1 1.3 2.6 2 0 0 2 2 2 2 TPR repeat TPR_1 PF00515.28 AFZ80296.1 - 1.4e-12 46.9 6.0 3.3e-05 23.5 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat ANAPC3 PF12895.7 AFZ80296.1 - 5.8e-10 39.3 1.7 1e-09 38.5 1.7 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 AFZ80296.1 - 2.8e-09 36.7 2.3 2e-05 24.7 0.3 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 AFZ80296.1 - 1.4e-08 34.3 5.4 6.7e-05 22.8 0.0 3.8 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 AFZ80296.1 - 8.4e-07 29.5 0.0 0.0025 18.4 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 AFZ80296.1 - 2.9e-06 27.6 0.0 0.0083 16.9 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 AFZ80296.1 - 8e-05 22.7 0.0 0.15 12.2 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 AFZ80296.1 - 0.00026 21.2 3.6 0.0053 17.0 1.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 AFZ80296.1 - 0.00026 21.4 0.5 1.2 9.7 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 AFZ80296.1 - 0.00059 19.7 2.0 0.3 11.2 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat zf-NOSIP PF15906.5 AFZ80296.1 - 0.002 18.2 0.0 0.005 17.0 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein TPR_15 PF13429.6 AFZ80296.1 - 0.0077 15.5 0.3 0.011 15.0 0.3 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_MalT PF17874.1 AFZ80296.1 - 0.03 13.7 0.0 5.5 6.3 0.0 2.2 1 1 1 2 2 2 0 MalT-like TPR region TPR_6 PF13174.6 AFZ80296.1 - 0.07 13.8 0.7 48 4.9 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat GTP1_OBG PF01018.22 AFZ80297.1 - 1.5e-47 161.0 5.5 2.4e-47 160.4 5.5 1.3 1 0 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.23 AFZ80297.1 - 1.5e-21 76.6 0.0 3.2e-21 75.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF1967 PF09269.11 AFZ80297.1 - 9.7e-15 54.3 0.0 3.4e-14 52.5 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1967) FeoB_N PF02421.18 AFZ80297.1 - 5.5e-07 29.2 0.0 2.1e-06 27.4 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 AFZ80297.1 - 7.1e-07 29.4 0.4 1.4e-06 28.5 0.0 1.7 2 0 0 2 2 2 1 Dynamin family Gtr1_RagA PF04670.12 AFZ80297.1 - 0.0029 17.0 0.1 0.017 14.5 0.1 2.0 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region KTI12 PF08433.10 AFZ80297.1 - 0.067 12.6 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Arf PF00025.21 AFZ80297.1 - 0.071 12.6 0.0 1.1 8.7 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family MMR_HSR1_Xtn PF16897.5 AFZ80297.1 - 0.097 12.7 0.1 0.3 11.1 0.1 1.8 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain ABC_tran PF00005.27 AFZ80297.1 - 0.1 13.1 0.0 0.24 11.9 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 AFZ80297.1 - 0.11 13.1 0.0 0.31 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 AFZ80297.1 - 0.18 11.7 0.0 2.8 7.8 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase PAXIP1_C PF15364.6 AFZ80300.1 - 0.17 12.2 3.1 0.3 11.4 3.1 1.3 1 0 0 1 1 1 0 PAXIP1-associated-protein-1 C term PTIP binding protein FAINT PF04385.15 AFZ80302.1 - 1.6e-45 153.1 0.1 3.3e-12 46.3 0.0 4.3 4 0 0 4 4 4 4 Domain of unknown function, DUF529 EMA PF02488.15 AFZ80302.1 - 0.00085 19.1 4.9 0.24 11.1 0.1 3.2 3 0 0 3 3 3 2 Merozoite Antigen SPATA3 PF15662.5 AFZ80302.1 - 6.5 7.3 14.9 2.3 8.8 7.4 2.3 2 0 0 2 2 2 0 Spermatogenesis-associated protein 3 family PTS_EIIA_1 PF00358.20 AFZ80303.1 - 0.031 14.0 0.3 0.041 13.6 0.3 1.1 1 0 0 1 1 1 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 SesA PF17107.5 AFZ80304.1 - 0.00038 20.6 1.0 0.00038 20.6 1.0 3.3 3 0 0 3 3 3 1 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF2524 PF10732.9 AFZ80304.1 - 0.0019 18.5 2.6 0.0019 18.5 2.6 3.5 3 0 0 3 3 3 1 Protein of unknown function (DUF2524) APG6_N PF17675.1 AFZ80304.1 - 0.0041 17.7 15.0 0.0041 17.7 15.0 3.1 2 0 0 2 2 2 1 Apg6 coiled-coil region DUF3797 PF12677.7 AFZ80304.1 - 0.053 13.4 1.6 12 5.9 0.2 3.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) DUF4715 PF15835.5 AFZ80304.1 - 0.35 10.9 3.6 0.16 12.0 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4715) Lebercilin PF15619.6 AFZ80304.1 - 3.3 7.3 39.4 0.42 10.2 3.5 4.6 4 1 0 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease Fez1 PF06818.15 AFZ80304.1 - 5.6 7.4 25.0 4 7.9 4.0 2.9 2 0 0 2 2 2 0 Fez1 HALZ PF02183.18 AFZ80305.1 - 0.0002 21.5 9.9 0.064 13.5 0.1 3.2 2 1 1 3 3 3 2 Homeobox associated leucine zipper TMF_TATA_bd PF12325.8 AFZ80305.1 - 0.00057 20.1 2.0 0.026 14.7 1.1 2.1 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding DUF3584 PF12128.8 AFZ80305.1 - 0.0028 15.3 0.1 0.0034 15.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Phage_GP20 PF06810.11 AFZ80305.1 - 0.005 16.6 2.6 0.035 13.9 2.6 2.0 1 1 0 1 1 1 1 Phage minor structural protein GP20 DivIC PF04977.15 AFZ80305.1 - 0.011 15.4 1.6 0.24 11.2 1.1 2.6 2 1 1 3 3 3 0 Septum formation initiator DUF465 PF04325.13 AFZ80305.1 - 0.016 15.2 0.3 4 7.6 0.0 3.0 2 1 0 3 3 3 0 Protein of unknown function (DUF465) YabA PF06156.13 AFZ80305.1 - 0.017 15.8 0.4 0.22 12.2 0.2 2.1 1 1 1 2 2 2 0 Initiation control protein YabA HalX PF08663.10 AFZ80305.1 - 0.021 15.1 3.6 1.4 9.3 2.0 2.7 2 1 0 2 2 2 0 HalX domain ABC_tran_CTD PF16326.5 AFZ80305.1 - 0.026 14.8 0.7 5.9 7.2 0.0 2.4 2 0 0 2 2 2 0 ABC transporter C-terminal domain DUF3958 PF13125.6 AFZ80305.1 - 0.026 14.7 0.2 0.13 12.4 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3958) KASH_CCD PF14662.6 AFZ80305.1 - 0.029 14.2 2.0 0.45 10.3 0.4 2.1 1 1 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH ZapB PF06005.12 AFZ80305.1 - 0.033 14.6 2.0 0.47 10.9 2.0 2.6 1 1 0 1 1 1 0 Cell division protein ZapB bZIP_1 PF00170.21 AFZ80305.1 - 0.04 14.0 4.0 0.51 10.5 0.3 3.0 2 2 0 2 2 2 0 bZIP transcription factor GldM_N PF12081.8 AFZ80305.1 - 0.04 14.0 1.7 0.063 13.4 1.7 1.3 1 1 0 1 1 1 0 GldM N-terminal domain Spectrin PF00435.21 AFZ80305.1 - 0.041 14.4 1.4 0.16 12.5 0.5 2.1 2 0 0 2 2 2 0 Spectrin repeat UPF0242 PF06785.11 AFZ80305.1 - 0.041 14.0 2.2 0.097 12.8 2.4 1.6 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Occludin_ELL PF07303.13 AFZ80305.1 - 0.044 14.5 1.4 0.21 12.4 1.4 2.1 1 1 1 2 2 2 0 Occludin homology domain LPD39 PF18858.1 AFZ80305.1 - 0.052 13.6 3.2 2.9 7.9 0.3 2.3 1 1 1 2 2 2 0 Large polyvalent protein associated domain 39 Nnf1 PF03980.14 AFZ80305.1 - 0.082 13.3 0.4 7.6 7.0 0.4 2.4 2 1 0 2 2 2 0 Nnf1 LPP PF04728.13 AFZ80305.1 - 0.086 13.2 0.1 19 5.7 0.0 2.7 2 1 1 3 3 3 0 Lipoprotein leucine-zipper CENP-F_leu_zip PF10473.9 AFZ80305.1 - 0.097 12.7 2.3 0.79 9.7 2.5 2.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 EzrA PF06160.12 AFZ80305.1 - 0.11 10.6 3.2 0.14 10.3 3.2 1.2 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Tup_N PF08581.10 AFZ80305.1 - 0.11 12.8 3.0 6.7 7.1 0.3 3.1 2 2 1 3 3 3 0 Tup N-terminal Bap31_Bap29_C PF18035.1 AFZ80305.1 - 0.12 12.4 6.3 4.8 7.3 4.3 3.3 2 1 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Fungal_TACC PF12709.7 AFZ80305.1 - 0.13 12.7 4.9 4.9 7.7 2.4 2.8 1 1 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins GrpE PF01025.19 AFZ80305.1 - 0.14 11.8 2.8 2.7 7.6 2.1 2.2 2 1 0 2 2 2 0 GrpE HMMR_C PF15908.5 AFZ80305.1 - 0.15 12.3 1.6 0.22 11.8 0.7 1.7 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor C-terminal Cep57_CLD_2 PF14197.6 AFZ80305.1 - 0.19 11.9 2.1 1.2 9.2 0.7 2.1 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 RL10P_insert PF17777.1 AFZ80306.1 - 4.8e-21 74.5 0.2 1e-20 73.5 0.2 1.6 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 AFZ80306.1 - 3.8e-19 68.7 0.7 7.2e-19 67.8 0.2 1.7 2 0 0 2 2 2 1 Ribosomal protein L10 Ribosomal_60s PF00428.19 AFZ80306.1 - 2.4e-18 66.5 8.5 4.7e-18 65.6 8.5 1.5 1 0 0 1 1 1 1 60s Acidic ribosomal protein Ribosomal_L38e PF01781.18 AFZ80307.1 - 8.7e-26 89.8 0.9 9.7e-26 89.7 0.9 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family HAGH_C PF16123.5 AFZ80308.1 - 5e-23 81.4 0.1 7.9e-23 80.8 0.1 1.3 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 AFZ80308.1 - 1.3e-07 31.8 0.0 0.0069 16.4 0.0 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 AFZ80308.1 - 0.044 13.3 0.0 0.073 12.6 0.0 1.5 1 1 0 1 1 1 0 Beta-lactamase superfamily domain FAM198 PF15051.6 AFZ80308.1 - 0.13 11.1 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 FAM198 protein DUF2981 PF11200.8 AFZ80309.1 - 8.6e-75 252.5 0.2 1.8e-74 251.5 0.2 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF2981) AAA PF00004.29 AFZ80310.1 - 5.1e-41 140.2 0.1 1.2e-40 139.0 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 AFZ80310.1 - 7.7e-20 70.6 1.2 1.3e-19 69.9 0.2 1.9 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 AFZ80310.1 - 3.7e-13 49.1 0.2 8.1e-13 48.0 0.2 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 AFZ80310.1 - 2.5e-06 27.6 0.1 1.3e-05 25.2 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 AFZ80310.1 - 2.2e-05 24.9 0.2 0.0043 17.4 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 AFZ80310.1 - 2.5e-05 24.5 0.0 0.00012 22.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 AFZ80310.1 - 6.6e-05 22.7 0.0 0.00015 21.5 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 AFZ80310.1 - 0.00074 19.7 0.0 0.0015 18.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 AFZ80310.1 - 0.0017 17.8 0.2 0.02 14.3 0.1 2.6 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 AFZ80310.1 - 0.0025 18.1 5.3 0.032 14.5 0.1 3.1 2 2 0 3 3 3 1 AAA domain PhoH PF02562.16 AFZ80310.1 - 0.022 14.2 0.0 0.057 12.9 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein PyrI PF01948.18 AFZ80310.1 - 0.028 14.6 0.2 0.088 13.1 0.1 2.0 2 0 0 2 2 1 0 Aspartate carbamoyltransferase regulatory chain, allosteric domain IstB_IS21 PF01695.17 AFZ80310.1 - 0.028 14.1 0.0 0.06 13.1 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_14 PF13173.6 AFZ80310.1 - 0.036 14.1 0.0 0.11 12.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 AFZ80310.1 - 0.061 13.0 0.1 0.4 10.4 0.0 2.3 2 1 0 2 2 2 0 Sigma-54 interaction domain CPT PF07931.12 AFZ80310.1 - 0.089 12.6 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_19 PF13245.6 AFZ80310.1 - 0.09 13.1 0.0 0.22 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 AFZ80310.1 - 0.094 12.2 0.5 0.72 9.3 0.1 2.4 2 1 0 2 2 2 0 P-loop containing dynein motor region AAA_3 PF07726.11 AFZ80310.1 - 0.12 12.2 0.1 0.41 10.5 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 AFZ80310.1 - 0.16 11.7 0.1 0.16 11.7 0.1 2.2 2 1 0 2 2 2 0 AAA domain ATPase PF06745.13 AFZ80310.1 - 0.24 10.7 2.7 0.24 10.7 0.0 2.3 3 0 0 3 3 3 0 KaiC DUF2205 PF10224.9 AFZ80310.1 - 0.46 10.5 3.6 0.32 11.0 1.2 2.0 2 0 0 2 2 1 0 Short coiled-coil protein DUF3510 PF12022.8 AFZ80311.1 - 2.1e-15 57.2 4.7 3.5e-15 56.5 1.7 3.1 3 1 0 3 3 3 1 Domain of unknown function (DUF3510) Abi_C PF14355.6 AFZ80311.1 - 0.017 15.2 0.2 0.085 13.0 0.0 2.3 3 0 0 3 3 3 0 Abortive infection C-terminus Med4 PF10018.9 AFZ80311.1 - 0.024 14.3 0.9 0.056 13.1 0.0 2.0 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Ufm1 PF03671.14 AFZ80312.1 - 4e-39 132.6 0.1 4.5e-39 132.4 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin fold modifier 1 protein SMC_N PF02463.19 AFZ80313.1 - 1.6e-46 158.6 13.0 7.5e-46 156.3 13.0 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 AFZ80313.1 - 5.9e-25 87.8 0.0 2.4e-24 85.9 0.0 2.2 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 AFZ80313.1 - 7.4e-13 49.0 4.2 2.3e-07 30.9 0.1 3.2 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 AFZ80313.1 - 9.2e-10 39.3 23.8 9.2e-10 39.3 23.8 6.5 2 2 1 3 3 2 1 AAA domain AAA_15 PF13175.6 AFZ80313.1 - 1e-08 35.3 26.4 1e-08 35.3 26.4 4.1 2 2 2 4 4 2 1 AAA ATPase domain AAA_29 PF13555.6 AFZ80313.1 - 1.2e-08 34.6 0.0 5.6e-08 32.4 0.0 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 AFZ80313.1 - 0.019 15.3 1.0 7.6 6.8 0.0 3.4 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 AFZ80313.1 - 0.02 15.3 0.0 4.6 7.7 0.0 3.5 2 0 0 2 2 2 0 RNA helicase ABC_tran PF00005.27 AFZ80313.1 - 0.026 15.1 0.0 0.026 15.1 0.0 5.9 4 3 0 4 4 2 0 ABC transporter DUF4407 PF14362.6 AFZ80313.1 - 0.26 10.6 50.5 0.0092 15.4 8.4 4.5 2 2 2 4 4 4 0 Domain of unknown function (DUF4407) MukB PF04310.12 AFZ80313.1 - 0.44 10.3 0.0 0.44 10.3 0.0 4.4 4 1 0 4 4 4 0 MukB N-terminal Spc7 PF08317.11 AFZ80313.1 - 1.3 7.9 101.2 0.0067 15.4 6.1 7.7 3 2 5 8 8 8 0 Spc7 kinetochore protein RRM_1 PF00076.22 AFZ80314.1 - 2.2e-19 69.1 0.0 5.8e-09 35.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PARG_cat PF05028.14 AFZ80314.1 - 0.12 11.6 0.1 0.16 11.2 0.1 1.1 1 0 0 1 1 1 0 Poly (ADP-ribose) glycohydrolase (PARG) WD40 PF00400.32 AFZ80315.1 - 0.01 16.7 5.5 0.41 11.6 0.1 4.2 4 0 0 4 4 4 0 WD domain, G-beta repeat HEAT PF02985.22 AFZ80316.1 - 2.3e-13 49.2 3.7 0.0084 16.3 0.0 8.7 9 0 0 9 9 8 3 HEAT repeat Importin_rep_4 PF18808.1 AFZ80316.1 - 4.5e-12 46.1 0.0 7.1e-11 42.2 0.0 2.9 2 0 0 2 2 2 1 Importin repeat Vac14_Fab1_bd PF12755.7 AFZ80316.1 - 3.8e-11 43.4 4.4 0.0083 16.7 0.1 6.0 3 1 3 6 6 6 2 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.6 AFZ80316.1 - 1.6e-09 38.0 1.7 0.0039 17.5 0.0 6.6 5 2 4 9 9 8 3 HEAT repeats HEAT_EZ PF13513.6 AFZ80316.1 - 4.9e-09 36.5 0.1 0.00069 20.1 0.0 6.4 3 1 2 5 5 5 2 HEAT-like repeat Cnd1 PF12717.7 AFZ80316.1 - 2.9e-06 27.4 3.2 0.0055 16.8 0.1 5.1 4 2 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.8 AFZ80316.1 - 3.6e-06 27.0 4.7 0.038 13.9 0.7 5.0 6 1 0 6 6 5 2 Domain of unknown function (DUF3385) IFRD PF05004.13 AFZ80316.1 - 0.00011 21.4 6.2 0.073 12.2 0.1 4.6 4 1 1 5 5 5 2 Interferon-related developmental regulator (IFRD) RIX1 PF08167.12 AFZ80316.1 - 0.0014 18.4 1.5 2.6 7.7 0.0 5.6 4 2 3 7 7 7 1 rRNA processing/ribosome biogenesis RTP1_C1 PF10363.9 AFZ80316.1 - 0.0015 18.7 4.8 0.0073 16.5 0.1 4.5 4 1 1 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 UME PF08064.13 AFZ80316.1 - 0.002 18.0 3.9 5.5 7.0 0.1 6.4 4 1 2 6 6 6 1 UME (NUC010) domain DUF4413 PF14372.6 AFZ80316.1 - 0.0086 16.4 0.7 0.93 9.9 0.0 3.7 4 0 0 4 4 4 1 Domain of unknown function (DUF4413) Arm PF00514.23 AFZ80316.1 - 0.016 15.2 3.7 15 5.8 0.0 5.6 7 0 0 7 7 5 0 Armadillo/beta-catenin-like repeat Proteasom_PSMB PF10508.9 AFZ80316.1 - 0.025 13.1 0.7 1.2 7.5 0.1 3.4 2 1 1 3 3 3 0 Proteasome non-ATPase 26S subunit IBN_N PF03810.19 AFZ80316.1 - 0.047 13.6 0.5 0.44 10.5 0.2 3.0 2 0 0 2 2 2 0 Importin-beta N-terminal domain MMS19_N PF14500.6 AFZ80316.1 - 0.46 10.0 5.0 6.9 6.2 0.0 5.1 7 1 0 8 8 8 0 Dos2-interacting transcription regulator of RNA-Pol-II DUF4698 PF15769.5 AFZ80317.1 - 0.15 11.1 0.0 0.19 10.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) WASH_WAHD PF11945.8 AFZ80317.1 - 0.2 11.1 2.4 0.49 9.9 1.3 1.8 1 1 1 2 2 2 0 WAHD domain of WASH complex Hydrolase_3 PF08282.12 AFZ80318.1 - 2e-35 122.8 0.0 2.8e-35 122.3 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 AFZ80318.1 - 4.6e-05 23.1 0.0 0.025 14.1 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Acid_phosphat_B PF03767.14 AFZ80318.1 - 0.2 11.2 0.0 0.72 9.4 0.0 1.8 2 0 0 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) ApoC-I PF04691.12 AFZ80319.1 - 0.66 10.0 3.9 0.55 10.2 1.4 2.0 2 0 0 2 2 2 0 Apolipoprotein C-I (ApoC-1) FAINT PF04385.15 AFZ80320.1 - 7.6e-32 109.2 0.5 5.5e-05 23.1 0.0 6.7 6 0 0 6 6 6 6 Domain of unknown function, DUF529 Tox-SHH PF15652.6 AFZ80320.1 - 0.0014 19.6 1.2 2.6 9.1 0.0 4.3 5 0 0 5 5 5 1 HNH/Endo VII superfamily toxin with a SHH signature Myco_19_kDa PF05481.12 AFZ80320.1 - 0.0017 18.7 2.6 2.6 8.3 0.0 4.1 3 1 0 3 3 3 2 Mycobacterium 19 kDa lipoprotein antigen TA_inhibitor PF17574.2 AFZ80320.1 - 0.016 15.3 0.5 0.054 13.5 0.2 2.0 2 0 0 2 2 2 0 Inhibitor of toxin/antitoxin system (Gp4.5) GSH_synth_ATP PF03917.17 AFZ80321.1 - 6.3e-52 176.6 0.0 5e-51 173.6 0.0 1.9 1 1 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 AFZ80321.1 - 2.3e-18 66.5 0.1 6.3e-18 65.1 0.1 1.8 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Gal_Lectin PF02140.18 AFZ80322.1 - 9.9e-05 22.7 8.5 1.5 9.3 0.4 4.5 4 0 0 4 4 4 3 Galactose binding lectin domain Prefoldin_2 PF01920.20 AFZ80323.1 - 1e-16 60.8 10.0 1.3e-16 60.5 10.0 1.1 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_3 PF13758.6 AFZ80323.1 - 0.00026 21.0 2.7 0.0008 19.4 2.4 2.1 1 1 0 1 1 1 1 Prefoldin subunit Fib_alpha PF08702.10 AFZ80323.1 - 0.011 15.9 9.3 0.02 15.1 9.3 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Prefoldin PF02996.17 AFZ80323.1 - 0.031 14.2 3.3 0.031 14.2 3.3 2.3 1 1 1 2 2 2 0 Prefoldin subunit End3 PF12761.7 AFZ80323.1 - 0.045 13.9 5.5 0.089 13.0 5.5 1.5 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 DUF948 PF06103.11 AFZ80323.1 - 0.088 13.1 0.2 0.088 13.1 0.2 1.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) PLAC9 PF15205.6 AFZ80323.1 - 0.14 12.5 0.0 0.23 11.9 0.0 1.3 1 0 0 1 1 1 0 Placenta-specific protein 9 COG2 PF06148.11 AFZ80323.1 - 0.3 11.2 5.8 0.089 12.9 1.1 1.9 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 YjcZ PF13990.6 AFZ80323.1 - 0.36 10.2 3.5 0.42 9.9 3.5 1.1 1 0 0 1 1 1 0 YjcZ-like protein Atg14 PF10186.9 AFZ80323.1 - 0.4 9.7 11.9 0.58 9.2 11.9 1.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1664 PF07889.12 AFZ80323.1 - 0.43 10.6 4.2 0.15 12.1 0.5 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 AFZ80323.1 - 0.73 10.3 6.3 0.25 11.8 2.7 2.2 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DivIC PF04977.15 AFZ80323.1 - 1.9 8.3 10.3 1.1 9.1 0.5 2.4 1 1 1 2 2 2 0 Septum formation initiator XhlA PF10779.9 AFZ80323.1 - 3.8 7.8 9.6 0.29 11.4 3.7 1.9 2 0 0 2 2 2 0 Haemolysin XhlA Spc24 PF08286.11 AFZ80323.1 - 7.5 6.8 11.8 0.47 10.7 2.9 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Dus PF01207.17 AFZ80325.1 - 1e-69 235.0 0.0 1.5e-69 234.5 0.0 1.2 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 AFZ80325.1 - 0.074 12.5 0.0 0.26 10.7 0.0 1.7 2 0 0 2 2 2 0 Histidine biosynthesis protein LexA_DNA_bind PF01726.16 AFZ80326.1 - 0.12 12.2 0.0 0.21 11.4 0.0 1.5 1 1 0 1 1 1 0 LexA DNA binding domain Ndr PF03096.14 AFZ80326.1 - 0.19 10.4 0.0 0.23 10.1 0.0 1.1 1 0 0 1 1 1 0 Ndr family AvrRpt-cleavage PF05627.11 AFZ80326.1 - 0.19 11.1 0.4 0.46 9.9 0.1 1.8 1 1 1 2 2 2 0 Cleavage site for pathogenic type III effector avirulence factor Avr FAST_1 PF06743.15 AFZ80327.1 - 2.1 8.3 12.4 0.81 9.7 0.1 3.6 4 0 0 4 4 4 0 FAST kinase-like protein, subdomain 1 GSH_synth_ATP PF03917.17 AFZ80328.1 - 6.4e-52 176.6 0.0 5.7e-51 173.5 0.0 1.9 1 1 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 AFZ80328.1 - 4e-15 56.1 0.0 1e-14 54.8 0.0 1.8 1 0 0 1 1 1 1 Eukaryotic glutathione synthase CGI-121 PF08617.10 AFZ80329.1 - 3.6e-14 53.2 0.1 4.7e-14 52.8 0.1 1.1 1 0 0 1 1 1 1 Kinase binding protein CGI-121 MORN PF02493.20 AFZ80330.1 - 3.6e-32 108.3 42.5 2.5e-05 23.9 0.4 13.0 13 0 0 13 13 13 9 MORN repeat Avl9 PF09794.9 AFZ80330.1 - 2.5e-26 92.3 0.1 4.9e-24 84.7 0.1 2.2 1 1 0 1 1 1 1 Transport protein Avl9 DENN PF02141.21 AFZ80330.1 - 7.7e-05 22.7 0.2 0.55 10.2 0.0 2.6 2 0 0 2 2 2 2 DENN (AEX-3) domain XisI PF08869.11 AFZ80330.1 - 0.096 13.0 0.1 0.21 12.0 0.1 1.5 1 0 0 1 1 1 0 XisI protein TCTP PF00838.17 AFZ80331.1 - 1.3e-52 178.5 0.2 1.5e-52 178.3 0.2 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein Big_3 PF07523.12 AFZ80331.1 - 0.013 15.8 0.1 0.036 14.4 0.1 1.7 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 3) zf-MYND PF01753.18 AFZ80332.1 - 5.5e-11 42.4 13.2 1.1e-10 41.4 13.2 1.5 1 0 0 1 1 1 1 MYND finger HARP PF07443.13 AFZ80332.1 - 0.093 12.4 0.0 0.23 11.1 0.0 1.6 1 0 0 1 1 1 0 HepA-related protein (HARP) zf-C6H2 PF15801.5 AFZ80332.1 - 4.2 7.8 11.1 11 6.5 11.1 1.7 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding GTP_EFTU PF00009.27 AFZ80333.1 - 4e-60 202.7 0.0 6e-60 202.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 AFZ80333.1 - 2.4e-38 130.6 0.1 4.3e-38 129.8 0.1 1.4 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 AFZ80333.1 - 7.2e-29 99.7 0.1 1.5e-28 98.7 0.1 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 AFZ80333.1 - 1.1e-26 92.7 0.0 4e-26 90.9 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 AFZ80333.1 - 1.3e-14 54.3 0.0 2.8e-14 53.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 AFZ80333.1 - 0.036 13.9 0.0 0.08 12.8 0.0 1.5 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain MMR_HSR1_Xtn PF16897.5 AFZ80334.1 - 7.8e-42 141.6 0.5 1.3e-41 140.9 0.5 1.3 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 AFZ80334.1 - 3.6e-22 78.6 0.0 7.1e-22 77.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 AFZ80334.1 - 1.4e-20 73.1 0.0 2.4e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 AFZ80334.1 - 1.1e-11 44.5 0.1 3.2e-11 43.0 0.0 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 AFZ80334.1 - 5.4e-06 26.6 0.3 0.048 13.7 0.0 2.3 1 1 1 2 2 2 2 Dynamin family MeaB PF03308.16 AFZ80334.1 - 0.00085 18.4 0.3 0.0021 17.1 0.1 1.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AIG1 PF04548.16 AFZ80334.1 - 0.0039 16.5 0.1 0.0056 16.0 0.1 1.3 1 0 0 1 1 1 1 AIG1 family SRPRB PF09439.10 AFZ80334.1 - 0.05 13.0 0.0 0.089 12.2 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 AFZ80334.1 - 0.11 12.0 0.5 54 3.2 0.0 3.5 2 2 2 4 4 4 0 Elongation factor Tu GTP binding domain TAFII55_N PF04658.13 AFZ80334.1 - 0.15 11.8 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 TAFII55 protein conserved region Roc PF08477.13 AFZ80334.1 - 0.16 12.2 0.3 1.8 8.8 0.0 2.5 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase TFIID_30kDa PF03540.13 AFZ80335.1 - 0.012 15.6 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID 23-30kDa subunit WPP PF13943.6 AFZ80335.1 - 0.15 12.4 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 WPP domain SET PF00856.28 AFZ80336.1 - 9.3e-12 45.6 0.2 8.7e-11 42.5 0.0 2.8 2 1 0 2 2 2 1 SET domain LEM PF03020.15 AFZ80338.1 - 0.24 11.0 0.9 0.62 9.7 0.9 1.7 1 0 0 1 1 1 0 LEM domain Adeno_E3_CR1 PF02440.15 AFZ80338.1 - 0.25 11.1 4.8 0.66 9.8 0.5 3.2 2 1 1 3 3 3 0 Adenovirus E3 region protein CR1 Ribosomal_L29 PF00831.23 AFZ80338.1 - 0.41 10.7 2.1 10 6.1 1.7 2.4 2 0 0 2 2 2 0 Ribosomal L29 protein Lipoprotein_22 PF17294.2 AFZ80340.1 - 0.011 15.3 0.7 0.017 14.8 0.7 1.3 1 0 0 1 1 1 0 Uncharacterised lipoprotein family DUF4362 PF14275.6 AFZ80340.1 - 0.024 14.9 1.2 0.037 14.3 0.0 1.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4362) FAINT PF04385.15 AFZ80340.1 - 0.024 14.7 1.0 0.024 14.7 1.0 2.3 2 1 1 3 3 3 0 Domain of unknown function, DUF529 ABC_tran PF00005.27 AFZ80341.1 - 1.3e-31 109.9 0.0 2.9e-17 63.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 AFZ80341.1 - 3e-06 27.1 20.4 3e-06 27.1 20.4 2.3 3 0 0 3 3 1 1 ABC transporter transmembrane region AAA_29 PF13555.6 AFZ80341.1 - 3e-05 23.7 1.1 0.076 12.8 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 AFZ80341.1 - 4.4e-05 23.9 0.0 0.041 14.3 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 AFZ80341.1 - 5.1e-05 23.9 4.6 0.31 11.5 0.7 3.1 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.6 AFZ80341.1 - 5.6e-05 22.9 0.0 0.11 12.2 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 AFZ80341.1 - 0.00012 22.0 7.3 0.1 12.4 0.0 3.9 4 1 0 4 4 3 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 AFZ80341.1 - 0.00031 20.7 0.1 0.056 13.4 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase DnaB_C PF03796.15 AFZ80341.1 - 0.00038 19.9 0.0 0.058 12.7 0.0 2.4 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_18 PF13238.6 AFZ80341.1 - 0.00065 20.3 0.1 1.1 9.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 AFZ80341.1 - 0.0015 17.8 0.3 0.52 9.6 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin DUF87 PF01935.17 AFZ80341.1 - 0.0019 18.3 2.5 0.062 13.4 0.1 2.9 3 0 0 3 3 3 1 Helicase HerA, central domain AAA_22 PF13401.6 AFZ80341.1 - 0.0054 17.0 0.0 0.75 10.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 AFZ80341.1 - 0.0075 15.7 0.4 0.2 11.1 0.1 2.6 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 AFZ80341.1 - 0.0082 15.9 1.0 3.4 7.3 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 AFZ80341.1 - 0.0091 16.1 0.3 0.14 12.2 0.1 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase NACHT PF05729.12 AFZ80341.1 - 0.012 15.5 0.5 3 7.8 0.1 2.5 2 0 0 2 2 2 0 NACHT domain FtsK_SpoIIIE PF01580.18 AFZ80341.1 - 0.012 14.9 0.3 1.8 7.8 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family cobW PF02492.19 AFZ80341.1 - 0.02 14.5 0.3 6.7 6.3 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.20 AFZ80341.1 - 0.034 13.2 0.5 5.6 5.9 0.1 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein MeaB PF03308.16 AFZ80341.1 - 0.043 12.8 0.4 0.11 11.5 0.0 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB SbcCD_C PF13558.6 AFZ80341.1 - 0.049 13.9 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit NB-ARC PF00931.22 AFZ80341.1 - 0.056 12.6 0.3 1.4 8.1 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain ATP_bind_1 PF03029.17 AFZ80341.1 - 0.08 12.7 0.1 12 5.6 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_25 PF13481.6 AFZ80341.1 - 0.08 12.5 0.1 2 7.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 AFZ80341.1 - 0.091 11.7 0.2 4.1 6.2 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain NTPase_1 PF03266.15 AFZ80341.1 - 0.11 12.4 0.3 8.1 6.3 0.1 2.3 2 0 0 2 2 2 0 NTPase TsaE PF02367.17 AFZ80341.1 - 0.11 12.4 0.2 3.2 7.8 0.1 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Dynamin_N PF00350.23 AFZ80341.1 - 0.18 11.9 0.8 8 6.5 0.0 2.5 2 0 0 2 2 2 0 Dynamin family DUF1580 PF07618.11 AFZ80342.1 - 0.04 13.5 0.0 0.096 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1580) 2-oxoacid_dh PF00198.23 AFZ80343.1 - 3.3e-79 265.6 0.1 4.5e-79 265.2 0.1 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 AFZ80343.1 - 2.7e-16 59.2 0.3 5.1e-16 58.3 0.3 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme Mito_fiss_reg PF05308.11 AFZ80343.1 - 2 8.4 6.8 3.1 7.8 6.8 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator zf-C3H2C3 PF17122.5 AFZ80345.1 - 0.0026 17.8 1.9 0.0026 17.8 1.9 2.8 3 0 0 3 3 3 1 Zinc-finger zf-RING_11 PF17123.5 AFZ80345.1 - 0.28 10.9 2.4 0.39 10.5 0.4 2.4 2 0 0 2 2 2 0 RING-like zinc finger Clathrin PF00637.20 AFZ80345.1 - 0.32 10.9 17.5 0.038 13.9 1.8 4.1 4 0 0 4 4 4 0 Region in Clathrin and VPS zf-C3HC4_2 PF13923.6 AFZ80345.1 - 0.39 10.6 9.5 0.45 10.4 5.6 2.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AFZ80345.1 - 0.91 9.9 8.0 1.3 9.5 2.8 3.2 2 0 0 2 2 2 0 Ring finger domain Fz PF01392.22 AFZ80348.1 - 0.013 16.1 0.4 0.013 16.1 0.4 2.4 2 0 0 2 2 2 0 Fz domain ABC_membrane PF00664.23 AFZ80350.1 - 2.2e-35 122.7 1.3 3.1e-35 122.1 1.3 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 AFZ80350.1 - 4.9e-35 121.0 0.0 1.3e-34 119.6 0.0 1.8 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 AFZ80350.1 - 2.9e-07 30.1 0.2 4.9e-05 22.9 0.1 2.3 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 AFZ80350.1 - 6.7e-07 29.4 0.1 0.011 15.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 AFZ80350.1 - 0.00046 20.5 0.3 0.0061 16.8 0.3 2.5 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 AFZ80350.1 - 0.0011 18.9 0.0 0.0065 16.4 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 AFZ80350.1 - 0.0056 16.4 0.1 0.013 15.3 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_33 PF13671.6 AFZ80350.1 - 0.013 15.7 0.2 0.032 14.4 0.2 1.8 1 1 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 AFZ80350.1 - 0.017 14.8 0.0 0.034 13.9 0.0 1.5 1 0 0 1 1 1 0 Cytidylate kinase AAA_16 PF13191.6 AFZ80350.1 - 0.022 15.1 0.1 0.065 13.6 0.1 1.9 1 1 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.12 AFZ80350.1 - 0.025 13.9 0.0 0.083 12.2 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin ABC_ATPase PF09818.9 AFZ80350.1 - 0.03 13.1 0.3 0.21 10.3 0.0 2.1 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_23 PF13476.6 AFZ80350.1 - 0.037 14.5 0.1 0.037 14.5 0.1 1.7 2 0 0 2 2 1 0 AAA domain DUF87 PF01935.17 AFZ80350.1 - 0.04 14.0 0.1 0.13 12.4 0.1 1.8 1 0 0 1 1 1 0 Helicase HerA, central domain Mg_chelatase PF01078.21 AFZ80350.1 - 0.043 13.2 0.0 0.076 12.4 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 AFZ80350.1 - 0.043 14.2 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 AFZ80350.1 - 0.054 14.0 0.0 0.13 12.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 AFZ80350.1 - 0.073 13.2 0.0 0.2 11.7 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_14 PF13173.6 AFZ80350.1 - 0.091 12.8 0.0 0.28 11.2 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 AFZ80350.1 - 0.11 12.2 0.0 0.3 10.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 AFZ80350.1 - 0.13 11.8 0.0 0.65 9.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 AFZ80350.1 - 0.15 11.8 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_13 PF13166.6 AFZ80350.1 - 0.16 10.6 0.0 2.5 6.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 AFZ80350.1 - 0.27 11.5 0.4 0.76 10.0 0.3 1.8 2 0 0 2 2 2 0 AAA domain Rgp1 PF08737.10 AFZ80351.1 - 5.2e-06 25.9 2.8 0.0003 20.1 0.9 2.2 2 0 0 2 2 2 2 Rgp1 Arrestin_N PF00339.29 AFZ80351.1 - 0.00025 21.1 1.2 0.00079 19.5 0.1 2.3 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Laminin_G_3 PF13385.6 AFZ80352.1 - 7.7e-24 84.6 0.1 1.9e-23 83.3 0.0 1.7 1 1 1 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 AFZ80352.1 - 0.0012 19.4 0.1 0.0037 17.8 0.0 1.8 2 0 0 2 2 2 1 Laminin G domain Sialidase PF02973.16 AFZ80352.1 - 0.046 13.2 0.0 0.12 11.9 0.0 1.6 1 1 0 1 1 1 0 Sialidase, N-terminal domain Thg1 PF04446.12 AFZ80354.1 - 7.4e-48 161.7 0.1 1.1e-47 161.1 0.1 1.3 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.6 AFZ80354.1 - 2.4e-35 121.3 0.6 5.5e-35 120.2 0.6 1.6 1 1 0 1 1 1 1 Thg1 C terminal domain MBOAT PF03062.19 AFZ80355.1 - 2.3e-18 66.7 27.6 4e-18 65.9 27.6 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family HALZ PF02183.18 AFZ80355.1 - 9.7e-06 25.7 22.6 0.019 15.2 2.5 5.2 4 0 0 4 4 4 2 Homeobox associated leucine zipper MBOAT_2 PF13813.6 AFZ80355.1 - 0.06 13.6 4.4 0.18 12.1 4.4 1.8 1 0 0 1 1 1 0 Membrane bound O-acyl transferase family HCMV_UL139 PF12507.8 AFZ80355.1 - 0.15 12.4 8.2 5 7.5 3.3 3.3 1 1 1 2 2 2 0 Human Cytomegalovirus UL139 protein DUF2935 PF11155.8 AFZ80355.1 - 1.5 9.2 8.3 2.3 8.6 1.6 4.0 2 1 1 3 3 3 0 Domain of unknown function (DUF2935) CENP-F_leu_zip PF10473.9 AFZ80355.1 - 1.9 8.5 64.9 0.081 12.9 7.4 5.1 2 1 3 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 mRNA_triPase PF02940.15 AFZ80356.1 - 3.7e-41 141.3 0.1 7.9e-41 140.2 0.1 1.5 2 0 0 2 2 2 1 mRNA capping enzyme, beta chain Pro_isomerase PF00160.21 AFZ80357.1 - 5.2e-50 169.8 0.1 6.8e-50 169.4 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD CPSF_A PF03178.15 AFZ80358.1 - 1.5e-41 142.8 1.8 1e-31 110.5 0.1 3.5 3 0 0 3 3 3 3 CPSF A subunit region MMS1_N PF10433.9 AFZ80358.1 - 5.1e-24 84.8 11.8 3.6e-23 81.9 9.1 3.0 2 1 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Utp21 PF04192.12 AFZ80359.1 - 2.2e-35 122.3 5.1 3.2e-35 121.7 5.1 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain ANAPC4_WD40 PF12894.7 AFZ80359.1 - 3.8e-10 39.9 0.3 0.15 12.4 0.0 6.3 4 3 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AFZ80359.1 - 7e-06 26.7 11.6 0.0024 18.6 0.0 6.1 6 0 0 6 6 6 2 WD domain, G-beta repeat UTP15_C PF09384.10 AFZ80359.1 - 0.00066 19.4 0.1 0.0012 18.5 0.1 1.3 1 0 0 1 1 1 1 UTP15 C terminal PQQ_2 PF13360.6 AFZ80359.1 - 0.0067 16.0 0.0 0.021 14.4 0.0 1.8 2 0 0 2 2 2 1 PQQ-like domain PQQ PF01011.21 AFZ80359.1 - 0.027 14.4 0.1 0.8 9.7 0.0 3.1 3 0 0 3 3 3 0 PQQ enzyme repeat Cpn60_TCP1 PF00118.24 AFZ80360.1 - 4.2e-148 494.0 19.2 4.8e-148 493.8 19.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family zf-CCCH_4 PF18044.1 AFZ80361.1 - 9.6e-05 22.1 2.1 0.00029 20.6 2.1 1.9 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 AFZ80361.1 - 0.0016 18.4 4.5 0.0055 16.7 4.5 2.0 1 0 0 1 1 1 1 Zinc finger domain WD40 PF00400.32 AFZ80361.1 - 0.0024 18.7 9.7 1.2 10.2 0.0 5.2 4 1 0 4 4 4 2 WD domain, G-beta repeat zf-CCCH PF00642.24 AFZ80361.1 - 0.02 14.8 1.4 0.02 14.8 1.4 2.4 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RAB3GAP2_N PF14655.6 AFZ80361.1 - 0.12 11.6 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus RRM_1 PF00076.22 AFZ80363.1 - 3.7e-14 52.3 0.0 6.3e-14 51.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AFZ80363.1 - 0.011 15.8 0.0 0.033 14.3 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif TPR_14 PF13428.6 AFZ80364.1 - 7.1e-05 23.3 0.0 12 7.0 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat Suf PF05843.14 AFZ80364.1 - 8.8e-05 22.6 7.4 0.011 15.7 0.4 3.9 2 2 1 3 3 3 1 Suppressor of forked protein (Suf) TPR_8 PF13181.6 AFZ80364.1 - 0.042 14.1 0.7 12 6.4 1.0 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat DUF1477 PF07346.11 AFZ80364.1 - 0.043 14.1 0.2 0.13 12.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1477) TPR_19 PF14559.6 AFZ80364.1 - 0.071 13.6 0.0 56 4.4 0.0 3.8 4 1 0 4 4 4 0 Tetratricopeptide repeat S1 PF00575.23 AFZ80365.1 - 9.4e-19 67.5 15.6 2.3e-12 47.1 0.2 5.6 5 1 0 5 5 5 3 S1 RNA binding domain Ten1 PF12658.7 AFZ80365.1 - 0.058 13.4 0.1 0.23 11.4 0.0 2.0 2 0 0 2 2 2 0 Telomere capping, CST complex subunit PCI PF01399.27 AFZ80366.1 - 0.00014 22.3 2.9 0.00042 20.8 0.0 3.3 3 0 0 3 3 3 1 PCI domain DUF3177 PF11375.8 AFZ80366.1 - 0.047 13.5 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3177) Dynein_light PF01221.18 AFZ80367.1 - 5.4e-39 132.4 1.4 6.2e-39 132.2 1.4 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 RNA_pol_Rpb8 PF03870.15 AFZ80368.1 - 1.6e-38 132.0 0.1 1.8e-38 131.8 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 AFZ80368.1 - 3.8e-06 27.0 0.2 0.00036 20.6 0.2 2.0 1 1 0 1 1 1 1 DNA-directed RNA polymerase, subunit G RBB1NT PF08169.11 AFZ80368.1 - 0.026 14.7 0.0 0.059 13.5 0.0 1.6 2 0 0 2 2 2 0 RBB1NT (NUC162) domain CelTOS PF18659.1 AFZ80369.1 - 2.6e-48 163.5 0.1 3.2e-48 163.2 0.1 1.1 1 0 0 1 1 1 1 Cell-traversal protein for ookinetes and sporozoites TnpW PF14202.6 AFZ80369.1 - 0.09 12.6 1.2 4.1 7.3 0.0 2.3 2 0 0 2 2 2 0 Transposon-encoded protein TnpW Sof1 PF04158.14 AFZ80370.1 - 1.8e-24 85.8 7.5 2.9e-24 85.1 7.5 1.3 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 AFZ80370.1 - 2.8e-19 69.1 19.9 0.00072 20.3 0.2 6.8 6 1 1 7 7 7 4 WD domain, G-beta repeat GPR15L PF15854.5 AFZ80370.1 - 0.19 12.0 1.7 0.63 10.3 1.7 1.9 1 0 0 1 1 1 0 G-protein coupled receptor ligand 15 HECT PF00632.25 AFZ80372.1 - 8.2e-93 311.2 0.1 4.4e-92 308.8 0.0 2.2 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) DUF913 PF06025.12 AFZ80372.1 - 1.3e-44 152.7 0.0 1.3e-44 152.7 0.0 3.1 3 0 0 3 3 3 1 Domain of Unknown Function (DUF913) DUF908 PF06012.12 AFZ80372.1 - 3.3e-33 115.6 11.2 3.6e-20 72.7 2.0 2.9 2 0 0 2 2 2 2 Domain of Unknown Function (DUF908) UBM PF14377.6 AFZ80372.1 - 1.5e-07 30.6 9.7 0.0025 17.2 0.1 4.4 4 0 0 4 4 4 3 Ubiquitin binding region EF-hand_1 PF00036.32 AFZ80373.1 - 8.5e-26 87.6 13.7 9.1e-07 28.0 0.7 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 AFZ80373.1 - 2.2e-24 85.7 10.1 1.5e-11 44.6 0.2 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 AFZ80373.1 - 3.4e-22 76.4 10.7 5.3e-06 25.9 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 AFZ80373.1 - 5.8e-18 64.5 17.2 2.7e-08 33.6 1.0 3.9 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 AFZ80373.1 - 5e-12 46.0 0.4 1.7e-05 25.0 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 AFZ80373.1 - 1.4e-10 40.2 11.0 0.0014 18.1 0.3 4.3 4 0 0 4 4 4 4 EF hand EF-hand_4 PF12763.7 AFZ80373.1 - 0.00026 20.9 6.4 0.19 11.7 0.0 3.4 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 AFZ80373.1 - 0.0011 18.9 1.9 6.3 6.7 0.0 3.9 1 1 3 4 4 4 1 Caleosin related protein EF-hand_14 PF17959.1 AFZ80373.1 - 0.0031 17.8 2.2 0.51 10.7 0.2 2.4 2 1 0 2 2 2 2 EF-hand domain TerB PF05099.13 AFZ80373.1 - 0.0058 16.6 0.9 2.5 8.0 0.1 2.8 1 1 3 4 4 4 1 Tellurite resistance protein TerB SurA_N_3 PF13624.6 AFZ80373.1 - 0.0071 16.1 0.7 0.15 11.8 0.2 2.1 2 0 0 2 2 2 1 SurA N-terminal domain SurA_N_2 PF13623.6 AFZ80373.1 - 0.032 14.1 0.1 1.4 8.8 0.0 2.2 2 0 0 2 2 2 0 SurA N-terminal domain DUF1636 PF07845.11 AFZ80373.1 - 0.094 13.2 0.0 5.7 7.4 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1636) DUF592 PF04574.13 AFZ80373.1 - 0.097 12.4 0.9 0.48 10.2 0.2 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF592) Tubulin_3 PF14881.6 AFZ80373.1 - 0.31 10.7 3.3 0.44 10.2 2.8 1.4 1 1 0 1 1 1 0 Tubulin domain DUF2220 PF09983.9 AFZ80374.1 - 3.5e-07 29.8 0.0 6.2e-07 29.0 0.0 1.5 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria C-term(DUF2220) DUF2399 PF09664.10 AFZ80374.1 - 0.00052 20.0 0.0 0.00099 19.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2399) Ubiq-assoc PF09145.10 AFZ80374.1 - 0.084 12.9 0.1 1.9 8.5 0.1 2.4 2 0 0 2 2 2 0 Ubiquitin-associated Cas9_PI2 PF18070.1 AFZ80374.1 - 0.087 13.6 0.6 1 10.1 0.0 2.3 2 0 0 2 2 2 0 CRISPR-Cas9 PI domain SHS2_Rpb7-N PF03876.17 AFZ80375.1 - 3e-15 56.3 0.1 4.9e-15 55.6 0.1 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 AFZ80375.1 - 1.2e-10 41.5 0.0 2e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 S1 RNA binding domain WD40_3 PF15911.5 AFZ80375.1 - 0.12 12.4 0.1 0.28 11.2 0.1 1.7 1 1 0 1 1 1 0 WD domain, G-beta repeat AhpC-TSA PF00578.21 AFZ80376.1 - 1.2e-18 67.2 0.0 1.6e-18 66.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AFZ80376.1 - 8.5e-14 51.5 0.0 1.1e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 Redoxin ABC_tran PF00005.27 AFZ80377.1 - 1.9e-29 102.9 0.0 5.4e-16 59.3 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_29 PF13555.6 AFZ80377.1 - 4.5e-05 23.1 1.2 0.12 12.1 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 AFZ80377.1 - 7.2e-05 22.7 1.1 0.14 11.9 0.1 3.6 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 AFZ80377.1 - 0.00015 22.2 0.0 0.11 12.9 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 AFZ80377.1 - 0.00026 20.8 0.2 0.25 11.0 0.0 2.3 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 AFZ80377.1 - 0.00087 19.2 0.3 0.083 12.8 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase Zeta_toxin PF06414.12 AFZ80377.1 - 0.0015 17.8 0.2 0.65 9.2 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin AAA_23 PF13476.6 AFZ80377.1 - 0.0027 18.2 2.1 2.4 8.6 0.6 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 AFZ80377.1 - 0.0032 17.8 0.1 1.2 9.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain DnaB_C PF03796.15 AFZ80377.1 - 0.0046 16.3 0.0 0.21 10.9 0.0 2.2 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_18 PF13238.6 AFZ80377.1 - 0.0072 16.9 0.1 3 8.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 AFZ80377.1 - 0.009 15.0 0.3 0.025 13.6 0.0 1.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 AFZ80377.1 - 0.016 15.3 0.3 0.22 11.6 0.1 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 AFZ80377.1 - 0.018 14.4 0.3 2.7 7.3 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family SMC_N PF02463.19 AFZ80377.1 - 0.026 14.0 0.3 0.44 9.9 0.1 2.6 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain T2SSE PF00437.20 AFZ80377.1 - 0.031 13.4 1.7 2.8 6.9 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein ATPase_2 PF01637.18 AFZ80377.1 - 0.037 13.9 0.0 12 5.7 0.0 2.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea cobW PF02492.19 AFZ80377.1 - 0.055 13.1 0.6 7.3 6.1 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 AFZ80377.1 - 0.081 12.8 0.6 15 5.4 0.0 2.6 2 0 0 2 2 2 0 NACHT domain ATP_bind_1 PF03029.17 AFZ80377.1 - 0.091 12.5 0.1 10 5.8 0.0 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DUF87 PF01935.17 AFZ80377.1 - 0.1 12.7 2.1 0.15 12.1 0.1 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain SbcCD_C PF13558.6 AFZ80377.1 - 0.14 12.4 0.0 0.33 11.2 0.0 1.6 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit NB-ARC PF00931.22 AFZ80377.1 - 0.2 10.8 1.7 1.2 8.2 0.0 2.5 3 0 0 3 3 3 0 NB-ARC domain AAA_25 PF13481.6 AFZ80377.1 - 0.22 11.1 0.1 5 6.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain FAINT PF04385.15 AFZ80378.1 - 4.5e-05 23.4 0.1 0.17 12.0 0.1 2.6 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Rsm22 PF09243.10 AFZ80381.1 - 1.1e-66 224.9 0.0 2e-66 224.1 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 Acyltransferase PF01553.21 AFZ80382.1 - 1.3e-15 57.2 0.0 7.2e-15 54.8 0.0 2.0 1 1 0 1 1 1 1 Acyltransferase RseC_MucC PF04246.12 AFZ80382.1 - 0.0047 16.9 2.9 1.2 9.1 0.0 2.5 2 0 0 2 2 2 2 Positive regulator of sigma(E), RseC/MucC Fis1_TPR_C PF14853.6 AFZ80383.1 - 2e-13 50.2 5.6 3.4e-07 30.2 0.7 2.4 1 1 1 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_1 PF00515.28 AFZ80383.1 - 2.8e-11 42.7 8.9 0.00064 19.4 0.7 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 AFZ80383.1 - 6.8e-11 41.4 4.7 0.0056 16.7 0.3 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 AFZ80383.1 - 8.5e-08 31.8 7.0 0.002 18.2 0.6 3.6 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 AFZ80383.1 - 9.3e-08 32.5 0.1 2e-06 28.2 0.1 2.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 AFZ80383.1 - 2e-05 24.3 0.8 0.58 10.3 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 AFZ80383.1 - 0.00036 21.0 0.4 1.4 9.7 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat MIT PF04212.18 AFZ80383.1 - 0.00043 20.3 0.6 0.15 12.1 0.5 3.0 3 1 0 3 3 3 1 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 AFZ80383.1 - 0.0012 19.5 0.0 1.7 9.7 0.0 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 AFZ80383.1 - 0.0012 19.0 4.4 0.0057 16.9 4.8 1.8 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 AFZ80383.1 - 0.0013 18.9 2.2 0.38 11.1 0.2 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 AFZ80383.1 - 0.0071 16.0 1.8 0.32 10.7 0.0 3.1 3 0 0 3 3 3 1 TPR repeat TPR_10 PF13374.6 AFZ80383.1 - 0.0094 15.8 0.2 4 7.4 0.1 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat YfiO PF13525.6 AFZ80383.1 - 0.064 13.0 1.2 0.2 11.4 0.5 1.9 1 1 1 2 2 2 0 Outer membrane lipoprotein TPR_17 PF13431.6 AFZ80383.1 - 0.14 12.6 5.7 2 9.0 0.3 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat SseC PF04888.12 AFZ80383.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family TMEM208_SND2 PF05620.11 AFZ80384.1 - 3.4e-10 39.9 1.6 1.9e-08 34.3 1.6 2.0 1 1 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 EF-hand_7 PF13499.6 AFZ80385.1 - 5.5e-26 90.8 6.4 5.7e-10 39.5 1.2 4.8 4 1 1 5 5 4 4 EF-hand domain pair Metallophos PF00149.28 AFZ80385.1 - 7.9e-23 82.0 0.9 1.6e-22 81.0 0.9 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase EF-hand_1 PF00036.32 AFZ80385.1 - 1.8e-16 58.4 3.5 0.0047 16.4 0.1 7.2 7 0 0 7 7 7 3 EF hand EF-hand_6 PF13405.6 AFZ80385.1 - 1.8e-14 52.3 7.3 0.2 11.7 0.0 8.2 8 0 0 8 8 8 4 EF-hand domain EF-hand_8 PF13833.6 AFZ80385.1 - 1.9e-09 37.2 4.7 0.0014 18.4 0.1 4.9 4 2 0 4 4 4 3 EF-hand domain pair CAP_GLY PF01302.25 AFZ80385.1 - 2.1e-05 24.4 0.1 6.4e-05 22.9 0.1 1.9 2 0 0 2 2 2 1 CAP-Gly domain EF-hand_5 PF13202.6 AFZ80385.1 - 0.0015 17.9 6.2 8.5 6.1 0.0 6.1 8 0 0 8 8 8 2 EF hand Dockerin_1 PF00404.18 AFZ80385.1 - 0.012 15.8 0.0 34 4.7 0.0 4.1 4 0 0 4 4 4 0 Dockerin type I domain IQ PF00612.27 AFZ80385.1 - 0.013 15.2 0.1 0.031 14.1 0.1 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif DUF5580 PF17743.1 AFZ80385.1 - 0.023 13.3 0.0 0.044 12.3 0.0 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5580) Caleosin PF05042.13 AFZ80385.1 - 0.043 13.8 0.6 20 5.1 0.0 3.7 5 0 0 5 5 5 0 Caleosin related protein Gp37 PF09646.10 AFZ80385.1 - 0.051 13.4 0.0 12 5.7 0.0 2.4 2 0 0 2 2 2 0 Gp37 protein TGT_C2 PF14810.6 AFZ80387.1 - 0.0056 16.8 0.0 2.9 8.1 0.0 2.4 2 0 0 2 2 2 2 Patch-forming domain C2 of tRNA-guanine transglycosylase Phosphodiest PF01663.22 AFZ80390.1 - 0.0039 16.8 0.1 0.0085 15.7 0.1 1.5 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 AFZ80390.1 - 0.005 16.3 0.1 0.034 13.5 0.0 2.2 2 0 0 2 2 2 1 Sulfatase Phage_HK97_TLTM PF06120.11 AFZ80391.1 - 0.021 14.0 0.0 0.025 13.8 0.0 1.0 1 0 0 1 1 1 0 Tail length tape measure protein Hexapep PF00132.24 AFZ80392.1 - 1.5e-07 30.8 9.1 7.8e-05 22.2 2.4 3.0 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 AFZ80392.1 - 0.00048 19.2 0.5 0.00048 19.2 0.5 1.6 2 0 0 2 2 2 1 L-fucokinase Hexapep_2 PF14602.6 AFZ80392.1 - 4.1 7.2 8.8 5 7.0 2.5 2.9 1 1 2 3 3 3 0 Hexapeptide repeat of succinyl-transferase Band_7 PF01145.25 AFZ80394.1 - 2.4e-23 83.1 0.8 5.6e-23 81.9 0.2 1.7 2 0 0 2 2 2 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 AFZ80394.1 - 0.0064 15.6 1.3 0.0082 15.3 1.3 1.2 1 0 0 1 1 1 1 SigmaW regulon antibacterial Proteasome PF00227.26 AFZ80395.1 - 7.1e-33 113.7 0.0 8.9e-33 113.4 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit PB1 PF00564.24 AFZ80395.1 - 0.18 11.8 0.4 1.5 8.8 0.1 2.3 2 0 0 2 2 2 0 PB1 domain SRP72 PF08492.12 AFZ80396.1 - 7.4e-08 32.7 6.2 7.4e-08 32.7 6.2 2.6 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_14 PF13428.6 AFZ80396.1 - 1.2e-06 28.9 0.0 3.1 8.9 0.0 5.7 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 AFZ80396.1 - 1.2e-06 28.9 0.8 2.1 8.9 0.0 6.0 6 1 1 7 7 7 1 Tetratricopeptide repeat SRP_TPR_like PF17004.5 AFZ80396.1 - 3.9e-06 26.9 4.0 0.019 15.0 0.1 4.5 2 2 0 3 3 3 2 Putative TPR-like repeat TPR_12 PF13424.6 AFZ80396.1 - 9.9e-06 25.8 4.8 12 6.3 0.0 6.5 6 0 0 6 6 6 0 Tetratricopeptide repeat ANAPC3 PF12895.7 AFZ80396.1 - 0.00015 22.0 20.9 5.3 7.3 0.4 6.6 6 1 0 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.14 AFZ80396.1 - 0.014 15.9 0.0 0.62 10.8 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_MalT PF17874.1 AFZ80396.1 - 0.017 14.5 0.0 0.23 10.8 0.0 2.8 3 0 0 3 3 3 0 MalT-like TPR region TPR_6 PF13174.6 AFZ80396.1 - 0.02 15.5 11.8 56 4.7 0.0 6.9 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.6 AFZ80396.1 - 0.021 15.5 1.0 46 4.8 0.0 4.3 5 0 0 5 5 4 0 Tetratricopeptide repeat TAF1_subA PF14929.6 AFZ80396.1 - 0.025 14.0 0.4 0.59 9.5 0.1 2.5 2 1 0 2 2 2 0 TAF RNA Polymerase I subunit A TPR_17 PF13431.6 AFZ80396.1 - 0.028 14.8 5.5 1.7 9.2 0.1 4.8 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 AFZ80396.1 - 0.028 14.5 24.2 4.5 7.6 0.4 6.7 6 0 0 6 6 6 0 Tetratricopeptide repeat PPR_2 PF13041.6 AFZ80396.1 - 0.071 13.3 0.7 18 5.6 0.0 4.0 4 0 0 4 4 4 0 PPR repeat family TPR_15 PF13429.6 AFZ80396.1 - 0.083 12.1 0.1 1.1 8.5 0.1 2.2 1 1 0 1 1 1 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 AFZ80396.1 - 0.18 11.7 0.1 7 6.5 0.0 2.7 3 0 0 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal PPR PF01535.20 AFZ80396.1 - 0.23 11.8 6.6 4.6 7.7 0.1 5.4 6 0 0 6 6 6 0 PPR repeat TPR_8 PF13181.6 AFZ80396.1 - 6.9 7.2 26.9 5.3 7.5 3.1 6.6 8 0 0 8 8 7 0 Tetratricopeptide repeat MutS_V PF00488.21 AFZ80397.1 - 1.6e-70 237.0 1.5 3.5e-70 235.9 1.5 1.5 1 0 0 1 1 1 1 MutS domain V MutS_I PF01624.20 AFZ80397.1 - 7.4e-33 113.2 0.2 4.1e-32 110.8 0.0 2.2 2 0 0 2 2 2 1 MutS domain I MutS_III PF05192.18 AFZ80397.1 - 3.7e-31 108.9 0.9 3.7e-31 108.9 0.9 2.6 3 0 0 3 3 3 1 MutS domain III NB-ARC PF00931.22 AFZ80397.1 - 0.0012 18.1 0.1 0.0039 16.4 0.1 1.8 1 0 0 1 1 1 1 NB-ARC domain AAA_29 PF13555.6 AFZ80397.1 - 0.019 14.7 0.1 0.075 12.8 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_23 PF13476.6 AFZ80397.1 - 0.019 15.4 0.0 0.019 15.4 0.0 3.5 3 1 0 3 3 2 0 AAA domain MutS_II PF05188.17 AFZ80397.1 - 0.031 14.5 0.2 0.21 11.9 0.0 2.6 2 0 0 2 2 2 0 MutS domain II ABC_ATPase PF09818.9 AFZ80397.1 - 0.033 13.0 0.1 0.068 12.0 0.1 1.5 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_14 PF13173.6 AFZ80397.1 - 0.045 13.8 0.4 0.67 10.0 0.0 3.1 2 1 1 3 3 3 0 AAA domain AAA_28 PF13521.6 AFZ80397.1 - 0.088 13.0 0.5 3.2 8.0 0.1 2.6 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 AFZ80397.1 - 0.13 12.5 0.0 1.1 9.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain CLTH PF10607.9 AFZ80398.1 - 5.8e-24 84.7 0.4 7.6e-24 84.3 0.4 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain Flt3_lig PF02947.14 AFZ80398.1 - 0.064 13.4 0.2 0.79 9.9 0.1 2.3 2 0 0 2 2 2 0 flt3 ligand Utp12 PF04003.12 AFZ80399.1 - 1.5e-17 63.9 0.7 2.3e-17 63.2 0.7 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family Ribosomal_S11 PF00411.19 AFZ80400.1 - 0.0001 22.7 0.1 0.00014 22.2 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S11 Ribosomal_L18p PF00861.22 AFZ80400.1 - 0.00032 21.1 0.1 0.00068 20.0 0.1 1.6 1 1 0 1 1 1 1 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast FAINT PF04385.15 AFZ80401.1 - 1.3e-43 147.0 29.0 6.7e-08 32.5 1.4 8.7 8 0 0 8 8 8 8 Domain of unknown function, DUF529 OSTMP1 PF09777.9 AFZ80401.1 - 0.03 13.7 0.3 0.081 12.3 0.3 1.7 1 0 0 1 1 1 0 Osteopetrosis-associated transmembrane protein 1 precursor Runt PF00853.19 AFZ80401.1 - 0.096 12.2 0.0 1.6 8.3 0.0 2.4 2 0 0 2 2 2 0 Runt domain Lactamase_B_2 PF12706.7 AFZ80402.1 - 2.5e-13 50.0 0.0 3.4e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 AFZ80402.1 - 6.9e-08 32.5 0.0 1.2e-07 31.7 0.0 1.3 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Cpn10 PF00166.21 AFZ80403.1 - 2.1e-27 95.0 0.0 2.3e-27 94.9 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Pro_isomerase PF00160.21 AFZ80404.1 - 2.2e-21 76.8 0.0 3.1e-21 76.3 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD NifU_N PF01592.16 AFZ80405.1 - 2.9e-48 163.2 0.1 3.4e-48 163.0 0.1 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain RNase_P_Rpp14 PF01900.19 AFZ80406.1 - 1.1e-13 51.3 0.2 1.3e-13 51.0 0.2 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family Glu-tRNAGln PF02686.15 AFZ80406.1 - 0.13 12.6 0.1 4.7 7.6 0.0 2.7 3 0 0 3 3 3 0 Glu-tRNAGln amidotransferase C subunit UFD1 PF03152.14 AFZ80407.1 - 5.9e-09 35.6 0.0 6.1e-09 35.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 GAS PF13851.6 AFZ80409.1 - 0.00071 19.0 0.6 0.0016 17.9 0.6 1.5 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding 6PGD PF00393.19 AFZ80410.1 - 2.9e-82 276.3 0.0 3.8e-82 275.9 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 AFZ80410.1 - 1.7e-31 109.5 0.0 3.6e-31 108.5 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Actin PF00022.19 AFZ80411.1 - 7.9e-53 179.5 0.0 6.7e-46 156.7 0.0 2.1 2 0 0 2 2 2 2 Actin MreB_Mbl PF06723.13 AFZ80411.1 - 0.00048 19.0 0.1 0.21 10.3 0.1 2.2 2 0 0 2 2 2 2 MreB/Mbl protein DUF2164 PF09932.9 AFZ80411.1 - 0.094 12.8 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2164) Alg14 PF08660.11 AFZ80414.1 - 6.5e-33 114.1 0.0 1.1e-32 113.4 0.0 1.3 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like Mid2 PF04478.12 AFZ80414.1 - 0.046 13.6 0.2 0.068 13.0 0.2 1.2 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor PglD_N PF17836.1 AFZ80414.1 - 0.086 13.5 0.0 0.16 12.7 0.0 1.4 1 0 0 1 1 1 0 PglD N-terminal domain MMR_HSR1 PF01926.23 AFZ80415.1 - 1.1e-15 57.7 0.0 1.8e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AFZ80415.1 - 0.0001 22.3 0.1 0.006 16.5 0.0 2.4 2 1 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 AFZ80415.1 - 0.00026 20.6 0.0 0.17 11.4 0.0 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B Dynamin_N PF00350.23 AFZ80415.1 - 0.0006 19.9 0.0 0.23 11.5 0.2 2.3 1 1 0 2 2 2 2 Dynamin family GTP_EFTU PF00009.27 AFZ80415.1 - 0.0015 18.1 0.0 0.66 9.5 0.0 2.2 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain SRPRB PF09439.10 AFZ80415.1 - 0.059 12.8 0.0 0.19 11.1 0.0 1.8 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Septin PF00735.18 AFZ80415.1 - 0.1 11.9 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 Septin Ribosomal_L13e PF01294.18 AFZ80417.1 - 2.2e-60 203.6 2.0 2.7e-60 203.3 2.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e Ribosomal_S9 PF00380.19 AFZ80418.1 - 3.7e-31 108.2 0.2 4.3e-31 107.9 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 ATP-synt PF00231.19 AFZ80419.1 - 1.2e-83 281.0 4.5 1.4e-83 280.8 4.5 1.0 1 0 0 1 1 1 1 ATP synthase Sec5 PF15469.6 AFZ80419.1 - 4.6 7.0 6.0 16 5.2 0.3 3.1 3 1 1 4 4 4 0 Exocyst complex component Sec5 WD40 PF00400.32 AFZ80420.1 - 1.7e-26 91.9 10.5 2.7e-08 34.3 0.2 6.6 7 0 0 7 7 7 4 WD domain, G-beta repeat LisH_TPL PF17814.1 AFZ80420.1 - 2.8e-13 49.3 0.2 1.1e-12 47.4 0.2 2.0 1 0 0 1 1 1 1 LisH-like dimerisation domain ANAPC4_WD40 PF12894.7 AFZ80420.1 - 1e-12 48.2 0.1 0.0036 17.6 0.0 5.0 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 AFZ80420.1 - 5.4e-05 22.3 0.1 0.017 14.1 0.0 3.1 1 1 2 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 AFZ80420.1 - 0.0061 16.5 0.0 0.17 11.8 0.0 2.9 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 AFZ80420.1 - 0.021 13.5 0.6 1.9 7.0 0.0 2.5 2 1 1 3 3 3 0 Nucleoporin Nup120/160 LisH PF08513.11 AFZ80420.1 - 0.026 14.5 0.0 0.057 13.4 0.0 1.5 1 0 0 1 1 1 0 LisH DUF4394 PF14339.6 AFZ80420.1 - 0.037 13.4 0.0 0.079 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4394) Ndc80_HEC PF03801.13 AFZ80421.1 - 6.9e-17 61.5 0.9 1.7e-16 60.2 0.1 2.0 2 0 0 2 2 2 1 HEC/Ndc80p family PMEI PF04043.15 AFZ80421.1 - 0.015 15.6 1.1 0.05 13.9 1.1 1.9 1 0 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor DUF1192 PF06698.11 AFZ80421.1 - 0.1 12.7 7.2 0.43 10.7 0.2 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF1192) Apolipoprotein PF01442.18 AFZ80421.1 - 0.31 10.9 13.2 1.1 9.1 7.7 3.3 1 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain Atg14 PF10186.9 AFZ80421.1 - 0.41 9.7 28.9 0.3 10.1 6.8 3.9 1 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1664 PF07889.12 AFZ80421.1 - 0.49 10.4 21.0 1 9.4 0.2 4.6 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) DivIC PF04977.15 AFZ80421.1 - 0.58 10.0 0.0 0.58 10.0 0.0 5.4 3 3 1 5 5 5 0 Septum formation initiator TPR_MLP1_2 PF07926.12 AFZ80421.1 - 0.74 9.9 25.4 0.44 10.6 0.8 4.3 3 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.9 AFZ80421.1 - 0.84 9.7 32.9 1.9 8.5 7.0 4.3 2 2 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DHR10 PF18595.1 AFZ80421.1 - 1.6 8.8 25.3 0.21 11.6 1.4 4.6 2 2 2 4 4 4 0 Designed helical repeat protein 10 domain DUF1515 PF07439.11 AFZ80421.1 - 1.9 8.6 5.4 47 4.1 0.1 3.9 3 1 2 5 5 5 0 Protein of unknown function (DUF1515) DUF848 PF05852.11 AFZ80421.1 - 2.8 8.0 19.8 0.046 13.8 1.3 4.2 2 2 0 4 4 4 0 Gammaherpesvirus protein of unknown function (DUF848) DUF16 PF01519.16 AFZ80421.1 - 4.3 7.9 16.3 3.6 8.1 0.0 3.9 2 2 0 3 3 3 0 Protein of unknown function DUF16 Nmad5 PF18757.1 AFZ80421.1 - 4.5 7.4 13.3 0.76 9.9 6.0 2.5 2 1 0 2 2 2 0 Nucleotide modification associated domain 5 Endotoxin_N PF03945.14 AFZ80421.1 - 7.9 6.1 11.9 0.29 10.8 1.8 3.0 2 2 1 4 4 4 0 delta endotoxin, N-terminal domain YlbD_coat PF14071.6 AFZ80421.1 - 8.5 6.6 13.9 6.3 7.1 0.3 3.3 2 1 1 3 3 3 0 Putative coat protein IMD PF08397.11 AFZ80421.1 - 8.6 5.7 14.7 0.032 13.6 1.6 2.8 2 1 1 3 3 3 0 IRSp53/MIM homology domain DUF2254 PF10011.9 AFZ80422.1 - 0.011 14.6 0.0 0.018 13.9 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) YqzE PF14038.6 AFZ80422.1 - 0.048 13.7 0.6 0.13 12.3 0.1 2.0 2 0 0 2 2 2 0 YqzE-like protein GP41 PF00517.17 AFZ80422.1 - 0.059 13.3 0.1 0.093 12.6 0.1 1.4 1 0 0 1 1 1 0 Retroviral envelope protein IER PF05760.12 AFZ80422.1 - 0.22 11.8 4.9 0.44 10.8 4.9 1.4 1 0 0 1 1 1 0 Immediate early response protein (IER) SDA1 PF05285.12 AFZ80422.1 - 0.71 9.2 8.2 1 8.7 8.2 1.1 1 0 0 1 1 1 0 SDA1 ABC2_membrane_3 PF12698.7 AFZ80422.1 - 3.3 6.7 5.7 2.7 7.0 4.2 1.5 2 0 0 2 2 2 0 ABC-2 family transporter protein DUF1674 PF07896.12 AFZ80423.1 - 1.9e-06 28.2 0.4 3.9e-06 27.2 0.4 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) Bromodomain PF00439.25 AFZ80425.1 - 5.7e-14 52.0 0.0 1.6e-13 50.5 0.0 1.9 1 0 0 1 1 1 1 Bromodomain PBP1_TM PF14812.6 AFZ80425.1 - 0.25 11.8 6.6 0.38 11.2 0.1 2.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Drf_GBD PF06371.13 AFZ80425.1 - 0.45 10.1 0.0 0.45 10.1 0.0 1.8 3 0 0 3 3 3 0 Diaphanous GTPase-binding Domain Fer4_17 PF13534.6 AFZ80426.1 - 1.2e-07 32.2 8.0 2.7e-07 31.0 8.0 1.7 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 AFZ80426.1 - 1.3e-05 25.2 7.4 3.5e-05 23.8 7.4 1.7 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 AFZ80426.1 - 6.8e-05 23.2 7.0 0.00018 21.9 7.0 1.8 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 AFZ80426.1 - 0.04 14.5 7.0 0.14 12.8 7.0 2.0 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_9 PF13187.6 AFZ80426.1 - 0.44 10.8 7.5 1.3 9.3 7.5 1.8 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer2_3 PF13085.6 AFZ80427.1 - 1.3e-31 108.8 0.1 1.8e-31 108.4 0.1 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2 PF00111.27 AFZ80427.1 - 0.0018 18.2 2.7 0.0023 17.8 1.3 1.9 2 1 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Methyltransf_25 PF13649.6 AFZ80428.1 - 5.4e-05 23.8 0.1 0.014 16.1 0.0 2.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 AFZ80428.1 - 0.00015 21.6 0.5 0.0044 16.8 0.1 2.5 2 1 0 2 2 2 1 Methyltransferase domain Spermine_synth PF01564.17 AFZ80428.1 - 0.00025 20.5 0.2 0.0018 17.7 0.1 2.3 2 0 0 2 2 2 1 Spermine/spermidine synthase domain Methyltransf_11 PF08241.12 AFZ80428.1 - 0.0069 17.0 0.0 0.082 13.6 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 AFZ80428.1 - 0.0093 16.7 0.1 0.46 11.3 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_33 PF10017.9 AFZ80428.1 - 0.017 14.3 0.0 0.19 10.9 0.0 2.4 3 0 0 3 3 3 0 Histidine-specific methyltransferase, SAM-dependent Helicase_C PF00271.31 AFZ80429.1 - 2.8e-11 43.7 1.1 1.5e-10 41.3 0.1 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 AFZ80429.1 - 5.3e-10 39.3 0.0 1.6e-08 34.5 0.0 2.5 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 AFZ80429.1 - 1.3e-05 25.3 0.7 1.3e-05 25.3 0.7 2.3 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit ARL2_Bind_BART PF11527.8 AFZ80429.1 - 1.8 8.7 5.5 0.4 10.8 0.1 2.7 3 0 0 3 3 3 0 The ARF-like 2 binding protein BART RF-1 PF00472.20 AFZ80430.1 - 4.6e-15 55.6 0.8 8.6e-15 54.7 0.8 1.4 1 0 0 1 1 1 1 RF-1 domain P53 PF00870.18 AFZ80430.1 - 0.059 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 P53 DNA-binding domain BCIP PF13862.6 AFZ80431.1 - 4.5e-39 134.4 0.2 6.7e-39 133.8 0.2 1.2 1 0 0 1 1 1 1 p21-C-terminal region-binding protein Intein_splicing PF14890.6 AFZ80431.1 - 0.075 13.0 0.1 0.19 11.7 0.0 1.7 1 1 0 1 1 1 0 Intein splicing domain DUF4661 PF15576.6 AFZ80432.1 - 0.13 12.2 0.8 0.23 11.4 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) CNH PF00780.22 AFZ80433.1 - 1.2e-09 38.2 1.7 4.9e-09 36.2 0.3 2.6 2 1 0 2 2 2 1 CNH domain Vps39_2 PF10367.9 AFZ80433.1 - 8.7e-09 35.8 0.0 2.7e-08 34.2 0.0 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 FAINT PF04385.15 AFZ80435.1 - 7.5e-05 22.7 0.8 0.00019 21.5 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ80436.1 - 1.9e-08 34.3 4.0 0.00059 19.8 0.0 3.8 3 0 0 3 3 3 3 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ80437.1 - 8.3e-08 32.2 0.1 2.2e-05 24.4 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 RHH_7 PF16777.5 AFZ80437.1 - 0.24 11.8 1.3 0.92 9.9 0.0 2.3 2 0 0 2 2 2 0 Transcriptional regulator, RHH-like, CopG ABC_tran PF00005.27 AFZ80438.1 - 6.6e-31 107.6 0.0 3.4e-17 63.2 0.0 2.6 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 AFZ80438.1 - 5.5e-06 26.4 0.6 0.033 14.0 0.1 3.0 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 AFZ80438.1 - 9.2e-05 22.1 1.5 0.12 12.2 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 AFZ80438.1 - 0.00012 22.5 0.0 0.097 13.1 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 AFZ80438.1 - 0.0002 21.2 1.0 0.067 12.9 0.1 2.3 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 AFZ80438.1 - 0.00052 20.0 1.0 0.022 14.7 0.2 2.4 2 0 0 2 2 2 1 RsgA GTPase Zeta_toxin PF06414.12 AFZ80438.1 - 0.00059 19.2 0.6 0.11 11.8 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_23 PF13476.6 AFZ80438.1 - 0.002 18.6 5.8 0.28 11.6 0.2 2.7 3 0 0 3 3 2 2 AAA domain MeaB PF03308.16 AFZ80438.1 - 0.0028 16.7 0.1 0.0028 16.7 0.1 1.6 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 AFZ80438.1 - 0.0083 16.2 0.5 0.079 13.0 0.1 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase DnaB_C PF03796.15 AFZ80438.1 - 0.0089 15.4 0.1 0.12 11.7 0.0 2.2 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain SMC_N PF02463.19 AFZ80438.1 - 0.012 15.1 0.1 0.35 10.3 0.0 2.6 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_18 PF13238.6 AFZ80438.1 - 0.012 16.1 0.4 6.5 7.3 0.1 2.7 2 0 0 2 2 2 0 AAA domain Fer4_NifH PF00142.18 AFZ80438.1 - 0.02 14.4 0.6 2.6 7.4 0.1 2.3 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family FtsK_SpoIIIE PF01580.18 AFZ80438.1 - 0.031 13.7 1.2 3.4 6.9 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF87 PF01935.17 AFZ80438.1 - 0.042 13.9 3.3 0.096 12.8 0.6 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_25 PF13481.6 AFZ80438.1 - 0.05 13.2 0.1 2.7 7.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 AFZ80438.1 - 0.052 12.7 1.5 0.39 9.8 0.1 2.5 2 0 0 2 2 2 0 NB-ARC domain T2SSE PF00437.20 AFZ80438.1 - 0.065 12.3 1.0 8 5.4 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF2791 PF10923.8 AFZ80438.1 - 0.066 12.0 0.1 0.81 8.5 0.0 2.2 2 0 0 2 2 2 0 P-loop Domain of unknown function (DUF2791) AAA_22 PF13401.6 AFZ80438.1 - 0.067 13.5 1.3 6.7 7.0 0.1 2.5 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 AFZ80438.1 - 0.11 12.4 0.7 7.1 6.5 0.1 2.5 2 0 0 2 2 2 0 NTPase Dynamin_N PF00350.23 AFZ80438.1 - 0.15 12.1 0.6 23 5.0 0.1 2.5 2 0 0 2 2 2 0 Dynamin family cobW PF02492.19 AFZ80438.1 - 0.16 11.5 2.1 12 5.5 0.2 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 AFZ80438.1 - 0.17 12.1 0.4 15 5.7 0.1 2.6 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 AFZ80438.1 - 0.17 11.6 0.4 18 4.9 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain NACHT PF05729.12 AFZ80438.1 - 0.19 11.7 2.4 6.6 6.6 0.1 2.4 2 0 0 2 2 2 0 NACHT domain TsaE PF02367.17 AFZ80438.1 - 0.26 11.3 1.4 6.9 6.7 0.1 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MobB PF03205.14 AFZ80438.1 - 0.4 10.6 1.7 9.4 6.1 0.3 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B SRP54 PF00448.22 AFZ80438.1 - 0.61 9.7 1.9 4.9 6.7 0.0 2.8 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain TrwB_AAD_bind PF10412.9 AFZ80438.1 - 0.91 8.4 2.4 17 4.1 0.3 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain OAD_gamma PF04277.13 AFZ80439.1 - 0.096 13.3 2.5 0.66 10.6 0.1 3.2 4 0 0 4 4 4 0 Oxaloacetate decarboxylase, gamma chain LapA_dom PF06305.11 AFZ80439.1 - 1.6 8.6 0.0 1.6 8.6 0.0 3.3 4 0 0 4 4 4 0 Lipopolysaccharide assembly protein A domain Prenyltrans PF00432.21 AFZ80440.1 - 1.4e-18 66.3 6.9 1.5e-06 27.8 0.0 5.1 5 0 0 5 5 5 4 Prenyltransferase and squalene oxidase repeat Rab5ip PF07019.12 AFZ80441.1 - 4.9e-08 33.4 11.0 2.9e-07 31.0 11.0 1.9 1 1 0 1 1 1 1 Rab5-interacting protein (Rab5ip) Fer2 PF00111.27 AFZ80443.1 - 2.9e-10 39.9 1.9 3.9e-10 39.5 1.9 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NifU PF01106.17 AFZ80443.1 - 0.064 13.4 0.1 0.26 11.5 0.1 2.0 2 0 0 2 2 2 0 NifU-like domain MCR PF18509.1 AFZ80443.1 - 0.79 9.4 5.4 0.4 10.3 2.6 2.0 1 1 1 2 2 2 0 Magnetochrome domain ABM PF03992.16 AFZ80444.1 - 0.084 13.0 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Antibiotic biosynthesis monooxygenase GOLD_2 PF13897.6 AFZ80446.1 - 0.11 13.0 3.5 0.12 12.9 3.5 1.1 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking TMEM40 PF15817.5 AFZ80447.1 - 0.16 11.7 0.8 0.36 10.6 0.8 1.6 1 0 0 1 1 1 0 Transmembrane protein 40 family DUF3481 PF11980.8 AFZ80447.1 - 0.99 9.1 4.1 0.5 10.1 0.7 2.2 2 0 0 2 2 2 0 C-terminal domain of neuropilin glycoprotein PHO4 PF01384.20 AFZ80447.1 - 1.8 7.6 11.0 4.1 6.3 11.0 1.6 1 1 0 1 1 1 0 Phosphate transporter family AhpC-TSA PF00578.21 AFZ80448.1 - 2.2e-26 92.2 0.0 2.9e-26 91.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AFZ80448.1 - 9.6e-12 44.8 0.0 1.3e-11 44.4 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 AFZ80448.1 - 9.8e-10 38.1 0.0 2.6e-09 36.7 0.0 1.7 2 0 0 2 2 2 1 C-terminal domain of 1-Cys peroxiredoxin FAINT PF04385.15 AFZ80449.1 - 3.6e-05 23.7 0.0 0.059 13.4 0.0 2.9 2 1 1 3 3 3 2 Domain of unknown function, DUF529 EMA PF02488.15 AFZ80449.1 - 0.006 16.3 0.5 0.11 12.1 0.2 2.1 2 0 0 2 2 2 1 Merozoite Antigen DUF3787 PF12655.7 AFZ80449.1 - 0.065 13.2 0.1 0.16 11.9 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3787) Podoplanin PF05808.11 AFZ80450.1 - 0.018 15.1 0.0 0.035 14.2 0.0 1.4 1 0 0 1 1 1 0 Podoplanin AAA_23 PF13476.6 AFZ80454.1 - 0.13 12.7 4.3 0.35 11.3 4.3 2.0 1 1 0 1 1 1 0 AAA domain MFS_1 PF07690.16 AFZ80455.1 - 4.5e-26 91.6 39.1 1.6e-24 86.5 26.9 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Baculo_11_kDa PF06143.11 AFZ80455.1 - 0.14 11.8 0.1 0.14 11.8 0.1 2.0 2 0 0 2 2 2 0 Baculovirus 11 kDa family ProRS-C_1 PF09180.11 AFZ80456.1 - 6e-25 87.2 0.0 1.3e-24 86.1 0.0 1.6 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA_edit PF04073.15 AFZ80456.1 - 6.1e-24 84.5 0.0 1.1e-23 83.7 0.0 1.4 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain tRNA-synt_2b PF00587.25 AFZ80456.1 - 1.7e-20 73.7 0.0 4.5e-20 72.4 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 AFZ80456.1 - 4.5e-20 71.6 0.6 1.7e-19 69.7 0.0 2.3 3 0 0 3 3 3 1 Anticodon binding domain MACPF PF01823.19 AFZ80458.1 - 5.5e-44 150.8 1.8 1.1e-43 149.8 1.8 1.5 1 0 0 1 1 1 1 MAC/Perforin domain SRP19 PF01922.17 AFZ80459.1 - 5.1e-29 101.1 0.0 7.1e-29 100.6 0.0 1.2 1 0 0 1 1 1 1 SRP19 protein tRNA-synt_2b PF00587.25 AFZ80460.1 - 1.2e-27 97.0 0.0 2.7e-27 95.9 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Mpp10 PF04006.12 AFZ80461.1 - 7e-33 114.0 60.0 4e-32 111.4 55.0 2.4 1 1 1 2 2 2 2 Mpp10 protein MORN PF02493.20 AFZ80463.1 - 2.9e-84 272.2 95.8 9.9e-09 34.6 2.2 14.3 14 0 0 14 14 14 14 MORN repeat DUF3048_C PF17479.2 AFZ80463.1 - 5.7e-05 23.5 31.7 0.34 11.3 0.7 7.2 1 1 6 7 7 7 4 Protein of unknown function (DUF3048) C-terminal domain Peptidase_S55 PF05580.12 AFZ80463.1 - 0.22 11.4 9.2 5.2 7.0 0.1 4.9 3 1 1 4 4 4 0 SpoIVB peptidase S55 ARID PF01388.21 AFZ80464.1 - 4.2e-05 24.1 0.0 9.8e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain GEN1_C PF18380.1 AFZ80464.1 - 0.095 13.6 0.2 0.18 12.7 0.2 1.3 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain UBX PF00789.20 AFZ80465.1 - 4.7e-15 55.6 0.0 9.2e-15 54.6 0.0 1.4 1 0 0 1 1 1 1 UBX domain Thioredoxin_7 PF13899.6 AFZ80465.1 - 0.031 14.5 0.0 0.081 13.1 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin-like Helicase_C_2 PF13307.6 AFZ80466.1 - 1.2e-41 142.8 0.0 4.3e-41 140.9 0.0 2.0 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 AFZ80466.1 - 7.6e-34 116.8 2.0 3e-30 105.2 0.4 2.7 2 1 0 2 2 2 2 DEAD_2 HBB PF06777.11 AFZ80466.1 - 1.6e-22 80.2 1.6 2.3e-16 60.0 0.3 2.7 2 1 0 2 2 2 2 Helical and beta-bridge domain ResIII PF04851.15 AFZ80466.1 - 1.9e-08 34.5 0.0 0.00015 21.9 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.29 AFZ80466.1 - 0.0035 17.1 0.1 0.19 11.5 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase LXG PF04740.12 AFZ80466.1 - 0.14 11.8 0.1 6.4 6.4 0.0 2.4 1 1 1 2 2 2 0 LXG domain of WXG superfamily ZapB PF06005.12 AFZ80469.1 - 0.0042 17.5 2.9 0.0042 17.5 2.9 5.6 2 1 1 3 3 2 2 Cell division protein ZapB KELK PF15796.5 AFZ80469.1 - 0.021 15.3 3.3 0.021 15.3 3.3 4.3 2 1 2 4 4 4 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase UPF0242 PF06785.11 AFZ80469.1 - 0.14 12.2 44.4 0.4 10.8 2.9 4.5 1 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus bZIP_1 PF00170.21 AFZ80469.1 - 0.25 11.5 33.0 2.4 8.3 0.2 6.4 4 2 2 6 6 6 0 bZIP transcription factor TPR_MLP1_2 PF07926.12 AFZ80469.1 - 0.32 11.1 32.5 1.8 8.7 0.6 4.4 1 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein DUF3450 PF11932.8 AFZ80469.1 - 0.45 9.8 28.8 3.5 6.8 4.0 6.8 5 1 3 9 9 9 0 Protein of unknown function (DUF3450) Filament PF00038.21 AFZ80469.1 - 0.48 10.0 37.5 0.077 12.6 20.5 3.2 1 1 1 2 2 2 0 Intermediate filament protein Jnk-SapK_ap_N PF09744.9 AFZ80469.1 - 0.58 10.4 37.1 22 5.2 7.0 4.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 GAS PF13851.6 AFZ80469.1 - 0.83 9.0 48.1 0.29 10.4 8.3 4.8 2 1 3 6 6 6 0 Growth-arrest specific micro-tubule binding FtsL PF04999.13 AFZ80469.1 - 2.2 8.3 7.3 0.97 9.5 1.3 3.1 1 1 1 2 2 2 0 Cell division protein FtsL DivIC PF04977.15 AFZ80469.1 - 3.2 7.6 30.6 17 5.3 0.4 6.9 2 1 4 6 6 6 0 Septum formation initiator ATG16 PF08614.11 AFZ80469.1 - 4 7.6 35.3 0.34 11.1 25.6 2.6 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) CENP-H PF05837.12 AFZ80469.1 - 4.7 7.7 36.4 2.5 8.5 0.4 5.3 3 2 3 6 6 6 0 Centromere protein H (CENP-H) Cob_adeno_trans PF01923.18 AFZ80469.1 - 5.5 7.1 9.1 5.9 7.0 3.3 3.0 2 1 1 3 3 3 0 Cobalamin adenosyltransferase YabA PF06156.13 AFZ80469.1 - 8.8 7.0 42.6 3.9 8.2 1.2 5.7 2 1 4 6 6 5 0 Initiation control protein YabA GCP_N_terminal PF17681.1 AFZ80470.1 - 7.9e-41 140.7 1.0 7.9e-41 140.7 1.0 1.6 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal DUF5394 PF17372.2 AFZ80470.1 - 0.49 9.9 7.0 0.36 10.3 0.4 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5394) Peptidase_M16 PF00675.20 AFZ80471.1 - 2.6e-44 150.8 0.0 5e-44 149.9 0.0 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 AFZ80471.1 - 1e-31 110.4 0.0 5.6e-30 104.7 0.0 2.5 2 0 0 2 2 2 2 Peptidase M16 inactive domain Sas10_Utp3 PF04000.15 AFZ80472.1 - 0.084 13.5 0.1 0.18 12.4 0.0 1.5 2 0 0 2 2 2 0 Sas10/Utp3/C1D family NYD-SP28 PF14772.6 AFZ80473.1 - 0.012 15.6 2.5 0.015 15.4 2.5 1.2 1 0 0 1 1 1 0 Sperm tail Polysacc_synt_2 PF02719.15 AFZ80474.1 - 0.095 11.8 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein CaKB PF03185.15 AFZ80475.1 - 0.077 12.7 0.4 0.13 11.9 0.4 1.4 1 0 0 1 1 1 0 Calcium-activated potassium channel, beta subunit Pkinase PF00069.25 AFZ80476.1 - 3.2e-42 144.7 0.0 4.3e-42 144.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ80476.1 - 1.1e-19 70.7 0.0 1.7e-19 70.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FSH1 PF03959.13 AFZ80477.1 - 9.6e-42 143.0 0.0 1.5e-41 142.4 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DAP3 PF10236.9 AFZ80477.1 - 1.2e-27 96.9 0.0 9.4e-27 94.0 0.0 2.0 1 1 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 Abhydrolase_2 PF02230.16 AFZ80477.1 - 0.00044 20.1 0.0 0.0035 17.2 0.0 2.1 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase AAA_16 PF13191.6 AFZ80477.1 - 0.00046 20.6 0.0 0.0059 17.0 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 AFZ80477.1 - 0.19 11.4 0.0 0.39 10.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 AFZ80478.1 - 2.8e-35 121.7 0.2 7.2e-35 120.3 0.2 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AFZ80478.1 - 6.5e-24 84.4 3.1 1.6e-23 83.1 1.3 2.6 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AFZ80478.1 - 6.8e-10 39.2 1.7 1.8e-09 37.9 0.0 2.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit tRNA-synt_His PF13393.6 AFZ80479.1 - 1e-42 146.5 0.0 1.9e-42 145.6 0.0 1.5 1 0 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 AFZ80479.1 - 2.4e-10 40.4 0.2 4.9e-10 39.4 0.2 1.6 1 0 0 1 1 1 1 Anticodon binding domain HGTP_anticodon2 PF12745.7 AFZ80479.1 - 0.0014 18.2 0.2 0.0024 17.4 0.2 1.3 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs tRNA-synt_2 PF00152.20 AFZ80479.1 - 0.021 13.9 0.3 0.06 12.4 0.0 1.9 2 0 0 2 2 2 0 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 AFZ80479.1 - 0.032 13.7 0.1 0.1 12.1 0.0 1.9 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) DUF4902 PF16245.5 AFZ80479.1 - 0.051 13.5 0.0 0.33 10.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4902) Forkhead PF00250.18 AFZ80480.1 - 0.69 10.2 6.9 1.1 9.5 3.0 2.8 3 0 0 3 3 3 0 Forkhead domain WD40 PF00400.32 AFZ80482.1 - 9.5e-13 48.4 0.8 0.12 13.3 0.0 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat CAF1C_H4-bd PF12265.8 AFZ80482.1 - 8.1e-11 42.0 0.1 2.3e-10 40.6 0.1 1.9 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex ANAPC4_WD40 PF12894.7 AFZ80482.1 - 0.00058 20.1 0.0 0.66 10.3 0.0 3.6 1 1 3 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 AFZ80482.1 - 0.0012 18.3 0.2 0.002 17.5 0.2 1.4 1 0 0 1 1 1 1 WD40-like domain WD40 PF00400.32 AFZ80483.1 - 1.3e-10 41.7 12.5 0.0095 16.8 0.3 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat WD40_like PF17005.5 AFZ80483.1 - 0.0088 15.4 0.0 3.9 6.7 0.0 2.2 2 0 0 2 2 2 2 WD40-like domain SpoU_methylase PF00588.19 AFZ80484.1 - 1.9e-21 76.7 0.0 3.3e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 SpoU rRNA Methylase family CagY_I PF14585.6 AFZ80484.1 - 0.19 11.9 0.1 0.36 10.9 0.1 1.4 1 0 0 1 1 1 0 CagY type 1 repeat IMCp PF12314.8 AFZ80486.1 - 7.2e-18 64.7 54.0 1.8e-12 47.4 24.0 2.2 1 1 1 2 2 2 2 Inner membrane complex protein ArfGap PF01412.18 AFZ80488.1 - 3.8e-38 130.2 0.0 6.8e-38 129.3 0.0 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PG_binding_4 PF12229.8 AFZ80488.1 - 0.062 13.6 0.1 0.093 13.0 0.1 1.3 1 0 0 1 1 1 0 Putative peptidoglycan binding domain NADH_dh_m_C1 PF15088.6 AFZ80488.1 - 0.19 11.4 0.0 0.41 10.3 0.0 1.5 1 0 0 1 1 1 0 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial Shisa PF13908.6 AFZ80490.1 - 0.0095 16.2 0.5 0.36 11.0 0.0 2.7 2 0 0 2 2 2 2 Wnt and FGF inhibitory regulator DUF760 PF05542.11 AFZ80491.1 - 3.9e-28 97.6 0.0 2.8e-13 50.0 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF760) DUF1467 PF07330.12 AFZ80491.1 - 0.1 12.5 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1467) DUF4984 PF16372.5 AFZ80491.1 - 0.12 12.3 0.1 0.19 11.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4984) Suf PF05843.14 AFZ80492.1 - 6.5e-07 29.6 1.4 6.5e-07 29.6 1.4 3.6 4 1 0 4 4 4 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 AFZ80492.1 - 0.048 14.5 0.1 1.2 10.2 0.0 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat Thioredoxin PF00085.20 AFZ80493.1 - 5.9e-17 61.5 0.0 9.6e-16 57.6 0.0 2.7 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_6 PF13848.6 AFZ80493.1 - 9.7e-15 55.0 3.2 8.7e-05 22.5 2.3 3.8 2 1 1 3 3 3 3 Thioredoxin-like domain Glutaredoxin PF00462.24 AFZ80493.1 - 0.0045 17.2 0.0 0.63 10.3 0.0 2.7 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin_2 PF13098.6 AFZ80493.1 - 0.034 14.6 0.1 0.14 12.6 0.0 2.2 1 1 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_7 PF13899.6 AFZ80493.1 - 0.061 13.5 0.0 0.2 11.9 0.0 1.9 1 0 0 1 1 1 0 Thioredoxin-like Myb_DNA-binding PF00249.31 AFZ80494.1 - 6.8e-11 42.2 0.0 1.5e-10 41.1 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AFZ80494.1 - 6.7e-06 26.3 0.0 2.6e-05 24.4 0.0 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain ZZ PF00569.17 AFZ80494.1 - 0.00041 20.1 12.8 0.00041 20.1 12.8 1.7 2 0 0 2 2 2 1 Zinc finger, ZZ type ThiF PF00899.21 AFZ80495.1 - 2.4e-60 204.0 0.3 4.4e-60 203.1 0.1 1.5 2 0 0 2 2 2 1 ThiF family UAE_UbL PF14732.6 AFZ80495.1 - 2.2e-09 37.8 0.5 6e-09 36.4 0.5 1.8 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 AFZ80495.1 - 2.2e-08 34.3 0.4 8.5e-05 22.6 0.2 2.7 1 1 1 2 2 2 2 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.20 AFZ80495.1 - 2.9e-05 24.1 2.2 3.4e-05 23.9 0.0 2.2 3 0 0 3 3 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 AFZ80495.1 - 0.00015 22.1 0.0 0.00047 20.5 0.0 1.8 1 0 0 1 1 1 1 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 AFZ80495.1 - 0.0006 20.1 0.3 0.0017 18.6 0.3 1.8 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Pyr_redox PF00070.27 AFZ80495.1 - 0.0044 17.5 0.1 0.014 15.9 0.1 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase MIEAP PF16026.5 AFZ80495.1 - 0.022 15.0 0.4 0.045 14.0 0.4 1.5 1 0 0 1 1 1 0 Mitochondria-eating protein TrkA_N PF02254.18 AFZ80495.1 - 0.026 14.8 0.3 0.072 13.4 0.1 1.9 2 0 0 2 2 2 0 TrkA-N domain Pyr_redox_2 PF07992.14 AFZ80495.1 - 0.042 13.1 0.0 0.13 11.5 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 AFZ80495.1 - 0.053 13.2 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA KR PF08659.10 AFZ80495.1 - 0.088 12.7 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 KR domain PglD_N PF17836.1 AFZ80495.1 - 0.15 12.7 0.6 0.54 10.9 0.2 2.2 2 0 0 2 2 1 0 PglD N-terminal domain RNA_pol_A_bac PF01000.26 AFZ80496.1 - 1.5e-10 41.5 0.0 8.1e-10 39.1 0.0 2.2 3 0 0 3 3 3 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 AFZ80496.1 - 0.00037 19.9 0.0 0.00071 19.0 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_A_CTD PF03118.15 AFZ80496.1 - 0.17 11.6 0.4 2.3 8.0 0.0 2.5 2 0 0 2 2 2 0 Bacterial RNA polymerase, alpha chain C terminal domain Wyosine_form PF08608.12 AFZ80497.1 - 1.8e-26 92.3 0.0 3.4e-26 91.4 0.0 1.5 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.21 AFZ80497.1 - 3.7e-22 79.5 0.1 7.9e-22 78.4 0.1 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Spb1_C PF07780.12 AFZ80497.1 - 0.11 12.2 1.2 0.17 11.5 1.2 1.2 1 0 0 1 1 1 0 Spb1 C-terminal domain AAA_23 PF13476.6 AFZ80499.1 - 5.8e-14 53.1 11.2 5.8e-14 53.1 11.2 5.5 2 2 1 3 3 1 1 AAA domain SMC_N PF02463.19 AFZ80499.1 - 2.7e-12 46.6 40.4 1.7e-11 44.0 40.4 2.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain APG6_N PF17675.1 AFZ80499.1 - 0.00045 20.8 11.6 0.00045 20.8 11.6 6.3 3 2 2 6 6 6 1 Apg6 coiled-coil region MscS_porin PF12795.7 AFZ80499.1 - 0.0077 15.8 12.5 0.0077 15.8 12.5 5.9 4 2 2 6 6 6 2 Mechanosensitive ion channel porin domain AAA_29 PF13555.6 AFZ80499.1 - 0.041 13.6 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain SbcCD_C PF13558.6 AFZ80499.1 - 0.078 13.2 0.0 0.2 11.9 0.0 1.7 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DUF2756 PF10956.8 AFZ80499.1 - 0.16 12.5 2.0 1.2 9.6 2.0 2.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2756) Matrilin_ccoil PF10393.9 AFZ80499.1 - 0.69 9.8 7.6 7.1 6.6 0.3 4.2 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin MLD PF11647.8 AFZ80499.1 - 0.83 10.0 6.0 5.8 7.3 1.1 4.0 2 0 0 2 2 2 0 Membrane Localization Domain TPR_MLP1_2 PF07926.12 AFZ80499.1 - 2.4 8.2 75.4 0.12 12.4 8.8 7.4 4 2 0 6 6 6 0 TPR/MLP1/MLP2-like protein PI3K_P85_iSH2 PF16454.5 AFZ80499.1 - 2.8 7.5 76.6 0.026 14.1 1.7 5.7 3 2 1 5 5 5 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain AMP-binding PF00501.28 AFZ80500.1 - 7.4e-69 232.4 0.0 9.7e-69 232.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 AFZ80500.1 - 6.2e-06 27.1 0.0 1.2e-05 26.2 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Glycos_transf_4 PF00953.21 AFZ80501.1 - 2.8e-34 118.4 16.0 2.8e-34 118.4 16.0 2.3 2 0 0 2 2 2 1 Glycosyl transferase family 4 DUF962 PF06127.11 AFZ80501.1 - 0.37 10.9 4.2 0.48 10.5 1.5 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF962) Lactamase_B_2 PF12706.7 AFZ80502.1 - 7.1e-08 32.2 0.0 5.1e-06 26.1 0.0 2.3 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 AFZ80502.1 - 5.4e-05 23.3 0.0 0.0001 22.4 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily TAP42 PF04177.12 AFZ80503.1 - 2.8e-41 141.7 2.7 3.4e-41 141.4 2.7 1.1 1 0 0 1 1 1 1 TAP42-like family NAC PF01849.18 AFZ80503.1 - 0.2 11.7 0.5 0.79 9.7 0.0 2.1 2 0 0 2 2 2 0 NAC domain Rotamase PF00639.21 AFZ80505.1 - 1.7e-21 77.0 0.0 2e-21 76.7 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 AFZ80505.1 - 6.1e-19 68.7 0.0 7.1e-19 68.5 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 AFZ80505.1 - 2.6e-05 25.0 0.0 3.3e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Methyltransf_5 PF01795.19 AFZ80506.1 - 1.6e-85 287.4 0.2 1.1e-84 284.6 0.2 1.9 1 1 0 1 1 1 1 MraW methylase family Methyltransf_31 PF13847.6 AFZ80506.1 - 0.00024 20.9 0.0 0.72 9.6 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 AFZ80506.1 - 0.0062 17.2 0.0 0.016 15.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AFZ80506.1 - 0.0062 16.1 0.0 3.4 7.2 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase small domain Methyltransf_15 PF09445.10 AFZ80506.1 - 0.043 13.4 0.0 0.085 12.4 0.0 1.5 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_12 PF08242.12 AFZ80506.1 - 0.11 13.3 0.0 0.74 10.6 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain PAC4 PF16093.5 AFZ80507.1 - 8.5e-13 48.3 0.0 1.1e-12 47.9 0.0 1.1 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 RTTN_N PF14726.6 AFZ80508.1 - 0.091 13.6 0.2 0.32 11.8 0.2 1.9 1 0 0 1 1 1 0 Rotatin, an armadillo repeat protein, centriole functioning DUF5344 PF17279.2 AFZ80508.1 - 0.94 10.1 12.4 1.8 9.2 2.3 3.3 2 0 0 2 2 2 0 Family of unknown function (DUF5344) SPOC PF07744.13 AFZ80509.1 - 3e-09 37.0 0.0 7.6e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 SPOC domain RRM_1 PF00076.22 AFZ80509.1 - 1.4e-07 31.3 0.0 0.00023 20.9 0.0 3.7 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AFZ80509.1 - 0.035 13.9 0.0 0.13 12.1 0.1 1.9 2 0 0 2 2 2 0 Occluded RNA-recognition motif ISP1_C PF18161.1 AFZ80510.1 - 1.1e-43 147.6 1.0 1.3e-43 147.3 1.0 1.1 1 0 0 1 1 1 1 ISP1 C-terminal ISP3_C PF18045.1 AFZ80510.1 - 1.5e-36 124.6 0.7 1.8e-36 124.4 0.7 1.1 1 0 0 1 1 1 1 ISP3 C-terminal Met_asp_mut_E PF06368.11 AFZ80510.1 - 0.011 14.3 0.0 0.012 14.1 0.0 1.0 1 0 0 1 1 1 0 Methylaspartate mutase E chain (MutE) Ribosomal_L22 PF00237.19 AFZ80511.1 - 6.6e-09 35.9 0.0 1.1e-08 35.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e MgtE_N PF03448.17 AFZ80511.1 - 0.022 15.3 0.0 0.053 14.1 0.0 1.6 1 0 0 1 1 1 0 MgtE intracellular N domain Spo7_2_N PF15407.6 AFZ80511.1 - 0.1 12.2 2.4 0.28 10.9 0.0 2.6 3 0 0 3 3 3 0 Sporulation protein family 7 Kin17_mid PF10357.9 AFZ80512.1 - 1.3e-43 147.9 2.6 3.1e-43 146.7 2.6 1.6 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein KN17_SH3 PF18131.1 AFZ80512.1 - 0.00012 22.1 0.6 0.00041 20.4 0.4 1.9 2 0 0 2 2 2 1 KN17 SH3-like C-terminal domain zf-met PF12874.7 AFZ80512.1 - 0.01 16.2 3.4 0.032 14.6 3.4 1.9 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 AFZ80512.1 - 0.015 15.5 5.0 0.05 13.9 5.0 2.0 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding DUF2540 PF10802.8 AFZ80512.1 - 1.7 8.8 6.5 0.19 11.8 0.6 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2540) PspB PF06667.12 AFZ80512.1 - 3.3 7.8 4.6 33 4.6 0.1 2.7 3 0 0 3 3 3 0 Phage shock protein B Synaptobrevin PF00957.21 AFZ80514.1 - 2.8e-05 23.8 0.2 3e-05 23.7 0.2 1.1 1 0 0 1 1 1 1 Synaptobrevin CtaG_Cox11 PF04442.14 AFZ80515.1 - 4.2e-50 169.7 0.1 5.9e-50 169.2 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 O-ag_pol_Wzy PF14296.6 AFZ80515.1 - 0.0046 15.7 0.4 0.0069 15.1 0.4 1.2 1 0 0 1 1 1 1 O-antigen polysaccharide polymerase Wzy DUF3786 PF12654.7 AFZ80515.1 - 0.06 12.9 0.0 0.16 11.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3786) HA2 PF04408.23 AFZ80516.1 - 1.7e-08 34.7 0.0 3.1e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 AFZ80516.1 - 1.2e-07 31.9 0.0 3.3e-07 30.6 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Prefoldin PF02996.17 AFZ80517.1 - 9.2e-23 80.4 1.1 1.3e-22 79.9 1.1 1.3 1 0 0 1 1 1 1 Prefoldin subunit DUF4600 PF15372.6 AFZ80517.1 - 0.002 18.5 1.8 0.13 12.7 0.2 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4600) SWC7 PF17330.2 AFZ80517.1 - 0.036 14.1 0.1 0.39 10.8 0.0 2.3 2 0 0 2 2 2 0 SWR1 chromatin-remodelling complex, sub-unit Swc7 SlyX PF04102.12 AFZ80517.1 - 0.27 11.9 4.5 4.1 8.1 1.4 2.2 2 0 0 2 2 2 0 SlyX TolA_bind_tri PF16331.5 AFZ80517.1 - 0.6 10.2 5.5 0.5 10.5 1.3 2.4 2 1 0 2 2 2 0 TolA binding protein trimerisation Cep57_MT_bd PF06657.13 AFZ80517.1 - 1.8 9.1 6.0 18 5.9 0.2 2.6 2 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Glycolytic PF00274.19 AFZ80518.1 - 1.4e-161 537.1 0.0 1.6e-161 536.9 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I PRMT5 PF05185.16 AFZ80519.1 - 4.3e-55 186.2 0.0 7.4e-55 185.5 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 AFZ80519.1 - 4.1e-49 166.9 1.7 6.5e-49 166.2 1.7 1.3 1 0 0 1 1 1 1 PRMT5 oligomerisation domain PRMT5_TIM PF17285.2 AFZ80519.1 - 9.1e-31 107.0 0.1 1.5e-30 106.3 0.1 1.2 1 0 0 1 1 1 1 PRMT5 TIM barrel domain Met_10 PF02475.16 AFZ80519.1 - 0.0063 16.3 0.0 0.017 14.9 0.0 1.7 2 0 0 2 2 2 1 Met-10+ like-protein V_cholerae_RfbT PF05575.11 AFZ80519.1 - 0.066 12.5 0.1 0.18 11.1 0.0 1.6 2 0 0 2 2 2 0 Vibrio cholerae RfbT protein Sec23_trunk PF04811.15 AFZ80520.1 - 2.9e-44 151.5 0.0 6e-44 150.4 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 AFZ80520.1 - 2.9e-19 69.6 0.0 9.1e-19 68.0 0.0 1.9 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 AFZ80520.1 - 1.3e-14 53.9 5.4 3e-14 52.8 5.4 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_helical PF04815.15 AFZ80520.1 - 8.1e-14 51.3 0.0 2e-13 50.1 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Gelsolin PF00626.22 AFZ80520.1 - 1.6e-07 31.1 0.0 3.8e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat VWA_2 PF13519.6 AFZ80520.1 - 0.0037 17.9 0.1 0.097 13.3 0.1 2.5 1 1 0 2 2 2 1 von Willebrand factor type A domain Vps36-NZF-N PF16988.5 AFZ80520.1 - 0.0064 15.9 0.1 0.024 14.0 0.1 2.0 1 0 0 1 1 1 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain VWA PF00092.28 AFZ80520.1 - 0.017 15.4 0.0 0.18 12.0 0.1 2.3 2 0 0 2 2 2 0 von Willebrand factor type A domain Use1 PF09753.9 AFZ80523.1 - 7.9e-06 25.8 7.7 1.9e-05 24.5 7.4 1.6 1 1 1 2 2 2 1 Membrane fusion protein Use1 DUF2102 PF09875.9 AFZ80523.1 - 0.081 12.6 0.0 0.28 10.9 0.0 1.9 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2102) HU-CCDC81_bac_2 PF18175.1 AFZ80523.1 - 0.14 12.0 0.8 6 6.8 0.0 3.0 2 1 1 3 3 3 0 CCDC81-like prokaryotic HU domain 2 Orf78 PF06024.12 AFZ80523.1 - 1.3 9.4 4.5 0.46 10.8 0.9 2.0 1 1 1 2 2 2 0 Orf78 (ac78) Hydrolase_4 PF12146.8 AFZ80525.1 - 7.7e-22 77.7 0.0 3.6e-21 75.5 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FAINT PF04385.15 AFZ80525.1 - 6e-13 48.7 5.9 0.0037 17.3 0.0 5.2 4 0 0 4 4 4 4 Domain of unknown function, DUF529 Abhydrolase_1 PF00561.20 AFZ80525.1 - 0.00026 20.7 0.1 0.0033 17.1 0.1 2.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AFZ80525.1 - 0.00046 20.9 0.0 0.0012 19.5 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF900 PF05990.12 AFZ80525.1 - 0.012 15.1 0.0 0.022 14.2 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) LCAT PF02450.15 AFZ80525.1 - 0.028 13.6 0.3 0.067 12.3 0.0 1.7 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase PGAP1 PF07819.13 AFZ80525.1 - 0.094 12.4 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 PGAP1-like protein DUF676 PF05057.14 AFZ80525.1 - 0.12 11.8 0.0 1.2 8.6 0.0 2.2 2 0 0 2 2 2 0 Putative serine esterase (DUF676) Hydrolase_3 PF08282.12 AFZ80526.1 - 1e-38 133.6 0.0 1.6e-38 132.9 0.0 1.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AFZ80526.1 - 0.0008 19.7 0.0 0.0047 17.2 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 AFZ80526.1 - 0.0012 18.5 0.0 0.024 14.1 0.0 2.2 2 0 0 2 2 2 1 Sucrose-6F-phosphate phosphohydrolase Baculo_LEF-2 PF03041.14 AFZ80526.1 - 0.058 13.0 0.1 0.13 11.9 0.1 1.6 1 0 0 1 1 1 0 lef-2 HAD PF12710.7 AFZ80526.1 - 0.11 12.9 0.4 16 5.9 0.0 2.7 2 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase Fe-S_assembly PF04384.13 AFZ80527.1 - 1.7e-18 67.0 0.1 2.7e-18 66.3 0.1 1.3 1 0 0 1 1 1 1 Iron-sulphur cluster assembly COX2 PF00116.20 AFZ80528.1 - 0.0035 17.2 0.2 0.0081 16.0 0.2 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, periplasmic domain TFCD_C PF12612.8 AFZ80529.1 - 0.023 14.5 6.3 4.5 7.1 0.2 4.9 3 1 1 4 4 4 0 Tubulin folding cofactor D C terminal MitMem_reg PF13012.6 AFZ80529.1 - 0.063 13.7 1.5 1.6 9.2 0.0 3.7 3 0 0 3 3 3 0 Maintenance of mitochondrial structure and function DSHCT PF08148.12 AFZ80529.1 - 0.1 12.3 0.0 16 5.1 0.0 2.9 2 0 0 2 2 2 0 DSHCT (NUC185) domain DUF5105 PF17118.5 AFZ80529.1 - 0.12 12.1 0.4 0.29 10.9 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5105) Arm PF00514.23 AFZ80529.1 - 2.5 8.3 19.5 6.5 6.9 0.0 8.5 9 0 0 9 9 9 0 Armadillo/beta-catenin-like repeat PNK3P PF08645.11 AFZ80530.1 - 1.4e-46 158.2 0.0 2.2e-46 157.5 0.0 1.3 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 AFZ80530.1 - 4.9e-07 30.0 0.0 0.041 14.0 0.0 2.4 1 1 1 2 2 2 2 AAA domain KTI12 PF08433.10 AFZ80530.1 - 0.00039 19.9 0.0 0.63 9.4 0.0 2.2 2 0 0 2 2 2 2 Chromatin associated protein KTI12 AAA_24 PF13479.6 AFZ80530.1 - 0.02 14.6 0.0 0.059 13.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 AFZ80530.1 - 0.069 13.4 0.0 0.24 11.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain HAD_2 PF13419.6 AFZ80530.1 - 0.077 13.1 0.0 17 5.4 0.0 2.6 2 1 1 3 3 3 0 Haloacid dehalogenase-like hydrolase Zeta_toxin PF06414.12 AFZ80530.1 - 0.11 11.7 0.0 6.4 6.0 0.0 2.3 1 1 1 2 2 2 0 Zeta toxin Hydrolase_like PF13242.6 AFZ80530.1 - 0.12 12.5 0.0 5.2 7.2 0.0 2.6 2 0 0 2 2 2 0 HAD-hyrolase-like Terpene_synth_C PF03936.16 AFZ80531.1 - 0.0013 18.1 1.4 0.0025 17.2 1.4 1.5 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain COG5 PF10392.9 AFZ80531.1 - 0.008 16.3 6.0 0.013 15.7 1.2 3.1 3 0 0 3 3 3 1 Golgi transport complex subunit 5 Vps39_1 PF10366.9 AFZ80531.1 - 0.057 13.7 0.3 0.21 11.9 0.3 2.0 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 1 TPR_14 PF13428.6 AFZ80532.1 - 2.3e-09 37.3 5.6 2.4 9.2 0.0 8.2 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_8 PF13181.6 AFZ80532.1 - 1.5e-06 28.0 13.0 0.011 15.9 0.0 6.8 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_2 PF07719.17 AFZ80532.1 - 4.4e-05 23.3 15.0 0.2 11.8 0.0 7.3 8 0 0 8 8 7 2 Tetratricopeptide repeat RPN7 PF10602.9 AFZ80532.1 - 0.00015 21.6 0.2 0.0054 16.4 0.1 2.9 2 0 0 2 2 2 1 26S proteasome subunit RPN7 TPR_12 PF13424.6 AFZ80532.1 - 0.00016 21.9 6.3 1.9 8.8 0.1 5.4 6 1 0 6 6 5 2 Tetratricopeptide repeat TPR_MalT PF17874.1 AFZ80532.1 - 0.0028 17.1 0.2 0.13 11.6 0.0 2.7 3 0 0 3 3 3 1 MalT-like TPR region NRDE-2 PF08424.10 AFZ80532.1 - 0.017 14.2 5.2 0.86 8.7 0.0 4.2 3 1 2 5 5 5 0 NRDE-2, necessary for RNA interference TPR_11 PF13414.6 AFZ80532.1 - 0.028 14.1 5.0 5 6.9 0.3 4.3 4 0 0 4 4 4 0 TPR repeat SNAP PF14938.6 AFZ80532.1 - 0.037 13.4 0.2 0.35 10.2 0.2 2.5 1 1 1 2 2 2 0 Soluble NSF attachment protein, SNAP TPR_17 PF13431.6 AFZ80532.1 - 0.14 12.6 0.7 29 5.4 0.0 4.8 4 0 0 4 4 3 0 Tetratricopeptide repeat Suf PF05843.14 AFZ80532.1 - 0.21 11.6 12.7 0.95 9.4 2.9 3.9 3 1 1 4 4 4 0 Suppressor of forked protein (Suf) TPR_7 PF13176.6 AFZ80532.1 - 0.7 10.1 2.4 12 6.2 0.1 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat IFT20 PF14931.6 AFZ80532.1 - 0.8 9.9 3.1 3.3 7.9 0.2 3.0 3 0 0 3 3 3 0 Intraflagellar transport complex B, subunit 20 HAT PF02184.16 AFZ80532.1 - 1.1 9.3 14.7 10 6.2 1.3 5.6 5 0 0 5 5 5 0 HAT (Half-A-TPR) repeat Mad3_BUB1_I PF08311.12 AFZ80532.1 - 4.7 7.2 20.2 0.075 13.0 0.9 6.2 4 3 3 7 7 7 0 Mad3/BUB1 homology region 1 TPR_1 PF00515.28 AFZ80532.1 - 5.4 7.0 12.6 17 5.5 0.0 5.4 7 0 0 7 7 7 0 Tetratricopeptide repeat RRM_1 PF00076.22 AFZ80533.1 - 4.5e-16 58.4 0.0 6.5e-11 41.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WW PF00397.26 AFZ80533.1 - 4.8e-09 36.2 4.2 1.1e-08 35.0 4.2 1.6 1 0 0 1 1 1 1 WW domain DUF4542 PF15075.6 AFZ80533.1 - 0.052 13.9 0.0 0.086 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4542) V-SNARE_C PF12352.8 AFZ80534.1 - 1.8e-06 28.1 2.1 9.7e-06 25.8 0.2 2.5 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 AFZ80534.1 - 0.0015 18.4 2.7 0.0022 17.8 0.2 2.2 2 1 0 2 2 2 1 Sec20 V-SNARE PF05008.15 AFZ80534.1 - 0.018 15.4 7.8 0.13 12.6 4.9 2.9 2 1 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus Pex24p PF06398.11 AFZ80534.1 - 0.023 13.7 0.5 0.052 12.5 0.3 1.4 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin DUF4144 PF13642.6 AFZ80534.1 - 0.024 15.2 0.7 0.049 14.2 0.2 1.8 2 0 0 2 2 2 0 protein structure with unknown function DUF2935 PF11155.8 AFZ80534.1 - 0.13 12.6 2.6 0.21 11.9 0.8 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) DUF745 PF05335.13 AFZ80534.1 - 0.3 10.8 4.4 1.1 8.9 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) DUF883 PF05957.13 AFZ80534.1 - 1 10.0 4.2 3 8.5 1.7 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) B56 PF01603.20 AFZ80535.1 - 9.3e-147 489.3 16.8 1.2e-146 488.9 16.8 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) IMP2_N PF18590.1 AFZ80536.1 - 3.8e-24 85.0 0.2 5.9e-24 84.4 0.2 1.3 1 0 0 1 1 1 1 Immune Mapped Protein 2 (IMP2) N-terminal domain IMP2_C PF18591.1 AFZ80536.1 - 0.019 14.8 0.0 0.039 13.8 0.0 1.6 1 0 0 1 1 1 0 Immune Mapped Protein 2 (IMP2) C-terminal domain TP53IP5 PF15331.6 AFZ80536.1 - 0.31 11.1 4.4 0.48 10.5 4.4 1.2 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 FidL_like PF15941.5 AFZ80537.1 - 0.67 10.4 4.1 0.62 10.6 1.7 2.0 2 0 0 2 2 2 0 FidL-like putative membrane protein RRN3 PF05327.11 AFZ80537.1 - 3.3 6.1 11.4 4.1 5.8 11.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 LMBR1 PF04791.16 AFZ80537.1 - 4.6 6.0 5.6 4.8 6.0 5.6 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Chal_sti_synt_N PF00195.19 AFZ80538.1 - 0.046 13.1 0.1 0.12 11.7 0.0 1.6 2 0 0 2 2 2 0 Chalcone and stilbene synthases, N-terminal domain HECT PF00632.25 AFZ80540.1 - 1e-63 215.7 0.3 2.8e-63 214.3 0.3 1.7 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF1160 PF06648.11 AFZ80540.1 - 1.9 8.5 5.0 0.69 9.9 1.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1160) Methyltr_RsmB-F PF01189.17 AFZ80541.1 - 4.9e-35 121.0 0.0 6.4e-34 117.4 0.0 2.6 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 AFZ80541.1 - 0.017 15.2 0.0 0.035 14.2 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase VitD-bind_III PF09164.10 AFZ80541.1 - 0.095 12.7 0.1 0.2 11.6 0.1 1.5 1 0 0 1 1 1 0 Vitamin D binding protein, domain III SAM_2 PF07647.17 AFZ80542.1 - 0.00053 20.0 0.0 0.1 12.8 0.0 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 AFZ80542.1 - 0.014 15.9 0.0 0.34 11.4 0.0 2.8 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) IpaB_EvcA PF03278.13 AFZ80543.1 - 0.00062 19.5 0.7 0.0024 17.6 0.7 2.0 1 0 0 1 1 1 1 IpaB/EvcA family Pribosyltran PF00156.27 AFZ80544.1 - 1.3e-11 44.3 0.1 2.1e-11 43.6 0.1 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain S-AdoMet_synt_N PF00438.20 AFZ80544.1 - 0.15 12.7 0.1 0.82 10.4 0.0 2.2 2 1 0 2 2 2 0 S-adenosylmethionine synthetase, N-terminal domain HEAT PF02985.22 AFZ80545.1 - 1.1e-10 40.8 1.1 0.00035 20.6 0.0 6.3 6 0 0 6 6 6 2 HEAT repeat IBN_N PF03810.19 AFZ80545.1 - 2.2e-09 37.1 0.7 1.5e-08 34.4 0.2 2.8 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT_EZ PF13513.6 AFZ80545.1 - 3.4e-09 37.0 0.9 3.1e-07 30.8 0.0 4.6 6 0 0 6 6 6 1 HEAT-like repeat Cnd1 PF12717.7 AFZ80545.1 - 6.3e-05 23.1 4.1 0.002 18.2 0.0 4.4 3 2 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 AFZ80545.1 - 6.4e-05 23.3 0.0 0.88 10.0 0.0 4.8 4 1 1 5 5 5 1 HEAT repeats Xpo1 PF08389.12 AFZ80545.1 - 0.00016 21.7 10.7 0.0075 16.3 2.8 4.0 3 1 1 4 4 4 1 Exportin 1-like protein DUF1981 PF09324.10 AFZ80545.1 - 0.0028 17.5 0.1 8.1 6.4 0.0 4.0 4 0 0 4 4 4 1 Domain of unknown function (DUF1981) DUF577 PF04510.12 AFZ80545.1 - 0.0054 16.7 0.4 0.75 9.7 0.0 3.7 3 1 0 3 3 3 1 Family of unknown function (DUF577) Arm PF00514.23 AFZ80545.1 - 0.019 15.0 2.2 0.26 11.4 0.0 4.0 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat DCB PF16213.5 AFZ80545.1 - 0.16 11.6 7.2 0.074 12.7 3.7 2.2 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 JmjC PF02373.22 AFZ80547.1 - 2.1e-37 128.0 0.2 4.8e-37 126.9 0.2 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.17 AFZ80547.1 - 2.4e-05 24.2 0.2 5.2e-05 23.1 0.2 1.6 1 0 0 1 1 1 1 jmjN domain zf-C5HC2 PF02928.16 AFZ80547.1 - 5.1e-05 23.6 10.4 0.00016 22.0 10.4 1.9 1 0 0 1 1 1 1 C5HC2 zinc finger EMA PF02488.15 AFZ80548.1 - 2.2e-15 57.0 1.1 2.5e-15 56.8 1.1 1.0 1 0 0 1 1 1 1 Merozoite Antigen Brix PF04427.18 AFZ80549.1 - 2.9e-33 115.6 0.2 3.8e-33 115.2 0.2 1.2 1 0 0 1 1 1 1 Brix domain Exo5 PF09810.9 AFZ80550.1 - 1.2e-57 196.1 15.9 2.5e-32 112.8 4.5 3.0 1 1 2 3 3 3 3 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.7 AFZ80550.1 - 1.8e-06 28.1 1.0 2.7e-06 27.5 1.0 1.3 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily DUF4522 PF15022.6 AFZ80550.1 - 0.17 12.2 1.5 0.65 10.3 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4522) MRNIP PF15749.5 AFZ80550.1 - 0.4 11.4 4.2 0.17 12.7 0.9 2.0 2 0 0 2 2 2 0 MRN-interacting protein RNase_HII PF01351.18 AFZ80551.1 - 5e-48 163.6 0.0 7.1e-48 163.1 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease HII AKAP7_NLS PF10469.9 AFZ80552.1 - 9.8e-08 32.1 1.0 5.1e-07 29.8 1.0 2.1 1 1 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain Fusion_gly PF00523.18 AFZ80552.1 - 0.0016 16.8 0.7 0.012 13.9 0.0 2.1 2 0 0 2 2 2 1 Fusion glycoprotein F0 Corona_NS2A PF05213.12 AFZ80552.1 - 0.028 13.8 0.0 0.054 12.8 0.0 1.4 1 0 0 1 1 1 0 Coronavirus NS2A protein LigT_PEase PF02834.16 AFZ80552.1 - 0.058 13.6 0.0 0.9 9.8 0.0 2.6 2 0 0 2 2 2 0 LigT like Phosphoesterase DUF4756 PF15948.5 AFZ80552.1 - 0.15 11.9 0.1 0.69 9.7 0.0 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4756) DUF3883 PF13020.6 AFZ80553.1 - 5.8e-20 71.1 1.2 1.3e-19 70.1 1.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3883) SWIM PF04434.17 AFZ80553.1 - 0.00086 18.9 0.4 0.0023 17.6 0.4 1.7 1 0 0 1 1 1 1 SWIM zinc finger Hexokinase_1 PF00349.21 AFZ80554.1 - 4.8e-53 180.0 0.0 6.3e-53 179.6 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 AFZ80554.1 - 3.3e-49 167.5 0.0 4.3e-49 167.1 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Kelch_4 PF13418.6 AFZ80558.1 - 1.6e-42 143.2 18.4 9.6e-11 41.5 0.0 6.8 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_3 PF13415.6 AFZ80558.1 - 5.2e-28 96.7 10.9 3.9e-05 23.8 0.1 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 AFZ80558.1 - 4.7e-27 93.5 11.8 1.8e-05 24.6 0.0 6.0 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 AFZ80558.1 - 9.2e-25 86.0 7.4 4.1e-05 23.1 0.1 5.7 5 0 0 5 5 5 5 Kelch motif Kelch_6 PF13964.6 AFZ80558.1 - 2.2e-20 72.2 16.1 0.0013 18.9 0.3 6.5 4 2 2 6 6 6 5 Kelch motif Kelch_2 PF07646.15 AFZ80558.1 - 9.7e-15 53.9 12.7 0.0002 21.2 0.3 6.3 6 1 0 6 6 6 3 Kelch motif EGF_2 PF07974.13 AFZ80558.1 - 0.0056 17.0 14.0 0.019 15.3 14.0 2.0 1 0 0 1 1 1 1 EGF-like domain EB PF01683.18 AFZ80558.1 - 1 9.7 7.6 0.28 11.5 3.8 2.0 2 0 0 2 2 2 0 EB module Sin_N PF04801.13 AFZ80559.1 - 3.1e-29 102.5 0.4 1.1e-19 71.0 0.0 3.2 3 0 0 3 3 3 3 Sin-like protein conserved region DUF1160 PF06648.11 AFZ80559.1 - 0.061 13.3 0.1 0.19 11.8 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1160) CLIP PF12032.8 AFZ80559.1 - 0.095 13.0 0.5 9.1 6.7 0.1 3.1 2 1 0 2 2 2 0 Regulatory CLIP domain of proteinases Val_tRNA-synt_C PF10458.9 AFZ80560.1 - 0.06 13.6 0.4 0.06 13.6 0.4 2.5 2 0 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm LRR_3 PF07725.12 AFZ80560.1 - 0.063 13.2 0.3 0.28 11.1 0.3 2.2 1 0 0 1 1 1 0 Leucine Rich Repeat APG6_N PF17675.1 AFZ80560.1 - 0.11 13.0 20.7 0.031 14.8 15.7 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region Cep57_CLD_2 PF14197.6 AFZ80560.1 - 0.25 11.5 13.1 0.61 10.2 4.7 3.5 1 1 2 3 3 3 0 Centrosome localisation domain of PPC89 TolA_bind_tri PF16331.5 AFZ80560.1 - 0.44 10.7 12.4 2.2 8.4 0.7 2.6 1 1 1 2 2 2 0 TolA binding protein trimerisation TPR_MLP1_2 PF07926.12 AFZ80560.1 - 0.48 10.5 18.0 0.065 13.3 13.7 1.7 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 AFZ80560.1 - 0.76 9.1 10.7 1.3 8.3 10.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HIP1_clath_bdg PF16515.5 AFZ80560.1 - 1.2 9.8 15.5 0.65 10.6 11.1 2.7 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4200 PF13863.6 AFZ80560.1 - 1.5 9.3 27.5 0.1 13.0 9.0 3.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) Nucleoporin_FG2 PF15967.5 AFZ80560.1 - 1.6 7.2 5.4 2.3 6.6 5.4 1.2 1 0 0 1 1 1 0 Nucleoporin FG repeated region MetOD2 PF18548.1 AFZ80560.1 - 2 8.5 13.8 11 6.2 0.5 3.9 2 1 2 4 4 4 0 Metanogen output domain 2 CENP-H PF05837.12 AFZ80560.1 - 2.5 8.5 20.5 0.095 13.1 6.9 3.1 2 1 1 3 3 3 0 Centromere protein H (CENP-H) DUF641 PF04859.12 AFZ80560.1 - 3.2 8.1 10.6 1.4 9.3 6.7 2.4 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) ATG16 PF08614.11 AFZ80560.1 - 4.4 7.5 25.0 0.052 13.8 14.5 2.6 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) BST2 PF16716.5 AFZ80560.1 - 5.7 7.6 12.6 0.26 11.9 2.8 3.1 1 1 2 3 3 3 0 Bone marrow stromal antigen 2 YabA PF06156.13 AFZ80560.1 - 6.3 7.5 23.0 3.7 8.2 2.4 3.6 2 1 1 3 3 3 0 Initiation control protein YabA Tropomyosin_1 PF12718.7 AFZ80560.1 - 7.8 6.7 24.9 1.2 9.2 12.9 3.0 1 1 2 3 3 3 0 Tropomyosin like zf-C2H2_4 PF13894.6 AFZ80561.1 - 0.012 16.4 0.3 0.012 16.4 0.3 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 AFZ80561.1 - 0.016 15.6 0.7 0.016 15.6 0.7 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type Prosystemin PF07376.11 AFZ80561.1 - 0.051 13.1 0.1 0.087 12.3 0.1 1.3 1 0 0 1 1 1 0 Prosystemin zf-met PF12874.7 AFZ80561.1 - 0.78 10.2 4.1 1.1 9.7 0.1 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type OPA3 PF07047.12 AFZ80562.1 - 9.7e-31 106.2 0.0 1.3e-30 105.7 0.0 1.2 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) pRN1_helical PF13010.6 AFZ80562.1 - 0.025 14.5 1.3 0.035 14.1 1.3 1.2 1 0 0 1 1 1 0 Primase helical domain MMR_HSR1 PF01926.23 AFZ80563.1 - 1.1e-10 41.5 0.5 4.2e-10 39.7 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AFZ80563.1 - 1.8e-08 34.5 0.0 3.1e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 AFZ80563.1 - 0.00056 19.5 1.5 0.058 12.9 0.1 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.27 AFZ80563.1 - 0.0039 16.8 0.2 1.6 8.3 0.0 2.6 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 AFZ80563.1 - 0.0081 16.5 0.0 0.061 13.7 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain TniB PF05621.11 AFZ80563.1 - 0.011 15.1 0.0 0.022 14.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Dynamin_N PF00350.23 AFZ80563.1 - 0.02 15.0 0.2 0.38 10.8 0.0 2.3 2 0 0 2 2 2 0 Dynamin family FtsK_SpoIIIE PF01580.18 AFZ80563.1 - 0.028 13.8 0.1 0.077 12.3 0.0 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family Roc PF08477.13 AFZ80563.1 - 0.17 12.1 0.2 0.91 9.8 0.0 2.2 2 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase DEAD PF00270.29 AFZ80564.1 - 3e-29 102.0 0.2 6.8e-29 100.9 0.1 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AFZ80564.1 - 2.9e-24 85.6 0.0 7.3e-24 84.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AFZ80564.1 - 4e-05 23.7 0.0 6.6e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit phage_tail_N PF08400.10 AFZ80565.1 - 0.055 13.5 0.0 0.072 13.1 0.0 1.1 1 0 0 1 1 1 0 Prophage tail fibre N-terminal DUF846 PF05832.12 AFZ80566.1 - 8.6e-22 77.7 15.8 1.1e-21 77.4 15.8 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) TPR_2 PF07719.17 AFZ80568.1 - 2.3e-20 71.0 0.4 0.061 13.5 0.0 10.6 11 0 0 11 11 11 4 Tetratricopeptide repeat TPR_19 PF14559.6 AFZ80568.1 - 3.5e-19 69.1 6.7 0.0086 16.6 0.0 9.6 9 1 0 9 9 9 4 Tetratricopeptide repeat TPR_14 PF13428.6 AFZ80568.1 - 1.1e-12 47.6 8.4 3.7 8.6 0.0 9.6 9 1 2 11 11 11 4 Tetratricopeptide repeat TPR_8 PF13181.6 AFZ80568.1 - 1.9e-12 46.3 3.1 6.3 7.3 0.0 9.4 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_6 PF13174.6 AFZ80568.1 - 8.8e-09 35.4 3.3 0.01 16.4 0.1 8.0 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_1 PF00515.28 AFZ80568.1 - 1.3e-08 34.3 6.3 1.5 8.8 0.0 9.6 11 0 0 11 11 11 1 Tetratricopeptide repeat TPR_12 PF13424.6 AFZ80568.1 - 6.1e-07 29.6 9.7 0.44 10.9 0.0 8.5 8 2 2 10 10 9 2 Tetratricopeptide repeat TPR_4 PF07721.14 AFZ80568.1 - 0.00045 20.6 0.2 27 5.8 0.0 5.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 AFZ80568.1 - 0.00057 20.5 4.4 0.073 13.7 0.0 5.8 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_17 PF13431.6 AFZ80568.1 - 0.014 15.7 8.1 55 4.5 0.1 8.0 8 1 0 8 8 7 0 Tetratricopeptide repeat ANAPC3 PF12895.7 AFZ80568.1 - 0.079 13.2 15.8 1.7 8.9 0.0 7.1 8 0 0 8 8 8 0 Anaphase-promoting complex, cyclosome, subunit 3 RAP PF08373.10 AFZ80569.1 - 0.055 13.6 0.0 0.24 11.5 0.0 2.1 2 0 0 2 2 2 0 RAP domain NifU PF01106.17 AFZ80570.1 - 5.9e-19 68.0 0.0 8.1e-19 67.5 0.0 1.2 1 0 0 1 1 1 1 NifU-like domain DUF3627 PF12299.8 AFZ80571.1 - 0.036 14.1 0.8 0.81 9.8 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3627) Med1 PF10744.9 AFZ80571.1 - 0.12 11.4 0.1 0.25 10.3 0.1 1.5 2 0 0 2 2 2 0 Mediator of RNA polymerase II transcription subunit 1 PP2C PF00481.21 AFZ80572.1 - 9.5e-40 136.9 0.0 1.2e-39 136.5 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 AFZ80572.1 - 0.0089 16.0 0.0 2 8.3 0.0 2.2 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 AFZ80572.1 - 0.033 13.8 0.0 0.052 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein phosphatase 2C ABC1 PF03109.16 AFZ80573.1 - 5.4e-26 91.1 0.0 1.1e-25 90.1 0.0 1.6 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 AFZ80573.1 - 0.0022 18.0 0.0 3.8 7.4 0.0 3.1 3 0 0 3 3 3 2 Phosphotransferase enzyme family Pkinase PF00069.25 AFZ80573.1 - 0.011 15.1 0.0 0.04 13.3 0.0 1.9 2 0 0 2 2 2 0 Protein kinase domain Ribosomal_L33 PF00471.20 AFZ80574.1 - 8.8e-19 67.7 4.2 1.4e-18 67.0 4.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L33 ACBP PF00887.19 AFZ80575.1 - 6e-28 96.9 2.4 6.5e-28 96.8 2.4 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein AP2 PF00847.20 AFZ80576.1 - 5.5e-13 48.9 6.3 3.3e-12 46.4 2.5 2.5 2 0 0 2 2 2 2 AP2 domain Filaggrin PF03516.13 AFZ80576.1 - 0.76 10.6 3.4 2.7 8.8 3.4 1.9 1 0 0 1 1 1 0 Filaggrin EMA PF02488.15 AFZ80577.1 - 1.3e-39 136.4 8.5 1.5e-39 136.1 8.5 1.0 1 0 0 1 1 1 1 Merozoite Antigen Castor_Poll_mid PF06241.12 AFZ80578.1 - 0.035 14.1 0.0 0.095 12.7 0.0 1.7 1 0 0 1 1 1 0 Castor and Pollux, part of voltage-gated ion channel Phage_TAC_7 PF10109.9 AFZ80578.1 - 0.15 12.2 0.0 0.33 11.1 0.0 1.5 1 0 0 1 1 1 0 Phage tail assembly chaperone proteins, E, or 41 or 14 NPV_P10 PF05531.12 AFZ80579.1 - 0.086 13.3 0.7 0.19 12.2 0.7 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein PAP_central PF04928.17 AFZ80581.1 - 1.9e-96 321.9 0.1 2.5e-96 321.5 0.1 1.1 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 AFZ80581.1 - 1e-19 70.8 0.4 8.9e-10 38.5 0.0 2.4 1 1 1 2 2 2 2 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 AFZ80581.1 - 2.4e-06 27.7 0.0 5.6e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 AFZ80581.1 - 0.014 15.1 0.2 0.088 12.6 0.0 2.3 2 1 0 2 2 2 0 Nrap protein PAP/OAS-like domain Polbeta PF18765.1 AFZ80581.1 - 0.13 12.4 0.2 0.69 10.0 0.0 2.2 2 0 0 2 2 2 0 Polymerase beta, Nucleotidyltransferase DUF4269 PF14091.6 AFZ80581.1 - 0.17 12.1 0.4 0.69 10.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4269) ORC2 PF04084.14 AFZ80582.1 - 5.5e-30 104.4 2.1 9.4e-30 103.7 2.1 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 2 DUF835 PF05763.12 AFZ80582.1 - 0.0098 15.6 0.1 0.032 14.0 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF835) NACHT PF05729.12 AFZ80582.1 - 0.11 12.4 0.0 0.67 9.8 0.0 2.3 2 0 0 2 2 2 0 NACHT domain MFAP1 PF06991.11 AFZ80582.1 - 0.91 9.3 5.1 0.39 10.5 1.3 2.0 1 1 1 2 2 2 0 Microfibril-associated/Pre-mRNA processing SPT2 PF08243.11 AFZ80582.1 - 0.96 10.0 5.7 2.3 8.8 5.7 1.6 1 0 0 1 1 1 0 SPT2 chromatin protein DnaJ_C PF01556.18 AFZ80583.1 - 9.2e-35 119.9 0.0 1.2e-34 119.5 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 AFZ80583.1 - 1.3e-23 82.9 1.6 2e-23 82.2 1.6 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 AFZ80583.1 - 0.81 10.1 5.5 1.8 9.0 5.5 1.5 1 0 0 1 1 1 0 DnaJ central domain RAP PF08373.10 AFZ80584.1 - 3.3e-15 55.9 5.4 4.2e-15 55.6 3.2 2.5 2 0 0 2 2 2 1 RAP domain Polysacc_deac_2 PF04748.13 AFZ80584.1 - 0.19 10.9 0.8 0.62 9.2 0.0 1.9 2 0 0 2 2 2 0 Divergent polysaccharide deacetylase DUF3385 PF11865.8 AFZ80584.1 - 0.43 10.5 3.2 0.39 10.6 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3385) GatB_N PF02934.15 AFZ80586.1 - 1.4e-60 205.0 0.5 7.1e-55 186.3 0.1 2.1 2 0 0 2 2 2 2 GatB/GatE catalytic domain GatB_Yqey PF02637.18 AFZ80586.1 - 1.2e-10 41.5 0.1 2.3e-10 40.5 0.1 1.5 1 0 0 1 1 1 1 GatB domain DUF3209 PF11483.8 AFZ80586.1 - 0.076 13.5 0.2 0.51 10.8 0.2 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3209) RNA_pol_A_bac PF01000.26 AFZ80589.1 - 3e-23 82.3 0.0 8.2e-23 80.9 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 AFZ80589.1 - 3.7e-18 64.7 0.0 5.2e-18 64.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Dus PF01207.17 AFZ80590.1 - 1.2e-55 188.8 0.0 1.6e-55 188.4 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DUF3450 PF11932.8 AFZ80591.1 - 0.0051 16.1 1.1 0.0072 15.6 1.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) DUF4580 PF15162.6 AFZ80591.1 - 0.075 12.6 0.1 0.13 11.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4580) SL4P PF17618.2 AFZ80591.1 - 0.11 12.5 3.0 0.16 12.0 0.5 2.2 2 0 0 2 2 2 0 Uncharacterized Strongylid L4 protein CS PF04969.16 AFZ80594.1 - 1.8e-07 32.1 0.2 3.5e-07 31.2 0.2 1.5 1 0 0 1 1 1 1 CS domain DUF5053 PF16476.5 AFZ80594.1 - 0.14 11.9 2.5 0.52 10.0 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5053) Aminotran_5 PF00266.19 AFZ80596.1 - 3.9e-85 286.0 0.0 4.6e-85 285.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 AFZ80596.1 - 2.7e-05 23.7 0.0 6.1e-05 22.5 0.0 1.5 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.19 AFZ80596.1 - 0.003 16.4 0.0 0.0055 15.5 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 AFZ80596.1 - 0.024 13.9 0.0 0.043 13.1 0.0 1.4 1 1 0 1 1 1 0 Beta-eliminating lyase G6PD_bact PF10786.9 AFZ80596.1 - 0.17 11.4 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) WSD PF15613.6 AFZ80599.1 - 0.0013 19.2 0.2 0.031 14.7 0.2 3.1 1 1 0 1 1 1 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DUF220 PF02713.14 AFZ80599.1 - 0.13 12.4 0.7 19 5.4 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function DUF220 WHIM1 PF15612.6 AFZ80599.1 - 0.14 11.8 0.1 0.36 10.4 0.1 1.6 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 cwf18 PF08315.12 AFZ80602.1 - 1.3e-13 51.8 0.9 1.8e-13 51.4 0.9 1.2 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor Bromo_TP_like PF17027.5 AFZ80602.1 - 0.048 13.8 1.5 0.059 13.5 1.5 1.2 1 0 0 1 1 1 0 Histone-fold protein PA14 PF07691.12 AFZ80603.1 - 1.1e-23 83.7 0.0 4e-23 81.8 0.0 2.0 2 0 0 2 2 2 1 PA14 domain GLEYA PF10528.9 AFZ80603.1 - 0.0015 18.9 0.0 0.038 14.4 0.0 2.9 1 1 1 2 2 2 1 GLEYA domain fn2 PF00040.19 AFZ80603.1 - 0.013 15.8 0.7 0.039 14.2 0.7 1.9 1 0 0 1 1 1 0 Fibronectin type II domain SusF_SusE PF16411.5 AFZ80603.1 - 0.039 14.5 0.2 0.092 13.3 0.2 1.6 1 0 0 1 1 1 0 Outer membrane protein SusF_SusE Sortilin-Vps10 PF15902.5 AFZ80604.1 - 8.3e-107 357.7 2.2 1.7e-106 356.7 2.2 1.5 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 AFZ80604.1 - 1.1e-38 133.3 0.7 1.7e-38 132.7 0.7 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 AFZ80604.1 - 2.6e-06 26.6 16.4 1.1 9.5 0.1 8.4 9 0 0 9 9 9 2 BNR/Asp-box repeat BNR_6 PF15899.5 AFZ80604.1 - 0.049 13.7 0.2 65 4.0 0.0 4.5 3 0 0 3 3 3 0 BNR-Asp box repeat DUF4056 PF13265.6 AFZ80604.1 - 0.15 11.4 0.0 0.29 10.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4056) RIBIOP_C PF04950.12 AFZ80605.1 - 2.1e-96 322.8 0.0 3e-96 322.3 0.0 1.2 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 AFZ80605.1 - 4.2e-14 52.4 0.0 1.1e-13 51.1 0.0 1.8 1 0 0 1 1 1 1 AARP2CN (NUC121) domain CLAG PF03805.13 AFZ80606.1 - 2.2e-20 72.0 14.0 4e-11 41.3 10.2 2.8 3 0 0 3 3 3 2 Cytoadherence-linked asexual protein DUF5408 PF17402.2 AFZ80606.1 - 0.019 14.8 0.1 0.049 13.5 0.1 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5408) tRNA-synt_1g PF09334.11 AFZ80607.1 - 3.1e-91 306.0 0.1 6.3e-89 298.4 0.1 2.2 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 AFZ80607.1 - 9.4e-33 113.3 0.9 9.5e-18 63.8 0.0 3.5 1 1 2 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 AFZ80607.1 - 7.1e-15 55.1 0.0 3e-06 26.8 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 AFZ80607.1 - 3.7e-05 22.8 0.0 0.0011 18.0 0.0 2.4 2 0 0 2 2 2 1 tRNA synthetases class I (K) tRNA-synt_1d PF00750.19 AFZ80607.1 - 0.076 12.0 0.0 0.38 9.6 0.0 1.9 2 0 0 2 2 2 0 tRNA synthetases class I (R) Cyt-b5 PF00173.28 AFZ80609.1 - 8.8e-16 57.8 0.1 1.1e-15 57.5 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Insulin_TMD PF17870.1 AFZ80611.1 - 0.6 10.2 5.0 0.33 11.0 1.5 2.3 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment SPC25 PF06703.11 AFZ80611.1 - 3 7.6 6.6 0.37 10.6 1.3 2.1 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF5088 PF17008.5 AFZ80615.1 - 0.032 13.9 1.0 0.032 13.9 1.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5088) adh_short PF00106.25 AFZ80616.1 - 2.5e-32 111.9 0.1 2.8e-28 98.7 0.0 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 AFZ80616.1 - 6.2e-17 61.9 0.0 2.5e-16 59.9 0.0 1.8 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase GDP_Man_Dehyd PF16363.5 AFZ80616.1 - 2e-05 24.1 0.2 3.5e-05 23.4 0.2 1.3 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase KR PF08659.10 AFZ80616.1 - 4.8e-05 23.3 0.0 7e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 AFZ80616.1 - 0.0001 21.8 0.0 0.00014 21.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family MauJ PF17419.2 AFZ80617.1 - 0.086 12.3 0.0 0.1 12.0 0.0 1.0 1 0 0 1 1 1 0 Methylamine utilization protein MauJ FAINT PF04385.15 AFZ80618.1 - 5.2e-73 241.1 33.9 9.5e-08 32.0 0.3 14.8 14 0 0 14 14 14 14 Domain of unknown function, DUF529 DUF5043 PF16446.5 AFZ80618.1 - 0.11 12.5 2.3 5.8 6.9 0.0 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF5043) Pox_Ag35 PF03286.14 AFZ80619.1 - 0.084 12.7 8.4 0.15 11.9 8.4 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Gastrin PF00918.17 AFZ80619.1 - 0.17 12.9 3.4 0.32 12.0 3.4 1.4 1 0 0 1 1 1 0 Gastrin/cholecystokinin family CPSF100_C PF13299.6 AFZ80619.1 - 0.61 10.2 4.1 0.96 9.6 4.1 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SDA1 PF05285.12 AFZ80619.1 - 3 7.2 14.9 4.1 6.7 14.9 1.1 1 0 0 1 1 1 0 SDA1 TRAP_alpha PF03896.16 AFZ80619.1 - 3.1 6.9 9.5 5.1 6.2 9.5 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CDC45 PF02724.14 AFZ80619.1 - 3.5 5.8 10.2 4.4 5.5 10.2 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4366 PF14283.6 AFZ80619.1 - 6 6.9 7.3 15 5.6 6.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) PA28_beta PF02252.18 AFZ80620.1 - 6.2e-57 191.3 1.1 6.2e-57 191.3 1.1 1.4 2 0 0 2 2 2 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.18 AFZ80620.1 - 0.0041 17.1 0.6 0.0083 16.2 0.0 1.8 2 0 0 2 2 2 1 Proteasome activator pa28 alpha subunit BAR_2 PF10455.9 AFZ80620.1 - 0.015 14.5 0.9 0.02 14.0 0.9 1.2 1 1 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking CTP_synth_N PF06418.14 AFZ80621.1 - 1.2e-114 382.1 0.5 1.6e-114 381.7 0.5 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 AFZ80621.1 - 5.4e-47 160.0 0.0 9.1e-47 159.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 AFZ80621.1 - 0.0061 16.3 0.1 0.016 15.0 0.0 1.7 2 0 0 2 2 2 1 Peptidase C26 CbiA PF01656.23 AFZ80621.1 - 0.034 14.2 0.0 0.051 13.6 0.0 1.6 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain DNA_primase_S PF01896.19 AFZ80622.1 - 1.5e-51 175.0 0.3 2e-51 174.5 0.3 1.2 1 0 0 1 1 1 1 DNA primase small subunit SSB PF00436.25 AFZ80623.1 - 2.3e-09 37.2 0.1 3.6e-09 36.6 0.1 1.3 1 0 0 1 1 1 1 Single-strand binding protein family DUF1189 PF06691.11 AFZ80623.1 - 0.032 13.8 0.0 0.068 12.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) POLO_box PF00659.18 AFZ80623.1 - 0.042 14.1 0.1 2.1 8.6 0.0 2.5 1 1 1 2 2 2 0 POLO box duplicated region Trp_halogenase PF04820.14 AFZ80623.1 - 0.044 12.6 0.0 0.059 12.2 0.0 1.1 1 0 0 1 1 1 0 Tryptophan halogenase SAS-6_N PF16531.5 AFZ80624.1 - 2.5e-22 79.3 3.7 5.2e-22 78.2 3.7 1.6 1 0 0 1 1 1 1 Centriolar protein SAS N-terminal Arf PF00025.21 AFZ80625.1 - 1.2e-14 54.1 0.0 9e-14 51.3 0.0 1.9 1 1 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 AFZ80625.1 - 2.4e-06 27.1 0.1 6.1e-06 25.8 0.1 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 AFZ80625.1 - 1.1e-05 25.1 0.0 6.9e-05 22.5 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 AFZ80625.1 - 8.5e-05 22.6 0.0 0.00029 20.9 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 AFZ80625.1 - 0.00057 19.3 0.5 0.0014 18.0 0.5 1.6 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 AFZ80625.1 - 0.0047 16.5 0.0 0.023 14.3 0.0 1.9 1 1 0 1 1 1 1 Ras family Roc PF08477.13 AFZ80625.1 - 0.0053 17.0 0.1 0.013 15.7 0.1 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_14 PF13173.6 AFZ80625.1 - 0.011 15.8 0.4 0.067 13.2 0.4 2.3 1 1 0 1 1 1 0 AAA domain G-alpha PF00503.20 AFZ80625.1 - 0.025 13.8 0.3 0.084 12.0 0.0 1.8 1 1 1 2 2 2 0 G-protein alpha subunit T2SSE PF00437.20 AFZ80625.1 - 0.025 13.6 0.0 0.041 13.0 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_35 PF14516.6 AFZ80625.1 - 0.08 11.8 0.0 0.12 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain Pkinase PF00069.25 AFZ80627.1 - 1e-31 110.3 0.0 2.7e-30 105.6 0.0 2.1 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ80627.1 - 6.9e-17 61.6 0.0 9.7e-17 61.1 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 AFZ80627.1 - 2.5e-06 27.0 0.0 4.3e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 AFZ80627.1 - 0.0041 15.9 0.2 0.0054 15.5 0.2 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 AFZ80627.1 - 0.0046 16.9 0.1 0.0074 16.2 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 AFZ80627.1 - 0.0048 15.9 0.1 0.0075 15.3 0.1 1.3 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase Haspin_kinase PF12330.8 AFZ80627.1 - 0.017 14.1 0.1 0.028 13.4 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Myb_DNA-binding PF00249.31 AFZ80628.1 - 1.7e-19 69.7 4.3 7.9e-11 42.0 1.3 3.6 3 1 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AFZ80628.1 - 1e-13 51.3 5.0 3.3e-09 36.9 0.5 3.7 3 1 1 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 AFZ80628.1 - 0.0023 18.3 3.8 0.029 14.7 0.4 3.3 3 0 0 3 3 3 1 Myb/SANT-like DNA-binding domain FAINT PF04385.15 AFZ80629.1 - 4.8e-20 71.4 15.5 3.3e-05 23.8 0.0 5.6 5 1 0 5 5 5 4 Domain of unknown function, DUF529 DUF4251 PF14059.6 AFZ80629.1 - 0.1 12.6 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4251) GCD14 PF08704.10 AFZ80630.1 - 1.9e-61 207.9 0.3 6.6e-61 206.1 0.0 1.8 1 1 1 2 2 2 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.6 AFZ80630.1 - 4.6e-07 29.8 0.0 9.1e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.17 AFZ80630.1 - 2.1e-06 27.0 0.0 3.4e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 AFZ80630.1 - 0.0013 19.7 0.0 0.0025 18.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AFZ80630.1 - 0.038 14.7 0.0 0.15 12.8 0.0 2.1 2 1 0 2 2 2 0 Methyltransferase domain PCMT PF01135.19 AFZ80630.1 - 0.041 13.6 0.0 0.083 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF4715 PF15835.5 AFZ80630.1 - 0.087 12.9 0.0 0.23 11.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4715) CDP-OH_P_transf PF01066.21 AFZ80631.1 - 3.8e-10 40.4 0.1 3.8e-10 40.4 0.1 2.3 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase SNAP PF14938.6 AFZ80632.1 - 1.4e-71 241.2 4.5 1.6e-71 241.0 4.5 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 AFZ80632.1 - 4.6e-05 23.6 4.8 0.4 11.0 0.1 3.9 3 2 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 AFZ80632.1 - 0.00093 19.1 1.4 1.1 9.5 0.0 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 AFZ80632.1 - 0.0014 19.3 0.4 5.1 8.2 0.2 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 AFZ80632.1 - 0.002 18.1 12.3 0.0054 16.7 1.3 4.0 3 1 1 4 4 4 1 Tetratricopeptide repeat DUF2225 PF09986.9 AFZ80632.1 - 0.0076 16.0 1.3 0.51 10.0 0.1 2.4 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_1 PF00515.28 AFZ80632.1 - 0.013 15.3 11.8 0.091 12.6 1.1 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat RPN7 PF10602.9 AFZ80632.1 - 0.034 13.8 1.8 3.6 7.2 0.3 2.4 1 1 1 2 2 2 0 26S proteasome subunit RPN7 TPR_19 PF14559.6 AFZ80632.1 - 0.072 13.6 4.1 29 5.3 0.0 4.3 2 1 2 4 4 4 0 Tetratricopeptide repeat DUF4368 PF14287.6 AFZ80632.1 - 0.076 13.3 0.0 12 6.3 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4368) TPR_8 PF13181.6 AFZ80632.1 - 1.5 9.2 6.3 4.9 7.6 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat NSF PF02071.20 AFZ80632.1 - 1.9 9.6 19.1 5.7 8.2 0.4 6.2 6 0 0 6 6 6 0 Aromatic-di-Alanine (AdAR) repeat MIT PF04212.18 AFZ80632.1 - 3.4 7.8 9.1 0.85 9.7 0.2 3.0 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain WW PF00397.26 AFZ80633.1 - 1.5e-17 63.4 22.4 5.9e-10 39.0 3.9 3.7 3 0 0 3 3 3 2 WW domain FF PF01846.19 AFZ80633.1 - 5.4e-11 42.5 0.5 2.5e-06 27.6 0.6 4.5 5 0 0 5 5 5 2 FF domain FAINT PF04385.15 AFZ80633.1 - 0.0006 19.8 0.0 0.0033 17.5 0.0 2.3 1 1 1 2 2 2 1 Domain of unknown function, DUF529 Glyco_hyd_101C PF17451.2 AFZ80633.1 - 0.0026 18.1 5.6 1.7 9.0 1.0 3.5 2 1 1 3 3 3 2 Glycosyl hydrolase 101 beta sandwich domain CTP_transf_like PF01467.26 AFZ80634.1 - 2.5e-52 176.9 0.5 4.6e-30 104.7 0.2 2.4 2 0 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 AFZ80634.1 - 0.081 12.8 0.1 1.9 8.4 0.0 2.5 2 0 0 2 2 2 0 FAD synthetase FAINT PF04385.15 AFZ80635.1 - 5.8e-13 48.7 0.8 2.4e-09 37.1 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Bt_P21 PF05560.11 AFZ80635.1 - 0.094 12.3 0.2 2 7.9 0.1 2.1 2 0 0 2 2 2 0 Bacillus thuringiensis P21 molecular chaperone protein DUF2070 PF09843.9 AFZ80636.1 - 8.1 4.6 12.6 12 4.0 12.6 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Sec20 PF03908.13 AFZ80637.1 - 6.9e-06 25.9 1.8 2e-05 24.4 1.8 1.8 1 0 0 1 1 1 1 Sec20 TfoX_C PF04994.13 AFZ80637.1 - 0.034 14.2 0.2 0.08 13.0 0.2 1.6 1 0 0 1 1 1 0 TfoX C-terminal domain DUF749 PF05370.11 AFZ80637.1 - 0.12 12.4 1.9 0.27 11.3 1.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF749) Collagen PF01391.18 AFZ80639.1 - 0.028 14.2 22.1 0.063 13.0 22.1 1.6 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Het-C PF07217.11 AFZ80641.1 - 0.013 14.1 1.5 0.015 13.9 1.5 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C FAD_oxidored PF12831.7 AFZ80641.1 - 0.064 12.6 0.1 0.064 12.6 0.1 1.1 1 0 0 1 1 1 0 FAD dependent oxidoreductase HEPN_Swt1 PF18731.1 AFZ80641.1 - 0.14 12.5 3.0 0.3 11.4 2.1 1.8 2 0 0 2 2 2 0 Swt1-like HEPN DUF272 PF03312.15 AFZ80642.1 - 0.004 17.4 0.2 0.0047 17.2 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF272) FAINT PF04385.15 AFZ80643.1 - 5.2e-13 48.9 1.6 4.1e-09 36.4 0.4 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Phage_holin_7_1 PF16081.5 AFZ80644.1 - 0.19 11.9 0.0 0.87 9.8 0.0 1.9 2 0 0 2 2 2 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family Beta_lactamase3 PF17030.5 AFZ80645.1 - 0.043 13.1 0.0 0.09 12.0 0.0 1.5 1 0 0 1 1 1 0 Putative beta-lactamase-like family UBA2_C PF16195.5 AFZ80646.1 - 1.6 9.5 4.7 3 8.6 0.4 2.5 1 1 1 2 2 2 0 SUMO-activating enzyme subunit 2 C-terminus FAINT PF04385.15 AFZ80649.1 - 5.1e-21 74.5 9.8 3.4e-09 36.6 1.2 3.7 3 0 0 3 3 3 3 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ80651.1 - 3e-16 59.2 8.5 0.0098 15.9 0.6 6.3 5 2 0 5 5 5 5 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ80653.1 - 1.4e-12 47.5 0.0 8.9e-07 28.9 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Peptidase_C1 PF00112.23 AFZ80654.1 - 1.9e-29 103.3 0.0 3.3e-29 102.5 0.0 1.3 1 0 0 1 1 1 1 Papain family cysteine protease zf-UBP PF02148.19 AFZ80655.1 - 1.7e-13 50.7 4.8 3.1e-13 49.8 4.8 1.4 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH PF00443.29 AFZ80655.1 - 1.3e-06 28.1 0.1 4.6e-06 26.3 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase HTH_WhiA PF02650.14 AFZ80655.1 - 0.078 13.3 0.0 1.1 9.7 0.0 2.4 2 0 0 2 2 2 0 WhiA C-terminal HTH domain UCH PF00443.29 AFZ80658.1 - 1.5e-18 67.3 0.0 1.6e-18 67.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase FAINT PF04385.15 AFZ80659.1 - 0.13 12.3 0.3 0.23 11.6 0.2 1.5 1 1 0 1 1 1 0 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ80661.1 - 1.8e-13 50.4 0.3 1.7e-05 24.8 0.1 3.3 2 0 0 2 2 2 2 Domain of unknown function, DUF529 DUF4330 PF14221.6 AFZ80662.1 - 0.042 14.1 0.1 0.093 12.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4330) Cecropin PF00272.19 AFZ80662.1 - 0.074 12.8 1.5 0.15 11.8 0.0 2.1 2 0 0 2 2 2 0 Cecropin family VSG_B PF13206.6 AFZ80662.1 - 0.14 11.4 6.7 0.02 14.1 2.8 1.5 2 0 0 2 2 2 0 Trypanosomal VSG domain Hydrolase_3 PF08282.12 AFZ80663.1 - 6.1e-34 117.9 0.0 7.4e-34 117.6 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 AFZ80663.1 - 0.00032 20.3 0.0 0.035 13.6 0.0 2.5 3 0 0 3 3 3 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 AFZ80663.1 - 0.053 13.8 0.0 2.1 8.5 0.0 2.4 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase RVT_1 PF00078.27 AFZ80664.1 - 5.8e-35 120.8 0.1 1e-34 120.0 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AcetDehyd-dimer PF09290.11 AFZ80665.1 - 0.089 13.0 0.9 0.58 10.4 0.2 2.8 2 0 0 2 2 2 0 Prokaryotic acetaldehyde dehydrogenase, dimerisation 7TM_GPCR_Srd PF10317.9 AFZ80665.1 - 0.1 11.8 0.1 0.23 10.6 0.1 1.6 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srd MscS_porin PF12795.7 AFZ80665.1 - 0.14 11.7 7.9 0.033 13.7 1.0 3.1 3 0 0 3 3 3 0 Mechanosensitive ion channel porin domain Herpes_UL49_5 PF05702.11 AFZ80665.1 - 0.16 12.1 0.1 0.58 10.3 0.0 1.9 2 0 0 2 2 2 0 Herpesvirus UL49.5 envelope/tegument protein DUF5402 PF17393.2 AFZ80665.1 - 0.2 11.6 1.8 0.91 9.5 1.2 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5402) DASH_Duo1 PF08651.10 AFZ80665.1 - 0.76 9.6 7.5 0.84 9.4 0.1 4.8 4 0 0 4 4 4 0 DASH complex subunit Duo1 DUF4407 PF14362.6 AFZ80665.1 - 5.1 6.4 20.0 1.1 8.5 6.0 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) DUF948 PF06103.11 AFZ80665.1 - 8.3 6.7 8.8 5.9 7.2 0.1 4.8 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) MCM PF00493.23 AFZ80667.1 - 5.4e-96 320.0 0.0 9.7e-96 319.2 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 AFZ80667.1 - 1.2e-22 80.1 1.1 1.6e-22 79.7 0.1 1.7 2 0 0 2 2 2 1 MCM OB domain MCM_lid PF17855.1 AFZ80667.1 - 2.5e-22 79.1 0.5 5.4e-22 78.0 0.5 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 AFZ80667.1 - 1.7e-07 30.8 0.1 5.6e-06 25.9 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI MCM_N PF14551.6 AFZ80667.1 - 4.3e-05 24.0 0.9 0.0002 21.9 1.1 2.0 1 1 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.14 AFZ80667.1 - 0.00028 20.9 0.0 0.001 19.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 AFZ80667.1 - 0.023 14.6 0.0 0.046 13.6 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 AFZ80667.1 - 0.12 12.1 0.0 1.8 8.2 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF5595 PF18077.1 AFZ80667.1 - 7.4 6.7 8.7 7.6 6.7 1.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF5595) FAINT PF04385.15 AFZ80668.1 - 0.013 15.6 0.0 0.028 14.5 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function, DUF529 DUF4671 PF15710.5 AFZ80671.1 - 0.025 13.4 0.4 0.038 12.8 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4671) DUF3212 PF11486.8 AFZ80671.1 - 0.092 12.8 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3212) FAINT PF04385.15 AFZ80672.1 - 0.007 16.4 0.0 0.11 12.6 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function, DUF529 LuxS PF02664.15 AFZ80672.1 - 0.053 13.2 0.0 0.095 12.4 0.0 1.4 1 0 0 1 1 1 0 S-Ribosylhomocysteinase (LuxS) CBF PF03914.17 AFZ80673.1 - 6.8e-08 32.7 5.2 5.2e-07 29.9 0.9 3.2 2 1 1 3 3 3 1 CBF/Mak21 family Cnd3 PF12719.7 AFZ80673.1 - 0.0051 16.0 1.3 0.028 13.6 0.4 2.5 2 1 1 3 3 3 1 Nuclear condensing complex subunits, C-term domain FAINT PF04385.15 AFZ80674.1 - 3.2e-05 23.9 0.3 5.5e-05 23.1 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 TRSP PF12500.8 AFZ80675.1 - 0.1 12.5 0.1 0.26 11.2 0.1 1.7 1 0 0 1 1 1 0 TRSP domain C terminus to PRTase_2 Skp1 PF01466.19 AFZ80675.1 - 0.35 11.0 2.0 1 9.5 2.0 1.7 1 0 0 1 1 1 0 Skp1 family, dimerisation domain ATC_hydrolase PF14196.6 AFZ80677.1 - 0.11 13.3 0.0 0.2 12.5 0.0 1.4 1 0 0 1 1 1 0 L-2-amino-thiazoline-4-carboxylic acid hydrolase Tetraspanin PF00335.20 AFZ80678.1 - 0.02 14.6 1.7 0.023 14.4 1.7 1.3 1 0 0 1 1 1 0 Tetraspanin family DUF3808 PF10300.9 AFZ80678.1 - 0.034 12.9 0.1 0.04 12.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) BRCC36_C PF18110.1 AFZ80678.1 - 0.046 13.9 0.1 0.076 13.2 0.1 1.5 1 0 0 1 1 1 0 BRCC36 C-terminal helical domain Brr6_like_C_C PF10104.9 AFZ80678.1 - 0.067 13.0 0.1 0.067 13.0 0.1 1.9 2 0 0 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain ABC2_membrane_2 PF12679.7 AFZ80678.1 - 0.11 11.7 7.5 3.6 6.8 0.0 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein MrpF_PhaF PF04066.13 AFZ80678.1 - 0.46 10.9 4.8 1.9 9.0 1.7 2.5 1 1 1 2 2 2 0 Multiple resistance and pH regulation protein F (MrpF / PhaF) RseC_MucC PF04246.12 AFZ80678.1 - 7.8 6.5 7.6 20 5.1 2.8 2.3 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC SnoaL PF07366.12 AFZ80680.1 - 0.0013 18.5 0.4 0.078 12.8 0.1 2.5 1 1 1 2 2 2 1 SnoaL-like polyketide cyclase Baculo_PEP_C PF04513.12 AFZ80680.1 - 0.026 14.6 5.7 0.23 11.5 0.9 3.2 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.11 AFZ80680.1 - 0.028 14.7 8.4 25 5.2 0.1 5.0 3 2 0 3 3 3 0 Bacterial protein of unknown function (DUF948) HisKA PF00512.25 AFZ80680.1 - 0.031 14.3 0.6 13 5.9 0.1 3.5 3 0 0 3 3 3 0 His Kinase A (phospho-acceptor) domain DUF3391 PF11871.8 AFZ80680.1 - 0.13 12.8 0.2 0.13 12.8 0.2 2.8 4 0 0 4 4 3 0 Domain of unknown function (DUF3391) PspB PF06667.12 AFZ80680.1 - 0.17 11.9 0.2 0.17 11.9 0.2 2.5 4 0 0 4 4 3 0 Phage shock protein B BST2 PF16716.5 AFZ80680.1 - 0.2 12.3 2.8 5.7 7.6 0.1 2.8 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 DUF1664 PF07889.12 AFZ80680.1 - 1.9 8.6 14.0 6.3 6.8 1.5 4.1 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) Vps54_N PF10475.9 AFZ80680.1 - 3.1 7.0 6.6 0.5 9.6 0.4 2.5 2 1 0 3 3 3 0 Vacuolar-sorting protein 54, of GARP complex Laminin_II PF06009.12 AFZ80680.1 - 3.5 7.6 14.9 10 6.2 0.9 4.0 3 2 1 4 4 4 0 Laminin Domain II TMPIT PF07851.13 AFZ80680.1 - 5.5 6.1 7.4 26 3.9 0.2 3.0 3 0 0 3 3 3 0 TMPIT-like protein Spc7 PF08317.11 AFZ80680.1 - 9.6 5.0 13.8 0.4 9.5 0.9 2.9 2 2 1 3 3 3 0 Spc7 kinetochore protein Ctr PF04145.15 AFZ80681.1 - 2.2e-08 34.8 16.8 0.00013 22.6 11.1 2.3 1 1 1 2 2 2 2 Ctr copper transporter family DUF5391 PF17369.2 AFZ80681.1 - 1.7 8.7 10.3 1.8 8.6 9.3 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5391) Ribosomal_S19 PF00203.21 AFZ80682.1 - 3e-33 113.5 0.0 4.4e-33 113.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 ArgoMid PF16487.5 AFZ80682.1 - 0.18 12.1 0.0 13 6.1 0.0 2.4 3 0 0 3 3 3 0 Mid domain of argonaute Collagen PF01391.18 AFZ80683.1 - 0.0075 16.0 11.3 0.015 15.1 11.3 1.4 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) FAINT PF04385.15 AFZ80684.1 - 1.1e-08 35.0 4.2 1.2e-05 25.2 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 EBP PF05241.12 AFZ80684.1 - 0.023 14.2 0.1 1.8 8.0 0.0 2.2 2 0 0 2 2 2 0 Emopamil binding protein Fer2 PF00111.27 AFZ80687.1 - 1.4e-17 63.4 0.8 2.3e-17 62.7 0.8 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain FAINT PF04385.15 AFZ80688.1 - 2.9e-20 72.1 21.5 8.8e-07 28.9 2.2 5.7 5 0 0 5 5 5 5 Domain of unknown function, DUF529 TPR_2 PF07719.17 AFZ80689.1 - 5.1e-06 26.2 1.3 9.6e-05 22.2 0.7 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 AFZ80689.1 - 1.3e-05 24.8 0.7 8.6e-05 22.2 0.4 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 AFZ80689.1 - 0.00044 19.9 0.3 0.13 12.0 0.0 2.7 2 0 0 2 2 2 2 TPR repeat TPR_8 PF13181.6 AFZ80689.1 - 0.0047 17.0 2.0 0.27 11.6 0.2 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 AFZ80689.1 - 0.0095 16.2 0.1 0.023 15.0 0.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat ChAPs PF09295.10 AFZ80689.1 - 0.038 13.0 0.0 0.053 12.5 0.0 1.2 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_17 PF13431.6 AFZ80689.1 - 0.069 13.6 0.1 1.3 9.6 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat CTP_transf_1 PF01148.20 AFZ80690.1 - 2e-55 188.5 28.4 9.5e-54 182.9 18.3 2.1 2 0 0 2 2 2 2 Cytidylyltransferase family Ribosomal_L16 PF00252.18 AFZ80692.1 - 4.2e-14 52.7 0.1 9.9e-14 51.5 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e EAP30 PF04157.16 AFZ80693.1 - 2.9e-39 134.8 0.1 3.3e-39 134.6 0.1 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family BACK PF07707.15 AFZ80693.1 - 0.029 14.4 0.1 0.066 13.3 0.1 1.5 1 0 0 1 1 1 0 BTB And C-terminal Kelch Pox_D5 PF03288.16 AFZ80693.1 - 0.071 13.6 0.1 21 5.7 0.1 2.5 2 0 0 2 2 2 0 Poxvirus D5 protein-like FAINT PF04385.15 AFZ80694.1 - 3.2e-06 27.1 10.0 0.00027 20.9 1.9 3.3 3 1 0 3 3 3 2 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ80695.1 - 1.5e-07 31.4 4.8 0.0016 18.5 0.6 2.9 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Pre-PUA PF17832.1 AFZ80697.1 - 4.3e-26 91.4 0.3 6.7e-26 90.8 0.3 1.3 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 AFZ80697.1 - 3.1e-16 59.1 0.0 4.6e-16 58.6 0.0 1.3 1 0 0 1 1 1 1 PUA domain FlgM PF04316.13 AFZ80698.1 - 0.072 13.5 1.2 0.18 12.2 1.2 1.8 1 1 0 1 1 1 0 Anti-sigma-28 factor, FlgM Hormone_recep PF00104.30 AFZ80698.1 - 0.098 12.2 0.1 0.16 11.6 0.1 1.3 1 0 0 1 1 1 0 Ligand-binding domain of nuclear hormone receptor Tic22 PF04278.12 AFZ80700.1 - 0.057 12.8 0.0 1.1 8.6 0.0 1.9 1 1 1 2 2 2 0 Tic22-like family Thioredoxin_2 PF13098.6 AFZ80701.1 - 0.0058 17.1 0.7 0.011 16.2 0.7 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain Peptidase_C1 PF00112.23 AFZ80702.1 - 2.2e-62 211.0 0.0 3.3e-62 210.4 0.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 AFZ80702.1 - 4.1e-07 30.3 7.2 4.5e-07 30.2 5.4 2.0 2 0 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 AFZ80702.1 - 1.6e-06 27.1 0.2 0.00027 19.9 0.1 2.2 2 0 0 2 2 2 2 Peptidase C1-like family REC1 PF18501.1 AFZ80702.1 - 0.0045 16.9 0.4 0.0078 16.1 0.4 1.3 1 0 0 1 1 1 1 Alpha helical recognition lobe domain EIIA-man PF03610.16 AFZ80703.1 - 0.0094 16.2 0.2 0.052 13.8 0.0 2.3 2 0 0 2 2 2 1 PTS system fructose IIA component CHASE3 PF05227.13 AFZ80703.1 - 0.29 11.0 5.7 0.26 11.2 0.9 2.7 3 0 0 3 3 3 0 CHASE3 domain TPR_MLP1_2 PF07926.12 AFZ80703.1 - 3.6 7.7 10.3 3.3 7.8 1.5 3.1 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein Skp1 PF01466.19 AFZ80704.1 - 1.2 9.3 4.7 0.49 10.5 1.6 1.9 2 0 0 2 2 2 0 Skp1 family, dimerisation domain VCBS PF13517.6 AFZ80705.1 - 4.5e-20 72.0 18.9 5.5e-07 30.1 0.2 5.8 4 2 1 5 5 5 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 AFZ80705.1 - 1.6e-12 47.3 17.9 0.0018 18.3 0.1 6.4 7 0 0 7 7 7 5 FG-GAP repeat TcdB_toxin_midN PF12256.8 AFZ80705.1 - 3.7e-05 23.2 1.3 5.5 6.3 0.0 4.7 5 1 1 6 6 6 3 Insecticide toxin TcdB middle/N-terminal region Hydrolase_3 PF08282.12 AFZ80706.1 - 7.7e-36 124.1 0.0 8.9e-35 120.6 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 AFZ80706.1 - 2.1e-06 27.5 0.0 0.039 13.5 0.0 2.3 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 AFZ80706.1 - 0.0039 17.5 0.1 0.26 11.5 0.0 2.9 3 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 AFZ80706.1 - 0.0055 16.8 0.0 0.028 14.5 0.0 2.0 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase ABC_tran PF00005.27 AFZ80707.1 - 8.6e-30 104.0 0.0 2.4e-16 60.5 0.0 2.6 2 1 0 2 2 2 2 ABC transporter AAA_16 PF13191.6 AFZ80707.1 - 7.7e-05 23.1 0.0 0.073 13.5 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 AFZ80707.1 - 0.00012 21.7 1.1 0.11 12.2 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_30 PF13604.6 AFZ80707.1 - 0.00037 20.3 0.1 0.24 11.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 AFZ80707.1 - 0.00055 19.9 0.5 0.046 13.6 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 AFZ80707.1 - 0.0014 18.5 2.6 0.15 11.9 0.0 3.0 2 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system Zeta_toxin PF06414.12 AFZ80707.1 - 0.0026 17.1 0.2 0.58 9.4 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_22 PF13401.6 AFZ80707.1 - 0.0035 17.6 0.0 1.1 9.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 AFZ80707.1 - 0.0036 16.3 0.5 0.0086 15.1 0.0 1.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB DnaB_C PF03796.15 AFZ80707.1 - 0.0045 16.3 0.0 0.11 11.8 0.0 2.2 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain FtsK_SpoIIIE PF01580.18 AFZ80707.1 - 0.0072 15.7 0.5 0.97 8.7 0.1 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family T2SSE PF00437.20 AFZ80707.1 - 0.0083 15.2 0.6 3.3 6.7 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_18 PF13238.6 AFZ80707.1 - 0.011 16.3 0.1 2.9 8.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 AFZ80707.1 - 0.014 15.5 3.1 0.18 11.9 0.1 2.8 3 0 0 3 3 3 0 Helicase HerA, central domain MMR_HSR1 PF01926.23 AFZ80707.1 - 0.016 15.3 0.3 0.19 11.8 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase NACHT PF05729.12 AFZ80707.1 - 0.027 14.4 0.4 5.6 6.9 0.1 2.5 2 0 0 2 2 2 0 NACHT domain SMC_N PF02463.19 AFZ80707.1 - 0.029 13.8 0.4 0.38 10.2 0.1 2.4 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 AFZ80707.1 - 0.038 14.2 0.0 0.088 13.1 0.0 1.6 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 AFZ80707.1 - 0.049 14.1 3.5 4.8 7.6 0.1 2.6 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 AFZ80707.1 - 0.051 13.4 0.3 9.2 6.0 0.0 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein NB-ARC PF00931.22 AFZ80707.1 - 0.072 12.3 0.5 1 8.5 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain AAA_25 PF13481.6 AFZ80707.1 - 0.084 12.4 0.0 2.1 7.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 AFZ80707.1 - 0.088 12.4 0.7 11 5.6 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_15 PF13175.6 AFZ80707.1 - 0.11 12.2 0.9 2.4 7.8 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain TsaE PF02367.17 AFZ80707.1 - 0.16 12.0 0.3 6.8 6.7 0.2 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF3671 PF12420.8 AFZ80708.1 - 1.1 9.4 6.5 2.5 8.2 5.9 1.8 1 1 1 2 2 2 0 Protein of unknown function Oleosin PF01277.17 AFZ80708.1 - 5.5 6.8 9.9 0.65 9.8 4.9 2.1 2 1 1 3 3 3 0 Oleosin FAINT PF04385.15 AFZ80710.1 - 1.8e-05 24.7 0.0 3e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function, DUF529 MMR_HSR1 PF01926.23 AFZ80712.1 - 6.3e-12 45.6 1.2 1.5e-11 44.3 0.1 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase GN3L_Grn1 PF08701.11 AFZ80712.1 - 2.8e-07 30.5 14.7 2.8e-07 30.5 14.7 2.8 2 1 0 2 2 2 1 GNL3L/Grn1 putative GTPase RsgA_GTPase PF03193.16 AFZ80712.1 - 6.8e-05 22.8 0.1 0.0045 16.9 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 AFZ80712.1 - 0.00017 21.2 0.6 0.00036 20.1 0.1 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B cobW PF02492.19 AFZ80712.1 - 0.00034 20.3 0.2 0.61 9.7 0.0 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AIG1 PF04548.16 AFZ80712.1 - 0.0022 17.3 0.4 0.0067 15.8 0.1 1.9 2 0 0 2 2 2 1 AIG1 family GTP_EFTU PF00009.27 AFZ80712.1 - 0.0027 17.3 0.1 2.3 7.7 0.0 2.6 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain Roc PF08477.13 AFZ80712.1 - 0.0041 17.3 0.1 0.013 15.7 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 AFZ80712.1 - 0.0046 17.0 6.7 0.47 10.5 0.1 3.5 2 2 1 3 3 3 2 Dynamin family AAA_16 PF13191.6 AFZ80712.1 - 0.05 14.0 0.0 0.2 12.1 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Ras PF00071.22 AFZ80712.1 - 0.062 12.9 0.3 0.21 11.2 0.0 1.9 2 0 0 2 2 2 0 Ras family Septin PF00735.18 AFZ80712.1 - 0.068 12.4 0.0 0.068 12.4 0.0 1.8 2 0 0 2 2 2 0 Septin Ribosomal_L6e PF01159.19 AFZ80712.1 - 8.7 6.9 9.4 2.4 8.7 2.7 2.6 2 1 0 2 2 2 0 Ribosomal protein L6e T3SchapCesA PF11439.8 AFZ80713.1 - 0.3 11.3 0.1 0.3 11.3 0.1 2.7 3 0 0 3 3 3 0 Type III secretion system filament chaperone CesA Med8 PF10232.9 AFZ80713.1 - 0.62 9.6 3.0 0.58 9.7 0.9 1.8 2 0 0 2 2 2 0 Mediator of RNA polymerase II transcription complex subunit 8 MFS_1 PF07690.16 AFZ80714.1 - 4.6e-09 35.7 38.6 5.7e-09 35.4 13.3 3.2 2 1 1 3 3 3 2 Major Facilitator Superfamily MFS_1_like PF12832.7 AFZ80714.1 - 0.14 10.9 18.7 0.11 11.3 8.7 2.9 1 1 2 3 3 3 0 MFS_1 like family AhpC-TSA PF00578.21 AFZ80715.1 - 2.2e-34 118.1 0.0 2.8e-34 117.7 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AFZ80715.1 - 1.9e-13 50.3 0.0 2.4e-13 50.0 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 AFZ80715.1 - 6.7e-09 35.4 0.1 1.2e-08 34.6 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin SCO1-SenC PF02630.14 AFZ80715.1 - 0.13 12.1 0.1 0.24 11.3 0.1 1.3 1 0 0 1 1 1 0 SCO1/SenC FAINT PF04385.15 AFZ80716.1 - 2.7e-05 24.2 0.0 6.2e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function, DUF529 dCMP_cyt_deam_2 PF08211.12 AFZ80716.1 - 0.077 13.2 0.0 0.17 12.1 0.0 1.5 2 0 0 2 2 2 0 Cytidine and deoxycytidylate deaminase zinc-binding region RRM_1 PF00076.22 AFZ80718.1 - 7.1e-25 86.6 1.0 2.3e-16 59.4 0.1 4.4 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AFZ80718.1 - 0.0026 17.6 0.0 0.039 13.8 0.0 2.9 3 1 0 3 3 3 1 Occluded RNA-recognition motif CAP PF00188.26 AFZ80718.1 - 0.019 15.8 0.0 0.054 14.3 0.0 1.8 1 0 0 1 1 1 0 Cysteine-rich secretory protein family MAM1 PF10434.9 AFZ80718.1 - 0.03 13.9 0.3 0.093 12.3 0.5 1.6 2 0 0 2 2 2 0 Monopolin complex protein MAM1 PHD PF00628.29 AFZ80720.1 - 1.5e-19 69.6 58.3 2.7e-09 36.7 11.9 4.0 3 1 2 5 5 5 3 PHD-finger PHD_2 PF13831.6 AFZ80720.1 - 0.00022 20.7 2.7 0.00022 20.7 2.7 5.9 5 2 1 6 6 6 2 PHD-finger Adenylsucc_synt PF00709.21 AFZ80721.1 - 2.6e-147 491.1 0.0 3.1e-147 490.9 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase AAA PF00004.29 AFZ80723.1 - 1.1e-44 152.1 0.0 5.4e-44 149.8 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AFZ80723.1 - 3.9e-10 39.4 0.0 9.5e-10 38.1 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 AFZ80723.1 - 2.8e-08 33.9 0.1 1.3e-07 31.7 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 AFZ80723.1 - 2.8e-07 30.8 0.0 8.9e-07 29.2 0.0 1.9 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) Prot_ATP_ID_OB PF16450.5 AFZ80723.1 - 4.1e-07 29.9 0.2 9.4e-07 28.7 0.0 1.7 2 0 0 2 2 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 AFZ80723.1 - 2.1e-06 28.2 0.4 0.0016 18.8 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_18 PF13238.6 AFZ80723.1 - 1.1e-05 26.0 0.0 3.3e-05 24.4 0.0 1.9 2 1 0 2 2 1 1 AAA domain AAA_22 PF13401.6 AFZ80723.1 - 6.9e-05 23.1 0.8 0.013 15.8 0.8 2.7 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 AFZ80723.1 - 7.4e-05 22.5 0.0 0.00028 20.7 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 AFZ80723.1 - 8.8e-05 21.8 0.0 0.00022 20.5 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 AFZ80723.1 - 0.00046 19.9 0.1 0.078 12.7 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_28 PF13521.6 AFZ80723.1 - 0.001 19.3 0.0 0.0023 18.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 AFZ80723.1 - 0.0019 17.5 0.0 0.0065 15.7 0.0 1.9 1 1 1 2 2 2 1 TIP49 P-loop domain Mg_chelatase PF01078.21 AFZ80723.1 - 0.0019 17.6 0.2 0.0048 16.3 0.1 1.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 AFZ80723.1 - 0.002 18.5 0.0 0.0063 16.9 0.0 1.9 2 0 0 2 2 1 1 RNA helicase NTPase_1 PF03266.15 AFZ80723.1 - 0.0022 17.9 0.0 0.14 12.0 0.0 2.9 3 0 0 3 3 3 1 NTPase IstB_IS21 PF01695.17 AFZ80723.1 - 0.0024 17.6 0.0 0.0069 16.1 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 AFZ80723.1 - 0.0048 16.9 0.2 0.015 15.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 AFZ80723.1 - 0.006 16.3 0.1 0.014 15.1 0.1 1.7 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 AFZ80723.1 - 0.0063 16.5 0.0 0.01 15.8 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 AFZ80723.1 - 0.0081 16.1 0.1 0.12 12.3 0.0 2.3 2 0 0 2 2 2 1 NACHT domain AAA_7 PF12775.7 AFZ80723.1 - 0.01 15.4 0.2 0.044 13.3 0.0 2.0 2 1 0 2 2 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 AFZ80723.1 - 0.011 15.3 0.3 0.042 13.4 0.1 1.7 1 1 0 2 2 2 0 AAA domain AAA_17 PF13207.6 AFZ80723.1 - 0.015 15.8 0.1 0.042 14.3 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_33 PF13671.6 AFZ80723.1 - 0.016 15.4 0.0 0.041 14.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 AFZ80723.1 - 0.022 13.9 0.0 0.043 12.9 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 TniB PF05621.11 AFZ80723.1 - 0.054 12.9 0.0 4.3 6.7 0.0 2.6 2 0 0 2 2 2 0 Bacterial TniB protein AAA_3 PF07726.11 AFZ80723.1 - 0.06 13.2 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF2524 PF10732.9 AFZ80723.1 - 0.064 13.6 0.3 0.12 12.7 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2524) NB-ARC PF00931.22 AFZ80723.1 - 0.086 12.0 0.0 0.22 10.7 0.0 1.8 1 0 0 1 1 1 0 NB-ARC domain AAA_11 PF13086.6 AFZ80723.1 - 0.12 12.2 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 AFZ80723.1 - 0.12 12.4 0.0 0.31 11.2 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain APG6_N PF17675.1 AFZ80723.1 - 0.14 12.7 3.1 0.26 11.8 3.1 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region AAA_30 PF13604.6 AFZ80723.1 - 0.19 11.4 0.1 0.39 10.4 0.1 1.6 1 1 0 1 1 1 0 AAA domain SNF2_N PF00176.23 AFZ80724.1 - 6.9e-61 205.9 0.2 1.5e-60 204.8 0.2 1.5 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AFZ80724.1 - 2.2e-17 63.4 0.0 1.1e-16 61.2 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AFZ80724.1 - 1.2e-08 35.2 0.3 1.4e-06 28.5 0.0 3.0 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 AFZ80724.1 - 5.7e-07 29.5 0.0 0.0016 18.3 0.0 2.7 2 0 0 2 2 2 2 DEAD/DEAH box helicase FAINT PF04385.15 AFZ80725.1 - 2.1e-19 69.3 19.6 2.2e-06 27.6 0.8 5.0 4 1 0 4 4 4 4 Domain of unknown function, DUF529 MnmE_helical PF12631.7 AFZ80726.1 - 9.5e-37 127.2 1.1 1.3e-36 126.7 1.1 1.2 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 AFZ80726.1 - 1.2e-30 106.1 0.0 3.3e-30 104.8 0.0 1.8 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 AFZ80726.1 - 6.7e-20 71.3 0.0 1.6e-19 70.1 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AFZ80726.1 - 6.9e-09 35.4 0.0 1.1e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 AFZ80726.1 - 9.7e-05 22.5 0.0 0.00046 20.3 0.0 1.8 1 1 1 2 2 2 1 Dynamin family Roc PF08477.13 AFZ80726.1 - 9.8e-05 22.6 0.0 0.0073 16.5 0.0 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AFZ80726.1 - 0.00052 19.5 0.3 0.15 11.5 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family HU-CCDC81_euk_2 PF18289.1 AFZ80726.1 - 0.001 19.2 0.3 0.1 12.8 0.0 2.9 2 1 1 3 3 2 1 CCDC81 eukaryotic HU domain 2 RsgA_GTPase PF03193.16 AFZ80726.1 - 0.004 17.1 0.0 0.3 11.0 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 AFZ80726.1 - 0.0063 15.9 0.3 0.011 15.1 0.3 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AIG1 PF04548.16 AFZ80726.1 - 0.02 14.2 0.4 0.033 13.5 0.4 1.4 1 0 0 1 1 1 0 AIG1 family Ras PF00071.22 AFZ80726.1 - 0.026 14.1 0.1 0.12 11.9 0.0 2.1 2 0 0 2 2 2 0 Ras family Septin PF00735.18 AFZ80726.1 - 0.032 13.5 0.9 0.73 9.1 0.9 2.2 1 1 0 1 1 1 0 Septin DUF4284 PF14112.6 AFZ80726.1 - 0.11 13.5 0.7 0.26 12.2 0.1 2.0 2 0 0 2 2 2 0 Immunity protein 22 Hus1 PF04005.12 AFZ80727.1 - 7.8e-17 61.3 0.0 8.8e-17 61.1 0.0 1.1 1 0 0 1 1 1 1 Hus1-like protein Sod_Fe_C PF02777.18 AFZ80728.1 - 1.1e-32 112.3 0.5 1.1e-32 112.3 0.5 2.3 2 1 1 3 3 3 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 AFZ80728.1 - 2.9e-16 59.7 8.4 3.2e-12 46.7 0.2 3.2 2 1 1 3 3 3 2 Iron/manganese superoxide dismutases, alpha-hairpin domain FAINT PF04385.15 AFZ80729.1 - 1.6e-06 28.0 0.1 2.1e-06 27.7 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ80730.1 - 1.6e-06 28.0 0.1 2.1e-06 27.7 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function, DUF529 PPR_2 PF13041.6 AFZ80731.1 - 7.5e-35 118.9 16.9 9.9e-11 41.7 0.0 8.7 4 2 6 10 10 10 8 PPR repeat family PPR PF01535.20 AFZ80731.1 - 8.2e-25 85.3 11.4 0.00019 21.4 0.0 8.6 8 0 0 8 8 8 6 PPR repeat PPR_long PF17177.4 AFZ80731.1 - 8.6e-21 74.3 0.0 1.7e-12 47.1 0.0 3.3 1 1 2 3 3 3 3 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 AFZ80731.1 - 2.9e-16 59.3 12.2 0.00014 21.9 0.0 7.2 4 2 5 9 9 9 8 Pentatricopeptide repeat domain PPR_1 PF12854.7 AFZ80731.1 - 1.9e-14 53.0 5.7 0.00099 18.8 0.0 6.3 7 0 0 7 7 7 3 PPR repeat MNE1 PF13762.6 AFZ80731.1 - 0.058 13.4 4.1 0.25 11.3 0.1 3.7 3 2 1 4 4 4 0 Mitochondrial splicing apparatus component IGR PF09597.10 AFZ80731.1 - 0.074 13.2 0.1 0.35 11.0 0.1 2.2 2 0 0 2 2 2 0 IGR protein motif ATP13 PF12921.7 AFZ80731.1 - 0.36 10.7 2.6 1.1 9.2 0.1 2.9 4 1 0 4 4 4 0 Mitochondrial ATPase expression COX6B PF02297.17 AFZ80732.1 - 0.023 14.9 5.5 0.023 14.9 5.5 1.4 2 0 0 2 2 2 0 Cytochrome oxidase c subunit VIb ASXH PF13919.6 AFZ80733.1 - 0.21 11.6 0.1 0.21 11.6 0.1 1.9 2 0 0 2 2 2 0 Asx homology domain Pkinase PF00069.25 AFZ80734.1 - 1.1e-34 120.0 0.2 1.7e-19 70.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ80734.1 - 2.8e-14 53.0 0.0 4.2e-08 32.8 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 AFZ80734.1 - 0.00054 19.4 0.0 0.056 12.8 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 AFZ80734.1 - 0.0013 18.1 0.0 0.0023 17.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 AFZ80734.1 - 0.017 14.7 0.0 0.047 13.2 0.0 1.7 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Histone PF00125.24 AFZ80736.1 - 3.1e-16 59.9 0.1 5.6e-16 59.1 0.1 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 AFZ80736.1 - 3.8e-16 59.1 0.2 5.7e-16 58.5 0.2 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 AFZ80736.1 - 0.031 14.5 0.2 0.074 13.2 0.1 1.6 1 1 1 2 2 2 0 TATA box binding protein associated factor (TAF) Sec63 PF02889.16 AFZ80737.1 - 1.1e-71 241.0 6.3 1.3e-38 132.6 1.9 3.4 3 1 0 3 3 3 2 Sec63 Brl domain DEAD PF00270.29 AFZ80737.1 - 1.6e-52 177.8 0.0 4.1e-27 95.1 0.1 2.6 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 AFZ80737.1 - 1.8e-27 96.4 0.0 1.8e-13 50.8 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 AFZ80737.1 - 6.3e-20 71.6 0.7 3e-08 34.0 0.1 4.3 4 2 0 4 4 4 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 AFZ80737.1 - 4.4e-08 33.5 0.2 0.029 14.7 0.0 3.6 2 2 0 2 2 2 2 AAA domain AAA PF00004.29 AFZ80737.1 - 1.3e-07 32.1 0.3 0.025 15.0 0.3 3.7 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 AFZ80737.1 - 7.6e-06 26.3 0.0 0.035 14.4 0.0 2.8 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.9 AFZ80737.1 - 0.00039 19.8 0.0 0.4 9.9 0.0 2.2 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 AFZ80737.1 - 0.0007 18.7 0.0 0.98 8.4 0.0 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein PhoH PF02562.16 AFZ80737.1 - 0.0026 17.3 0.0 0.87 9.0 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein UvrD-helicase PF00580.21 AFZ80737.1 - 0.0074 15.8 0.6 6.7 6.1 0.0 3.6 4 0 0 4 4 4 1 UvrD/REP helicase N-terminal domain AAA_16 PF13191.6 AFZ80737.1 - 0.025 15.0 0.0 9.1 6.6 0.0 3.0 2 1 0 2 2 2 0 AAA ATPase domain Sad1_UNC PF07738.13 AFZ80738.1 - 2.8e-14 53.3 0.2 9.7e-14 51.5 0.2 2.0 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal DUF1800 PF08811.11 AFZ80738.1 - 0.015 14.3 0.2 0.03 13.3 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1800) PriC PF07445.12 AFZ80738.1 - 0.95 9.4 8.6 7.4 6.5 0.4 2.6 2 0 0 2 2 2 0 Primosomal replication protein priC Ribosomal_L33 PF00471.20 AFZ80739.1 - 3.3e-08 33.8 0.3 1.4e-07 31.9 0.0 2.0 1 1 1 2 2 2 1 Ribosomal protein L33 PAD_porph PF04371.15 AFZ80741.1 - 0.11 11.7 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Porphyromonas-type peptidyl-arginine deiminase FAST_1 PF06743.15 AFZ80741.1 - 0.81 9.7 8.1 0.16 11.9 0.2 3.8 4 0 0 4 4 4 0 FAST kinase-like protein, subdomain 1 RasGEF_N PF00618.20 AFZ80741.1 - 1.2 9.4 9.7 33 4.8 1.4 4.2 2 1 1 3 3 3 0 RasGEF N-terminal motif CLASP_N PF12348.8 AFZ80742.1 - 0.0058 16.2 0.3 0.0095 15.5 0.3 1.4 1 0 0 1 1 1 1 CLASP N terminal Proteasome PF00227.26 AFZ80743.1 - 1.9e-53 180.8 0.3 2.6e-53 180.3 0.3 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AFZ80743.1 - 2.1e-12 46.5 0.0 3.6e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature RAP PF08373.10 AFZ80744.1 - 1.7e-17 63.2 0.1 4.7e-17 61.8 0.1 1.8 1 0 0 1 1 1 1 RAP domain MTES_1575 PF18741.1 AFZ80744.1 - 0.0049 17.0 0.1 0.0049 17.0 0.1 2.3 2 0 0 2 2 2 1 REase_MTES_1575 DUF3669 PF12417.8 AFZ80744.1 - 0.03 14.5 0.0 0.16 12.2 0.0 2.1 2 0 0 2 2 2 0 Zinc finger protein RRM_1 PF00076.22 AFZ80745.1 - 2.9e-15 55.8 0.0 5.2e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF2_hinge PF14327.6 AFZ80745.1 - 0.00093 19.6 0.0 0.0042 17.5 0.0 2.1 2 1 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_7 PF16367.5 AFZ80745.1 - 0.094 12.8 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif LIN52 PF10044.9 AFZ80745.1 - 0.11 13.2 0.0 0.41 11.4 0.0 2.0 1 0 0 1 1 1 0 Retinal tissue protein RST PF12174.8 AFZ80746.1 - 0.023 14.6 0.3 1.5 8.8 0.0 3.8 3 1 1 4 4 4 0 RCD1-SRO-TAF4 (RST) plant domain FAST_1 PF06743.15 AFZ80746.1 - 0.17 11.9 3.3 2.2 8.3 0.0 4.2 4 1 1 5 5 5 0 FAST kinase-like protein, subdomain 1 CAP PF00188.26 AFZ80747.1 - 0.008 17.0 1.0 0.018 15.9 0.0 2.1 2 2 0 2 2 2 1 Cysteine-rich secretory protein family CAP_N PF01213.19 AFZ80747.1 - 0.07 12.6 1.2 0.1 12.1 1.2 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 AFZ80747.1 - 2.5 8.2 7.0 4.4 7.4 7.0 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 FAINT PF04385.15 AFZ80748.1 - 0.0009 19.3 0.0 0.0017 18.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function, DUF529 TSP_1 PF00090.19 AFZ80748.1 - 3.2 8.0 5.0 13 6.1 5.0 2.1 1 0 0 1 1 1 0 Thrombospondin type 1 domain NRN1 PF15056.6 AFZ80749.1 - 3 8.0 6.6 1.9 8.6 0.1 3.9 2 1 1 3 3 3 0 Neuritin protein family zf-CCCH PF00642.24 AFZ80751.1 - 0.0056 16.6 0.9 0.0056 16.6 0.9 3.7 3 1 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 AFZ80751.1 - 2.7 8.2 15.3 0.12 12.5 1.9 3.5 4 0 0 4 4 4 0 Zinc finger domain Hydrolase_4 PF12146.8 AFZ80754.1 - 6.4e-19 68.2 0.0 6.2e-18 64.9 0.0 2.4 2 1 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 AFZ80754.1 - 5.9e-15 55.1 7.5 1.2e-06 28.4 0.3 4.4 3 0 0 3 3 3 2 Domain of unknown function, DUF529 Peptidase_S9 PF00326.21 AFZ80754.1 - 3.7e-05 23.3 0.0 0.00022 20.8 0.0 2.3 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 AFZ80754.1 - 0.0002 22.1 0.0 0.00038 21.1 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 AFZ80754.1 - 0.18 11.6 0.0 0.32 10.8 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 AFZ80754.1 - 0.83 9.2 3.1 0.92 9.1 0.5 2.2 2 1 0 2 2 2 0 alpha/beta hydrolase fold FAINT PF04385.15 AFZ80755.1 - 3e-24 84.9 0.8 6.7e-07 29.3 0.2 3.6 3 0 0 3 3 3 3 Domain of unknown function, DUF529 Glyco_hydro_79C PF16862.5 AFZ80755.1 - 0.044 14.7 0.0 0.17 12.8 0.0 2.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 79 C-terminal beta domain Hydrolase_4 PF12146.8 AFZ80757.1 - 3.2e-21 75.7 0.0 1.6e-20 73.4 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FAINT PF04385.15 AFZ80757.1 - 2.3e-17 62.8 2.3 1.4e-05 25.1 0.6 4.0 3 0 0 3 3 3 3 Domain of unknown function, DUF529 Abhydrolase_1 PF00561.20 AFZ80757.1 - 0.00021 21.0 0.0 0.00054 19.7 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_A6 PF01829.16 AFZ80757.1 - 0.02 14.2 0.0 0.032 13.5 0.0 1.2 1 0 0 1 1 1 0 Peptidase A6 family Abhydrolase_3 PF07859.13 AFZ80757.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold FAINT PF04385.15 AFZ80759.1 - 2.7e-28 97.8 9.1 2.3e-07 30.7 0.2 6.1 6 1 0 6 6 6 5 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ80760.1 - 1.8e-09 37.5 0.0 1e-05 25.5 0.0 2.5 2 1 0 2 2 2 2 Domain of unknown function, DUF529 Hydrolase_4 PF12146.8 AFZ80761.1 - 3.8e-23 82.0 0.0 1.2e-22 80.4 0.0 1.7 2 0 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 AFZ80761.1 - 3.6e-20 71.8 10.0 3.5e-06 27.0 0.9 3.7 3 0 0 3 3 3 3 Domain of unknown function, DUF529 Abhydrolase_1 PF00561.20 AFZ80761.1 - 4e-10 39.8 0.0 5e-08 32.9 0.0 2.6 3 0 0 3 3 3 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AFZ80761.1 - 5.5e-09 36.9 0.0 1.2e-08 35.8 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Say1_Mug180 PF10340.9 AFZ80761.1 - 2.6e-05 23.3 0.4 0.0011 17.9 0.0 2.3 2 0 0 2 2 2 1 Steryl acetyl hydrolase Abhydrolase_4 PF08386.10 AFZ80761.1 - 0.00025 21.1 0.0 0.00056 20.0 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein Palm_thioest PF02089.15 AFZ80761.1 - 0.0064 16.4 0.1 0.019 14.8 0.0 1.8 2 0 0 2 2 2 1 Palmitoyl protein thioesterase Abhydrolase_2 PF02230.16 AFZ80761.1 - 0.0081 16.0 0.2 0.036 13.9 0.0 2.1 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase zf-CCHC PF00098.23 AFZ80762.1 - 1.8e-07 30.9 5.1 0.0038 17.2 0.2 2.3 2 0 0 2 2 2 2 Zinc knuckle Gmx_para_CXXCG PF09535.10 AFZ80762.1 - 0.004 16.4 1.6 0.0056 16.0 1.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (Gmx_para_CXXCG) zf-CCHC_5 PF14787.6 AFZ80762.1 - 0.0041 16.8 6.5 0.28 10.9 1.4 2.4 2 0 0 2 2 2 2 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 AFZ80762.1 - 0.0046 16.7 7.9 0.45 10.4 0.7 2.3 2 0 0 2 2 2 2 Zinc knuckle zinc_ribbon_10 PF10058.9 AFZ80762.1 - 0.016 15.0 2.4 0.032 13.9 2.4 1.5 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-CCHC_4 PF14392.6 AFZ80762.1 - 0.088 12.6 6.5 2.1 8.2 0.6 2.4 2 0 0 2 2 2 0 Zinc knuckle Cas6b_C PF17262.2 AFZ80762.1 - 0.16 12.1 0.6 0.24 11.5 0.6 1.3 1 0 0 1 1 1 0 Cas6b C-terminal domain HypA PF01155.19 AFZ80762.1 - 0.67 10.0 6.1 0.88 9.6 6.1 1.3 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-CCHC_3 PF13917.6 AFZ80762.1 - 1.7 8.7 11.3 4.1 7.4 3.1 2.5 1 1 1 2 2 2 0 Zinc knuckle DUF1163 PF06651.11 AFZ80762.1 - 6.4 6.9 9.3 25 5.0 9.3 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1163) zf-CCHC PF00098.23 AFZ80764.1 - 3.4e-09 36.4 7.6 9.4e-05 22.3 0.3 2.1 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 AFZ80764.1 - 6.2e-05 22.6 2.2 0.19 11.5 0.0 2.1 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 AFZ80764.1 - 0.0059 16.4 0.3 0.0059 16.4 0.3 2.1 2 0 0 2 2 2 1 Zinc knuckle zf-C2H2_10 PF16588.5 AFZ80764.1 - 4.1 7.2 8.9 2.7 7.8 1.1 2.4 2 1 0 2 2 2 0 C2H2 zinc-finger DHHC PF01529.20 AFZ80765.1 - 4.4e-27 94.8 14.0 1e-26 93.6 13.8 1.7 2 0 0 2 2 2 1 DHHC palmitoyltransferase Deltameth_res PF16020.5 AFZ80765.1 - 0.25 11.3 3.2 0.12 12.3 0.3 2.0 2 0 0 2 2 2 0 Deltamethrin resistance Presenilin PF01080.17 AFZ80765.1 - 6.8 5.3 13.2 1.3 7.7 4.2 2.2 2 0 0 2 2 2 0 Presenilin Methyltransf_11 PF08241.12 AFZ80766.1 - 7.1e-14 52.2 0.1 1.9e-13 50.8 0.1 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 AFZ80766.1 - 3.5e-12 46.9 0.1 7.6e-12 45.8 0.1 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 AFZ80766.1 - 2.1e-08 34.2 0.0 3.8e-08 33.3 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AFZ80766.1 - 2.6e-08 33.8 0.1 5.8e-08 32.7 0.0 1.5 1 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 AFZ80766.1 - 2.1e-05 25.2 0.0 3.6e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 AFZ80766.1 - 3.8e-05 23.6 0.1 5.5e-05 23.1 0.1 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase TehB PF03848.14 AFZ80766.1 - 0.0097 15.3 0.1 0.068 12.6 0.1 2.0 1 1 0 1 1 1 1 Tellurite resistance protein TehB Ubie_methyltran PF01209.18 AFZ80766.1 - 0.12 11.7 0.0 0.37 10.1 0.0 1.9 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Ebp2 PF05890.12 AFZ80767.1 - 1e-19 71.2 32.7 1e-19 71.2 32.7 2.7 2 1 1 3 3 3 1 Eukaryotic rRNA processing protein EBP2 Brix PF04427.18 AFZ80768.1 - 3.9e-28 98.9 0.0 5.6e-28 98.4 0.0 1.2 1 0 0 1 1 1 1 Brix domain DUF4637 PF15470.6 AFZ80769.1 - 0.35 10.6 4.8 0.74 9.5 4.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Nop14 PF04147.12 AFZ80769.1 - 1.3 7.2 7.1 1.8 6.7 7.1 1.1 1 0 0 1 1 1 0 Nop14-like family Paf1 PF03985.13 AFZ80769.1 - 8.1 5.3 6.9 14 4.5 6.9 1.3 1 0 0 1 1 1 0 Paf1 Josephin PF02099.17 AFZ80771.1 - 1.7e-16 60.7 0.0 2.7e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 Josephin UBX PF00789.20 AFZ80771.1 - 0.0042 17.3 0.0 0.011 15.9 0.0 1.7 1 0 0 1 1 1 1 UBX domain s48_45 PF07422.13 AFZ80772.1 - 2.3e-06 28.1 2.2 0.00097 19.7 0.1 3.3 3 0 0 3 3 3 2 Sexual stage antigen s48/45 domain FAINT PF04385.15 AFZ80773.1 - 1.1e-14 54.2 4.7 4.4e-10 39.5 0.3 2.8 2 1 1 3 3 3 2 Domain of unknown function, DUF529 CotJB PF12652.7 AFZ80773.1 - 0.061 13.5 0.1 0.2 11.9 0.0 1.8 2 0 0 2 2 2 0 CotJB protein FAINT PF04385.15 AFZ80774.1 - 0.0041 17.1 0.6 0.0085 16.1 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function, DUF529 TIG PF01833.24 AFZ80775.1 - 0.0072 16.4 0.4 0.17 12.0 0.0 3.4 2 0 0 2 2 2 1 IPT/TIG domain EF-hand_7 PF13499.6 AFZ80776.1 - 2.6e-07 31.0 0.2 2.7e-05 24.5 0.2 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 AFZ80776.1 - 1.4e-06 28.0 2.7 0.33 10.8 0.2 4.5 3 2 1 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 AFZ80776.1 - 2.3e-05 24.0 0.7 0.082 12.9 0.1 3.6 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 AFZ80776.1 - 6.4e-05 22.2 3.5 1.1 9.0 0.0 4.2 5 0 0 5 5 5 2 EF hand FAINT PF04385.15 AFZ80777.1 - 1e-07 31.9 3.1 8.3e-05 22.6 0.1 2.9 3 0 0 3 3 3 2 Domain of unknown function, DUF529 McrBC PF10117.9 AFZ80778.1 - 0.00066 18.9 0.2 0.001 18.3 0.2 1.3 1 0 0 1 1 1 1 McrBC 5-methylcytosine restriction system component Sec8_exocyst PF04048.14 AFZ80778.1 - 0.99 9.3 9.0 0.59 10.0 1.0 3.4 1 1 3 4 4 4 0 Sec8 exocyst complex component specific domain HSBP1 PF06825.12 AFZ80780.1 - 0.043 13.7 0.7 0.079 12.8 0.7 1.4 1 0 0 1 1 1 0 Heat shock factor binding protein 1 Cecropin PF00272.19 AFZ80780.1 - 7.4 6.4 9.0 0.22 11.3 0.5 2.4 2 0 0 2 2 2 0 Cecropin family FAINT PF04385.15 AFZ80781.1 - 2.1e-23 82.2 9.6 5e-08 32.9 0.1 5.0 4 0 0 4 4 4 4 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ80782.1 - 2.1e-06 27.7 0.0 3.4e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function, DUF529 DUF908 PF06012.12 AFZ80782.1 - 0.066 12.6 1.9 0.071 12.5 1.9 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Tn7_Tnp_TnsA_N PF08722.11 AFZ80784.1 - 0.11 12.7 2.2 2.5 8.3 2.2 2.4 1 1 0 1 1 1 0 TnsA endonuclease N terminal FAINT PF04385.15 AFZ80787.1 - 0.026 14.6 1.4 0.39 10.8 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function, DUF529 PBECR3 PF18812.1 AFZ80788.1 - 0.022 14.7 1.9 0.044 13.7 0.6 2.0 2 0 0 2 2 2 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease3 Hexokinase_1 PF00349.21 AFZ80789.1 - 2.1e-53 181.2 0.0 2.7e-53 180.8 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 AFZ80789.1 - 3.3e-47 160.9 0.0 4.5e-47 160.5 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Ribosomal_L3 PF00297.22 AFZ80792.1 - 1.4e-168 560.6 3.7 1.6e-168 560.4 3.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 TBPIP PF07106.13 AFZ80793.1 - 0.03 14.2 0.1 0.085 12.8 0.1 1.7 2 0 0 2 2 2 0 TBPIP/Hop2 winged helix domain GATase1_like PF07090.11 AFZ80795.1 - 0.014 14.9 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Putative glutamine amidotransferase Gly-zipper_YMGG PF13441.6 AFZ80795.1 - 0.094 12.5 1.2 0.15 11.8 1.2 1.2 1 0 0 1 1 1 0 YMGG-like Gly-zipper FAINT PF04385.15 AFZ80798.1 - 2.6e-19 69.1 5.7 2.3e-09 37.1 0.0 4.2 4 1 1 5 5 5 3 Domain of unknown function, DUF529 DUF4430 PF14478.6 AFZ80798.1 - 0.083 13.5 0.1 0.2 12.3 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4430) DUF2510 PF10708.9 AFZ80798.1 - 0.25 11.1 0.9 0.67 9.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2510) FAINT PF04385.15 AFZ80800.1 - 3.5e-22 78.3 0.3 8.9e-08 32.1 0.0 4.6 4 0 0 4 4 4 4 Domain of unknown function, DUF529 PKI PF02827.16 AFZ80802.1 - 0.14 12.3 0.5 0.31 11.3 0.5 1.5 1 0 0 1 1 1 0 cAMP-dependent protein kinase inhibitor ENTH PF01417.20 AFZ80803.1 - 8.7e-26 90.4 0.0 1.3e-25 89.9 0.0 1.2 1 0 0 1 1 1 1 ENTH domain CW_7 PF08230.11 AFZ80803.1 - 0.17 11.6 1.1 0.36 10.6 0.0 2.1 2 0 0 2 2 2 0 CW_7 repeat SR-25 PF10500.9 AFZ80803.1 - 0.18 11.4 9.8 0.29 10.7 9.8 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FAINT PF04385.15 AFZ80805.1 - 1.9e-08 34.2 0.9 3.2e-08 33.5 0.9 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 Castor_Poll_mid PF06241.12 AFZ80806.1 - 0.015 15.3 0.1 0.072 13.1 0.0 2.2 3 0 0 3 3 3 0 Castor and Pollux, part of voltage-gated ion channel EMG1 PF03587.14 AFZ80808.1 - 2.1e-28 99.3 0.1 3.3e-28 98.7 0.1 1.3 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase Cys_rich_CPXG PF14255.6 AFZ80811.1 - 0.13 12.2 1.3 0.34 10.8 1.3 1.7 1 0 0 1 1 1 0 Cysteine-rich CPXCG TFIIS_M PF07500.14 AFZ80812.1 - 8.3e-22 77.8 0.4 8.3e-22 77.8 0.4 2.1 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 AFZ80812.1 - 3.6e-17 61.9 6.3 6.8e-17 61.0 6.3 1.5 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 AFZ80812.1 - 3.7e-09 36.5 0.5 1.1e-08 34.9 0.5 1.9 1 0 0 1 1 1 1 TFIIS helical bundle-like domain DUF3770 PF12603.8 AFZ80812.1 - 0.013 15.0 0.1 1.2 8.6 0.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3770) Snapin_Pallidin PF14712.6 AFZ80812.1 - 0.029 14.8 1.1 0.085 13.3 1.1 1.8 1 0 0 1 1 1 0 Snapin/Pallidin Elf1 PF05129.13 AFZ80812.1 - 0.044 13.8 2.1 0.097 12.7 2.1 1.6 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like HBD PF18534.1 AFZ80812.1 - 0.062 13.4 2.3 0.16 12.1 0.1 2.7 3 1 0 3 3 3 0 Helical bundle domain Syntaxin-6_N PF09177.11 AFZ80812.1 - 0.34 11.5 4.7 4.9 7.8 1.7 2.6 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Phage_GP20 PF06810.11 AFZ80812.1 - 1.4 8.7 8.0 1.6 8.6 1.8 3.0 2 1 1 3 3 3 0 Phage minor structural protein GP20 FAINT PF04385.15 AFZ80813.1 - 3.3e-28 97.6 18.4 1.7e-07 31.2 0.2 6.4 6 0 0 6 6 6 6 Domain of unknown function, DUF529 DDE_3 PF13358.6 AFZ80813.1 - 0.12 12.2 0.0 1.2 8.9 0.0 2.2 2 0 0 2 2 2 0 DDE superfamily endonuclease Colicin_D PF11429.8 AFZ80813.1 - 0.12 12.8 0.3 34 5.0 0.1 3.2 3 0 0 3 3 3 0 Colicin D FAINT PF04385.15 AFZ80814.1 - 1e-15 57.5 18.9 1.2e-05 25.2 0.0 5.0 5 0 0 5 5 5 4 Domain of unknown function, DUF529 Tox-SHH PF15652.6 AFZ80814.1 - 0.002 19.0 0.9 0.13 13.3 0.0 2.8 3 0 0 3 3 3 1 HNH/Endo VII superfamily toxin with a SHH signature RHD_dimer PF16179.5 AFZ80814.1 - 0.0073 16.3 4.3 0.67 10.0 0.0 3.6 3 0 0 3 3 3 2 Rel homology dimerisation domain Choline_kinase PF01633.20 AFZ80815.1 - 4.9e-46 157.0 0.0 8.6e-46 156.2 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 AFZ80815.1 - 3.8e-11 43.4 0.0 5.6e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 AFZ80815.1 - 0.00081 18.8 0.0 0.0013 18.1 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase ANAPC4_WD40 PF12894.7 AFZ80819.1 - 1.3e-07 31.8 0.3 0.3 11.4 0.0 4.1 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AFZ80819.1 - 1.8e-07 31.7 8.3 0.00032 21.4 0.0 5.3 6 0 0 6 6 6 2 WD domain, G-beta repeat Frtz PF11768.8 AFZ80819.1 - 0.0013 17.1 0.1 0.016 13.6 0.0 2.1 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz HA2 PF04408.23 AFZ80821.1 - 5.4e-25 87.8 0.0 5.4e-25 87.8 0.0 3.2 2 1 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 AFZ80821.1 - 1.8e-20 73.1 0.0 3.7e-20 72.1 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold S1 PF00575.23 AFZ80821.1 - 1.2e-11 44.7 0.1 3.6e-11 43.3 0.1 1.8 1 0 0 1 1 1 1 S1 RNA binding domain Helicase_C PF00271.31 AFZ80821.1 - 8.5e-11 42.2 0.0 2.9e-10 40.5 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 AFZ80821.1 - 4.6e-06 27.0 0.0 1.7e-05 25.1 0.0 2.0 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 AFZ80821.1 - 0.0026 16.9 0.0 0.0064 15.6 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein DEAD PF00270.29 AFZ80821.1 - 0.0034 17.2 0.0 0.015 15.1 0.0 2.1 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_16 PF13191.6 AFZ80821.1 - 0.021 15.2 0.3 0.11 12.9 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 AFZ80821.1 - 0.16 11.7 0.1 0.61 9.9 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain VESA1_N PF12785.7 AFZ80823.1 - 0.7 8.8 19.7 0.95 8.4 19.7 1.1 1 0 0 1 1 1 0 Variant erythrocyte surface antigen-1 Bax1-I PF01027.20 AFZ80824.1 - 2.5e-14 53.6 33.6 2.9e-14 53.4 33.6 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 SafA PF17073.5 AFZ80824.1 - 0.12 12.3 2.2 0.48 10.4 2.2 2.0 1 0 0 1 1 1 0 Two-component-system connector protein Trypan_PARP PF05887.11 AFZ80825.1 - 0.035 14.1 0.2 0.035 14.1 0.2 3.9 4 1 1 5 5 5 0 Procyclic acidic repetitive protein (PARP) FAINT PF04385.15 AFZ80826.1 - 7.3e-07 29.2 0.1 7.3e-07 29.2 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function, DUF529 Doppel PF11466.8 AFZ80826.1 - 0.86 9.3 2.9 1.6 8.5 2.9 1.3 1 0 0 1 1 1 0 Prion-like protein Doppel ABC_tran PF00005.27 AFZ80827.1 - 2.3e-31 109.1 0.0 2e-17 64.0 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 AFZ80827.1 - 1e-05 25.6 2.7 0.079 12.7 0.0 3.3 4 0 0 4 4 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 AFZ80827.1 - 1.8e-05 24.4 0.6 0.062 13.1 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 AFZ80827.1 - 1.8e-05 25.2 0.0 0.034 14.5 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.6 AFZ80827.1 - 8.1e-05 22.4 0.1 0.068 12.9 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.6 AFZ80827.1 - 8.3e-05 23.2 3.2 0.16 12.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 AFZ80827.1 - 0.00026 20.9 0.6 0.033 14.1 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase Zeta_toxin PF06414.12 AFZ80827.1 - 0.00028 20.2 0.3 0.11 11.8 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin DnaB_C PF03796.15 AFZ80827.1 - 0.0014 18.0 0.0 0.068 12.5 0.0 2.2 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain DUF87 PF01935.17 AFZ80827.1 - 0.0021 18.2 1.8 0.066 13.3 0.1 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain MMR_HSR1 PF01926.23 AFZ80827.1 - 0.0039 17.3 0.2 0.061 13.4 0.1 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_18 PF13238.6 AFZ80827.1 - 0.0044 17.6 0.1 3.7 8.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 AFZ80827.1 - 0.0075 16.2 0.4 3 7.8 0.1 2.6 2 0 0 2 2 2 1 NACHT domain MeaB PF03308.16 AFZ80827.1 - 0.0076 15.3 0.5 0.019 14.0 0.0 1.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB SMC_N PF02463.19 AFZ80827.1 - 0.0081 15.6 1.3 0.23 10.9 0.2 2.6 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain FtsK_SpoIIIE PF01580.18 AFZ80827.1 - 0.0082 15.5 0.4 1.7 7.9 0.0 2.2 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_15 PF13175.6 AFZ80827.1 - 0.0093 15.7 0.3 4.8 6.8 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 AFZ80827.1 - 0.011 16.0 0.0 2.9 8.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 AFZ80827.1 - 0.014 14.6 0.4 0.29 10.3 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain AAA_25 PF13481.6 AFZ80827.1 - 0.033 13.8 0.1 1 8.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 AFZ80827.1 - 0.045 14.0 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit ATPase_2 PF01637.18 AFZ80827.1 - 0.052 13.5 0.1 20 5.0 0.0 3.0 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea T2SSE PF00437.20 AFZ80827.1 - 0.077 12.0 1.0 6.6 5.7 0.1 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein NTPase_1 PF03266.15 AFZ80827.1 - 0.077 12.9 0.3 8.1 6.3 0.1 2.4 2 0 0 2 2 2 0 NTPase TrwB_AAD_bind PF10412.9 AFZ80827.1 - 0.079 11.8 0.3 5.1 5.9 0.1 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain TsaE PF02367.17 AFZ80827.1 - 0.08 13.0 0.4 3.1 7.8 0.1 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Dynamin_N PF00350.23 AFZ80827.1 - 0.089 12.8 0.3 7.6 6.6 0.0 2.5 2 0 0 2 2 2 0 Dynamin family cobW PF02492.19 AFZ80827.1 - 0.095 12.3 3.9 4 7.0 0.0 2.6 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain IstB_IS21 PF01695.17 AFZ80827.1 - 0.11 12.3 0.1 4.9 6.8 0.0 2.8 3 0 0 3 3 2 0 IstB-like ATP binding protein ATP_bind_1 PF03029.17 AFZ80827.1 - 0.14 12.0 0.1 17 5.1 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_33 PF13671.6 AFZ80827.1 - 0.22 11.7 0.1 25 5.0 0.1 2.5 2 0 0 2 2 2 0 AAA domain FAINT PF04385.15 AFZ80828.1 - 2.7e-07 30.6 1.1 0.00024 21.1 0.0 3.2 2 1 0 2 2 2 2 Domain of unknown function, DUF529 DUF3775 PF12616.8 AFZ80828.1 - 0.054 13.5 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3775) A_deaminase PF00962.22 AFZ80829.1 - 1.8e-29 103.1 0.0 2e-29 103.0 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase Antimicrobial_7 PF08102.11 AFZ80829.1 - 0.2 11.9 0.8 11 6.4 0.1 3.1 2 1 1 3 3 3 0 Scorpion antimicrobial peptide FAINT PF04385.15 AFZ80830.1 - 0.039 14.0 0.1 0.069 13.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function, DUF529 hGDE_N PF14699.6 AFZ80830.1 - 0.081 13.1 0.1 0.56 10.4 0.0 2.3 3 0 0 3 3 3 0 N-terminal domain from the human glycogen debranching enzyme FAINT PF04385.15 AFZ80832.1 - 3.4e-22 78.3 3.2 2.2e-05 24.4 0.0 5.0 5 0 0 5 5 5 4 Domain of unknown function, DUF529 DUF1887 PF09002.11 AFZ80832.1 - 0.068 11.8 0.0 0.1 11.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1887) Spt4 PF06093.13 AFZ80833.1 - 4.7e-29 100.3 0.2 6.1e-29 99.9 0.2 1.2 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger GLE1 PF07817.13 AFZ80834.1 - 1.6e-10 40.7 1.5 1e-09 38.0 1.5 2.0 1 1 0 1 1 1 1 GLE1-like protein CDC13_N PF16853.5 AFZ80834.1 - 0.013 15.1 0.3 0.039 13.5 0.3 1.8 1 0 0 1 1 1 0 Cell division control protein 13 N-terminus RasGAP_C PF03836.15 AFZ80834.1 - 2.2 8.4 9.6 2 8.5 5.4 2.6 2 0 0 2 2 2 0 RasGAP C-terminus Hydrolase_3 PF08282.12 AFZ80835.1 - 6.8e-39 134.1 0.0 7.9e-39 133.9 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 AFZ80835.1 - 3.9e-05 23.3 0.0 0.044 13.3 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 AFZ80835.1 - 0.077 13.3 0.0 0.23 11.7 0.0 1.8 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Hydrolase_4 PF12146.8 AFZ80836.1 - 2.4e-22 79.4 0.0 1.2e-21 77.1 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 AFZ80836.1 - 7.6e-07 29.9 0.0 1.4e-06 29.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family FAINT PF04385.15 AFZ80836.1 - 2.7e-06 27.4 7.7 0.11 12.6 0.6 5.0 4 0 0 4 4 4 2 Domain of unknown function, DUF529 Abhydrolase_1 PF00561.20 AFZ80836.1 - 5.4e-05 23.0 0.1 0.00038 20.2 0.1 2.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold LCAT PF02450.15 AFZ80836.1 - 0.0024 17.1 0.0 0.0094 15.2 0.0 2.0 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase LIDHydrolase PF10230.9 AFZ80836.1 - 0.019 14.5 0.1 0.037 13.6 0.1 1.4 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Abhydrolase_4 PF08386.10 AFZ80836.1 - 0.074 13.2 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein DUF900 PF05990.12 AFZ80836.1 - 0.098 12.1 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) PI3_PI4_kinase PF00454.27 AFZ80837.1 - 6.5e-30 104.7 0.1 2e-19 70.4 0.1 2.4 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 AFZ80837.1 - 1.9e-20 73.1 4.4 1.9e-20 73.1 4.4 1.9 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 AFZ80837.1 - 0.028 13.7 0.0 0.052 12.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) Thiolase_N PF00108.23 AFZ80838.1 - 2.4e-34 118.9 0.0 4.3e-34 118.0 0.0 1.4 1 1 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 AFZ80838.1 - 5.9e-18 64.7 0.0 1.2e-17 63.7 0.0 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 AFZ80838.1 - 6.9e-05 22.6 0.0 0.0088 15.9 0.0 2.5 2 0 0 2 2 2 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Bax1-I PF01027.20 AFZ80840.1 - 2.9e-27 95.8 33.8 3.4e-27 95.6 33.8 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF2070 PF09843.9 AFZ80840.1 - 0.47 8.7 25.1 0.63 8.3 25.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF4203 PF13886.6 AFZ80840.1 - 0.8 9.3 29.7 0.097 12.3 24.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4203) Spc7 PF08317.11 AFZ80841.1 - 0.00037 19.5 0.1 0.00037 19.5 0.1 3.2 2 1 1 3 3 3 1 Spc7 kinetochore protein Med9 PF07544.13 AFZ80841.1 - 0.0011 19.0 5.7 5.3 7.2 0.2 5.1 2 1 2 4 4 4 1 RNA polymerase II transcription mediator complex subunit 9 Snapin_Pallidin PF14712.6 AFZ80841.1 - 0.01 16.2 7.1 2.1 8.8 0.0 4.4 3 2 2 5 5 4 0 Snapin/Pallidin CelTOS PF18659.1 AFZ80841.1 - 0.016 15.6 1.0 0.11 12.9 1.0 2.5 1 0 0 1 1 1 0 Cell-traversal protein for ookinetes and sporozoites CREPT PF16566.5 AFZ80841.1 - 0.018 15.2 6.0 0.89 9.7 0.1 3.9 2 1 2 4 4 4 0 Cell-cycle alteration and expression-elevated protein in tumour PI3K_P85_iSH2 PF16454.5 AFZ80841.1 - 0.056 13.0 6.3 0.38 10.4 0.2 3.8 1 1 1 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF3829 PF12889.7 AFZ80841.1 - 0.13 11.8 8.5 1.9 7.9 1.1 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF3829) Helo_like_N PF17111.5 AFZ80841.1 - 0.19 11.1 8.1 0.21 10.9 4.4 2.6 1 1 1 2 2 2 0 Fungal N-terminal domain of STAND proteins EzrA PF06160.12 AFZ80841.1 - 0.23 9.6 12.7 0.0073 14.5 2.6 3.0 2 1 1 3 3 3 0 Septation ring formation regulator, EzrA FlaC_arch PF05377.11 AFZ80841.1 - 0.35 11.3 18.3 2.2 8.7 0.2 7.0 4 1 3 7 7 7 0 Flagella accessory protein C (FlaC) NPV_P10 PF05531.12 AFZ80841.1 - 0.37 11.3 21.6 0.79 10.2 2.0 5.8 3 2 2 6 6 6 0 Nucleopolyhedrovirus P10 protein Filament PF00038.21 AFZ80841.1 - 0.37 10.3 10.0 0.069 12.7 2.9 2.9 1 1 1 2 2 2 0 Intermediate filament protein DUF1664 PF07889.12 AFZ80841.1 - 0.58 10.2 17.0 0.27 11.3 1.7 4.9 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) DUF745 PF05335.13 AFZ80841.1 - 0.62 9.8 4.0 3.2 7.5 0.0 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF745) BLOC1_2 PF10046.9 AFZ80841.1 - 0.75 10.1 11.9 3.7 7.9 0.4 4.9 3 1 2 5 5 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF5082 PF16888.5 AFZ80841.1 - 0.78 10.0 14.7 0.035 14.4 1.6 4.2 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) TRPM_tetra PF16519.5 AFZ80841.1 - 0.88 9.7 5.0 74 3.5 0.1 4.2 3 0 0 3 3 3 0 Tetramerisation domain of TRPM FAM184 PF15665.5 AFZ80841.1 - 1.3 8.7 16.4 0.15 11.8 0.4 4.3 4 1 1 5 5 5 0 Family with sequence similarity 184, A and B Laminin_II PF06009.12 AFZ80841.1 - 5 7.1 15.9 0.4 10.7 0.3 4.6 2 2 2 4 4 4 0 Laminin Domain II Nmad5 PF18757.1 AFZ80841.1 - 7.9 6.6 11.5 12 6.1 1.4 3.5 2 1 1 3 3 3 0 Nucleotide modification associated domain 5 Mod_r PF07200.13 AFZ80841.1 - 8.7 6.4 9.4 18 5.4 1.4 3.4 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein cwf21 PF08312.12 AFZ80843.1 - 7.3e-08 32.4 10.2 7.3e-08 32.4 10.2 2.1 2 0 0 2 2 2 1 cwf21 domain GTP_EFTU PF00009.27 AFZ80844.1 - 1.1e-64 217.6 0.1 1.7e-64 216.9 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 AFZ80844.1 - 5e-31 107.0 0.0 1.9e-30 105.2 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 AFZ80844.1 - 8.7e-22 77.0 0.0 1.9e-21 75.9 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 AFZ80844.1 - 1.4e-14 53.9 0.0 2.8e-14 52.9 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 AFZ80844.1 - 8.9e-13 48.4 0.6 3.1e-12 46.7 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AFZ80844.1 - 0.0013 18.8 0.1 0.0028 17.7 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RF3_C PF16658.5 AFZ80844.1 - 0.032 14.0 0.0 0.063 13.1 0.0 1.5 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain zf-Nse PF11789.8 AFZ80845.1 - 8.5e-14 51.1 2.5 1.5e-13 50.3 2.5 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_2 PF13639.6 AFZ80845.1 - 0.03 14.6 2.9 0.03 14.6 2.9 2.2 3 1 0 3 3 3 0 Ring finger domain zf-RING_UBOX PF13445.6 AFZ80845.1 - 0.084 12.9 1.1 0.18 11.8 1.1 1.6 1 0 0 1 1 1 0 RING-type zinc-finger SIR2 PF02146.17 AFZ80846.1 - 2.6e-28 99.1 0.0 4.1e-28 98.5 0.0 1.3 1 0 0 1 1 1 1 Sir2 family V-SNARE_C PF12352.8 AFZ80847.1 - 2.2e-07 31.0 2.7 5.6e-07 29.8 2.7 1.6 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus DUF1863 PF08937.11 AFZ80847.1 - 0.74 10.1 4.6 0.64 10.3 3.0 1.8 1 1 1 2 2 2 0 MTH538 TIR-like domain (DUF1863) Lebercilin PF15619.6 AFZ80847.1 - 1.1 8.9 11.0 4.1 7.0 10.4 2.0 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease NPV_P10 PF05531.12 AFZ80847.1 - 1.3 9.6 5.7 2.1 8.9 1.2 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.11 AFZ80847.1 - 1.5 9.2 7.1 1.7 8.9 3.4 2.8 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 AFZ80847.1 - 3.1 7.8 9.8 0.24 11.4 1.7 2.3 1 1 1 2 2 2 0 Laminin Domain II Wzz PF02706.15 AFZ80847.1 - 4.4 7.7 6.2 0.9 9.9 1.2 2.4 2 1 1 3 3 3 0 Chain length determinant protein CDC37_N PF03234.14 AFZ80848.1 - 0.00073 20.4 0.7 0.00073 20.4 0.7 1.7 2 0 0 2 2 2 1 Cdc37 N terminal kinase binding Endonuc-HincII PF09226.11 AFZ80848.1 - 0.0024 17.2 1.8 0.0034 16.7 1.8 1.2 1 0 0 1 1 1 1 Restriction endonuclease HincII CF222 PF15661.5 AFZ80850.1 - 0.014 14.4 1.0 0.019 13.9 1.0 1.1 1 0 0 1 1 1 0 C6orf222, uncharacterised family Polysacc_deac_2 PF04748.13 AFZ80850.1 - 0.087 12.0 0.5 1.8 7.7 0.0 2.2 2 0 0 2 2 2 0 Divergent polysaccharide deacetylase Antimicrobial_2 PF08023.12 AFZ80850.1 - 0.2 12.2 4.9 1 9.9 0.2 3.2 3 0 0 3 3 3 0 Frog antimicrobial peptide Elicitin PF00964.17 AFZ80851.1 - 0.0028 17.7 0.6 0.007 16.4 0.6 1.6 1 1 1 2 2 2 1 Elicitin GCV_T PF01571.21 AFZ80852.1 - 0.00063 19.2 0.0 0.047 13.0 0.0 2.1 2 0 0 2 2 2 2 Aminomethyltransferase folate-binding domain LRR_4 PF12799.7 AFZ80853.1 - 5.6e-29 99.7 48.2 2.8e-07 30.8 3.9 5.8 5 1 1 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 AFZ80853.1 - 1.9e-23 82.0 44.1 8.7e-07 28.6 5.2 5.0 3 1 2 5 5 5 4 Leucine rich repeat LRR_9 PF14580.6 AFZ80853.1 - 7e-13 48.4 25.2 1.4e-07 31.2 5.7 3.1 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 AFZ80853.1 - 0.00089 19.5 39.6 7.9 7.5 0.1 10.0 10 1 0 10 10 10 2 Leucine Rich Repeat DUF2322 PF10084.9 AFZ80853.1 - 0.33 11.0 1.8 3.6 7.7 0.1 3.3 3 2 1 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2322) LRR_6 PF13516.6 AFZ80853.1 - 0.41 10.8 40.3 45 4.5 0.2 10.1 10 0 0 10 10 10 0 Leucine Rich repeat FAINT PF04385.15 AFZ80854.1 - 8.2e-13 48.2 5.0 2.7e-06 27.3 1.0 3.9 4 0 0 4 4 4 3 Domain of unknown function, DUF529 DegS PF05384.11 AFZ80854.1 - 0.056 12.9 1.6 0.26 10.8 0.3 2.2 2 0 0 2 2 2 0 Sensor protein DegS AMP-binding PF00501.28 AFZ80856.1 - 7e-65 219.3 0.0 1e-64 218.7 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 AFZ80856.1 - 5.8e-07 30.4 0.1 1.3e-06 29.2 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain CS PF04969.16 AFZ80859.1 - 6.9e-14 52.6 0.1 1.4e-13 51.7 0.0 1.6 2 0 0 2 2 2 1 CS domain Nudc_N PF14050.6 AFZ80859.1 - 1.4e-10 40.9 0.1 2.4e-10 40.2 0.1 1.4 1 0 0 1 1 1 1 N-terminal conserved domain of Nudc. PWWP PF00855.17 AFZ80859.1 - 0.16 12.4 0.4 0.38 11.2 0.4 1.7 1 1 0 1 1 1 0 PWWP domain tRNA-synt_1b PF00579.25 AFZ80860.1 - 2.1e-28 99.5 0.0 3.4e-28 98.8 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) zf-C2HC5 PF06221.13 AFZ80861.1 - 8.2e-10 38.5 9.1 1.3e-09 37.8 9.1 1.3 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type zf-piccolo PF05715.13 AFZ80861.1 - 2.5 8.3 8.8 3.2 8.0 2.2 2.5 1 1 1 2 2 2 0 Piccolo Zn-finger DXP_synthase_N PF13292.6 AFZ80862.1 - 2e-81 273.2 0.0 1.7e-74 250.5 0.0 2.9 2 1 1 3 3 3 2 1-deoxy-D-xylulose-5-phosphate synthase Transket_pyr PF02779.24 AFZ80862.1 - 3.5e-30 105.0 0.0 7.7e-30 103.9 0.0 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 AFZ80862.1 - 1.9e-17 63.3 0.1 3.6e-17 62.4 0.1 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain TPP_enzyme_C PF02775.21 AFZ80862.1 - 0.025 14.4 0.0 0.055 13.3 0.0 1.6 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Transketolase_N PF00456.21 AFZ80862.1 - 0.026 13.5 0.1 0.65 8.9 0.1 2.3 2 0 0 2 2 2 0 Transketolase, thiamine diphosphate binding domain E1_dh PF00676.20 AFZ80862.1 - 0.19 10.7 0.0 0.39 9.6 0.0 1.5 1 0 0 1 1 1 0 Dehydrogenase E1 component Peptidase_M3 PF01432.20 AFZ80863.1 - 9.1e-52 176.8 0.0 1.4e-51 176.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 Ank_2 PF12796.7 AFZ80864.1 - 5.2e-13 49.4 0.6 3.2e-05 24.4 0.1 2.5 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 AFZ80864.1 - 3.2e-09 36.9 0.0 0.0039 17.5 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 AFZ80864.1 - 9e-09 34.9 0.2 0.0048 17.3 0.0 4.6 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.6 AFZ80864.1 - 7.4e-08 32.8 0.5 0.004 17.7 0.0 2.8 1 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 AFZ80864.1 - 1.7e-06 28.2 1.4 0.019 15.4 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_2 PF12796.7 AFZ80865.1 - 3.9e-14 53.0 0.1 7.5e-14 52.1 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 AFZ80865.1 - 7.9e-12 45.5 0.5 2e-06 28.2 0.2 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 AFZ80865.1 - 5e-11 42.5 0.1 0.00051 20.4 0.0 3.6 2 1 1 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 AFZ80865.1 - 6.6e-10 39.1 0.0 1.4e-05 25.2 0.0 3.2 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 AFZ80865.1 - 9.5e-09 34.8 0.0 2.3e-05 24.4 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeat TPR_1 PF00515.28 AFZ80865.1 - 2e-06 27.3 0.0 0.31 11.0 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 AFZ80865.1 - 2.5e-06 27.2 0.0 0.082 13.1 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 AFZ80865.1 - 0.0016 18.0 0.0 3.3 7.5 0.5 2.7 2 0 0 2 2 2 2 TPR repeat TPR_17 PF13431.6 AFZ80865.1 - 0.021 15.2 0.3 1.2 9.6 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat tRNA_anti-codon PF01336.25 AFZ80865.1 - 0.048 13.7 0.1 0.17 11.9 0.1 1.9 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain TPR_8 PF13181.6 AFZ80865.1 - 0.049 13.9 0.8 4.1 7.9 0.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 AFZ80865.1 - 0.14 12.6 0.0 10 6.7 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat RrnaAD PF00398.20 AFZ80868.1 - 8e-24 84.1 0.1 9.4e-24 83.9 0.1 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase TBK1_ULD PF18396.1 AFZ80869.1 - 0.0022 17.9 0.4 0.29 11.1 0.1 2.9 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain DUF2255 PF10012.9 AFZ80869.1 - 0.33 11.1 5.1 13 6.0 0.1 4.1 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2255) RrnaAD PF00398.20 AFZ80870.1 - 2.5e-10 39.9 0.0 3.4e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase MTS PF05175.14 AFZ80870.1 - 0.00025 20.6 0.0 0.0004 20.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 AFZ80870.1 - 0.0031 18.2 0.3 0.015 16.0 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 AFZ80870.1 - 0.0066 16.3 0.0 0.013 15.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AFZ80870.1 - 0.021 15.6 0.0 0.038 14.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.12 AFZ80870.1 - 0.058 12.5 0.0 0.095 11.8 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_33 PF10017.9 AFZ80870.1 - 0.062 12.5 0.0 0.093 11.9 0.0 1.2 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent Methyltransf_2 PF00891.18 AFZ80870.1 - 0.068 12.5 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain FtsJ PF01728.19 AFZ80870.1 - 0.12 12.5 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_32 PF13679.6 AFZ80870.1 - 0.16 11.9 0.1 0.78 9.7 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain WD40 PF00400.32 AFZ80873.1 - 1.8e-19 69.7 9.0 0.0034 18.2 0.0 7.3 6 1 1 7 7 7 5 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 AFZ80873.1 - 2.4e-08 34.3 0.9 4.1e-08 33.5 0.9 1.3 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 AFZ80873.1 - 2.3e-06 27.8 0.0 1.8 8.9 0.0 4.5 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Vps16_N PF04841.13 AFZ80873.1 - 0.0009 18.1 0.0 0.11 11.2 0.0 2.1 2 0 0 2 2 2 2 Vps16, N-terminal region GDI PF00996.18 AFZ80874.1 - 4.5e-27 94.6 0.0 6.3e-20 71.1 0.0 2.8 2 1 0 2 2 2 2 GDP dissociation inhibitor NAD_binding_8 PF13450.6 AFZ80874.1 - 0.00036 20.7 0.0 0.00091 19.4 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain CRM1_repeat_3 PF18787.1 AFZ80874.1 - 0.049 13.7 0.0 0.091 12.9 0.0 1.4 1 0 0 1 1 1 0 CRM1 / Exportin repeat 3 Pyr_redox PF00070.27 AFZ80874.1 - 0.076 13.6 0.0 1.2 9.7 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 AFZ80874.1 - 0.21 10.6 0.0 0.46 9.5 0.0 1.6 2 0 0 2 2 2 0 FAD binding domain SNRNP27 PF08648.12 AFZ80877.1 - 5.7e-27 93.5 1.5 5.7e-27 93.5 1.5 1.9 2 0 0 2 2 2 1 U4/U6.U5 small nuclear ribonucleoproteins FAINT PF04385.15 AFZ80879.1 - 1.7e-08 34.4 6.1 0.062 13.4 0.1 4.3 5 1 0 5 5 5 3 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ80881.1 - 7.7e-06 25.9 1.5 1.2e-05 25.2 1.5 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 EMA PF02488.15 AFZ80881.1 - 0.013 15.2 1.0 0.017 14.8 1.0 1.2 1 0 0 1 1 1 0 Merozoite Antigen SNF2_N PF00176.23 AFZ80882.1 - 7.8e-43 146.5 0.8 9.2e-33 113.4 0.0 2.4 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 AFZ80882.1 - 7.6e-19 68.1 0.0 3.6e-17 62.7 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AFZ80882.1 - 1.8e-10 41.1 1.2 3.1e-10 40.3 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 AFZ80882.1 - 0.00011 22.0 0.0 0.00026 20.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AIF_C PF14721.6 AFZ80882.1 - 3.9 7.9 7.3 20 5.5 4.9 2.8 2 1 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Cpn60_TCP1 PF00118.24 AFZ80883.1 - 5.7e-171 569.4 5.5 6.7e-171 569.2 5.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family SKI PF01202.22 AFZ80883.1 - 0.067 13.3 0.1 0.15 12.2 0.1 1.5 1 0 0 1 1 1 0 Shikimate kinase SAP PF02037.27 AFZ80885.1 - 0.05 13.4 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 SAP domain HTH_47 PF16221.5 AFZ80885.1 - 0.17 11.5 0.1 1.9 8.1 0.1 2.4 2 0 0 2 2 2 0 winged helix-turn-helix Hydrolase_3 PF08282.12 AFZ80888.1 - 1.2e-32 113.7 0.0 1.5e-32 113.4 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 AFZ80888.1 - 3e-07 30.2 0.0 0.0011 18.6 0.0 2.5 3 0 0 3 3 3 2 Sucrose-6F-phosphate phosphohydrolase Tubulin PF00091.25 AFZ80889.1 - 1.2e-10 41.9 0.5 2.8e-10 40.7 0.0 1.8 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain NAGidase PF07555.13 AFZ80889.1 - 0.13 11.6 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 beta-N-acetylglucosaminidase Tubulin_C PF03953.17 AFZ80890.1 - 1.1e-50 171.0 0.5 1.9e-50 170.3 0.1 1.6 2 0 0 2 2 2 1 Tubulin C-terminal domain Tubulin PF00091.25 AFZ80890.1 - 6.5e-48 163.6 0.0 1e-47 162.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.6 AFZ80890.1 - 0.03 14.0 0.0 0.083 12.6 0.0 1.8 1 0 0 1 1 1 0 Tubulin domain Ribosomal_L32e PF01655.18 AFZ80891.1 - 2.9e-45 153.1 1.7 3.4e-45 152.9 1.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 DUF4968 PF16338.5 AFZ80894.1 - 0.22 11.8 1.6 0.86 10.0 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4968) RabGAP-TBC PF00566.18 AFZ80895.1 - 4.6e-18 65.7 0.8 5.1e-18 65.5 0.0 1.4 2 0 0 2 2 2 1 Rab-GTPase-TBC domain FAINT PF04385.15 AFZ80896.1 - 7.7e-06 25.9 1.7 1.6e-05 24.8 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function, DUF529 Adaptin_N PF01602.20 AFZ80897.1 - 5.4e-55 186.9 15.8 6.4e-55 186.7 15.8 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 AFZ80897.1 - 3.3e-10 40.2 8.4 8.6e-09 35.6 0.4 3.2 1 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 AFZ80897.1 - 1.9e-06 27.6 0.8 0.027 14.7 0.0 4.5 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 AFZ80897.1 - 2.2e-05 24.8 0.1 0.016 15.5 0.0 4.0 4 1 0 4 4 4 1 HEAT repeats Vac14_Fab1_bd PF12755.7 AFZ80897.1 - 0.00027 21.5 2.6 0.19 12.4 0.0 3.5 2 1 1 3 3 3 2 Vacuolar 14 Fab1-binding region RasGEF_N_2 PF14663.6 AFZ80897.1 - 0.0025 18.2 11.6 1.1 9.6 0.1 5.1 4 2 1 5 5 5 2 Rapamycin-insensitive companion of mTOR RasGEF_N domain CLASP_N PF12348.8 AFZ80897.1 - 0.0092 15.6 0.5 0.12 11.9 0.1 2.7 2 1 1 3 3 3 1 CLASP N terminal HEAT_EZ PF13513.6 AFZ80897.1 - 0.11 13.0 0.2 82 3.9 0.0 4.1 3 1 1 4 4 4 0 HEAT-like repeat Atx10homo_assoc PF09759.9 AFZ80897.1 - 0.86 9.7 4.4 0.3 11.1 0.2 2.5 3 0 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain SPC22 PF04573.12 AFZ80900.1 - 1.2e-31 109.4 0.0 2.2e-31 108.7 0.0 1.3 1 0 0 1 1 1 1 Signal peptidase subunit Glyco_hydro_3 PF00933.21 AFZ80900.1 - 0.14 11.5 0.0 0.29 10.5 0.0 1.5 1 1 1 2 2 2 0 Glycosyl hydrolase family 3 N terminal domain Prefoldin_2 PF01920.20 AFZ80901.1 - 5.5e-13 48.8 7.5 6.6e-13 48.5 7.5 1.1 1 0 0 1 1 1 1 Prefoldin subunit DUF4553 PF15090.6 AFZ80901.1 - 0.022 13.8 0.6 0.03 13.3 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4553) Sds3 PF08598.11 AFZ80901.1 - 0.072 13.1 4.4 0.086 12.8 4.4 1.2 1 0 0 1 1 1 0 Sds3-like Spc24 PF08286.11 AFZ80901.1 - 0.11 12.7 0.6 0.11 12.7 0.6 2.0 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Mt_ATP-synt_D PF05873.12 AFZ80901.1 - 1.3 8.9 7.5 0.39 10.6 2.7 1.9 1 1 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) Bac_DNA_binding PF00216.21 AFZ80902.1 - 7.1e-21 74.2 0.6 9.6e-21 73.8 0.6 1.2 1 0 0 1 1 1 1 Bacterial DNA-binding protein HU-HIG PF18291.1 AFZ80902.1 - 9.8e-09 35.4 0.3 1.3e-08 35.0 0.3 1.2 1 0 0 1 1 1 1 HU domain fused to wHTH, Ig, or Glycine-rich motif HU-CCDC81_bac_2 PF18175.1 AFZ80902.1 - 0.011 15.5 0.1 0.02 14.7 0.1 1.4 1 0 0 1 1 1 0 CCDC81-like prokaryotic HU domain 2 HU-CCDC81_euk_1 PF14908.6 AFZ80902.1 - 0.057 13.6 0.1 0.085 13.0 0.1 1.4 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 1 BORCS6 PF10157.9 AFZ80902.1 - 0.087 13.1 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 6 FAINT PF04385.15 AFZ80904.1 - 7.7e-14 51.5 3.7 0.0015 18.5 0.6 3.6 3 0 0 3 3 3 3 Domain of unknown function, DUF529 VPS9 PF02204.18 AFZ80905.1 - 0.0032 17.6 0.4 0.014 15.6 0.0 2.3 2 1 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain OGG_N PF07934.12 AFZ80905.1 - 0.048 13.7 1.3 0.092 12.8 0.2 1.9 2 0 0 2 2 2 0 8-oxoguanine DNA glycosylase, N-terminal domain Activator-TraM PF11657.8 AFZ80905.1 - 0.069 13.0 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Transcriptional activator TraM DHH PF01368.20 AFZ80905.1 - 0.21 11.8 1.2 0.6 10.4 1.3 1.6 1 1 0 1 1 1 0 DHH family CTP_transf_like PF01467.26 AFZ80906.1 - 0.0011 19.1 0.0 0.003 17.8 0.0 1.7 1 0 0 1 1 1 1 Cytidylyltransferase-like FAD_syn PF06574.12 AFZ80906.1 - 0.11 12.4 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 FAD synthetase zf-A20 PF01754.16 AFZ80907.1 - 3.7e-11 42.8 11.0 3.7e-11 42.8 11.0 2.8 3 0 0 3 3 3 1 A20-like zinc finger zf-AN1 PF01428.16 AFZ80907.1 - 4.2e-08 33.2 6.1 4.2e-08 33.2 6.1 2.7 2 1 0 2 2 2 1 AN1-like Zinc finger zf-TFIIIC PF12660.7 AFZ80907.1 - 0.93 9.5 8.7 1.9 8.5 0.2 2.7 2 1 0 2 2 2 0 Putative zinc-finger of transcription factor IIIC complex PolC_DP2 PF03833.13 AFZ80907.1 - 2.6 5.8 5.4 3.1 5.5 5.4 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 NdhO PF11910.8 AFZ80908.1 - 0.023 14.9 0.0 0.072 13.3 0.0 1.9 1 0 0 1 1 1 0 Cyanobacterial and plant NDH-1 subunit O DUF5122 PF17164.4 AFZ80908.1 - 0.12 12.7 0.2 0.12 12.7 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5122) beta-propeller WD40 PF00400.32 AFZ80909.1 - 5.9e-12 45.9 1.0 0.0054 17.6 0.0 4.4 5 0 0 5 5 5 3 WD domain, G-beta repeat WD40_like PF17005.5 AFZ80909.1 - 4.6e-05 22.9 6.9 0.044 13.1 1.5 2.4 2 0 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 AFZ80909.1 - 0.024 13.3 0.1 5 5.6 0.0 2.1 2 0 0 2 2 2 0 Nucleoporin Nup120/160 WD40 PF00400.32 AFZ80910.1 - 2.4e-09 37.7 4.3 0.03 15.2 0.0 5.2 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AFZ80910.1 - 0.012 15.9 0.2 0.19 12.0 0.0 2.9 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AFZ80910.1 - 0.03 13.0 0.2 4.5 5.8 0.1 2.5 2 1 0 2 2 2 0 Nucleoporin Nup120/160 zf-RING_2 PF13639.6 AFZ80911.1 - 3.7e-10 40.0 10.5 1.3e-09 38.3 10.5 2.0 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 AFZ80911.1 - 2.8e-06 27.2 6.6 6.1e-06 26.1 6.6 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 AFZ80911.1 - 3.4e-06 26.8 6.1 7.5e-06 25.7 6.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 AFZ80911.1 - 6.8e-06 25.7 4.8 2.9e-05 23.7 4.8 2.2 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 AFZ80911.1 - 0.00014 22.1 7.5 0.00047 20.4 7.5 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 AFZ80911.1 - 0.00017 21.4 9.1 0.0004 20.2 9.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AFZ80911.1 - 0.00058 19.6 8.8 0.00058 19.6 8.8 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 AFZ80911.1 - 0.0024 17.7 7.6 0.0063 16.3 7.6 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 AFZ80911.1 - 0.0079 15.8 6.6 0.021 14.5 6.6 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 AFZ80911.1 - 0.024 14.7 5.1 0.073 13.1 5.1 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-ANAPC11 PF12861.7 AFZ80911.1 - 0.056 13.5 1.9 0.15 12.1 1.9 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 AFZ80911.1 - 0.16 11.9 2.2 0.45 10.4 2.2 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 AFZ80911.1 - 0.91 9.4 7.8 2.6 7.9 7.8 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Hydrolase_4 PF12146.8 AFZ80915.1 - 6.2e-23 81.3 0.0 4.9e-22 78.4 0.0 2.2 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FAINT PF04385.15 AFZ80915.1 - 1.2e-17 63.7 4.1 1.1e-07 31.8 1.1 3.7 3 0 0 3 3 3 3 Domain of unknown function, DUF529 Abhydrolase_1 PF00561.20 AFZ80915.1 - 0.0014 18.4 0.0 0.0032 17.2 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 AFZ80915.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 AFZ80915.1 - 0.11 12.6 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein Abhydrolase_6 PF12697.7 AFZ80915.1 - 0.12 12.9 0.0 0.27 11.8 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase family Pkinase PF00069.25 AFZ80916.1 - 1.7e-60 204.6 0.1 5.4e-34 117.8 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ80916.1 - 3.8e-29 101.7 0.0 1.3e-18 67.3 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 AFZ80916.1 - 1.1e-05 24.9 0.0 2e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 AFZ80916.1 - 0.0024 17.2 0.0 0.2 10.9 0.0 2.7 3 0 0 3 3 3 1 Kinase-like APH PF01636.23 AFZ80916.1 - 0.1 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family UCH PF00443.29 AFZ80918.1 - 1.8e-22 80.1 0.5 3e-22 79.3 0.5 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 AFZ80918.1 - 3.1e-11 43.4 0.0 1.6e-10 41.1 0.0 2.3 1 1 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-UBP_var PF17807.1 AFZ80918.1 - 8.2e-06 25.5 0.0 1.8e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Variant UBP zinc finger UCH_1 PF13423.6 AFZ80918.1 - 0.0024 17.5 0.2 0.018 14.6 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Cwf_Cwc_15 PF04889.12 AFZ80919.1 - 1.3 8.7 22.2 1.6 8.4 22.2 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF4746 PF15928.5 AFZ80919.1 - 1.7 8.0 20.9 2.2 7.6 20.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) MDM1 PF15501.6 AFZ80919.1 - 1.8 7.6 14.1 1.9 7.6 14.1 1.0 1 0 0 1 1 1 0 Nuclear protein MDM1 MFAP1 PF06991.11 AFZ80919.1 - 2.2 8.1 20.5 2.7 7.8 20.5 1.0 1 0 0 1 1 1 0 Microfibril-associated/Pre-mRNA processing DUF4615 PF15393.6 AFZ80919.1 - 2.5 8.7 8.8 3.2 8.3 8.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4615) Serinc PF03348.15 AFZ80919.1 - 4 6.3 5.6 4.7 6.0 5.6 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Afi1 PF07792.12 AFZ80919.1 - 4 7.9 15.3 7.2 7.1 15.3 1.5 1 1 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF2457 PF10446.9 AFZ80919.1 - 5.6 6.0 24.4 6.7 5.7 24.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Tub_N PF16322.5 AFZ80919.1 - 7.2 7.0 19.6 8.9 6.7 19.6 1.2 1 0 0 1 1 1 0 Tubby N-terminal Nop14 PF04147.12 AFZ80919.1 - 7.4 4.6 25.3 8.7 4.4 25.3 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 AFZ80919.1 - 8.8 5.5 24.4 9.8 5.4 24.4 1.1 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 AFZ80919.1 - 10 5.5 29.3 11 5.3 29.3 1.0 1 0 0 1 1 1 0 SDA1 Ribosomal_L1 PF00687.21 AFZ80920.1 - 1.8e-39 135.6 1.7 2.1e-39 135.4 1.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Tnp_22_trimer PF17489.2 AFZ80920.1 - 0.0043 17.0 0.6 0.013 15.5 0.6 1.8 1 0 0 1 1 1 1 L1 transposable element trimerization domain POB3_N PF17292.2 AFZ80921.1 - 1.1e-18 67.5 0.0 1.3e-18 67.2 0.0 1.3 1 0 0 1 1 1 1 POB3-like N-terminal PH domain Rtt106 PF08512.12 AFZ80922.1 - 2.2e-22 79.2 0.2 4.4e-22 78.3 0.2 1.5 1 0 0 1 1 1 1 Histone chaperone Rttp106-like SSrecog PF03531.14 AFZ80922.1 - 6.8e-16 57.9 0.0 8.4e-15 54.4 0.0 2.8 2 0 0 2 2 2 1 Structure-specific recognition protein (SSRP1) LCM PF04072.14 AFZ80923.1 - 5.5e-20 72.1 0.0 1.4e-19 70.8 0.0 1.6 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase Transketolase_N PF00456.21 AFZ80923.1 - 0.11 11.4 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Transketolase, thiamine diphosphate binding domain PUF PF00806.19 AFZ80924.1 - 5e-15 54.2 11.2 1.5e-06 27.5 0.3 7.1 7 0 0 7 7 7 4 Pumilio-family RNA binding repeat Pico_P2B PF01552.17 AFZ80924.1 - 0.043 14.0 0.5 4.7 7.4 0.1 3.1 1 1 1 2 2 2 0 Picornavirus 2B protein DUF4042 PF13251.6 AFZ80924.1 - 0.049 13.3 0.3 0.15 11.8 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4042) BLACT_WH PF17778.1 AFZ80924.1 - 0.11 12.4 0.1 4.6 7.3 0.0 2.5 2 0 0 2 2 2 0 Beta-lactamase associated winged helix domain Fer4_8 PF13183.6 AFZ80924.1 - 1.1 9.7 4.2 2 8.9 1.4 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain Synaptobrevin PF00957.21 AFZ80925.1 - 6.9 6.5 7.0 22 4.9 7.0 1.9 1 0 0 1 1 1 0 Synaptobrevin Abhydrolase_1 PF00561.20 AFZ80926.1 - 2.9e-05 23.9 0.0 0.00035 20.3 0.0 2.3 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 AFZ80926.1 - 0.023 14.0 0.0 0.22 10.7 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 FAINT PF04385.15 AFZ80927.1 - 2.9e-10 40.0 0.0 6.4e-06 26.1 0.0 3.2 2 1 0 2 2 2 2 Domain of unknown function, DUF529 PA26 PF04636.13 AFZ80927.1 - 0.057 12.3 1.6 0.088 11.7 1.6 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) HR1 PF02185.16 AFZ80927.1 - 0.09 12.9 3.0 0.17 12.0 3.0 1.4 1 0 0 1 1 1 0 Hr1 repeat DUF3775 PF12616.8 AFZ80927.1 - 0.13 12.3 0.0 0.4 10.7 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3775) M16C_assoc PF08367.11 AFZ80927.1 - 1.2 8.3 6.2 1.8 7.6 6.2 1.2 1 0 0 1 1 1 0 Peptidase M16C associated RPAP2_Rtr1 PF04181.13 AFZ80927.1 - 1.7 9.0 4.9 0.34 11.3 1.0 1.9 2 0 0 2 2 2 0 Rtr1/RPAP2 family Pkinase PF00069.25 AFZ80929.1 - 3.3e-49 167.6 0.0 4.3e-49 167.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ80929.1 - 3.7e-32 111.6 0.0 1e-31 110.2 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase TF_Zn_Ribbon PF08271.12 AFZ80929.1 - 0.081 12.4 0.2 0.34 10.5 0.1 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding Kdo PF06293.14 AFZ80929.1 - 0.12 11.7 0.1 0.2 11.0 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AFZ80929.1 - 0.16 11.8 0.0 4.7 7.1 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 AFZ80929.1 - 0.19 11.0 0.0 0.29 10.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like C2 PF00168.30 AFZ80930.1 - 3.7e-07 30.4 0.0 0.00023 21.4 0.0 3.2 3 0 0 3 3 3 2 C2 domain GIDA PF01134.22 AFZ80931.1 - 8.3e-138 459.7 0.0 1.1e-137 459.3 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 AFZ80931.1 - 5.4e-45 154.2 0.0 4.4e-44 151.2 0.0 2.2 1 1 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.7 AFZ80931.1 - 4.8e-09 36.1 0.7 8.4e-09 35.3 0.7 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 AFZ80931.1 - 3.8e-06 26.4 0.4 9e-06 25.1 0.4 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 AFZ80931.1 - 1.1e-05 24.8 1.5 0.0035 16.5 0.4 2.3 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_3 PF13738.6 AFZ80931.1 - 0.00013 21.3 0.0 0.014 14.6 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 AFZ80931.1 - 0.00054 20.5 1.1 0.0015 19.1 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 AFZ80931.1 - 0.0073 15.1 3.6 0.48 9.1 0.8 2.9 3 0 0 3 3 3 2 HI0933-like protein AlaDh_PNT_C PF01262.21 AFZ80931.1 - 0.0073 15.6 0.1 0.017 14.5 0.1 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 AFZ80931.1 - 0.1 11.7 0.7 0.39 9.7 0.4 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein DAO PF01266.24 AFZ80931.1 - 0.3 10.6 2.0 6.4 6.3 0.8 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase Trp_halogenase PF04820.14 AFZ80931.1 - 0.92 8.3 3.1 2.7 6.7 0.6 2.0 2 0 0 2 2 2 0 Tryptophan halogenase Thi4 PF01946.17 AFZ80931.1 - 1.1 8.5 3.2 0.95 8.6 0.8 1.9 2 0 0 2 2 2 0 Thi4 family SUI1 PF01253.22 AFZ80932.1 - 1.1e-23 83.6 1.0 1.5e-23 83.1 1.0 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 ssDNA_TraI_N PF18272.1 AFZ80932.1 - 0.016 15.2 0.1 1 9.4 0.0 2.2 2 0 0 2 2 2 0 single-stranded DNA binding TraI N-terminal subdomain Img2 PF05046.14 AFZ80932.1 - 0.1 12.9 0.4 0.14 12.4 0.4 1.3 1 0 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) Snf7 PF03357.21 AFZ80933.1 - 1.2e-23 83.6 19.6 1.9e-23 83.0 19.6 1.3 1 0 0 1 1 1 1 Snf7 BLOC1_2 PF10046.9 AFZ80933.1 - 0.66 10.3 16.9 1.1 9.6 5.8 3.1 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4635 PF15466.6 AFZ80933.1 - 0.82 9.2 6.4 8.3 5.9 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4635) NPV_P10 PF05531.12 AFZ80933.1 - 1.1 9.8 9.8 43 4.7 0.3 3.7 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein SlyX PF04102.12 AFZ80933.1 - 1.2 9.9 0.0 1.2 9.9 0.0 3.5 2 1 1 3 3 3 0 SlyX DUF948 PF06103.11 AFZ80933.1 - 4.9 7.5 6.8 2.9 8.2 0.4 2.8 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Fib_alpha PF08702.10 AFZ80933.1 - 6 7.0 17.0 0.85 9.8 5.4 2.6 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF1899 PF08953.11 AFZ80934.1 - 0.044 13.7 0.0 1.2 9.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1899) FAINT PF04385.15 AFZ80935.1 - 0.00016 21.7 0.2 0.0003 20.8 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ80936.1 - 2.4e-07 30.7 6.4 0.00043 20.3 1.5 2.3 2 0 0 2 2 2 2 Domain of unknown function, DUF529 EMA PF02488.15 AFZ80936.1 - 0.014 15.1 2.7 0.63 9.7 0.1 2.2 1 1 1 2 2 2 0 Merozoite Antigen FAINT PF04385.15 AFZ80937.1 - 1e-15 57.5 3.3 2.1e-06 27.7 0.5 4.8 4 0 0 4 4 4 3 Domain of unknown function, DUF529 EMA PF02488.15 AFZ80937.1 - 0.0015 18.2 0.3 0.005 16.5 0.3 1.9 1 0 0 1 1 1 1 Merozoite Antigen FAINT PF04385.15 AFZ80941.1 - 9.7e-10 38.4 7.1 1.6e-07 31.3 0.7 3.2 3 1 0 3 3 3 2 Domain of unknown function, DUF529 MAGI_u1 PF16663.5 AFZ80941.1 - 0.1 12.7 2.1 0.52 10.4 2.2 2.2 1 1 0 1 1 1 0 Unstructured region on MAGI RNA_pol_3_Rpc31 PF11705.8 AFZ80941.1 - 2.6 8.2 12.3 4.5 7.5 12.3 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Peptidase_M17 PF00883.21 AFZ80942.1 - 7.8e-107 357.1 0.2 9.6e-107 356.8 0.2 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain FAINT PF04385.15 AFZ80943.1 - 4.2e-26 90.8 14.0 5.1e-09 36.1 0.2 5.3 4 2 0 4 4 4 4 Domain of unknown function, DUF529 Tox-SHH PF15652.6 AFZ80943.1 - 0.05 14.6 0.3 0.43 11.6 0.0 2.4 2 0 0 2 2 2 0 HNH/Endo VII superfamily toxin with a SHH signature TcdB_toxin_midN PF12256.8 AFZ80943.1 - 0.075 12.4 0.1 0.17 11.2 0.1 1.5 1 0 0 1 1 1 0 Insecticide toxin TcdB middle/N-terminal region FAINT PF04385.15 AFZ80944.1 - 3.6e-10 39.7 1.0 0.00062 19.8 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function, DUF529 NUT PF12881.7 AFZ80945.1 - 0.86 8.0 2.9 1.3 7.4 2.9 1.2 1 0 0 1 1 1 0 NUT protein PreAtp-grasp PF18604.1 AFZ80946.1 - 0.0081 15.8 0.8 0.024 14.3 0.1 2.0 2 1 0 2 2 2 1 Pre ATP-grasp domain IZUMO PF15005.6 AFZ80946.1 - 0.1 13.1 1.8 0.29 11.6 0.4 2.0 1 1 1 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated OAD_gamma PF04277.13 AFZ80946.1 - 1.2 9.8 4.7 5 7.8 0.8 2.6 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain McyA_C PF12593.8 AFZ80947.1 - 0.2 11.4 0.1 6.1 6.7 0.1 2.5 2 0 0 2 2 2 0 Microcystin synthetase C terminal XPG_I PF00867.18 AFZ80951.1 - 1.1e-23 83.4 0.0 3.7e-23 81.7 0.0 2.0 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.7 AFZ80951.1 - 0.00037 20.0 0.0 0.0008 19.0 0.0 1.6 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.20 AFZ80951.1 - 0.00071 20.1 0.2 0.0047 17.5 0.0 2.4 3 0 0 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold zf-CHCC PF10276.9 AFZ80951.1 - 0.14 12.3 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger domain PGG PF13962.6 AFZ80952.1 - 0.7 9.7 6.7 0.19 11.6 2.8 2.1 2 0 0 2 2 2 0 Domain of unknown function XPG_N PF00752.17 AFZ80953.1 - 0.0012 19.3 0.0 0.0016 18.9 0.0 1.3 1 0 0 1 1 1 1 XPG N-terminal domain DUF2997 PF11211.8 AFZ80953.1 - 0.056 13.2 0.0 0.079 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2997) FAINT PF04385.15 AFZ80954.1 - 1.5e-28 98.7 14.0 6.6e-05 22.9 0.0 7.7 7 0 0 7 7 7 7 Domain of unknown function, DUF529 EMA PF02488.15 AFZ80954.1 - 2.2e-06 27.5 14.3 0.0025 17.5 0.4 5.9 4 2 1 6 6 6 3 Merozoite Antigen MAM PF00629.23 AFZ80954.1 - 0.021 14.8 0.3 0.12 12.3 0.0 2.3 2 0 0 2 2 2 0 MAM domain, meprin/A5/mu zf-CCCH_4 PF18044.1 AFZ80955.1 - 0.00037 20.2 1.7 0.00088 19.0 1.7 1.7 1 0 0 1 1 1 1 CCCH-type zinc finger NUFIP1 PF10453.9 AFZ80955.1 - 0.0017 18.1 2.3 0.0017 18.1 2.3 2.0 2 0 0 2 2 2 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-C2H2_jaz PF12171.8 AFZ80955.1 - 0.028 14.7 1.2 0.092 13.1 1.2 1.9 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf_CCCH_4 PF18345.1 AFZ80955.1 - 0.1 12.7 0.9 0.1 12.7 0.9 2.1 2 0 0 2 2 2 0 Zinc finger domain zf-CCCH PF00642.24 AFZ80955.1 - 0.42 10.6 6.4 0.075 13.0 2.2 2.0 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF5301 PF17225.3 AFZ80956.1 - 0.037 14.5 0.0 0.12 12.9 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5300) FAINT PF04385.15 AFZ80957.1 - 0.095 12.8 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function, DUF529 DUF5540 PF17694.1 AFZ80960.1 - 0.37 11.3 2.3 63 4.2 0.3 3.2 3 0 0 3 3 3 0 Family of unknown function (DUF5540) VSP PF03302.13 AFZ80961.1 - 0.013 14.4 0.1 0.032 13.1 0.1 1.6 1 0 0 1 1 1 0 Giardia variant-specific surface protein Choline_kinase PF01633.20 AFZ80963.1 - 1.1e-28 100.4 0.0 1.5e-28 99.8 0.0 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 AFZ80963.1 - 2.4e-09 37.5 0.1 3.3e-09 37.0 0.1 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Thymosin PF01290.20 AFZ80963.1 - 0.047 13.4 0.0 0.15 11.8 0.0 1.9 1 0 0 1 1 1 0 Thymosin beta-4 family Foamy_BEL PF03274.14 AFZ80963.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Foamy virus BEL 1/2 protein WD40 PF00400.32 AFZ80964.1 - 1.9e-07 31.6 0.6 5.9e-05 23.8 0.0 2.9 3 0 0 3 3 3 2 WD domain, G-beta repeat WD40 PF00400.32 AFZ80966.1 - 1.3e-25 89.1 2.6 6.1e-08 33.2 0.0 4.4 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AFZ80966.1 - 3.2e-09 36.9 0.0 0.018 15.3 0.0 3.3 2 2 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 AFZ80966.1 - 0.00093 18.6 0.0 0.0065 15.8 0.0 2.0 1 1 0 1 1 1 1 WD40-like domain Nucleoporin_N PF08801.11 AFZ80966.1 - 0.001 17.9 0.0 0.57 8.9 0.0 2.1 1 1 1 2 2 2 2 Nup133 N terminal like Ge1_WD40 PF16529.5 AFZ80966.1 - 0.0052 15.8 0.0 0.078 11.9 0.0 2.0 2 0 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 AFZ80966.1 - 0.0098 14.6 0.1 0.028 13.1 0.1 1.7 1 1 0 1 1 1 1 Nucleoporin Nup120/160 FAINT PF04385.15 AFZ80967.1 - 1.8e-11 43.9 0.0 0.0075 16.3 0.0 3.3 3 0 0 3 3 3 3 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ80968.1 - 3.3e-05 23.8 0.6 0.32 11.1 0.4 2.6 2 0 0 2 2 2 2 Domain of unknown function, DUF529 EMA PF02488.15 AFZ80968.1 - 0.0099 15.6 0.8 0.035 13.8 0.1 2.1 2 0 0 2 2 2 1 Merozoite Antigen Frataxin_Cyay PF01491.16 AFZ80968.1 - 0.022 14.8 0.1 0.093 12.8 0.0 1.9 1 1 1 2 2 2 0 Frataxin-like domain ImpA_N PF06812.12 AFZ80969.1 - 0.11 12.6 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 ImpA, N-terminal, type VI secretion system AAA PF00004.29 AFZ80972.1 - 6.3e-42 143.1 0.0 1.2e-41 142.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AFZ80972.1 - 2.2e-11 43.4 2.4 7.7e-11 41.6 0.5 2.3 2 0 0 2 2 2 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 AFZ80972.1 - 6.3e-08 32.5 0.0 1.4e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 AFZ80972.1 - 9.2e-07 29.4 0.0 0.00018 21.9 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 AFZ80972.1 - 2.1e-06 28.0 0.2 4.1e-05 23.8 0.0 2.5 3 0 0 3 3 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 AFZ80972.1 - 4.3e-06 26.8 0.0 8.4e-05 22.6 0.0 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 AFZ80972.1 - 1.3e-05 25.0 0.0 3.1e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 AFZ80972.1 - 0.00051 20.3 0.1 0.021 15.1 0.0 2.6 1 1 1 2 2 2 1 AAA domain RNA_helicase PF00910.22 AFZ80972.1 - 0.0014 19.0 0.0 0.0031 17.9 0.0 1.6 1 0 0 1 1 1 1 RNA helicase DUF815 PF05673.13 AFZ80972.1 - 0.0017 17.6 0.0 0.003 16.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_7 PF12775.7 AFZ80972.1 - 0.0029 17.2 0.0 0.0052 16.3 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region TIP49 PF06068.13 AFZ80972.1 - 0.003 16.8 0.0 0.0063 15.8 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 AFZ80972.1 - 0.0032 17.2 0.1 0.01 15.6 0.0 1.8 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_18 PF13238.6 AFZ80972.1 - 0.0036 17.8 0.0 0.009 16.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 AFZ80972.1 - 0.0054 16.1 0.0 0.011 15.2 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 AFZ80972.1 - 0.0084 16.0 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 AFZ80972.1 - 0.009 16.3 0.0 0.024 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 AFZ80972.1 - 0.012 15.5 0.0 0.087 12.7 0.0 2.1 2 0 0 2 2 2 0 NACHT domain AAA_24 PF13479.6 AFZ80972.1 - 0.017 14.9 0.3 0.043 13.5 0.0 2.0 2 1 0 2 2 1 0 AAA domain AAA_33 PF13671.6 AFZ80972.1 - 0.024 14.8 0.0 0.045 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 AFZ80972.1 - 0.024 14.3 0.0 0.097 12.4 0.0 2.0 2 1 1 3 3 2 0 Sigma-54 interaction domain AAA_14 PF13173.6 AFZ80972.1 - 0.028 14.5 0.0 0.055 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF4200 PF13863.6 AFZ80972.1 - 0.037 14.4 3.3 0.043 14.2 2.1 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF4200) AAA_25 PF13481.6 AFZ80972.1 - 0.043 13.4 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 AFZ80972.1 - 0.055 13.5 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Med4 PF10018.9 AFZ80972.1 - 0.066 12.9 0.5 0.21 11.3 0.1 1.8 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Prot_ATP_OB_N PF17758.1 AFZ80972.1 - 0.066 12.9 0.0 0.19 11.4 0.0 1.7 1 0 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain Parvo_NS1 PF01057.17 AFZ80972.1 - 0.068 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ATPase PF06745.13 AFZ80972.1 - 0.088 12.1 0.1 0.27 10.5 0.0 1.8 2 0 0 2 2 2 0 KaiC AAA_11 PF13086.6 AFZ80972.1 - 0.097 12.4 0.1 0.74 9.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 AFZ80972.1 - 0.11 11.9 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 AFZ80972.1 - 0.11 12.9 0.0 0.6 10.6 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_13 PF13166.6 AFZ80972.1 - 0.16 10.6 0.5 13 4.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain DivIC PF04977.15 AFZ80972.1 - 0.39 10.5 3.3 1.3 8.9 1.8 2.5 3 0 0 3 3 2 0 Septum formation initiator DUF4596 PF15363.6 AFZ80973.1 - 0.14 12.4 0.7 14 6.0 0.3 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4596) HEAT PF02985.22 AFZ80974.1 - 2.8e-08 33.3 7.1 0.002 18.2 0.0 6.6 7 1 1 8 8 8 2 HEAT repeat HEAT_2 PF13646.6 AFZ80974.1 - 1.1e-05 25.7 0.0 0.22 11.9 0.0 6.5 8 1 0 8 8 8 1 HEAT repeats HEAT_EZ PF13513.6 AFZ80974.1 - 0.00011 22.6 0.8 8.7 7.0 0.0 6.4 5 0 0 5 5 5 2 HEAT-like repeat CLASP_N PF12348.8 AFZ80974.1 - 0.0014 18.2 1.2 4 6.9 0.0 5.2 4 1 1 5 5 5 2 CLASP N terminal RTP1_C1 PF10363.9 AFZ80974.1 - 0.022 14.9 2.8 6.6 7.0 0.2 4.8 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 Vac14_Fab1_bd PF12755.7 AFZ80974.1 - 0.28 11.8 10.2 14 6.4 0.1 5.8 5 1 1 6 6 6 0 Vacuolar 14 Fab1-binding region FAINT PF04385.15 AFZ80975.1 - 5e-15 55.3 0.1 3.7e-06 26.9 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 DUF1137 PF06587.11 AFZ80975.1 - 0.13 12.3 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1137) PRA-CH PF01502.18 AFZ80976.1 - 0.04 13.8 0.7 0.8 9.6 0.0 3.4 3 0 0 3 3 3 0 Phosphoribosyl-AMP cyclohydrolase DUF1936 PF09151.10 AFZ80976.1 - 0.077 12.9 0.0 0.28 11.1 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1936) TF_Zn_Ribbon PF08271.12 AFZ80978.1 - 0.3 10.6 1.4 0.66 9.5 1.4 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding Syndecan PF01034.20 AFZ80978.1 - 0.38 10.7 7.2 0.38 10.7 4.8 2.2 1 1 1 2 2 2 0 Syndecan domain FAINT PF04385.15 AFZ80979.1 - 1.2e-05 25.3 0.0 0.01 15.9 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Phage_connect_1 PF05135.13 AFZ80979.1 - 0.0023 18.4 0.0 0.0046 17.4 0.0 1.4 1 0 0 1 1 1 1 Phage gp6-like head-tail connector protein DUF1899 PF08953.11 AFZ80980.1 - 0.54 10.2 2.5 0.44 10.5 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1899) Got1 PF04178.12 AFZ80981.1 - 6.6e-10 39.4 10.4 9.1e-10 39.0 10.4 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family PriX PF18689.1 AFZ80982.1 - 0.03 14.7 0.0 0.056 13.8 0.0 1.5 1 0 0 1 1 1 0 Primase X RR_TM4-6 PF06459.12 AFZ80985.1 - 0.029 14.2 3.7 0.038 13.8 3.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RRN3 PF05327.11 AFZ80985.1 - 0.96 7.9 3.7 1 7.8 3.7 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 NPR3 PF03666.13 AFZ80985.1 - 2 7.1 4.9 2.3 6.9 4.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4637 PF15470.6 AFZ80985.1 - 5.7 6.7 8.1 8.1 6.1 8.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) HARE-HTH PF05066.13 AFZ80986.1 - 0.026 14.9 0.1 2.5 8.6 0.0 2.9 2 0 0 2 2 2 0 HB1, ASXL, restriction endonuclease HTH domain VP4_2 PF08935.10 AFZ80986.1 - 0.11 13.1 0.4 0.34 11.5 0.4 1.8 1 0 0 1 1 1 0 Viral protein VP4 subunit DUF3896 PF13035.6 AFZ80986.1 - 0.25 11.5 3.1 20 5.4 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3896) Dynamin_N PF00350.23 AFZ80986.1 - 0.55 10.3 3.8 0.41 10.7 0.6 2.4 2 1 0 2 2 2 0 Dynamin family FAINT PF04385.15 AFZ80987.1 - 3.5e-05 23.8 0.6 7.8e-05 22.7 0.2 1.8 1 1 1 2 2 2 1 Domain of unknown function, DUF529 PGG PF13962.6 AFZ80988.1 - 0.63 9.9 6.9 0.16 11.8 2.8 2.2 2 0 0 2 2 2 0 Domain of unknown function INCENP_ARK-bind PF03941.15 AFZ80991.1 - 2.7e-05 24.0 0.0 8e-05 22.5 0.0 1.9 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region RBFA PF02033.18 AFZ80993.1 - 7.4e-09 36.0 0.0 1.8e-08 34.8 0.0 1.6 1 0 0 1 1 1 1 Ribosome-binding factor A FAINT PF04385.15 AFZ80994.1 - 1.7e-36 124.1 36.1 6.3e-06 26.2 2.6 9.6 8 1 1 9 9 9 8 Domain of unknown function, DUF529 Hydrolase_4 PF12146.8 AFZ80995.1 - 2.8e-23 82.4 0.1 1.8e-22 79.8 0.0 2.3 2 1 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 AFZ80995.1 - 1.7e-10 40.8 11.1 0.0023 18.0 0.0 5.3 5 1 0 5 5 5 3 Domain of unknown function, DUF529 Abhydrolase_6 PF12697.7 AFZ80995.1 - 3.5e-07 31.1 0.0 8.1e-07 29.9 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 AFZ80995.1 - 0.00018 21.2 1.1 0.0016 18.2 0.8 2.7 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 AFZ80995.1 - 0.022 14.6 0.1 15 5.3 0.0 3.0 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 AFZ80995.1 - 0.029 14.2 0.0 0.099 12.5 0.0 1.8 2 1 0 2 2 2 0 alpha/beta hydrolase fold DUF676 PF05057.14 AFZ80995.1 - 0.035 13.6 0.0 0.078 12.5 0.0 1.5 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_4 PF08386.10 AFZ80995.1 - 0.057 13.5 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein LIDHydrolase PF10230.9 AFZ80995.1 - 0.077 12.5 0.2 0.22 11.0 0.1 1.8 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase ApoC-I PF04691.12 AFZ80997.1 - 0.66 9.9 3.9 0.55 10.2 1.4 2.0 2 0 0 2 2 2 0 Apolipoprotein C-I (ApoC-1) BRCT PF00533.26 AFZ80998.1 - 1.7e-07 31.5 0.3 1.8e-06 28.2 0.2 2.6 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 AFZ80998.1 - 7.7e-06 26.2 0.1 0.00014 22.2 0.0 2.7 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 AFZ80998.1 - 0.0004 20.2 0.0 0.26 11.2 0.0 2.8 2 1 0 2 2 2 2 Regulator of Ty1 transposition protein 107 BRCT domain DUF4598 PF15370.6 AFZ80998.1 - 0.079 13.4 0.0 0.19 12.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4598) MMR_HSR1 PF01926.23 AFZ81001.1 - 5.8e-13 48.9 0.0 1.9e-12 47.2 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AFZ81001.1 - 1e-05 25.1 0.0 3.1e-05 23.6 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B AIG1 PF04548.16 AFZ81001.1 - 0.00032 20.1 0.0 0.0017 17.7 0.0 2.0 2 0 0 2 2 2 1 AIG1 family Dynamin_N PF00350.23 AFZ81001.1 - 0.0036 17.4 0.0 0.5 10.4 0.0 2.9 2 1 0 2 2 2 1 Dynamin family Phage_holin_3_3 PF16083.5 AFZ81002.1 - 0.13 12.4 0.1 0.29 11.3 0.1 1.6 1 0 0 1 1 1 0 LydA holin phage, holin superfamily III TSGP1 PF07771.11 AFZ81002.1 - 1.1 9.4 3.7 10 6.3 0.2 2.9 3 0 0 3 3 3 0 Tick salivary peptide group 1 Arm-DNA-bind_5 PF17293.2 AFZ81003.1 - 0.42 11.1 8.5 1.2 9.6 0.1 3.5 3 0 0 3 3 3 0 Arm DNA-binding domain CooC_C PF15976.5 AFZ81004.1 - 0.078 13.0 0.0 0.21 11.6 0.0 1.7 2 0 0 2 2 2 0 CS1-pili formation C-terminal FAINT PF04385.15 AFZ81005.1 - 1.4e-17 63.5 1.1 4.1e-08 33.2 0.1 3.8 3 2 0 3 3 3 3 Domain of unknown function, DUF529 EMA PF02488.15 AFZ81005.1 - 3.6e-06 26.8 8.2 0.0017 18.1 0.7 2.9 2 1 1 3 3 3 2 Merozoite Antigen FAINT PF04385.15 AFZ81006.1 - 8.3e-12 45.0 7.1 6e-07 29.4 1.9 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 EMA PF02488.15 AFZ81006.1 - 0.0022 17.7 3.0 0.17 11.5 0.1 2.2 1 1 1 2 2 2 2 Merozoite Antigen FAINT PF04385.15 AFZ81007.1 - 3.6e-18 65.4 3.1 5.1e-06 26.5 0.0 3.6 3 1 0 3 3 3 3 Domain of unknown function, DUF529 Ndc1_Nup PF09531.10 AFZ81007.1 - 0.49 9.0 3.5 2.9 6.5 3.7 1.8 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Acetyltransf_1 PF00583.25 AFZ81009.1 - 0.0013 19.0 0.0 0.0013 18.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Ribosomal_S10 PF00338.22 AFZ81010.1 - 2.8e-28 98.0 0.1 3.3e-28 97.8 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e PriA_C PF18074.1 AFZ81010.1 - 0.048 14.5 0.0 0.086 13.7 0.0 1.4 1 0 0 1 1 1 0 Primosomal protein N C-terminal domain IMCp PF12314.8 AFZ81011.1 - 3.7e-29 100.9 57.1 3.4e-27 94.6 38.1 2.5 1 1 1 2 2 2 2 Inner membrane complex protein ComX PF05952.12 AFZ81011.1 - 0.18 11.8 8.9 0.25 11.3 1.1 3.0 2 1 0 2 2 2 0 Bacillus competence pheromone ComX FAINT PF04385.15 AFZ81012.1 - 4.6e-05 23.4 0.1 8.4e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ81013.1 - 5.7e-06 26.3 0.1 8.1e-06 25.8 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ81014.1 - 1.3e-29 102.0 6.6 3.6e-06 26.9 0.3 6.8 6 1 0 6 6 6 6 Domain of unknown function, DUF529 DUF2199 PF09965.9 AFZ81014.1 - 0.0055 16.8 0.8 0.21 11.6 0.0 3.1 3 0 0 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2199) Staphostatin_A PF09022.10 AFZ81014.1 - 0.075 12.9 0.0 0.37 10.7 0.0 2.2 1 0 0 1 1 1 0 Staphostatin A MKT1_C PF12246.8 AFZ81015.1 - 4.3e-37 127.7 0.0 6.1e-37 127.1 0.0 1.2 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 AFZ81015.1 - 5.5e-18 65.1 0.0 1.5e-17 63.7 0.0 1.8 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.17 AFZ81015.1 - 5.7e-05 23.5 0.0 0.00012 22.4 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 AFZ81015.1 - 0.00016 22.0 0.0 0.00038 20.7 0.0 1.7 1 0 0 1 1 1 1 XPG I-region PLD_C PF12357.8 AFZ81015.1 - 0.077 12.9 0.0 0.33 10.9 0.0 2.1 1 0 0 1 1 1 0 Phospholipase D C terminal GTP_EFTU PF00009.27 AFZ81019.1 - 2.7e-39 134.7 0.0 3.8e-39 134.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 AFZ81019.1 - 1.8e-21 75.9 0.0 6.6e-21 74.2 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G C-terminus EFG_IV PF03764.18 AFZ81019.1 - 1.7e-17 63.3 0.0 4e-17 62.1 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.25 AFZ81019.1 - 3.8e-09 36.8 0.0 1e-08 35.4 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFTUD2 PF16004.5 AFZ81019.1 - 4.2e-09 37.0 10.0 9.2e-08 32.7 10.0 2.4 1 1 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_II PF14492.6 AFZ81019.1 - 1.5e-07 31.4 0.0 3.5e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 AFZ81019.1 - 3.4e-05 23.9 0.0 6.6e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 AFZ81019.1 - 0.063 13.5 0.0 18 5.5 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 AFZ81019.1 - 0.08 12.4 0.0 4.8 6.6 0.0 2.3 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Laminin_G_3 PF13385.6 AFZ81020.1 - 2.4e-14 53.8 0.0 3.7e-14 53.1 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 AFZ81020.1 - 3.2e-07 31.0 0.0 6.7e-07 29.9 0.0 1.6 1 1 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 AFZ81020.1 - 5.3e-06 26.7 0.0 1.4e-05 25.3 0.0 1.7 2 0 0 2 2 2 1 Laminin G domain FAINT PF04385.15 AFZ81021.1 - 1.6e-06 28.1 3.7 0.021 14.9 0.4 3.6 3 0 0 3 3 3 3 Domain of unknown function, DUF529 Unstab_antitox PF09720.10 AFZ81023.1 - 0.065 13.3 0.2 0.13 12.3 0.2 1.5 1 0 0 1 1 1 0 Putative addiction module component AvrL567-A PF11529.8 AFZ81023.1 - 0.066 13.4 0.0 0.072 13.3 0.0 1.1 1 0 0 1 1 1 0 Melampsora lini avirulence protein AvrL567-A SRP_SPB PF02978.19 AFZ81023.1 - 0.076 13.6 0.0 0.093 13.4 0.0 1.1 1 0 0 1 1 1 0 Signal peptide binding domain CLP_protease PF00574.23 AFZ81024.1 - 5.9e-70 234.9 0.0 6.9e-70 234.6 0.0 1.0 1 0 0 1 1 1 1 Clp protease DUF496 PF04363.12 AFZ81024.1 - 0.11 12.5 0.5 0.24 11.4 0.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF496) HSP20 PF00011.21 AFZ81025.1 - 1.2e-11 44.6 0.0 1.7e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 AFZ81025.1 - 0.0093 15.5 0.0 0.061 12.9 0.0 2.1 1 1 0 1 1 1 1 HSP20-like domain found in ArsA PBP-Tp47_a PF14889.6 AFZ81026.1 - 0.071 12.7 0.6 0.91 9.1 0.1 2.5 2 0 0 2 2 2 0 Penicillin-binding protein Tp47 domain a Pex14_N PF04695.13 AFZ81026.1 - 1.5 9.4 13.1 0.51 11.0 2.6 2.5 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FAINT PF04385.15 AFZ81031.1 - 9.3e-10 38.4 0.0 9e-06 25.7 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 CCSAP PF15748.5 AFZ81031.1 - 1.1 9.4 46.1 0.24 11.5 24.7 2.2 1 1 1 2 2 2 0 Centriole, cilia and spindle-associated FAINT PF04385.15 AFZ81032.1 - 0.001 19.0 2.1 0.0041 17.2 0.4 2.4 1 1 1 2 2 2 1 Domain of unknown function, DUF529 FAINT PF04385.15 AFZ81033.1 - 2.9e-20 72.1 5.7 5.1e-07 29.7 0.0 5.2 5 0 0 5 5 5 4 Domain of unknown function, DUF529 LPD34 PF18852.1 AFZ81033.1 - 0.13 11.8 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 Large polyvalent protein associated domain 34 Peptidase_C48 PF02902.19 AFZ81034.1 - 1.9e-31 109.6 1.8 1.9e-31 109.6 1.8 1.8 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain AAA_2 PF07724.14 AFZ81035.1 - 5.8e-56 189.3 0.0 8.5e-53 179.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 AFZ81035.1 - 3.8e-33 113.5 3.9 4.6e-33 113.3 0.2 2.9 2 1 1 3 3 2 1 AAA lid domain ClpB_D2-small PF10431.9 AFZ81035.1 - 1.4e-25 89.2 0.1 9.2e-25 86.5 0.1 2.5 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 AFZ81035.1 - 2e-24 86.5 0.0 1.3e-12 48.2 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Clp_N PF02861.20 AFZ81035.1 - 5.4e-20 71.3 0.1 2.2e-12 46.9 0.0 2.8 2 0 0 2 2 2 2 Clp amino terminal domain, pathogenicity island component AAA_5 PF07728.14 AFZ81035.1 - 1.8e-16 60.4 0.1 2e-11 44.0 0.0 3.5 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 AFZ81035.1 - 5.4e-10 39.9 4.1 4.4e-05 23.9 0.1 4.0 3 2 0 4 4 3 2 AAA ATPase domain Sigma54_activat PF00158.26 AFZ81035.1 - 1.1e-08 34.9 0.0 3.4e-06 26.9 0.0 2.7 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_14 PF13173.6 AFZ81035.1 - 1.5e-08 34.8 0.1 0.01 15.8 0.0 3.3 3 0 0 3 3 3 2 AAA domain TniB PF05621.11 AFZ81035.1 - 4.9e-07 29.3 0.3 0.00068 19.1 0.0 3.8 2 2 1 3 3 3 1 Bacterial TniB protein AAA_18 PF13238.6 AFZ81035.1 - 5.8e-07 30.1 0.3 0.063 13.8 0.0 3.8 4 0 0 4 4 3 2 AAA domain IstB_IS21 PF01695.17 AFZ81035.1 - 3.6e-06 26.8 0.0 0.048 13.4 0.0 3.1 3 0 0 3 3 3 2 IstB-like ATP binding protein AAA_22 PF13401.6 AFZ81035.1 - 1.5e-05 25.3 9.8 0.076 13.3 0.1 5.1 5 2 0 5 5 3 2 AAA domain Roc PF08477.13 AFZ81035.1 - 2.8e-05 24.3 0.0 0.17 12.1 0.0 2.7 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase RuvB_N PF05496.12 AFZ81035.1 - 3.9e-05 23.5 2.4 0.33 10.7 0.0 3.9 3 1 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain ATPase_2 PF01637.18 AFZ81035.1 - 4.2e-05 23.6 5.0 1.9 8.4 0.0 5.1 5 1 2 7 7 5 2 ATPase domain predominantly from Archaea AAA_7 PF12775.7 AFZ81035.1 - 5.3e-05 22.8 0.0 0.068 12.7 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region Mg_chelatase PF01078.21 AFZ81035.1 - 0.00013 21.5 0.0 1.6 8.1 0.0 3.4 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI Torsin PF06309.11 AFZ81035.1 - 0.00017 21.7 0.0 0.00072 19.7 0.0 2.0 2 0 0 2 2 1 1 Torsin RsgA_GTPase PF03193.16 AFZ81035.1 - 0.00031 20.7 0.1 1.1 9.1 0.0 3.0 3 0 0 3 3 2 2 RsgA GTPase RNA_helicase PF00910.22 AFZ81035.1 - 0.00031 21.1 0.0 0.35 11.3 0.0 2.9 2 0 0 2 2 2 1 RNA helicase ResIII PF04851.15 AFZ81035.1 - 0.00072 19.6 0.0 0.033 14.2 0.0 2.9 3 0 0 3 3 2 1 Type III restriction enzyme, res subunit TsaE PF02367.17 AFZ81035.1 - 0.00077 19.5 0.0 1 9.4 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 AFZ81035.1 - 0.0011 19.5 1.3 0.071 13.6 0.0 3.4 3 1 0 3 3 2 1 ABC transporter Bac_DnaA PF00308.18 AFZ81035.1 - 0.0013 18.6 0.0 0.7 9.7 0.0 3.2 3 0 0 3 3 3 1 Bacterial dnaA protein NACHT PF05729.12 AFZ81035.1 - 0.0015 18.5 0.0 0.74 9.7 0.0 2.8 2 0 0 2 2 2 1 NACHT domain Zeta_toxin PF06414.12 AFZ81035.1 - 0.0025 17.1 0.0 0.22 10.8 0.0 2.9 2 0 0 2 2 2 1 Zeta toxin AAA_24 PF13479.6 AFZ81035.1 - 0.005 16.6 0.0 3.1 7.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 AFZ81035.1 - 0.0064 16.4 1.6 3.7 7.4 0.0 3.7 4 0 0 4 4 4 1 NTPase AAA_28 PF13521.6 AFZ81035.1 - 0.0087 16.3 0.3 11 6.2 0.0 3.6 4 0 0 4 4 3 0 AAA domain AAA_3 PF07726.11 AFZ81035.1 - 0.0093 15.8 0.0 1.9 8.3 0.0 3.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) betaPIX_CC PF16523.5 AFZ81035.1 - 0.022 14.6 5.0 0.021 14.6 2.7 2.2 2 0 0 2 2 1 0 betaPIX coiled coil AAA_19 PF13245.6 AFZ81035.1 - 0.028 14.8 0.3 2.8 8.3 0.1 3.1 3 1 0 3 3 2 0 AAA domain AFG1_ATPase PF03969.16 AFZ81035.1 - 0.037 12.9 0.1 1 8.2 0.0 2.3 2 0 0 2 2 2 0 AFG1-like ATPase PduV-EutP PF10662.9 AFZ81035.1 - 0.038 13.7 0.0 0.25 11.1 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.6 AFZ81035.1 - 0.049 13.2 0.1 0.36 10.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 AFZ81035.1 - 0.072 13.2 0.0 8.7 6.5 0.0 3.1 3 0 0 3 3 3 0 AAA domain Methyltr_RsmB-F PF01189.17 AFZ81035.1 - 0.086 12.5 0.1 0.2 11.3 0.1 1.6 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F AAA_17 PF13207.6 AFZ81035.1 - 0.12 12.8 0.8 3.1 8.2 0.0 3.4 4 0 0 4 4 2 0 AAA domain Nop16 PF09420.10 AFZ81035.1 - 0.12 12.4 2.3 1.7 8.7 0.0 2.8 3 0 0 3 3 3 0 Ribosome biogenesis protein Nop16 SRP54 PF00448.22 AFZ81035.1 - 0.15 11.7 0.2 5.1 6.7 0.0 2.9 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain PolyA_pol PF01743.20 AFZ81035.1 - 0.29 11.6 1.9 5.6 7.4 0.1 2.8 3 0 0 3 3 2 0 Poly A polymerase head domain KELK PF15796.5 AFZ81035.1 - 0.4 11.2 11.0 0.69 10.4 3.2 3.8 4 0 0 4 4 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF87 PF01935.17 AFZ81035.1 - 1.2 9.2 3.7 4.6 7.3 0.0 3.5 4 1 1 5 5 4 0 Helicase HerA, central domain ABC_tran_CTD PF16326.5 AFZ81035.1 - 3.4 8.0 7.6 0.55 10.5 1.0 3.1 3 0 0 3 3 2 0 ABC transporter C-terminal domain DUF3797 PF12677.7 AFZ81036.1 - 0.017 15.0 0.4 0.046 13.6 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3797) AP2 PF00847.20 AFZ81037.1 - 7.3e-15 54.9 0.0 1.5e-14 53.9 0.0 1.6 1 0 0 1 1 1 1 AP2 domain Glutaredoxin PF00462.24 AFZ81038.1 - 9.1e-15 54.6 0.0 2.2e-14 53.4 0.0 1.7 2 0 0 2 2 2 1 Glutaredoxin tRNA_bind_4 PF18490.1 AFZ81038.1 - 0.041 13.7 0.0 0.062 13.1 0.0 1.3 1 0 0 1 1 1 0 tRNA-binding domain Ribosomal_L7Ae PF01248.26 AFZ81039.1 - 1.9e-16 59.6 0.4 3.3e-16 58.8 0.4 1.5 1 1 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Sulfolobus_pRN PF05584.11 AFZ81039.1 - 0.015 15.3 0.1 0.022 14.8 0.1 1.3 1 0 0 1 1 1 0 Sulfolobus plasmid regulatory protein Ran_BP1 PF00638.18 AFZ81041.1 - 1.7e-37 128.4 0.4 2.7e-37 127.7 0.4 1.3 1 0 0 1 1 1 1 RanBP1 domain Hydrolase_4 PF12146.8 AFZ81042.1 - 6.1e-23 81.3 0.1 4e-22 78.7 0.1 2.2 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 AFZ81042.1 - 1.2e-05 26.0 0.0 3.2e-05 24.6 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family FAINT PF04385.15 AFZ81042.1 - 0.0002 21.3 13.8 0.017 15.2 0.7 4.5 4 1 0 4 4 4 2 Domain of unknown function, DUF529 Abhydrolase_1 PF00561.20 AFZ81042.1 - 0.0016 18.1 0.3 0.015 15.0 0.2 2.7 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 AFZ81042.1 - 0.0084 16.0 0.0 0.027 14.3 0.0 1.9 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 AFZ81042.1 - 0.024 14.5 0.1 12 5.7 0.0 3.0 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Abhydrolase_4 PF08386.10 AFZ81042.1 - 0.053 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein LIDHydrolase PF10230.9 AFZ81042.1 - 0.089 12.3 0.4 0.22 11.0 0.4 1.6 1 1 0 1 1 1 0 Lipid-droplet associated hydrolase Peptidase_S9 PF00326.21 AFZ81042.1 - 0.092 12.2 0.0 20 4.6 0.0 2.7 3 0 0 3 3 3 0 Prolyl oligopeptidase family DUF676 PF05057.14 AFZ81042.1 - 0.11 12.0 0.0 0.26 10.8 0.0 1.5 1 0 0 1 1 1 0 Putative serine esterase (DUF676) MMS1_N PF10433.9 AFZ81043.1 - 1.2e-150 502.5 0.0 2.5e-150 501.4 0.0 1.6 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 AFZ81043.1 - 8.1e-73 245.5 0.0 5.7e-72 242.8 0.0 2.5 4 0 0 4 4 4 1 CPSF A subunit region BBS2_Mid PF14783.6 AFZ81043.1 - 0.0082 16.2 0.2 1.5 8.8 0.0 3.8 4 0 0 4 4 4 1 Ciliary BBSome complex subunit 2, middle region CPW_WPC PF09717.10 AFZ81044.1 - 1.9e-16 60.8 3.5 1.9e-16 60.8 3.5 1.9 2 0 0 2 2 2 1 Plasmodium falciparum domain of unknown function (CPW_WPC) CPW_WPC PF09717.10 AFZ81046.1 - 2.9e-70 233.1 58.1 1e-14 55.2 4.1 7.4 7 0 0 7 7 7 7 Plasmodium falciparum domain of unknown function (CPW_WPC) POTRA_2 PF08479.11 AFZ81047.1 - 0.048 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 POTRA domain, ShlB-type DIX PF00778.17 AFZ81048.1 - 0.069 13.0 0.1 0.3 10.9 0.1 2.1 1 0 0 1 1 1 0 DIX domain RNA_pol_Rpb2_4 PF04566.13 AFZ81049.1 - 0.31 11.3 4.0 0.49 10.7 0.1 2.7 3 1 0 3 3 3 0 RNA polymerase Rpb2, domain 4 Cwf_Cwc_15 PF04889.12 AFZ81049.1 - 0.48 10.1 25.6 0.036 13.8 20.3 1.7 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein CTP_transf_like PF01467.26 AFZ81050.1 - 1.4e-37 129.0 0.0 2e-19 70.2 0.0 2.3 2 0 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 AFZ81050.1 - 3.4e-05 23.8 0.4 0.16 11.8 0.0 3.2 2 1 0 2 2 2 2 FAD synthetase Pantoate_ligase PF02569.15 AFZ81050.1 - 0.01 15.1 0.0 0.12 11.6 0.0 2.3 3 0 0 3 3 3 0 Pantoate-beta-alanine ligase HIGH_NTase1 PF05636.11 AFZ81050.1 - 0.033 13.4 0.1 3.2 6.9 0.0 2.6 3 0 0 3 3 3 0 HIGH Nucleotidyl Transferase SF-assemblin PF06705.11 AFZ81052.1 - 4.3e-39 134.4 22.6 5.7e-39 133.9 22.6 1.1 1 0 0 1 1 1 1 SF-assemblin/beta giardin Baculo_PEP_C PF04513.12 AFZ81052.1 - 0.0021 18.1 14.0 0.011 15.8 4.1 2.7 1 1 1 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1804 PF08822.11 AFZ81052.1 - 0.0079 16.2 0.6 0.02 14.9 0.6 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1804) LPP PF04728.13 AFZ81052.1 - 0.029 14.7 1.8 0.14 12.6 0.4 2.7 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Nmad5 PF18757.1 AFZ81052.1 - 0.056 13.7 7.3 0.34 11.1 7.3 2.2 1 1 0 1 1 1 0 Nucleotide modification associated domain 5 DUF1664 PF07889.12 AFZ81052.1 - 0.095 12.7 16.1 1.8 8.6 2.8 3.5 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) Nup54 PF13874.6 AFZ81052.1 - 0.17 12.0 12.9 0.03 14.4 4.4 2.5 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 HLH PF00010.26 AFZ81052.1 - 0.31 11.0 4.1 0.29 11.1 1.4 2.5 2 0 0 2 2 2 0 Helix-loop-helix DNA-binding domain UPF0184 PF03670.13 AFZ81052.1 - 0.57 10.6 9.3 14 6.2 0.1 4.3 4 1 0 4 4 4 0 Uncharacterised protein family (UPF0184) Exonuc_VII_L PF02601.15 AFZ81052.1 - 2.9 7.4 16.2 2 7.9 6.7 2.1 1 1 1 2 2 2 0 Exonuclease VII, large subunit Prominin PF05478.11 AFZ81052.1 - 3.5 5.5 17.1 2.2 6.1 6.0 2.2 1 1 1 2 2 2 0 Prominin YlqD PF11068.8 AFZ81052.1 - 5.7 7.3 18.2 1.7 9.0 5.0 3.2 1 1 2 3 3 3 0 YlqD protein NPV_P10 PF05531.12 AFZ81052.1 - 9.5 6.8 9.0 5.9e+02 1.0 8.8 3.5 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein WD40 PF00400.32 AFZ81053.1 - 1.6e-09 38.2 2.0 4.2e-06 27.4 0.1 2.9 3 1 0 3 3 3 2 WD domain, G-beta repeat PAP_PilO PF06864.12 AFZ81055.1 - 0.17 10.7 0.1 0.31 9.8 0.1 1.4 1 0 0 1 1 1 0 Pilin accessory protein (PilO) CDC45 PF02724.14 AFZ81055.1 - 0.49 8.6 5.7 0.98 7.6 5.7 1.4 1 0 0 1 1 1 0 CDC45-like protein WD40 PF00400.32 AFZ81056.1 - 7e-05 23.5 6.3 3.4 8.7 0.1 5.2 4 1 1 5 5 5 3 WD domain, G-beta repeat NAP PF00956.18 AFZ81057.1 - 2e-19 69.8 0.0 1.3e-18 67.2 0.0 1.8 1 1 1 2 2 2 1 Nucleosome assembly protein (NAP) WD40 PF00400.32 AFZ81058.1 - 0.00044 21.0 9.9 0.016 16.1 0.0 5.2 6 1 0 6 6 6 2 WD domain, G-beta repeat FAST_1 PF06743.15 AFZ81059.1 - 1.5e-07 31.3 0.1 0.054 13.5 0.0 4.7 3 1 3 6 6 6 2 FAST kinase-like protein, subdomain 1 DUF1844 PF08899.11 AFZ81059.1 - 0.033 14.5 0.6 0.098 13.0 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1844) YojJ PF10372.9 AFZ81059.1 - 0.069 13.3 0.6 18 5.5 0.0 3.3 3 0 0 3 3 3 0 Bacterial membrane-spanning protein N-terminus CLU_N PF15044.6 AFZ81059.1 - 0.084 13.3 0.7 2.3 8.7 0.1 2.4 2 0 0 2 2 2 0 Mitochondrial function, CLU-N-term rpo132 PF12415.8 AFZ81059.1 - 0.25 10.6 1.5 0.39 10.0 0.0 2.1 2 0 0 2 2 2 0 Poxvirus DNA dependent RNA polymerase Methyltransf_11 PF08241.12 AFZ81060.1 - 1.6e-07 31.8 0.0 3.2e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AFZ81060.1 - 1.2e-06 28.4 0.5 1.7e-06 27.9 0.5 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AFZ81060.1 - 3.9e-06 27.5 0.0 8.8e-06 26.3 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 AFZ81060.1 - 0.00075 20.2 0.5 0.0019 18.9 0.1 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 AFZ81060.1 - 0.0031 17.4 0.0 0.0049 16.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Extensin_2 PF04554.13 AFZ81061.1 - 2.5 8.3 11.7 7.2 6.8 11.8 1.7 1 1 0 1 1 1 0 Extensin-like region RseC_MucC PF04246.12 AFZ81061.1 - 7.9 6.4 8.8 0.49 10.4 2.6 2.0 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC HlyIII PF03006.20 AFZ81062.1 - 3.9e-18 66.0 17.0 4.9e-18 65.7 17.0 1.0 1 0 0 1 1 1 1 Haemolysin-III related HEAT_EZ PF13513.6 AFZ81063.1 - 0.0028 18.1 0.0 2.8 8.6 0.0 2.7 2 0 0 2 2 2 2 HEAT-like repeat TMEM72 PF16054.5 AFZ81063.1 - 0.015 15.0 0.0 0.027 14.1 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein family 72 Arm PF00514.23 AFZ81063.1 - 0.021 14.9 3.1 0.16 12.0 0.1 3.4 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat DUF2719 PF10891.8 AFZ81064.1 - 0.0099 15.8 0.0 0.033 14.1 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2719) Rhomboid_N PF12122.8 AFZ81065.1 - 0.0075 16.4 0.1 0.014 15.6 0.1 1.4 1 0 0 1 1 1 1 Cytoplasmic N-terminal domain of rhomboid serine protease Gal11_ABD1 PF18535.1 AFZ81065.1 - 0.062 13.4 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Gal11 activator-binding domain (ABD1) F5_F8_type_C PF00754.25 AFZ81067.1 - 2e-13 50.6 0.6 7.3e-07 29.3 0.1 2.5 2 0 0 2 2 2 2 F5/8 type C domain LCCL PF03815.19 AFZ81067.1 - 2.5e-12 46.8 0.0 2.5e-12 46.8 0.0 2.8 3 0 0 3 3 3 1 LCCL domain Laminin_G_2 PF02210.24 AFZ81067.1 - 0.00026 21.6 0.5 0.0013 19.3 0.2 2.3 2 0 0 2 2 2 1 Laminin G domain Laminin_G_1 PF00054.23 AFZ81067.1 - 0.016 15.4 0.1 0.082 13.1 0.0 2.1 2 0 0 2 2 2 0 Laminin G domain Polysacc_syn_2C PF08485.10 AFZ81067.1 - 0.088 12.5 0.0 0.66 9.7 0.0 2.4 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein C-terminal GNAT_acetyltr_2 PF13718.6 AFZ81067.1 - 0.11 11.9 0.3 0.29 10.5 0.0 1.8 2 0 0 2 2 2 0 GNAT acetyltransferase 2 Tropomyosin_1 PF12718.7 AFZ81067.1 - 0.56 10.4 3.6 19 5.4 0.1 2.8 2 0 0 2 2 2 0 Tropomyosin like DHR10 PF18595.1 AFZ81067.1 - 2.3 8.3 4.8 6.8 6.8 0.9 2.5 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain TMPIT PF07851.13 AFZ81067.1 - 5.1 6.2 5.4 1.5 8.0 1.2 2.1 2 0 0 2 2 2 0 TMPIT-like protein SHE3 PF17078.5 AFZ81068.1 - 0.016 15.0 0.5 0.025 14.3 0.5 1.4 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 zf-H2C2_2 PF13465.6 AFZ81069.1 - 0.029 14.8 0.4 0.065 13.7 0.4 1.5 1 0 0 1 1 1 0 Zinc-finger double domain Imm27 PF15590.6 AFZ81069.1 - 1.9 8.3 5.3 0.35 10.7 0.4 2.5 2 0 0 2 2 2 0 Immunity protein 27 C2 PF00168.30 AFZ81070.1 - 1.3e-09 38.3 0.2 0.0042 17.3 0.0 5.8 5 0 0 5 5 5 2 C2 domain C2-C2_1 PF11618.8 AFZ81070.1 - 0.031 14.4 0.1 39 4.3 0.2 3.3 3 0 0 3 3 3 0 First C2 domain of RPGR-interacting protein 1 DUF4708 PF15813.5 AFZ81070.1 - 0.1 11.7 0.3 0.19 10.9 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4708) Adaptin_N PF01602.20 AFZ81071.1 - 3.9e-85 286.4 15.2 9.4e-82 275.2 9.6 2.0 2 0 0 2 2 2 2 Adaptin N terminal region Cnd1 PF12717.7 AFZ81071.1 - 0.056 13.5 1.2 3.4 7.7 0.2 3.2 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Mst1_SARAH PF11629.8 AFZ81071.1 - 0.07 13.2 0.2 0.19 11.8 0.2 1.7 1 0 0 1 1 1 0 C terminal SARAH domain of Mst1 DUF3310 PF11753.8 AFZ81071.1 - 0.13 12.5 1.5 28 5.0 0.1 3.4 3 0 0 3 3 3 0 Protein of unknwon function (DUF3310) HEAT PF02985.22 AFZ81071.1 - 0.14 12.5 0.0 3.6 8.1 0.0 3.2 2 0 0 2 2 2 0 HEAT repeat STAG PF08514.11 AFZ81072.1 - 1.8e-06 27.8 0.1 1.3e-05 25.1 0.1 2.5 1 0 0 1 1 1 1 STAG domain Ribosomal_L28 PF00830.19 AFZ81073.1 - 0.0013 18.9 0.0 0.003 17.7 0.0 1.6 1 0 0 1 1 1 1 Ribosomal L28 family H_PPase PF03030.16 AFZ81074.1 - 4.6e-26 91.7 26.5 2.1e-12 46.5 5.5 3.0 3 0 0 3 3 3 3 Inorganic H+ pyrophosphatase DUF167 PF02594.16 AFZ81075.1 - 2.7e-24 85.1 0.5 3.3e-24 84.8 0.5 1.1 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 DUF3710 PF12502.8 AFZ81075.1 - 0.12 12.0 0.0 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3710) Thioredoxin PF00085.20 AFZ81076.1 - 3.6e-26 91.1 0.1 4.1e-26 91.0 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 AFZ81076.1 - 1e-06 29.0 0.0 0.00022 21.5 0.0 2.2 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.6 AFZ81076.1 - 3.2e-05 24.3 0.1 0.00022 21.6 0.1 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 AFZ81076.1 - 0.00032 20.6 0.0 0.00036 20.5 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AFZ81076.1 - 0.00057 19.6 0.1 0.0017 18.1 0.1 1.7 1 1 1 2 2 2 1 Redoxin OST3_OST6 PF04756.13 AFZ81076.1 - 0.00069 19.0 0.0 0.0008 18.8 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_9 PF14595.6 AFZ81076.1 - 0.012 15.4 0.0 0.013 15.2 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_7 PF13899.6 AFZ81076.1 - 0.026 14.7 0.1 0.054 13.7 0.1 1.6 1 1 0 1 1 1 0 Thioredoxin-like DSBA PF01323.20 AFZ81076.1 - 0.061 13.1 1.1 4 7.2 0.1 2.1 1 1 1 2 2 2 0 DSBA-like thioredoxin domain TraF PF13728.6 AFZ81076.1 - 0.19 11.5 0.0 0.21 11.4 0.0 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein DotU PF09850.9 AFZ81077.1 - 0.013 15.2 0.0 0.096 12.4 0.0 1.9 2 0 0 2 2 2 0 Type VI secretion system protein DotU HEAT_EZ PF13513.6 AFZ81078.1 - 8.9e-16 58.0 0.8 1.8e-07 31.5 0.0 6.6 5 2 2 7 7 7 4 HEAT-like repeat HEAT PF02985.22 AFZ81078.1 - 5.8e-14 51.0 7.7 0.0029 17.7 0.0 10.0 12 0 0 12 12 12 2 HEAT repeat HEAT_2 PF13646.6 AFZ81078.1 - 1.8e-08 34.7 0.0 0.24 11.8 0.0 5.5 4 2 1 5 5 5 2 HEAT repeats IBN_N PF03810.19 AFZ81078.1 - 2.6e-07 30.5 0.8 5.3e-06 26.2 0.1 3.3 3 0 0 3 3 3 1 Importin-beta N-terminal domain Cnd1 PF12717.7 AFZ81078.1 - 0.00017 21.6 1.9 0.043 13.9 0.0 4.7 4 2 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 AFZ81078.1 - 0.00086 19.3 6.4 0.056 13.5 0.1 5.5 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat Vac14_Fab1_bd PF12755.7 AFZ81078.1 - 0.052 14.1 0.3 16 6.2 0.0 4.2 3 1 2 5 5 5 0 Vacuolar 14 Fab1-binding region AMP-binding PF00501.28 AFZ81079.1 - 6.4e-88 295.2 0.0 7.7e-88 294.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 AFZ81079.1 - 1.2e-20 74.2 0.0 4.2e-20 72.5 0.0 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 AFZ81079.1 - 4.6e-20 71.3 2.2 1.5e-19 69.7 2.2 1.9 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus zf-CCCH_2 PF14608.6 AFZ81080.1 - 6.4e-12 45.5 18.2 8.5e-07 29.2 4.5 2.3 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 AFZ81080.1 - 1.2e-08 34.5 9.4 0.00041 20.1 1.9 2.3 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH PF00642.24 AFZ81080.1 - 5e-08 32.6 7.5 0.0011 18.8 0.9 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 AFZ81080.1 - 4.7e-07 29.7 8.3 0.0021 18.1 1.6 2.5 2 0 0 2 2 2 2 Zinc finger domain zf-CCHH PF10283.9 AFZ81080.1 - 0.0065 16.4 7.0 0.26 11.3 1.4 2.4 2 0 0 2 2 2 2 PBZ domain CART PF06373.11 AFZ81080.1 - 0.097 12.9 1.9 1 9.6 1.9 2.5 1 1 0 1 1 1 0 Cocaine and amphetamine regulated transcript protein (CART) Torus PF16131.5 AFZ81080.1 - 0.13 13.0 4.8 0.23 12.2 0.4 2.7 2 1 1 3 3 3 0 Torus domain Nab2p_Zf1 PF18260.1 AFZ81080.1 - 0.89 9.5 6.1 2.3 8.2 1.6 2.5 2 0 0 2 2 2 0 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 DnaI_N PF07319.11 AFZ81081.1 - 0.04 14.6 0.5 0.15 12.8 0.3 2.0 2 0 0 2 2 2 0 Primosomal protein DnaI N-terminus NepR PF18557.1 AFZ81081.1 - 0.12 12.0 0.2 0.19 11.4 0.2 1.3 1 0 0 1 1 1 0 Anti-sigma factor NepR PQQ PF01011.21 AFZ81083.1 - 0.0034 17.2 0.1 2.3 8.3 0.0 3.8 4 0 0 4 4 4 2 PQQ enzyme repeat Mago_nashi PF02792.14 AFZ81084.1 - 2.6e-69 231.8 0.7 2.9e-69 231.7 0.7 1.0 1 0 0 1 1 1 1 Mago nashi protein DUF2508 PF10704.9 AFZ81085.1 - 0.056 13.6 2.3 2.3 8.5 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) Bromodomain PF00439.25 AFZ81086.1 - 4.7e-18 65.0 0.2 1.2e-17 63.7 0.2 1.8 1 0 0 1 1 1 1 Bromodomain LST1 PF05083.13 AFZ81087.1 - 0.1 12.9 0.3 0.18 12.1 0.3 1.4 1 0 0 1 1 1 0 LST-1 protein WBP-1 PF11669.8 AFZ81087.1 - 0.1 13.2 0.0 0.19 12.4 0.0 1.4 1 0 0 1 1 1 0 WW domain-binding protein 1 MAP17 PF15807.5 AFZ81087.1 - 0.14 12.4 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 MS_channel PF00924.18 AFZ81088.1 - 2.1e-15 56.8 0.7 4.9e-15 55.6 0.7 1.7 1 0 0 1 1 1 1 Mechanosensitive ion channel ADK_lid PF05191.14 AFZ81088.1 - 0.2 11.7 0.1 0.51 10.4 0.1 1.7 1 0 0 1 1 1 0 Adenylate kinase, active site lid Pescadillo_N PF06732.11 AFZ81089.1 - 1e-82 277.8 0.8 1.8e-82 277.0 0.8 1.3 1 0 0 1 1 1 1 Pescadillo N-terminus BRCT_2 PF16589.5 AFZ81089.1 - 3.9e-09 36.8 0.0 9e-09 35.6 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Prefoldin PF02996.17 AFZ81090.1 - 1.4e-12 47.6 0.0 1.8e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 Prefoldin subunit Adeno_E1B_19K PF01691.16 AFZ81090.1 - 0.034 13.7 0.0 0.043 13.3 0.0 1.3 1 0 0 1 1 1 0 Adenovirus E1B 19K protein / small t-antigen Hen1_Lam_C PF18441.1 AFZ81090.1 - 0.11 12.3 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Hen1 La-motif C-terminal domain Rad51 PF08423.11 AFZ81091.1 - 4.7e-116 386.5 0.0 1.8e-115 384.6 0.0 1.7 2 0 0 2 2 2 1 Rad51 RecA PF00154.21 AFZ81091.1 - 9.5e-10 38.4 0.0 1.4e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 AFZ81091.1 - 4.6e-06 26.4 0.0 9.9e-06 25.3 0.0 1.5 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 AFZ81091.1 - 0.00046 19.6 1.0 0.0018 17.7 1.0 2.0 1 1 0 1 1 1 1 KaiC AAA_24 PF13479.6 AFZ81091.1 - 0.013 15.3 0.0 0.021 14.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 AFZ81091.1 - 0.017 15.4 0.0 0.032 14.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain zf-NF-X1 PF01422.17 AFZ81091.1 - 2.1 8.5 4.1 1.6 8.9 0.8 2.4 2 0 0 2 2 2 0 NF-X1 type zinc finger MS_channel PF00924.18 AFZ81092.1 - 2.8e-07 30.3 2.6 2.8e-07 30.3 2.6 2.1 2 0 0 2 2 2 1 Mechanosensitive ion channel Med26 PF08711.11 AFZ81094.1 - 1.8e-07 31.1 1.0 1.3e-06 28.4 0.0 2.5 2 0 0 2 2 2 1 TFIIS helical bundle-like domain H2TH PF06831.14 AFZ81094.1 - 0.049 13.6 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Formamidopyrimidine-DNA glycosylase H2TH domain SNURF PF07192.11 AFZ81094.1 - 0.066 13.1 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 SNURF/RPN4 protein Adaptin_binding PF10199.9 AFZ81094.1 - 4.9 7.8 8.6 0.47 11.1 3.8 1.7 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 Nucleoporin_FG PF13634.6 AFZ81095.1 - 0.00022 22.0 60.6 0.11 13.4 31.2 3.0 1 1 1 2 2 2 2 Nucleoporin FG repeat region DnaJ PF00226.31 AFZ81096.1 - 5.2e-19 68.1 2.8 5.2e-19 68.1 2.8 2.6 2 1 0 2 2 2 1 DnaJ domain TINF2_N PF14973.6 AFZ81096.1 - 0.13 12.6 2.0 0.45 10.9 0.4 2.0 2 0 0 2 2 2 0 TERF1-interacting nuclear factor 2 N-terminus S_4TM PF18159.1 AFZ81096.1 - 0.25 10.6 1.5 0.92 8.7 0.1 2.1 2 0 0 2 2 2 0 SMODS-associating 4TM effector domain JAB PF01398.21 AFZ81097.1 - 1.5e-29 102.4 0.0 1.1e-28 99.6 0.0 2.0 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 AFZ81097.1 - 7.3e-27 94.0 0.2 1.1e-26 93.4 0.2 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function DUF2423 PF10338.9 AFZ81098.1 - 2.7e-07 30.7 0.9 4.5e-07 30.0 0.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2423) Ribosomal_L36e PF01158.18 AFZ81099.1 - 1.7e-33 114.7 0.3 2.1e-33 114.4 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L36e Bystin PF05291.11 AFZ81100.1 - 5.6e-98 327.8 1.0 8.5e-98 327.2 1.0 1.2 1 0 0 1 1 1 1 Bystin Glycos_transf_2 PF00535.26 AFZ81102.1 - 0.085 12.7 0.1 0.49 10.2 0.0 2.2 2 1 1 3 3 3 0 Glycosyl transferase family 2 Rootletin PF15035.6 AFZ81102.1 - 0.68 9.9 6.6 0.15 12.1 2.2 2.0 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion MIF4G PF02854.19 AFZ81103.1 - 8.4e-26 90.9 3.1 8.4e-26 90.9 3.1 1.7 2 0 0 2 2 2 1 MIF4G domain PAM2 PF07145.15 AFZ81103.1 - 3.7e-06 26.2 8.4 0.019 14.6 0.0 2.8 3 0 0 3 3 3 2 Ataxin-2 C-terminal region MA3 PF02847.17 AFZ81103.1 - 0.054 13.5 0.5 0.19 11.7 0.5 2.0 1 0 0 1 1 1 0 MA3 domain RF-1 PF00472.20 AFZ81104.1 - 1.5e-27 95.8 4.4 2.2e-27 95.3 4.4 1.2 1 0 0 1 1 1 1 RF-1 domain PCRF PF03462.18 AFZ81104.1 - 1.5e-24 86.9 2.1 4e-24 85.6 0.1 2.4 2 1 0 2 2 2 1 PCRF domain MIR PF02815.19 AFZ81104.1 - 0.0062 16.4 0.3 0.0097 15.8 0.3 1.3 1 0 0 1 1 1 1 MIR domain Acid_PPase PF12689.7 AFZ81105.1 - 0.00082 19.3 0.0 0.0028 17.5 0.0 1.8 2 0 0 2 2 2 1 Acid Phosphatase HAD_2 PF13419.6 AFZ81105.1 - 0.0033 17.5 0.0 1.1 9.3 0.0 2.5 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase zf-primase PF09329.11 AFZ81106.1 - 9.5e-09 34.9 1.0 9.5e-09 34.9 1.0 2.3 2 0 0 2 2 2 1 Primase zinc finger Mcm10 PF09332.11 AFZ81106.1 - 0.0063 16.0 9.4 0.0063 16.0 9.4 2.0 2 0 0 2 2 2 1 Mcm10 replication factor FYDLN_acid PF09538.10 AFZ81106.1 - 0.05 14.3 1.2 0.05 14.3 1.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Cys_rich_KTR PF14205.6 AFZ81106.1 - 2.4 8.0 6.2 1.7 8.5 2.8 2.5 1 1 1 2 2 2 0 Cysteine-rich KTR zf_CopZ PF18423.1 AFZ81106.1 - 3.8 7.5 9.7 0.2 11.6 1.7 2.9 2 1 1 3 3 3 0 Zinc binding domain NUC153 PF08159.12 AFZ81108.1 - 1.6e-05 24.6 1.2 0.00011 21.9 1.2 2.2 1 1 0 1 1 1 1 NUC153 domain ANAPC4_WD40 PF12894.7 AFZ81108.1 - 5.7e-05 23.3 0.8 0.0036 17.5 0.1 2.9 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AFZ81108.1 - 0.0051 17.6 1.4 8 7.5 0.0 5.0 6 0 0 6 6 6 1 WD domain, G-beta repeat RabGAP-TBC PF00566.18 AFZ81109.1 - 1.8e-27 96.4 15.5 2e-13 50.5 7.2 2.7 1 1 1 2 2 2 2 Rab-GTPase-TBC domain Syntaxin-18_N PF10496.9 AFZ81109.1 - 0.015 15.5 1.7 11 6.4 0.1 3.4 3 0 0 3 3 3 0 SNARE-complex protein Syntaxin-18 N-terminus FKBP_C PF00254.28 AFZ81110.1 - 0.011 16.1 0.0 0.019 15.3 0.0 1.4 1 1 0 1 1 1 0 FKBP-type peptidyl-prolyl cis-trans isomerase GreA_GreB PF01272.19 AFZ81110.1 - 0.13 12.2 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Transcription elongation factor, GreA/GreB, C-term Sec1 PF00995.23 AFZ81111.1 - 3.8e-101 340.1 21.0 4.4e-101 339.9 21.0 1.0 1 0 0 1 1 1 1 Sec1 family DUF3369 PF11849.8 AFZ81111.1 - 0.066 13.4 1.0 0.17 12.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3369) EF_TS PF00889.19 AFZ81112.1 - 7.5e-27 94.3 2.2 2.2e-14 53.6 1.1 2.2 2 0 0 2 2 2 2 Elongation factor TS Lip_prot_lig_C PF10437.9 AFZ81112.1 - 0.043 13.8 0.6 5.6 7.0 0.1 2.5 2 0 0 2 2 2 0 Bacterial lipoate protein ligase C-terminus TetR_C_8 PF14278.6 AFZ81112.1 - 0.1 12.7 1.1 11 6.2 0.0 2.7 2 0 0 2 2 2 0 Transcriptional regulator C-terminal region DUF445 PF04286.12 AFZ81112.1 - 0.2 11.4 2.5 0.85 9.4 2.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF445) Thioredoxin PF00085.20 AFZ81113.1 - 2.7e-05 24.1 0.1 4.1e-05 23.5 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 AFZ81113.1 - 0.065 13.6 0.8 0.51 10.7 0.8 2.2 1 1 0 1 1 1 0 Thioredoxin-like AMMECR1 PF01871.17 AFZ81115.1 - 8.7e-45 152.3 0.0 1e-44 152.1 0.0 1.0 1 0 0 1 1 1 1 AMMECR1 RRN3 PF05327.11 AFZ81116.1 - 1.1e-57 195.9 10.7 1.1e-57 195.9 10.7 1.5 2 0 0 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 DUF3223 PF11523.8 AFZ81116.1 - 4.5e-12 46.6 0.1 1.4e-11 45.1 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3223) Rad51 PF08423.11 AFZ81117.1 - 1.9e-05 24.1 0.1 3.7e-05 23.1 0.1 1.5 1 1 0 1 1 1 1 Rad51 CENP-C_C PF11699.8 AFZ81118.1 - 0.0061 16.8 0.9 0.021 15.0 0.9 1.9 1 0 0 1 1 1 1 Mif2/CENP-C like CAF1 PF04857.20 AFZ81119.1 - 3.1e-51 174.5 0.3 8.8e-26 90.8 0.1 2.0 1 1 1 2 2 2 2 CAF1 family ribonuclease PUF PF00806.19 AFZ81120.1 - 5.2e-55 180.1 12.8 1.4e-08 33.9 0.0 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat WD40 PF00400.32 AFZ81121.1 - 7.1e-28 96.3 15.7 2.9e-07 31.1 3.1 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AFZ81121.1 - 4.7e-09 36.4 2.2 0.00061 20.0 0.1 4.5 2 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 AFZ81121.1 - 0.0012 18.2 0.0 0.56 9.5 0.0 2.5 2 0 0 2 2 2 2 WD40-like domain TFIIIC_delta PF12657.7 AFZ81121.1 - 0.0017 18.4 1.3 1 9.3 0.1 2.6 2 0 0 2 2 2 2 Transcription factor IIIC subunit delta N-term Ge1_WD40 PF16529.5 AFZ81121.1 - 0.03 13.3 0.3 0.18 10.7 0.2 2.3 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein CHASE8 PF17152.4 AFZ81121.1 - 0.11 12.7 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 Periplasmic sensor domain DEAD PF00270.29 AFZ81122.1 - 5e-47 159.9 0.0 1.8e-45 154.8 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AFZ81122.1 - 5.5e-30 104.0 0.0 2.1e-29 102.1 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Ribosomal_S24e PF01282.19 AFZ81123.1 - 1.4e-28 98.6 0.0 2.6e-28 97.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S24e SAP30_Sin3_bdg PF13867.6 AFZ81123.1 - 0.0051 17.1 0.4 0.05 13.9 0.1 2.3 2 0 0 2 2 2 1 Sin3 binding region of histone deacetylase complex subunit SAP30 UbiA PF01040.18 AFZ81124.1 - 3.7e-42 144.4 8.3 4.8e-42 144.0 8.3 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family eIF2A PF08662.11 AFZ81125.1 - 5.3e-28 98.2 0.1 1.3e-21 77.4 1.4 4.4 3 2 0 3 3 3 3 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 AFZ81125.1 - 0.0042 16.9 0.0 0.013 15.3 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.32 AFZ81125.1 - 0.012 16.4 0.3 65 4.6 0.0 4.8 4 1 1 5 5 5 0 WD domain, G-beta repeat DivIC PF04977.15 AFZ81125.1 - 0.41 10.4 2.0 0.88 9.4 2.0 1.5 1 0 0 1 1 1 0 Septum formation initiator p25-alpha PF05517.12 AFZ81126.1 - 4.3e-10 40.0 0.1 6.6e-10 39.4 0.1 1.4 1 0 0 1 1 1 1 p25-alpha DCX PF03607.17 AFZ81126.1 - 8.4e-06 25.8 0.0 1.7e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Doublecortin AP2 PF00847.20 AFZ81127.1 - 2.9e-14 53.0 7.0 2.4e-09 37.3 0.3 2.4 2 0 0 2 2 2 2 AP2 domain zf-NOSIP PF15906.5 AFZ81128.1 - 2.6e-09 37.1 0.0 1.2e-08 34.9 0.0 2.0 2 0 0 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein zf-C3HC4_4 PF15227.6 AFZ81128.1 - 0.00049 20.2 0.7 0.00049 20.2 0.7 1.9 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 AFZ81128.1 - 0.0049 16.7 0.4 0.01 15.7 0.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AFZ81128.1 - 0.0067 16.4 1.2 0.022 14.8 0.4 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 AFZ81128.1 - 0.059 13.2 0.5 0.15 12.0 0.5 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.12 AFZ81128.1 - 0.086 12.2 6.0 0.41 10.0 0.1 2.9 1 1 1 2 2 2 0 Rtf2 RING-finger zf-B_box PF00643.24 AFZ81129.1 - 1.2e-15 57.4 17.6 3.6e-08 33.4 8.6 2.5 2 0 0 2 2 2 2 B-box zinc finger PARP PF00644.20 AFZ81129.1 - 2.8e-06 27.0 0.2 9e-06 25.4 0.2 1.8 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain NIF PF03031.18 AFZ81131.1 - 2.7e-42 144.2 0.4 4.7e-42 143.4 0.4 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BolA PF01722.18 AFZ81131.1 - 3.8e-15 55.9 0.0 1.2e-14 54.4 0.0 1.9 1 0 0 1 1 1 1 BolA-like protein DUF2456 PF10445.9 AFZ81131.1 - 0.15 12.2 0.1 0.27 11.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2456) Ribosomal_S11 PF00411.19 AFZ81133.1 - 9.7e-47 157.9 0.6 1.3e-46 157.5 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein S11 Pilus_CpaD PF09476.10 AFZ81133.1 - 0.058 13.1 0.1 0.078 12.7 0.1 1.2 1 0 0 1 1 1 0 Pilus biogenesis CpaD protein (pilus_cpaD) DUF2252 PF10009.9 AFZ81133.1 - 0.064 12.3 0.0 0.077 12.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) PseudoU_synth_1 PF01416.20 AFZ81134.1 - 3.4e-22 78.9 0.0 5.6e-16 58.9 0.0 2.5 2 1 0 2 2 2 2 tRNA pseudouridine synthase DNA_ligase_OB_2 PF14743.6 AFZ81135.1 - 0.16 12.0 0.0 0.32 11.1 0.0 1.5 1 0 0 1 1 1 0 DNA ligase OB-like domain GTP_EFTU PF00009.27 AFZ81136.1 - 7e-18 64.9 0.7 2.9e-14 53.1 0.0 2.4 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 AFZ81136.1 - 1.1e-10 41.6 0.0 2.6e-10 40.4 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase IF-2 PF11987.8 AFZ81136.1 - 1.8e-10 40.9 3.2 4.4e-10 39.6 3.2 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 RsgA_GTPase PF03193.16 AFZ81136.1 - 1.8e-05 24.7 0.6 0.18 11.7 0.1 3.0 1 1 1 2 2 2 2 RsgA GTPase SRPRB PF09439.10 AFZ81136.1 - 0.00016 21.2 0.0 0.00035 20.0 0.0 1.6 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 AFZ81136.1 - 0.00033 20.4 0.4 0.00089 19.0 0.1 1.9 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Ras PF00071.22 AFZ81136.1 - 0.00068 19.3 0.0 0.0016 18.1 0.0 1.6 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AFZ81136.1 - 0.00087 19.5 0.0 0.0024 18.1 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 AFZ81136.1 - 0.0025 17.3 0.1 0.0073 15.9 0.1 1.9 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 AFZ81136.1 - 0.0057 16.7 0.0 1.3 9.0 0.0 2.6 1 1 1 2 2 2 1 Dynamin family IF2_N PF04760.15 AFZ81136.1 - 0.12 12.2 0.0 0.37 10.6 0.0 1.9 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region AAA_23 PF13476.6 AFZ81136.1 - 0.16 12.4 1.6 0.25 11.8 0.1 2.0 2 1 0 2 2 2 0 AAA domain HEPN_Apea PF18739.1 AFZ81137.1 - 0.097 13.1 2.3 0.72 10.3 1.1 2.5 1 1 1 2 2 2 0 Apea-like HEPN Ribosomal_L11_N PF03946.14 AFZ81138.1 - 2.8e-22 78.3 0.2 4e-22 77.8 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 AFZ81138.1 - 1.4e-13 51.2 0.0 2.3e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain DUF4184 PF13803.6 AFZ81139.1 - 0.002 17.9 0.6 0.004 16.9 0.2 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4184) Wzy_C PF04932.15 AFZ81139.1 - 0.017 14.8 1.3 0.14 11.8 0.7 2.1 2 0 0 2 2 2 0 O-Antigen ligase DUF2206 PF09971.9 AFZ81139.1 - 0.035 12.9 4.0 0.073 11.8 4.0 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) DUF2070 PF09843.9 AFZ81139.1 - 1 7.6 3.9 1.5 7.1 3.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) HTH_9 PF08221.11 AFZ81140.1 - 1.3e-12 47.6 6.9 1.1e-11 44.6 0.3 4.2 4 1 1 5 5 5 1 RNA polymerase III subunit RPC82 helix-turn-helix domain Rrf2 PF02082.20 AFZ81140.1 - 0.014 15.8 0.5 8.4 6.8 0.0 3.3 3 0 0 3 3 3 0 Transcriptional regulator MotA_activ PF09114.10 AFZ81140.1 - 0.5 10.5 3.8 0.77 9.9 0.0 3.1 4 0 0 4 4 4 0 Transcription factor MotA, activation domain WD40 PF00400.32 AFZ81141.1 - 3.4e-59 195.4 34.4 1.4e-10 41.5 0.1 9.1 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AFZ81141.1 - 2.8e-23 82.0 1.6 0.0002 21.6 0.0 6.4 2 2 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 AFZ81141.1 - 5.6e-10 39.6 0.7 1e-09 38.8 0.7 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.8 AFZ81141.1 - 1.8e-07 30.2 3.3 0.023 13.4 0.2 3.9 4 1 1 5 5 5 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 AFZ81141.1 - 1.5e-05 24.1 0.4 0.32 9.9 0.0 4.1 3 2 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 AFZ81141.1 - 2.9e-05 22.8 0.0 0.012 14.1 0.0 3.4 2 2 1 3 3 3 1 Cytochrome D1 heme domain WD40_like PF17005.5 AFZ81141.1 - 0.00029 20.3 0.0 1 8.6 0.0 4.0 4 0 0 4 4 4 1 WD40-like domain KcnmB2_inactiv PF09303.10 AFZ81141.1 - 0.033 14.0 1.2 0.11 12.3 1.2 1.9 1 0 0 1 1 1 0 KCNMB2, ball and chain domain PD40 PF07676.12 AFZ81141.1 - 0.045 13.7 7.2 33 4.6 0.1 4.8 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat FAST_1 PF06743.15 AFZ81142.1 - 0.081 12.9 1.7 1.4 8.9 0.0 3.2 2 1 1 3 3 3 0 FAST kinase-like protein, subdomain 1 RPAP1_C PF08620.10 AFZ81143.1 - 2.3e-19 69.3 0.0 4.8e-19 68.2 0.0 1.6 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 AFZ81143.1 - 0.0035 17.1 2.8 0.0035 17.1 2.8 2.0 2 0 0 2 2 2 1 RPAP1-like, N-terminal Arm PF00514.23 AFZ81143.1 - 9.7 6.4 5.8 18 5.6 0.0 3.5 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat WD40 PF00400.32 AFZ81144.1 - 3.8e-50 166.8 28.4 5.7e-11 42.8 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AFZ81144.1 - 7.3e-13 48.6 4.4 0.068 13.5 0.0 5.3 2 2 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 AFZ81144.1 - 2.2e-07 30.5 0.0 0.00012 21.5 0.0 2.7 3 1 0 3 3 3 2 WD40-like domain Ge1_WD40 PF16529.5 AFZ81144.1 - 3.3e-06 26.3 0.2 2.5 7.0 0.0 4.4 2 2 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 AFZ81144.1 - 0.00032 19.3 0.4 0.41 9.1 0.1 3.4 2 2 3 5 5 5 3 Cytochrome D1 heme domain PQQ_3 PF13570.6 AFZ81144.1 - 0.0051 17.3 1.3 0.11 13.1 0.1 3.3 3 0 0 3 3 3 1 PQQ-like domain SGL PF08450.12 AFZ81144.1 - 0.021 14.4 0.2 1.5 8.3 0.0 2.8 3 0 0 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region Nucleoporin_N PF08801.11 AFZ81144.1 - 0.062 12.0 3.0 4 6.1 0.1 3.1 1 1 0 2 2 2 0 Nup133 N terminal like PALB2_WD40 PF16756.5 AFZ81144.1 - 0.068 12.1 4.1 0.12 11.3 0.3 2.8 2 1 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Frtz PF11768.8 AFZ81144.1 - 0.11 10.8 0.0 1.1 7.5 0.0 2.0 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz PD40 PF07676.12 AFZ81144.1 - 0.15 12.1 1.4 46 4.1 0.1 3.8 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat LRR_4 PF12799.7 AFZ81145.1 - 3.9e-39 132.0 41.6 3.3e-10 40.0 1.1 7.7 4 1 4 8 8 8 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 AFZ81145.1 - 6.8e-22 77.0 33.2 1.3e-09 37.7 0.6 6.1 2 1 5 7 7 7 6 Leucine rich repeat LRR_9 PF14580.6 AFZ81145.1 - 2.3e-21 76.1 18.7 2.9e-09 36.7 5.9 3.8 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 AFZ81145.1 - 1e-07 31.5 29.7 4.1 8.3 0.2 9.5 7 4 0 7 7 7 5 Leucine Rich Repeat LRR_6 PF13516.6 AFZ81145.1 - 6.3e-06 25.8 27.4 0.5 10.6 0.6 9.2 10 0 0 10 10 10 3 Leucine Rich repeat LRR_2 PF07723.13 AFZ81145.1 - 3.7 8.4 7.7 70 4.3 0.2 4.8 3 2 2 5 5 5 0 Leucine Rich Repeat SpoU_methylase PF00588.19 AFZ81146.1 - 3.6e-06 27.2 0.0 8e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 SpoU rRNA Methylase family PCI PF01399.27 AFZ81148.1 - 3.6e-10 40.3 2.5 8.8e-10 39.0 0.3 2.5 2 1 0 2 2 2 1 PCI domain Colipase-like PF15083.6 AFZ81148.1 - 0.0016 18.5 2.9 0.0019 18.3 0.2 2.3 3 0 0 3 3 3 1 Colipase-like Peptidase_M22 PF00814.25 AFZ81149.1 - 9.7e-75 251.7 0.0 1.1e-74 251.5 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family DUF3752 PF12572.8 AFZ81150.1 - 1.5e-06 28.8 1.1 1.5e-06 28.8 1.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3752) Dynamin_M PF01031.20 AFZ81151.1 - 3.2e-75 253.0 2.0 9.8e-75 251.4 0.1 2.4 1 1 2 3 3 3 1 Dynamin central region Dynamin_N PF00350.23 AFZ81151.1 - 6.6e-47 159.7 0.0 2.1e-46 158.1 0.0 1.9 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 AFZ81151.1 - 3.8e-24 84.7 1.2 1.4e-23 82.9 0.1 2.4 2 1 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 AFZ81151.1 - 0.00035 20.6 0.0 0.0012 18.9 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase CH_2 PF06294.11 AFZ81151.1 - 0.097 12.8 0.2 0.45 10.7 0.1 2.2 2 0 0 2 2 2 0 CH-like domain in sperm protein Adaptin_N PF01602.20 AFZ81152.1 - 1.9e-63 214.8 16.1 3.1e-63 214.1 16.1 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_g_Cpla PF16381.5 AFZ81152.1 - 9.3e-24 83.8 0.0 2.6e-23 82.3 0.0 1.9 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform COP-gamma_platf PF08752.10 AFZ81152.1 - 6.3e-13 49.1 4.5 1.4e-12 48.0 3.6 2.1 2 0 0 2 2 2 1 Coatomer gamma subunit appendage platform subdomain Cnd1 PF12717.7 AFZ81152.1 - 5.6e-08 33.0 3.6 5.6e-08 33.0 3.6 4.7 2 1 2 5 5 5 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 AFZ81152.1 - 2.1e-06 28.0 0.0 0.18 12.2 0.0 4.6 4 0 0 4 4 4 2 HEAT repeats Coatomer_b_Cpla PF14806.6 AFZ81152.1 - 0.00036 20.5 1.9 0.0073 16.3 0.0 3.1 3 0 0 3 3 3 1 Coatomer beta subunit appendage platform DSS1_SEM1 PF05160.13 AFZ81153.1 - 0.024 14.7 18.8 0.072 13.2 18.7 1.9 1 1 0 1 1 1 0 DSS1/SEM1 family NOD2_WH PF17779.1 AFZ81153.1 - 0.11 12.9 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 NOD2 winged helix domain Ccdc124 PF06244.12 AFZ81155.1 - 7.4e-31 107.4 3.2 7.4e-31 107.4 3.2 2.7 2 1 0 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 HMG_box PF00505.19 AFZ81155.1 - 0.031 14.7 0.5 0.031 14.7 0.5 2.6 2 0 0 2 2 2 0 HMG (high mobility group) box Polysacc_synt_2 PF02719.15 AFZ81155.1 - 0.056 12.6 2.2 0.073 12.2 2.2 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF2894 PF11445.8 AFZ81155.1 - 0.23 11.9 12.3 0.38 11.2 12.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2894) DHHC PF01529.20 AFZ81156.1 - 9.5e-33 113.2 16.4 9.5e-33 113.2 16.4 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase zf-CDGSH PF09360.10 AFZ81157.1 - 2.1e-08 34.3 0.5 4.3e-08 33.3 0.5 1.6 1 0 0 1 1 1 1 Iron-binding zinc finger CDGSH type CDC73_C PF05179.14 AFZ81158.1 - 2.4e-40 137.8 0.4 5.6e-40 136.6 0.4 1.6 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal CRAL_TRIO_N PF03765.15 AFZ81158.1 - 0.027 14.7 1.0 0.055 13.7 0.1 2.0 2 0 0 2 2 2 0 CRAL/TRIO, N-terminal domain NUDIX PF00293.28 AFZ81159.1 - 2.8e-18 66.2 0.0 3.3e-18 66.0 0.0 1.0 1 0 0 1 1 1 1 NUDIX domain LSM PF01423.22 AFZ81160.1 - 1.4e-12 47.1 0.1 2.4e-12 46.4 0.1 1.3 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 AFZ81160.1 - 0.02 14.5 0.1 0.039 13.6 0.1 1.4 1 0 0 1 1 1 0 Hfq protein LSM14 PF12701.7 AFZ81160.1 - 0.028 14.5 0.0 0.047 13.8 0.0 1.4 1 0 0 1 1 1 0 Scd6-like Sm domain VWA PF00092.28 AFZ81161.1 - 1.4e-26 93.8 0.1 2.9e-26 92.8 0.1 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 AFZ81161.1 - 9.5e-12 45.5 0.2 2.4e-11 44.2 0.2 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 AFZ81161.1 - 0.041 13.3 0.6 0.16 11.3 0.6 1.9 1 1 0 1 1 1 0 VWA domain containing CoxE-like protein TSP_1 PF00090.19 AFZ81161.1 - 0.46 10.7 0.1 0.46 10.7 0.1 2.3 2 0 0 2 2 2 0 Thrombospondin type 1 domain DAPDH_C PF16654.5 AFZ81162.1 - 0.013 15.3 0.3 0.11 12.3 0.1 2.1 2 0 0 2 2 2 0 Diaminopimelic acid dehydrogenase C-terminal domain VWA PF00092.28 AFZ81163.1 - 2.6e-28 99.5 0.0 4.1e-28 98.8 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 AFZ81163.1 - 5.7e-11 43.0 0.0 1.5e-10 41.7 0.0 1.7 2 0 0 2 2 2 1 von Willebrand factor type A domain TSP_1 PF00090.19 AFZ81163.1 - 0.00037 20.7 9.2 0.002 18.3 9.2 2.3 1 1 0 1 1 1 1 Thrombospondin type 1 domain PTN_MK_C PF01091.18 AFZ81163.1 - 1.8 9.0 5.0 0.36 11.3 0.6 2.1 2 0 0 2 2 2 0 PTN/MK heparin-binding protein family, C-terminal domain S4 PF01479.25 AFZ81166.1 - 3.5e-12 45.8 0.6 8.4e-12 44.6 0.1 1.9 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 AFZ81166.1 - 9.1e-07 29.7 1.5 1.1e-05 26.2 0.5 2.3 1 1 1 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain RE_LlaMI PF09562.10 AFZ81166.1 - 0.058 13.0 0.1 0.071 12.7 0.1 1.1 1 0 0 1 1 1 0 LlaMI restriction endonuclease DUF5624 PF18538.1 AFZ81167.1 - 0.067 13.3 0.1 0.17 12.0 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5624) SPT16 PF08644.11 AFZ81168.1 - 7.8e-48 162.5 0.7 7.8e-48 162.5 0.7 2.7 3 0 0 3 3 3 1 FACT complex subunit (SPT16/CDC68) Peptidase_M24 PF00557.24 AFZ81168.1 - 2.7e-22 79.5 0.1 4.8e-22 78.7 0.1 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 FACT-Spt16_Nlob PF14826.6 AFZ81168.1 - 2.2e-19 69.8 4.3 3.7e-19 69.1 0.0 2.8 3 0 0 3 3 3 1 FACT complex subunit SPT16 N-terminal lobe domain Rtt106 PF08512.12 AFZ81168.1 - 1.1e-14 54.6 0.1 5.3e-14 52.4 0.0 2.3 3 0 0 3 3 3 1 Histone chaperone Rttp106-like RRM_1 PF00076.22 AFZ81169.1 - 5.9e-31 106.1 0.0 1.1e-19 70.0 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AFZ81169.1 - 0.0048 16.7 0.0 0.0085 15.9 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_7 PF16367.5 AFZ81169.1 - 0.012 15.7 0.0 0.032 14.3 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif RSRP PF17069.5 AFZ81169.1 - 0.56 9.7 26.2 0.89 9.1 26.2 1.3 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 PRP38_assoc PF12871.7 AFZ81169.1 - 3.1 8.5 29.0 1.2 9.8 24.3 2.2 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Transposase_24 PF03004.14 AFZ81170.1 - 0.025 14.7 4.3 0.038 14.1 1.0 2.3 2 0 0 2 2 2 0 Plant transposase (Ptta/En/Spm family) Proteasome PF00227.26 AFZ81171.1 - 4.3e-35 120.9 0.4 5e-35 120.7 0.4 1.1 1 0 0 1 1 1 1 Proteasome subunit DUF4432 PF14486.6 AFZ81172.1 - 0.0058 15.5 0.2 0.045 12.5 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4432) TIG PF01833.24 AFZ81172.1 - 0.032 14.3 0.4 0.12 12.5 0.4 2.0 1 0 0 1 1 1 0 IPT/TIG domain Cyclin PF08613.11 AFZ81173.1 - 1.2e-31 110.2 2.1 2e-31 109.5 2.1 1.3 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 AFZ81173.1 - 7.5e-12 45.1 0.2 1.2e-11 44.5 0.2 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain ATP-synt_C PF00137.21 AFZ81174.1 - 1.3e-30 105.5 30.8 1.7e-17 63.5 11.7 2.1 2 0 0 2 2 2 2 ATP synthase subunit C DUF2970 PF11174.8 AFZ81174.1 - 0.13 12.2 0.5 0.13 12.2 0.5 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF2970) Ribosomal_L14 PF00238.19 AFZ81175.1 - 1.3e-16 60.8 0.7 2.3e-16 60.0 0.7 1.3 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e SLBP_RNA_bind PF15247.6 AFZ81175.1 - 1.1e-15 57.5 3.5 1.7e-15 56.8 3.5 1.4 1 0 0 1 1 1 1 Histone RNA hairpin-binding protein RNA-binding domain YqaH PF17448.2 AFZ81175.1 - 0.054 13.8 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized YqaH-like EssA PF10661.9 AFZ81176.1 - 1 9.2 5.3 0.61 9.9 0.3 2.2 1 1 0 2 2 2 0 WXG100 protein secretion system (Wss), protein EssA tRNA-synt_1d PF00750.19 AFZ81177.1 - 4.3e-115 384.4 1.0 4.3e-115 384.4 1.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class I (R) DALR_1 PF05746.15 AFZ81177.1 - 1.1e-29 103.1 0.0 2.8e-29 101.7 0.0 1.8 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 AFZ81177.1 - 1.5e-15 57.6 0.0 3.3e-15 56.4 0.0 1.6 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1e PF01406.19 AFZ81177.1 - 4.4e-05 23.0 0.1 9.6e-05 21.9 0.1 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 AFZ81177.1 - 0.0046 15.7 0.1 0.11 11.2 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class I (M) DUF1884 PF08967.10 AFZ81177.1 - 0.022 15.0 0.8 0.25 11.6 0.0 2.9 3 1 1 4 4 4 0 Domain of unknown function (DUF1884) E2_bind PF08825.10 AFZ81177.1 - 0.14 12.4 0.1 14 5.9 0.0 2.7 2 0 0 2 2 2 0 E2 binding domain Hydrolase_4 PF12146.8 AFZ81178.1 - 1.5e-20 73.5 0.0 2.1e-19 69.8 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 AFZ81178.1 - 1.1e-06 29.4 0.0 1.7e-06 28.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 AFZ81178.1 - 4.3e-06 26.6 0.4 3.4e-05 23.6 0.2 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 AFZ81178.1 - 0.011 15.6 0.0 0.026 14.4 0.0 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 AFZ81178.1 - 0.013 15.6 0.1 0.034 14.2 0.0 1.7 2 0 0 2 2 2 0 TAP-like protein DUF2974 PF11187.8 AFZ81178.1 - 0.013 15.0 0.0 0.022 14.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) NAD_binding_8 PF13450.6 AFZ81178.1 - 0.013 15.7 0.1 0.036 14.3 0.0 1.7 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain DLH PF01738.18 AFZ81178.1 - 0.041 13.4 0.6 0.84 9.1 0.0 2.6 2 1 1 3 3 3 0 Dienelactone hydrolase family FSH1 PF03959.13 AFZ81178.1 - 0.041 13.5 0.1 1.9 8.1 0.0 2.1 2 0 0 2 2 2 0 Serine hydrolase (FSH1) LIDHydrolase PF10230.9 AFZ81178.1 - 0.051 13.1 0.0 0.084 12.4 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase DUF676 PF05057.14 AFZ81178.1 - 0.068 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Peptidase_S9 PF00326.21 AFZ81178.1 - 0.092 12.2 0.0 7.3 6.0 0.0 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family Lipase_3 PF01764.25 AFZ81178.1 - 0.16 11.8 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Fungus-induced PF10917.8 AFZ81179.1 - 0.46 10.8 0.1 0.46 10.8 0.1 3.1 4 0 0 4 4 4 0 Fungus-induced protein PI3_PI4_kinase PF00454.27 AFZ81182.1 - 8.3e-32 111.0 0.7 4.3e-30 105.3 0.7 2.5 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 AFZ81182.1 - 0.032 13.6 0.2 0.11 11.9 0.0 2.0 2 0 0 2 2 2 0 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 AFZ81182.1 - 0.083 12.2 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) Ribosomal_L13 PF00572.18 AFZ81183.1 - 3e-09 37.2 0.0 1.4e-07 31.8 0.0 2.3 1 1 0 1 1 1 1 Ribosomal protein L13 Syntaxin_2 PF14523.6 AFZ81184.1 - 0.00044 20.6 9.7 0.13 12.6 2.4 3.1 3 1 1 4 4 4 2 Syntaxin-like protein Syntaxin PF00804.25 AFZ81184.1 - 0.0024 17.6 7.2 0.25 11.0 0.2 2.3 1 1 0 2 2 2 2 Syntaxin FapA PF03961.13 AFZ81184.1 - 0.0079 14.9 1.5 0.016 13.9 0.3 1.8 2 0 0 2 2 2 1 Flagellar Assembly Protein A Synaptobrevin PF00957.21 AFZ81184.1 - 0.011 15.5 1.0 0.011 15.5 1.0 2.7 2 1 1 3 3 3 0 Synaptobrevin DUF3781 PF12636.7 AFZ81184.1 - 0.012 15.4 0.9 0.13 12.2 0.9 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3781) SKA1 PF07160.12 AFZ81184.1 - 0.022 14.6 4.2 0.19 11.6 0.2 2.3 2 1 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Aldedh PF00171.22 AFZ81184.1 - 0.093 11.2 0.0 0.13 10.8 0.0 1.2 1 0 0 1 1 1 0 Aldehyde dehydrogenase family DUF5499 PF17603.2 AFZ81184.1 - 0.19 12.4 3.4 6.1 7.5 0.3 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5499) zf-C2H2_jaz PF12171.8 AFZ81185.1 - 1.2e-07 31.8 0.6 2e-07 31.1 0.6 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 AFZ81185.1 - 1.3e-07 31.8 1.1 2.4e-07 30.9 0.7 1.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-U1 PF06220.12 AFZ81185.1 - 0.0015 18.3 0.5 0.0029 17.3 0.5 1.4 1 0 0 1 1 1 1 U1 zinc finger zf_C2H2_ZHX PF18387.1 AFZ81185.1 - 0.011 15.4 0.0 0.022 14.4 0.0 1.5 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF4829 PF16111.5 AFZ81185.1 - 0.017 15.9 1.1 0.034 14.9 1.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4829) zf-DBF PF07535.12 AFZ81185.1 - 0.059 13.5 0.1 0.11 12.7 0.1 1.4 1 0 0 1 1 1 0 DBF zinc finger Metal_resist PF13801.6 AFZ81185.1 - 0.2 11.9 6.2 8.4 6.6 4.5 2.4 1 1 1 2 2 2 0 Heavy-metal resistance WDCP PF15390.6 AFZ81185.1 - 0.22 9.8 2.7 0.26 9.6 2.7 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Cytochrom_C1 PF02167.15 AFZ81186.1 - 1.1e-92 309.7 0.0 1.6e-92 309.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 AFZ81186.1 - 0.0039 17.5 0.2 0.0083 16.4 0.2 1.7 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 AFZ81186.1 - 0.007 17.5 0.0 0.02 16.0 0.0 1.9 1 0 0 1 1 1 1 Cytochrome c Gp_dh_C PF02800.20 AFZ81187.1 - 1.4e-68 229.5 0.0 1.9e-68 229.0 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 AFZ81187.1 - 8.5e-35 119.1 0.0 1.2e-33 115.5 0.0 2.3 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain ADH_zinc_N PF00107.26 AFZ81187.1 - 0.01 15.8 0.1 0.033 14.2 0.1 1.8 1 1 1 2 2 2 0 Zinc-binding dehydrogenase DapB_N PF01113.20 AFZ81187.1 - 0.011 15.9 0.6 0.077 13.1 0.1 2.4 2 1 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus AAA PF00004.29 AFZ81189.1 - 8.7e-12 45.6 0.0 1.8e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 AFZ81189.1 - 2.9e-08 34.5 3.1 3.1e-08 34.4 0.3 2.2 1 1 0 2 2 2 1 AAA domain NACHT PF05729.12 AFZ81189.1 - 5.4e-06 26.4 0.0 9.7e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_29 PF13555.6 AFZ81189.1 - 1e-05 25.1 0.0 2.7e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 AFZ81189.1 - 1.1e-05 25.9 0.1 6.8e-05 23.4 0.0 2.3 3 0 0 3 3 3 1 ABC transporter AAA_15 PF13175.6 AFZ81189.1 - 2.5e-05 24.2 0.3 2.5e-05 24.2 0.3 1.8 2 0 0 2 2 2 1 AAA ATPase domain ABC_ATPase PF09818.9 AFZ81189.1 - 0.00059 18.7 0.0 0.00097 18.0 0.0 1.3 1 0 0 1 1 1 1 Predicted ATPase of the ABC class VirE PF05272.11 AFZ81189.1 - 0.00086 19.1 0.0 0.0017 18.2 0.0 1.4 1 0 0 1 1 1 1 Virulence-associated protein E AAA_22 PF13401.6 AFZ81189.1 - 0.0012 19.1 0.7 0.011 16.0 0.4 2.7 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.6 AFZ81189.1 - 0.0053 17.2 0.0 0.016 15.6 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.15 AFZ81189.1 - 0.012 15.5 0.0 0.023 14.6 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain RNA_helicase PF00910.22 AFZ81189.1 - 0.018 15.4 0.1 0.056 13.8 0.1 1.9 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.6 AFZ81189.1 - 0.02 14.6 0.0 0.039 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 AFZ81189.1 - 0.025 14.0 0.1 0.081 12.4 0.0 1.8 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_27 PF13514.6 AFZ81189.1 - 0.028 14.0 0.0 0.05 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 AFZ81189.1 - 0.034 14.0 0.2 0.12 12.3 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase MMR_HSR1 PF01926.23 AFZ81189.1 - 0.052 13.6 0.0 0.18 11.9 0.0 2.1 2 0 0 2 2 2 0 50S ribosome-binding GTPase Roc PF08477.13 AFZ81189.1 - 0.052 13.8 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 AFZ81189.1 - 0.06 13.9 0.2 0.17 12.5 0.2 1.8 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 AFZ81189.1 - 0.061 12.7 0.0 0.094 12.0 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF815 PF05673.13 AFZ81189.1 - 0.067 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_25 PF13481.6 AFZ81189.1 - 0.13 11.9 0.0 0.55 9.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 AFZ81189.1 - 0.18 11.9 0.0 0.35 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 AFZ81190.1 - 1.4e-15 57.8 0.0 3.1e-15 56.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 AFZ81190.1 - 1.6e-15 57.3 1.5 2.9e-14 53.2 0.3 2.9 2 1 0 2 2 2 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 AFZ81190.1 - 3.6e-14 52.9 0.2 1.2e-13 51.2 0.2 2.0 1 0 0 1 1 1 1 Replication factor C C-terminal domain Rad17 PF03215.15 AFZ81190.1 - 1.3e-09 38.2 0.0 2.5e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_30 PF13604.6 AFZ81190.1 - 2.8e-08 33.7 0.0 4.5e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 AFZ81190.1 - 3.5e-07 30.6 0.0 1.2e-06 28.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 AFZ81190.1 - 4.5e-06 27.2 0.0 3.2e-05 24.4 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 AFZ81190.1 - 7.5e-06 25.8 0.1 9.1e-05 22.2 0.0 2.6 3 1 2 5 5 5 1 Holliday junction DNA helicase RuvB P-loop domain AAA_19 PF13245.6 AFZ81190.1 - 1.2e-05 25.6 0.1 3.6e-05 24.1 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 AFZ81190.1 - 4.8e-05 23.3 1.1 0.0002 21.2 0.1 2.1 2 1 1 3 3 2 1 AAA domain AAA_assoc_2 PF16193.5 AFZ81190.1 - 9.3e-05 22.7 0.0 0.00025 21.3 0.0 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA_24 PF13479.6 AFZ81190.1 - 0.0001 22.1 0.0 0.00019 21.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 AFZ81190.1 - 0.00013 21.9 0.1 0.0003 20.8 0.1 1.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) ResIII PF04851.15 AFZ81190.1 - 0.0002 21.4 0.2 0.056 13.4 0.0 2.3 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_14 PF13173.6 AFZ81190.1 - 0.00033 20.7 0.0 0.00069 19.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 AFZ81190.1 - 0.00051 20.6 0.1 0.0011 19.5 0.1 1.5 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 AFZ81190.1 - 0.00085 19.8 0.1 0.0028 18.2 0.0 1.8 2 0 0 2 2 2 1 ABC transporter DUF2075 PF09848.9 AFZ81190.1 - 0.0011 18.2 1.1 0.0032 16.8 1.1 1.6 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) TniB PF05621.11 AFZ81190.1 - 0.0029 17.0 0.2 0.059 12.8 0.2 2.4 1 1 0 1 1 1 1 Bacterial TniB protein Mg_chelatase PF01078.21 AFZ81190.1 - 0.0075 15.7 0.1 0.039 13.3 0.1 2.0 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI TK PF00265.18 AFZ81190.1 - 0.01 15.7 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 0 Thymidine kinase DEAD PF00270.29 AFZ81190.1 - 0.017 14.9 0.5 0.19 11.5 0.1 2.4 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_7 PF12775.7 AFZ81190.1 - 0.038 13.5 0.0 0.072 12.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_29 PF13555.6 AFZ81190.1 - 0.066 13.0 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_3 PF07726.11 AFZ81190.1 - 0.075 12.9 0.1 0.2 11.5 0.1 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 AFZ81190.1 - 0.077 13.2 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 AFZ81190.1 - 0.077 13.4 0.2 0.32 11.4 0.2 2.1 1 1 0 1 1 1 0 RNA helicase PTPlike_phytase PF14566.6 AFZ81190.1 - 0.086 13.0 0.1 0.92 9.6 0.0 2.4 3 0 0 3 3 2 0 Inositol hexakisphosphate AAA_28 PF13521.6 AFZ81190.1 - 0.11 12.8 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 AFZ81190.1 - 0.11 13.0 0.0 0.25 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 AFZ81190.1 - 0.12 11.7 0.0 0.29 10.4 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF2247 PF10004.9 AFZ81190.1 - 0.15 11.8 0.6 0.8 9.5 0.1 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2247) CBFD_NFYB_HMF PF00808.23 AFZ81191.1 - 0.00017 21.8 0.9 0.00027 21.2 0.3 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 AFZ81191.1 - 0.00098 19.5 0.2 0.0015 18.9 0.2 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Urocanase PF01175.18 AFZ81191.1 - 0.055 13.1 0.0 0.069 12.8 0.0 1.2 1 0 0 1 1 1 0 Urocanase Rossmann-like domain ANAPC4_WD40 PF12894.7 AFZ81192.1 - 0.00044 20.5 0.2 2 8.8 0.0 5.2 5 1 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AFZ81192.1 - 0.00045 21.0 0.3 20 6.3 0.0 6.4 6 0 0 6 6 6 1 WD domain, G-beta repeat DED PF01335.21 AFZ81193.1 - 0.029 14.7 0.9 0.078 13.3 0.9 1.8 1 0 0 1 1 1 0 Death effector domain RabGAP-TBC PF00566.18 AFZ81194.1 - 4.6e-50 170.3 2.5 5.8e-50 169.9 2.5 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Thioredoxin_8 PF13905.6 AFZ81195.1 - 5e-50 167.8 0.3 5.8e-24 84.2 0.0 2.9 3 0 0 3 3 3 2 Thioredoxin-like Thioredoxin_2 PF13098.6 AFZ81195.1 - 0.00098 19.6 0.0 1 9.9 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_6 PF13848.6 AFZ81195.1 - 0.0012 18.8 6.7 0.0019 18.1 0.3 3.4 4 1 0 4 4 4 1 Thioredoxin-like domain AhpC-TSA PF00578.21 AFZ81195.1 - 0.0013 18.6 0.1 0.058 13.3 0.0 3.2 4 0 0 4 4 4 1 AhpC/TSA family COX6C PF02937.15 AFZ81195.1 - 0.076 13.1 0.2 0.25 11.5 0.2 1.9 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIc Sec62 PF03839.16 AFZ81197.1 - 0.37 10.3 11.3 0.38 10.2 11.3 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Membralin PF09746.9 AFZ81197.1 - 0.44 9.5 2.0 0.54 9.2 2.0 1.0 1 0 0 1 1 1 0 Tumour-associated protein Zip PF02535.22 AFZ81197.1 - 0.73 9.0 2.3 0.77 8.9 2.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Ndc1_Nup PF09531.10 AFZ81197.1 - 0.95 8.1 2.4 0.85 8.2 2.4 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF3807 PF12720.7 AFZ81197.1 - 5.1 7.3 15.1 6.4 7.0 15.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) NPR3 PF03666.13 AFZ81197.1 - 7.5 5.2 10.4 7.6 5.2 10.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Cnd1 PF12717.7 AFZ81198.1 - 9.6e-30 103.8 1.9 9.6e-30 103.8 1.9 4.2 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Nipped-B_C PF12830.7 AFZ81198.1 - 0.00031 20.7 0.8 0.0021 18.0 0.3 2.7 2 0 0 2 2 2 1 Sister chromatid cohesion C-terminus ENTH PF01417.20 AFZ81198.1 - 0.16 12.0 3.0 1.3 9.1 3.0 2.7 1 0 0 1 1 1 0 ENTH domain CTK3 PF12243.8 AFZ81198.1 - 0.19 11.7 2.8 1.4 9.0 0.6 3.2 3 0 0 3 3 3 0 CTD kinase subunit gamma CTK3 XRN_M PF17846.1 AFZ81199.1 - 4.8e-110 368.5 2.0 4.8e-110 368.5 2.0 1.5 2 0 0 2 2 2 1 Xrn1 helical domain XRN_N PF03159.18 AFZ81199.1 - 5.5e-99 330.5 0.0 5.5e-99 330.5 0.0 1.7 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus VWA_2 PF13519.6 AFZ81200.1 - 3.1e-13 50.3 0.1 1.8e-12 47.9 0.0 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain CREPT PF16566.5 AFZ81200.1 - 0.042 14.0 0.3 0.34 11.1 0.1 2.3 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Ssl1 PF04056.14 AFZ81200.1 - 0.053 13.3 0.3 0.096 12.5 0.3 1.4 1 0 0 1 1 1 0 Ssl1-like Glutaredoxin PF00462.24 AFZ81200.1 - 0.081 13.2 0.5 0.41 10.9 0.0 2.3 3 0 0 3 3 3 0 Glutaredoxin V-ATPase_H_C PF11698.8 AFZ81200.1 - 0.085 13.0 0.4 0.25 11.5 0.1 2.0 2 0 0 2 2 2 0 V-ATPase subunit H Med21 PF11221.8 AFZ81200.1 - 0.13 12.5 1.9 3.2 8.0 0.0 3.1 3 0 0 3 3 3 0 Subunit 21 of Mediator complex tRNA-synt_1b PF00579.25 AFZ81201.1 - 1.1e-49 169.4 0.0 1.4e-49 169.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Proteasome PF00227.26 AFZ81202.1 - 4.1e-28 98.2 0.0 8.4e-28 97.2 0.0 1.6 1 1 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AFZ81202.1 - 2.9e-13 49.2 0.0 5.1e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Peptidase_S9 PF00326.21 AFZ81203.1 - 1.1e-25 90.4 0.0 1.8e-25 89.7 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family ENTH PF01417.20 AFZ81203.1 - 0.0072 16.4 0.4 0.017 15.2 0.4 1.6 1 0 0 1 1 1 1 ENTH domain RecG_N PF17190.4 AFZ81203.1 - 0.13 13.0 1.1 4.5 8.1 0.5 2.5 2 0 0 2 2 2 0 RecG N-terminal helical domain DUF956 PF06115.11 AFZ81203.1 - 0.14 11.9 0.1 0.38 10.5 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF956) DSHCT PF08148.12 AFZ81204.1 - 1.5e-47 161.3 0.0 3.7e-47 160.0 0.0 1.7 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 AFZ81204.1 - 4.5e-19 68.9 0.0 1e-18 67.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 AFZ81204.1 - 2.9e-07 30.7 0.0 9.1e-07 29.0 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 AFZ81204.1 - 4.6e-07 30.2 2.6 6.2e-06 26.5 0.2 3.7 2 1 0 2 2 2 1 Helicase conserved C-terminal domain rRNA_proc-arch PF13234.6 AFZ81204.1 - 7.3e-05 22.8 6.0 7.3e-05 22.8 6.0 2.6 2 1 0 2 2 2 1 rRNA-processing arch domain ATPase_2 PF01637.18 AFZ81204.1 - 0.035 14.0 0.1 0.15 12.0 0.1 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea La_HTH_kDCL PF18177.1 AFZ81204.1 - 0.051 13.9 1.0 7.1 7.0 0.3 2.7 2 0 0 2 2 2 0 La HTH in kinetoplastid DICER domain Chordopox_A30L PF06015.12 AFZ81204.1 - 0.08 12.8 1.0 1.2 9.0 0.3 3.0 2 0 0 2 2 2 0 Chordopoxvirus A30L protein IBN_N PF03810.19 AFZ81205.1 - 4.3e-05 23.3 1.4 0.00094 19.1 0.1 3.6 3 1 1 4 4 4 1 Importin-beta N-terminal domain RVT_1 PF00078.27 AFZ81205.1 - 0.0062 16.1 0.0 0.018 14.6 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) WD40 PF00400.32 AFZ81206.1 - 2.7e-08 34.3 11.7 8.3e-05 23.3 0.1 5.1 6 0 0 6 6 6 2 WD domain, G-beta repeat zf-tcix PF14952.6 AFZ81206.1 - 0.005 16.4 2.4 0.013 15.1 2.4 1.7 1 0 0 1 1 1 1 Putative treble-clef, zinc-finger, Zn-binding Mcl1_mid PF12341.8 AFZ81206.1 - 0.0068 15.8 0.0 0.018 14.4 0.0 1.6 1 1 0 1 1 1 1 Minichromosome loss protein, Mcl1, middle region ANAPC4_WD40 PF12894.7 AFZ81206.1 - 0.0097 16.2 0.0 4.7 7.6 0.0 4.5 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 AFZ81206.1 - 0.018 15.5 3.8 16 6.1 0.0 4.1 3 1 1 4 4 4 0 PQQ-like domain DUF974 PF06159.13 AFZ81207.1 - 7.6e-06 25.9 0.1 2.6e-05 24.2 0.1 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF974) A2M PF00207.22 AFZ81207.1 - 0.036 13.9 0.0 3.8 7.4 0.0 2.7 2 0 0 2 2 2 0 Alpha-2-macroglobulin family Transglut_C PF00927.22 AFZ81207.1 - 0.063 13.4 0.1 3.3 7.9 0.1 2.5 2 0 0 2 2 2 0 Transglutaminase family, C-terminal ig like domain DUF2393 PF09624.10 AFZ81207.1 - 0.076 13.0 1.1 2.1 8.4 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2393) MFAP1 PF06991.11 AFZ81208.1 - 4.8e-64 216.2 23.4 4.8e-64 216.2 23.4 2.2 1 1 1 2 2 2 1 Microfibril-associated/Pre-mRNA processing Y2_Tnp PF04986.13 AFZ81208.1 - 1 9.4 7.1 2.4 8.2 4.6 2.7 2 1 0 2 2 2 0 Putative transposase DUF2362 PF10154.9 AFZ81209.1 - 1.4e-11 44.0 0.2 3.7e-10 39.4 0.0 2.6 2 1 1 3 3 3 2 Uncharacterized conserved protein (DUF2362) LSM PF01423.22 AFZ81210.1 - 6.6e-15 54.6 0.3 8.1e-15 54.3 0.3 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 AFZ81210.1 - 0.12 12.5 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Ataxin 2 SM domain 2OG-FeII_Oxy_5 PF13759.6 AFZ81210.1 - 0.17 12.3 0.0 0.21 12.0 0.0 1.1 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase RINGv PF12906.7 AFZ81211.1 - 3.3e-12 46.3 8.4 8e-12 45.1 8.4 1.7 1 0 0 1 1 1 1 RING-variant domain FHA PF00498.26 AFZ81211.1 - 8.2e-12 45.3 0.5 3.4e-10 40.1 0.2 2.8 3 0 0 3 3 3 1 FHA domain Yop-YscD_cpl PF16697.5 AFZ81211.1 - 5.5e-11 42.6 0.0 1.1e-09 38.5 0.0 2.4 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain DUF587 PF04532.12 AFZ81211.1 - 0.058 12.7 0.6 0.096 12.0 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF587) zf-RING_2 PF13639.6 AFZ81211.1 - 0.095 13.1 5.4 0.31 11.4 5.4 1.9 1 0 0 1 1 1 0 Ring finger domain V-ATPase_H_C PF11698.8 AFZ81212.1 - 0.0018 18.4 0.3 0.01 15.9 0.0 2.4 2 0 0 2 2 2 1 V-ATPase subunit H FAST_1 PF06743.15 AFZ81212.1 - 0.019 14.9 5.6 0.22 11.5 0.2 3.9 3 0 0 3 3 3 0 FAST kinase-like protein, subdomain 1 SRP_TPR_like PF17004.5 AFZ81213.1 - 0.0023 17.9 0.7 0.5 10.4 0.0 2.8 2 0 0 2 2 2 2 Putative TPR-like repeat ANAPC3 PF12895.7 AFZ81213.1 - 0.69 10.2 5.4 5.6 7.3 0.3 3.8 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 tRNA_lig_CPD PF08302.11 AFZ81214.1 - 0.00061 19.3 1.4 0.043 13.3 0.1 2.3 2 0 0 2 2 2 2 Fungal tRNA ligase phosphodiesterase domain LigT_PEase PF02834.16 AFZ81214.1 - 0.0099 16.0 0.0 1.5 9.1 0.0 2.4 2 0 0 2 2 2 2 LigT like Phosphoesterase DUF1638 PF07796.11 AFZ81214.1 - 0.026 14.6 0.3 0.064 13.3 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1638) FtsJ PF01728.19 AFZ81215.1 - 1.6e-56 191.2 0.0 1.9e-56 191.0 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 AFZ81215.1 - 0.00054 19.8 0.1 0.024 14.5 0.1 2.6 1 1 0 1 1 1 1 Methyltransferase domain Gar1 PF04410.14 AFZ81216.1 - 3e-37 127.8 0.1 3.7e-37 127.5 0.1 1.1 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region HORMA PF02301.18 AFZ81218.1 - 1.1e-51 175.5 0.0 1.4e-51 175.2 0.0 1.0 1 0 0 1 1 1 1 HORMA domain PRP3 PF08572.10 AFZ81219.1 - 1.4e-62 211.4 17.6 1.4e-62 211.4 17.6 2.2 3 0 0 3 3 3 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 AFZ81219.1 - 1e-32 113.2 0.2 1e-32 113.2 0.2 2.9 3 1 0 3 3 3 1 Protein of unknown function (DUF1115) DUF5352 PF17303.2 AFZ81219.1 - 0.71 9.7 0.0 0.71 9.7 0.0 2.6 4 1 0 4 4 4 0 Family of unknown function (DUF5352) UCR_hinge PF02320.16 AFZ81220.1 - 3.1e-21 75.3 5.1 4e-21 75.0 5.1 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein RAP PF08373.10 AFZ81222.1 - 3.8e-07 30.1 0.1 1.1e-06 28.6 0.1 1.9 1 0 0 1 1 1 1 RAP domain Cytidylate_kin2 PF13189.6 AFZ81222.1 - 0.077 13.1 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 Cytidylate kinase-like family Phage_lysis PF03245.13 AFZ81223.1 - 0.28 11.3 7.6 0.26 11.4 2.1 3.5 2 0 0 2 2 2 0 Bacteriophage Rz lysis protein Kelch_1 PF01344.25 AFZ81224.1 - 1.2e-43 146.4 12.1 1.4e-10 40.6 0.1 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 AFZ81224.1 - 1.8e-36 123.9 12.7 2.1e-06 27.7 0.0 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 AFZ81224.1 - 4.7e-32 109.4 14.9 6.7e-09 35.5 0.2 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_2 PF07646.15 AFZ81224.1 - 1.4e-27 94.6 15.2 2.2e-07 30.6 0.2 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 AFZ81224.1 - 7.1e-26 89.6 16.9 2.3e-05 24.5 0.2 6.0 5 1 1 6 6 6 5 Kelch motif Kelch_3 PF13415.6 AFZ81224.1 - 1.8e-25 88.7 20.2 9.6e-06 25.8 0.0 7.1 7 1 0 7 7 7 6 Galactose oxidase, central domain BTB PF00651.31 AFZ81224.1 - 2.3e-18 66.5 0.3 1.8e-17 63.6 0.0 2.1 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 AFZ81224.1 - 0.089 12.9 0.1 1.1 9.3 0.0 2.3 2 0 0 2 2 2 0 BTB And C-terminal Kelch VIT1 PF01988.19 AFZ81225.1 - 7.9e-39 133.8 0.1 9.3e-39 133.5 0.1 1.0 1 0 0 1 1 1 1 VIT family DUF3131 PF11329.8 AFZ81225.1 - 0.085 11.9 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3131) DUF4131 PF13567.6 AFZ81225.1 - 0.092 12.4 0.6 15 5.2 1.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF1129 PF06570.11 AFZ81225.1 - 0.12 11.9 0.3 7.1 6.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) ATE_N PF04376.13 AFZ81225.1 - 0.19 12.2 0.1 0.35 11.3 0.1 1.4 1 0 0 1 1 1 0 Arginine-tRNA-protein transferase, N terminus RNA_pol_Rpb2_6 PF00562.28 AFZ81227.1 - 1.5e-119 399.6 0.0 2.1e-119 399.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 AFZ81227.1 - 1.7e-61 207.3 0.0 3.1e-61 206.5 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 AFZ81227.1 - 1e-46 159.0 0.0 1.6e-46 158.3 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 AFZ81227.1 - 7.7e-35 119.2 0.4 1.7e-34 118.1 0.4 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 AFZ81227.1 - 8.9e-27 93.1 0.0 2.1e-26 91.9 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.13 AFZ81227.1 - 1.2e-21 76.7 0.0 2.6e-21 75.7 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 AFZ81227.1 - 2.9e-18 66.2 2.2 2.9e-18 66.2 2.2 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 5 MRP-L47 PF06984.13 AFZ81229.1 - 3.7e-22 78.3 0.2 3.6e-21 75.1 0.0 2.1 2 0 0 2 2 2 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Seryl_tRNA_N PF02403.22 AFZ81229.1 - 0.051 13.8 4.6 0.085 13.1 4.6 1.3 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain MACPF PF01823.19 AFZ81230.1 - 4.3e-38 131.5 0.3 5.9e-38 131.1 0.3 1.2 1 0 0 1 1 1 1 MAC/Perforin domain TFIID_20kDa PF03847.13 AFZ81230.1 - 0.12 12.9 1.0 29 5.2 0.0 2.9 3 0 0 3 3 3 0 Transcription initiation factor TFIID subunit A MACPF PF01823.19 AFZ81232.1 - 2.3e-38 132.4 0.8 3.7e-38 131.7 0.8 1.3 1 0 0 1 1 1 1 MAC/Perforin domain RNA_polI_A14 PF08203.11 AFZ81232.1 - 0.16 12.7 0.6 0.53 11.0 0.1 2.2 2 0 0 2 2 2 0 Yeast RNA polymerase I subunit RPA14 RNA_pol_Rpb2_6 PF00562.28 AFZ81233.1 - 1.1e-119 400.0 0.4 1.6e-119 399.5 0.4 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 AFZ81233.1 - 4.5e-30 104.7 0.0 4.9e-30 104.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 AFZ81233.1 - 1.9e-25 88.8 0.0 4.1e-25 87.7 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.20 AFZ81233.1 - 3e-20 72.4 0.1 9.5e-20 70.8 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpa2_4 PF06883.12 AFZ81233.1 - 5e-05 23.2 0.0 0.00013 21.9 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain Zn_ribbon_SprT PF17283.2 AFZ81233.1 - 0.11 12.4 1.6 0.39 10.7 1.6 2.0 1 0 0 1 1 1 0 SprT-like zinc ribbon domain Molybdop_Fe4S4 PF04879.16 AFZ81233.1 - 8.3 6.5 8.2 3.4 7.7 0.1 2.8 3 0 0 3 3 3 0 Molybdopterin oxidoreductase Fe4S4 domain Adap_comp_sub PF00928.21 AFZ81234.1 - 1.9e-06 27.4 3.0 4e-06 26.4 3.0 1.5 1 0 0 1 1 1 1 Adaptor complexes medium subunit family PLDc_2 PF13091.6 AFZ81236.1 - 2.1e-34 118.3 0.0 4.1e-16 59.1 0.0 2.2 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 AFZ81236.1 - 2.5e-11 43.2 3.3 9.5e-05 22.4 0.9 2.8 2 0 0 2 2 2 2 Phospholipase D Active site motif SRP54 PF00448.22 AFZ81236.1 - 0.18 11.4 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain DHHC PF01529.20 AFZ81237.1 - 3.3e-37 127.6 9.7 3.3e-37 127.6 9.7 2.3 2 1 0 2 2 2 1 DHHC palmitoyltransferase SRTM1 PF15872.5 AFZ81237.1 - 0.076 13.2 0.5 0.18 11.9 0.1 1.8 1 1 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 DUF4083 PF13314.6 AFZ81237.1 - 6.7 6.7 9.1 3.1 7.8 0.3 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4083) LapA_dom PF06305.11 AFZ81237.1 - 7.1 6.5 7.3 4.1 7.3 0.0 2.8 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Slu7 PF11708.8 AFZ81238.1 - 2.3e-62 211.2 7.7 3.4e-62 210.6 7.7 1.3 1 0 0 1 1 1 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.6 AFZ81238.1 - 0.019 14.7 0.2 0.044 13.5 0.2 1.7 1 0 0 1 1 1 0 Zinc knuckle DUF386 PF04074.12 AFZ81238.1 - 0.026 14.5 0.2 0.055 13.4 0.2 1.5 1 0 0 1 1 1 0 YhcH/YjgK/YiaL Ribosomal_L19 PF01245.20 AFZ81239.1 - 1.5e-13 50.6 0.0 1.5e-13 50.6 0.0 2.9 3 0 0 3 3 3 1 Ribosomal protein L19 TPR_2 PF07719.17 AFZ81240.1 - 1.1e-13 50.2 0.5 0.031 14.4 0.0 6.5 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 AFZ81240.1 - 1.8e-12 47.6 0.1 7.4e-05 23.2 0.0 5.0 5 1 0 5 5 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 AFZ81240.1 - 8.5e-10 38.3 1.5 0.089 13.2 0.0 6.4 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 AFZ81240.1 - 3.5e-09 36.1 3.0 0.019 14.8 0.1 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 AFZ81240.1 - 6.9e-08 32.7 0.0 1.8 9.6 0.0 5.7 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 AFZ81240.1 - 7.4e-08 32.0 3.8 0.17 12.2 0.1 6.9 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 AFZ81240.1 - 1.5e-06 28.4 0.1 0.15 12.4 0.0 5.4 5 1 0 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 AFZ81240.1 - 1.2e-05 25.6 0.0 1 10.1 0.0 5.1 5 0 0 5 5 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 AFZ81240.1 - 1.6e-05 25.0 1.5 0.24 11.7 0.2 5.0 4 1 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 AFZ81240.1 - 6.4e-05 23.0 0.0 0.67 10.1 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF3808 PF10300.9 AFZ81240.1 - 0.00047 19.0 0.1 0.0029 16.4 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3808) TPR_7 PF13176.6 AFZ81240.1 - 0.00082 19.2 0.0 47 4.3 0.0 5.9 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 AFZ81240.1 - 0.01 15.5 0.0 10 5.9 0.0 4.8 6 0 0 6 6 6 0 TPR repeat ChAPs PF09295.10 AFZ81240.1 - 0.052 12.6 2.4 6.8 5.6 0.0 3.4 3 1 1 4 4 4 0 ChAPs (Chs5p-Arf1p-binding proteins) ATP13 PF12921.7 AFZ81240.1 - 0.066 13.1 0.1 0.61 10.0 0.0 2.7 2 0 0 2 2 2 0 Mitochondrial ATPase expression PPR PF01535.20 AFZ81240.1 - 0.17 12.2 0.5 38 4.8 0.1 3.6 3 0 0 3 3 2 0 PPR repeat TPR_3 PF07720.12 AFZ81240.1 - 0.93 9.6 3.8 32 4.7 0.2 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Histone_H2A_C PF16211.5 AFZ81241.1 - 4.5e-17 61.5 0.3 8.2e-17 60.7 0.3 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 AFZ81241.1 - 4.1e-15 56.3 0.0 5.4e-15 55.9 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 AFZ81241.1 - 0.00051 20.3 0.0 0.00086 19.5 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 AFZ81242.1 - 2.5e-54 183.1 1.7 2.8e-54 183.0 1.7 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 AFZ81242.1 - 0.00041 20.4 0.3 0.00077 19.6 0.0 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 AFZ81242.1 - 0.00044 20.6 0.0 0.00069 20.0 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 AFZ81242.1 - 0.00054 20.5 1.7 0.00069 20.2 1.7 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 AFZ81242.1 - 0.0058 16.9 0.9 0.01 16.1 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 AFZ81242.1 - 0.017 15.2 0.1 0.031 14.3 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit TMA7 PF09072.10 AFZ81242.1 - 0.069 14.0 2.3 0.12 13.2 2.3 1.4 1 0 0 1 1 1 0 Translation machinery associated TMA7 PTH2 PF01981.16 AFZ81243.1 - 2.3e-16 60.1 0.0 2.7e-16 59.9 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 PWI PF01480.17 AFZ81244.1 - 1.5e-11 44.4 1.5 5.9e-11 42.5 0.2 2.4 2 0 0 2 2 2 1 PWI domain RRM_1 PF00076.22 AFZ81244.1 - 1.1e-08 34.8 0.0 3e-08 33.3 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Relaxase PF03432.14 AFZ81245.1 - 0.051 13.2 6.0 0.17 11.5 4.3 2.1 2 0 0 2 2 2 0 Relaxase/Mobilisation nuclease domain RRM_1 PF00076.22 AFZ81246.1 - 5.1e-17 61.5 0.0 7.8e-17 60.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Shikimate_dh_N PF08501.11 AFZ81246.1 - 0.23 11.7 0.0 0.43 10.9 0.0 1.4 1 0 0 1 1 1 0 Shikimate dehydrogenase substrate binding domain Ribosomal_L22e PF01776.17 AFZ81247.1 - 5.6e-45 152.2 1.2 7e-45 151.9 1.2 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family FAD_SOX PF18371.1 AFZ81247.1 - 0.023 15.0 0.4 2.5 8.5 0.1 2.2 2 0 0 2 2 2 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase RPN7 PF10602.9 AFZ81248.1 - 2.1e-50 170.8 0.2 4.6e-50 169.7 0.2 1.6 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 AFZ81248.1 - 1.2e-14 54.7 0.5 3.6e-14 53.1 0.2 2.0 2 0 0 2 2 2 1 PCI domain TPR_8 PF13181.6 AFZ81248.1 - 0.01 15.9 0.2 0.01 15.9 0.2 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 AFZ81248.1 - 0.037 13.9 0.3 0.084 12.7 0.3 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.6 AFZ81248.1 - 0.038 14.0 0.0 0.11 12.6 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 AFZ81248.1 - 0.11 12.6 0.1 0.38 11.0 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat Pkinase PF00069.25 AFZ81249.1 - 3e-45 154.7 0.0 4.1e-45 154.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ81249.1 - 9.3e-16 57.9 0.0 1.5e-15 57.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AFZ81249.1 - 1.1e-08 34.3 0.0 2.1e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 AFZ81249.1 - 5.6e-06 25.9 0.0 9.6e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AFZ81249.1 - 0.00075 19.5 0.0 0.007 16.3 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 AFZ81249.1 - 0.065 12.2 0.1 0.1 11.6 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase EF-hand_6 PF13405.6 AFZ81250.1 - 1.3e-09 37.2 7.7 1.6e-06 27.6 0.3 4.2 3 1 1 4 4 4 1 EF-hand domain EF-hand_7 PF13499.6 AFZ81250.1 - 3.5e-09 37.0 8.3 7.7e-06 26.3 2.9 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 AFZ81250.1 - 1.5e-08 33.6 11.1 1.7e-06 27.2 0.5 4.1 4 1 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 AFZ81250.1 - 0.0004 20.2 10.4 0.36 10.7 0.8 4.4 1 1 4 5 5 5 3 EF-hand domain pair Caleosin PF05042.13 AFZ81250.1 - 0.0023 17.9 1.5 2.6 8.0 0.0 3.2 1 1 2 3 3 3 2 Caleosin related protein ComFB PF10719.9 AFZ81250.1 - 0.017 15.2 0.0 0.18 11.9 0.0 2.0 2 0 0 2 2 2 0 Late competence development protein ComFB EF-hand_5 PF13202.6 AFZ81250.1 - 0.49 10.0 3.7 1.4 8.5 0.3 3.4 3 0 0 3 3 3 0 EF hand Ribosomal_S4e PF00900.20 AFZ81251.1 - 9.8e-32 108.7 0.5 2.8e-31 107.2 0.1 1.9 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.5 AFZ81251.1 - 7.8e-20 70.3 0.0 1.3e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 AFZ81251.1 - 4.7e-19 68.2 7.2 4.7e-19 68.2 7.2 1.9 2 0 0 2 2 2 1 RS4NT (NUC023) domain KOW PF00467.29 AFZ81251.1 - 6.2e-06 26.0 1.4 6.2e-06 26.0 1.4 2.7 3 0 0 3 3 3 1 KOW motif S4 PF01479.25 AFZ81251.1 - 9.1e-06 25.3 0.1 2e-05 24.2 0.1 1.6 1 0 0 1 1 1 1 S4 domain Sipho_tail PF05709.11 AFZ81251.1 - 0.0064 15.9 0.0 0.01 15.3 0.0 1.3 1 0 0 1 1 1 1 Phage tail protein EF-hand_7 PF13499.6 AFZ81252.1 - 7.8e-25 87.1 5.7 4e-11 43.2 0.0 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 AFZ81252.1 - 2e-24 83.3 13.4 8.2e-06 25.0 0.1 5.4 5 0 0 5 5 5 5 EF hand EF-hand_5 PF13202.6 AFZ81252.1 - 3.8e-23 79.9 15.2 6.8e-08 31.7 0.1 5.3 5 0 0 5 5 5 5 EF hand EF-hand_6 PF13405.6 AFZ81252.1 - 2.2e-21 73.9 10.6 3.6e-06 26.5 0.0 5.4 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.6 AFZ81252.1 - 5.8e-10 38.9 9.6 7.5e-05 22.5 0.0 5.2 5 0 0 5 5 5 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 AFZ81252.1 - 3.3e-07 30.6 2.0 0.22 11.8 0.0 3.2 2 1 1 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 AFZ81252.1 - 0.0073 16.5 8.1 1.8 8.8 0.8 3.8 3 1 1 4 4 4 3 Dockerin type I domain YkyA PF10368.9 AFZ81252.1 - 0.021 14.5 1.1 0.034 13.8 1.1 1.3 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein DUF1007 PF06226.13 AFZ81252.1 - 0.03 14.3 0.4 7.6 6.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1007) ABC_ATPase PF09818.9 AFZ81254.1 - 2.2e-166 554.1 0.0 2.9e-166 553.7 0.0 1.1 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA_23 PF13476.6 AFZ81254.1 - 5.6e-05 23.7 1.6 0.00037 21.1 1.6 2.4 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 AFZ81254.1 - 0.0061 16.1 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 AFZ81254.1 - 0.14 11.9 0.1 0.29 10.9 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Glu_cys_ligase PF04262.14 AFZ81255.1 - 0.026 13.1 0.4 0.03 13.0 0.4 1.0 1 0 0 1 1 1 0 Glutamate-cysteine ligase DUF4474 PF14751.6 AFZ81255.1 - 0.13 11.7 1.4 0.13 11.6 1.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4474) DEAD PF00270.29 AFZ81256.1 - 1.3e-15 57.6 0.0 3.2e-10 40.1 0.0 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 AFZ81256.1 - 1.8e-15 57.2 0.0 5.7e-15 55.6 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AFZ81256.1 - 0.0096 15.9 0.0 0.78 9.7 0.0 3.0 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Ribosomal_S15 PF00312.22 AFZ81258.1 - 1.9e-24 85.7 1.6 5.7e-24 84.1 1.6 1.9 1 0 0 1 1 1 1 Ribosomal protein S15 Tropomyosin_1 PF12718.7 AFZ81258.1 - 0.011 15.9 0.5 0.029 14.5 0.5 1.7 1 0 0 1 1 1 0 Tropomyosin like DUF4972 PF16342.5 AFZ81258.1 - 0.017 14.8 0.1 0.11 12.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4972) Gpi16 PF04113.14 AFZ81259.1 - 2.6e-20 72.4 1.2 5.4e-11 41.6 0.0 3.0 3 0 0 3 3 3 3 Gpi16 subunit, GPI transamidase component RNA_pol_Rpb1_5 PF04998.17 AFZ81260.1 - 3.7e-87 292.1 0.1 8.2e-87 291.0 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 AFZ81260.1 - 5.8e-75 252.5 4.6 9.7e-75 251.8 4.6 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 AFZ81260.1 - 4.5e-70 235.2 0.0 1.2e-69 233.7 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 AFZ81260.1 - 3.6e-32 111.5 0.0 1.6e-31 109.4 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 AFZ81260.1 - 5.4e-30 103.5 0.0 1.7e-29 101.9 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 zinc_ribbon_15 PF17032.5 AFZ81260.1 - 0.34 11.7 4.8 1.1 10.0 4.8 1.9 1 0 0 1 1 1 0 zinc-ribbon family HSP90 PF00183.18 AFZ81262.1 - 1.2e-145 486.4 8.3 3e-144 481.7 8.3 2.1 1 1 0 1 1 1 1 Hsp90 protein HATPase_c_3 PF13589.6 AFZ81262.1 - 5.5e-11 42.4 0.0 1.3e-10 41.3 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 AFZ81262.1 - 4.7e-10 40.0 0.0 1.3e-09 38.5 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Pkinase PF00069.25 AFZ81263.1 - 5.6e-41 140.6 0.0 6.1e-23 81.5 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ81263.1 - 1.4e-12 47.5 0.0 0.00011 21.6 0.0 3.3 2 1 0 2 2 2 2 Protein tyrosine kinase Ras PF00071.22 AFZ81264.1 - 1.3e-58 197.2 0.1 1.5e-58 197.0 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AFZ81264.1 - 8.9e-35 119.5 0.1 1.3e-34 119.0 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AFZ81264.1 - 2.5e-16 59.6 0.0 3e-16 59.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 AFZ81264.1 - 9.2e-06 25.7 0.0 1.3e-05 25.2 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AFZ81264.1 - 4.2e-05 23.5 0.3 0.066 13.1 0.1 2.3 1 1 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 AFZ81264.1 - 0.00034 20.2 0.0 0.059 12.9 0.0 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B Gtr1_RagA PF04670.12 AFZ81264.1 - 0.00068 19.1 0.0 0.0013 18.1 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 AFZ81264.1 - 0.0016 17.9 0.1 0.0019 17.6 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 AFZ81264.1 - 0.0044 16.6 0.2 0.026 14.0 0.1 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 AFZ81264.1 - 0.012 16.0 0.0 0.016 15.6 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain CENP-M PF11111.8 AFZ81264.1 - 0.032 13.4 0.0 0.047 12.9 0.0 1.2 1 0 0 1 1 1 0 Centromere protein M (CENP-M) AAA_22 PF13401.6 AFZ81264.1 - 0.049 13.9 0.0 0.085 13.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 AFZ81264.1 - 0.073 12.5 0.0 0.68 9.3 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein ABC_tran PF00005.27 AFZ81264.1 - 0.092 13.3 0.0 0.14 12.7 0.0 1.4 1 1 0 1 1 1 0 ABC transporter GATA PF00320.27 AFZ81265.1 - 1.3e-07 31.0 2.3 2.6e-07 30.1 2.3 1.5 1 0 0 1 1 1 1 GATA zinc finger ArfGap PF01412.18 AFZ81265.1 - 0.0091 16.1 0.5 0.026 14.6 0.5 1.7 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf OTU PF02338.19 AFZ81267.1 - 0.053 14.0 0.1 12 6.5 0.0 2.5 2 1 0 2 2 2 0 OTU-like cysteine protease Sec1 PF00995.23 AFZ81268.1 - 2.2e-64 218.7 8.2 2.9e-64 218.3 8.2 1.0 1 0 0 1 1 1 1 Sec1 family D123 PF07065.14 AFZ81269.1 - 4.5e-29 101.6 6.9 4.1e-27 95.1 6.9 2.3 1 1 0 1 1 1 1 D123 Fe-S_biosyn PF01521.20 AFZ81270.1 - 1.9e-11 44.2 0.0 2.4e-11 43.8 0.0 1.1 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis OPA3 PF07047.12 AFZ81272.1 - 8.8e-10 38.4 0.0 1.2e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) DUF3429 PF11911.8 AFZ81273.1 - 0.014 15.7 2.3 0.018 15.3 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3429) AAA PF00004.29 AFZ81274.1 - 6.7e-09 36.3 0.0 1.8e-08 34.9 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 AFZ81274.1 - 2.9e-08 33.9 0.1 7.3e-08 32.5 0.1 1.7 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_18 PF13238.6 AFZ81274.1 - 9.7e-06 26.2 1.2 0.00022 21.8 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_16 PF13191.6 AFZ81274.1 - 0.00011 22.6 0.0 0.00026 21.4 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 AFZ81274.1 - 0.00017 21.7 0.1 0.00057 20.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 AFZ81274.1 - 0.00031 20.8 0.0 0.00099 19.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 AFZ81274.1 - 0.0012 18.8 0.0 0.0038 17.1 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase Zeta_toxin PF06414.12 AFZ81274.1 - 0.0016 17.7 0.0 0.0035 16.7 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_14 PF13173.6 AFZ81274.1 - 0.002 18.2 0.0 0.0073 16.3 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 AFZ81274.1 - 0.0023 18.2 0.0 0.0047 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 AFZ81274.1 - 0.0032 17.2 0.0 0.0065 16.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Terpene_synth PF01397.21 AFZ81274.1 - 0.0042 16.8 0.0 0.009 15.7 0.0 1.7 1 0 0 1 1 1 1 Terpene synthase, N-terminal domain dNK PF01712.19 AFZ81274.1 - 0.0048 16.8 0.1 0.13 12.1 0.1 2.5 1 1 0 1 1 1 1 Deoxynucleoside kinase TsaE PF02367.17 AFZ81274.1 - 0.012 15.6 0.0 0.025 14.6 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 AFZ81274.1 - 0.012 15.8 0.0 0.03 14.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 AFZ81274.1 - 0.021 14.6 0.0 0.34 10.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_6 PF12774.7 AFZ81274.1 - 0.031 13.2 0.0 0.09 11.7 0.0 1.8 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region ABC_tran PF00005.27 AFZ81274.1 - 0.036 14.6 0.0 0.13 12.8 0.0 1.9 1 0 0 1 1 1 0 ABC transporter AAA_17 PF13207.6 AFZ81274.1 - 0.038 14.4 1.9 0.16 12.4 0.1 2.8 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 AFZ81274.1 - 0.046 13.3 0.0 0.095 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 AFZ81274.1 - 0.051 13.5 0.0 0.16 11.9 0.0 1.8 1 0 0 1 1 1 0 NTPase AAA_19 PF13245.6 AFZ81274.1 - 0.052 13.9 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 AFZ81274.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain PAP2_C PF14360.6 AFZ81275.1 - 1.1e-15 58.0 16.2 1.1e-15 58.0 16.2 3.1 3 0 0 3 3 3 1 PAP2 superfamily C-terminal PAP2 PF01569.21 AFZ81275.1 - 1.4e-06 28.2 8.5 1.4e-06 28.2 8.5 1.8 1 1 1 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 AFZ81275.1 - 0.0011 18.7 10.1 0.0011 18.7 10.1 2.0 2 1 0 2 2 2 1 PAP2 superfamily Mito_carr PF00153.27 AFZ81276.1 - 5e-07 29.6 0.2 0.00076 19.3 0.0 2.4 2 0 0 2 2 2 2 Mitochondrial carrier protein TMEM169 PF15052.6 AFZ81276.1 - 0.64 10.1 5.1 0.94 9.6 0.1 2.7 2 1 1 3 3 3 0 TMEM169 protein family PA14 PF07691.12 AFZ81278.1 - 2.8e-22 79.1 0.0 6.7e-22 77.9 0.0 1.7 1 0 0 1 1 1 1 PA14 domain fn2 PF00040.19 AFZ81278.1 - 0.00073 19.8 1.1 0.0023 18.2 1.1 2.0 1 0 0 1 1 1 1 Fibronectin type II domain LCCL PF03815.19 AFZ81278.1 - 0.006 16.7 0.3 0.006 16.7 0.3 2.1 2 0 0 2 2 2 1 LCCL domain DUF3573 PF12097.8 AFZ81278.1 - 0.092 11.5 0.4 0.17 10.7 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) MHC_II_beta PF00969.19 AFZ81278.1 - 0.21 11.7 0.8 21 5.3 0.0 3.0 3 0 0 3 3 3 0 Class II histocompatibility antigen, beta domain CENP-H PF05837.12 AFZ81278.1 - 2.4 8.6 7.9 4.4 7.7 7.9 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) ITI_HC_C PF06668.12 AFZ81279.1 - 0.011 15.4 0.0 0.021 14.4 0.0 1.5 1 0 0 1 1 1 0 Inter-alpha-trypsin inhibitor heavy chain C-terminus ABC_tran PF00005.27 AFZ81281.1 - 2.9e-31 108.8 0.0 2.1e-17 63.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 AFZ81281.1 - 4.1e-06 26.8 1.1 0.13 12.0 0.0 3.3 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 AFZ81281.1 - 2e-05 24.3 0.8 0.058 13.1 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 AFZ81281.1 - 2.6e-05 24.7 0.0 0.044 14.2 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.6 AFZ81281.1 - 0.00044 20.0 0.1 0.36 10.5 0.0 2.3 2 0 0 2 2 2 2 AAA domain DnaB_C PF03796.15 AFZ81281.1 - 0.00093 18.6 0.0 0.12 11.7 0.0 2.3 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_18 PF13238.6 AFZ81281.1 - 0.00095 19.7 0.2 2.2 8.9 0.1 2.5 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 AFZ81281.1 - 0.00097 19.1 0.8 0.09 12.7 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase Zeta_toxin PF06414.12 AFZ81281.1 - 0.0011 18.3 0.2 0.46 9.7 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_23 PF13476.6 AFZ81281.1 - 0.0013 19.3 5.5 0.68 10.4 0.3 2.7 2 0 0 2 2 2 2 AAA domain DUF87 PF01935.17 AFZ81281.1 - 0.0041 17.2 2.0 0.097 12.7 0.1 2.4 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_22 PF13401.6 AFZ81281.1 - 0.0072 16.6 0.1 1.2 9.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 AFZ81281.1 - 0.01 15.9 0.2 0.19 11.8 0.1 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_15 PF13175.6 AFZ81281.1 - 0.011 15.4 2.3 2.6 7.6 0.0 2.8 3 0 0 3 3 3 0 AAA ATPase domain SMC_N PF02463.19 AFZ81281.1 - 0.014 14.9 0.9 0.21 11.0 0.1 2.6 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain NACHT PF05729.12 AFZ81281.1 - 0.014 15.3 0.5 3 7.8 0.1 2.6 2 0 0 2 2 2 0 NACHT domain FtsK_SpoIIIE PF01580.18 AFZ81281.1 - 0.018 14.4 1.0 1.8 7.9 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family cobW PF02492.19 AFZ81281.1 - 0.029 13.9 0.5 6.8 6.2 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.20 AFZ81281.1 - 0.031 13.3 0.7 6.5 5.7 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein SbcCD_C PF13558.6 AFZ81281.1 - 0.033 14.4 0.0 0.075 13.3 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit MeaB PF03308.16 AFZ81281.1 - 0.034 13.1 0.7 0.07 12.1 0.1 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 AFZ81281.1 - 0.054 13.6 0.7 8.5 6.4 0.1 2.5 2 0 0 2 2 2 0 Dynamin family ATP_bind_1 PF03029.17 AFZ81281.1 - 0.065 13.0 0.1 8.7 6.0 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_25 PF13481.6 AFZ81281.1 - 0.069 12.7 0.0 1.8 8.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 AFZ81281.1 - 0.098 11.8 0.5 1.9 7.6 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain TrwB_AAD_bind PF10412.9 AFZ81281.1 - 0.13 11.1 0.2 4.3 6.2 0.0 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain NTPase_1 PF03266.15 AFZ81281.1 - 0.14 12.1 0.2 7.3 6.5 0.1 2.4 2 0 0 2 2 2 0 NTPase TsaE PF02367.17 AFZ81281.1 - 0.18 11.8 0.6 3.2 7.8 0.1 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NUDIX_2 PF13869.6 AFZ81282.1 - 3e-42 144.3 0.0 3.6e-42 144.1 0.0 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase Acetyltransf_1 PF00583.25 AFZ81285.1 - 8.7e-15 55.0 0.1 1.1e-14 54.7 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AFZ81285.1 - 6.1e-10 39.1 0.0 6.5e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AFZ81285.1 - 7.6e-10 39.1 0.1 1e-09 38.7 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AFZ81285.1 - 4.8e-07 29.6 0.0 9.8e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 AFZ81285.1 - 0.00032 20.9 0.4 0.00043 20.4 0.4 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 AFZ81285.1 - 0.011 15.7 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain PanZ PF12568.8 AFZ81285.1 - 0.015 15.0 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_13 PF13880.6 AFZ81285.1 - 0.054 13.5 0.0 0.09 12.8 0.0 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase TBCA PF02970.16 AFZ81286.1 - 4.5e-15 55.7 2.2 5.2e-15 55.5 2.2 1.1 1 0 0 1 1 1 1 Tubulin binding cofactor A T6PP_N PF18572.1 AFZ81286.1 - 0.063 13.1 0.4 0.088 12.7 0.3 1.4 1 1 0 1 1 1 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain tRNA-synt_2d PF01409.20 AFZ81287.1 - 4.9e-78 262.0 0.0 7e-78 261.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 AFZ81287.1 - 8.1e-07 29.2 0.1 2.1e-06 27.9 0.1 1.7 1 0 0 1 1 1 1 PheRS DNA binding domain 3 tRNA_synthFbeta PF17759.1 AFZ81287.1 - 1.6e-05 24.5 0.0 3e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 AFZ81287.1 - 0.0052 15.9 0.0 0.018 14.1 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) PheRS_DBD2 PF18554.1 AFZ81287.1 - 0.017 15.1 1.6 0.067 13.2 0.7 2.3 2 0 0 2 2 2 0 PheRS DNA binding domain 2 PheRS_DBD1 PF18552.1 AFZ81287.1 - 0.037 13.8 0.1 0.21 11.4 0.0 2.3 3 0 0 3 3 3 0 PheRS DNA binding domain 1 Cas9_C PF18525.1 AFZ81287.1 - 0.057 13.6 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 Cas9 C-terminal domain Mre11_DNA_bind PF04152.14 AFZ81288.1 - 2.3e-22 80.1 1.9 3.4e-22 79.6 0.3 2.1 2 0 0 2 2 2 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 AFZ81288.1 - 2.3e-15 57.7 3.4 4e-15 56.9 3.4 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 AFZ81288.1 - 1.5e-05 25.2 0.0 0.00021 21.5 0.0 2.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain AT_hook PF02178.19 AFZ81288.1 - 0.029 14.2 2.4 0.066 13.1 2.4 1.6 1 0 0 1 1 1 0 AT hook motif TatD_DNase PF01026.21 AFZ81288.1 - 0.077 12.4 0.0 0.22 10.8 0.0 1.7 1 0 0 1 1 1 0 TatD related DNase Iso_dh PF00180.20 AFZ81289.1 - 2.8e-66 224.0 0.0 3.5e-66 223.7 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Proteasome PF00227.26 AFZ81291.1 - 1.8e-35 122.1 0.0 7.3e-35 120.2 0.0 1.7 1 1 0 1 1 1 1 Proteasome subunit TMF_DNA_bd PF12329.8 AFZ81292.1 - 0.002 18.1 3.0 0.002 18.1 3.0 3.6 1 1 4 5 5 5 1 TATA element modulatory factor 1 DNA binding PKcGMP_CC PF16808.5 AFZ81292.1 - 0.0032 17.3 0.0 0.0032 17.3 0.0 4.6 5 1 1 6 6 6 1 Coiled-coil N-terminus of cGMP-dependent protein kinase CDT1 PF08839.11 AFZ81292.1 - 0.014 15.7 1.2 0.019 15.2 0.5 1.6 1 1 0 1 1 1 0 DNA replication factor CDT1 like ALMT PF11744.8 AFZ81292.1 - 1 8.1 9.4 1.2 7.9 9.4 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF641 PF04859.12 AFZ81292.1 - 3.4 8.0 13.9 14 6.1 6.4 2.8 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) SlyX PF04102.12 AFZ81292.1 - 8.1 7.1 16.1 4.6 7.9 0.9 3.9 2 1 1 4 4 4 0 SlyX DUF1672 PF07901.11 AFZ81292.1 - 8.7 5.6 8.8 5.3 6.3 6.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1672) Tmemb_14 PF03647.13 AFZ81293.1 - 1.5e-05 25.6 8.5 3.3e-05 24.5 8.5 1.7 1 1 0 1 1 1 1 Transmembrane proteins 14C DUF2070 PF09843.9 AFZ81293.1 - 5.7 5.1 11.0 6.5 4.9 11.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) PIG-L PF02585.17 AFZ81294.1 - 2.6e-14 53.9 0.0 5.2e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase SNF2_N PF00176.23 AFZ81295.1 - 6.4e-48 163.2 0.1 1.8e-47 161.8 0.1 1.7 1 1 0 1 1 1 1 SNF2 family N-terminal domain PHD PF00628.29 AFZ81295.1 - 2.4e-22 78.6 69.0 1.5e-10 40.8 7.0 7.2 6 1 0 6 6 6 4 PHD-finger Helicase_C PF00271.31 AFZ81295.1 - 6.5e-15 55.4 0.0 3.2e-14 53.2 0.0 2.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AFZ81295.1 - 1.6e-07 31.5 2.1 1.3e-06 28.6 0.0 3.6 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit DEAD PF00270.29 AFZ81295.1 - 3.3e-05 23.7 0.0 0.00085 19.1 0.0 2.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase zf-PHD-like PF15446.6 AFZ81295.1 - 0.0002 21.0 43.2 0.002 17.8 0.8 7.2 6 1 1 7 7 7 4 PHD/FYVE-zinc-finger like domain PHD_2 PF13831.6 AFZ81295.1 - 0.00042 19.8 2.0 0.00042 19.8 2.0 8.0 8 0 0 8 8 8 2 PHD-finger C1_1 PF00130.22 AFZ81295.1 - 0.0035 17.2 0.9 0.0035 17.2 0.9 7.9 6 2 1 7 7 7 3 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 AFZ81295.1 - 0.004 17.1 1.1 0.004 17.1 1.1 7.6 7 1 0 7 7 7 2 Prokaryotic RING finger family 1 AAA_14 PF13173.6 AFZ81295.1 - 0.044 13.8 0.6 0.89 9.6 0.0 2.8 2 0 0 2 2 2 0 AAA domain GTP_EFTU PF00009.27 AFZ81296.1 - 2e-31 109.1 0.0 3.6e-31 108.2 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 AFZ81296.1 - 0.00097 19.2 0.0 0.0025 17.9 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 AFZ81296.1 - 0.0072 15.6 0.1 0.021 14.1 0.0 1.8 2 0 0 2 2 2 1 Septin FTCD PF02971.14 AFZ81296.1 - 0.03 14.4 0.0 0.12 12.4 0.0 1.9 2 0 0 2 2 2 0 Formiminotransferase domain Dynamin_N PF00350.23 AFZ81296.1 - 0.22 11.6 4.9 0.75 9.8 0.1 2.7 2 1 1 3 3 3 0 Dynamin family Nop52 PF05997.12 AFZ81297.1 - 6.6e-44 150.3 5.9 1.3e-43 149.3 5.9 1.5 1 0 0 1 1 1 1 Nucleolar protein,Nop52 TAN PF11640.8 AFZ81297.1 - 0.0019 18.4 0.3 0.013 15.7 0.0 2.6 2 1 1 3 3 3 1 Telomere-length maintenance and DNA damage repair MOLO1 PF17175.4 AFZ81297.1 - 0.17 12.0 0.7 1.2 9.3 0.1 2.5 2 1 0 2 2 2 0 Modulator of levamisole receptor-1 NifU PF01106.17 AFZ81298.1 - 3.5e-24 84.7 0.1 4.8e-24 84.3 0.1 1.2 1 0 0 1 1 1 1 NifU-like domain Ank_2 PF12796.7 AFZ81299.1 - 6.9e-40 135.5 0.3 1.4e-17 64.0 0.6 5.4 1 1 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 AFZ81299.1 - 3.4e-31 107.2 4.7 2e-09 37.8 0.0 7.2 3 1 4 7 7 7 4 Ankyrin repeats (many copies) Ank PF00023.30 AFZ81299.1 - 5.7e-27 93.0 2.6 1.8e-05 24.9 0.0 7.5 7 0 0 7 7 7 6 Ankyrin repeat Ank_3 PF13606.6 AFZ81299.1 - 9.6e-26 87.0 5.1 0.00016 21.8 0.0 9.1 9 0 0 9 9 9 6 Ankyrin repeat Ank_5 PF13857.6 AFZ81299.1 - 3.2e-23 81.5 1.1 7.3e-06 26.2 0.0 6.0 4 1 3 7 7 7 4 Ankyrin repeats (many copies) Kelch_4 PF13418.6 AFZ81300.1 - 1.1e-31 108.5 11.0 5.3e-09 36.0 0.0 6.9 5 2 1 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 AFZ81300.1 - 4.3e-24 84.3 8.4 6e-08 32.8 0.0 7.5 7 1 0 7 7 7 4 Galactose oxidase, central domain Kelch_6 PF13964.6 AFZ81300.1 - 4.1e-22 77.7 8.8 4.5e-11 42.6 0.0 6.4 4 2 2 6 6 6 4 Kelch motif Kelch_5 PF13854.6 AFZ81300.1 - 1.4e-19 69.6 7.8 2.5e-06 27.3 0.1 6.4 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 AFZ81300.1 - 2e-11 43.4 8.4 0.0018 18.1 0.1 5.8 6 0 0 6 6 6 3 Kelch motif Kelch_1 PF01344.25 AFZ81300.1 - 2.2e-10 40.0 8.7 0.002 17.7 0.0 5.9 6 0 0 6 6 6 3 Kelch motif DUF4110 PF13422.6 AFZ81300.1 - 2.6e-08 33.8 0.4 6.1e-08 32.6 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4110) PK PF00224.21 AFZ81301.1 - 2.5e-139 464.0 0.7 2.5e-139 464.0 0.7 1.4 2 0 0 2 2 2 1 Pyruvate kinase, barrel domain PK_C PF02887.16 AFZ81301.1 - 5.8e-27 94.3 0.3 5.8e-27 94.3 0.3 1.9 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 AFZ81301.1 - 0.0088 15.2 0.1 0.018 14.2 0.1 1.5 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PEPcase_2 PF14010.6 AFZ81301.1 - 0.054 12.0 0.1 0.097 11.2 0.1 1.4 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase NUDIX PF00293.28 AFZ81302.1 - 0.0074 16.3 0.0 0.016 15.3 0.0 1.6 1 1 0 1 1 1 1 NUDIX domain MRP-L46 PF11788.8 AFZ81302.1 - 0.15 12.8 2.2 0.29 11.9 1.0 2.1 1 1 1 2 2 2 0 39S mitochondrial ribosomal protein L46 RNase_PH PF01138.21 AFZ81303.1 - 3e-10 40.7 0.3 5.9e-10 39.8 0.3 1.5 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 AFZ81303.1 - 2.1e-05 24.5 0.2 4.7e-05 23.3 0.2 1.7 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 AP2 PF00847.20 AFZ81304.1 - 2e-07 31.1 4.6 3.4e-07 30.4 4.6 1.4 1 0 0 1 1 1 1 AP2 domain UCR_UQCRX_QCR9 PF05365.12 AFZ81305.1 - 5.9e-12 45.3 0.4 1.2e-11 44.4 0.2 1.5 2 0 0 2 2 2 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like RAP PF08373.10 AFZ81306.1 - 1.1e-10 41.5 1.2 3.4e-10 39.8 1.2 2.0 1 0 0 1 1 1 1 RAP domain FAST_1 PF06743.15 AFZ81306.1 - 0.0022 17.9 4.7 1.7 8.6 0.1 4.3 3 1 1 4 4 4 2 FAST kinase-like protein, subdomain 1 FAST_1 PF06743.15 AFZ81307.1 - 0.57 10.2 8.7 43 4.1 0.0 5.7 4 2 2 6 6 6 0 FAST kinase-like protein, subdomain 1 Fe-S_biosyn PF01521.20 AFZ81308.1 - 8.7e-13 48.4 0.1 1.1e-12 48.1 0.1 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis BLM10_mid PF16507.5 AFZ81310.1 - 1.1e-49 169.5 7.1 2.9e-49 168.1 7.1 1.7 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 AFZ81310.1 - 7e-22 77.2 0.0 3.3e-21 75.0 0.0 2.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) AWPM-19 PF05512.11 AFZ81310.1 - 0.061 13.5 0.0 0.22 11.7 0.0 1.9 2 0 0 2 2 2 0 AWPM-19-like family HTH_Tnp_4 PF13613.6 AFZ81310.1 - 0.12 12.1 0.2 0.38 10.5 0.2 1.8 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease Cullin PF00888.22 AFZ81311.1 - 4.3e-45 154.5 9.1 5.1e-45 154.2 9.1 1.1 1 0 0 1 1 1 1 Cullin family OHA PF14418.6 AFZ81311.1 - 0.058 13.2 0.0 0.19 11.6 0.0 1.9 1 0 0 1 1 1 0 OST-HTH Associated domain ERp29 PF07749.12 AFZ81311.1 - 0.39 11.6 5.0 0.7 10.8 0.3 2.9 3 1 0 3 3 3 0 Endoplasmic reticulum protein ERp29, C-terminal domain Cullin PF00888.22 AFZ81312.1 - 3.9e-15 55.5 0.9 4.5e-15 55.3 0.9 1.1 1 0 0 1 1 1 1 Cullin family Cullin PF00888.22 AFZ81313.1 - 2.9e-15 55.9 0.1 3.4e-15 55.7 0.1 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 AFZ81313.1 - 4.4e-05 23.4 0.1 0.00012 22.0 0.1 1.7 1 0 0 1 1 1 1 Cullin protein neddylation domain UvrB_inter PF17757.1 AFZ81313.1 - 0.097 12.9 0.3 0.21 11.8 0.3 1.5 1 0 0 1 1 1 0 UvrB interaction domain Mito_carr PF00153.27 AFZ81314.1 - 2.9e-31 107.2 1.4 2.3e-10 40.3 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein tRNA-synt_1 PF00133.22 AFZ81315.1 - 2e-37 128.7 0.2 6.3e-21 74.3 0.0 3.7 1 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 AFZ81315.1 - 2.4e-19 69.3 0.2 4.7e-09 35.5 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 AFZ81315.1 - 3.9e-14 52.9 3.3 9.1e-14 51.7 3.3 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 AFZ81315.1 - 1.3e-09 37.9 0.0 3.5e-09 36.5 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 AFZ81315.1 - 0.0053 15.7 0.1 0.077 11.9 0.0 2.5 2 0 0 2 2 2 1 tRNA synthetases class I (K) DUF647 PF04884.14 AFZ81316.1 - 3.1e-30 105.6 2.4 1.1e-29 103.7 2.4 1.8 1 1 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis DNA_pol3_a_NII PF11490.8 AFZ81316.1 - 0.074 12.9 0.6 9.7 6.1 0.4 2.7 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II RGCC PF15151.6 AFZ81316.1 - 0.31 11.2 3.3 4.5 7.5 0.7 2.5 2 0 0 2 2 2 0 Response gene to complement 32 protein family Radical_SAM PF04055.21 AFZ81317.1 - 1.8e-21 77.2 0.0 3.5e-21 76.3 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily UPF0004 PF00919.20 AFZ81317.1 - 3.3e-19 68.7 0.0 1.1e-18 67.1 0.0 1.9 2 0 0 2 2 2 1 Uncharacterized protein family UPF0004 TRAM PF01938.20 AFZ81317.1 - 0.00016 21.6 0.0 0.00033 20.6 0.0 1.5 1 0 0 1 1 1 1 TRAM domain S1 PF00575.23 AFZ81318.1 - 1.7e-10 41.1 0.2 9e-10 38.8 0.0 2.3 3 0 0 3 3 3 1 S1 RNA binding domain DUF4074 PF13293.6 AFZ81318.1 - 0.015 15.6 0.1 0.029 14.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4074) LEDGF PF11467.8 AFZ81318.1 - 0.058 13.0 0.3 0.13 11.9 0.3 1.6 1 0 0 1 1 1 0 Lens epithelium-derived growth factor (LEDGF) Complex1_LYR_2 PF13233.6 AFZ81318.1 - 0.089 13.6 0.1 0.43 11.4 0.1 2.1 2 0 0 2 2 2 0 Complex1_LYR-like S1 PF00575.23 AFZ81319.1 - 0.086 13.2 0.1 0.25 11.7 0.1 1.8 1 0 0 1 1 1 0 S1 RNA binding domain CAF1 PF04857.20 AFZ81323.1 - 9.2e-21 74.3 0.7 3.6e-10 39.5 0.0 2.4 1 1 1 2 2 2 2 CAF1 family ribonuclease HTH_11 PF08279.12 AFZ81323.1 - 0.14 12.1 0.1 14 5.8 0.0 2.3 2 0 0 2 2 2 0 HTH domain DUF2009 PF09418.10 AFZ81325.1 - 9.5e-195 648.0 3.7 3.9e-127 425.1 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF2009) MIT_C PF16565.5 AFZ81325.1 - 0.065 13.2 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 Phospholipase D-like domain at C-terminus of MIT RE_Eco47II PF09553.10 AFZ81325.1 - 0.1 12.2 2.4 2.6 7.6 0.3 2.3 2 0 0 2 2 2 0 Eco47II restriction endonuclease Cyclin_N PF00134.23 AFZ81326.1 - 5.5e-07 29.4 0.7 1.2e-06 28.3 0.7 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF5595 PF18077.1 AFZ81326.1 - 0.073 13.2 0.2 0.26 11.4 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) RasGEF PF00617.19 AFZ81327.1 - 0.22 11.7 4.1 1.1 9.4 1.5 2.7 2 1 0 2 2 2 0 RasGEF domain Ras PF00071.22 AFZ81328.1 - 7e-42 142.8 0.2 1e-41 142.3 0.2 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AFZ81328.1 - 1.9e-29 102.3 0.2 7.7e-29 100.4 0.1 2.0 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AFZ81328.1 - 1.5e-13 50.6 0.1 1.3e-12 47.5 0.1 1.9 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 AFZ81328.1 - 2.7e-07 30.3 0.1 4.1e-07 29.7 0.1 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 AFZ81328.1 - 0.00016 21.7 0.1 0.00042 20.4 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AFZ81328.1 - 0.0011 18.9 1.0 0.94 9.4 0.2 2.3 2 0 0 2 2 2 2 RsgA GTPase ATP_bind_1 PF03029.17 AFZ81328.1 - 0.0012 18.7 0.1 0.028 14.2 0.0 2.1 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein Gtr1_RagA PF04670.12 AFZ81328.1 - 0.0031 16.9 0.2 0.014 14.8 0.2 2.1 1 1 1 2 2 2 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 AFZ81328.1 - 0.0049 16.3 0.2 0.11 11.9 0.0 2.4 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit DUF2341 PF10102.9 AFZ81328.1 - 0.31 11.7 2.0 1.7 9.3 0.5 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF2341) HAP2-GCS1 PF10699.9 AFZ81329.1 - 1.3e-15 57.1 0.1 3.7e-15 55.6 0.1 1.9 1 0 0 1 1 1 1 Male gamete fusion factor zf-HC5HC2H_2 PF13832.6 AFZ81330.1 - 8.1e-40 135.4 28.1 2.8e-19 69.3 3.3 6.1 6 0 0 6 6 6 3 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 AFZ81330.1 - 3.1e-15 56.2 23.6 4.5e-07 30.0 10.6 8.7 5 3 4 9 9 9 3 PHD-like zinc-binding domain PHD_2 PF13831.6 AFZ81330.1 - 1.6e-08 34.0 45.0 1.2e-05 24.7 5.1 6.6 5 0 0 5 5 5 3 PHD-finger PHD PF00628.29 AFZ81330.1 - 0.00038 20.3 11.2 0.00038 20.3 11.2 9.3 9 1 1 10 10 10 3 PHD-finger C1_1 PF00130.22 AFZ81330.1 - 0.0021 17.9 1.7 0.0021 17.9 1.7 7.4 7 0 0 7 7 7 4 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 AFZ81330.1 - 0.02 15.0 1.1 0.02 15.0 1.1 7.3 8 0 0 8 8 8 0 KIAA1045 RING finger zf-ribbon_3 PF13248.6 AFZ81330.1 - 0.21 11.0 4.7 0.67 9.4 1.4 3.7 2 0 0 2 2 2 0 zinc-ribbon domain tRNA-synt_1 PF00133.22 AFZ81331.1 - 2.8e-68 230.7 0.2 9.8e-45 152.9 0.0 2.3 1 1 1 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 AFZ81331.1 - 3.3e-11 42.6 0.1 2.3e-05 23.4 0.0 4.0 4 0 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 AFZ81331.1 - 0.0011 18.4 0.0 0.14 11.5 0.0 2.7 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1_2 PF13603.6 AFZ81331.1 - 0.0019 17.8 0.1 0.026 14.0 0.0 2.3 1 1 1 2 2 2 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1b PF00579.25 AFZ81331.1 - 0.0076 15.6 1.3 0.0085 15.4 0.1 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (W and Y) tRNA-synt_1d PF00750.19 AFZ81331.1 - 0.083 11.8 0.0 2.7 6.8 0.0 2.1 2 0 0 2 2 2 0 tRNA synthetases class I (R) PI3_PI4_kinase PF00454.27 AFZ81332.1 - 7.4e-48 163.5 0.0 1.1e-47 163.0 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase ubiquitin PF00240.23 AFZ81332.1 - 0.13 12.0 0.0 0.7 9.7 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin family Spec3 PF15795.5 AFZ81333.1 - 7.8e-05 23.1 15.8 0.0011 19.4 9.5 2.1 1 1 1 2 2 2 2 Ectodermal ciliogenesis protein DUF4282 PF14110.6 AFZ81333.1 - 0.31 11.8 6.4 0.49 11.2 6.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4282) Sybindin PF04099.12 AFZ81335.1 - 6.8e-36 123.3 0.2 7.5e-36 123.2 0.2 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 AFZ81335.1 - 0.0027 17.8 0.0 0.0034 17.5 0.0 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Cas_Cas1 PF01867.16 AFZ81335.1 - 0.17 11.0 0.0 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 CRISPR associated protein Cas1 PuR_N PF09182.10 AFZ81336.1 - 0.04 13.8 0.0 0.096 12.6 0.0 1.6 2 0 0 2 2 2 0 Bacterial purine repressor, N-terminal MTS PF05175.14 AFZ81338.1 - 1.6e-05 24.5 0.0 0.019 14.5 0.0 3.0 3 0 0 3 3 3 2 Methyltransferase small domain DUF938 PF06080.12 AFZ81338.1 - 0.0002 21.2 0.0 0.00045 20.0 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF938) SPOC PF07744.13 AFZ81339.1 - 3.5e-16 59.4 0.0 5.2e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 SPOC domain HABP4_PAI-RBP1 PF04774.15 AFZ81340.1 - 5.9e-10 40.0 2.9 5.9e-10 40.0 2.9 2.8 2 1 0 2 2 2 1 Hyaluronan / mRNA binding family Invasin_D3 PF09134.10 AFZ81340.1 - 0.013 15.7 0.5 0.033 14.5 0.5 1.6 1 0 0 1 1 1 0 Invasin, domain 3 DEAD PF00270.29 AFZ81341.1 - 2.3e-47 161.0 0.0 3.7e-47 160.4 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AFZ81341.1 - 3.4e-30 104.6 0.0 1.5e-29 102.5 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AFZ81341.1 - 0.00014 21.9 0.0 0.00028 21.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Peptidase_M17 PF00883.21 AFZ81343.1 - 1.2e-108 363.1 0.1 1.5e-108 362.8 0.1 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 AFZ81343.1 - 0.0047 16.8 0.0 0.019 14.8 0.0 2.0 2 0 0 2 2 2 1 Cytosol aminopeptidase family, N-terminal domain partial_CstF PF15861.5 AFZ81344.1 - 4.3e-23 80.9 0.3 1e-22 79.7 0.3 1.7 1 0 0 1 1 1 1 Partial cleavage stimulation factor domain CSTF2_hinge PF14327.6 AFZ81344.1 - 1.3e-15 57.6 0.6 3.6e-15 56.2 0.6 1.8 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 SGS PF05002.15 AFZ81345.1 - 1.8e-15 56.8 2.9 4.1e-15 55.6 2.9 1.7 1 1 0 1 1 1 1 SGS domain CS PF04969.16 AFZ81345.1 - 0.0074 17.3 2.8 0.031 15.3 2.6 2.1 1 1 1 2 2 2 1 CS domain CPW_WPC PF09717.10 AFZ81346.1 - 1.4e-16 61.2 7.3 2.6e-14 53.9 1.1 2.3 2 0 0 2 2 2 2 Plasmodium falciparum domain of unknown function (CPW_WPC) zf_PR_Knuckle PF18445.1 AFZ81346.1 - 1.9 8.4 7.8 26 4.7 4.4 2.3 2 0 0 2 2 2 0 PR zinc knuckle motif FH2 PF02181.23 AFZ81347.1 - 1.1e-64 218.9 6.7 1.1e-64 218.9 6.7 2.1 2 0 0 2 2 2 1 Formin Homology 2 Domain TPR_12 PF13424.6 AFZ81347.1 - 9.5e-09 35.4 0.8 0.00029 21.0 0.0 3.8 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 AFZ81347.1 - 0.00012 21.8 0.5 0.49 10.3 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat APG17 PF04108.12 AFZ81347.1 - 0.0094 15.1 0.4 0.0094 15.1 0.4 2.0 2 0 0 2 2 2 1 Autophagy protein Apg17 TPR_2 PF07719.17 AFZ81347.1 - 0.065 13.4 4.3 55 4.2 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 AFZ81347.1 - 0.089 12.7 8.0 0.5 10.3 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 AFZ81347.1 - 0.099 12.7 0.2 1.6 9.0 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 AFZ81347.1 - 1.5 9.2 6.7 3.7 8.0 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TH1 PF04858.13 AFZ81348.1 - 9.7e-13 47.6 8.0 1.3e-07 30.7 2.7 3.8 4 1 0 4 4 4 3 TH1 protein DUF1031 PF06275.11 AFZ81348.1 - 1.5 9.1 4.7 4 7.8 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1031) SlyX PF04102.12 AFZ81349.1 - 0.013 16.1 3.4 0.036 14.7 0.4 2.8 2 1 0 2 2 2 0 SlyX BTB_2 PF02214.22 AFZ81350.1 - 3.7e-15 56.0 0.2 1.3e-14 54.3 0.2 1.9 1 1 0 1 1 1 1 BTB/POZ domain Mito_carr PF00153.27 AFZ81351.1 - 4.5e-28 97.0 0.7 8.6e-16 57.6 0.1 2.7 2 1 1 3 3 3 2 Mitochondrial carrier protein Mito_carr PF00153.27 AFZ81352.1 - 4.9e-06 26.4 0.0 4.9e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial carrier protein Pkinase PF00069.25 AFZ81353.1 - 1.2e-71 241.1 0.2 1.6e-71 240.8 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ81353.1 - 1.1e-35 123.2 0.1 1.7e-35 122.6 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AFZ81353.1 - 2.1e-05 23.6 1.7 7e-05 21.9 1.7 1.7 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 AFZ81353.1 - 2.7e-05 23.6 0.0 0.00013 21.5 0.0 1.9 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 AFZ81353.1 - 0.0011 18.6 0.2 0.0017 18.0 0.2 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 AFZ81353.1 - 0.0046 16.3 0.2 0.0073 15.7 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3148 PF11347.8 AFZ81353.1 - 0.061 13.1 0.2 1.2 9.0 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3148) Memo PF01875.17 AFZ81354.1 - 2.9e-68 229.9 0.0 3.5e-68 229.7 0.0 1.1 1 0 0 1 1 1 1 Memo-like protein Seadorna_VP6 PF07407.11 AFZ81354.1 - 0.084 11.8 0.1 0.13 11.2 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP6 protein LETM1 PF07766.13 AFZ81355.1 - 2.9e-83 279.3 13.5 2.9e-83 279.3 13.5 2.0 2 1 1 3 3 3 1 LETM1-like protein HTH_26 PF13443.6 AFZ81355.1 - 0.03 14.7 0.1 0.17 12.4 0.0 2.3 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain SAP PF02037.27 AFZ81355.1 - 0.23 11.3 8.0 8.6 6.2 0.2 4.2 3 0 0 3 3 3 0 SAP domain LON_substr_bdg PF02190.16 AFZ81355.1 - 4.2 7.2 11.1 0.16 11.8 1.9 2.7 3 0 0 3 3 3 0 ATP-dependent protease La (LON) substrate-binding domain Synaptobrevin PF00957.21 AFZ81355.1 - 6.5 6.6 8.5 0.31 10.9 0.9 2.7 3 0 0 3 3 3 0 Synaptobrevin Cbl_N2 PF02761.14 AFZ81355.1 - 7 7.4 9.8 12 6.7 0.7 4.2 4 1 1 5 5 5 0 CBL proto-oncogene N-terminus, EF hand-like domain CRAL_TRIO PF00650.20 AFZ81356.1 - 1.1e-20 73.9 0.0 1.7e-20 73.4 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 AFZ81356.1 - 2.5e-05 24.3 2.3 8.7e-05 22.6 2.3 2.1 1 1 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 AFZ81356.1 - 0.0028 17.8 0.0 0.0049 17.0 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Het-C PF07217.11 AFZ81356.1 - 0.17 10.3 0.2 0.29 9.6 0.2 1.5 1 1 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Band_7 PF01145.25 AFZ81357.1 - 3.7e-06 27.1 0.2 5.2e-06 26.6 0.2 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family Helicase_C PF00271.31 AFZ81357.1 - 0.14 12.5 0.3 0.47 10.8 0.0 1.9 2 0 0 2 2 2 0 Helicase conserved C-terminal domain Maf1 PF09174.10 AFZ81358.1 - 2.6e-28 99.4 5.5 3.6e-28 98.9 5.5 1.2 1 0 0 1 1 1 1 Maf1 regulator PHD_2 PF13831.6 AFZ81359.1 - 0.088 12.4 0.3 0.7 9.5 0.0 2.5 2 0 0 2 2 2 0 PHD-finger RRM_1 PF00076.22 AFZ81360.1 - 1.2e-06 28.2 0.0 2e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Btz PF09405.10 AFZ81360.1 - 0.052 13.8 0.0 0.06 13.6 0.0 1.1 1 0 0 1 1 1 0 CASC3/Barentsz eIF4AIII binding Arf PF00025.21 AFZ81361.1 - 1.9e-59 200.0 0.0 2.2e-59 199.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 AFZ81361.1 - 6.6e-13 48.5 0.1 3.2e-09 36.4 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 AFZ81361.1 - 3.1e-10 40.3 0.0 6.7e-10 39.2 0.0 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 AFZ81361.1 - 3.4e-10 40.0 0.0 4.5e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 AFZ81361.1 - 2e-09 37.1 0.0 2.5e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 AFZ81361.1 - 5.2e-08 32.7 0.0 6.2e-08 32.4 0.0 1.3 1 1 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 AFZ81361.1 - 4.3e-06 26.3 0.0 5e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 AFZ81361.1 - 0.00038 20.1 0.0 0.0092 15.5 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 AFZ81361.1 - 0.002 18.4 0.1 0.037 14.3 0.1 2.1 1 1 0 1 1 1 1 AAA domain cobW PF02492.19 AFZ81361.1 - 0.011 15.3 0.1 1 8.9 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 AFZ81361.1 - 0.014 15.3 0.1 3.5 7.5 0.0 2.1 1 1 1 2 2 2 0 RsgA GTPase NACHT PF05729.12 AFZ81361.1 - 0.019 14.9 0.1 0.19 11.7 0.1 2.1 1 1 0 1 1 1 0 NACHT domain NOG1 PF06858.14 AFZ81361.1 - 0.067 13.0 0.1 0.17 11.7 0.1 1.7 1 1 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) PduV-EutP PF10662.9 AFZ81361.1 - 0.096 12.4 0.0 0.21 11.3 0.0 1.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 AFZ81361.1 - 0.14 12.6 0.0 0.21 12.1 0.0 1.4 1 1 0 1 1 1 0 ABC transporter FeoB_N PF02421.18 AFZ81361.1 - 0.16 11.5 0.1 0.45 10.0 0.1 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B CAS_CSE1 PF03378.15 AFZ81362.1 - 1.4e-45 155.6 7.0 4.3e-45 154.0 7.0 1.8 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus Cse1 PF08506.10 AFZ81362.1 - 3.1e-45 154.6 11.5 5.2e-45 153.9 11.5 1.4 1 0 0 1 1 1 1 Cse1 IBN_N PF03810.19 AFZ81362.1 - 0.059 13.3 0.0 3.7 7.5 0.0 3.0 2 0 0 2 2 2 0 Importin-beta N-terminal domain RRM_1 PF00076.22 AFZ81363.1 - 8.6e-46 153.6 0.0 2.1e-22 78.7 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AFZ81363.1 - 2e-08 34.2 0.3 9.1e-05 22.5 0.0 3.5 3 0 0 3 3 3 2 RNA recognition motif RRM_occluded PF16842.5 AFZ81363.1 - 1.8e-07 30.9 0.0 0.27 11.1 0.0 3.6 3 0 0 3 3 3 3 Occluded RNA-recognition motif RRM_3 PF08777.11 AFZ81363.1 - 0.0011 19.0 0.2 2.9 8.0 0.0 3.2 4 0 0 4 4 4 2 RNA binding motif Nup35_RRM_2 PF14605.6 AFZ81363.1 - 0.0023 17.9 0.1 0.036 14.1 0.0 2.5 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif DbpA PF03880.15 AFZ81363.1 - 0.012 15.6 0.0 7.6 6.6 0.0 3.4 3 0 0 3 3 3 0 DbpA RNA binding domain Tk-SP_N-pro PF18237.1 AFZ81363.1 - 0.02 14.9 0.0 0.045 13.8 0.0 1.5 1 0 0 1 1 1 0 Tk-SP N-propeptide domain DUF4651 PF15513.6 AFZ81363.1 - 0.059 13.2 0.0 18 5.3 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4651) zf-RING_5 PF14634.6 AFZ81364.1 - 5.8e-09 35.8 7.7 1.1e-08 34.8 7.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 AFZ81364.1 - 7.7e-08 32.2 4.8 4.1e-07 29.9 3.5 2.5 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 AFZ81364.1 - 3.2e-07 30.1 10.7 5.8e-06 26.1 10.8 2.2 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AFZ81364.1 - 6.1e-07 29.7 9.5 1.1e-06 28.9 8.4 2.1 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 AFZ81364.1 - 9.1e-07 28.7 4.8 1.9e-06 27.6 3.9 2.1 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 AFZ81364.1 - 9.1e-06 25.4 8.6 8.4e-05 22.3 5.3 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 AFZ81364.1 - 0.00079 19.2 11.8 0.0012 18.6 5.3 3.0 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 AFZ81364.1 - 0.0023 18.2 5.8 0.0054 17.0 5.0 2.1 1 1 1 2 2 2 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 AFZ81364.1 - 0.0027 17.4 7.6 0.35 10.7 2.5 3.4 2 1 0 2 2 2 2 RING-like zinc finger Rtf2 PF04641.12 AFZ81364.1 - 0.0037 16.7 1.6 0.0037 16.7 1.6 1.5 2 0 0 2 2 2 1 Rtf2 RING-finger DUF4121 PF13497.6 AFZ81364.1 - 0.031 13.5 0.0 0.048 12.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4121) zf-C3HC4_4 PF15227.6 AFZ81364.1 - 0.035 14.2 9.0 0.049 13.8 5.1 2.6 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 AFZ81364.1 - 0.096 12.5 8.1 0.59 10.0 8.4 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zinc-ribbons_6 PF07191.12 AFZ81364.1 - 0.11 12.5 6.8 0.25 11.4 6.8 1.6 1 1 0 1 1 1 0 zinc-ribbons SURF1 PF02104.15 AFZ81365.1 - 4.4e-30 105.2 0.0 7.1e-30 104.5 0.0 1.3 1 0 0 1 1 1 1 SURF1 family RabGAP-TBC PF00566.18 AFZ81366.1 - 0.0016 18.1 0.2 0.0057 16.3 0.2 2.0 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Hce2 PF14856.6 AFZ81367.1 - 0.0042 17.3 0.4 0.016 15.5 0.1 1.9 2 0 0 2 2 2 1 Pathogen effector; putative necrosis-inducing factor SLATT_fungal PF18142.1 AFZ81367.1 - 0.1 12.6 0.1 0.36 10.8 0.1 1.9 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain DUF445 PF04286.12 AFZ81367.1 - 0.1 12.4 0.6 7.9 6.2 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF445) CCDC84 PF14968.6 AFZ81368.1 - 0.0002 21.1 0.4 0.00024 20.9 0.4 1.1 1 0 0 1 1 1 1 Coiled coil protein 84 zf-C2H2_2 PF12756.7 AFZ81368.1 - 0.00064 20.0 1.5 0.00077 19.8 1.5 1.2 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 AFZ81368.1 - 0.0017 18.6 3.6 0.0038 17.5 3.6 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding Phage_Gp17 PF17549.2 AFZ81368.1 - 0.022 14.8 1.6 0.028 14.4 1.3 1.3 1 1 0 1 1 1 0 Gene Product 17 tRNA_m1G_MT PF01746.21 AFZ81369.1 - 5.8e-18 65.3 0.1 7.9e-18 64.9 0.1 1.2 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase EF-hand_7 PF13499.6 AFZ81370.1 - 1.1e-07 32.2 0.2 0.00078 19.9 0.1 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 AFZ81370.1 - 0.00011 21.8 0.3 0.18 11.8 0.0 4.0 4 0 0 4 4 4 1 EF-hand domain EF-hand_9 PF14658.6 AFZ81370.1 - 0.00053 20.3 0.1 0.014 15.7 0.0 2.6 2 1 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 AFZ81370.1 - 0.024 14.2 0.1 4.5 7.0 0.0 3.9 4 0 0 4 4 4 0 EF hand EF-hand_12 PF17901.1 AFZ81370.1 - 0.072 13.6 0.1 0.35 11.3 0.0 2.1 2 1 0 2 2 2 0 EF-hand fold domain zf-Tim10_DDP PF02953.15 AFZ81371.1 - 1.1e-10 41.0 1.8 1.3e-10 40.8 1.8 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger XPG_I PF00867.18 AFZ81372.1 - 2.9e-25 88.4 0.0 8.4e-25 87.0 0.0 1.9 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 AFZ81372.1 - 6e-18 65.2 0.0 1.4e-17 64.1 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 AFZ81372.1 - 0.0002 21.0 0.0 0.0005 19.6 0.0 1.6 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.20 AFZ81372.1 - 0.039 14.6 0.2 1.5 9.4 0.0 2.6 2 0 0 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold MNE1 PF13762.6 AFZ81372.1 - 0.25 11.3 6.4 0.052 13.5 1.9 2.1 2 0 0 2 2 2 0 Mitochondrial splicing apparatus component Kelch_3 PF13415.6 AFZ81373.1 - 1.6e-20 72.9 2.4 8.1e-07 29.2 0.0 6.3 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.6 AFZ81373.1 - 3.5e-19 68.5 4.6 3.7e-06 26.8 0.8 5.9 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.6 AFZ81373.1 - 5.6e-16 58.1 2.8 5.5e-07 29.4 0.1 5.9 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.6 AFZ81373.1 - 2.8e-11 43.3 1.5 0.00027 21.1 0.3 4.7 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 AFZ81373.1 - 2.8e-08 33.2 1.1 0.00017 21.1 0.1 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 AFZ81373.1 - 6e-08 32.4 4.8 0.00018 21.3 0.1 4.6 5 0 0 5 5 5 2 Kelch motif Mannosyl_trans PF05007.13 AFZ81376.1 - 2.3e-64 217.8 30.2 2.3e-64 217.8 30.2 1.6 2 0 0 2 2 2 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 AFZ81376.1 - 1.6e-09 37.3 40.7 2.4e-09 36.7 40.7 1.2 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U GT87 PF09594.10 AFZ81376.1 - 0.0009 19.0 0.1 0.0009 19.0 0.1 2.6 3 0 0 3 3 3 1 Glycosyltransferase family 87 U3snoRNP10 PF12397.8 AFZ81378.1 - 0.026 14.9 0.4 0.026 14.9 0.4 4.0 4 0 0 4 4 4 0 U3 small nucleolar RNA-associated protein 10 polyprenyl_synt PF00348.17 AFZ81378.1 - 0.053 12.6 0.3 0.12 11.4 0.3 1.6 1 0 0 1 1 1 0 Polyprenyl synthetase RHD3 PF05879.12 AFZ81382.1 - 4.7e-93 312.7 11.6 2.7e-91 306.9 11.6 2.3 1 1 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 AFZ81382.1 - 1.7e-07 30.8 0.1 3.2e-07 29.9 0.1 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 AFZ81382.1 - 0.0018 18.3 0.2 0.0043 17.1 0.2 1.7 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 AFZ81382.1 - 0.023 14.7 0.0 0.076 13.1 0.0 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase Rep_N PF08724.10 AFZ81382.1 - 0.04 13.7 0.1 0.42 10.3 0.0 2.5 2 0 0 2 2 2 0 Rep protein catalytic domain like Peptidase_C14 PF00656.22 AFZ81383.1 - 5.5e-32 111.7 0.0 1.3e-31 110.4 0.0 1.6 2 0 0 2 2 2 1 Caspase domain BNIP2 PF12496.8 AFZ81383.1 - 0.13 12.7 2.1 0.25 11.8 1.3 1.8 2 0 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 PEPcase_2 PF14010.6 AFZ81384.1 - 0.001 17.7 1.2 0.001 17.7 1.2 1.8 1 1 1 2 2 2 1 Phosphoenolpyruvate carboxylase TPR_MLP1_2 PF07926.12 AFZ81384.1 - 0.01 15.9 3.1 0.01 15.9 3.1 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Syntaxin_2 PF14523.6 AFZ81384.1 - 0.032 14.6 1.8 0.032 14.6 1.8 2.3 1 1 1 2 2 2 0 Syntaxin-like protein PRKG1_interact PF15898.5 AFZ81384.1 - 0.037 14.9 1.1 0.037 14.9 1.1 2.1 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain APG6_N PF17675.1 AFZ81384.1 - 0.039 14.5 7.8 0.32 11.5 7.8 2.0 1 1 0 1 1 1 0 Apg6 coiled-coil region Laminin_II PF06009.12 AFZ81384.1 - 0.05 13.6 2.9 0.12 12.4 2.9 1.6 1 0 0 1 1 1 0 Laminin Domain II Spectrin PF00435.21 AFZ81384.1 - 0.085 13.3 5.1 0.19 12.3 1.4 2.1 1 1 1 2 2 2 0 Spectrin repeat Cor1 PF04803.12 AFZ81384.1 - 0.09 13.0 7.8 0.62 10.3 3.0 2.3 1 1 1 2 2 2 0 Cor1/Xlr/Xmr conserved region UPF0242 PF06785.11 AFZ81384.1 - 0.38 10.8 9.7 0.58 10.2 9.7 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DMPK_coil PF08826.10 AFZ81384.1 - 0.43 10.7 3.5 1 9.5 0.1 2.8 1 1 1 2 2 2 0 DMPK coiled coil domain like DUF5617 PF18493.1 AFZ81384.1 - 0.56 10.3 4.4 16 5.6 4.4 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF5617) DUF1319 PF07028.11 AFZ81384.1 - 0.69 10.1 6.3 8.2 6.7 5.5 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) V-ATPase_G_2 PF16999.5 AFZ81384.1 - 0.83 10.1 3.8 0.89 10.0 1.1 2.0 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit TMPIT PF07851.13 AFZ81384.1 - 2.6 7.2 9.2 0.77 8.9 4.0 1.9 1 1 1 2 2 2 0 TMPIT-like protein NYD-SP28 PF14772.6 AFZ81384.1 - 6.8 6.8 15.0 18 5.5 3.0 3.0 1 1 1 2 2 2 0 Sperm tail Ribosomal_L44 PF00935.19 AFZ81386.1 - 4.7e-33 113.5 13.5 6.4e-33 113.1 13.5 1.2 1 0 0 1 1 1 1 Ribosomal protein L44 Ribosomal_S6 PF01250.17 AFZ81387.1 - 2.2e-11 43.9 0.0 2.7e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 ABA_GPCR PF12430.8 AFZ81388.1 - 1.3e-11 44.6 7.0 3.2e-11 43.3 7.0 1.7 1 0 0 1 1 1 1 Abscisic acid G-protein coupled receptor PhoR PF11808.8 AFZ81388.1 - 1 9.8 2.7 48 4.5 0.3 2.8 2 0 0 2 2 2 0 Phosphate regulon sensor protein PhoR DUF1218 PF06749.12 AFZ81388.1 - 1.8 9.1 0.0 1.8 9.1 0.0 3.1 3 1 1 4 4 4 0 Protein of unknown function (DUF1218) AAA_lid_7 PF17867.1 AFZ81389.1 - 0.072 13.3 0.1 14 5.9 0.0 2.8 2 0 0 2 2 2 0 Midasin AAA lid domain TPR_8 PF13181.6 AFZ81389.1 - 0.1 12.9 6.9 1.5 9.3 0.1 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat FliL PF03748.14 AFZ81389.1 - 0.13 12.9 1.1 3.5 8.3 0.2 2.7 2 0 0 2 2 2 0 Flagellar basal body-associated protein FliL Arm PF00514.23 AFZ81389.1 - 0.17 12.0 6.8 0.23 11.5 0.0 4.6 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat TPR_2 PF07719.17 AFZ81389.1 - 0.68 10.2 2.9 16 5.9 0.4 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 AFZ81389.1 - 5.1 7.1 8.0 12 6.0 0.1 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat OHA PF14418.6 AFZ81390.1 - 1.3e-18 66.6 0.0 3.6e-18 65.1 0.0 1.8 1 0 0 1 1 1 1 OST-HTH Associated domain WD40 PF00400.32 AFZ81391.1 - 1.2e-29 102.0 27.2 2.1e-07 31.5 0.4 11.4 12 1 0 12 12 12 7 WD domain, G-beta repeat Utp12 PF04003.12 AFZ81391.1 - 2.4e-14 53.5 0.1 5.1e-14 52.5 0.1 1.6 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 AFZ81391.1 - 2.9e-09 37.1 0.3 1 9.7 0.1 7.3 5 3 4 9 9 9 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AFZ81391.1 - 2.7e-05 24.1 0.9 0.61 9.9 0.0 5.2 5 1 1 6 6 6 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 AFZ81391.1 - 0.061 12.3 0.3 2.4 7.1 0.0 3.6 4 2 0 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Utp13 PF08625.11 AFZ81391.1 - 0.081 12.8 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Utp13 specific WD40 associated domain MSV199 PF10553.9 AFZ81394.1 - 1.1 9.5 4.5 2.3 8.4 0.1 2.7 3 0 0 3 3 3 0 MSV199 domain SprT-like PF10263.9 AFZ81395.1 - 1.3e-25 89.5 0.7 1e-24 86.6 0.3 2.1 2 0 0 2 2 2 1 SprT-like family DUF1241 PF06840.11 AFZ81395.1 - 0.038 13.6 0.0 0.07 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1241) Peptidase_M91 PF14891.6 AFZ81395.1 - 0.21 11.9 0.0 0.33 11.3 0.0 1.4 1 0 0 1 1 1 0 Effector protein EF1G PF00647.19 AFZ81396.1 - 2.6e-33 114.3 0.1 4.5e-33 113.5 0.1 1.4 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 AFZ81396.1 - 0.00092 19.4 0.1 0.0042 17.3 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 AFZ81396.1 - 0.0065 16.6 0.2 0.021 15.0 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Ribosomal_L6e PF01159.19 AFZ81397.1 - 4.9e-26 91.4 0.4 1e-25 90.4 0.4 1.5 1 1 0 1 1 1 1 Ribosomal protein L6e Peptidase_M41 PF01434.18 AFZ81398.1 - 4.3e-52 176.8 0.6 7.3e-52 176.0 0.6 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 AFZ81398.1 - 7.5e-41 139.7 0.0 3.3e-40 137.6 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AFZ81398.1 - 4.1e-08 32.9 0.1 1.1e-07 31.5 0.1 1.8 1 0 0 1 1 1 1 AAA+ lid domain TIP49 PF06068.13 AFZ81398.1 - 6.3e-05 22.3 0.7 0.0006 19.1 0.0 2.5 2 1 1 3 3 3 1 TIP49 P-loop domain RuvB_N PF05496.12 AFZ81398.1 - 0.0018 18.1 0.0 0.0078 16.0 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Zeta_toxin PF06414.12 AFZ81398.1 - 0.0018 17.6 0.2 0.0071 15.6 0.1 1.9 2 0 0 2 2 2 1 Zeta toxin AAA_16 PF13191.6 AFZ81398.1 - 0.0027 18.1 0.8 0.059 13.8 0.1 2.6 2 1 0 3 3 2 1 AAA ATPase domain AAA_28 PF13521.6 AFZ81398.1 - 0.0079 16.4 0.1 0.077 13.2 0.1 2.3 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 AFZ81398.1 - 0.0087 16.1 0.0 0.033 14.2 0.0 1.9 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 AFZ81398.1 - 0.02 14.6 0.0 3.2 7.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 AFZ81398.1 - 0.021 15.1 0.1 0.77 10.0 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_2 PF07724.14 AFZ81398.1 - 0.025 14.7 0.0 0.1 12.7 0.0 2.0 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 AFZ81398.1 - 0.028 14.4 0.4 0.17 11.8 0.1 2.5 2 1 0 2 2 1 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 AFZ81398.1 - 0.034 13.9 0.1 0.33 10.7 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein ATPase PF06745.13 AFZ81398.1 - 0.037 13.4 0.4 0.17 11.2 0.0 2.2 3 0 0 3 3 3 0 KaiC Mg_chelatase PF01078.21 AFZ81398.1 - 0.038 13.4 0.1 0.15 11.4 0.3 1.9 2 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 AFZ81398.1 - 0.052 13.7 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 AFZ81398.1 - 0.075 12.6 0.8 2.6 7.6 0.5 2.3 1 1 1 2 2 2 0 AAA domain Reprolysin_3 PF13582.6 AFZ81398.1 - 0.079 13.5 0.1 0.32 11.5 0.0 2.0 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like AAA_18 PF13238.6 AFZ81398.1 - 0.1 13.1 0.2 0.5 10.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF745 PF05335.13 AFZ81398.1 - 0.15 11.8 0.4 0.8 9.4 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF745) RRM_Rrp7 PF17799.1 AFZ81399.1 - 0.0091 15.8 3.9 0.15 11.9 0.1 3.7 4 0 0 4 4 4 1 Rrp7 RRM-like N-terminal domain Kri1_C PF12936.7 AFZ81400.1 - 9.2e-15 54.6 0.1 9.2e-15 54.6 0.1 3.3 4 0 0 4 4 4 1 KRI1-like family C-terminal Kri1 PF05178.12 AFZ81400.1 - 1.4e-07 32.0 2.2 1.4e-07 32.0 2.2 3.3 4 1 0 4 4 4 1 KRI1-like family zf-UBR PF02207.20 AFZ81400.1 - 0.19 11.9 6.3 0.35 11.1 6.3 1.4 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) ZZ PF00569.17 AFZ81400.1 - 0.22 11.3 9.6 0.53 10.1 9.6 1.6 1 0 0 1 1 1 0 Zinc finger, ZZ type PH PF00169.29 AFZ81402.1 - 0.047 14.2 0.0 0.29 11.7 0.0 2.3 2 0 0 2 2 2 0 PH domain AAA_23 PF13476.6 AFZ81403.1 - 6.2e-15 56.2 0.1 6.2e-15 56.2 0.1 5.8 2 2 1 3 3 3 1 AAA domain SMC_N PF02463.19 AFZ81403.1 - 3.8e-12 46.1 26.7 2.6e-11 43.4 26.7 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 AFZ81403.1 - 0.0012 18.5 0.0 0.0026 17.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain DEAD PF00270.29 AFZ81404.1 - 1.4e-18 67.3 0.0 3.4e-18 66.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AFZ81404.1 - 8.5e-18 64.7 0.1 6.6e-16 58.6 0.0 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RQC PF09382.10 AFZ81404.1 - 3e-11 43.1 0.0 1.3e-10 41.1 0.0 2.1 1 0 0 1 1 1 1 RQC domain RecQ_Zn_bind PF16124.5 AFZ81404.1 - 1.4e-10 41.7 8.2 2.4e-10 41.0 3.9 3.5 3 0 0 3 3 3 1 RecQ zinc-binding ResIII PF04851.15 AFZ81404.1 - 2e-08 34.4 0.3 2.4e-07 30.9 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Dfp1_Him1_M PF08630.10 AFZ81404.1 - 0.093 12.9 1.1 10 6.3 0.3 2.6 2 0 0 2 2 2 0 Dfp1/Him1, central region Rib_recp_KP_reg PF05104.12 AFZ81404.1 - 0.53 11.3 7.3 7.2 7.6 3.1 2.3 2 0 0 2 2 2 0 Ribosome receptor lysine/proline rich region Tmemb_40 PF10160.9 AFZ81405.1 - 0.029 13.8 0.9 0.051 13.0 0.9 1.3 1 0 0 1 1 1 0 Predicted membrane protein CpxA_peri PF16527.5 AFZ81406.1 - 0.024 15.0 1.4 0.024 15.0 1.4 1.9 1 1 1 2 2 2 0 Two-component sensor protein CpxA, periplasmic domain Thymidylat_synt PF00303.19 AFZ81407.1 - 4.6e-112 373.5 0.0 1.3e-111 372.1 0.0 1.6 2 0 0 2 2 2 1 Thymidylate synthase DHFR_1 PF00186.19 AFZ81407.1 - 3.8e-25 88.4 0.0 2.5e-24 85.8 0.0 2.1 1 1 0 1 1 1 1 Dihydrofolate reductase Pkinase PF00069.25 AFZ81408.1 - 9.8e-28 97.2 1.2 1.4e-27 96.8 0.1 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ81408.1 - 2.7e-18 66.2 0.0 5.2e-18 65.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Myb_DNA-binding PF00249.31 AFZ81409.1 - 2.4e-07 30.8 0.1 0.02 15.1 0.0 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AFZ81409.1 - 1 9.6 8.8 0.46 10.8 0.3 3.3 3 0 0 3 3 3 0 Myb-like DNA-binding domain Hat1_N PF10394.9 AFZ81410.1 - 1e-08 35.6 4.1 6e-05 23.3 2.4 2.5 2 0 0 2 2 2 2 Histone acetyl transferase HAT1 N-terminus MOZ_SAS PF01853.18 AFZ81410.1 - 0.0038 16.9 1.4 0.0089 15.7 0.1 2.3 2 1 0 2 2 2 1 MOZ/SAS family DUF463 PF04317.12 AFZ81410.1 - 0.11 11.4 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 YcjX-like family, DUF463 MCM PF00493.23 AFZ81411.1 - 2.2e-49 167.6 3.8 1.7e-47 161.4 3.5 3.0 2 1 0 2 2 2 1 MCM P-loop domain MCM_lid PF17855.1 AFZ81411.1 - 1.5e-16 60.6 0.0 3.5e-16 59.4 0.0 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 AFZ81411.1 - 3e-08 33.3 0.2 1.2e-05 24.9 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI MCM_OB PF17207.3 AFZ81411.1 - 1.3e-05 25.0 1.1 2.7e-05 24.0 0.5 1.9 2 0 0 2 2 2 1 MCM OB domain Sigma54_activat PF00158.26 AFZ81411.1 - 0.00087 19.0 0.1 0.62 9.7 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA PF00004.29 AFZ81411.1 - 0.01 16.2 0.0 0.032 14.6 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 AFZ81411.1 - 0.023 14.7 0.0 0.16 11.9 0.0 2.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) GH3 PF03321.13 AFZ81411.1 - 0.03 13.2 0.1 0.11 11.4 0.0 1.9 1 1 1 2 2 2 0 GH3 auxin-responsive promoter AAA_7 PF12775.7 AFZ81411.1 - 0.071 12.6 0.6 0.29 10.6 0.2 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_16 PF13191.6 AFZ81411.1 - 0.11 12.9 0.2 0.22 11.9 0.2 1.4 1 0 0 1 1 1 0 AAA ATPase domain Ribosomal_L37 PF08561.10 AFZ81413.1 - 6.2e-05 23.5 7.2 0.00076 20.0 0.8 2.4 1 1 1 2 2 2 2 Mitochondrial ribosomal protein L37 GTP_EFTU PF00009.27 AFZ81414.1 - 1.2e-44 152.2 0.0 1.5e-44 151.9 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 AFZ81414.1 - 3.2e-23 82.2 0.0 1.2e-22 80.3 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 AFZ81414.1 - 0.00017 21.9 0.1 0.00066 20.0 0.0 2.1 3 0 0 3 3 3 1 Elongation factor Tu domain 2 PAM2 PF07145.15 AFZ81414.1 - 0.0012 18.4 2.7 0.0012 18.4 2.7 2.0 2 0 0 2 2 2 1 Ataxin-2 C-terminal region MMR_HSR1 PF01926.23 AFZ81414.1 - 0.0015 18.6 0.1 0.0082 16.2 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase LRR_4 PF12799.7 AFZ81415.1 - 5.4e-07 29.8 23.8 0.024 15.1 0.0 7.0 2 2 7 9 9 9 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 AFZ81415.1 - 0.00031 20.5 13.3 1.3 9.3 0.3 6.7 7 0 0 7 7 7 2 Leucine Rich repeat LRR_1 PF00560.33 AFZ81415.1 - 0.0044 17.4 20.6 3.7 8.5 1.3 7.6 8 1 1 9 9 9 2 Leucine Rich Repeat LRR_8 PF13855.6 AFZ81415.1 - 0.011 15.5 14.6 0.26 11.1 0.1 5.6 4 1 2 6 6 6 0 Leucine rich repeat Mnd1 PF03962.15 AFZ81415.1 - 0.063 13.6 0.4 0.24 11.7 0.4 2.0 1 0 0 1 1 1 0 Mnd1 HTH domain ATHILA PF03078.15 AFZ81415.1 - 0.074 11.8 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 ATHILA ORF-1 family Pkinase PF00069.25 AFZ81416.1 - 3.3e-75 252.9 0.7 5.7e-75 252.1 0.7 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ81416.1 - 3.9e-39 134.5 0.1 9.3e-39 133.3 0.1 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 AFZ81416.1 - 3.4e-13 50.0 0.2 1e-12 48.5 0.2 1.9 1 0 0 1 1 1 1 PH domain EF-hand_1 PF00036.32 AFZ81416.1 - 5.6e-11 41.2 6.5 0.0055 16.2 0.4 4.0 3 0 0 3 3 3 3 EF hand Kinase-like PF14531.6 AFZ81416.1 - 8.5e-11 41.7 0.1 2.3e-09 37.0 0.0 2.2 2 0 0 2 2 2 1 Kinase-like EF-hand_6 PF13405.6 AFZ81416.1 - 1e-10 40.6 5.3 0.004 17.0 0.1 4.2 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 AFZ81416.1 - 1e-08 35.5 7.2 0.021 15.2 0.1 4.0 3 0 0 3 3 3 3 EF-hand domain pair Kdo PF06293.14 AFZ81416.1 - 1.6e-05 24.4 0.6 3.2e-05 23.4 0.6 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family EF-hand_5 PF13202.6 AFZ81416.1 - 1.7e-05 24.1 1.0 0.038 13.5 0.8 3.5 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 AFZ81416.1 - 2.6e-05 23.9 4.7 0.45 10.4 0.0 3.9 4 0 0 4 4 4 2 EF-hand domain pair RIO1 PF01163.22 AFZ81416.1 - 6.7e-05 22.6 0.5 0.00019 21.1 0.5 1.7 1 0 0 1 1 1 1 RIO1 family FTA2 PF13095.6 AFZ81416.1 - 0.0013 18.4 0.5 0.12 11.9 0.0 2.4 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 AFZ81416.1 - 0.0054 15.6 4.1 0.0069 15.2 0.0 2.6 3 0 0 3 3 3 1 Fungal protein kinase Rhodanese_C PF12368.8 AFZ81416.1 - 1 9.8 6.0 15 6.0 6.3 2.6 1 1 0 1 1 1 0 Rhodanase C-terminal DZR PF12773.7 AFZ81416.1 - 4.3 7.4 5.8 21 5.3 6.0 2.1 1 1 1 2 2 2 0 Double zinc ribbon zinc_ribbon_4 PF13717.6 AFZ81416.1 - 9.4 6.2 7.3 8.4 6.4 0.9 2.6 1 1 1 2 2 2 0 zinc-ribbon domain zf-UBR PF02207.20 AFZ81417.1 - 4.9e-14 52.3 15.4 4.9e-14 52.3 15.4 3.7 4 0 0 4 4 4 1 Putative zinc finger in N-recognin (UBR box) DUF2726 PF10881.8 AFZ81417.1 - 0.098 12.5 0.1 0.23 11.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2726) NUMOD3 PF07460.11 AFZ81417.1 - 0.15 12.3 0.1 7.3 6.9 0.0 2.7 2 0 0 2 2 2 0 NUMOD3 motif (2 copies) Surp PF01805.20 AFZ81418.1 - 1.4e-37 127.4 1.1 2.2e-18 66.0 0.1 2.4 2 0 0 2 2 2 2 Surp module PRP21_like_P PF12230.8 AFZ81418.1 - 2e-36 125.9 11.2 4.3e-35 121.6 11.2 2.3 1 1 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein MscS_TM PF12794.7 AFZ81418.1 - 0.089 11.6 1.0 0.13 11.1 1.0 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 zf-WRNIP1_ubi PF18279.1 AFZ81418.1 - 0.21 12.3 0.6 0.43 11.3 0.6 1.5 1 0 0 1 1 1 0 Werner helicase-interacting protein 1 ubiquitin-binding domain RrnaAD PF00398.20 AFZ81420.1 - 5.5e-57 192.8 0.0 7.5e-57 192.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 AFZ81420.1 - 8.2e-10 39.3 0.0 1.7e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AFZ81420.1 - 4.4e-09 36.3 0.0 8.9e-09 35.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 AFZ81420.1 - 1.3e-07 31.3 0.0 9.6e-06 25.2 0.0 2.4 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_11 PF08241.12 AFZ81420.1 - 9.5e-07 29.4 0.0 3e-06 27.8 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AFZ81420.1 - 6.7e-06 25.6 0.0 1.1e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 AFZ81420.1 - 0.00011 22.9 0.0 0.00022 21.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 AFZ81420.1 - 0.00024 20.9 0.0 0.00039 20.2 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 AFZ81420.1 - 0.0015 18.4 0.0 0.003 17.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.12 AFZ81420.1 - 0.01 14.9 0.0 0.016 14.3 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase DUF43 PF01861.16 AFZ81420.1 - 0.035 13.3 0.0 0.061 12.5 0.0 1.3 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain NodS PF05401.11 AFZ81420.1 - 0.075 12.6 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) PrmA PF06325.13 AFZ81420.1 - 0.087 12.2 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) HEAT PF02985.22 AFZ81421.1 - 7.3e-21 72.5 13.1 0.0099 16.1 0.1 10.9 13 0 0 13 13 13 6 HEAT repeat HEAT_2 PF13646.6 AFZ81421.1 - 2.1e-12 47.2 0.0 0.48 10.9 0.0 6.7 5 3 2 7 7 7 4 HEAT repeats Cnd1 PF12717.7 AFZ81421.1 - 6.4e-08 32.8 9.2 0.016 15.3 0.1 4.6 4 1 0 4 4 4 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 AFZ81421.1 - 1.1e-06 29.1 6.1 1.7e-05 25.3 0.7 4.5 3 1 1 4 4 4 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 AFZ81421.1 - 2.4e-05 24.7 1.0 4.6 7.9 0.0 6.1 6 1 1 7 7 7 1 HEAT-like repeat UME PF08064.13 AFZ81421.1 - 0.0071 16.2 4.4 9.8 6.2 0.1 4.4 4 0 0 4 4 4 2 UME (NUC010) domain CLASP_N PF12348.8 AFZ81421.1 - 0.0072 15.9 2.2 0.73 9.3 0.0 3.3 3 1 0 3 3 3 1 CLASP N terminal DUF4042 PF13251.6 AFZ81421.1 - 0.037 13.7 1.6 27 4.4 0.0 4.8 6 1 1 7 7 7 0 Domain of unknown function (DUF4042) TAF6_C PF07571.13 AFZ81421.1 - 0.058 13.7 0.1 2.5 8.5 0.0 3.5 5 1 0 5 5 5 0 TAF6 C-terminal HEAT repeat domain ALAD PF00490.21 AFZ81422.1 - 1.3e-81 274.3 0.3 2.3e-81 273.4 0.3 1.4 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase Peptidase_M16_C PF05193.21 AFZ81422.1 - 1.6e-21 77.1 0.0 7.1e-11 42.5 0.0 2.9 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 AFZ81422.1 - 8.2e-17 61.6 1.1 6e-16 58.8 0.3 2.6 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) zf-B_box PF00643.24 AFZ81423.1 - 2e-12 47.1 18.9 1.8e-07 31.2 5.0 2.5 2 0 0 2 2 2 2 B-box zinc finger DUF1031 PF06275.11 AFZ81423.1 - 5.2 7.4 6.3 1.5 9.1 2.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1031) RNA_pol_L_2 PF13656.6 AFZ81424.1 - 6.9e-29 99.4 0.0 8.3e-29 99.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 AFZ81424.1 - 7.3e-09 34.9 0.0 1.5e-08 34.0 0.0 1.5 2 0 0 2 2 2 1 RNA polymerase Rpb3/Rpb11 dimerisation domain tRNA-synt_2 PF00152.20 AFZ81425.1 - 9.6e-66 222.0 0.0 1.3e-65 221.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 AFZ81425.1 - 1.5e-08 34.4 0.0 2.7e-05 23.8 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA_anti-codon PF01336.25 AFZ81425.1 - 2.1e-05 24.4 0.3 8e-05 22.6 0.3 1.9 1 1 0 1 1 1 1 OB-fold nucleic acid binding domain FAINT PF04385.15 AFZ81426.1 - 1.4e-06 28.3 0.7 6e-06 26.2 0.3 2.0 1 1 1 2 2 2 1 Domain of unknown function, DUF529 Prefoldin_2 PF01920.20 AFZ81427.1 - 1.9e-16 59.9 0.8 2.3e-16 59.7 0.8 1.1 1 0 0 1 1 1 1 Prefoldin subunit XhlA PF10779.9 AFZ81427.1 - 0.0041 17.3 3.2 0.19 12.0 0.1 2.1 2 0 0 2 2 2 2 Haemolysin XhlA Nsp1_C PF05064.13 AFZ81427.1 - 0.016 15.0 0.8 0.035 13.9 0.1 1.7 2 0 0 2 2 2 0 Nsp1-like C-terminal region Prefoldin PF02996.17 AFZ81427.1 - 0.052 13.5 3.4 1.8 8.5 3.4 2.0 1 1 0 1 1 1 0 Prefoldin subunit DHR10 PF18595.1 AFZ81427.1 - 0.071 13.2 4.0 0.7 10.0 0.7 2.1 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain UPF0242 PF06785.11 AFZ81427.1 - 0.085 13.0 1.0 0.74 9.9 0.2 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus APG6_N PF17675.1 AFZ81427.1 - 0.23 12.0 6.6 2.4 8.7 1.8 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region AKNA PF12443.8 AFZ81428.1 - 0.15 12.7 7.3 0.074 13.7 1.0 3.0 3 0 0 3 3 3 0 AT-hook-containing transcription factor Torus PF16131.5 AFZ81431.1 - 5.9e-33 113.8 0.4 5.9e-33 113.8 0.4 1.8 2 0 0 2 2 2 1 Torus domain RRM_1 PF00076.22 AFZ81431.1 - 3.4e-07 30.0 0.1 1.4e-06 28.0 0.1 2.1 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_4 PF18044.1 AFZ81431.1 - 0.0018 18.0 4.6 0.0047 16.7 4.6 1.7 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 AFZ81431.1 - 0.57 10.3 6.5 1.4 9.1 6.5 1.7 1 0 0 1 1 1 0 Zinc finger domain FAINT PF04385.15 AFZ81432.1 - 1.7e-09 37.6 8.2 0.057 13.5 0.0 5.8 5 0 0 5 5 5 5 Domain of unknown function, DUF529 TIM PF00121.18 AFZ81433.1 - 5.5e-60 202.7 0.2 6.8e-60 202.4 0.2 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase CLP1_P PF16575.5 AFZ81434.1 - 9.1e-23 81.0 0.0 1.4e-22 80.4 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Carb_bind PF10645.9 AFZ81434.1 - 0.038 14.2 0.1 0.087 13.1 0.1 1.5 1 0 0 1 1 1 0 Carbohydrate binding RNA_helicase PF00910.22 AFZ81434.1 - 0.087 13.2 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 AFZ81434.1 - 0.12 12.9 0.0 0.19 12.3 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 AFZ81434.1 - 0.13 12.4 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain Rad21_Rec8_N PF04825.13 AFZ81436.1 - 5.6e-08 32.9 0.7 1.7e-07 31.4 0.1 2.1 2 0 0 2 2 2 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 AFZ81436.1 - 0.00077 18.7 0.0 0.0016 17.7 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein Motile_Sperm PF00635.26 AFZ81437.1 - 5.3e-25 87.4 0.1 8.2e-25 86.8 0.1 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain ASH PF15780.5 AFZ81437.1 - 0.0047 17.1 0.1 0.01 16.0 0.1 1.6 1 1 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin RNA_pol_Rpb6 PF01192.22 AFZ81438.1 - 3e-17 62.3 0.0 4.9e-17 61.6 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb6 FAINT PF04385.15 AFZ81440.1 - 0.0048 16.9 0.1 0.012 15.7 0.1 1.8 1 1 0 1 1 1 1 Domain of unknown function, DUF529 T4-Gluco-transf PF09198.10 AFZ81440.1 - 0.13 11.9 0.1 2.2 8.0 0.0 2.3 2 0 0 2 2 2 0 Bacteriophage T4 beta-glucosyltransferase LNS2 PF08235.13 AFZ81441.1 - 7.3e-94 313.5 0.0 1e-93 313.0 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 AFZ81441.1 - 1.6e-25 89.0 0.0 4.9e-25 87.4 0.0 1.8 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.5 AFZ81441.1 - 1.8e-20 73.0 0.0 8e-20 70.9 0.0 2.1 3 0 0 3 3 3 1 Lipin/Ned1/Smp2 multi-domain protein middle domain Ank_2 PF12796.7 AFZ81442.1 - 7.8e-25 87.3 3.4 5.3e-10 39.7 0.1 3.3 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) DHHC PF01529.20 AFZ81442.1 - 1.4e-22 80.3 14.4 1.4e-22 80.3 14.4 2.5 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ank_4 PF13637.6 AFZ81442.1 - 3.5e-21 75.3 3.8 2.4e-08 34.3 0.1 4.6 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 AFZ81442.1 - 8.1e-15 53.5 3.9 0.0045 17.4 0.0 5.2 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 AFZ81442.1 - 1.6e-13 50.6 1.2 0.00011 22.5 0.0 4.4 1 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 AFZ81442.1 - 1e-12 47.8 4.9 5.5e-05 23.4 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat GCP_N_terminal PF17681.1 AFZ81443.1 - 8.8e-29 101.1 1.5 1.4e-28 100.4 1.5 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 AFZ81443.1 - 1.2e-24 87.3 13.1 1.9e-23 83.4 13.1 2.4 1 1 0 1 1 1 1 Gamma tubulin complex component C-terminal DUF4162 PF13732.6 AFZ81443.1 - 0.095 13.4 0.1 31 5.4 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4162) 2-oxoacid_dh PF00198.23 AFZ81444.1 - 9.8e-66 221.5 0.1 1.4e-65 221.0 0.1 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 AFZ81444.1 - 4e-18 65.0 1.5 8.7e-18 63.9 1.5 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 AFZ81444.1 - 3.8e-10 39.9 0.1 1.3e-09 38.2 0.1 2.0 1 0 0 1 1 1 1 e3 binding domain HlyD_D23 PF16576.5 AFZ81444.1 - 0.00013 21.3 0.1 0.00019 20.7 0.1 1.4 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 AFZ81444.1 - 0.0026 17.5 0.1 0.0083 15.9 0.1 1.8 1 0 0 1 1 1 1 Biotin-lipoyl like HlyD_3 PF13437.6 AFZ81444.1 - 0.063 14.0 0.0 0.17 12.6 0.0 1.7 1 0 0 1 1 1 0 HlyD family secretion protein GCV_H PF01597.19 AFZ81444.1 - 0.067 13.1 0.1 0.15 11.9 0.1 1.6 1 0 0 1 1 1 0 Glycine cleavage H-protein PYNP_C PF07831.13 AFZ81444.1 - 0.075 12.7 0.5 3.2 7.5 0.0 2.6 1 1 1 2 2 2 0 Pyrimidine nucleoside phosphorylase C-terminal domain IMCp PF12314.8 AFZ81445.1 - 1e-28 99.4 98.0 8.4e-18 64.5 39.7 4.0 2 2 1 3 3 3 3 Inner membrane complex protein DUF5472 PF17566.2 AFZ81446.1 - 0.029 14.3 0.5 3.5 7.7 0.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5472) Phage_holin_Dp1 PF16938.5 AFZ81446.1 - 0.029 14.6 1.7 1.7 8.9 0.0 2.7 2 0 0 2 2 2 0 Putative phage holin Dp-1 BRCT_3 PF18428.1 AFZ81446.1 - 0.041 14.0 0.0 0.092 12.8 0.0 1.5 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain TLD PF07534.16 AFZ81447.1 - 2.5e-17 63.4 0.0 6.5e-17 62.1 0.0 1.8 1 0 0 1 1 1 1 TLD RabGAP-TBC PF00566.18 AFZ81447.1 - 2.8e-14 53.3 3.6 5e-14 52.5 2.8 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Rad51 PF08423.11 AFZ81448.1 - 3.5e-18 65.8 0.0 4.4e-18 65.5 0.0 1.0 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 AFZ81448.1 - 0.0057 16.3 0.1 0.0079 15.8 0.1 1.1 1 0 0 1 1 1 1 AAA domain Rad51 PF08423.11 AFZ81449.1 - 1.7e-12 47.2 0.0 1.9e-12 47.0 0.0 1.0 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 AFZ81449.1 - 3.4e-10 39.8 0.0 4.3e-10 39.5 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 AFZ81449.1 - 6.6e-08 32.2 0.1 8.3e-08 31.9 0.1 1.2 1 0 0 1 1 1 1 KaiC AAA_25 PF13481.6 AFZ81449.1 - 0.00086 18.9 0.0 0.001 18.7 0.0 1.1 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 AFZ81449.1 - 0.0011 18.3 0.0 0.0014 18.1 0.0 1.1 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain PAXNEB PF05625.11 AFZ81449.1 - 0.0029 16.8 0.0 0.0029 16.8 0.0 1.1 1 0 0 1 1 1 1 PAXNEB protein RNA_helicase PF00910.22 AFZ81449.1 - 0.0058 17.0 0.1 0.049 14.0 0.0 2.0 2 0 0 2 2 2 1 RNA helicase ATPase_2 PF01637.18 AFZ81449.1 - 0.0064 16.4 0.1 0.0073 16.2 0.1 1.2 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 AFZ81449.1 - 0.015 15.0 0.0 0.023 14.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 AFZ81449.1 - 0.025 15.1 0.1 0.034 14.7 0.1 1.2 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 AFZ81449.1 - 0.056 13.7 0.0 0.1 12.9 0.0 1.4 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 AFZ81449.1 - 0.071 13.5 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 AFZ81449.1 - 0.11 11.6 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_33 PF13671.6 AFZ81449.1 - 0.11 12.6 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 AFZ81449.1 - 0.13 12.1 0.0 0.15 12.0 0.0 1.1 1 0 0 1 1 1 0 NACHT domain TsaE PF02367.17 AFZ81449.1 - 0.14 12.1 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 AFZ81449.1 - 0.15 12.4 0.0 0.17 12.3 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain DUF2075 PF09848.9 AFZ81449.1 - 0.16 11.2 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_18 PF13238.6 AFZ81449.1 - 0.16 12.5 0.0 0.23 12.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 AFZ81449.1 - 0.22 10.7 0.0 0.26 10.5 0.0 1.1 1 0 0 1 1 1 0 NB-ARC domain AAA_11 PF13086.6 AFZ81449.1 - 0.25 11.1 0.0 0.27 11.0 0.0 1.1 1 0 0 1 1 1 0 AAA domain Exonuc_VII_S PF02609.16 AFZ81450.1 - 0.18 11.9 1.0 10 6.3 0.1 2.4 2 0 0 2 2 2 0 Exonuclease VII small subunit DIX PF00778.17 AFZ81451.1 - 6.2e-13 48.4 0.0 8.5e-13 47.9 0.0 1.2 1 0 0 1 1 1 1 DIX domain DUF966 PF06136.13 AFZ81451.1 - 0.24 11.1 0.0 0.31 10.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Fumble PF03630.14 AFZ81453.1 - 5.9e-53 180.2 0.2 1.5e-52 178.8 0.2 1.7 1 1 0 1 1 1 1 Fumble DUF3336 PF11815.8 AFZ81453.1 - 0.14 11.9 0.1 0.24 11.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3336) EF-hand_7 PF13499.6 AFZ81455.1 - 0.005 17.3 0.0 0.012 16.1 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair Caps_synth_CapC PF14102.6 AFZ81455.1 - 0.015 15.7 0.4 0.015 15.7 0.4 3.2 5 0 0 5 5 5 0 Capsule biosynthesis CapC Exo_endo_phos_2 PF14529.6 AFZ81455.1 - 0.044 13.6 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase NADH_dh_m_C1 PF15088.6 AFZ81455.1 - 0.23 11.1 2.8 0.19 11.4 0.7 1.9 2 0 0 2 2 2 0 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial DUF3139 PF11337.8 AFZ81455.1 - 0.26 11.9 0.1 0.26 11.9 0.1 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF3139) zf-CCCH PF00642.24 AFZ81456.1 - 9.9e-08 31.7 20.4 2.6e-06 27.2 2.5 4.2 3 1 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 AFZ81456.1 - 1.9e-05 24.5 5.9 1.9e-05 24.5 5.9 4.4 5 0 0 5 5 5 1 Zinc finger domain zf-CCCH_4 PF18044.1 AFZ81456.1 - 0.00011 21.9 4.1 0.00011 21.9 4.1 4.0 3 2 0 3 3 3 1 CCCH-type zinc finger Torus PF16131.5 AFZ81456.1 - 0.0099 16.6 4.9 0.0099 16.6 4.9 2.8 1 1 1 2 2 2 1 Torus domain zf-CCCH_2 PF14608.6 AFZ81456.1 - 0.11 13.0 17.3 1.8 9.2 1.8 3.8 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger zf-C2H2_jaz PF12171.8 AFZ81457.1 - 1.4e-05 25.2 4.5 1.4e-05 25.2 4.5 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-U1 PF06220.12 AFZ81457.1 - 0.00012 21.8 0.7 0.00026 20.7 0.7 1.6 1 0 0 1 1 1 1 U1 zinc finger zf-C2H2_4 PF13894.6 AFZ81457.1 - 0.037 14.9 0.9 0.12 13.3 0.9 2.0 1 1 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 AFZ81457.1 - 0.04 14.2 0.5 0.04 14.2 0.5 1.6 1 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Helo_like_N PF17111.5 AFZ81457.1 - 0.044 13.2 0.1 0.051 12.9 0.1 1.2 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins PRK PF00485.18 AFZ81457.1 - 0.051 13.3 0.2 0.057 13.2 0.2 1.3 1 1 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family zf-met PF12874.7 AFZ81457.1 - 0.11 13.0 1.1 0.11 13.0 1.1 2.3 2 0 0 2 2 2 0 Zinc-finger of C2H2 type LtuB PF17455.2 AFZ81457.1 - 0.14 12.7 0.6 0.14 12.7 0.6 1.6 2 0 0 2 2 2 0 Late transcription unit B zf-H2C2_2 PF13465.6 AFZ81457.1 - 0.2 12.1 0.3 0.2 12.1 0.3 2.7 3 0 0 3 3 3 0 Zinc-finger double domain Wbp11 PF09429.10 AFZ81457.1 - 0.79 10.2 5.7 0.25 11.8 2.2 1.7 2 0 0 2 2 2 0 WW domain binding protein 11 Pkinase PF00069.25 AFZ81458.1 - 9.9e-39 133.3 0.2 2.9e-38 131.8 0.2 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ81458.1 - 2.2e-18 66.5 0.1 4.3e-18 65.5 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Cyclin_N PF00134.23 AFZ81458.1 - 2.6e-07 30.4 0.3 7.3e-07 29.0 0.3 1.8 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF5537 PF17690.1 AFZ81458.1 - 0.11 12.2 0.4 2.3 7.9 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5537) JAB PF01398.21 AFZ81459.1 - 1.4e-16 60.5 0.5 2.3e-16 59.9 0.5 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 AFZ81459.1 - 1.4e-06 28.7 0.0 1.9e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function BRCT PF00533.26 AFZ81460.1 - 0.012 16.0 0.0 0.24 11.8 0.0 2.7 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain Sec-ASP3 PF15432.6 AFZ81460.1 - 0.029 14.5 0.0 0.17 12.0 0.0 2.2 2 0 0 2 2 2 0 Accessory Sec secretory system ASP3 PIGA PF08288.12 AFZ81461.1 - 0.11 13.1 0.0 0.25 11.9 0.0 1.6 1 0 0 1 1 1 0 PIGA (GPI anchor biosynthesis) ATP-synt_ab PF00006.25 AFZ81462.1 - 1.9e-64 217.2 0.0 2.6e-64 216.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 AFZ81462.1 - 2.6e-12 47.1 1.7 4.3e-12 46.4 1.7 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.10 AFZ81462.1 - 0.006 16.7 0.4 0.011 15.9 0.4 1.4 1 0 0 1 1 1 1 HAS barrel domain PI3K_P85_iSH2 PF16454.5 AFZ81464.1 - 0.0096 15.5 43.7 0.64 9.6 0.5 5.2 2 2 2 4 4 4 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF3573 PF12097.8 AFZ81464.1 - 1.8 7.3 8.5 0.54 9.0 3.0 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF3573) IFT57 PF10498.9 AFZ81464.1 - 2.6 6.9 55.8 0.018 14.1 11.7 4.6 3 1 1 4 4 4 0 Intra-flagellar transport protein 57 Mto2_bdg PF12808.7 AFZ81464.1 - 6.7 7.1 13.5 0.28 11.5 1.0 4.8 4 0 0 4 4 4 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Lectin_N PF03954.14 AFZ81464.1 - 9.3 6.0 31.0 0.57 9.9 9.6 4.5 3 3 1 4 4 4 0 Hepatic lectin, N-terminal domain PCI PF01399.27 AFZ81465.1 - 1.2e-18 67.6 0.0 4.3e-18 65.8 0.0 2.0 1 0 0 1 1 1 1 PCI domain Rpn3_C PF08375.11 AFZ81465.1 - 2.3e-18 66.4 0.0 6e-18 65.0 0.0 1.7 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal PPR_2 PF13041.6 AFZ81465.1 - 0.049 13.8 0.7 0.13 12.4 0.1 2.1 2 0 0 2 2 2 0 PPR repeat family TPR_2 PF07719.17 AFZ81465.1 - 0.067 13.3 10.2 0.29 11.3 0.3 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat SAM_Ste50p PF09235.10 AFZ81465.1 - 0.14 12.4 0.0 0.55 10.5 0.0 2.0 1 0 0 1 1 1 0 Ste50p, sterile alpha motif Corona_NSP4_C PF16348.5 AFZ81465.1 - 2.7 8.8 6.7 0.95 10.3 2.7 2.3 1 1 1 2 2 2 0 Coronavirus nonstructural protein 4 C-terminus DUF3972 PF13118.6 AFZ81466.1 - 0.017 15.5 1.6 0.017 15.5 1.6 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3972) DUF2605 PF10792.9 AFZ81466.1 - 0.06 13.3 0.0 0.23 11.4 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2605) DUF948 PF06103.11 AFZ81466.1 - 0.5 10.7 3.0 2.7 8.3 0.7 2.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) TMF_DNA_bd PF12329.8 AFZ81466.1 - 0.6 10.1 15.2 0.32 11.0 6.2 3.6 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding Atg14 PF10186.9 AFZ81466.1 - 0.72 8.9 16.3 0.069 12.2 11.7 1.7 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 BST2 PF16716.5 AFZ81466.1 - 7.7 7.2 10.8 3.7 8.2 1.5 3.7 3 0 0 3 3 3 0 Bone marrow stromal antigen 2 FAINT PF04385.15 AFZ81467.1 - 3.9e-08 33.2 6.1 0.0038 17.3 0.1 4.0 4 0 0 4 4 4 3 Domain of unknown function, DUF529 vATP-synt_AC39 PF01992.16 AFZ81468.1 - 1.5e-89 300.8 3.0 1.7e-89 300.7 3.0 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Ints3 PF10189.9 AFZ81468.1 - 0.096 11.9 0.4 7.8 5.7 0.1 2.3 2 0 0 2 2 2 0 Integrator complex subunit 3 PH PF00169.29 AFZ81469.1 - 0.003 18.0 0.7 0.019 15.5 0.3 2.8 2 1 0 2 2 2 1 PH domain YL1 PF05764.13 AFZ81470.1 - 3e-32 112.7 18.7 3e-32 112.7 18.7 1.9 2 0 0 2 2 2 1 YL1 nuclear protein YL1_C PF08265.11 AFZ81470.1 - 1.8e-10 40.4 0.7 4.5e-10 39.1 0.3 1.9 2 0 0 2 2 2 1 YL1 nuclear protein C-terminal domain TF_AP-2 PF03299.14 AFZ81470.1 - 0.0094 15.9 3.5 0.02 14.9 3.5 1.5 1 0 0 1 1 1 1 Transcription factor AP-2 DivIC PF04977.15 AFZ81472.1 - 1.7e-05 24.5 9.4 0.0038 17.0 3.9 3.6 3 0 0 3 3 3 2 Septum formation initiator Cep57_MT_bd PF06657.13 AFZ81472.1 - 0.00011 22.6 0.0 0.00011 22.6 0.0 3.0 3 0 0 3 3 3 1 Centrosome microtubule-binding domain of Cep57 WD40_alt PF14077.6 AFZ81472.1 - 0.0013 18.5 0.4 0.045 13.6 0.0 2.7 2 0 0 2 2 2 1 Alternative WD40 repeat motif Cep57_CLD_2 PF14197.6 AFZ81472.1 - 0.0045 17.1 20.0 0.12 12.5 0.2 4.6 3 1 0 4 4 4 2 Centrosome localisation domain of PPC89 DUF724 PF05266.14 AFZ81472.1 - 0.0051 16.7 6.5 0.0051 16.7 6.5 3.3 2 1 1 3 3 3 1 Protein of unknown function (DUF724) bZIP_1 PF00170.21 AFZ81472.1 - 0.0078 16.3 22.6 0.015 15.4 0.3 4.8 3 2 2 5 5 5 2 bZIP transcription factor CALCOCO1 PF07888.11 AFZ81472.1 - 0.0088 15.0 17.6 0.011 14.6 11.9 2.2 2 0 0 2 2 2 1 Calcium binding and coiled-coil domain (CALCOCO1) like Prefoldin PF02996.17 AFZ81472.1 - 0.051 13.5 11.5 4.7 7.2 0.0 4.7 4 1 0 4 4 4 0 Prefoldin subunit PDE8 PF08629.10 AFZ81472.1 - 0.071 13.1 0.1 0.19 11.7 0.1 1.7 1 0 0 1 1 1 0 PDE8 phosphodiesterase Pox_A_type_inc PF04508.12 AFZ81472.1 - 0.1 12.5 3.2 4 7.5 0.1 3.7 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat KASH_CCD PF14662.6 AFZ81472.1 - 0.15 11.8 23.4 0.79 9.5 12.9 3.3 3 1 0 3 3 2 0 Coiled-coil region of CCDC155 or KASH DUF4763 PF15960.5 AFZ81472.1 - 0.36 10.1 14.4 0.1 11.9 9.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) YabA PF06156.13 AFZ81472.1 - 0.49 11.1 20.1 2.2 9.0 3.5 3.9 3 1 1 4 4 3 0 Initiation control protein YabA ZapB PF06005.12 AFZ81472.1 - 0.55 10.7 21.4 6 7.4 0.0 4.2 4 0 0 4 4 3 0 Cell division protein ZapB bZIP_2 PF07716.15 AFZ81472.1 - 0.7 10.0 17.1 3 8.0 0.0 4.6 3 1 1 4 4 4 0 Basic region leucine zipper Lebercilin PF15619.6 AFZ81472.1 - 0.73 9.5 21.5 0.19 11.3 11.3 3.3 2 1 2 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease GIT_CC PF16559.5 AFZ81472.1 - 1 9.3 16.4 32 4.5 7.1 4.5 4 0 0 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF3450 PF11932.8 AFZ81472.1 - 1.1 8.6 13.8 4 6.7 7.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) ADIP PF11559.8 AFZ81472.1 - 1.2 9.2 21.7 0.078 13.1 11.7 3.0 3 1 1 4 4 3 0 Afadin- and alpha -actinin-Binding TSC22 PF01166.18 AFZ81472.1 - 2.4 8.5 16.4 6.2 7.2 0.1 4.7 4 1 0 4 4 4 0 TSC-22/dip/bun family TPR_MLP1_2 PF07926.12 AFZ81472.1 - 2.9 8.0 18.7 1.9 8.5 7.0 3.6 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein HAP1_N PF04849.13 AFZ81472.1 - 3.5 6.8 21.5 5.8 6.0 0.3 2.6 2 1 0 2 2 2 0 HAP1 N-terminal conserved region DUF2205 PF10224.9 AFZ81472.1 - 5.6 7.0 15.3 6.4 6.9 6.2 3.6 3 1 0 3 3 3 0 Short coiled-coil protein CBF PF03914.17 AFZ81473.1 - 3.4e-07 30.4 1.5 0.0066 16.5 0.1 2.8 1 1 1 2 2 2 2 CBF/Mak21 family NOC3p PF07540.11 AFZ81473.1 - 5.9e-05 23.4 0.0 0.00017 22.0 0.0 1.8 1 0 0 1 1 1 1 Nucleolar complex-associated protein UPF0113_N PF17833.1 AFZ81474.1 - 3.7e-30 104.3 0.2 6.3e-30 103.6 0.2 1.4 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 AFZ81474.1 - 4.7e-20 71.6 0.0 1.1e-19 70.4 0.0 1.6 2 0 0 2 2 2 1 UPF0113 PUA domain AP2 PF00847.20 AFZ81476.1 - 9e-14 51.5 0.1 2.3e-13 50.2 0.1 1.7 1 0 0 1 1 1 1 AP2 domain s48_45 PF07422.13 AFZ81477.1 - 0.0073 16.9 2.6 0.46 11.1 0.4 3.4 3 1 0 3 3 3 2 Sexual stage antigen s48/45 domain FAINT PF04385.15 AFZ81479.1 - 3e-18 65.6 2.1 8.6e-09 35.3 0.2 3.5 3 0 0 3 3 3 3 Domain of unknown function, DUF529 DUF4596 PF15363.6 AFZ81479.1 - 0.0028 17.9 13.7 98 3.3 0.1 7.7 7 0 0 7 7 7 0 Domain of unknown function (DUF4596) PC_rep PF01851.22 AFZ81480.1 - 1e-28 98.3 9.8 2.9e-07 30.6 0.2 7.7 7 0 0 7 7 7 6 Proteasome/cyclosome repeat RPN2_C PF18004.1 AFZ81480.1 - 6.6e-26 91.1 0.1 1.6e-12 47.7 0.1 2.2 2 0 0 2 2 2 2 26S proteasome regulatory subunit RPN2 C-terminal domain HEAT_2 PF13646.6 AFZ81480.1 - 1.7e-13 50.8 0.0 8.2e-08 32.5 0.1 5.3 4 2 2 6 6 6 2 HEAT repeats HEAT PF02985.22 AFZ81480.1 - 0.01 16.0 0.4 3.5 8.1 0.1 4.4 4 0 0 4 4 4 0 HEAT repeat HEAT_EZ PF13513.6 AFZ81480.1 - 0.82 10.2 3.4 11 6.7 0.0 4.2 5 1 1 6 6 6 0 HEAT-like repeat Metallophos PF00149.28 AFZ81481.1 - 4.8e-32 112.1 0.1 1.9e-31 110.2 0.1 2.0 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Kelch_5 PF13854.6 AFZ81481.1 - 4.4e-26 90.4 2.0 6.6e-05 22.8 0.0 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 AFZ81481.1 - 6.9e-22 77.2 12.2 0.0004 20.3 0.0 7.1 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 AFZ81481.1 - 1.2e-21 76.4 12.1 2.1e-05 24.7 0.1 7.2 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_2 PF07646.15 AFZ81481.1 - 6.1e-18 64.0 2.0 0.00079 19.3 0.0 6.4 5 1 1 6 6 6 4 Kelch motif Kelch_6 PF13964.6 AFZ81481.1 - 1.6e-16 59.9 2.2 0.01 16.1 0.0 6.1 4 1 1 5 5 5 5 Kelch motif Kelch_1 PF01344.25 AFZ81481.1 - 4.7e-15 54.9 4.3 0.00012 21.6 0.0 6.5 6 1 0 6 6 6 3 Kelch motif STPPase_N PF16891.5 AFZ81481.1 - 0.085 13.3 0.1 0.35 11.3 0.0 2.1 2 0 0 2 2 2 0 Serine-threonine protein phosphatase N-terminal domain Ribosomal_S3_C PF00189.20 AFZ81482.1 - 5.5e-25 87.7 1.4 1.9e-24 86.0 1.9 1.6 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 AFZ81482.1 - 6.7e-10 38.7 0.1 1.2e-09 37.9 0.1 1.4 1 0 0 1 1 1 1 KH domain UN_NPL4 PF11543.8 AFZ81482.1 - 0.019 15.4 0.0 0.046 14.2 0.0 1.6 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Coilin_N PF15862.5 AFZ81482.1 - 0.025 14.4 0.0 0.042 13.7 0.0 1.3 1 0 0 1 1 1 0 Coilin N-terminus MARVEL PF01284.23 AFZ81483.1 - 0.14 12.2 0.0 0.21 11.6 0.0 1.2 1 0 0 1 1 1 0 Membrane-associating domain Wzy_C PF04932.15 AFZ81483.1 - 0.3 10.7 2.9 1.2 8.8 2.4 1.9 2 1 0 2 2 2 0 O-Antigen ligase BK_channel_a PF03493.18 AFZ81484.1 - 7.6e-16 58.1 0.3 4.6e-15 55.6 0.1 2.5 2 1 0 2 2 2 1 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.16 AFZ81484.1 - 1.1e-08 34.9 8.6 1.1e-08 34.9 8.6 3.6 3 1 1 4 4 4 1 Ion channel CRPA PF05745.11 AFZ81485.1 - 0.016 15.2 0.5 0.019 15.0 0.5 1.2 1 0 0 1 1 1 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) DUF4282 PF14110.6 AFZ81485.1 - 0.067 13.9 4.6 0.087 13.6 4.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4282) SLATT_4 PF18186.1 AFZ81485.1 - 0.069 12.8 0.7 0.075 12.7 0.7 1.1 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 4 Phage_holin_5_2 PF16079.5 AFZ81485.1 - 0.084 13.2 4.3 0.085 13.2 2.9 1.6 1 1 1 2 2 2 0 Phage holin family Hol44, in holin superfamily V DUF5392 PF17370.2 AFZ81485.1 - 0.1 12.7 0.1 0.12 12.5 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5392) SafA PF17073.5 AFZ81485.1 - 0.33 10.9 3.4 0.32 11.0 2.4 1.4 1 1 0 1 1 1 0 Two-component-system connector protein Lactamase_B_2 PF12706.7 AFZ81486.1 - 4.1e-19 68.9 0.1 6.6e-19 68.2 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 AFZ81486.1 - 4.2e-05 23.6 1.7 0.00031 20.8 0.2 2.6 2 1 0 3 3 3 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.6 AFZ81486.1 - 0.058 13.1 0.0 0.18 11.5 0.0 2.0 1 1 0 1 1 1 0 tRNase Z endonuclease Lactamase_B_4 PF13691.6 AFZ81487.1 - 1.8e-05 24.4 0.1 2.8e-05 23.7 0.1 1.4 1 0 0 1 1 1 1 tRNase Z endonuclease DUF676 PF05057.14 AFZ81489.1 - 6.8e-26 91.1 0.2 1.2e-25 90.3 0.2 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 AFZ81489.1 - 1e-06 28.6 0.5 5.1e-06 26.4 0.1 2.1 1 1 1 2 2 2 1 PGAP1-like protein Palm_thioest PF02089.15 AFZ81489.1 - 3.7e-05 23.7 0.4 0.00024 21.0 0.0 2.1 2 0 0 2 2 2 1 Palmitoyl protein thioesterase LCAT PF02450.15 AFZ81489.1 - 0.00067 18.9 0.1 0.0011 18.2 0.1 1.4 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF900 PF05990.12 AFZ81489.1 - 0.05 13.1 0.6 0.78 9.2 0.0 2.5 2 1 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) FAINT PF04385.15 AFZ81492.1 - 6.5e-08 32.5 0.1 2.4e-06 27.5 0.0 3.1 2 1 1 3 3 3 1 Domain of unknown function, DUF529 Reovirus_L2 PF06016.11 AFZ81493.1 - 0.0073 13.6 0.1 0.01 13.1 0.1 1.1 1 0 0 1 1 1 1 Reovirus core-spike protein lambda-2 (L2) Spectrin PF00435.21 AFZ81493.1 - 0.1 13.1 4.5 9.3 6.8 0.3 3.1 2 1 0 2 2 2 0 Spectrin repeat BLOC1_2 PF10046.9 AFZ81493.1 - 0.14 12.5 3.2 0.69 10.2 0.6 3.6 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FAM76 PF16046.5 AFZ81493.1 - 0.53 9.6 4.3 1.2 8.5 4.3 1.5 1 0 0 1 1 1 0 FAM76 protein CCDC-167 PF15188.6 AFZ81493.1 - 0.54 10.6 8.4 3.5 8.0 1.5 3.0 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 167 DUF1664 PF07889.12 AFZ81493.1 - 0.98 9.5 6.3 0.12 12.5 0.4 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) RPW8 PF05659.11 AFZ81493.1 - 1.5 8.5 6.7 13 5.4 1.1 3.2 2 1 1 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 NPV_P10 PF05531.12 AFZ81493.1 - 9.5 6.8 12.0 3.7 8.1 0.5 5.5 4 2 1 5 5 5 0 Nucleopolyhedrovirus P10 protein FadR_C PF07840.12 AFZ81494.1 - 0.074 13.0 0.1 0.12 12.3 0.1 1.2 1 0 0 1 1 1 0 FadR C-terminal domain Enkurin PF13864.6 AFZ81494.1 - 0.16 12.4 0.2 1.7 9.1 0.1 2.1 2 0 0 2 2 2 0 Calmodulin-binding PFU PF09070.11 AFZ81496.1 - 0.00019 21.6 0.5 0.00031 21.0 0.5 1.2 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) Membrane_bind PF14564.6 AFZ81496.1 - 0.019 15.4 0.8 0.033 14.6 0.8 1.3 1 0 0 1 1 1 0 Membrane binding Interfer-bind PF09294.10 AFZ81496.1 - 0.024 14.9 0.3 0.061 13.7 0.1 1.8 1 1 0 1 1 1 0 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.21 AFZ81496.1 - 0.092 13.1 0.2 0.31 11.4 0.0 2.0 2 0 0 2 2 2 0 Fibronectin type III domain TQ PF18202.1 AFZ81496.1 - 0.75 10.3 5.1 0.81 10.2 1.7 2.5 1 1 2 3 3 3 0 T-Q ester bond containing domain DUF2293 PF10056.9 AFZ81497.1 - 0.066 13.5 0.0 0.078 13.2 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2293) PP2C PF00481.21 AFZ81498.1 - 5.8e-31 108.1 0.0 6.8e-31 107.8 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 AFZ81498.1 - 0.026 14.5 0.0 0.048 13.6 0.0 1.4 1 0 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 AFZ81498.1 - 0.062 12.9 0.0 0.099 12.3 0.0 1.4 1 1 0 1 1 1 0 Protein phosphatase 2C Pet127 PF08634.10 AFZ81498.1 - 0.094 12.1 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial protein Pet127 SMC_N PF02463.19 AFZ81499.1 - 8e-66 221.6 0.0 1.2e-33 116.4 0.0 2.7 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 AFZ81499.1 - 4e-15 56.1 0.0 1.9e-14 54.0 0.0 2.3 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 AFZ81499.1 - 4e-12 46.6 3.7 2.2e-06 27.7 0.3 3.1 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 AFZ81499.1 - 1.1e-09 39.1 1.0 1.1e-09 39.1 1.0 7.1 2 2 2 4 4 4 1 AAA domain AAA_15 PF13175.6 AFZ81499.1 - 1.2e-06 28.5 56.5 7e-05 22.7 20.7 4.4 2 2 1 3 3 3 2 AAA ATPase domain Atg14 PF10186.9 AFZ81499.1 - 0.0027 16.9 15.7 0.0027 16.9 15.7 5.6 2 2 3 5 5 5 1 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_29 PF13555.6 AFZ81499.1 - 0.0084 15.8 0.3 0.036 13.8 0.0 2.1 2 0 0 2 2 2 1 P-loop containing region of AAA domain HTH_3 PF01381.22 AFZ81499.1 - 0.029 14.4 1.1 0.2 11.7 0.2 2.7 2 0 0 2 2 2 0 Helix-turn-helix Chromo_2 PF18704.1 AFZ81499.1 - 5.3 7.4 7.3 0.68 10.2 0.8 2.8 2 0 0 2 2 2 0 Chromatin organization modifier domain 2 adh_short_C2 PF13561.6 AFZ81499.1 - 5.5 6.5 5.5 2 7.9 0.1 2.9 3 0 0 3 3 3 0 Enoyl-(Acyl carrier protein) reductase Hydrolase_4 PF12146.8 AFZ81500.1 - 9.8e-23 80.6 0.0 2.3e-21 76.2 0.0 2.8 2 1 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 AFZ81500.1 - 9.4e-07 28.8 4.4 0.11 12.6 0.0 4.8 5 0 0 5 5 5 3 Domain of unknown function, DUF529 Abhydrolase_1 PF00561.20 AFZ81500.1 - 0.0033 17.1 0.8 0.019 14.6 0.7 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Histone PF00125.24 AFZ81503.1 - 6.6e-15 55.6 0.1 8.4e-15 55.3 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 AFZ81503.1 - 4.2e-05 23.8 0.3 8.6e-05 22.8 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 AFZ81503.1 - 0.011 16.2 0.0 0.017 15.6 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Myb_DNA-binding PF00249.31 AFZ81505.1 - 3.4e-15 55.9 1.2 1.1e-07 31.9 0.1 3.7 3 0 0 3 3 3 2 Myb-like DNA-binding domain DnaJ PF00226.31 AFZ81505.1 - 4.4e-12 45.9 0.2 3.9e-10 39.7 0.1 3.6 2 1 0 2 2 2 1 DnaJ domain Myb_DNA-bind_6 PF13921.6 AFZ81505.1 - 2.8e-09 37.1 0.6 0.0041 17.3 0.0 3.8 3 0 0 3 3 3 3 Myb-like DNA-binding domain tRNA-synt_2e PF02091.15 AFZ81506.1 - 0.082 12.1 0.1 0.18 11.0 0.0 1.6 2 0 0 2 2 2 0 Glycyl-tRNA synthetase alpha subunit RRM_1 PF00076.22 AFZ81508.1 - 1.3e-57 191.5 5.4 9.3e-17 60.6 0.1 6.9 6 1 0 6 6 6 6 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 AFZ81508.1 - 5.9e-05 22.7 1.3 0.00059 19.4 0.3 2.4 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AFZ81508.1 - 0.00078 19.2 0.2 0.31 10.9 0.0 3.7 3 0 0 3 3 3 1 Occluded RNA-recognition motif Smg4_UPF3 PF03467.15 AFZ81508.1 - 0.0008 19.5 2.5 0.089 12.8 0.0 4.1 4 1 0 4 4 4 1 Smg-4/UPF3 family V-set_2 PF15910.5 AFZ81508.1 - 0.051 13.7 0.4 0.26 11.4 0.2 2.3 2 0 0 2 2 2 0 ICOS V-set domain DUF4523 PF15023.6 AFZ81508.1 - 0.066 13.0 0.1 0.16 11.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) PHM7_cyt PF14703.6 AFZ81508.1 - 0.76 10.0 5.1 8.5 6.6 1.0 4.1 3 1 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter Peptidase_C97 PF05903.14 AFZ81510.1 - 3.1e-29 101.7 0.1 4.1e-29 101.4 0.1 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain AAA_14 PF13173.6 AFZ81510.1 - 0.085 12.9 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Symplekin_C PF12295.8 AFZ81511.1 - 6.6e-26 91.5 1.3 4.1e-25 89.0 0.0 2.9 3 0 0 3 3 3 1 Symplekin tight junction protein C terminal NOT2_3_5 PF04153.18 AFZ81512.1 - 1e-16 61.2 3.7 1.7e-16 60.5 3.7 1.3 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family PCI PF01399.27 AFZ81513.1 - 9e-12 45.4 0.5 9e-12 45.4 0.5 2.3 2 1 0 2 2 2 1 PCI domain Ta0938 PF11494.8 AFZ81514.1 - 0.055 13.7 0.2 3.3 8.1 0.1 2.7 2 0 0 2 2 2 0 Ta0938 Dynamin_N PF00350.23 AFZ81514.1 - 0.059 13.4 0.3 0.18 11.9 0.3 1.8 1 0 0 1 1 1 0 Dynamin family CENP-T_C PF15511.6 AFZ81515.1 - 5e-09 36.2 0.1 6e-09 36.0 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 AFZ81515.1 - 0.00024 21.4 0.1 0.00032 21.0 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein TAF PF02969.17 AFZ81515.1 - 0.00047 20.3 0.0 0.00064 19.8 0.0 1.3 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 AFZ81515.1 - 0.00073 19.8 0.0 0.0011 19.2 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 AFZ81515.1 - 0.0038 17.6 0.1 0.0042 17.4 0.1 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 AFZ81515.1 - 0.043 13.9 0.0 0.049 13.7 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 AFZ81515.1 - 0.043 13.8 0.0 0.06 13.4 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated TAFII28 PF04719.14 AFZ81515.1 - 0.074 13.2 0.1 0.088 12.9 0.1 1.2 1 0 0 1 1 1 0 hTAFII28-like protein conserved region TIM PF00121.18 AFZ81516.1 - 1.6e-48 165.2 0.0 2.2e-48 164.7 0.0 1.2 1 0 0 1 1 1 1 Triosephosphate isomerase EF-hand_6 PF13405.6 AFZ81517.1 - 3.7e-05 23.3 0.1 0.00069 19.3 0.0 3.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 AFZ81517.1 - 4.1e-05 24.0 2.2 0.00031 21.1 0.1 3.3 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.6 AFZ81517.1 - 0.0002 21.2 0.1 0.0013 18.5 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 AFZ81517.1 - 0.00058 19.2 0.1 0.0036 16.7 0.0 2.5 2 0 0 2 2 2 1 EF hand RAP PF08373.10 AFZ81517.1 - 0.021 14.9 1.2 0.059 13.5 0.0 2.4 3 0 0 3 3 3 0 RAP domain EF-hand_9 PF14658.6 AFZ81517.1 - 0.096 13.0 0.1 0.73 10.2 0.0 2.6 3 0 0 3 3 3 0 EF-hand domain ANAPC4_WD40 PF12894.7 AFZ81518.1 - 7.3e-09 35.8 0.0 0.046 14.0 0.0 5.3 3 1 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AFZ81518.1 - 9.2e-09 35.8 3.5 0.0048 17.7 0.3 4.7 5 0 0 5 5 5 3 WD domain, G-beta repeat Ge1_WD40 PF16529.5 AFZ81518.1 - 0.084 11.8 3.2 0.91 8.4 1.3 3.2 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF1682 PF07946.14 AFZ81519.1 - 3e-40 138.4 2.4 4.6e-40 137.8 2.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) DUF3369 PF11849.8 AFZ81519.1 - 0.0064 16.7 0.1 0.012 15.9 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3369) HCNGP PF07818.13 AFZ81520.1 - 9.4e-16 58.3 0.3 1.7e-15 57.4 0.3 1.6 1 1 1 2 2 2 1 HCNGP-like protein KH_1 PF00013.29 AFZ81521.1 - 2.2e-10 40.2 0.2 6.9e-05 22.6 0.1 2.5 2 0 0 2 2 2 2 KH domain Ses_B PF17046.5 AFZ81521.1 - 0.044 13.8 0.3 6 6.9 0.2 2.5 2 0 0 2 2 2 0 SesB domain on fungal death-pathway protein DUF4968 PF16338.5 AFZ81521.1 - 0.098 13.0 0.6 0.3 11.4 0.6 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4968) DUF5496 PF17600.2 AFZ81522.1 - 0.23 11.5 0.9 1.2 9.2 0.1 2.2 2 1 0 2 2 2 0 Family of unknown function (DUF5496) WD40 PF00400.32 AFZ81523.1 - 2.5e-36 123.0 33.0 3.3e-06 27.7 4.4 7.6 8 0 0 8 8 8 7 WD domain, G-beta repeat Nup160 PF11715.8 AFZ81523.1 - 3.1e-05 22.8 2.4 0.35 9.4 0.1 3.5 1 1 2 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 AFZ81523.1 - 0.00014 21.3 0.1 0.54 9.5 0.0 2.5 3 0 0 3 3 3 2 WD40-like domain ANAPC4_WD40 PF12894.7 AFZ81523.1 - 0.0014 18.8 1.2 3.8 7.9 0.1 4.5 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Slp PF03843.13 AFZ81523.1 - 0.0058 16.0 0.0 2.6 7.4 0.0 2.5 2 0 0 2 2 2 2 Outer membrane lipoprotein Slp family FAT PF02259.23 AFZ81524.1 - 9.2e-15 54.7 0.4 2.7e-14 53.1 0.1 2.0 2 0 0 2 2 2 1 FAT domain FlhC PF05280.11 AFZ81524.1 - 6.1 6.5 5.8 0.91 9.2 0.6 2.3 3 0 0 3 3 3 0 Flagellar transcriptional activator (FlhC) Peptidase_C2 PF00648.21 AFZ81525.1 - 1.5e-34 119.4 0.0 2e-33 115.7 0.0 2.3 1 1 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 AFZ81525.1 - 2.5e-11 44.0 0.3 5.2e-10 39.7 0.0 2.7 2 0 0 2 2 2 1 Calpain large subunit, domain III TIP49 PF06068.13 AFZ81526.1 - 6.7e-150 499.2 0.8 8.2e-150 498.9 0.8 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 AFZ81526.1 - 1.5e-19 69.8 0.0 4.5e-19 68.3 0.0 1.9 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 AFZ81526.1 - 1.2e-09 38.7 1.5 4.9e-07 30.2 0.1 2.7 3 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 AFZ81526.1 - 1.7e-07 31.1 0.5 6.1e-06 26.1 0.1 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AFZ81526.1 - 1.1e-05 25.8 0.0 2.2e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AFZ81526.1 - 8e-05 22.9 0.0 0.059 13.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 AFZ81526.1 - 0.00014 22.3 0.2 0.00043 20.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 AFZ81526.1 - 0.00069 19.1 0.1 0.0065 15.9 0.1 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 AFZ81526.1 - 0.00071 20.1 0.1 0.0014 19.2 0.1 1.5 1 0 0 1 1 1 1 ABC transporter AAA_5 PF07728.14 AFZ81526.1 - 0.00081 19.4 0.0 0.012 15.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) DnaB_C PF03796.15 AFZ81526.1 - 0.0022 17.4 0.1 0.0034 16.7 0.1 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_25 PF13481.6 AFZ81526.1 - 0.0045 16.6 0.1 0.0084 15.7 0.1 1.4 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 AFZ81526.1 - 0.0065 16.2 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_2 PF07724.14 AFZ81526.1 - 0.0067 16.6 0.1 0.15 12.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) TsaE PF02367.17 AFZ81526.1 - 0.0073 16.3 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 AFZ81526.1 - 0.0077 16.3 0.0 0.23 11.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 AFZ81526.1 - 0.0086 16.0 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_33 PF13671.6 AFZ81526.1 - 0.0097 16.1 0.0 0.025 14.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AFZ81526.1 - 0.011 16.2 0.0 0.026 15.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 AFZ81526.1 - 0.011 15.7 0.1 0.074 13.1 0.1 2.1 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit RNA_helicase PF00910.22 AFZ81526.1 - 0.015 15.7 0.0 0.04 14.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Zeta_toxin PF06414.12 AFZ81526.1 - 0.019 14.3 0.2 0.034 13.4 0.2 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_7 PF12775.7 AFZ81526.1 - 0.025 14.1 0.0 0.062 12.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region APS_kinase PF01583.20 AFZ81526.1 - 0.027 14.4 0.1 0.061 13.2 0.1 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase Rad17 PF03215.15 AFZ81526.1 - 0.027 14.4 0.2 0.065 13.2 0.0 1.7 2 0 0 2 2 1 0 Rad17 P-loop domain PhoH PF02562.16 AFZ81526.1 - 0.031 13.7 0.1 0.08 12.4 0.1 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_19 PF13245.6 AFZ81526.1 - 0.033 14.5 0.3 0.21 11.9 0.3 2.1 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 AFZ81526.1 - 0.034 13.8 0.0 0.29 10.8 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_29 PF13555.6 AFZ81526.1 - 0.037 13.8 0.2 0.072 12.8 0.2 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSE PF00437.20 AFZ81526.1 - 0.05 12.7 0.0 0.083 11.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase_2 PF01637.18 AFZ81526.1 - 0.052 13.5 0.2 0.15 11.9 0.0 1.8 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea DNA_pol3_delta2 PF13177.6 AFZ81526.1 - 0.1 12.4 0.1 0.44 10.3 0.1 2.2 1 1 0 1 1 1 0 DNA polymerase III, delta subunit Cytidylate_kin PF02224.18 AFZ81526.1 - 0.13 12.0 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 Cytidylate kinase AAA_30 PF13604.6 AFZ81526.1 - 0.13 12.0 0.1 1.8 8.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain RtcB PF01139.17 AFZ81528.1 - 2.3e-145 484.9 0.3 3.4e-145 484.3 0.2 1.3 2 0 0 2 2 2 1 tRNA-splicing ligase RtcB DUF563 PF04577.14 AFZ81528.1 - 0.078 13.1 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF563) CoA_binding PF02629.19 AFZ81529.1 - 3.5e-25 88.5 0.9 2.5e-24 85.8 0.0 2.4 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 AFZ81529.1 - 4.3e-21 75.3 0.2 7e-21 74.6 0.2 1.4 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 AFZ81529.1 - 5.4e-11 42.4 0.0 9.4e-11 41.7 0.0 1.3 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain GFO_IDH_MocA PF01408.22 AFZ81529.1 - 0.13 13.1 0.0 0.59 11.0 0.0 1.9 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Pkinase PF00069.25 AFZ81530.1 - 5.6e-68 229.2 0.4 6.9e-68 228.9 0.4 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ81530.1 - 1.7e-24 86.5 0.0 2.3e-24 86.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 AFZ81530.1 - 3.2e-09 37.1 0.0 1.1e-06 28.8 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 AFZ81530.1 - 0.00037 19.4 0.0 0.0024 16.7 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Choline_kinase PF01633.20 AFZ81530.1 - 0.0081 15.8 0.1 0.016 14.8 0.1 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.14 AFZ81530.1 - 0.016 14.6 0.1 0.026 13.9 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 AFZ81530.1 - 0.026 14.1 1.3 0.11 12.1 1.3 2.0 1 1 0 1 1 1 0 RIO1 family Aconitase_B_N PF11791.8 AFZ81530.1 - 0.057 13.5 0.0 0.56 10.3 0.0 2.1 2 0 0 2 2 2 0 Aconitate B N-terminal domain HSP70 PF00012.20 AFZ81531.1 - 8.3e-241 800.4 11.8 9.5e-241 800.2 11.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AFZ81531.1 - 2.2e-22 79.3 2.3 6.6e-22 77.7 0.7 2.0 2 0 0 2 2 2 1 MreB/Mbl protein Radial_spoke_3 PF06098.11 AFZ81531.1 - 0.004 16.5 1.1 0.004 16.5 1.1 1.7 2 0 0 2 2 2 1 Radial spoke protein 3 FtsA PF14450.6 AFZ81531.1 - 0.052 14.0 8.9 3.1 8.3 0.4 3.6 3 2 0 3 3 3 0 Cell division protein FtsA PTPA PF03095.15 AFZ81531.1 - 0.057 12.9 1.6 0.068 12.6 0.3 1.7 2 0 0 2 2 2 0 Phosphotyrosyl phosphate activator (PTPA) protein FGGY_C PF02782.16 AFZ81531.1 - 0.13 11.9 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain FIVAR PF07554.13 AFZ81531.1 - 0.48 11.2 8.8 0.68 10.7 0.1 3.5 3 0 0 3 3 3 0 FIVAR domain DUF1712 PF08217.11 AFZ81532.1 - 4.9e-12 45.1 2.2 1e-11 44.1 2.2 1.6 1 1 0 1 1 1 1 Fungal domain of unknown function (DUF1712) TPR_1 PF00515.28 AFZ81533.1 - 3.8e-05 23.3 0.7 0.0012 18.5 0.0 3.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 AFZ81533.1 - 0.0022 18.2 0.5 0.81 10.2 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 AFZ81533.1 - 0.006 16.6 1.7 0.053 13.6 0.0 3.5 5 0 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 AFZ81533.1 - 0.017 15.3 1.7 0.038 14.2 1.7 1.8 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 DnaJ PF00226.31 AFZ81534.1 - 1.3e-20 73.2 1.8 2.7e-20 72.2 1.8 1.6 1 0 0 1 1 1 1 DnaJ domain Thioredoxin PF00085.20 AFZ81534.1 - 0.00052 20.0 0.0 0.0017 18.3 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin SH3_17 PF18350.1 AFZ81534.1 - 0.031 14.1 0.5 0.11 12.4 0.1 2.2 2 0 0 2 2 2 0 Restriction endonuclease SH3 domain Acetyltransf_1 PF00583.25 AFZ81535.1 - 6.7e-12 45.7 0.0 1.4e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AFZ81535.1 - 3.8e-07 30.4 0.0 1.2e-06 28.9 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AFZ81535.1 - 1.5e-05 24.9 0.0 3.3e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 AFZ81535.1 - 0.00023 21.3 0.1 0.00044 20.4 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 AFZ81535.1 - 0.025 15.2 0.0 0.042 14.5 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF1129 PF06570.11 AFZ81535.1 - 0.087 12.3 1.6 0.1 12.1 0.8 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Hairy_orange PF07527.13 AFZ81535.1 - 0.18 12.1 0.2 0.56 10.5 0.2 1.8 1 0 0 1 1 1 0 Hairy Orange His_Phos_1 PF00300.22 AFZ81536.1 - 1.9e-38 132.1 0.0 6.4e-28 97.8 0.0 2.0 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Hydrolase_4 PF12146.8 AFZ81537.1 - 1.3e-07 31.1 0.0 5.7e-06 25.8 0.0 2.1 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 AFZ81537.1 - 2.6e-07 30.3 0.0 2e-05 24.2 0.0 2.9 2 1 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 AFZ81537.1 - 0.00038 20.2 0.1 0.0038 16.9 0.1 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 AFZ81537.1 - 0.0014 18.5 0.1 0.0076 16.1 0.1 2.0 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase DUF818 PF05677.12 AFZ81537.1 - 0.0025 16.8 0.3 0.004 16.2 0.3 1.3 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Abhydrolase_6 PF12697.7 AFZ81537.1 - 0.024 15.2 0.0 0.035 14.7 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family AP2 PF00847.20 AFZ81538.1 - 7.2e-08 32.5 4.4 0.0056 16.9 0.1 5.1 5 0 0 5 5 5 2 AP2 domain PEPcase_2 PF14010.6 AFZ81538.1 - 0.16 10.4 0.0 0.3 9.5 0.0 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase T2SSG PF08334.11 AFZ81539.1 - 0.091 12.8 1.1 0.82 9.8 0.5 2.4 2 1 1 3 3 3 0 Type II secretion system (T2SS), protein G Sel1 PF08238.12 AFZ81540.1 - 2.3e-27 94.8 6.1 1.1e-05 25.9 0.0 9.2 10 0 0 10 10 10 6 Sel1 repeat TPR_6 PF13174.6 AFZ81540.1 - 3.3e-07 30.5 0.2 1.1 10.1 0.0 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 AFZ81540.1 - 0.00055 19.8 1.1 5 7.4 0.1 5.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 AFZ81540.1 - 0.0017 19.0 0.0 35 5.6 0.0 5.1 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 AFZ81540.1 - 0.0024 18.3 3.3 9.1 6.9 0.7 5.1 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_8 PF13181.6 AFZ81540.1 - 0.051 13.8 12.2 21 5.6 0.1 7.2 8 0 0 8 8 8 0 Tetratricopeptide repeat LHH PF14411.6 AFZ81540.1 - 0.076 13.2 0.2 0.26 11.5 0.2 1.9 1 0 0 1 1 1 0 A nuclease of the HNH/ENDO VII superfamily with conserved LHH TPR_2 PF07719.17 AFZ81540.1 - 1.5 9.1 13.1 45 4.5 0.0 7.5 9 0 0 9 9 9 0 Tetratricopeptide repeat SART-1 PF03343.13 AFZ81542.1 - 1.1e-39 136.5 26.1 3.6e-22 78.7 22.3 3.5 1 1 1 2 2 2 2 SART-1 family BSD PF03909.17 AFZ81543.1 - 0.00035 20.5 0.1 0.008 16.2 0.1 2.8 2 0 0 2 2 2 1 BSD domain Com_YlbF PF06133.11 AFZ81543.1 - 0.065 13.8 0.8 0.82 10.3 0.0 3.0 3 0 0 3 3 3 0 Control of competence regulator ComK, YlbF/YmcA TUDOR PF00567.24 AFZ81544.1 - 0.00015 21.7 0.4 0.0014 18.6 0.1 2.6 1 1 1 2 2 2 1 Tudor domain Agenet PF05641.12 AFZ81544.1 - 0.027 15.0 0.1 0.07 13.6 0.1 1.8 1 0 0 1 1 1 0 Agenet domain Enolase_C PF00113.22 AFZ81545.1 - 2.4e-148 493.2 0.0 3.4e-148 492.7 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 AFZ81545.1 - 1.8e-53 180.2 0.0 2.8e-53 179.6 0.0 1.3 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 AFZ81545.1 - 1.8e-08 34.2 0.0 4.1e-08 33.1 0.0 1.6 2 0 0 2 2 2 1 Enolase C-terminal domain-like MAAL_C PF07476.11 AFZ81545.1 - 5.2e-06 25.8 0.0 8.7e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus UPRTase PF14681.6 AFZ81545.1 - 0.013 14.9 0.0 0.031 13.7 0.0 1.6 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase B-block_TFIIIC PF04182.12 AFZ81548.1 - 1.8e-19 69.7 3.2 8.7e-18 64.3 0.3 3.6 3 0 0 3 3 3 2 B-block binding subunit of TFIIIC TrmB PF01978.19 AFZ81548.1 - 0.0015 18.3 1.6 0.49 10.3 0.2 4.6 5 0 0 5 5 5 1 Sugar-specific transcriptional regulator TrmB TFIIE_alpha PF02002.17 AFZ81548.1 - 0.28 11.0 2.4 3.9 7.4 0.0 3.7 4 0 0 4 4 4 0 TFIIE alpha subunit Maf PF02545.14 AFZ81549.1 - 4.8e-35 120.9 0.0 5.8e-35 120.6 0.0 1.1 1 0 0 1 1 1 1 Maf-like protein eIF3_p135 PF12807.7 AFZ81550.1 - 1.2e-05 25.4 0.0 2.4e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 CLU PF13236.6 AFZ81550.1 - 0.004 17.0 0.0 0.0072 16.2 0.0 1.3 1 0 0 1 1 1 1 Clustered mitochondria TPR_12 PF13424.6 AFZ81550.1 - 0.0046 17.2 0.2 0.14 12.5 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 AFZ81550.1 - 0.075 12.9 1.9 0.44 10.4 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 AFZ81550.1 - 0.13 12.4 0.1 1.4 9.2 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Stevor PF17410.2 AFZ81551.1 - 3.2 7.2 11.0 0.14 11.7 1.7 3.3 2 1 1 3 3 3 0 Subtelomeric Variable Open Reading frame DEAD PF00270.29 AFZ81552.1 - 7.5e-15 55.1 0.0 1.5e-14 54.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 AFZ81552.1 - 0.0016 18.4 1.1 0.01 15.8 0.1 2.6 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Ribosomal_60s PF00428.19 AFZ81553.1 - 2.3e-21 76.2 3.5 3.1e-21 75.8 3.5 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein Cytochrom_C PF00034.21 AFZ81554.1 - 4.8e-08 34.0 0.0 6.9e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 AFZ81554.1 - 0.00014 22.1 0.3 0.00023 21.4 0.3 1.7 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 AFZ81554.1 - 0.00032 20.4 0.0 0.022 14.5 0.0 2.3 2 0 0 2 2 2 2 Cytochrome c-550 domain Cytochrom_C1 PF02167.15 AFZ81554.1 - 0.012 15.3 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 Cytochrome C1 family ATP-synt_ab PF00006.25 AFZ81556.1 - 6.6e-99 329.9 0.0 8.9e-99 329.4 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 AFZ81556.1 - 3.3e-37 127.0 0.0 6.4e-37 126.1 0.0 1.5 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 AFZ81556.1 - 5.7e-16 58.8 1.6 8.8e-16 58.2 0.3 2.0 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain GYF PF02213.16 AFZ81557.1 - 8.5e-05 22.2 1.0 0.00021 20.9 1.0 1.7 1 0 0 1 1 1 1 GYF domain AAA_11 PF13086.6 AFZ81558.1 - 1.6e-61 208.4 0.0 4.3e-30 105.4 0.2 2.7 1 1 1 2 2 2 2 AAA domain AAA_12 PF13087.6 AFZ81558.1 - 3.5e-60 203.0 0.1 6.4e-60 202.2 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AFZ81558.1 - 7.6e-08 32.8 0.0 0.0055 17.0 0.1 2.6 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 AFZ81558.1 - 1.1e-07 31.7 0.0 0.00018 21.3 0.0 2.7 2 1 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 AFZ81558.1 - 1.7e-06 28.0 0.1 0.0066 16.2 0.0 3.6 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_23 PF13476.6 AFZ81558.1 - 0.0015 19.0 0.4 0.0066 17.0 0.4 2.1 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 AFZ81558.1 - 0.0058 16.4 0.0 1.3 8.9 0.0 2.5 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA PF00004.29 AFZ81558.1 - 0.035 14.5 0.0 0.086 13.3 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 AFZ81558.1 - 0.11 12.2 0.2 6.6 6.4 0.0 2.7 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 AFZ81558.1 - 0.15 11.8 0.2 0.37 10.6 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ResIII PF04851.15 AFZ81558.1 - 0.36 10.8 1.5 1.7 8.6 0.1 2.9 4 0 0 4 4 4 0 Type III restriction enzyme, res subunit Acetyltransf_1 PF00583.25 AFZ81559.1 - 2.2e-07 31.1 0.0 2.9e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AFZ81559.1 - 1.2e-05 25.7 0.0 1.8e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AFZ81559.1 - 0.0002 21.3 0.0 0.00033 20.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain COG5 PF10392.9 AFZ81560.1 - 0.0022 18.2 2.1 0.0092 16.2 2.1 2.0 1 1 0 1 1 1 1 Golgi transport complex subunit 5 Prominin PF05478.11 AFZ81560.1 - 0.0031 15.6 1.0 0.0031 15.6 1.0 1.6 2 0 0 2 2 2 1 Prominin APG17 PF04108.12 AFZ81560.1 - 0.03 13.4 1.9 0.083 12.0 0.5 1.9 2 0 0 2 2 2 0 Autophagy protein Apg17 DUF5617 PF18493.1 AFZ81560.1 - 0.12 12.5 1.5 0.54 10.4 0.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF5617) Tweety PF04906.13 AFZ81560.1 - 0.57 8.8 3.6 0.27 9.9 0.7 1.7 2 0 0 2 2 2 0 Tweety Baculo_PEP_C PF04513.12 AFZ81560.1 - 0.73 9.9 15.2 0.32 11.0 8.6 2.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Latarcin PF10279.9 AFZ81560.1 - 3.4 8.1 5.6 5.8 7.4 2.2 2.7 2 1 0 2 2 2 0 Latarcin precursor SNARE PF05739.19 AFZ81560.1 - 8 6.5 7.8 0.5 10.4 0.2 2.4 2 0 0 2 2 2 0 SNARE domain E1_dh PF00676.20 AFZ81561.1 - 1.1e-84 283.9 0.0 1.3e-84 283.7 0.0 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component RE_EcoO109I PF14511.6 AFZ81562.1 - 0.048 13.3 0.0 0.072 12.7 0.0 1.2 1 0 0 1 1 1 0 Type II restriction endonuclease EcoO109I RRM_1 PF00076.22 AFZ81567.1 - 4.1e-11 42.5 0.0 5.3e-11 42.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 AFZ81567.1 - 0.023 14.3 0.0 0.029 14.0 0.0 1.1 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 AFZ81567.1 - 0.038 14.1 0.0 0.066 13.3 0.0 1.4 1 0 0 1 1 1 0 Limkain b1 RRM_occluded PF16842.5 AFZ81567.1 - 0.084 12.7 0.0 0.15 11.9 0.0 1.4 1 1 0 1 1 1 0 Occluded RNA-recognition motif Imm50 PF15594.6 AFZ81567.1 - 0.13 12.5 0.0 0.15 12.3 0.0 1.2 1 0 0 1 1 1 0 Immunity protein 50 SDF PF00375.18 AFZ81568.1 - 7.5e-19 68.0 11.8 1.1e-18 67.5 11.8 1.1 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family SNAD1 PF18744.1 AFZ81569.1 - 0.022 14.6 0.0 0.038 13.8 0.0 1.3 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 1 DEAD PF00270.29 AFZ81570.1 - 6.5e-21 74.9 0.0 1.1e-20 74.1 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AFZ81570.1 - 1.8e-18 66.9 0.1 5e-18 65.5 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AFZ81570.1 - 0.0019 18.3 0.0 0.0038 17.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Peptidase_S64 PF08192.11 AFZ81570.1 - 0.015 13.8 0.3 0.021 13.3 0.3 1.2 1 0 0 1 1 1 0 Peptidase family S64 YEATS PF03366.16 AFZ81571.1 - 1.5e-25 89.0 0.1 3.8e-25 87.7 0.0 1.7 2 0 0 2 2 2 1 YEATS family TelA PF05816.11 AFZ81572.1 - 0.0037 16.4 2.0 0.0062 15.6 2.0 1.3 1 0 0 1 1 1 1 Toxic anion resistance protein (TelA) Muted PF14942.6 AFZ81572.1 - 0.023 15.0 4.7 4 7.8 0.1 2.7 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein V_ATPase_I PF01496.19 AFZ81573.1 - 9.4e-240 797.8 11.7 1.1e-239 797.6 11.7 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family MMR_HSR1 PF01926.23 AFZ81574.1 - 9.4e-19 67.6 0.0 1.8e-18 66.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 AFZ81574.1 - 5.4e-05 23.3 0.1 0.14 12.2 0.0 2.6 2 0 0 2 2 2 2 Dynamin family SRPRB PF09439.10 AFZ81574.1 - 0.00024 20.6 1.2 0.00058 19.3 0.1 2.2 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 AFZ81574.1 - 0.00051 19.6 0.7 0.00087 18.9 0.1 1.7 2 1 0 2 2 2 1 Ferrous iron transport protein B Septin PF00735.18 AFZ81574.1 - 0.0021 17.4 0.0 0.0041 16.4 0.0 1.4 1 0 0 1 1 1 1 Septin RsgA_GTPase PF03193.16 AFZ81574.1 - 0.0057 16.6 0.0 0.016 15.2 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase AIG1 PF04548.16 AFZ81574.1 - 0.014 14.8 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 AIG1 family IIGP PF05049.13 AFZ81574.1 - 0.015 14.4 0.1 0.044 12.8 0.1 1.8 1 1 0 1 1 1 0 Interferon-inducible GTPase (IIGP) GTP_EFTU PF00009.27 AFZ81574.1 - 0.028 13.9 0.0 0.37 10.3 0.0 2.2 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain RNA_helicase PF00910.22 AFZ81574.1 - 0.046 14.1 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Roc PF08477.13 AFZ81574.1 - 0.06 13.6 0.1 0.2 11.9 0.1 1.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 AFZ81574.1 - 0.12 12.8 0.1 0.52 10.8 0.0 2.1 2 0 0 2 2 2 0 ABC transporter CLP1_P PF16575.5 AFZ81574.1 - 0.14 11.9 0.1 0.41 10.4 0.0 1.8 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Ribosomal_L3 PF00297.22 AFZ81575.1 - 5.1e-09 35.6 7.2 5.1e-08 32.3 1.9 2.9 2 2 1 3 3 3 2 Ribosomal protein L3 EMC1_C PF07774.13 AFZ81577.1 - 2.5e-30 105.8 4.3 5.3e-30 104.7 4.3 1.6 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal Nucleoporin_FG PF13634.6 AFZ81578.1 - 2.3e-58 195.0 362.6 4.1e-11 43.6 40.8 7.5 1 1 7 9 9 9 9 Nucleoporin FG repeat region Nucleoporin2 PF04096.14 AFZ81578.1 - 2.3e-24 86.2 0.0 3.7e-24 85.5 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin autopeptidase Ribosomal_S21e PF01249.18 AFZ81579.1 - 3.6e-34 116.7 0.1 3.9e-34 116.6 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e Img2 PF05046.14 AFZ81580.1 - 1.1e-20 73.7 0.0 1.6e-20 73.2 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) Peptidase_M24 PF00557.24 AFZ81581.1 - 4.8e-45 153.8 0.0 7.2e-45 153.2 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N_2 PF16189.5 AFZ81581.1 - 7.5e-36 123.7 0.2 1.5e-35 122.7 0.2 1.6 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Creatinase_N PF01321.18 AFZ81581.1 - 1.1e-22 81.0 0.0 7.5e-21 75.2 0.0 2.3 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 AFZ81581.1 - 2.9e-16 59.3 0.2 6.4e-16 58.2 0.2 1.6 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 eIF-3c_N PF05470.12 AFZ81582.1 - 3.6e-100 336.0 40.9 1.9e-98 330.3 40.9 2.1 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 AFZ81582.1 - 3e-11 43.8 6.5 6.7e-11 42.6 0.3 3.6 3 0 0 3 3 3 1 PCI domain SR-25 PF10500.9 AFZ81582.1 - 0.084 12.5 15.8 0.37 10.4 13.4 2.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein U3snoRNP10 PF12397.8 AFZ81582.1 - 0.59 10.5 6.5 10 6.5 0.8 3.8 3 1 0 3 3 3 0 U3 small nucleolar RNA-associated protein 10 DUF1512 PF07431.12 AFZ81582.1 - 1.2 8.1 9.1 0.78 8.7 3.3 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1512) DUF4250 PF14056.6 AFZ81582.1 - 1.7 8.7 4.7 2.2 8.3 0.5 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4250) tRNA-synt_1 PF00133.22 AFZ81583.1 - 8.3e-188 625.4 0.0 9.5e-187 621.9 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 AFZ81583.1 - 5.6e-36 123.8 0.0 1.7e-35 122.3 0.0 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 AFZ81583.1 - 3.6e-15 55.6 2.2 7.9e-07 28.2 0.0 4.6 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 AFZ81583.1 - 2.2e-08 33.8 0.2 6.2e-07 29.1 0.0 2.5 1 1 1 2 2 2 1 Leucyl-tRNA synthetase, Domain 2 Val_tRNA-synt_C PF10458.9 AFZ81583.1 - 0.00053 20.2 0.1 0.0014 18.8 0.1 1.8 1 0 0 1 1 1 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1b PF00579.25 AFZ81583.1 - 0.005 16.2 0.5 0.023 14.0 0.1 2.1 2 0 0 2 2 2 1 tRNA synthetases class I (W and Y) tRNA-synt_1c PF00749.21 AFZ81583.1 - 0.012 14.6 0.1 0.083 11.8 0.0 2.3 2 1 1 3 3 3 0 tRNA synthetases class I (E and Q), catalytic domain Phage_tail_APC PF16778.5 AFZ81584.1 - 0.089 12.7 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Phage tail assembly chaperone protein SPAN-X PF07458.12 AFZ81585.1 - 0.12 12.8 0.2 0.17 12.4 0.2 1.3 1 0 0 1 1 1 0 Sperm protein associated with nucleus, mapped to X chromosome Rad9 PF04139.13 AFZ81587.1 - 1e-19 71.0 0.2 2.3e-19 69.8 0.2 1.6 1 0 0 1 1 1 1 Rad9 RimM PF01782.18 AFZ81587.1 - 2.7e-14 53.2 0.0 5.8e-14 52.1 0.0 1.6 1 0 0 1 1 1 1 RimM N-terminal domain zf-C2H2_6 PF13912.6 AFZ81587.1 - 0.0093 16.0 1.2 0.018 15.0 1.2 1.5 1 0 0 1 1 1 1 C2H2-type zinc finger F-box PF00646.33 AFZ81588.1 - 0.00074 19.3 0.0 0.0036 17.1 0.0 2.2 1 0 0 1 1 1 1 F-box domain Xol-1_GHMP-like PF09109.10 AFZ81589.1 - 0.015 15.2 0.1 0.038 13.9 0.1 1.7 1 0 0 1 1 1 0 Switch protein XOL-1, GHMP-like Cyclin_N PF00134.23 AFZ81589.1 - 0.1 12.4 0.4 0.5 10.1 0.0 2.2 2 1 1 3 3 3 0 Cyclin, N-terminal domain Ribosomal_S2 PF00318.20 AFZ81590.1 - 5e-29 101.1 0.6 6.1e-15 55.0 0.2 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 AFZ81590.1 - 0.0013 20.0 0.3 0.0027 19.0 0.3 1.5 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus PPI_Ypi1 PF07491.11 AFZ81591.1 - 1.1e-14 53.9 9.9 1.9e-14 53.2 9.9 1.3 1 0 0 1 1 1 1 Protein phosphatase inhibitor Ferritin PF00210.24 AFZ81593.1 - 0.011 15.7 0.7 0.02 14.8 0.1 1.7 2 0 0 2 2 2 0 Ferritin-like domain Pox_polyA_pol_C PF12629.7 AFZ81593.1 - 0.012 15.4 3.0 0.024 14.5 3.0 1.5 1 1 0 1 1 1 0 Poxvirus poly(A) polymerase C-terminal domain 60KD_IMP PF02096.20 AFZ81593.1 - 4.9 7.0 5.8 4.1 7.3 0.1 2.1 2 0 0 2 2 2 0 60Kd inner membrane protein Surp PF01805.20 AFZ81594.1 - 1.2e-19 70.0 0.2 2.5e-19 69.0 0.2 1.5 1 0 0 1 1 1 1 Surp module Baculo_LEF-11 PF06385.12 AFZ81594.1 - 0.068 13.7 1.0 0.44 11.1 0.2 2.2 2 0 0 2 2 2 0 Baculovirus LEF-11 protein Chordopox_A13L PF05961.11 AFZ81595.1 - 0.39 11.0 1.9 0.45 10.8 0.2 2.0 2 1 1 3 3 3 0 Chordopoxvirus A13L protein Ribosomal_S27 PF01599.19 AFZ81596.1 - 2.7e-22 78.6 1.8 2.7e-22 78.6 1.8 1.9 2 0 0 2 2 2 1 Ribosomal protein S27a zf-U1 PF06220.12 AFZ81597.1 - 2e-05 24.3 0.6 4.4e-05 23.2 0.6 1.6 1 0 0 1 1 1 1 U1 zinc finger WW PF00397.26 AFZ81597.1 - 0.0027 17.7 6.0 0.041 14.0 2.0 2.6 2 0 0 2 2 2 2 WW domain SAC3_GANP PF03399.16 AFZ81600.1 - 2.6e-45 155.1 5.2 1.7e-43 149.1 5.2 2.6 1 1 0 1 1 1 1 SAC3/GANP family DCP1 PF06058.13 AFZ81601.1 - 4.1e-31 107.3 1.1 6.8e-31 106.6 1.1 1.4 1 0 0 1 1 1 1 Dcp1-like decapping family RNA_pol_Rpb1_3 PF04983.18 AFZ81601.1 - 0.085 12.8 4.7 0.18 11.7 2.4 2.1 1 1 1 2 2 2 0 RNA polymerase Rpb1, domain 3 DUF1910 PF08928.10 AFZ81601.1 - 0.26 11.3 2.1 0.45 10.5 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF1910) ATPase_2 PF01637.18 AFZ81602.1 - 0.0053 16.7 3.6 0.0091 15.9 0.1 2.4 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 AFZ81602.1 - 0.0079 16.6 0.2 0.048 14.1 0.0 2.5 2 1 0 2 2 2 1 RNA helicase RsgA_GTPase PF03193.16 AFZ81602.1 - 0.0092 15.9 0.0 0.028 14.3 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 AFZ81602.1 - 0.016 15.6 0.0 0.047 14.1 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 AFZ81602.1 - 0.033 14.1 0.0 0.087 12.7 0.0 1.7 2 0 0 2 2 2 0 NACHT domain AAA_22 PF13401.6 AFZ81602.1 - 0.035 14.4 0.0 0.099 12.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF2977 PF11192.8 AFZ81602.1 - 0.052 13.7 0.4 0.22 11.7 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2977) AAA_29 PF13555.6 AFZ81602.1 - 0.066 13.0 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 AFZ81602.1 - 0.07 13.1 0.0 13 5.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) T2SSE PF00437.20 AFZ81602.1 - 0.08 12.0 0.0 0.52 9.3 0.0 2.1 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA PF00004.29 AFZ81602.1 - 0.11 13.0 0.0 0.93 9.9 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) PIGA PF08288.12 AFZ81603.1 - 7.5e-33 113.0 0.0 1.8e-32 111.7 0.0 1.7 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glycos_transf_1 PF00534.20 AFZ81603.1 - 3.6e-28 98.2 0.0 5.5e-28 97.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 AFZ81603.1 - 8.6e-25 87.7 0.0 1.6e-24 86.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 AFZ81603.1 - 1.4e-21 77.4 0.0 2.5e-21 76.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 AFZ81603.1 - 2.9e-07 31.1 0.0 7.5e-07 29.7 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 AFZ81603.1 - 6e-05 23.1 0.0 0.00012 22.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like Imm8 PF15586.6 AFZ81603.1 - 0.01 15.9 0.0 0.024 14.7 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 8 Glyco_trans_1_2 PF13524.6 AFZ81603.1 - 0.021 15.2 0.0 0.043 14.2 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 PCI PF01399.27 AFZ81605.1 - 5.6e-18 65.4 2.0 1.3e-17 64.2 0.8 2.4 2 0 0 2 2 2 1 PCI domain RPN6_N PF18055.1 AFZ81605.1 - 1.1e-09 38.6 0.0 3.4e-09 37.1 0.0 1.8 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN6 N-terminal domain RPN6_C_helix PF18503.1 AFZ81605.1 - 0.048 13.4 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 26S proteasome subunit RPN6 C-terminal helix domain DUF4470 PF14737.6 AFZ81605.1 - 0.22 11.7 1.1 2.3 8.4 0.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4470) TFIID-31kDa PF02291.15 AFZ81606.1 - 1.6e-06 28.2 0.3 2.3e-06 27.7 0.3 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit DER1 PF04511.15 AFZ81607.1 - 7.7e-35 120.6 13.8 9e-35 120.3 13.8 1.1 1 0 0 1 1 1 1 Der1-like family RRM_1 PF00076.22 AFZ81608.1 - 1.4e-31 108.1 0.9 1.5e-15 56.7 0.1 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AFZ81608.1 - 5.1e-09 36.1 0.1 0.0028 17.7 0.0 3.1 2 1 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 AFZ81608.1 - 0.0015 18.5 0.1 0.025 14.6 0.0 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif UCH PF00443.29 AFZ81609.1 - 2.5e-39 135.3 0.2 3.5e-39 134.8 0.2 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 AFZ81609.1 - 2.4e-09 36.8 0.0 9.9e-09 34.8 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin family UCH_1 PF13423.6 AFZ81609.1 - 5.2e-06 26.3 1.2 0.0031 17.2 1.2 2.8 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_2 PF14560.6 AFZ81609.1 - 0.0047 17.3 0.0 0.012 16.0 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-like domain GYF PF02213.16 AFZ81610.1 - 0.0092 15.6 0.0 0.02 14.5 0.0 1.6 1 0 0 1 1 1 1 GYF domain Peptidase_M24 PF00557.24 AFZ81611.1 - 4.2e-42 144.2 0.0 5.1e-42 143.9 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 EF-hand_1 PF00036.32 AFZ81612.1 - 2.9e-13 48.3 2.6 3.4e-07 29.4 0.3 3.9 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 AFZ81612.1 - 2.6e-12 45.6 3.0 1.6e-05 24.4 0.6 4.4 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 AFZ81612.1 - 2.7e-12 46.9 1.9 2.3e-08 34.3 1.1 3.1 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 AFZ81612.1 - 2.5e-08 33.1 4.2 3.8e-06 26.1 0.9 3.2 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 AFZ81612.1 - 0.00023 21.0 0.0 0.06 13.2 0.0 3.2 3 0 0 3 3 3 1 EF-hand domain pair UPF0154 PF03672.13 AFZ81612.1 - 0.041 13.9 0.0 0.12 12.5 0.0 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) HEPN_RiboL-PSP PF18735.1 AFZ81612.1 - 0.28 11.1 4.9 0.76 9.7 3.3 2.0 1 1 1 2 2 2 0 RiboL-PSP-HEPN Ribosomal_L26 PF16906.5 AFZ81613.1 - 9.2e-37 125.4 7.2 1.2e-36 125.0 7.2 1.1 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 AFZ81613.1 - 6.4e-08 32.3 0.8 1.2e-07 31.4 0.8 1.5 1 0 0 1 1 1 1 KOW motif DUF5301 PF17225.3 AFZ81613.1 - 0.017 15.5 0.2 0.035 14.5 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF5300) WD40 PF00400.32 AFZ81614.1 - 4e-12 46.4 6.9 5.8e-06 26.9 0.1 4.5 4 0 0 4 4 4 2 WD domain, G-beta repeat DUF1899 PF08953.11 AFZ81614.1 - 1.8e-10 40.6 0.0 5.5e-10 39.0 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) ANAPC4_WD40 PF12894.7 AFZ81614.1 - 4.3e-07 30.1 0.2 0.028 14.7 0.0 3.3 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AFZ81614.1 - 0.0086 16.0 0.0 0.062 13.2 0.1 2.1 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 AFZ81614.1 - 0.013 14.4 0.0 0.025 13.6 0.0 1.4 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein VCBS PF13517.6 AFZ81614.1 - 0.22 12.2 3.8 0.9 10.2 1.3 3.1 2 1 1 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DEAD PF00270.29 AFZ81617.1 - 3.2e-45 154.0 0.1 6.1e-45 153.1 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AFZ81617.1 - 4.4e-28 97.8 0.3 2.6e-25 88.9 0.0 3.4 3 0 0 3 3 3 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 AFZ81617.1 - 0.049 13.9 0.1 1.7 8.9 0.1 2.5 2 0 0 2 2 2 0 AAA domain tRNA-synt_1b PF00579.25 AFZ81619.1 - 1.2e-34 120.0 0.4 1.5e-34 119.6 0.4 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Pkinase PF00069.25 AFZ81620.1 - 1.3e-50 172.2 0.0 2.3e-50 171.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ81620.1 - 6.2e-25 88.0 0.0 1.1e-24 87.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AFZ81620.1 - 0.00033 20.1 0.0 0.00052 19.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like AvrM-A PF18241.1 AFZ81620.1 - 0.021 15.2 1.5 0.021 15.2 1.5 1.9 2 0 0 2 2 2 0 Flax-rust effector AvrM-A G10 PF01125.17 AFZ81620.1 - 0.81 9.4 12.3 0.33 10.7 3.0 2.5 1 1 0 2 2 2 0 G10 protein PHM7_cyt PF14703.6 AFZ81622.1 - 1.5e-09 38.4 1.7 1.1e-06 29.0 0.1 2.6 3 0 0 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter TFIIA_gamma_N PF02268.16 AFZ81625.1 - 0.074 13.1 0.3 0.13 12.3 0.3 1.4 1 0 0 1 1 1 0 Transcription initiation factor IIA, gamma subunit, helical domain WXG100 PF06013.12 AFZ81626.1 - 0.063 13.5 0.1 40 4.5 0.0 3.9 3 0 0 3 3 3 0 Proteins of 100 residues with WXG LPP PF04728.13 AFZ81626.1 - 0.08 13.3 1.0 5.6 7.4 0.2 4.2 4 1 0 4 4 4 0 Lipoprotein leucine-zipper Syntaxin-6_N PF09177.11 AFZ81626.1 - 0.92 10.1 19.5 5.6 7.6 1.6 4.2 2 2 1 3 3 3 0 Syntaxin 6, N-terminal ADIP PF11559.8 AFZ81626.1 - 4.7 7.3 32.4 0.17 12.0 8.7 4.1 2 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding Vps26 PF03643.15 AFZ81627.1 - 2.2e-85 286.0 3.5 2.6e-85 285.8 3.5 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Helicase_C_2 PF13307.6 AFZ81629.1 - 9.9e-51 172.3 0.2 4.1e-50 170.3 0.0 2.2 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 AFZ81629.1 - 2.6e-48 163.9 0.7 7.2e-48 162.5 0.7 1.8 1 0 0 1 1 1 1 DEAD_2 DEAD PF00270.29 AFZ81629.1 - 5.9e-06 26.2 0.4 0.00048 20.0 0.0 2.9 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.15 AFZ81629.1 - 7.8e-05 22.7 1.7 0.0033 17.5 0.1 2.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit PriA_C PF18074.1 AFZ81629.1 - 0.068 14.0 0.3 0.3 11.9 0.3 2.1 1 0 0 1 1 1 0 Primosomal protein N C-terminal domain LsmAD PF06741.13 AFZ81631.1 - 5.2e-09 36.5 0.8 1.8e-08 34.8 0.8 2.0 1 0 0 1 1 1 1 LsmAD domain SM-ATX PF14438.6 AFZ81631.1 - 2.7e-05 24.2 0.0 6.6e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM PF01423.22 AFZ81631.1 - 0.021 14.5 0.0 0.046 13.4 0.0 1.5 1 0 0 1 1 1 0 LSM domain PAM2 PF07145.15 AFZ81631.1 - 5.1 7.0 10.4 0.12 12.1 3.6 2.0 2 0 0 2 2 2 0 Ataxin-2 C-terminal region MMR_HSR1 PF01926.23 AFZ81632.1 - 5.3e-15 55.5 0.0 1.9e-14 53.7 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AFZ81632.1 - 2.6e-06 27.5 0.5 0.0093 15.9 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 AFZ81632.1 - 6.5e-06 26.3 0.2 0.055 13.5 0.4 2.4 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.27 AFZ81632.1 - 9e-05 22.1 0.0 0.12 11.9 0.0 2.9 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.16 AFZ81632.1 - 0.00061 19.2 0.0 0.0011 18.4 0.0 1.3 1 0 0 1 1 1 1 AIG1 family FeoB_N PF02421.18 AFZ81632.1 - 0.0023 17.5 0.0 0.039 13.5 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.5 AFZ81632.1 - 0.03 14.3 0.1 0.079 13.0 0.1 1.7 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Ras PF00071.22 AFZ81632.1 - 0.059 13.0 0.0 0.34 10.5 0.0 2.1 2 0 0 2 2 2 0 Ras family AAA_5 PF07728.14 AFZ81632.1 - 0.086 12.8 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) KH_2 PF07650.17 AFZ81632.1 - 0.088 12.6 0.4 0.19 11.5 0.4 1.7 1 0 0 1 1 1 0 KH domain ACDC PF14733.6 AFZ81634.1 - 3.9e-22 78.4 4.8 6.4e-22 77.7 4.8 1.3 1 0 0 1 1 1 1 AP2-coincident C-terminal AP2 PF00847.20 AFZ81634.1 - 5.3e-18 65.0 1.1 9.1e-18 64.2 1.1 1.4 1 0 0 1 1 1 1 AP2 domain Pkinase PF00069.25 AFZ81635.1 - 9.7e-12 44.8 0.0 1.5e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.25 AFZ81636.1 - 1.5e-28 99.9 0.0 1.3e-26 93.6 0.0 2.8 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ81636.1 - 6.4e-20 71.5 0.0 9.1e-15 54.6 0.0 3.0 2 1 0 2 2 2 2 Protein tyrosine kinase DUF2951 PF11166.8 AFZ81636.1 - 0.034 14.4 0.8 0.078 13.2 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) Xylo_C PF12529.8 AFZ81636.1 - 0.085 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Xylosyltransferase C terminal Trm112p PF03966.16 AFZ81637.1 - 0.001 19.6 0.0 0.0013 19.3 0.0 1.3 1 0 0 1 1 1 1 Trm112p-like protein DUF1108 PF06531.11 AFZ81637.1 - 0.088 13.1 0.0 0.12 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1108) InvH PF04741.12 AFZ81638.1 - 0.22 11.5 0.7 0.29 11.0 0.7 1.2 1 0 0 1 1 1 0 InvH outer membrane lipoprotein Tweety PF04906.13 AFZ81639.1 - 0.024 13.3 1.6 0.036 12.8 1.0 1.5 1 1 0 1 1 1 0 Tweety Clathrin_lg_ch PF01086.17 AFZ81639.1 - 0.074 13.1 1.6 0.11 12.5 1.6 1.5 1 1 0 1 1 1 0 Clathrin light chain CCDC-167 PF15188.6 AFZ81639.1 - 0.13 12.6 3.6 0.14 12.5 0.1 2.8 3 1 0 3 3 3 0 Coiled-coil domain-containing protein 167 Flagellin_C PF00700.21 AFZ81639.1 - 0.15 12.4 4.5 0.82 10.1 0.3 3.1 3 0 0 3 3 3 0 Bacterial flagellin C-terminal helical region Spectrin PF00435.21 AFZ81639.1 - 0.25 11.9 2.4 5 7.7 0.5 2.4 2 0 0 2 2 2 0 Spectrin repeat RasGAP_C PF03836.15 AFZ81639.1 - 0.71 10.0 7.3 1.7 8.8 2.4 3.0 1 1 2 3 3 3 0 RasGAP C-terminus PRP38 PF03371.15 AFZ81640.1 - 2.4e-34 118.7 3.1 3.7e-34 118.1 3.1 1.2 1 0 0 1 1 1 1 PRP38 family Fibrillarin PF01269.17 AFZ81641.1 - 1.4e-99 331.9 0.0 1.7e-99 331.5 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 AFZ81641.1 - 0.0003 20.6 0.0 0.00044 20.0 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltr_RsmB-F PF01189.17 AFZ81641.1 - 0.042 13.5 0.0 0.069 12.8 0.0 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Methyltransf_25 PF13649.6 AFZ81641.1 - 0.043 14.5 0.0 0.072 13.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain LCCL PF03815.19 AFZ81642.1 - 9.2e-81 266.1 16.0 2.5e-25 88.4 0.2 4.6 4 0 0 4 4 4 4 LCCL domain SRCR PF00530.18 AFZ81642.1 - 3.7e-35 120.4 6.5 1.5e-17 63.9 1.0 2.8 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain PLAT PF01477.23 AFZ81642.1 - 1.9e-19 70.3 3.2 2.2e-15 57.2 0.1 3.2 3 0 0 3 3 3 2 PLAT/LH2 domain Rxt3 PF08642.10 AFZ81642.1 - 1.3e-09 38.9 0.0 0.0064 17.3 0.0 3.5 2 1 0 2 2 2 2 Histone deacetylation protein Rxt3 Laminin_G_3 PF13385.6 AFZ81642.1 - 1.3e-05 25.4 0.0 3.2e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily SRCR_2 PF15494.6 AFZ81642.1 - 6.2e-05 23.5 1.3 0.48 11.0 0.3 2.9 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Radical_SAM PF04055.21 AFZ81643.1 - 6e-13 49.5 0.0 9.7e-13 48.8 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 AFZ81643.1 - 4.3e-05 23.6 0.1 0.00022 21.3 0.0 2.0 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 AFZ81643.1 - 0.015 15.5 0.0 0.033 14.5 0.0 1.6 1 0 0 1 1 1 0 4Fe-4S single cluster domain zf-C2H2_10 PF16588.5 AFZ81643.1 - 6.5 6.6 6.8 11 5.8 1.2 2.5 2 0 0 2 2 2 0 C2H2 zinc-finger DUF3273 PF11677.8 AFZ81644.1 - 1.2e-102 342.8 8.1 1.5e-102 342.5 8.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) Metallophos_2 PF12850.7 AFZ81645.1 - 2.4e-15 57.1 0.0 3.3e-15 56.7 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain AAA_2 PF07724.14 AFZ81646.1 - 1.5e-47 161.9 0.7 6.9e-47 159.7 0.0 2.5 4 0 0 4 4 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 AFZ81646.1 - 4.5e-22 77.9 0.1 1.6e-21 76.2 0.1 1.9 1 0 0 1 1 1 1 AAA lid domain AAA PF00004.29 AFZ81646.1 - 7.5e-22 78.2 0.4 2.8e-10 40.7 0.0 3.1 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 AFZ81646.1 - 7.5e-18 64.9 0.1 5.2e-12 45.9 0.0 4.1 4 1 1 5 5 4 2 AAA domain (dynein-related subfamily) ClpB_D2-small PF10431.9 AFZ81646.1 - 8.3e-17 61.0 0.0 2.6e-16 59.5 0.0 1.9 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein Clp_N PF02861.20 AFZ81646.1 - 2.8e-14 52.9 0.1 7.9e-06 25.9 0.1 2.7 2 0 0 2 2 2 2 Clp amino terminal domain, pathogenicity island component AAA_22 PF13401.6 AFZ81646.1 - 3.9e-14 53.1 0.0 5.7e-06 26.6 0.0 3.4 3 1 0 3 3 3 2 AAA domain AAA_16 PF13191.6 AFZ81646.1 - 9.1e-09 35.9 0.0 0.02 15.3 0.0 3.8 3 1 0 3 3 3 2 AAA ATPase domain Sigma54_activat PF00158.26 AFZ81646.1 - 9.2e-08 32.0 0.0 5.1e-06 26.3 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 AFZ81646.1 - 9.9e-07 28.3 0.2 0.013 14.9 0.0 3.3 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI TniB PF05621.11 AFZ81646.1 - 4e-06 26.4 0.0 0.0046 16.4 0.0 3.7 2 2 0 2 2 2 1 Bacterial TniB protein AAA_7 PF12775.7 AFZ81646.1 - 4.9e-06 26.2 0.0 0.072 12.6 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_18 PF13238.6 AFZ81646.1 - 3e-05 24.6 0.4 0.017 15.6 0.1 3.6 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 AFZ81646.1 - 3.3e-05 23.3 0.0 0.0037 16.6 0.0 2.8 3 0 0 3 3 3 1 Zeta toxin RNA_helicase PF00910.22 AFZ81646.1 - 3.3e-05 24.2 3.2 0.072 13.5 0.9 3.9 3 1 0 3 3 2 1 RNA helicase IstB_IS21 PF01695.17 AFZ81646.1 - 8.5e-05 22.3 0.1 0.51 10.1 0.0 2.7 3 0 0 3 3 2 2 IstB-like ATP binding protein RuvB_N PF05496.12 AFZ81646.1 - 0.00012 21.9 0.1 0.26 11.0 0.0 3.6 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain DNA_pol3_delta2 PF13177.6 AFZ81646.1 - 0.00016 21.5 0.1 0.93 9.3 0.0 3.0 2 0 0 2 2 2 2 DNA polymerase III, delta subunit AAA_33 PF13671.6 AFZ81646.1 - 0.0014 18.8 0.0 0.095 12.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain Torsin PF06309.11 AFZ81646.1 - 0.0018 18.3 0.0 0.0065 16.6 0.0 1.9 1 0 0 1 1 1 1 Torsin AAA_3 PF07726.11 AFZ81646.1 - 0.0028 17.5 0.2 0.53 10.1 0.0 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 AFZ81646.1 - 0.0031 17.4 0.0 0.035 14.0 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_30 PF13604.6 AFZ81646.1 - 0.0039 16.9 0.0 4.1 7.1 0.1 2.8 2 1 0 2 2 2 1 AAA domain AAA_24 PF13479.6 AFZ81646.1 - 0.0062 16.3 0.2 1.1 8.9 0.0 3.1 3 1 0 3 3 2 1 AAA domain Roc PF08477.13 AFZ81646.1 - 0.017 15.3 0.0 5.5 7.2 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 AFZ81646.1 - 0.02 14.8 0.0 8 6.3 0.0 2.8 2 1 0 2 2 2 0 RsgA GTPase DUF1866 PF08952.11 AFZ81646.1 - 0.022 14.6 0.1 0.19 11.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1866) KTI12 PF08433.10 AFZ81646.1 - 0.022 14.2 0.3 0.33 10.4 0.0 3.0 3 0 0 3 3 3 0 Chromatin associated protein KTI12 ABC_tran PF00005.27 AFZ81646.1 - 0.025 15.1 0.4 4.5 7.8 0.0 2.9 2 0 0 2 2 2 0 ABC transporter NTPase_1 PF03266.15 AFZ81646.1 - 0.025 14.5 0.0 5.4 6.9 0.0 3.0 2 0 0 2 2 2 0 NTPase AAA_25 PF13481.6 AFZ81646.1 - 0.033 13.7 0.0 2.7 7.5 0.0 2.9 3 0 0 3 3 3 0 AAA domain DEAD PF00270.29 AFZ81646.1 - 0.037 13.8 0.0 3.9 7.2 0.0 3.5 3 1 0 3 3 3 0 DEAD/DEAH box helicase AAA_29 PF13555.6 AFZ81646.1 - 0.041 13.6 0.1 8.9 6.1 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain Rad17 PF03215.15 AFZ81646.1 - 0.043 13.7 0.0 0.49 10.3 0.0 2.5 2 0 0 2 2 2 0 Rad17 P-loop domain Vps39_1 PF10366.9 AFZ81646.1 - 0.099 12.9 0.2 13 6.1 0.0 3.5 3 0 0 3 3 2 0 Vacuolar sorting protein 39 domain 1 AAA_19 PF13245.6 AFZ81646.1 - 0.12 12.7 4.3 2.3 8.6 1.0 3.8 4 1 0 4 4 2 0 AAA domain PPR PF01535.20 AFZ81647.1 - 1.2e-12 47.2 19.7 4.4e-05 23.4 0.3 8.5 9 0 0 9 9 9 3 PPR repeat PPR_2 PF13041.6 AFZ81647.1 - 2.1e-10 40.6 8.8 0.00015 21.9 0.0 6.6 5 2 2 7 7 7 2 PPR repeat family PPR_long PF17177.4 AFZ81647.1 - 2.7e-06 26.9 10.5 0.0036 16.7 0.1 4.0 2 1 0 3 3 3 2 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 AFZ81647.1 - 0.0095 15.6 0.4 0.13 12.0 0.1 2.6 2 0 0 2 2 2 1 PPR repeat PPR_3 PF13812.6 AFZ81647.1 - 0.012 15.7 3.1 6.7 6.9 0.0 4.4 4 1 1 5 5 5 0 Pentatricopeptide repeat domain FeS_assembly_P PF01883.19 AFZ81648.1 - 5.8e-09 36.0 0.0 9.7e-09 35.3 0.0 1.4 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein PUNUT PF16913.5 AFZ81649.1 - 7.3e-06 25.4 5.3 7.3e-06 25.4 5.3 2.3 2 0 0 2 2 2 2 Purine nucleobase transmembrane transport EamA PF00892.20 AFZ81649.1 - 0.0014 18.8 19.7 0.023 14.8 6.1 2.6 2 1 0 2 2 2 2 EamA-like transporter family DUF5331 PF17265.2 AFZ81649.1 - 0.079 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5331) SET PF00856.28 AFZ81650.1 - 3.1e-17 63.5 0.1 3.1e-17 63.5 0.1 3.6 3 0 0 3 3 3 1 SET domain Bromodomain PF00439.25 AFZ81650.1 - 1.4e-09 37.9 0.3 1.4e-09 37.9 0.3 3.0 3 0 0 3 3 3 1 Bromodomain PHD PF00628.29 AFZ81650.1 - 1.6e-09 37.5 80.0 0.00029 20.7 7.0 8.9 8 0 0 8 8 8 5 PHD-finger zf-HC5HC2H PF13771.6 AFZ81650.1 - 0.00038 20.6 5.3 0.00038 20.6 5.3 7.0 7 0 0 7 7 7 1 PHD-like zinc-binding domain FYRN PF05964.14 AFZ81650.1 - 0.00048 19.9 0.2 0.0028 17.5 0.2 2.4 1 0 0 1 1 1 1 F/Y-rich N-terminus Ubie_methyltran PF01209.18 AFZ81651.1 - 3.4e-79 265.4 0.5 2.2e-78 262.8 0.5 1.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 AFZ81651.1 - 2.6e-18 66.5 0.0 1.5e-16 60.9 0.0 2.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AFZ81651.1 - 2.3e-17 63.4 0.0 1.2e-16 61.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AFZ81651.1 - 1.2e-11 44.6 0.0 2e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AFZ81651.1 - 1.5e-10 41.7 0.0 3e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AFZ81651.1 - 2.7e-10 40.3 0.0 4.1e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_PK PF05891.12 AFZ81651.1 - 0.00019 21.0 0.0 0.0003 20.4 0.0 1.3 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_8 PF05148.15 AFZ81651.1 - 0.00048 20.0 0.0 0.0014 18.5 0.0 1.7 2 0 0 2 2 2 1 Hypothetical methyltransferase DREV PF05219.12 AFZ81651.1 - 0.041 13.0 0.0 0.083 12.0 0.0 1.7 1 1 0 1 1 1 0 DREV methyltransferase UPF0020 PF01170.18 AFZ81651.1 - 0.088 12.5 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 MTS PF05175.14 AFZ81651.1 - 0.092 12.3 0.0 1.7 8.1 0.0 2.3 1 1 1 2 2 2 0 Methyltransferase small domain Peptidase_C78 PF07910.13 AFZ81652.1 - 1.3e-40 139.2 0.4 9.7e-40 136.3 0.3 2.1 2 0 0 2 2 2 1 Peptidase family C78 Peptidase_C54 PF03416.19 AFZ81652.1 - 0.022 14.2 0.0 0.061 12.7 0.0 1.7 1 0 0 1 1 1 0 Peptidase family C54 UPF0020 PF01170.18 AFZ81653.1 - 1.6e-09 37.7 0.0 3.2e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 THUMP PF02926.17 AFZ81653.1 - 0.0058 16.7 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 THUMP domain SyrA PF11089.8 AFZ81653.1 - 0.029 14.4 0.0 0.069 13.2 0.0 1.6 1 0 0 1 1 1 0 Exopolysaccharide production repressor WD40 PF00400.32 AFZ81654.1 - 6e-13 49.1 4.6 0.00045 21.0 0.0 5.5 5 1 0 5 5 5 4 WD domain, G-beta repeat NLE PF08154.12 AFZ81654.1 - 2.7e-10 40.6 0.1 6.4e-10 39.4 0.1 1.7 1 0 0 1 1 1 1 NLE (NUC135) domain ANAPC4_WD40 PF12894.7 AFZ81654.1 - 9.6e-06 25.8 0.0 0.93 9.8 0.0 4.7 2 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain SET PF00856.28 AFZ81655.1 - 5.3e-21 75.7 1.9 5.3e-21 75.7 1.9 3.0 2 2 0 2 2 2 1 SET domain PRP1_N PF06424.12 AFZ81655.1 - 0.0085 16.5 2.2 0.022 15.1 2.2 1.6 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal DNA_pol_B_exo1 PF03104.19 AFZ81656.1 - 6e-51 173.6 0.3 6e-51 173.6 0.3 3.0 3 1 0 3 3 3 1 DNA polymerase family B, exonuclease domain DUF1744 PF08490.12 AFZ81656.1 - 1.4e-17 63.3 0.7 2.7e-17 62.4 0.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B PF00136.21 AFZ81656.1 - 4.5e-10 38.8 6.8 1.1e-07 31.0 0.0 4.2 5 0 0 5 5 5 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 AFZ81656.1 - 2.2e-07 30.8 0.0 1.1e-06 28.5 0.0 2.1 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 AFZ81656.1 - 0.0084 16.1 5.4 0.014 15.4 0.0 4.0 5 1 1 6 6 6 1 RNase_H superfamily RecR PF02132.15 AFZ81656.1 - 0.77 9.4 6.8 0.24 11.0 0.8 2.8 2 1 0 2 2 2 0 RecR protein Gly_acyl_tr_N PF06021.11 AFZ81656.1 - 4.2 7.4 9.2 5.3 7.1 2.4 3.3 3 0 0 3 3 3 0 Aralkyl acyl-CoA:amino acid N-acyltransferase HigB_toxin PF09907.9 AFZ81657.1 - 0.059 13.6 0.0 0.098 12.9 0.0 1.3 1 0 0 1 1 1 0 HigB_toxin, RelE-like toxic component of a toxin-antitoxin system CPW_WPC PF09717.10 AFZ81658.1 - 5.7e-30 104.1 20.5 5.8e-15 56.0 11.8 2.5 2 0 0 2 2 2 2 Plasmodium falciparum domain of unknown function (CPW_WPC) Tox-REase-2 PF15646.6 AFZ81658.1 - 0.14 12.3 0.2 0.23 11.7 0.2 1.3 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 2 Rho_Binding PF08912.11 AFZ81658.1 - 0.97 10.3 5.8 0.91 10.4 1.5 2.4 2 0 0 2 2 2 0 Rho Binding Pkinase PF00069.25 AFZ81659.1 - 3.9e-60 203.5 0.0 5.7e-60 202.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ81659.1 - 2.2e-29 102.5 0.0 6e-29 101.1 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 AFZ81659.1 - 1e-05 25.0 0.0 1.5e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 AFZ81659.1 - 0.0032 16.9 0.0 0.0056 16.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 AFZ81659.1 - 0.0039 16.2 0.0 0.0058 15.6 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 AFZ81659.1 - 0.01 15.8 0.3 0.031 14.2 0.2 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 AFZ81659.1 - 0.074 12.6 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase ABC_tran PF00005.27 AFZ81661.1 - 3.2e-30 105.4 0.0 3.4e-16 60.0 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 AFZ81661.1 - 5.2e-06 26.5 0.4 0.23 11.2 0.1 3.3 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 AFZ81661.1 - 1.1e-05 25.9 0.0 0.06 13.7 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 AFZ81661.1 - 6e-05 22.7 0.8 0.2 11.4 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_30 PF13604.6 AFZ81661.1 - 0.00021 21.1 0.0 0.19 11.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain DUF87 PF01935.17 AFZ81661.1 - 0.00043 20.5 2.3 0.051 13.7 0.1 3.3 3 0 0 3 3 3 1 Helicase HerA, central domain RsgA_GTPase PF03193.16 AFZ81661.1 - 0.0011 18.9 1.0 0.097 12.6 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 AFZ81661.1 - 0.0013 19.0 0.0 1.9 8.7 0.0 3.5 3 0 0 3 3 3 1 AAA domain Zeta_toxin PF06414.12 AFZ81661.1 - 0.0019 17.5 0.3 0.82 8.9 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin AAA_18 PF13238.6 AFZ81661.1 - 0.0039 17.7 0.1 3.2 8.3 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 AFZ81661.1 - 0.0055 16.5 1.6 1.5 8.4 0.1 2.6 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 AFZ81661.1 - 0.011 15.8 0.1 0.18 11.9 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase NACHT PF05729.12 AFZ81661.1 - 0.013 15.5 0.4 3 7.8 0.1 2.5 2 0 0 2 2 2 0 NACHT domain SMC_N PF02463.19 AFZ81661.1 - 0.014 14.8 0.6 0.19 11.1 0.0 2.5 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain DnaB_C PF03796.15 AFZ81661.1 - 0.019 14.3 0.0 0.13 11.5 0.0 2.0 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain FtsK_SpoIIIE PF01580.18 AFZ81661.1 - 0.02 14.3 1.2 1.7 7.9 0.1 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family cobW PF02492.19 AFZ81661.1 - 0.025 14.2 0.3 6.8 6.2 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.20 AFZ81661.1 - 0.031 13.3 0.6 6.5 5.7 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein MeaB PF03308.16 AFZ81661.1 - 0.037 13.0 0.9 0.073 12.0 0.1 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP_bind_1 PF03029.17 AFZ81661.1 - 0.046 13.5 0.1 6.5 6.4 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_23 PF13476.6 AFZ81661.1 - 0.056 14.0 9.0 0.84 10.1 1.0 3.3 3 0 0 3 3 3 0 AAA domain NB-ARC PF00931.22 AFZ81661.1 - 0.073 12.2 0.6 1.6 7.9 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain AAA_25 PF13481.6 AFZ81661.1 - 0.091 12.3 0.1 1.6 8.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 AFZ81661.1 - 0.12 12.2 0.3 8.2 6.3 0.1 2.6 2 0 0 2 2 2 0 NTPase TsaE PF02367.17 AFZ81661.1 - 0.13 12.3 0.4 3.1 7.8 0.1 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Dynamin_N PF00350.23 AFZ81661.1 - 0.16 12.1 1.5 8.5 6.4 0.1 2.4 2 0 0 2 2 2 0 Dynamin family DEAD PF00270.29 AFZ81662.1 - 6.1e-46 156.4 0.0 1.1e-45 155.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AFZ81662.1 - 2.8e-22 79.1 0.0 7.5e-22 77.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 AFZ81662.1 - 5e-18 65.1 0.4 1.1e-17 64.0 0.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 AFZ81662.1 - 0.0057 16.7 0.0 0.013 15.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 AFZ81662.1 - 0.17 12.2 0.4 0.65 10.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain OCRE PF17780.1 AFZ81663.1 - 3e-10 39.9 5.9 3e-10 39.9 5.9 2.9 3 0 0 3 3 3 1 OCRE domain zf-RanBP PF00641.18 AFZ81663.1 - 1.2e-05 24.5 1.3 2.7e-05 23.4 1.3 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Vps36-NZF-N PF16988.5 AFZ81663.1 - 0.0014 17.9 1.1 0.015 14.7 1.1 2.6 1 1 0 1 1 1 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain Tfb4 PF03850.14 AFZ81664.1 - 2.5e-19 69.9 0.0 4.6e-19 69.0 0.0 1.4 1 1 0 1 1 1 1 Transcription factor Tfb4 ER_lumen_recept PF00810.18 AFZ81665.1 - 4.7e-49 167.0 13.0 7.9e-49 166.3 13.0 1.4 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.14 AFZ81665.1 - 0.022 14.5 0.4 0.022 14.5 0.4 4.7 3 2 2 5 5 5 0 PQ loop repeat CAML PF14963.6 AFZ81665.1 - 4.4 7.4 5.1 7.1 6.7 5.1 1.2 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand HCNGP PF07818.13 AFZ81666.1 - 0.033 14.8 0.4 0.14 12.8 0.4 2.1 1 0 0 1 1 1 0 HCNGP-like protein Romo1 PF10247.9 AFZ81667.1 - 8e-07 29.3 0.6 1.4e-06 28.6 0.6 1.4 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 PRIMA1 PF16101.5 AFZ81667.1 - 0.1 12.6 1.0 0.17 12.0 1.0 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Proteasome PF00227.26 AFZ81668.1 - 2.1e-56 190.4 0.0 2.6e-56 190.1 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AFZ81668.1 - 1.9e-13 49.8 0.2 3.5e-13 49.0 0.2 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Ssl1 PF04056.14 AFZ81668.1 - 0.013 15.3 0.9 0.31 10.8 0.0 2.1 2 0 0 2 2 2 0 Ssl1-like Proteasome PF00227.26 AFZ81669.1 - 2.8e-57 193.3 0.3 3.5e-57 193.0 0.3 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AFZ81669.1 - 3.8e-14 52.0 0.0 8.2e-14 51.0 0.0 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature EccE PF11203.8 AFZ81669.1 - 0.0056 17.0 0.1 0.031 14.6 0.1 2.0 2 0 0 2 2 2 1 Putative type VII ESX secretion system translocon, EccE zf-C3HC4_2 PF13923.6 AFZ81670.1 - 1.9e-05 24.4 15.1 3.4e-05 23.6 15.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AFZ81670.1 - 0.00016 21.5 17.0 0.0003 20.6 17.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AFZ81670.1 - 0.0013 18.5 16.5 0.002 17.9 16.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AFZ81670.1 - 0.002 18.4 16.8 0.0033 17.7 16.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_6 PF14835.6 AFZ81670.1 - 0.0086 15.9 10.8 0.017 15.0 10.8 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.6 AFZ81670.1 - 0.049 13.6 16.6 0.087 12.8 16.6 1.4 1 0 0 1 1 1 0 zinc-RING finger domain MyTH4 PF00784.17 AFZ81670.1 - 0.13 12.8 0.8 2.2 8.8 0.0 2.7 2 1 1 3 3 3 0 MyTH4 domain zf-C3HC4_5 PF17121.5 AFZ81670.1 - 0.4 10.6 8.6 1.1 9.2 8.6 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AFZ81670.1 - 7.8 6.6 14.5 18 5.5 14.5 1.6 1 0 0 1 1 1 0 RING-type zinc-finger FtsJ PF01728.19 AFZ81672.1 - 4.4e-57 193.0 0.6 3.6e-56 190.0 0.2 2.4 2 0 0 2 2 2 1 FtsJ-like methyltransferase Spb1_C PF07780.12 AFZ81672.1 - 1.4e-42 145.7 19.2 1.4e-42 145.7 19.2 2.6 3 0 0 3 3 3 1 Spb1 C-terminal domain DUF3381 PF11861.8 AFZ81672.1 - 1.2e-27 96.7 5.7 1.2e-27 96.7 5.7 4.5 2 1 1 4 4 4 1 Domain of unknown function (DUF3381) ATP-synt_C PF00137.21 AFZ81673.1 - 3.5e-28 97.7 26.5 6e-14 52.1 10.0 2.1 2 0 0 2 2 2 2 ATP synthase subunit C DNA_Packaging_2 PF11123.8 AFZ81674.1 - 0.018 15.3 1.5 0.082 13.1 0.1 2.4 2 0 0 2 2 2 0 DNA packaging protein Peptidase_S46 PF10459.9 AFZ81674.1 - 0.039 12.6 2.1 0.051 12.2 2.1 1.3 1 1 0 1 1 1 0 Peptidase S46 Hormone_1 PF00103.20 AFZ81674.1 - 0.047 13.4 1.7 0.096 12.4 1.7 1.5 1 0 0 1 1 1 0 Somatotropin hormone family Syntaxin_2 PF14523.6 AFZ81674.1 - 0.2 12.1 13.2 0.072 13.5 7.7 2.1 2 0 0 2 2 2 0 Syntaxin-like protein Sec20 PF03908.13 AFZ81674.1 - 0.63 10.0 6.9 0.1 12.5 0.6 2.3 2 1 0 2 2 2 0 Sec20 HRDC PF00570.23 AFZ81676.1 - 0.052 13.5 0.0 0.26 11.3 0.0 2.0 2 0 0 2 2 2 0 HRDC domain KH_1 PF00013.29 AFZ81676.1 - 0.073 12.9 0.0 0.23 11.3 0.0 1.9 1 0 0 1 1 1 0 KH domain S10_plectin PF03501.15 AFZ81677.1 - 8.5e-41 137.9 0.1 1e-40 137.7 0.1 1.0 1 0 0 1 1 1 1 Plectin/S10 domain Methyltransf_10 PF05971.12 AFZ81678.1 - 2e-53 181.7 0.8 1.6e-41 142.6 0.0 3.5 3 1 0 3 3 3 3 RNA methyltransferase Methyltransf_31 PF13847.6 AFZ81678.1 - 0.0003 20.6 0.2 0.0025 17.6 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain MTS PF05175.14 AFZ81678.1 - 0.00033 20.3 0.0 0.00065 19.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 AFZ81678.1 - 0.00066 19.2 0.0 0.0012 18.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 AFZ81678.1 - 0.0015 19.2 0.0 0.041 14.6 0.0 2.9 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_18 PF12847.7 AFZ81678.1 - 0.0031 17.4 0.0 0.0065 16.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AFZ81678.1 - 0.029 15.0 0.0 0.45 11.2 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase domain RRM_1 PF00076.22 AFZ81679.1 - 8.6e-22 76.8 2.2 4.5e-21 74.5 0.1 2.9 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 AFZ81679.1 - 0.00066 19.3 0.0 0.0015 18.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AFZ81679.1 - 0.01 15.9 0.3 0.33 11.1 0.0 2.9 2 2 0 2 2 2 0 RNA recognition motif TaqI_C PF12950.7 AFZ81679.1 - 0.011 15.7 1.9 0.013 15.5 0.2 1.9 2 0 0 2 2 2 0 TaqI-like C-terminal specificity domain GFP PF01353.22 AFZ81680.1 - 0.0016 18.0 1.2 0.0019 17.7 0.2 1.6 2 0 0 2 2 2 1 Green fluorescent protein HrpB7 PF09486.10 AFZ81680.1 - 0.051 14.0 0.7 2.6 8.4 0.1 2.7 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) BLOC1_2 PF10046.9 AFZ81680.1 - 0.35 11.2 21.3 0.37 11.1 2.5 3.8 2 2 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fur_reg_FbpB PF13040.6 AFZ81680.1 - 5.2 6.7 13.6 0.051 13.1 3.7 2.8 3 0 0 3 3 3 0 Fur-regulated basic protein B PHM7_cyt PF14703.6 AFZ81680.1 - 5.3 7.2 9.9 10 6.3 7.4 2.7 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter DUF2524 PF10732.9 AFZ81681.1 - 0.078 13.3 4.8 0.1 12.9 0.7 2.8 1 1 1 3 3 3 0 Protein of unknown function (DUF2524) Lys_export PF03956.13 AFZ81681.1 - 0.13 11.8 0.1 0.17 11.4 0.1 1.1 1 0 0 1 1 1 0 Lysine exporter LysO FUN14 PF04930.15 AFZ81681.1 - 1.8 9.0 5.1 2.2 8.8 0.5 2.4 2 1 0 2 2 2 0 FUN14 family TFIIE-A_C PF11521.8 AFZ81682.1 - 0.011 16.0 2.4 0.021 15.1 2.4 1.4 1 1 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha RsfS PF02410.15 AFZ81683.1 - 1.6e-12 47.7 0.0 3.1e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation DUF1450 PF07293.11 AFZ81683.1 - 0.084 12.7 0.0 1.5 8.7 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1450) Glyco_hydro38C2 PF17677.1 AFZ81683.1 - 0.13 12.4 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Ribosomal_S7e PF01251.18 AFZ81684.1 - 3.1e-66 222.6 7.1 3.7e-66 222.4 7.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e DUF695 PF05117.12 AFZ81684.1 - 0.014 15.6 0.0 0.023 14.9 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF695) FCH PF00611.23 AFZ81685.1 - 0.014 15.7 0.1 0.038 14.3 0.1 1.8 1 0 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain DUF1878 PF08963.10 AFZ81685.1 - 0.078 13.5 0.1 0.2 12.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1878) DnaJ PF00226.31 AFZ81686.1 - 0.00062 19.8 0.8 0.0013 18.8 0.0 1.9 2 0 0 2 2 2 1 DnaJ domain NINJA_B PF16136.5 AFZ81686.1 - 0.96 9.8 4.1 1.5 9.3 1.9 2.3 2 1 0 2 2 2 0 Putative nuclear localisation signal RIO1 PF01163.22 AFZ81687.1 - 8.3e-44 149.4 0.1 8.3e-44 149.4 0.1 1.5 2 0 0 2 2 2 1 RIO1 family Rio2_N PF09202.11 AFZ81687.1 - 8e-30 102.9 2.6 1.1e-29 102.5 0.1 2.4 3 0 0 3 3 3 1 Rio2, N-terminal APH PF01636.23 AFZ81687.1 - 5.5e-07 29.8 1.5 0.00031 20.7 0.7 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 AFZ81687.1 - 0.002 17.5 0.2 1.4 8.3 0.1 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family PNRC PF15365.6 AFZ81688.1 - 0.022 14.6 2.0 0.061 13.1 2.0 1.8 1 0 0 1 1 1 0 Proline-rich nuclear receptor coactivator motif Type2_restr_D3 PF16902.5 AFZ81688.1 - 0.085 12.8 0.1 0.18 11.8 0.1 1.5 1 0 0 1 1 1 0 Type-2 restriction enzyme D3 domain UPF0160 PF03690.13 AFZ81689.1 - 2.3e-85 287.1 0.2 2.8e-85 286.7 0.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) DUF1793 PF08760.11 AFZ81689.1 - 0.11 13.0 0.0 1.7 9.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1793) SmpA_OmlA PF04355.13 AFZ81689.1 - 0.43 10.4 2.9 0.36 10.6 0.3 2.0 2 0 0 2 2 2 0 SmpA / OmlA family UPF0160 PF03690.13 AFZ81690.1 - 2e-17 63.8 0.0 2.1e-17 63.7 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Rad1 PF02144.16 AFZ81691.1 - 2.5e-09 36.6 1.3 5.6e-05 22.3 0.0 2.1 1 1 1 2 2 2 2 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.13 AFZ81691.1 - 0.033 13.7 6.2 0.014 14.8 3.1 1.8 1 1 0 2 2 2 0 Rad9 Peptidase_M22 PF00814.25 AFZ81692.1 - 1e-55 189.4 0.0 1.2e-49 169.5 0.0 2.6 2 1 0 2 2 2 2 Glycoprotease family Ribosomal_S10 PF00338.22 AFZ81693.1 - 3e-22 78.7 0.7 1.1e-21 76.9 0.1 2.3 4 0 0 4 4 4 1 Ribosomal protein S10p/S20e ABC_tran PF00005.27 AFZ81694.1 - 9e-35 120.2 0.0 6.3e-17 62.4 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 AFZ81694.1 - 2.2e-12 47.4 8.6 0.0048 16.8 0.0 4.2 2 2 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system RLI PF04068.15 AFZ81694.1 - 3.4e-12 46.0 5.4 7.8e-12 44.8 5.4 1.7 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N PF02463.19 AFZ81694.1 - 2e-08 34.0 6.2 0.00063 19.2 0.2 4.0 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain Fer4 PF00037.27 AFZ81694.1 - 7.9e-08 31.8 3.6 7.9e-08 31.8 3.6 2.3 3 0 0 3 3 1 1 4Fe-4S binding domain AAA_22 PF13401.6 AFZ81694.1 - 5.8e-07 29.9 0.0 0.00025 21.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 AFZ81694.1 - 9.7e-07 28.8 0.6 0.014 15.1 0.3 2.8 2 1 0 2 2 2 2 AAA ATPase domain Rad17 PF03215.15 AFZ81694.1 - 4e-06 26.9 0.1 0.049 13.6 0.1 2.6 2 1 0 2 2 2 2 Rad17 P-loop domain AAA_16 PF13191.6 AFZ81694.1 - 1.4e-05 25.5 0.0 0.022 15.1 0.0 2.4 2 1 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 AFZ81694.1 - 1.6e-05 24.6 0.5 0.16 11.7 0.1 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 AFZ81694.1 - 4.8e-05 23.3 0.1 0.38 10.6 0.0 3.0 3 0 0 3 3 3 2 RsgA GTPase Fer4_6 PF12837.7 AFZ81694.1 - 6e-05 23.0 2.5 6e-05 23.0 2.5 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain AAA PF00004.29 AFZ81694.1 - 8.3e-05 23.0 0.0 0.071 13.5 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 AFZ81694.1 - 0.00019 22.0 0.5 0.023 15.2 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 AFZ81694.1 - 0.00022 21.3 0.2 0.23 11.5 0.0 3.3 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) NACHT PF05729.12 AFZ81694.1 - 0.0003 20.8 0.5 0.048 13.6 0.0 2.4 2 0 0 2 2 2 1 NACHT domain Fer4_21 PF14697.6 AFZ81694.1 - 0.00041 20.4 12.7 0.00082 19.5 12.7 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain RNA_helicase PF00910.22 AFZ81694.1 - 0.0018 18.6 0.0 1.1 9.7 0.0 2.8 2 0 0 2 2 2 1 RNA helicase SRP54 PF00448.22 AFZ81694.1 - 0.0021 17.7 3.0 0.099 12.3 0.0 2.7 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain AAA_24 PF13479.6 AFZ81694.1 - 0.0023 17.7 0.6 0.21 11.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain Fer4_2 PF12797.7 AFZ81694.1 - 0.0027 17.7 1.0 0.0027 17.7 1.0 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_10 PF13237.6 AFZ81694.1 - 0.0032 17.6 1.6 0.0032 17.6 1.6 2.3 1 1 1 2 2 2 1 4Fe-4S dicluster domain AAA_30 PF13604.6 AFZ81694.1 - 0.0036 17.0 0.1 0.39 10.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 AFZ81694.1 - 0.0038 17.2 1.6 0.17 11.8 0.0 2.9 3 0 0 3 3 2 1 NTPase TsaE PF02367.17 AFZ81694.1 - 0.0038 17.2 0.1 0.061 13.3 0.0 2.3 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Fer4_7 PF12838.7 AFZ81694.1 - 0.0042 17.6 1.6 0.0042 17.6 1.6 2.4 2 1 2 4 4 3 2 4Fe-4S dicluster domain AAA_18 PF13238.6 AFZ81694.1 - 0.0057 17.2 0.0 1.6 9.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain Fer4_9 PF13187.6 AFZ81694.1 - 0.0064 16.6 13.6 0.013 15.6 13.6 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain VirE PF05272.11 AFZ81694.1 - 0.0071 16.1 0.1 1.3 8.7 0.0 2.4 2 0 0 2 2 2 1 Virulence-associated protein E Thymidylate_kin PF02223.17 AFZ81694.1 - 0.014 15.1 1.0 5.2 6.7 0.0 2.9 3 0 0 3 3 3 0 Thymidylate kinase AAA_33 PF13671.6 AFZ81694.1 - 0.017 15.3 0.2 2.5 8.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 AFZ81694.1 - 0.038 13.5 0.4 0.79 9.2 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region NB-ARC PF00931.22 AFZ81694.1 - 0.042 13.0 0.1 5.6 6.1 0.0 2.6 3 0 0 3 3 3 0 NB-ARC domain AAA_28 PF13521.6 AFZ81694.1 - 0.067 13.4 0.2 5.3 7.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 AFZ81694.1 - 0.074 13.3 0.0 13 6.1 0.0 2.7 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Septin PF00735.18 AFZ81694.1 - 0.076 12.3 0.1 2.1 7.6 0.0 2.8 4 0 0 4 4 3 0 Septin G-alpha PF00503.20 AFZ81694.1 - 0.092 11.9 0.0 1.1 8.4 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit AAA_19 PF13245.6 AFZ81694.1 - 0.11 12.8 0.2 0.86 9.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 AFZ81694.1 - 0.12 12.5 1.8 14 5.8 0.0 2.6 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_14 PF13173.6 AFZ81694.1 - 0.13 12.3 0.1 12 6.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 AFZ81694.1 - 0.18 11.1 0.1 1.5 8.2 0.0 2.3 3 0 0 3 3 2 0 Magnesium chelatase, subunit ChlI MobB PF03205.14 AFZ81694.1 - 0.24 11.3 2.2 1.1 9.2 0.1 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Roc PF08477.13 AFZ81694.1 - 0.39 11.0 1.0 2.3 8.4 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RRP36 PF06102.12 AFZ81695.1 - 2.8e-26 92.4 18.2 4.3e-26 91.8 18.2 1.3 1 0 0 1 1 1 1 rRNA biogenesis protein RRP36 NES_C_h PF18208.1 AFZ81695.1 - 0.014 15.7 8.2 0.015 15.6 5.3 2.2 1 1 1 2 2 2 0 Nicking enzyme C-terminal middle helical domain DUF4412 PF14371.6 AFZ81695.1 - 0.097 12.5 3.0 0.1 12.4 1.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4412) PDGF_N PF04692.13 AFZ81695.1 - 3.6 8.4 10.0 0.11 13.3 1.7 2.7 2 1 1 3 3 3 0 Platelet-derived growth factor, N terminal region RAP PF08373.10 AFZ81697.1 - 3.2e-23 81.6 0.8 5.5e-23 80.8 0.1 1.8 2 0 0 2 2 2 1 RAP domain MTES_1575 PF18741.1 AFZ81697.1 - 0.00065 19.8 0.0 0.0015 18.7 0.0 1.6 1 0 0 1 1 1 1 REase_MTES_1575 Ntox43 PF15537.6 AFZ81697.1 - 0.034 14.2 0.0 0.057 13.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial toxin 43 Remorin_C PF03763.13 AFZ81698.1 - 0.012 15.5 1.5 0.017 15.0 1.5 1.3 1 0 0 1 1 1 0 Remorin, C-terminal region DUF2703 PF10865.8 AFZ81698.1 - 0.26 11.5 2.1 3.2 8.0 0.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2703) DUF4094 PF13334.6 AFZ81698.1 - 0.62 10.5 6.3 0.15 12.5 2.8 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) TMPIT PF07851.13 AFZ81698.1 - 1 8.6 4.5 1.1 8.4 4.1 1.3 1 1 0 1 1 1 0 TMPIT-like protein zf-C4H2 PF10146.9 AFZ81698.1 - 1.6 9.0 8.5 0.51 10.6 4.4 1.9 1 1 1 2 2 2 0 Zinc finger-containing protein FAM76 PF16046.5 AFZ81698.1 - 2.3 7.5 7.2 3 7.1 7.2 1.2 1 0 0 1 1 1 0 FAM76 protein AnfO_nitrog PF09582.10 AFZ81699.1 - 0.0044 16.4 0.7 0.0044 16.4 0.7 1.6 1 1 1 2 2 2 1 Iron only nitrogenase protein AnfO (AnfO_nitrog) PH_3 PF14593.6 AFZ81699.1 - 0.0047 17.0 0.4 0.0084 16.2 0.4 1.5 1 0 0 1 1 1 1 PH domain Synaptonemal_3 PF15191.6 AFZ81699.1 - 0.045 13.5 1.5 0.1 12.4 0.4 2.1 1 1 1 2 2 2 0 Synaptonemal complex central element protein 3 KxDL PF10241.9 AFZ81699.1 - 0.064 13.5 2.6 4.6 7.6 0.2 2.6 2 1 0 2 2 2 0 Uncharacterized conserved protein DUF1451 PF07295.11 AFZ81699.1 - 0.079 13.0 1.2 0.13 12.3 0.7 1.5 1 1 1 2 2 2 0 Zinc-ribbon containing domain DUF1640 PF07798.11 AFZ81699.1 - 0.44 10.6 7.3 0.096 12.7 1.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) Bcr-Abl_Oligo PF09036.10 AFZ81699.1 - 0.51 10.4 2.2 13 5.9 0.1 2.7 3 0 0 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain SRP68 PF16969.5 AFZ81700.1 - 1.9e-29 103.1 5.2 2.4e-27 96.2 5.8 2.5 2 1 0 2 2 2 2 RNA-binding signal recognition particle 68 TPR_2 PF07719.17 AFZ81700.1 - 0.027 14.5 0.4 1.4 9.2 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TraI_2B PF18340.1 AFZ81700.1 - 0.23 11.6 0.9 1.4 9.1 0.2 2.6 2 1 1 3 3 3 0 DNA relaxase TraI 2B/2B-like domain NAC PF01849.18 AFZ81701.1 - 2.9e-21 75.2 0.3 7.8e-21 73.8 0.4 1.7 2 0 0 2 2 2 1 NAC domain PIN_8 PF18476.1 AFZ81703.1 - 0.026 14.4 0.9 0.032 14.1 0.9 1.1 1 0 0 1 1 1 0 PIN like domain Methyltrans_RNA PF04452.14 AFZ81704.1 - 3.6e-44 150.8 0.0 4.5e-44 150.5 0.0 1.0 1 0 0 1 1 1 1 RNA methyltransferase ProQ_C PF17516.2 AFZ81704.1 - 0.046 13.1 0.2 0.089 12.2 0.2 1.5 1 0 0 1 1 1 0 ProQ C-terminal domain FAST_1 PF06743.15 AFZ81705.1 - 3.9e-08 33.1 15.1 0.0025 17.7 0.1 7.6 8 1 1 9 9 9 4 FAST kinase-like protein, subdomain 1 MatP PF06303.12 AFZ81705.1 - 0.033 14.7 3.0 0.61 10.7 1.7 3.0 2 0 0 2 2 2 0 MatP N-terminal domain His_Phos_2 PF00328.22 AFZ81705.1 - 0.15 11.4 1.6 0.15 11.4 0.2 1.7 2 0 0 2 2 2 0 Histidine phosphatase superfamily (branch 2) Ribosomal_S10 PF00338.22 AFZ81706.1 - 0.11 12.7 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S10p/S20e DUF3713 PF12506.8 AFZ81707.1 - 0.063 13.6 0.3 0.13 12.5 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3713) UPF0515 PF15135.6 AFZ81707.1 - 0.075 12.4 0.4 0.15 11.4 0.4 1.5 1 1 0 1 1 1 0 Uncharacterised protein UPF0515 IL22 PF14565.6 AFZ81707.1 - 0.096 13.0 0.9 0.21 11.9 0.5 1.8 1 1 1 2 2 2 0 Interleukin 22 IL-10-related T-cell-derived-inducible factor HEAT PF02985.22 AFZ81708.1 - 9.9e-07 28.5 3.1 0.012 15.8 0.0 6.2 6 0 0 6 6 6 1 HEAT repeat HEAT_2 PF13646.6 AFZ81708.1 - 0.0081 16.5 0.1 0.54 10.7 0.0 3.4 4 0 0 4 4 4 1 HEAT repeats HEAT_EZ PF13513.6 AFZ81708.1 - 0.0097 16.4 0.0 4.1 8.0 0.0 4.5 5 0 0 5 5 5 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 AFZ81708.1 - 0.025 15.2 5.7 0.8 10.3 0.1 4.9 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region HEPN_Swt1 PF18731.1 AFZ81710.1 - 0.00089 19.6 0.0 0.0025 18.2 0.0 1.7 1 0 0 1 1 1 1 Swt1-like HEPN tRNA_synthFbeta PF17759.1 AFZ81711.1 - 6.5e-28 97.6 0.0 1.2e-27 96.8 0.0 1.4 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 AFZ81711.1 - 9.1e-24 83.5 0.1 1.8e-23 82.5 0.1 1.5 1 0 0 1 1 1 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 AFZ81711.1 - 2.1e-19 69.9 0.0 3.8e-19 69.0 0.0 1.4 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 AFZ81711.1 - 5.3e-17 61.9 0.1 1.1e-11 44.9 0.0 3.1 3 0 0 3 3 3 2 tRNA synthetase B5 domain tRNA-synt_2d PF01409.20 AFZ81711.1 - 0.011 15.2 0.0 0.043 13.3 0.0 1.8 1 1 0 1 1 1 0 tRNA synthetases class II core domain (F) AP2 PF00847.20 AFZ81712.1 - 2e-12 47.2 0.4 5.5e-12 45.7 0.4 1.8 1 0 0 1 1 1 1 AP2 domain WSN PF02206.18 AFZ81712.1 - 0.069 13.1 0.9 8.3 6.4 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function LRR_8 PF13855.6 AFZ81713.1 - 1.1e-07 31.5 1.1 9.1e-06 25.4 0.1 3.6 3 1 0 3 3 3 1 Leucine rich repeat LRR_4 PF12799.7 AFZ81713.1 - 0.00038 20.8 1.0 0.00038 20.8 1.0 4.1 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 AFZ81713.1 - 0.00062 19.6 4.3 9.4 6.6 0.0 3.9 3 0 0 3 3 3 3 Leucine Rich repeat LRR_1 PF00560.33 AFZ81713.1 - 0.075 13.6 7.3 13 6.8 0.0 5.3 5 1 0 5 5 5 0 Leucine Rich Repeat PPTA PF01239.22 AFZ81714.1 - 1.3e-18 66.1 22.8 2e-05 24.1 1.1 5.3 5 1 1 6 6 6 4 Protein prenyltransferase alpha subunit repeat Sec7 PF01369.20 AFZ81715.1 - 1.3e-62 210.8 2.1 1.3e-62 210.8 2.1 2.2 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.7 AFZ81715.1 - 2.8e-17 63.1 3.3 2.8e-17 63.1 3.3 4.2 3 1 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal EF_TS PF00889.19 AFZ81716.1 - 1.1e-10 41.5 0.0 2.1e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Elongation factor TS UBA_4 PF14555.6 AFZ81716.1 - 0.0021 17.9 0.0 0.0038 17.0 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain DNA_PPF PF02916.15 AFZ81716.1 - 0.057 13.8 2.4 0.12 12.8 0.3 2.6 3 1 0 3 3 3 0 DNA polymerase processivity factor Peptidase_C48 PF02902.19 AFZ81717.1 - 1.2e-20 74.3 5.9 1.2e-20 74.3 5.9 2.4 3 0 0 3 3 3 1 Ulp1 protease family, C-terminal catalytic domain PMI_typeI PF01238.21 AFZ81718.1 - 1.2e-48 166.2 0.0 1.1e-47 163.1 0.0 2.1 1 1 0 1 1 1 1 Phosphomannose isomerase type I Pkinase PF00069.25 AFZ81719.1 - 2.7e-39 135.1 0.0 4.3e-34 118.1 0.0 2.4 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AFZ81719.1 - 3.2e-11 43.0 0.0 5.8e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Gpi1 PF05024.15 AFZ81720.1 - 1.3e-25 90.6 19.1 1.3e-25 90.6 19.1 2.0 2 0 0 2 2 2 1 N-acetylglucosaminyl transferase component (Gpi1) Rep_1 PF01446.17 AFZ81720.1 - 0.0042 16.6 0.0 0.0069 15.9 0.0 1.3 1 0 0 1 1 1 1 Replication protein Amidohydro_2 PF04909.14 AFZ81721.1 - 0.0032 17.3 0.0 0.0046 16.8 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase ELFV_dehydrog PF00208.21 AFZ81722.1 - 2.7e-41 141.9 0.0 5e-41 141.0 0.0 1.5 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 AFZ81722.1 - 3.2e-19 68.1 0.0 1.3e-13 49.5 0.0 2.1 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 AFZ81722.1 - 0.0042 17.0 0.0 0.013 15.4 0.0 1.8 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain PgaPase_1 PF06162.12 AFZ81722.1 - 0.067 12.9 0.0 1.6 8.5 0.0 2.9 3 0 0 3 3 3 0 Putative pyroglutamyl peptidase PgaPase_1 SNF2_N PF00176.23 AFZ81725.1 - 4.4e-24 84.9 0.0 9.2e-24 83.8 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AFZ81725.1 - 1.9e-11 44.3 0.0 1.1e-10 41.8 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AFZ81725.1 - 4.1e-06 26.9 0.1 0.00014 21.9 0.0 3.0 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 AFZ81725.1 - 0.067 13.2 0.0 5.7 6.9 0.0 2.4 2 0 0 2 2 2 0 Flavivirus DEAD domain RGM_N PF06535.12 AFZ81725.1 - 0.13 12.4 1.3 0.2 11.9 0.2 1.8 2 0 0 2 2 2 0 Repulsive guidance molecule (RGM) N-terminus S1 PF00575.23 AFZ81726.1 - 6e-15 55.4 0.5 5.1e-06 26.7 0.0 3.0 3 0 0 3 3 3 2 S1 RNA binding domain Lipoprotein_9 PF03180.14 AFZ81726.1 - 0.017 14.2 0.3 0.036 13.2 0.3 1.5 1 0 0 1 1 1 0 NLPA lipoprotein QH-AmDH_gamma PF08992.11 AFZ81726.1 - 0.15 12.1 0.0 0.73 9.9 0.0 2.1 2 0 0 2 2 2 0 Quinohemoprotein amine dehydrogenase, gamma subunit DUF2718 PF10918.8 AFZ81726.1 - 0.32 11.5 0.0 0.32 11.5 0.0 2.8 3 1 1 4 4 4 0 Protein of unknown function (DUF2718) Fasciclin PF02469.22 AFZ81727.1 - 6.7e-10 39.3 0.0 8.8e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 Fasciclin domain Ribosomal_L7Ae PF01248.26 AFZ81728.1 - 3.7e-26 90.7 0.1 5.4e-26 90.2 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family T3SSipB PF16535.5 AFZ81728.1 - 0.0017 18.9 0.3 0.0021 18.5 0.3 1.1 1 0 0 1 1 1 1 Type III cell invasion protein SipB PELOTA_1 PF15608.6 AFZ81728.1 - 0.0052 16.6 0.0 0.0076 16.1 0.0 1.2 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 AFZ81728.1 - 0.013 15.5 0.0 0.013 15.5 0.0 1.1 1 0 0 1 1 1 0 RNase P subunit Pop3 Adenosine_kin PF04008.14 AFZ81728.1 - 0.074 12.8 0.0 0.097 12.4 0.0 1.2 1 0 0 1 1 1 0 Adenosine specific kinase S-AdoMet_synt_C PF02773.16 AFZ81729.1 - 3.5e-58 195.5 0.0 7.2e-58 194.5 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 AFZ81729.1 - 5.8e-45 152.4 0.0 1.9e-44 150.8 0.0 1.9 2 1 0 2 2 2 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 AFZ81729.1 - 1.8e-42 144.0 1.6 3.7e-42 143.0 1.6 1.6 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 AFZ81729.1 - 0.15 10.8 1.6 0.59 8.9 0.2 2.0 1 1 0 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) Amidase PF01425.21 AFZ81730.1 - 2e-73 247.9 0.0 3.6e-73 247.1 0.0 1.4 1 1 0 1 1 1 1 Amidase Gemin6 PF06372.12 AFZ81730.1 - 0.017 14.6 1.9 9.6 5.7 0.0 3.5 3 1 1 4 4 4 0 Gemin6 protein zf-C3HC4 PF00097.25 AFZ81731.1 - 4.6e-12 45.6 7.7 7.1e-12 45.0 7.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AFZ81731.1 - 1.2e-11 44.2 7.4 1.9e-11 43.6 7.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AFZ81731.1 - 4.6e-11 42.4 5.5 7.3e-11 41.8 5.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AFZ81731.1 - 6.7e-10 38.8 6.5 1.1e-09 38.1 6.5 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 AFZ81731.1 - 7e-10 39.1 9.5 1.1e-09 38.5 9.5 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 AFZ81731.1 - 1.7e-09 37.5 5.7 1.9e-09 37.4 2.0 2.3 1 1 1 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 AFZ81731.1 - 1.6e-08 34.2 6.6 2.6e-08 33.6 6.6 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 AFZ81731.1 - 7.2e-07 29.3 7.1 1.3e-06 28.4 7.1 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 AFZ81731.1 - 5.5e-06 26.6 6.9 1.4e-05 25.3 6.9 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain Rtf2 PF04641.12 AFZ81731.1 - 3.2e-05 23.4 0.3 4.3e-05 23.0 0.3 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.8 AFZ81731.1 - 5.2e-05 23.0 3.4 8.3e-05 22.3 3.4 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 AFZ81731.1 - 0.002 17.9 2.7 0.0033 17.3 2.7 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 AFZ81731.1 - 0.015 15.3 5.2 0.036 14.1 5.1 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 AFZ81731.1 - 0.03 14.1 8.0 0.051 13.3 3.4 2.7 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_4 PF14570.6 AFZ81731.1 - 0.14 12.0 8.2 0.56 10.0 8.2 1.9 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-UDP PF14569.6 AFZ81731.1 - 0.15 12.2 2.7 0.54 10.4 2.7 1.9 1 1 0 1 1 1 0 Zinc-binding RING-finger Zn_ribbon_17 PF17120.5 AFZ81731.1 - 0.17 11.6 4.9 0.27 10.9 4.9 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-P11 PF03854.14 AFZ81731.1 - 0.22 11.2 6.6 0.4 10.4 6.6 1.4 1 0 0 1 1 1 0 P-11 zinc finger IBR PF01485.21 AFZ81731.1 - 0.92 9.8 9.3 1.7 8.9 7.6 2.2 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain EF-hand_7 PF13499.6 AFZ81732.1 - 3.7e-06 27.3 2.2 3.7e-06 27.3 2.2 2.1 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 AFZ81732.1 - 0.00055 19.7 5.5 0.0033 17.2 0.0 2.9 3 0 0 3 3 3 1 EF-hand domain MgtE_N PF03448.17 AFZ81732.1 - 0.039 14.5 0.1 0.061 13.9 0.1 1.4 1 0 0 1 1 1 0 MgtE intracellular N domain EF-hand_1 PF00036.32 AFZ81732.1 - 0.043 13.4 0.1 0.22 11.1 0.0 2.3 2 0 0 2 2 2 0 EF hand Vps39_1 PF10366.9 AFZ81732.1 - 0.045 14.0 0.0 0.057 13.7 0.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 1 EF-hand_like PF09279.11 AFZ81732.1 - 0.098 13.2 0.2 0.76 10.3 0.0 2.2 2 0 0 2 2 2 0 Phosphoinositide-specific phospholipase C, efhand-like Presenilin PF01080.17 AFZ81733.1 - 0.3 9.8 9.2 0.4 9.4 9.2 1.2 1 0 0 1 1 1 0 Presenilin PPDK_N PF01326.19 AFZ81734.1 - 0.021 14.1 0.1 0.037 13.3 0.1 1.3 1 0 0 1 1 1 0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain STATa_Ig PF18214.1 AFZ81734.1 - 3.7 7.6 6.3 0.34 10.9 1.4 1.8 2 0 0 2 2 2 0 STATa Immunoglobulin-like domain AAA PF00004.29 AFZ81735.1 - 1.1e-15 58.2 0.0 2.9e-15 56.9 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 AFZ81735.1 - 0.001 18.3 0.0 0.0019 17.5 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain ResIII PF04851.15 AFZ81735.1 - 0.0038 17.2 0.0 0.0073 16.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_23 PF13476.6 AFZ81735.1 - 0.0088 16.6 0.1 0.023 15.2 0.1 1.7 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 AFZ81735.1 - 0.02 14.6 0.0 0.039 13.7 0.0 1.5 1 0 0 1 1 1 0 Cytidylate kinase AAA_29 PF13555.6 AFZ81735.1 - 0.032 14.0 0.0 0.086 12.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 AFZ81735.1 - 0.04 14.1 0.0 0.07 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 AFZ81735.1 - 0.062 13.2 2.2 0.15 11.9 0.2 2.5 3 0 0 3 3 3 0 NACHT domain PhoH PF02562.16 AFZ81735.1 - 0.089 12.2 0.1 0.66 9.4 0.0 2.1 2 0 0 2 2 2 0 PhoH-like protein IstB_IS21 PF01695.17 AFZ81735.1 - 0.1 12.3 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_16 PF13191.6 AFZ81735.1 - 0.12 12.8 0.0 0.27 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain RuvB_N PF05496.12 AFZ81735.1 - 0.15 11.8 0.0 0.34 10.6 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 AFZ81735.1 - 0.15 12.4 0.6 6.2 7.3 0.0 2.9 3 0 0 3 3 3 0 RNA helicase AAA_18 PF13238.6 AFZ81735.1 - 0.19 12.3 0.4 2.9 8.5 0.0 3.0 3 0 0 3 3 3 0 AAA domain CRAL_TRIO PF00650.20 AFZ81736.1 - 2.2e-26 92.5 1.5 2.2e-26 92.5 1.5 2.0 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 AFZ81736.1 - 1.7e-05 25.0 0.5 4.1e-05 23.7 0.5 1.6 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Yip1 PF04893.17 AFZ81737.1 - 0.17 11.6 9.7 0.46 10.2 9.7 1.7 1 1 0 1 1 1 0 Yip1 domain DUF3399 PF11879.8 AFZ81738.1 - 0.11 12.9 0.1 0.72 10.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3399) LSM PF01423.22 AFZ81739.1 - 0.0002 21.0 1.9 0.00064 19.4 1.2 2.2 2 1 0 2 2 2 1 LSM domain WD40 PF00400.32 AFZ81740.1 - 6.3e-08 33.2 2.4 0.12 13.3 0.1 5.2 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AFZ81740.1 - 2.8e-06 27.6 0.0 0.013 15.7 0.0 3.6 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain GP63 PF17471.2 AFZ81740.1 - 0.1 12.8 0.0 0.29 11.3 0.0 1.7 1 0 0 1 1 1 0 Gene product 63 UQ_con PF00179.26 AFZ81741.1 - 1.2e-44 151.3 0.0 1.5e-44 151.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 AFZ81741.1 - 0.018 14.8 0.0 0.026 14.2 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B RRM_1 PF00076.22 AFZ81742.1 - 1.5e-32 111.2 1.0 7e-15 54.6 0.0 4.4 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Phage_TAC_13 PF16459.5 AFZ81742.1 - 0.011 16.2 0.1 5.9 7.4 0.0 2.5 2 0 0 2 2 2 0 Phage tail assembly chaperone, TAC RRM_occluded PF16842.5 AFZ81742.1 - 0.022 14.6 0.0 2.7 7.9 0.0 2.7 2 0 0 2 2 2 0 Occluded RNA-recognition motif Suf PF05843.14 AFZ81742.1 - 0.025 14.6 2.6 6.3 6.7 0.1 3.5 3 1 1 4 4 4 0 Suppressor of forked protein (Suf) RRM_3 PF08777.11 AFZ81742.1 - 0.058 13.4 0.0 2.2 8.4 0.0 2.7 2 0 0 2 2 2 0 RNA binding motif ssDBP PF17878.1 AFZ81742.1 - 0.069 13.4 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 Single-stranded DNA-binding protein Arm PF00514.23 AFZ81743.1 - 5.7e-83 270.7 1.1 4.7e-13 48.7 0.0 8.2 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 AFZ81743.1 - 1.1e-22 80.1 0.0 1.4e-08 35.0 0.0 5.1 3 2 2 5 5 5 4 HEAT-like repeat HEAT_2 PF13646.6 AFZ81743.1 - 2.6e-17 63.0 0.0 1.1e-07 32.2 0.0 4.3 2 1 3 5 5 5 4 HEAT repeats HEAT PF02985.22 AFZ81743.1 - 2.8e-15 55.1 0.1 0.00088 19.3 0.0 7.4 8 0 0 8 8 7 3 HEAT repeat Arm_3 PF16186.5 AFZ81743.1 - 9.5e-11 41.1 0.0 4.3e-10 39.0 0.0 2.1 2 0 0 2 2 2 1 Atypical Arm repeat IBB PF01749.20 AFZ81743.1 - 9.3e-10 38.8 2.0 1.3e-09 38.3 0.6 2.0 2 0 0 2 2 2 1 Importin beta binding domain RICTOR_V PF14668.6 AFZ81743.1 - 1.1e-06 28.8 3.5 0.11 12.7 0.2 5.4 3 1 4 7 7 7 2 Rapamycin-insensitive companion of mTOR, domain 5 Arm_2 PF04826.13 AFZ81743.1 - 1.1e-06 28.4 0.0 0.76 9.2 0.0 4.4 2 1 1 4 4 4 3 Armadillo-like NopRA1 PF16201.5 AFZ81743.1 - 3.7e-06 26.7 0.0 0.0052 16.4 0.0 2.9 2 2 0 2 2 2 2 Nucleolar pre-ribosomal-associated protein 1 V-ATPase_H_C PF11698.8 AFZ81743.1 - 5e-05 23.4 0.0 0.71 10.0 0.0 4.4 4 1 1 5 5 5 1 V-ATPase subunit H DUF3361 PF11841.8 AFZ81743.1 - 0.0013 18.7 0.1 1.3 9.0 0.0 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF3361) HEAT_PBS PF03130.16 AFZ81743.1 - 0.0084 16.7 0.0 1.5 9.7 0.0 3.8 3 0 0 3 3 2 1 PBS lyase HEAT-like repeat NPL PF17800.1 AFZ81744.1 - 1.4e-10 41.6 0.1 1.4e-10 41.6 0.1 1.8 2 0 0 2 2 2 1 Nucleoplasmin-like domain CDC45 PF02724.14 AFZ81744.1 - 0.12 10.7 1.5 0.11 10.8 1.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Nucleoplasmin PF03066.15 AFZ81744.1 - 0.15 12.6 0.0 0.15 12.6 0.0 1.5 2 0 0 2 2 2 0 Nucleoplasmin/nucleophosmin domain DUF2040 PF09745.9 AFZ81745.1 - 9.7e-14 51.5 18.9 1e-11 45.0 18.5 2.4 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 55 (DUF2040) RNA_pol_Rpb5_C PF01191.19 AFZ81746.1 - 5.1e-33 112.8 0.2 9e-33 112.0 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 AFZ81746.1 - 4.9e-23 81.5 0.5 9.6e-23 80.6 0.5 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.12 AFZ81746.1 - 0.00041 20.3 0.0 0.00069 19.6 0.0 1.4 1 0 0 1 1 1 1 Restriction endonuclease Sof1 PF04158.14 AFZ81746.1 - 0.045 14.0 0.2 0.12 12.7 0.2 1.7 1 0 0 1 1 1 0 Sof1-like domain Molybdopterin PF00384.22 AFZ81746.1 - 0.14 11.1 0.1 0.2 10.6 0.1 1.2 1 0 0 1 1 1 0 Molybdopterin oxidoreductase WD40 PF00400.32 AFZ81747.1 - 0.00098 19.9 6.3 0.05 14.5 0.8 3.5 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AFZ81747.1 - 0.0016 18.7 0.0 0.83 10.0 0.0 3.4 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 AFZ81747.1 - 0.022 13.8 0.1 1 8.3 0.1 2.4 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 AFZ81747.1 - 0.11 11.8 4.1 8.4 5.6 0.2 3.2 4 0 0 4 4 4 0 WD40-like domain Rieske PF00355.26 AFZ81748.1 - 7e-13 48.3 0.1 1.6e-12 47.2 0.1 1.6 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 AFZ81748.1 - 0.08 13.4 1.2 0.36 11.3 1.2 2.0 1 1 0 1 1 1 0 Ubiquinol cytochrome reductase transmembrane region FAINT PF04385.15 AFZ81749.1 - 2.4e-13 50.0 0.6 6.6e-06 26.1 0.1 3.4 3 0 0 3 3 3 3 Domain of unknown function, DUF529 PSI_PsaE PF02427.17 AFZ81749.1 - 0.11 12.2 0.1 0.33 10.7 0.1 1.8 1 0 0 1 1 1 0 Photosystem I reaction centre subunit IV / PsaE A_deaminase PF00962.22 AFZ81750.1 - 6.3e-81 272.3 0.0 7.1e-81 272.1 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase KdpA PF03814.15 AFZ81752.1 - 0.17 10.0 0.1 0.21 9.7 0.1 1.1 1 0 0 1 1 1 0 Potassium-transporting ATPase A subunit FAINT PF04385.15 AFZ81753.1 - 1.7e-18 66.4 0.0 1e-05 25.5 0.0 5.1 4 1 1 5 5 5 3 Domain of unknown function, DUF529 Cytochrome_B PF00033.19 EKX71952.1 - 6.4e-50 169.6 23.6 6.4e-50 169.6 23.6 2.4 3 1 0 3 3 3 1 Cytochrome b/b6/petB Cytochrom_B_N_2 PF13631.6 EKX71952.1 - 7.4e-21 74.9 9.8 7.4e-21 74.9 9.8 2.8 3 0 0 3 3 3 1 Cytochrome b(N-terminal)/b6/petB Cytochrom_B_C PF00032.17 EKX71952.1 - 1.1e-18 67.5 2.8 1.1e-18 67.5 2.8 3.0 2 1 0 3 3 3 1 Cytochrome b(C-terminal)/b6/petD COX1 PF00115.20 EKX71953.1 - 4.6e-98 328.9 42.9 5.2e-98 328.7 42.9 1.0 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I GTP_EFTU PF00009.27 EKX71954.1 - 2.6e-54 183.7 2.7 3.7e-54 183.2 2.7 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EKX71954.1 - 5.1e-27 94.4 0.3 2.4e-26 92.2 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EKX71954.1 - 1.2e-16 60.8 3.7 1.2e-15 57.7 1.9 2.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EKX71954.1 - 1.6e-05 24.9 0.3 4.1e-05 23.6 0.3 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKX71954.1 - 0.0084 16.0 0.1 0.0084 16.0 0.1 2.7 2 1 1 3 3 3 1 RsgA GTPase PduV-EutP PF10662.9 EKX71954.1 - 0.072 12.8 3.4 2 8.2 0.4 2.8 2 1 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 EKX71954.1 - 0.088 12.4 0.9 0.28 10.8 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Septin PF00735.18 EKX71954.1 - 0.12 11.6 1.6 0.17 11.1 0.1 1.8 2 0 0 2 2 2 0 Septin Ribosom_S12_S23 PF00164.25 EKX71955.1 - 7.1e-29 99.7 2.5 8.6e-29 99.5 2.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Ribosomal_S12 PF17487.2 EKX71955.1 - 0.033 14.9 0.0 0.05 14.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein S12 Ribosomal_S5 PF00333.20 EKX71956.1 - 2.5e-06 27.4 0.1 3.8e-06 26.8 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain DUF5497 PF17601.2 EKX71956.1 - 0.072 13.4 0.6 0.25 11.7 0.0 2.1 2 1 0 2 2 2 0 Family of unknown function (DUF5497) DUF1850 PF08905.11 EKX71957.1 - 0.082 13.2 0.1 0.24 11.8 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1850) Sec20 PF03908.13 EKX71957.1 - 2.8 7.9 6.4 4 7.4 3.3 2.6 1 1 1 2 2 2 0 Sec20 Ribosomal_L5_C PF00673.21 EKX71958.1 - 3.6e-05 23.9 0.1 6.3e-05 23.1 0.1 1.4 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EKX71958.1 - 0.026 14.8 0.1 0.046 14.1 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein L5 Ribosomal_L2_C PF03947.18 EKX71959.1 - 3.3e-28 98.4 0.0 1e-27 96.8 0.0 1.8 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EKX71959.1 - 0.001 19.0 0.9 0.0072 16.3 0.5 2.4 2 1 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain DUF3330 PF11809.8 EKX71959.1 - 0.095 12.8 0.1 0.22 11.6 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3330) S4 PF01479.25 EKX71960.1 - 2.1e-09 37.0 0.6 3.6e-09 36.2 0.1 1.7 2 0 0 2 2 2 1 S4 domain Ribosomal_S2 PF00318.20 EKX71961.1 - 1.4e-18 66.9 0.0 1.9e-18 66.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S2 CLAMP PF14769.6 EKX71961.1 - 6.2 7.3 9.9 5.2 7.6 0.9 3.2 2 1 1 3 3 3 0 Flagellar C1a complex subunit C1a-32 LSR PF05624.14 EKX71963.1 - 0.61 10.1 2.9 0.91 9.6 2.9 1.2 1 0 0 1 1 1 0 Lipolysis stimulated receptor (LSR) RNA_pol_Rpb2_6 PF00562.28 EKX71964.1 - 9.4e-58 196.1 0.0 1.2e-57 195.7 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 PF04560.20 EKX71964.1 - 3.8e-09 36.8 0.1 1.3e-08 35.1 0.0 1.9 1 1 1 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 EKX71964.1 - 2.6e-06 27.5 0.1 1.1e-05 25.4 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 AAA_2 PF07724.14 EKX71965.1 - 3.7e-15 56.5 0.0 4.9e-15 56.1 0.0 1.1 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EKX71965.1 - 0.00084 19.3 0.0 0.0012 18.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EKX71966.1 - 1.5e-37 129.3 0.0 4e-37 128.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EKX71966.1 - 9.6e-09 35.4 0.0 9.9e-08 32.1 0.0 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EKX71966.1 - 1.3e-07 31.5 0.0 2.2e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA PF00004.29 EKX71966.1 - 1.3e-06 28.9 0.1 6.6e-06 26.6 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EKX71966.1 - 0.00041 19.7 0.0 0.0013 18.1 0.0 1.8 2 0 0 2 2 2 1 Zeta toxin AAA_22 PF13401.6 EKX71966.1 - 0.0045 17.3 0.1 0.028 14.7 0.1 2.3 1 1 0 1 1 1 1 AAA domain Torsin PF06309.11 EKX71966.1 - 0.024 14.7 1.3 0.12 12.4 0.0 2.7 2 1 0 2 2 2 0 Torsin Mg_chelatase PF01078.21 EKX71966.1 - 0.029 13.8 0.0 0.081 12.3 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 EKX71966.1 - 0.048 13.4 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EKX71966.1 - 0.082 13.5 0.2 0.69 10.5 0.0 2.6 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EKX71966.1 - 0.095 13.2 0.1 0.095 13.2 0.1 2.4 2 1 0 2 2 1 0 ABC transporter AAA_33 PF13671.6 EKX71966.1 - 0.14 12.4 0.1 0.4 10.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain FANCI_S2 PF14676.6 EKX71966.1 - 2 8.7 9.2 0.22 11.8 0.1 3.1 3 1 0 3 3 3 0 FANCI solenoid 2 NUC129 PF08157.11 EKX71967.1 - 0.085 13.2 0.1 0.16 12.3 0.1 1.4 1 0 0 1 1 1 0 NUC129 domain DUF4665 PF15679.5 EKX71967.1 - 1.1 9.9 4.6 0.79 10.4 3.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4665) PC4 PF02229.16 EKX71968.1 - 0.026 14.2 0.7 0.34 10.6 0.1 3.1 3 0 0 3 3 3 0 Transcriptional Coactivator p15 (PC4) RIBIOP_C PF04950.12 EKX71969.1 - 3.6e-75 253.1 0.2 3.6e-75 253.1 0.2 1.9 2 0 0 2 2 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EKX71969.1 - 1.5e-24 85.9 0.0 6.4e-24 83.9 0.0 2.2 2 0 0 2 2 2 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.27 EKX71969.1 - 8.5e-06 25.4 2.9 8.2e-05 22.2 0.2 3.4 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain RNA_helicase PF00910.22 EKX71969.1 - 0.00016 22.1 0.1 0.013 15.9 0.0 3.2 3 0 0 3 3 3 1 RNA helicase AAA_16 PF13191.6 EKX71969.1 - 0.00051 20.5 0.0 0.0014 19.0 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EKX71969.1 - 0.00089 19.2 0.0 0.002 18.1 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA PF00004.29 EKX71969.1 - 0.0045 17.4 0.0 0.017 15.6 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EKX71969.1 - 0.0069 16.4 1.5 0.015 15.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EKX71969.1 - 0.0085 16.4 0.0 0.027 14.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EKX71969.1 - 0.011 15.6 2.9 0.054 13.4 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase MMR_HSR1 PF01926.23 EKX71969.1 - 0.023 14.8 0.3 0.079 13.1 0.3 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_7 PF12775.7 EKX71969.1 - 0.027 14.0 0.0 0.088 12.3 0.0 1.8 1 0 0 1 1 1 0 P-loop containing dynein motor region ATPase_2 PF01637.18 EKX71969.1 - 0.034 14.1 0.0 0.034 14.1 0.0 3.2 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea AAA_33 PF13671.6 EKX71969.1 - 0.036 14.2 2.4 0.098 12.8 0.1 2.8 2 1 0 2 2 2 0 AAA domain cobW PF02492.19 EKX71969.1 - 0.063 12.9 0.2 0.17 11.4 0.1 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 EKX71969.1 - 0.068 13.7 1.3 0.31 11.6 0.0 2.6 2 0 0 2 2 2 0 ABC transporter AAA_29 PF13555.6 EKX71969.1 - 0.18 11.6 0.0 0.75 9.6 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_30 PF13604.6 EKX71969.1 - 0.22 11.2 0.7 0.55 9.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EKX71969.1 - 3.9 8.0 9.3 1.2 9.7 0.1 3.4 3 0 0 3 3 3 0 AAA domain FAINT PF04385.15 EKX71970.1 - 1.8e-07 31.1 0.8 3.8e-07 30.1 0.2 1.8 1 1 1 2 2 2 1 Domain of unknown function, DUF529 DUF4141 PF13605.6 EKX71970.1 - 0.14 11.4 0.5 2.4 7.5 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4141) DUF4834 PF16118.5 EKX71971.1 - 0.00033 21.6 1.2 0.0005 21.0 1.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) Zip PF02535.22 EKX71971.1 - 0.0095 15.2 9.8 0.012 14.9 9.8 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter DUF2828 PF11443.8 EKX71971.1 - 0.16 10.0 7.8 0.19 9.8 7.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Ctr PF04145.15 EKX71971.1 - 0.16 12.6 0.3 0.19 12.3 0.3 1.2 1 0 0 1 1 1 0 Ctr copper transporter family Folate_carrier PF01770.18 EKX71971.1 - 0.23 10.2 0.4 0.27 9.9 0.4 1.1 1 0 0 1 1 1 0 Reduced folate carrier SID-1_RNA_chan PF13965.6 EKX71971.1 - 0.27 9.6 0.4 0.33 9.3 0.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Ureide_permease PF07168.11 EKX71971.1 - 0.3 9.8 1.3 0.34 9.6 1.3 1.1 1 0 0 1 1 1 0 Ureide permease MMM1 PF10296.9 EKX71971.1 - 0.39 9.7 2.8 0.44 9.5 2.8 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 Presenilin PF01080.17 EKX71971.1 - 0.42 9.3 5.5 0.45 9.2 5.5 1.1 1 0 0 1 1 1 0 Presenilin V_ATPase_I PF01496.19 EKX71971.1 - 0.51 8.2 6.0 0.52 8.2 6.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 EKX71971.1 - 0.62 9.0 1.3 0.62 9.1 1.3 1.1 1 0 0 1 1 1 0 CLN3 protein FAM76 PF16046.5 EKX71971.1 - 1.1 8.5 14.1 1.3 8.4 14.1 1.1 1 0 0 1 1 1 0 FAM76 protein zf-CW PF07496.15 EKX71972.1 - 3.4e-17 62.2 7.4 6.8e-17 61.2 7.4 1.5 1 0 0 1 1 1 1 CW-type Zinc Finger EF-hand_1 PF00036.32 EKX71973.1 - 2.1e-28 95.7 5.7 6.3e-09 34.8 0.2 4.4 4 1 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 EKX71973.1 - 3.2e-24 85.2 1.4 8.3e-15 55.0 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EKX71973.1 - 7.9e-22 75.3 0.9 4.8e-07 29.2 0.0 4.5 3 1 1 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 EKX71973.1 - 2.1e-18 65.9 4.2 9.2e-09 35.0 0.3 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EKX71973.1 - 1.4e-16 59.1 9.6 1.6e-06 27.3 0.1 4.5 4 1 1 5 5 5 3 EF hand EF-hand_9 PF14658.6 EKX71973.1 - 6.6e-10 39.2 0.0 4.7e-06 26.8 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EKX71973.1 - 0.0019 18.5 0.0 0.37 11.1 0.0 2.2 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EKX71973.1 - 0.002 18.0 1.2 2.5 8.1 0.1 2.7 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 EKX71973.1 - 0.0021 18.2 0.2 2.4 8.4 0.1 2.7 2 1 1 3 3 3 3 Dockerin type I domain EF-hand_11 PF08976.11 EKX71973.1 - 0.0072 17.2 0.0 0.58 11.1 0.0 2.1 1 1 1 2 2 2 1 EF-hand domain UPF0154 PF03672.13 EKX71973.1 - 0.14 12.2 0.0 1.2 9.2 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) IspD PF01128.19 EKX71974.1 - 6.3e-32 111.1 0.0 1e-28 100.6 0.0 2.4 2 0 0 2 2 2 2 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CTP_transf_3 PF02348.19 EKX71974.1 - 0.0013 18.7 0.0 0.1 12.5 0.0 2.2 2 0 0 2 2 2 2 Cytidylyltransferase NTP_transf_3 PF12804.7 EKX71974.1 - 0.031 14.7 0.0 0.074 13.4 0.0 1.6 2 0 0 2 2 2 0 MobA-like NTP transferase domain Ribophorin_I PF04597.14 EKX71975.1 - 1.4e-44 153.0 3.0 1e-43 150.2 3.0 1.9 1 1 0 1 1 1 1 Ribophorin I Asp PF00026.23 EKX71976.1 - 1.8e-66 224.8 0.0 4.6e-66 223.4 0.0 1.6 2 0 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EKX71976.1 - 2.8e-11 44.0 0.0 8e-09 36.0 0.0 2.8 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EKX71976.1 - 0.026 14.3 0.0 0.12 12.2 0.0 2.0 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal FAINT PF04385.15 EKX71979.1 - 0.0035 17.4 5.2 0.018 15.1 0.1 3.6 3 0 0 3 3 3 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX71980.1 - 1.7e-08 34.4 34.7 0.00089 19.3 1.8 7.1 6 1 0 6 6 6 4 Domain of unknown function, DUF529 EpuA PF11772.8 EKX71980.1 - 0.13 12.0 0.0 0.35 10.6 0.0 1.7 1 0 0 1 1 1 0 DNA-directed RNA polymerase subunit beta Hydrolase_3 PF08282.12 EKX71981.1 - 2.3e-40 139.0 0.0 2.7e-40 138.7 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EKX71981.1 - 1.3e-06 28.2 0.0 0.002 17.7 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EKX71981.1 - 0.12 12.7 0.0 0.52 10.6 0.0 2.0 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase FAINT PF04385.15 EKX71982.1 - 6.5e-20 71.0 4.3 1.2e-06 28.5 0.0 4.4 4 0 0 4 4 4 4 Domain of unknown function, DUF529 Hydrolase_4 PF12146.8 EKX71983.1 - 3.4e-20 72.3 0.0 1.4e-19 70.3 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX71983.1 - 3.5e-12 46.2 11.8 0.00078 19.5 0.0 5.6 5 1 0 5 5 5 3 Domain of unknown function, DUF529 Abhydrolase_6 PF12697.7 EKX71983.1 - 0.0012 19.5 0.0 0.0019 18.8 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EKX71983.1 - 0.0019 17.9 0.1 0.025 14.2 0.1 2.5 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EKX71983.1 - 0.06 13.2 0.1 14 5.5 0.0 3.3 4 0 0 4 4 4 0 Phospholipase/Carboxylesterase Abhydrolase_4 PF08386.10 EKX71983.1 - 0.066 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein DUF829 PF05705.14 EKX71983.1 - 0.072 13.0 0.0 0.73 9.7 0.0 2.1 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF829) Ig_C19orf38 PF17737.1 EKX71984.1 - 0.034 14.5 0.0 0.33 11.3 0.0 2.4 2 0 0 2 2 2 0 Ig domain in C19orf38 (HIDE1) dsDNA_bind PF01984.20 EKX71985.1 - 5.1e-20 71.8 10.1 5.7e-20 71.7 10.1 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain DUF4332 PF14229.6 EKX71985.1 - 0.00021 21.5 0.7 0.00037 20.7 0.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4332) Ribosomal_S27e PF01667.17 EKX71987.1 - 8.7e-24 83.0 4.9 1.1e-23 82.7 4.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 TF_Zn_Ribbon PF08271.12 EKX71987.1 - 0.01 15.4 0.4 0.015 14.8 0.4 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding Mei5 PF10376.9 EKX71988.1 - 0.87 9.4 3.6 0.7 9.7 1.4 1.8 2 0 0 2 2 2 0 Double-strand recombination repair protein EMA PF02488.15 EKX71989.1 - 1.8e-27 96.7 0.7 2.1e-27 96.4 0.7 1.0 1 0 0 1 1 1 1 Merozoite Antigen DUF202 PF02656.15 EKX71990.1 - 0.13 12.8 0.0 0.21 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Ribosomal_L24e PF01246.20 EKX71991.1 - 1.5e-25 89.2 1.5 3.4e-25 88.1 1.5 1.6 1 0 0 1 1 1 1 Ribosomal protein L24e DCP2 PF05026.13 EKX71993.1 - 7.4e-21 74.3 0.3 9.5e-20 70.7 0.1 2.2 2 0 0 2 2 2 1 Dcp2, box A domain NUDIX PF00293.28 EKX71993.1 - 1.2e-13 51.3 0.0 2.2e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain CPSase_L_D2 PF02786.17 EKX71994.1 - 4e-89 297.7 0.0 2.6e-65 219.9 0.0 2.6 2 1 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 EKX71994.1 - 1.5e-44 150.9 0.0 3.6e-44 149.7 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 EKX71994.1 - 1.9e-41 141.9 0.0 4.7e-41 140.7 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.19 EKX71994.1 - 1.2e-33 116.1 0.1 3.3e-33 114.6 0.1 1.9 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATPgrasp_Ter PF15632.6 EKX71994.1 - 1.8e-13 50.3 0.0 7.8e-07 28.9 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Peptidase_C26 PF07722.13 EKX71994.1 - 1.5e-09 37.9 0.1 5.5e-08 32.8 0.1 2.4 1 1 0 1 1 1 1 Peptidase C26 ATP-grasp PF02222.22 EKX71994.1 - 6.4e-09 35.6 0.0 5.6e-07 29.3 0.0 2.8 2 1 0 2 2 2 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EKX71994.1 - 8.2e-09 35.3 0.0 2.3e-05 24.0 0.0 2.9 3 0 0 3 3 3 2 D-ala D-ala ligase C-terminus MGS PF02142.22 EKX71994.1 - 9e-06 25.8 0.0 7.9e-05 22.8 0.0 2.7 2 1 0 2 2 2 1 MGS-like domain ATP-grasp_3 PF02655.14 EKX71994.1 - 0.0024 17.9 0.1 0.74 9.8 0.0 2.5 2 0 0 2 2 2 1 ATP-grasp domain DJ-1_PfpI PF01965.24 EKX71994.1 - 0.0028 17.5 0.0 0.27 11.0 0.0 2.8 3 0 0 3 3 3 1 DJ-1/PfpI family Cytochrome_CBB3 PF13442.6 EKX71994.1 - 0.18 12.2 0.1 0.8 10.1 0.0 2.1 2 0 0 2 2 1 0 Cytochrome C oxidase, cbb3-type, subunit III Pkinase PF00069.25 EKX71996.1 - 1.6e-62 211.3 0.0 1.9e-62 211.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKX71996.1 - 3.5e-28 98.6 0.0 5e-28 98.1 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EKX71996.1 - 4.2e-06 26.3 0.1 6.2e-06 25.7 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EKX71996.1 - 8.5e-05 22.0 0.0 0.0011 18.3 0.0 2.3 1 1 2 3 3 3 1 Kinase-like APH PF01636.23 EKX71996.1 - 0.001 19.0 0.1 0.0034 17.3 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EKX71996.1 - 0.033 13.8 0.2 0.051 13.2 0.2 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF1664 PF07889.12 EKX71997.1 - 0.0059 16.7 0.9 0.22 11.6 0.1 3.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) YDG PF18657.1 EKX71997.1 - 0.51 10.6 2.5 1.2 9.3 2.5 1.7 1 0 0 1 1 1 0 YDG domain MMtag PF10159.9 EKX71998.1 - 5.9e-18 64.9 2.2 5.9e-18 64.9 2.2 2.6 2 1 0 3 3 3 1 Multiple myeloma tumor-associated WD40 PF00400.32 EKX71999.1 - 1.9e-07 31.6 2.6 0.00026 21.7 0.0 4.6 3 2 1 4 4 4 2 WD domain, G-beta repeat TFIIIC_delta PF12657.7 EKX71999.1 - 9.3e-05 22.4 0.3 0.0063 16.5 0.0 2.3 2 0 0 2 2 2 2 Transcription factor IIIC subunit delta N-term Abhydrolase_1 PF00561.20 EKX72001.1 - 2.2e-05 24.3 1.0 0.0062 16.2 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EKX72001.1 - 0.081 12.2 0.1 1.1 8.5 0.0 2.3 2 1 1 3 3 3 0 Serine aminopeptidase, S33 DALR_1 PF05746.15 EKX72003.1 - 0.14 12.3 0.0 0.21 11.8 0.0 1.2 1 0 0 1 1 1 0 DALR anticodon binding domain OSTMP1 PF09777.9 EKX72005.1 - 0.19 11.1 1.2 0.42 10.0 1.2 1.5 1 0 0 1 1 1 0 Osteopetrosis-associated transmembrane protein 1 precursor UPF0147 PF03685.13 EKX72005.1 - 0.47 10.5 2.9 0.74 9.9 0.1 3.0 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0147) HIP1_clath_bdg PF16515.5 EKX72005.1 - 2.6 8.7 7.4 0.38 11.4 0.4 3.5 3 0 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 INO80_Ies4 PF08193.11 EKX72006.1 - 0.76 9.7 4.0 1 9.3 4.0 1.2 1 0 0 1 1 1 0 INO80 complex subunit Ies4 Alpha_GJ PF03229.13 EKX72006.1 - 0.82 10.2 2.9 1.4 9.5 2.9 1.4 1 0 0 1 1 1 0 Alphavirus glycoprotein J FleQ PF06490.11 EKX72007.1 - 0.069 13.5 0.1 0.1 13.0 0.1 1.2 1 0 0 1 1 1 0 Flagellar regulatory protein FleQ KH_6 PF15985.5 EKX72008.1 - 2.5e-11 43.7 0.0 3.8e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 KH domain RRM_1 PF00076.22 EKX72009.1 - 7.1e-21 73.8 0.0 3.6e-09 36.3 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EKX72009.1 - 4.9e-07 29.5 0.0 0.011 15.6 0.0 2.4 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_5 PF13893.6 EKX72009.1 - 1.3e-05 24.8 0.0 0.0051 16.4 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2573 PF10835.8 EKX72009.1 - 0.069 13.5 0.1 0.15 12.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2573) FAINT PF04385.15 EKX72010.1 - 3.8e-17 62.1 17.5 0.00034 20.6 0.7 4.6 4 0 0 4 4 4 4 Domain of unknown function, DUF529 RED_N PF07808.13 EKX72011.1 - 4.4e-18 65.7 20.9 7e-17 61.8 16.2 2.9 2 1 0 2 2 2 1 RED-like protein N-terminal region Ntox46 PF15538.6 EKX72011.1 - 0.087 12.8 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial toxin 46 Cep57_MT_bd PF06657.13 EKX72011.1 - 0.11 12.9 5.4 1.3 9.5 0.2 2.8 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 V-ATPase_H_C PF11698.8 EKX72012.1 - 2.8e-41 140.3 1.8 1.9e-40 137.6 0.7 2.4 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_N PF03224.14 EKX72012.1 - 7.5e-38 130.6 5.6 1.2e-37 129.9 5.6 1.2 1 0 0 1 1 1 1 V-ATPase subunit H Arm_2 PF04826.13 EKX72012.1 - 0.0016 18.0 1.3 0.082 12.4 0.0 2.3 2 0 0 2 2 2 2 Armadillo-like RICTOR_V PF14668.6 EKX72012.1 - 0.018 15.3 0.1 0.088 13.1 0.1 2.3 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 Scm3 PF10384.9 EKX72012.1 - 0.025 14.3 0.0 0.072 12.9 0.0 1.8 1 0 0 1 1 1 0 Centromere protein Scm3 AP2 PF00847.20 EKX72013.1 - 1.1e-11 44.7 1.4 3.5e-08 33.6 0.3 2.5 2 0 0 2 2 2 2 AP2 domain DUF5082 PF16888.5 EKX72014.1 - 0.029 14.7 1.6 0.07 13.4 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) DIX PF00778.17 EKX72017.1 - 0.082 12.7 1.5 0.94 9.4 0.1 2.5 2 0 0 2 2 2 0 DIX domain Adeno_E3_CR2 PF02439.15 EKX72018.1 - 0.004 16.9 1.0 0.0083 15.9 1.0 1.5 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 DUF5305 PF17231.2 EKX72018.1 - 0.054 12.9 0.1 0.083 12.3 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) ABC_tran PF00005.27 EKX72019.1 - 5.6e-32 111.1 0.0 2e-17 64.0 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EKX72019.1 - 2.1e-06 27.8 0.1 0.032 14.1 0.0 3.0 3 0 0 3 3 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EKX72019.1 - 1.1e-05 25.0 1.6 0.12 12.2 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EKX72019.1 - 3.4e-05 23.8 0.3 0.036 14.0 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EKX72019.1 - 6.3e-05 23.4 0.0 0.047 14.1 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 EKX72019.1 - 0.00026 20.7 0.1 0.12 12.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EKX72019.1 - 0.00048 20.2 0.1 0.2 11.7 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase Zeta_toxin PF06414.12 EKX72019.1 - 0.0011 18.3 0.2 0.51 9.6 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin AAA_18 PF13238.6 EKX72019.1 - 0.0012 19.4 0.1 2.7 8.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain Dynamin_N PF00350.23 EKX72019.1 - 0.0026 17.8 0.2 0.46 10.5 0.0 2.4 2 0 0 2 2 2 1 Dynamin family DUF87 PF01935.17 EKX72019.1 - 0.0049 17.0 1.9 0.14 12.3 0.1 2.6 2 0 0 2 2 2 1 Helicase HerA, central domain SMC_N PF02463.19 EKX72019.1 - 0.0057 16.1 1.4 0.069 12.6 0.3 2.5 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EKX72019.1 - 0.0057 16.9 0.0 0.9 9.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EKX72019.1 - 0.0071 16.9 5.8 0.66 10.4 1.2 2.7 2 0 0 2 2 2 2 AAA domain FtsK_SpoIIIE PF01580.18 EKX72019.1 - 0.0086 15.5 0.6 1.3 8.3 0.1 2.2 2 0 0 2 2 2 1 FtsK/SpoIIIE family MeaB PF03308.16 EKX72019.1 - 0.014 14.3 0.3 0.13 11.2 0.0 2.1 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DnaB_C PF03796.15 EKX72019.1 - 0.019 14.3 0.0 2.6 7.3 0.0 2.3 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain AAA_15 PF13175.6 EKX72019.1 - 0.038 13.7 1.1 2.9 7.5 0.2 2.3 2 0 0 2 2 2 0 AAA ATPase domain T2SSE PF00437.20 EKX72019.1 - 0.073 12.1 0.4 6.2 5.8 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein NACHT PF05729.12 EKX72019.1 - 0.092 12.7 0.6 17 5.2 0.1 2.5 2 0 0 2 2 2 0 NACHT domain SbcCD_C PF13558.6 EKX72019.1 - 0.1 12.8 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit ATPase_2 PF01637.18 EKX72019.1 - 0.11 12.4 0.3 20 5.0 0.0 3.0 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea cobW PF02492.19 EKX72019.1 - 0.12 11.9 0.3 8.9 5.9 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 EKX72019.1 - 0.17 11.4 0.1 3.3 7.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EKX72019.1 - 0.2 10.8 0.5 1.9 7.6 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain PepSY PF03413.19 EKX72022.1 - 0.01 16.4 0.5 0.033 14.7 0.2 2.0 2 0 0 2 2 2 1 Peptidase propeptide and YPEB domain Mcl1_mid PF12341.8 EKX72023.1 - 3.3e-26 92.3 0.0 1.1e-25 90.6 0.0 1.7 2 0 0 2 2 2 1 Minichromosome loss protein, Mcl1, middle region RAB3GAP2_N PF14655.6 EKX72025.1 - 0.054 12.8 0.1 0.061 12.6 0.1 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus RNA_pol_L_2 PF13656.6 EKX72026.1 - 5.8e-20 70.9 0.0 7.6e-20 70.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain NIF PF03031.18 EKX72028.1 - 4.6e-52 175.9 0.5 6.2e-52 175.5 0.5 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase UQ_con PF00179.26 EKX72029.1 - 6.8e-16 58.2 0.0 7.8e-16 58.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme DnaJ PF00226.31 EKX72030.1 - 1.7e-14 53.7 2.8 1.7e-14 53.7 2.8 2.3 3 0 0 3 3 3 1 DnaJ domain DUF743 PF05332.11 EKX72030.1 - 0.34 11.0 5.3 0.16 12.0 0.4 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF743) Hydrolase_4 PF12146.8 EKX72031.1 - 2e-23 82.9 0.0 1.7e-22 79.9 0.0 2.3 2 1 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX72031.1 - 4.9e-21 74.6 5.2 1.5e-07 31.4 0.1 4.9 4 1 0 4 4 4 3 Domain of unknown function, DUF529 Abhydrolase_1 PF00561.20 EKX72031.1 - 0.0019 17.9 0.1 0.01 15.5 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EKX72031.1 - 0.002 18.0 0.1 0.033 14.0 0.0 2.6 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 EKX72031.1 - 0.0025 18.5 0.0 0.0068 17.0 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EKX72031.1 - 0.013 15.0 0.1 5.3 6.5 0.0 3.0 3 0 0 3 3 3 0 Prolyl oligopeptidase family Ser_hydrolase PF06821.13 EKX72031.1 - 0.035 14.0 0.0 0.89 9.4 0.0 2.2 2 0 0 2 2 2 0 Serine hydrolase BPTA PF17044.5 EKX72031.1 - 0.037 13.9 1.8 0.39 10.5 0.2 2.5 2 0 0 2 2 2 0 Borrelial persistence in ticks protein A FAINT PF04385.15 EKX72032.1 - 2.5e-73 242.2 93.0 8.4e-06 25.8 1.7 20.8 21 0 0 21 21 21 18 Domain of unknown function, DUF529 Viral_P18 PF04521.13 EKX72032.1 - 0.0017 18.2 0.0 0.0048 16.7 0.0 1.7 1 0 0 1 1 1 1 ssRNA positive strand viral 18kD cysteine rich protein Aldo_ket_red PF00248.21 EKX72033.1 - 1.3e-56 192.0 0.0 1.7e-56 191.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family LON_substr_bdg PF02190.16 EKX72034.1 - 8.3e-06 25.8 0.8 9.9e-06 25.6 0.1 1.6 2 0 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain DNA_RNApol_7kD PF03604.13 EKX72035.1 - 1e-16 60.3 3.5 1.5e-16 59.7 3.5 1.3 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit DZR PF12773.7 EKX72035.1 - 0.00093 19.2 0.3 0.0011 18.9 0.3 1.1 1 0 0 1 1 1 1 Double zinc ribbon HypA PF01155.19 EKX72035.1 - 0.0019 18.2 0.2 0.002 18.1 0.2 1.1 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA YhfH PF14149.6 EKX72035.1 - 0.01 15.8 0.3 4.2 7.4 0.0 2.1 2 0 0 2 2 2 0 YhfH-like protein TF_Zn_Ribbon PF08271.12 EKX72035.1 - 0.013 15.0 1.0 3.6 7.2 0.1 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding GFA PF04828.14 EKX72035.1 - 0.013 15.8 0.4 1.7 9.0 0.0 2.1 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme zf-ribbon_3 PF13248.6 EKX72035.1 - 0.014 14.7 2.0 0.054 12.9 2.1 1.8 1 1 0 1 1 1 0 zinc-ribbon domain zf-ISL3 PF14690.6 EKX72035.1 - 0.015 16.0 1.3 0.082 13.6 0.2 2.0 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zinc-ribbon_6 PF10005.9 EKX72035.1 - 0.017 15.8 0.2 0.021 15.5 0.2 1.2 1 0 0 1 1 1 0 zinc-ribbon domain DUF35_N PF12172.8 EKX72035.1 - 0.025 14.4 0.2 0.75 9.7 0.1 2.1 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zf-C2HC5 PF06221.13 EKX72035.1 - 0.026 14.5 0.1 0.031 14.2 0.1 1.1 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type zinc_ribbon_10 PF10058.9 EKX72035.1 - 0.027 14.2 2.7 0.29 10.9 0.1 2.2 1 1 1 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein TFIIS_C PF01096.18 EKX72035.1 - 0.029 14.2 0.2 5.2 7.0 0.1 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) Zn_ribbon_SprT PF17283.2 EKX72035.1 - 0.03 14.2 3.2 0.26 11.2 3.2 2.1 1 1 0 1 1 1 0 SprT-like zinc ribbon domain zf-C4_Topoisom PF01396.19 EKX72035.1 - 0.032 14.0 0.4 4.6 7.1 0.1 2.1 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger Zn-ribbon_8 PF09723.10 EKX72035.1 - 0.035 14.2 1.8 0.078 13.1 1.8 1.6 1 1 0 1 1 1 0 Zinc ribbon domain TackOD1 PF18551.1 EKX72035.1 - 0.038 13.6 0.2 0.041 13.5 0.2 1.1 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 Zn_ribbon_recom PF13408.6 EKX72035.1 - 0.04 14.4 3.5 0.88 10.1 0.5 2.1 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf_UBZ PF18439.1 EKX72035.1 - 0.047 13.3 0.6 2.5 7.7 0.1 2.1 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger A2L_zn_ribbon PF08792.10 EKX72035.1 - 0.075 12.8 2.9 2.1 8.1 0.1 2.2 1 1 1 2 2 2 0 A2L zinc ribbon domain Rubredoxin_2 PF18073.1 EKX72035.1 - 0.11 12.2 4.7 4.3 7.1 0.2 2.2 2 0 0 2 2 2 0 Rubredoxin metal binding domain DUF1451 PF07295.11 EKX72035.1 - 0.12 12.4 0.2 0.14 12.2 0.2 1.1 1 0 0 1 1 1 0 Zinc-ribbon containing domain HECT_2 PF09814.9 EKX72035.1 - 0.14 11.0 0.5 0.16 10.8 0.5 1.3 1 1 0 1 1 1 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding zinc_ribbon_2 PF13240.6 EKX72035.1 - 0.21 11.3 4.5 2.5 7.9 4.5 2.1 1 1 0 1 1 1 0 zinc-ribbon domain UPF0547 PF10571.9 EKX72035.1 - 2.5 8.3 5.8 21 5.3 5.8 2.0 1 1 0 1 1 1 0 Uncharacterised protein family UPF0547 PUB PF09409.10 EKX72036.1 - 2.3e-05 24.2 1.0 4.3e-05 23.4 0.4 1.7 2 0 0 2 2 2 1 PUB domain FIN1 PF17300.2 EKX72036.1 - 1 8.8 5.1 1.7 8.1 5.1 1.3 1 0 0 1 1 1 0 Filaments in between nuclei protein-1 YabA PF06156.13 EKX72036.1 - 3.7 8.2 7.9 2.7 8.7 0.1 3.1 2 1 0 3 3 3 0 Initiation control protein YabA ATP-synt_E PF05680.12 EKX72037.1 - 0.22 11.9 3.3 0.33 11.3 2.7 1.6 1 1 0 1 1 1 0 ATP synthase E chain FAINT PF04385.15 EKX72038.1 - 2.1e-13 50.1 6.6 3.1e-10 40.0 1.8 3.2 3 0 0 3 3 3 2 Domain of unknown function, DUF529 ATE_C PF04377.15 EKX72038.1 - 0.058 14.0 0.0 0.11 13.1 0.0 1.5 1 0 0 1 1 1 0 Arginine-tRNA-protein transferase, C terminus FAINT PF04385.15 EKX72040.1 - 2.7e-09 36.9 3.9 4.7e-09 36.2 3.9 1.3 1 0 0 1 1 1 1 Domain of unknown function, DUF529 U3_assoc_6 PF08640.11 EKX72041.1 - 4.7e-16 58.6 3.1 1.4e-15 57.1 3.1 1.8 1 0 0 1 1 1 1 U3 small nucleolar RNA-associated protein 6 Mad3_BUB1_I PF08311.12 EKX72041.1 - 0.0079 16.2 0.1 0.056 13.4 0.0 2.5 2 0 0 2 2 2 1 Mad3/BUB1 homology region 1 Baculo_gp41 PF04700.12 EKX72041.1 - 0.029 14.1 0.3 0.098 12.4 0.3 1.9 1 0 0 1 1 1 0 Structural glycoprotein p40/gp41 conserved region WBS_methylT PF12589.8 EKX72042.1 - 5.4e-13 49.5 3.1 8.8e-13 48.8 3.1 1.4 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_25 PF13649.6 EKX72042.1 - 2.7e-09 37.6 0.0 5.7e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EKX72042.1 - 6.7e-09 36.3 0.0 1.5e-08 35.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EKX72042.1 - 1.2e-05 25.2 0.2 2e-05 24.5 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EKX72042.1 - 3.3e-05 24.5 0.0 6.8e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EKX72042.1 - 0.00092 19.1 0.0 0.0015 18.4 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EKX72042.1 - 0.0062 16.0 0.1 0.0095 15.4 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) N6_N4_Mtase PF01555.18 EKX72042.1 - 0.0084 15.8 0.1 0.051 13.3 0.0 2.0 2 1 0 2 2 2 1 DNA methylase MetW PF07021.12 EKX72042.1 - 0.011 15.3 0.0 0.054 13.1 0.1 1.9 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW PCMT PF01135.19 EKX72042.1 - 0.011 15.5 0.0 0.016 15.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TPMT PF05724.11 EKX72042.1 - 0.034 13.8 0.0 0.067 12.8 0.0 1.5 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Methyltransf_32 PF13679.6 EKX72042.1 - 0.042 13.8 0.4 0.09 12.8 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 EKX72042.1 - 0.089 12.3 0.1 0.15 11.6 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_4 PF02390.17 EKX72042.1 - 0.11 11.9 0.1 0.21 11.1 0.1 1.4 1 0 0 1 1 1 0 Putative methyltransferase SSURE PF11966.8 EKX72044.1 - 0.059 13.1 0.1 1.4 8.7 0.1 2.7 2 0 0 2 2 2 0 Fibronectin-binding repeat Chromo PF00385.24 EKX72045.1 - 1.4e-18 66.6 2.0 4.3e-13 48.9 0.0 2.4 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow PF01393.19 EKX72045.1 - 4.7e-06 26.6 0.4 0.0082 16.2 0.0 3.5 3 0 0 3 3 3 2 Chromo shadow domain Ribosomal_S10 PF00338.22 EKX72046.1 - 0.00032 20.9 0.2 0.00046 20.4 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e AFG1_ATPase PF03969.16 EKX72047.1 - 3.2e-74 250.0 0.0 6e-71 239.2 0.0 2.1 2 0 0 2 2 2 2 AFG1-like ATPase AAA PF00004.29 EKX72047.1 - 1.1e-06 29.1 0.0 2.8e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Bac_DnaA PF00308.18 EKX72047.1 - 0.0025 17.7 0.1 0.0052 16.6 0.1 1.5 1 0 0 1 1 1 1 Bacterial dnaA protein TniB PF05621.11 EKX72047.1 - 0.021 14.3 1.3 0.91 8.9 0.4 3.0 2 1 0 2 2 2 0 Bacterial TniB protein AAA_14 PF13173.6 EKX72047.1 - 0.026 14.6 0.1 0.064 13.3 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EKX72047.1 - 0.028 14.7 0.3 0.17 12.1 0.3 2.2 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EKX72047.1 - 0.044 13.7 0.2 0.14 12.1 0.2 1.8 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_5 PF07728.14 EKX72047.1 - 0.07 13.1 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) CobA_CobO_BtuR PF02572.15 EKX72047.1 - 0.078 13.2 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP NACHT PF05729.12 EKX72047.1 - 0.11 12.4 0.1 0.69 9.8 0.1 2.1 1 1 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 EKX72047.1 - 0.13 12.6 0.1 0.86 10.0 0.0 2.2 2 0 0 2 2 2 0 RNA helicase Ribosomal_L17 PF01196.19 EKX72048.1 - 1.7e-20 73.7 0.6 2.3e-20 73.3 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein L17 Ribosomal_L27A PF00828.19 EKX72049.1 - 4e-22 79.2 0.0 1e-21 77.9 0.0 1.7 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Sulfotransfer_1 PF00685.27 EKX72049.1 - 0.011 15.2 1.9 0.041 13.4 1.9 1.9 1 1 0 1 1 1 0 Sulfotransferase domain Archease PF01951.16 EKX72050.1 - 1e-37 129.5 0.2 1.4e-37 129.0 0.2 1.2 1 0 0 1 1 1 1 Archease protein family (MTH1598/TM1083) Vac14_Fab1_bd PF12755.7 EKX72051.1 - 0.11 13.1 0.9 68 4.2 0.0 4.0 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region ApoB100_C PF12491.8 EKX72051.1 - 0.12 12.3 0.3 0.55 10.2 0.3 2.1 1 0 0 1 1 1 0 Apolipoprotein B100 C terminal EMA PF02488.15 EKX72053.1 - 2.1e-36 125.9 9.0 2.5e-36 125.6 9.0 1.0 1 0 0 1 1 1 1 Merozoite Antigen FAINT PF04385.15 EKX72053.1 - 0.003 17.6 1.0 0.25 11.4 0.1 3.1 3 0 0 3 3 3 1 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72054.1 - 2.5e-11 43.5 0.4 1e-06 28.7 0.2 3.0 2 1 0 3 3 3 2 Domain of unknown function, DUF529 Fil_haemagg_2 PF13332.6 EKX72055.1 - 0.058 13.5 0.0 0.081 13.0 0.0 1.2 1 0 0 1 1 1 0 Hemagglutinin repeat DUF1910 PF08928.10 EKX72056.1 - 0.073 13.1 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1910) FAINT PF04385.15 EKX72057.1 - 1e-13 51.2 5.8 9.7e-05 22.4 0.4 4.0 3 1 1 4 4 4 3 Domain of unknown function, DUF529 PC4 PF02229.16 EKX72058.1 - 0.34 10.6 0.1 0.34 10.6 0.1 3.4 4 0 0 4 4 4 0 Transcriptional Coactivator p15 (PC4) RRM_1 PF00076.22 EKX72059.1 - 8.2e-11 41.6 0.1 0.0004 20.1 0.1 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NTP_transferase PF00483.23 EKX72060.1 - 1.3e-11 44.6 0.0 4.6e-11 42.8 0.0 1.7 2 0 0 2 2 2 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 EKX72060.1 - 3.4e-08 34.0 0.0 2.2e-07 31.4 0.0 2.0 1 1 0 2 2 2 1 MobA-like NTP transferase domain Hexapep PF00132.24 EKX72060.1 - 2.8e-06 26.8 3.8 0.0001 21.9 0.7 2.9 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 EKX72060.1 - 0.00019 19.7 2.1 0.00034 18.9 2.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Fucokinase PF07959.12 EKX72060.1 - 0.013 14.5 4.5 0.014 14.3 2.2 2.1 2 1 0 2 2 2 0 L-fucokinase KAP PF05804.12 EKX72060.1 - 0.016 13.4 0.1 0.028 12.6 0.1 1.3 1 0 0 1 1 1 0 Kinesin-associated protein (KAP) Pentapeptide_3 PF13576.6 EKX72060.1 - 0.059 13.5 0.4 3.4 7.9 0.0 3.2 3 1 0 4 4 4 0 Pentapeptide repeats (9 copies) Hexapep_2 PF14602.6 EKX72060.1 - 0.55 10.0 3.4 9 6.1 1.2 2.6 1 1 1 2 2 2 0 Hexapeptide repeat of succinyl-transferase FAST_1 PF06743.15 EKX72061.1 - 2.6 8.0 6.6 5.4 7.0 0.4 3.8 3 1 1 4 4 4 0 FAST kinase-like protein, subdomain 1 Glyco_transf_20 PF00982.21 EKX72062.1 - 1.9e-96 323.7 0.0 5.6e-96 322.1 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EKX72062.1 - 7.5e-38 130.0 0.0 3.6e-37 127.7 0.0 2.0 2 0 0 2 2 2 1 Trehalose-phosphatase CBM_20 PF00686.19 EKX72062.1 - 6.3e-13 48.5 0.0 2.2e-12 46.7 0.0 2.0 1 0 0 1 1 1 1 Starch binding domain Hydrolase_3 PF08282.12 EKX72062.1 - 0.0058 16.4 0.1 0.052 13.3 0.0 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DELLA PF12041.8 EKX72062.1 - 0.051 13.5 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 Transcriptional regulator DELLA protein N terminal RabGAP-TBC PF00566.18 EKX72063.1 - 3.9e-54 183.6 0.5 5.1e-54 183.2 0.5 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain ISP3_C PF18045.1 EKX72064.1 - 3.1e-07 30.3 0.2 4.8e-07 29.6 0.2 1.3 1 0 0 1 1 1 1 ISP3 C-terminal ISP1_C PF18161.1 EKX72064.1 - 0.0014 18.6 0.1 0.0022 18.0 0.1 1.3 1 0 0 1 1 1 1 ISP1 C-terminal eIF-1a PF01176.19 EKX72065.1 - 4.5e-08 32.8 0.2 7.1e-08 32.1 0.2 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Sec_GG PF07549.14 EKX72065.1 - 0.074 12.6 0.1 0.14 11.7 0.1 1.5 1 0 0 1 1 1 0 SecD/SecF GG Motif DUF3546 PF12066.8 EKX72066.1 - 7.7e-12 45.4 6.6 1.7e-11 44.3 4.8 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3546) ARS2 PF04959.13 EKX72066.1 - 3.2e-05 24.4 1.4 7.1e-05 23.3 1.1 1.8 1 1 0 1 1 1 1 Arsenite-resistance protein 2 DUF4187 PF13821.6 EKX72066.1 - 0.012 15.4 0.1 0.036 13.8 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4187) zf-met PF12874.7 EKX72066.1 - 0.023 15.1 0.5 0.052 14.0 0.5 1.6 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EKX72066.1 - 0.028 15.3 1.4 0.091 13.6 1.4 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EKX72066.1 - 0.19 12.1 2.2 0.46 10.8 2.2 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EKX72066.1 - 2.3 8.8 6.6 0.17 12.4 1.4 2.0 2 0 0 2 2 2 0 Zinc finger, C2H2 type COG4 PF08318.12 EKX72067.1 - 8.2e-18 64.6 0.4 8.2e-18 64.6 0.4 2.7 2 1 1 3 3 3 1 COG4 transport protein PARP_reg PF02877.14 EKX72067.1 - 0.00043 20.4 0.8 0.0024 18.0 0.2 2.6 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase, regulatory domain Metal_hydrol PF10118.9 EKX72067.1 - 0.033 13.9 0.0 0.07 12.9 0.0 1.5 1 0 0 1 1 1 0 Predicted metal-dependent hydrolase DUF1664 PF07889.12 EKX72068.1 - 0.091 12.8 0.1 0.35 10.9 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) PseudoU_synth_1 PF01416.20 EKX72069.1 - 6.3e-25 87.7 0.0 3.3e-22 79.0 0.0 2.2 2 0 0 2 2 2 2 tRNA pseudouridine synthase DUF2483 PF10656.9 EKX72069.1 - 0.16 12.2 0.4 1.6 9.0 0.1 2.4 2 0 0 2 2 2 0 Hypothetical protein of unknown function (DUF2483) ThiF PF00899.21 EKX72070.1 - 9.3e-17 61.2 0.0 1.2e-16 60.8 0.0 1.1 1 0 0 1 1 1 1 ThiF family EMA PF02488.15 EKX72071.1 - 9.4e-30 104.1 7.1 1.1e-29 103.8 7.1 1.0 1 0 0 1 1 1 1 Merozoite Antigen Nepo_coat PF03391.15 EKX72071.1 - 0.082 12.4 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Nepovirus coat protein, central domain RVT_1 PF00078.27 EKX72073.1 - 4.9e-34 117.8 0.1 8e-34 117.1 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FAINT PF04385.15 EKX72074.1 - 3.6e-08 33.3 0.3 0.0023 18.0 0.0 3.0 2 0 0 2 2 2 2 Domain of unknown function, DUF529 4HB_MCP_1 PF12729.7 EKX72074.1 - 0.32 10.5 4.0 1.4 8.4 1.2 2.2 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction FAINT PF04385.15 EKX72075.1 - 4.9e-44 148.3 11.0 3.7e-08 33.3 0.0 5.6 5 0 0 5 5 5 5 Domain of unknown function, DUF529 ABC_tran PF00005.27 EKX72076.1 - 1e-31 110.3 0.0 1.4e-17 64.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EKX72076.1 - 1.6e-06 28.2 2.2 0.083 12.7 0.1 3.5 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EKX72076.1 - 3.9e-05 23.3 0.8 0.072 12.8 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EKX72076.1 - 8.5e-05 23.0 0.0 0.046 14.1 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain Zeta_toxin PF06414.12 EKX72076.1 - 9.8e-05 21.7 0.3 0.084 12.1 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin AAA_30 PF13604.6 EKX72076.1 - 9.8e-05 22.1 0.1 0.11 12.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EKX72076.1 - 0.00015 21.7 0.8 0.018 15.0 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_18 PF13238.6 EKX72076.1 - 0.00034 21.2 0.2 1.8 9.1 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_23 PF13476.6 EKX72076.1 - 0.001 19.6 3.9 0.27 11.7 0.1 2.4 2 0 0 2 2 2 2 AAA domain DnaB_C PF03796.15 EKX72076.1 - 0.0022 17.4 0.0 0.092 12.1 0.0 2.2 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain MMR_HSR1 PF01926.23 EKX72076.1 - 0.0023 18.0 0.1 0.071 13.2 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase MeaB PF03308.16 EKX72076.1 - 0.0025 16.8 0.4 0.0066 15.5 0.0 1.8 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB T2SSE PF00437.20 EKX72076.1 - 0.0055 15.8 0.9 2.3 7.2 0.1 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein Fer4_NifH PF00142.18 EKX72076.1 - 0.0066 15.9 0.1 3.1 7.2 0.0 2.3 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_22 PF13401.6 EKX72076.1 - 0.0081 16.4 0.1 1.5 9.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EKX72076.1 - 0.0085 15.7 0.5 3.8 7.1 0.0 2.5 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain SMC_N PF02463.19 EKX72076.1 - 0.0099 15.3 0.2 0.25 10.7 0.0 2.4 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain DUF87 PF01935.17 EKX72076.1 - 0.011 15.9 1.8 0.072 13.2 0.1 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain Dynamin_N PF00350.23 EKX72076.1 - 0.012 15.7 0.2 1.3 9.0 0.0 2.5 2 0 0 2 2 2 0 Dynamin family FtsK_SpoIIIE PF01580.18 EKX72076.1 - 0.013 14.8 0.5 3 7.1 0.1 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family NB-ARC PF00931.22 EKX72076.1 - 0.014 14.6 0.3 0.28 10.3 0.0 2.6 2 0 0 2 2 2 0 NB-ARC domain AAA_15 PF13175.6 EKX72076.1 - 0.019 14.7 0.8 5.1 6.7 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain NACHT PF05729.12 EKX72076.1 - 0.023 14.6 0.4 7.3 6.5 0.1 2.6 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.6 EKX72076.1 - 0.033 13.7 0.0 2.3 7.7 0.0 2.8 3 0 0 3 3 3 0 AAA domain SbcCD_C PF13558.6 EKX72076.1 - 0.06 13.6 0.0 0.2 11.9 0.0 1.8 2 0 0 2 2 1 0 Putative exonuclease SbcCD, C subunit TsaE PF02367.17 EKX72076.1 - 0.074 13.1 0.9 6.8 6.7 0.1 2.9 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TrwB_AAD_bind PF10412.9 EKX72076.1 - 0.078 11.9 0.2 7.2 5.4 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain ATPase_2 PF01637.18 EKX72076.1 - 0.084 12.8 0.0 16 5.3 0.0 2.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NTPase_1 PF03266.15 EKX72076.1 - 0.11 12.3 0.3 15 5.5 0.1 2.5 2 0 0 2 2 2 0 NTPase ATP_bind_1 PF03029.17 EKX72076.1 - 0.15 11.9 0.1 17 5.1 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein FAINT PF04385.15 EKX72078.1 - 2e-07 31.0 0.0 0.04 14.0 0.0 3.2 3 0 0 3 3 3 2 Domain of unknown function, DUF529 DUF3721 PF12518.8 EKX72078.1 - 0.012 15.4 0.6 0.021 14.7 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function Frataxin_Cyay PF01491.16 EKX72078.1 - 0.061 13.4 0.0 0.38 10.8 0.0 2.2 2 0 0 2 2 2 0 Frataxin-like domain Choline_kinase PF01633.20 EKX72079.1 - 4.3e-39 134.3 0.0 7.3e-39 133.6 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EKX72079.1 - 2.4e-11 44.0 0.0 3.5e-11 43.5 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EKX72079.1 - 0.0033 16.8 0.2 0.0055 16.1 0.2 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase Thump_like PF18096.1 EKX72079.1 - 0.018 15.0 0.1 0.062 13.2 0.0 1.9 2 0 0 2 2 2 0 THUMP domain-like FAINT PF04385.15 EKX72082.1 - 2e-14 53.4 1.5 1.4e-06 28.3 0.0 3.0 3 0 0 3 3 3 2 Domain of unknown function, DUF529 DUF4224 PF13986.6 EKX72083.1 - 0.12 12.3 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4224) TBP PF00352.21 EKX72085.1 - 1.1e-53 179.2 0.5 1.4e-27 95.5 0.1 2.2 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) MIF4G PF02854.19 EKX72086.1 - 3.4e-21 75.9 0.6 3.4e-21 75.9 0.6 2.0 2 0 0 2 2 2 1 MIF4G domain GlyL_C PF12524.8 EKX72086.1 - 0.18 12.0 1.3 4.1 7.6 0.3 2.8 2 0 0 2 2 2 0 dsDNA virus glycoprotein L C terminal FAINT PF04385.15 EKX72087.1 - 0.0092 16.0 0.3 0.021 14.9 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function, DUF529 PPR_3 PF13812.6 EKX72091.1 - 0.00033 20.7 0.0 0.00059 19.9 0.0 1.4 1 0 0 1 1 1 1 Pentatricopeptide repeat domain PPR_2 PF13041.6 EKX72091.1 - 0.0023 18.1 0.0 0.012 15.8 0.0 2.1 1 1 1 2 2 2 2 PPR repeat family CD99L2 PF12301.8 EKX72093.1 - 0.045 14.1 0.1 0.091 13.1 0.1 1.5 1 0 0 1 1 1 0 CD99 antigen like protein 2 FAINT PF04385.15 EKX72094.1 - 5.6e-17 61.6 0.5 1.6e-09 37.7 0.0 2.7 3 0 0 3 3 3 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72096.1 - 0.033 14.3 0.8 0.14 12.2 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function, DUF529 Glyco_hydro_53 PF07745.13 EKX72098.1 - 0.024 13.6 0.9 0.8 8.6 0.4 2.4 2 0 0 2 2 2 0 Glycosyl hydrolase family 53 Peptidase_C1 PF00112.23 EKX72099.1 - 2.4e-36 125.9 0.9 5.3e-36 124.8 0.1 1.9 2 0 0 2 2 2 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EKX72099.1 - 0.0011 19.3 0.2 0.0022 18.4 0.2 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) RMF PF04957.12 EKX72099.1 - 0.0038 17.4 0.2 8 6.8 0.0 3.8 3 0 0 3 3 3 1 Ribosome modulation factor P-mevalo_kinase PF04275.14 EKX72099.1 - 0.049 13.6 1.2 0.25 11.3 0.2 2.5 3 0 0 3 3 3 0 Phosphomevalonate kinase CDC45 PF02724.14 EKX72099.1 - 0.29 9.4 9.7 0.43 8.8 9.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Neur_chan_memb PF02932.16 EKX72099.1 - 0.83 9.7 2.1 1.4 8.9 2.1 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region LAP1C PF05609.12 EKX72099.1 - 1.4 8.0 13.1 1.8 7.5 13.1 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Zip PF02535.22 EKX72099.1 - 6.8 5.8 5.0 12 5.0 5.0 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter EMA PF02488.15 EKX72101.1 - 0.002 17.8 1.0 0.0028 17.3 0.1 1.6 2 0 0 2 2 2 1 Merozoite Antigen FAINT PF04385.15 EKX72101.1 - 0.0081 16.2 0.4 0.022 14.8 0.4 1.8 1 1 0 1 1 1 1 Domain of unknown function, DUF529 VCBS PF13517.6 EKX72101.1 - 1.9 9.2 10.6 13 6.4 7.0 2.7 2 1 1 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Hydrolase_4 PF12146.8 EKX72102.1 - 3.2e-22 78.9 0.0 1.5e-21 76.8 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX72102.1 - 1.3e-15 57.2 4.0 4.5e-07 29.8 1.0 3.8 3 0 0 3 3 3 3 Domain of unknown function, DUF529 Abhydrolase_6 PF12697.7 EKX72102.1 - 5.7e-05 23.8 0.0 0.00014 22.6 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EKX72102.1 - 0.00026 20.7 0.0 0.00068 19.4 0.0 1.7 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF900 PF05990.12 EKX72102.1 - 0.024 14.2 0.2 0.1 12.1 0.0 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) TOC159_MAD PF11886.8 EKX72102.1 - 0.11 11.4 0.0 0.23 10.3 0.0 1.5 1 0 0 1 1 1 0 Translocase of chloroplast 159/132, membrane anchor domain Abhydrolase_4 PF08386.10 EKX72102.1 - 0.19 11.9 0.0 0.37 10.9 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein Lipocalin PF00061.23 EKX72103.1 - 0.027 14.7 1.0 0.21 11.8 0.1 2.7 2 0 0 2 2 2 0 Lipocalin / cytosolic fatty-acid binding protein family SAVED PF18145.1 EKX72103.1 - 0.12 12.1 0.0 0.31 10.8 0.0 1.6 1 0 0 1 1 1 0 SMODS-associated and fused to various effectors sensor domain Wtap PF17098.5 EKX72104.1 - 2.9e-22 79.3 9.0 2.9e-22 79.3 9.0 2.0 1 1 1 2 2 2 1 WTAP/Mum2p family Shugoshin_N PF07558.11 EKX72104.1 - 9.3e-05 22.2 3.1 9.3e-05 22.2 3.1 2.9 2 1 1 3 3 2 1 Shugoshin N-terminal coiled-coil region Cep57_CLD_2 PF14197.6 EKX72104.1 - 0.0024 17.9 6.3 0.0024 17.9 6.3 3.0 3 0 0 3 3 3 1 Centrosome localisation domain of PPC89 KASH_CCD PF14662.6 EKX72104.1 - 0.0057 16.5 15.1 0.0057 16.5 15.1 2.1 1 1 0 2 2 2 1 Coiled-coil region of CCDC155 or KASH DUF1192 PF06698.11 EKX72104.1 - 0.026 14.6 3.9 2.3 8.3 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) DivIC PF04977.15 EKX72104.1 - 0.038 13.8 1.8 0.038 13.8 1.8 3.7 3 1 1 4 4 4 0 Septum formation initiator DUF4407 PF14362.6 EKX72104.1 - 0.15 11.4 3.5 0.24 10.7 3.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) ZapB PF06005.12 EKX72104.1 - 0.18 12.3 24.7 0.5 10.8 6.1 4.5 2 2 2 4 4 4 0 Cell division protein ZapB DUF4239 PF14023.6 EKX72104.1 - 0.53 10.0 1.9 0.9 9.2 1.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4239) DUF4200 PF13863.6 EKX72104.1 - 1.7 9.1 21.8 0.12 12.7 1.5 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) DUF3450 PF11932.8 EKX72104.1 - 1.8 7.8 10.4 4 6.7 4.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) SlyX PF04102.12 EKX72104.1 - 2.1 9.0 6.1 6.6 7.4 1.2 3.4 2 2 1 3 3 3 0 SlyX JIP_LZII PF16471.5 EKX72104.1 - 2.5 8.4 18.1 2.1 8.5 8.8 3.0 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II Uso1_p115_C PF04871.13 EKX72104.1 - 3.8 7.9 15.3 2.2 8.7 13.1 1.8 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region CENP-H PF05837.12 EKX72104.1 - 4 7.9 18.6 1.1 9.7 10.8 2.9 2 1 1 3 3 3 0 Centromere protein H (CENP-H) Ax_dynein_light PF10211.9 EKX72104.1 - 5.8 6.8 18.1 0.22 11.4 5.4 2.8 1 1 2 3 3 3 0 Axonemal dynein light chain Herpes_BLRF2 PF05812.12 EKX72104.1 - 7.6 6.7 13.6 0.25 11.5 0.9 3.1 1 1 1 2 2 2 0 Herpesvirus BLRF2 protein GIT_CC PF16559.5 EKX72104.1 - 7.8 6.4 12.5 2 8.4 6.2 3.1 2 2 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor API5 PF05918.11 EKX72105.1 - 0.11 11.3 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) FAINT PF04385.15 EKX72107.1 - 2.5e-12 46.7 0.1 8e-05 22.6 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72108.1 - 2.1e-05 24.5 0.0 0.25 11.5 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72110.1 - 7.7e-17 61.1 10.5 1.1e-05 25.4 0.2 4.1 3 2 0 3 3 3 3 Domain of unknown function, DUF529 AAR2 PF05282.11 EKX72110.1 - 0.037 13.4 2.2 0.06 12.7 2.2 1.3 1 0 0 1 1 1 0 AAR2 protein Pfk_N PF18468.1 EKX72110.1 - 0.34 11.3 1.6 2.5 8.6 0.1 2.7 2 1 1 3 3 3 0 Phosphofructokinase N-terminal domain yeast Hydrolase_4 PF12146.8 EKX72111.1 - 2.5e-25 89.1 0.2 1.9e-24 86.2 0.0 2.4 2 1 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX72111.1 - 2.1e-18 66.2 1.2 1.4e-07 31.4 0.1 4.0 3 0 0 3 3 3 3 Domain of unknown function, DUF529 Abhydrolase_1 PF00561.20 EKX72111.1 - 6.8e-07 29.2 1.3 4.2e-06 26.6 1.3 2.3 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 EKX72111.1 - 0.00032 20.6 0.0 0.00096 19.1 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EKX72111.1 - 0.00068 20.3 0.0 0.0014 19.2 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EKX72111.1 - 0.001 18.6 0.7 0.023 14.2 0.1 2.4 1 1 1 2 2 2 1 Prolyl oligopeptidase family DUF900 PF05990.12 EKX72111.1 - 0.037 13.5 0.0 0.086 12.3 0.0 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) PGAP1 PF07819.13 EKX72111.1 - 0.073 12.8 0.1 0.17 11.6 0.1 1.6 1 0 0 1 1 1 0 PGAP1-like protein FAINT PF04385.15 EKX72112.1 - 2.2e-09 37.3 1.0 0.00099 19.1 0.1 2.3 2 0 0 2 2 2 2 Domain of unknown function, DUF529 OSTMP1 PF09777.9 EKX72112.1 - 0.1 12.0 0.0 0.29 10.5 0.0 1.7 2 0 0 2 2 2 0 Osteopetrosis-associated transmembrane protein 1 precursor Sugar_tr PF00083.24 EKX72113.1 - 7.3e-62 209.7 31.6 9.1e-62 209.4 31.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EKX72113.1 - 1.4e-12 47.2 33.0 1.3e-08 34.2 11.6 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EKX72113.1 - 6e-05 21.7 2.4 6e-05 21.7 2.4 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) CYYR1 PF10873.8 EKX72113.1 - 0.98 9.9 7.0 0.11 12.9 1.6 2.2 2 1 0 2 2 2 0 Cysteine and tyrosine-rich protein 1 FAINT PF04385.15 EKX72115.1 - 8.7e-09 35.3 7.8 0.00011 22.1 0.9 2.7 2 1 1 3 3 3 2 Domain of unknown function, DUF529 Ras PF00071.22 EKX72116.1 - 4.2e-56 189.0 0.2 5.2e-56 188.7 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKX72116.1 - 6.9e-32 110.2 0.1 1.3e-31 109.3 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKX72116.1 - 3.2e-14 52.8 0.1 4.2e-14 52.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKX72116.1 - 0.0018 17.7 0.1 0.0023 17.3 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EKX72116.1 - 0.017 15.0 0.0 0.91 9.4 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase MMR_HSR1 PF01926.23 EKX72116.1 - 0.031 14.4 0.0 0.051 13.7 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase FAINT PF04385.15 EKX72117.1 - 0.17 11.9 2.8 0.88 9.7 0.1 3.4 2 2 1 3 3 3 0 Domain of unknown function, DUF529 RRM_1 PF00076.22 EKX72118.1 - 1.7e-10 40.5 0.0 2.6e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1764 PF08576.10 EKX72119.1 - 1e-20 74.5 4.3 1.9e-20 73.6 4.3 1.5 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF1764) RasGAP_C PF03836.15 EKX72119.1 - 0.064 13.4 2.0 0.085 13.0 2.0 1.1 1 0 0 1 1 1 0 RasGAP C-terminus LRS4 PF10422.9 EKX72119.1 - 0.47 10.0 4.7 0.63 9.6 4.7 1.2 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 UPF0020 PF01170.18 EKX72120.1 - 1.2e-09 38.1 0.0 5e-08 32.9 0.0 2.6 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 EKX72120.1 - 2.8e-05 23.9 0.0 0.068 12.9 0.0 2.5 2 0 0 2 2 2 2 DNA methylase N6-adenineMlase PF10237.9 EKX72120.1 - 0.019 14.7 0.0 0.038 13.8 0.0 1.5 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase SF3a60_bindingd PF12108.8 EKX72120.1 - 0.021 14.7 0.5 0.07 13.0 0.0 2.0 2 0 0 2 2 2 0 Splicing factor SF3a60 binding domain HPTransfase PF10090.9 EKX72120.1 - 0.076 12.8 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 Histidine phosphotransferase C-terminal domain TP_methylase PF00590.20 EKX72121.1 - 4.1e-27 95.5 0.0 7e-27 94.8 0.0 1.4 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases ADK PF00406.22 EKX72122.1 - 3e-52 176.7 0.0 3.7e-52 176.4 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EKX72122.1 - 8.1e-24 84.6 0.5 1.6e-23 83.6 0.0 1.7 2 1 0 2 2 2 1 AAA domain ADK_lid PF05191.14 EKX72122.1 - 6e-14 51.7 0.0 1.2e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.6 EKX72122.1 - 6.9e-05 23.0 0.0 0.00015 22.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain Hydin_ADK PF17213.3 EKX72122.1 - 0.0014 19.0 0.0 2.1 8.6 0.0 2.4 1 1 1 2 2 2 2 Hydin Adenylate kinase-like domain AAA_18 PF13238.6 EKX72122.1 - 0.0014 19.2 0.0 0.0036 17.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain DAP3 PF10236.9 EKX72122.1 - 0.0082 15.4 0.0 0.09 11.9 0.0 2.0 2 0 0 2 2 2 1 Mitochondrial ribosomal death-associated protein 3 Homez PF11569.8 EKX72122.1 - 0.079 12.4 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez AAA_28 PF13521.6 EKX72122.1 - 0.16 12.2 0.0 0.26 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain FAINT PF04385.15 EKX72123.1 - 2.7e-51 171.5 39.5 3.5e-08 33.4 0.3 10.9 10 1 0 10 10 10 10 Domain of unknown function, DUF529 DUF2510 PF10708.9 EKX72123.1 - 0.042 13.6 1.7 10 6.0 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2510) DUF1779 PF08680.10 EKX72123.1 - 0.21 11.7 5.4 0.16 12.2 0.2 3.2 4 0 0 4 4 4 0 TATA-box binding DUF2271 PF10029.9 EKX72123.1 - 0.41 10.3 2.9 44 3.7 0.2 3.5 3 0 0 3 3 3 0 Predicted periplasmic protein (DUF2271) zf-C2H2_4 PF13894.6 EKX72124.1 - 3.1e-07 30.7 3.1 0.0037 18.0 0.1 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EKX72124.1 - 0.00037 20.7 8.7 0.058 13.7 1.9 2.4 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EKX72124.1 - 0.00084 19.7 3.4 0.021 15.3 0.1 2.5 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-met PF12874.7 EKX72124.1 - 0.012 16.0 2.6 2.1 8.9 0.3 2.4 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 EKX72124.1 - 0.026 14.4 0.3 0.026 14.4 0.3 2.2 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_2 PF12756.7 EKX72124.1 - 0.097 13.0 4.5 5.6 7.4 0.3 2.3 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) LIM PF00412.22 EKX72124.1 - 0.18 12.0 3.9 0.39 11.0 3.9 1.5 1 0 0 1 1 1 0 LIM domain TFIIS_C PF01096.18 EKX72124.1 - 0.21 11.5 1.8 2.7 7.9 0.0 2.9 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) PI-TkoII_IV PF18714.1 EKX72125.1 - 0.0029 17.1 0.1 1.1 8.7 0.0 2.2 2 0 0 2 2 2 2 DNA polymerase II intein Domain IV HA2 PF04408.23 EKX72127.1 - 6.1e-24 84.4 3.5 2.2e-22 79.4 0.0 3.1 3 0 0 3 3 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EKX72127.1 - 3.1e-15 56.3 0.0 6.3e-15 55.3 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EKX72127.1 - 6.2e-14 52.3 0.3 2.4e-13 50.4 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EKX72127.1 - 5e-06 26.8 0.0 1.9e-05 25.0 0.0 2.0 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 EKX72127.1 - 0.00046 20.0 2.1 0.0016 18.3 0.7 2.4 2 1 0 2 2 2 1 DEAD/DEAH box helicase T2SSE PF00437.20 EKX72127.1 - 0.0014 17.7 0.0 0.0027 16.8 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.6 EKX72127.1 - 0.0026 17.5 0.0 0.0049 16.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EKX72127.1 - 0.0032 17.8 0.0 0.0069 16.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 EKX72127.1 - 0.27 10.8 0.9 1.3 8.6 0.1 2.4 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain DUF4061 PF13270.6 EKX72127.1 - 0.98 9.8 4.4 0.21 11.9 0.4 2.0 2 0 0 2 2 1 0 Domain of unknown function (DUF4061) CBFB_NFYA PF02045.15 EKX72127.1 - 7.8 7.2 10.8 26 5.5 0.6 2.9 2 0 0 2 2 2 0 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B DIM1 PF02966.16 EKX72128.1 - 2.4e-62 208.6 0.8 2.8e-62 208.3 0.8 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 EKX72128.1 - 0.0068 16.4 0.1 0.0094 15.9 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin FAM76 PF16046.5 EKX72129.1 - 6.7e-22 78.2 41.2 1.3e-21 77.3 34.2 2.3 1 1 1 2 2 2 2 FAM76 protein DUF2205 PF10224.9 EKX72129.1 - 2.8e-05 24.0 0.4 5.1e-05 23.2 0.4 1.4 1 0 0 1 1 1 1 Short coiled-coil protein BLOC1_2 PF10046.9 EKX72129.1 - 0.00089 19.5 0.3 0.0017 18.6 0.3 1.5 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2046 PF09755.9 EKX72129.1 - 0.0039 16.5 0.3 0.0074 15.6 0.3 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein H4 (DUF2046) ZapB PF06005.12 EKX72129.1 - 0.004 17.6 0.9 0.0075 16.7 0.9 1.4 1 0 0 1 1 1 1 Cell division protein ZapB UPF0242 PF06785.11 EKX72129.1 - 0.0044 17.2 0.0 0.007 16.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus ADIP PF11559.8 EKX72129.1 - 0.0044 17.1 0.7 0.0074 16.4 0.7 1.3 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding betaPIX_CC PF16523.5 EKX72129.1 - 0.0095 15.7 0.1 0.018 14.9 0.1 1.4 1 0 0 1 1 1 1 betaPIX coiled coil bZIP_1 PF00170.21 EKX72129.1 - 0.011 15.8 1.9 0.028 14.5 1.9 1.7 1 0 0 1 1 1 0 bZIP transcription factor DUF4407 PF14362.6 EKX72129.1 - 0.016 14.6 0.3 0.022 14.1 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Phage_GP20 PF06810.11 EKX72129.1 - 0.017 15.0 1.1 0.026 14.3 1.1 1.3 1 0 0 1 1 1 0 Phage minor structural protein GP20 DivIC PF04977.15 EKX72129.1 - 0.017 14.9 0.5 0.037 13.8 0.5 1.5 1 0 0 1 1 1 0 Septum formation initiator TMF_DNA_bd PF12329.8 EKX72129.1 - 0.023 14.7 3.4 0.047 13.7 3.4 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Filament PF00038.21 EKX72129.1 - 0.024 14.2 0.2 0.038 13.6 0.2 1.2 1 0 0 1 1 1 0 Intermediate filament protein FlaC_arch PF05377.11 EKX72129.1 - 0.026 14.9 1.1 0.049 14.0 1.1 1.4 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Swi5 PF07061.11 EKX72129.1 - 0.027 14.5 1.0 0.055 13.6 1.0 1.4 1 0 0 1 1 1 0 Swi5 DNA_RNApol_7kD PF03604.13 EKX72129.1 - 0.033 13.9 0.6 0.033 13.9 0.6 4.5 3 1 2 5 5 4 0 DNA directed RNA polymerase, 7 kDa subunit UPF0184 PF03670.13 EKX72129.1 - 0.036 14.4 0.2 0.084 13.3 0.2 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) Atrophin-1 PF03154.15 EKX72129.1 - 0.037 12.3 0.3 0.053 11.8 0.3 1.2 1 0 0 1 1 1 0 Atrophin-1 family Mod_r PF07200.13 EKX72129.1 - 0.047 13.8 0.5 0.076 13.1 0.5 1.3 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Tmemb_cc2 PF10267.9 EKX72129.1 - 0.05 12.7 1.1 0.12 11.5 0.2 1.6 1 1 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein DUF16 PF01519.16 EKX72129.1 - 0.051 14.1 0.2 0.11 13.0 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function DUF16 LPP PF04728.13 EKX72129.1 - 0.067 13.6 0.4 0.45 10.9 0.3 2.2 1 1 1 2 2 2 0 Lipoprotein leucine-zipper DUF2443 PF10398.9 EKX72129.1 - 0.072 13.2 0.1 0.14 12.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2443) SKA2 PF16740.5 EKX72129.1 - 0.082 12.7 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 DASH_Duo1 PF08651.10 EKX72129.1 - 0.12 12.2 0.5 0.22 11.3 0.5 1.4 1 0 0 1 1 1 0 DASH complex subunit Duo1 NPV_P10 PF05531.12 EKX72129.1 - 0.13 12.7 0.4 0.21 12.1 0.4 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein SlyX PF04102.12 EKX72129.1 - 0.14 12.8 0.2 0.26 11.9 0.2 1.3 1 0 0 1 1 1 0 SlyX DUF5082 PF16888.5 EKX72129.1 - 0.16 12.3 3.6 0.24 11.7 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) NRBF2 PF08961.10 EKX72129.1 - 0.17 11.4 1.1 2.8 7.5 0.3 2.1 2 0 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator DUF948 PF06103.11 EKX72129.1 - 0.17 12.1 0.5 0.29 11.4 0.5 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) FlxA PF14282.6 EKX72129.1 - 0.23 11.5 2.3 0.38 10.8 2.3 1.3 1 0 0 1 1 1 0 FlxA-like protein Csm1_N PF18504.1 EKX72129.1 - 0.28 11.5 2.2 0.57 10.6 2.2 1.5 1 0 0 1 1 1 0 Csm1 N-terminal domain HALZ PF02183.18 EKX72129.1 - 0.85 9.9 4.4 1.7 8.9 2.7 2.1 1 1 1 2 2 2 0 Homeobox associated leucine zipper DZR PF12773.7 EKX72129.1 - 3.4 7.8 37.4 5.3 7.2 3.0 4.3 1 1 3 4 4 4 0 Double zinc ribbon FAINT PF04385.15 EKX72130.1 - 5.5e-08 32.8 1.3 0.00074 19.5 0.0 2.6 3 0 0 3 3 3 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72131.1 - 3.3e-20 71.9 0.2 0.00028 20.9 0.0 4.3 4 0 0 4 4 4 4 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72132.1 - 0.0014 18.6 3.2 0.0023 18.0 0.6 2.3 2 0 0 2 2 2 1 Domain of unknown function, DUF529 SH3_5 PF08460.10 EKX72132.1 - 0.0064 16.6 0.0 0.013 15.6 0.0 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain FAINT PF04385.15 EKX72133.1 - 3.1e-08 33.5 1.7 0.0046 17.0 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72135.1 - 0.0003 20.8 0.0 0.001 19.0 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function, DUF529 Guanylate_kin PF00625.21 EKX72137.1 - 0.059 13.0 0.3 0.084 12.5 0.3 1.2 1 0 0 1 1 1 0 Guanylate kinase FAINT PF04385.15 EKX72139.1 - 4.3e-14 52.3 0.6 3.2e-07 30.3 0.0 2.1 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Myosin-VI_CBD PF16521.5 EKX72139.1 - 0.051 13.6 0.0 0.075 13.0 0.0 1.2 1 0 0 1 1 1 0 Myosin VI cargo binding domain CDC50 PF03381.15 EKX72141.1 - 2.1e-23 83.2 1.8 2.7e-23 82.9 1.8 1.2 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family ABC_tran PF00005.27 EKX72142.1 - 4.8e-31 108.1 0.0 2.1e-17 63.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_29 PF13555.6 EKX72142.1 - 8.5e-05 22.2 0.7 0.12 12.1 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EKX72142.1 - 0.00012 22.0 0.7 0.01 15.8 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_30 PF13604.6 EKX72142.1 - 0.00013 21.8 0.1 0.072 12.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EKX72142.1 - 0.00017 22.0 0.0 0.16 12.4 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 EKX72142.1 - 0.00029 20.8 0.7 0.5 10.1 0.1 3.2 3 0 0 3 3 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DnaB_C PF03796.15 EKX72142.1 - 0.00032 20.1 0.0 0.015 14.7 0.0 2.2 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_18 PF13238.6 EKX72142.1 - 0.00077 20.0 0.1 2.1 8.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 EKX72142.1 - 0.0025 17.1 0.2 1.1 8.6 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin AAA_23 PF13476.6 EKX72142.1 - 0.0039 17.7 1.9 1.6 9.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 EKX72142.1 - 0.0041 17.2 1.6 0.15 12.1 0.1 2.6 2 0 0 2 2 2 1 Helicase HerA, central domain FtsK_SpoIIIE PF01580.18 EKX72142.1 - 0.0073 15.7 0.5 2 7.7 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family MeaB PF03308.16 EKX72142.1 - 0.0077 15.2 0.6 0.016 14.2 0.0 1.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB SMC_N PF02463.19 EKX72142.1 - 0.013 14.9 0.5 0.33 10.4 0.0 2.5 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EKX72142.1 - 0.02 15.2 0.1 3 8.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 EKX72142.1 - 0.024 13.7 0.2 4.4 6.3 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein SbcCD_C PF13558.6 EKX72142.1 - 0.024 14.9 0.0 0.06 13.6 0.0 1.7 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit TrwB_AAD_bind PF10412.9 EKX72142.1 - 0.038 12.9 0.3 5.1 5.9 0.1 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain ATP_bind_1 PF03029.17 EKX72142.1 - 0.048 13.4 0.1 10 5.8 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 EKX72142.1 - 0.054 13.5 0.1 2.8 8.0 0.0 2.4 2 0 0 2 2 2 0 Dynamin family MMR_HSR1 PF01926.23 EKX72142.1 - 0.057 13.5 0.5 0.53 10.4 0.2 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase NACHT PF05729.12 EKX72142.1 - 0.076 12.9 0.5 3.7 7.4 0.1 2.5 2 0 0 2 2 2 0 NACHT domain cobW PF02492.19 EKX72142.1 - 0.11 12.1 0.6 8.9 5.9 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_15 PF13175.6 EKX72142.1 - 0.12 12.1 0.9 13 5.3 0.1 2.3 2 0 0 2 2 2 0 AAA ATPase domain NB-ARC PF00931.22 EKX72142.1 - 0.12 11.5 0.4 2 7.5 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain AAA_25 PF13481.6 EKX72142.1 - 0.17 11.4 0.1 2.1 7.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EKX72142.1 - 0.22 11.5 0.4 5.7 6.9 0.1 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE FAINT PF04385.15 EKX72144.1 - 2e-12 47.0 0.1 5.2e-06 26.4 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72145.1 - 0.00073 19.5 1.0 0.0015 18.5 0.6 1.7 1 1 0 1 1 1 1 Domain of unknown function, DUF529 Peptidase_C1 PF00112.23 EKX72146.1 - 9.3e-21 74.9 0.0 2.2e-20 73.7 0.0 1.5 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EKX72146.1 - 0.014 15.8 0.4 0.027 14.9 0.4 1.5 1 0 0 1 1 1 0 Cathepsin propeptide inhibitor domain (I29) PLDc_N PF13396.6 EKX72146.1 - 0.017 15.0 0.3 0.048 13.6 0.3 1.8 1 0 0 1 1 1 0 Phospholipase_D-nuclease N-terminal BUD22 PF09073.10 EKX72147.1 - 0.0039 16.6 4.1 0.0071 15.7 4.1 1.4 1 0 0 1 1 1 1 BUD22 Lar_restr_allev PF14354.6 EKX72147.1 - 0.026 14.9 0.7 0.7 10.3 0.1 2.9 2 0 0 2 2 2 0 Restriction alleviation protein Lar zf-RING_14 PF17978.1 EKX72147.1 - 0.084 13.3 2.1 0.19 12.2 0.1 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-H2C2_2 PF13465.6 EKX72147.1 - 0.097 13.1 0.4 0.27 11.7 0.1 2.0 2 0 0 2 2 2 0 Zinc-finger double domain DNA_pol_phi PF04931.13 EKX72147.1 - 6.8 4.7 7.4 10 4.1 7.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi s48_45 PF07422.13 EKX72148.1 - 0.0015 19.1 13.8 0.01 16.4 3.2 3.7 4 2 0 4 4 4 2 Sexual stage antigen s48/45 domain FAINT PF04385.15 EKX72149.1 - 1.7e-17 63.2 16.4 6.9e-09 35.6 1.9 4.2 4 0 0 4 4 4 3 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72150.1 - 8e-19 67.5 2.1 1.2e-05 25.2 0.1 4.4 4 0 0 4 4 4 4 Domain of unknown function, DUF529 DUF4604 PF15377.6 EKX72150.1 - 0.072 13.5 0.2 0.14 12.6 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) FAINT PF04385.15 EKX72151.1 - 2.2e-17 62.9 0.0 0.00045 20.2 0.0 6.0 6 0 0 6 6 6 4 Domain of unknown function, DUF529 DUF4362 PF14275.6 EKX72151.1 - 0.096 13.0 0.9 12 6.3 0.0 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4362) FAINT PF04385.15 EKX72152.1 - 3e-08 33.6 0.0 0.075 13.1 0.0 3.5 3 0 0 3 3 3 3 Domain of unknown function, DUF529 GDPD PF03009.17 EKX72154.1 - 7.4e-11 42.3 0.0 4.8e-07 29.8 0.0 2.4 2 1 0 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family DUF433 PF04255.14 EKX72154.1 - 0.031 14.1 0.0 13 5.7 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF433) Usg PF06233.12 EKX72154.1 - 0.11 12.6 0.0 0.36 11.0 0.0 1.8 2 0 0 2 2 2 0 Usg-like family DUF2076 PF09849.9 EKX72155.1 - 1.8 8.5 12.3 0.12 12.4 1.1 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) HSBP1 PF06825.12 EKX72156.1 - 0.048 13.5 0.6 0.1 12.4 0.6 1.5 1 0 0 1 1 1 0 Heat shock factor binding protein 1 PaREP1 PF05942.11 EKX72156.1 - 0.95 9.4 11.6 0.028 14.3 4.1 2.0 1 1 1 2 2 2 0 Archaeal PaREP1/PaREP8 family Syntaxin PF00804.25 EKX72156.1 - 2.6 7.7 15.1 0.12 12.1 4.9 2.8 2 1 1 3 3 3 0 Syntaxin VSG_B PF13206.6 EKX72156.1 - 6 6.0 20.8 14 4.8 20.8 1.6 1 1 0 1 1 1 0 Trypanosomal VSG domain DUF572 PF04502.13 EKX72158.1 - 1.8e-50 172.4 7.8 2.1e-50 172.3 7.8 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) Rubredoxin_2 PF18073.1 EKX72158.1 - 0.02 14.6 3.3 0.031 14.0 0.2 2.2 2 0 0 2 2 2 0 Rubredoxin metal binding domain INCENP_ARK-bind PF03941.15 EKX72158.1 - 0.048 13.6 0.9 0.13 12.2 0.9 1.7 1 0 0 1 1 1 0 Inner centromere protein, ARK binding region zf-ACC PF17848.1 EKX72158.1 - 0.11 12.5 1.1 6.2 7.0 0.2 2.5 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain TF_Zn_Ribbon PF08271.12 EKX72158.1 - 4.4 6.9 5.7 0.4 10.2 0.3 2.0 2 0 0 2 2 2 0 TFIIB zinc-binding FAINT PF04385.15 EKX72159.1 - 6.3e-23 80.6 1.8 1.1e-05 25.4 0.0 4.3 4 0 0 4 4 4 4 Domain of unknown function, DUF529 DUF1966 PF09260.11 EKX72159.1 - 0.043 14.1 0.0 0.15 12.3 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1966) A2L_zn_ribbon PF08792.10 EKX72159.1 - 0.068 12.9 0.5 0.25 11.1 0.5 1.9 1 0 0 1 1 1 0 A2L zinc ribbon domain PAPS_reduct PF01507.19 EKX72160.1 - 1.3e-14 54.7 0.0 1.4e-14 54.5 0.0 1.1 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family FAINT PF04385.15 EKX72161.1 - 2.6e-15 56.2 7.2 1.1e-09 38.2 0.2 3.8 3 2 0 3 3 3 2 Domain of unknown function, DUF529 EMA PF02488.15 EKX72161.1 - 3e-07 30.4 11.2 0.0023 17.6 0.5 3.1 2 1 1 3 3 3 3 Merozoite Antigen FAINT PF04385.15 EKX72162.1 - 6e-09 35.9 0.4 1.1e-08 35.0 0.4 1.5 1 0 0 1 1 1 1 Domain of unknown function, DUF529 PAPS_reduct PF01507.19 EKX72162.1 - 3.4e-06 27.2 0.0 6e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family RRM_1 PF00076.22 EKX72165.1 - 2.4e-16 59.3 0.0 4.6e-16 58.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 EKX72165.1 - 0.088 12.8 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 RL domain Nup35_RRM_2 PF14605.6 EKX72165.1 - 0.11 12.6 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Elf1 PF05129.13 EKX72167.1 - 0.27 11.3 3.1 2.4 8.3 0.3 3.7 4 0 0 4 4 4 0 Transcription elongation factor Elf1 like Myb_DNA-bind_4 PF13837.6 EKX72167.1 - 4.5 7.7 8.4 60 4.1 0.3 5.4 6 0 0 6 6 6 0 Myb/SANT-like DNA-binding domain FAINT PF04385.15 EKX72168.1 - 0.014 15.5 1.4 0.25 11.4 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72170.1 - 2.1e-11 43.7 2.0 3.5e-07 30.2 0.1 2.7 3 0 0 3 3 3 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72172.1 - 6.8e-10 38.9 0.6 2.6e-05 24.2 0.5 3.0 2 1 0 2 2 2 2 Domain of unknown function, DUF529 ChitinaseA_N PF08329.10 EKX72172.1 - 0.06 13.0 0.2 3.6 7.2 0.0 2.9 2 1 1 3 3 3 0 Chitinase A, N-terminal domain FAINT PF04385.15 EKX72173.1 - 1.1e-23 83.1 2.0 6.3e-07 29.4 0.0 4.8 4 1 0 4 4 4 4 Domain of unknown function, DUF529 AsmA PF05170.14 EKX72174.1 - 0.1 11.4 0.2 0.17 10.7 0.2 1.2 1 0 0 1 1 1 0 AsmA family FAINT PF04385.15 EKX72175.1 - 1.1e-12 47.8 7.4 0.00015 21.7 0.3 3.9 4 0 0 4 4 4 3 Domain of unknown function, DUF529 Thioredoxin_8 PF13905.6 EKX72175.1 - 1.4e-05 25.3 0.1 0.033 14.5 0.0 3.3 3 2 1 4 4 4 2 Thioredoxin-like DUF237 PF03072.14 EKX72175.1 - 0.02 14.9 0.0 0.87 9.6 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF237) Smg8_Smg9 PF10220.9 EKX72175.1 - 0.069 11.5 0.0 0.089 11.1 0.0 1.0 1 0 0 1 1 1 0 Smg8_Smg9 FAINT PF04385.15 EKX72176.1 - 5.8e-07 29.5 0.0 7.8e-05 22.7 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72178.1 - 0.035 14.2 0.0 0.045 13.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72179.1 - 4.9e-09 36.1 0.0 0.00056 19.9 0.0 2.9 3 0 0 3 3 3 2 Domain of unknown function, DUF529 RVT_1 PF00078.27 EKX72182.1 - 2.2e-28 99.3 0.1 3.2e-28 98.8 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF5098 PF17023.5 EKX72182.1 - 0.15 11.0 1.8 8.2 5.3 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5098) FAINT PF04385.15 EKX72183.1 - 2.7e-11 43.4 5.6 0.0033 17.5 0.1 4.6 3 1 1 4 4 4 3 Domain of unknown function, DUF529 DUF1735 PF08522.10 EKX72184.1 - 0.069 13.8 0.1 0.14 12.7 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1735) DUF4884 PF16225.5 EKX72186.1 - 0.12 12.5 2.0 5.4 7.2 0.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4884) FAINT PF04385.15 EKX72187.1 - 0.015 15.3 0.0 0.027 14.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function, DUF529 Scytalone_dh PF02982.14 EKX72187.1 - 0.03 14.1 0.0 0.04 13.7 0.0 1.2 1 0 0 1 1 1 0 Scytalone dehydratase Flavodoxin_1 PF00258.25 EKX72190.1 - 2e-22 79.9 1.3 2.4e-22 79.7 0.3 1.7 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 EKX72190.1 - 3.7e-13 50.1 0.0 1e-12 48.6 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_1 PF00667.20 EKX72190.1 - 4.1e-11 42.9 0.0 9.4e-11 41.7 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain FAINT PF04385.15 EKX72192.1 - 3.3e-05 23.8 2.5 0.028 14.5 0.0 3.2 4 0 0 4 4 4 2 Domain of unknown function, DUF529 RRP14 PF15459.6 EKX72192.1 - 0.029 15.0 1.5 0.32 11.6 0.0 2.7 3 0 0 3 3 3 0 60S ribosome biogenesis protein Rrp14 MscL PF01741.18 EKX72193.1 - 0.073 13.4 0.6 0.17 12.2 0.6 1.6 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL MscL PF01741.18 EKX72194.1 - 0.089 13.1 1.3 0.2 12.0 1.3 1.6 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL AP2 PF00847.20 EKX72196.1 - 3.2e-10 40.1 1.3 3.2e-10 40.1 1.3 1.8 2 0 0 2 2 2 1 AP2 domain Filamin PF00630.19 EKX72197.1 - 9e-10 39.3 0.0 5.2e-05 24.0 0.0 2.5 2 0 0 2 2 2 2 Filamin/ABP280 repeat SAS4 PF15460.6 EKX72197.1 - 0.87 9.7 8.2 1.6 8.8 5.7 2.4 1 1 1 2 2 2 0 Something about silencing, SAS, complex subunit 4 ISG65-75 PF11727.8 EKX72197.1 - 1.6 7.9 6.7 0.28 10.4 0.9 2.1 2 1 0 2 2 2 0 Invariant surface glycoprotein DUF2408 PF10303.9 EKX72197.1 - 1.8 9.1 6.6 4.2 8.0 6.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) DUF745 PF05335.13 EKX72197.1 - 2.7 7.7 7.5 2.8 7.6 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF745) DUF848 PF05852.11 EKX72197.1 - 2.9 8.0 8.8 1.5 9.0 3.3 2.4 1 1 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) CRAL_TRIO_2 PF13716.6 EKX72198.1 - 1e-17 64.6 1.7 2.4e-17 63.4 1.7 1.6 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain RhoGAP PF00620.27 EKX72198.1 - 1.6e-07 31.3 0.0 3.1e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain FAINT PF04385.15 EKX72200.1 - 1.1e-07 31.8 1.3 1.8e-07 31.1 1.3 1.3 1 0 0 1 1 1 1 Domain of unknown function, DUF529 Arfaptin PF06456.13 EKX72200.1 - 0.0011 18.6 0.4 0.0017 18.0 0.4 1.2 1 0 0 1 1 1 1 Arfaptin-like domain HMG_box_5 PF14887.6 EKX72200.1 - 0.015 15.3 0.6 0.84 9.6 0.1 2.8 2 1 1 3 3 3 0 HMG (high mobility group) box 5 COG2 PF06148.11 EKX72200.1 - 0.074 13.1 0.4 0.14 12.3 0.4 1.3 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 TMP_2 PF06791.13 EKX72200.1 - 0.093 12.4 0.3 0.22 11.1 0.3 1.6 1 0 0 1 1 1 0 Prophage tail length tape measure protein MSP1_C PF07462.11 EKX72200.1 - 2.2 6.9 9.6 0.24 10.0 0.3 2.4 3 0 0 3 3 3 0 Merozoite surface protein 1 (MSP1) C-terminus FAINT PF04385.15 EKX72201.1 - 6.4e-20 71.0 0.2 2e-05 24.5 0.0 3.8 3 1 0 3 3 3 3 Domain of unknown function, DUF529 Peptidase_C1 PF00112.23 EKX72203.1 - 4.8e-49 167.4 0.4 7.4e-49 166.8 0.4 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EKX72203.1 - 1.9e-06 27.0 0.3 4.7e-06 25.7 0.1 1.7 2 0 0 2 2 2 1 Peptidase C1-like family Inhibitor_I29 PF08246.12 EKX72203.1 - 0.18 12.3 0.2 0.36 11.3 0.2 1.5 1 0 0 1 1 1 0 Cathepsin propeptide inhibitor domain (I29) FAINT PF04385.15 EKX72204.1 - 0.00038 20.5 2.7 0.00038 20.5 2.7 3.9 3 1 1 4 4 4 1 Domain of unknown function, DUF529 DUF5590 PF17881.1 EKX72204.1 - 0.0044 17.1 0.9 0.13 12.4 0.0 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF5590) FAINT PF04385.15 EKX72205.1 - 4.5e-05 23.4 0.8 0.42 10.7 0.1 3.2 3 1 0 3 3 3 2 Domain of unknown function, DUF529 ABC_tran PF00005.27 EKX72206.1 - 5.2e-34 117.7 0.0 2.4e-17 63.8 0.0 3.5 3 0 0 3 3 3 2 ABC transporter AAA_16 PF13191.6 EKX72206.1 - 4.3e-06 27.2 0.3 0.024 15.0 0.0 2.9 3 0 0 3 3 3 2 AAA ATPase domain AAA_21 PF13304.6 EKX72206.1 - 1.2e-05 25.2 3.8 0.19 11.5 0.2 4.0 5 0 0 5 5 4 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EKX72206.1 - 6.5e-05 22.9 3.3 0.017 15.0 0.1 2.6 3 0 0 3 3 2 2 RsgA GTPase AAA_29 PF13555.6 EKX72206.1 - 6.7e-05 22.6 5.2 0.14 12.0 0.1 3.0 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_18 PF13238.6 EKX72206.1 - 7.4e-05 23.3 0.5 0.87 10.1 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.6 EKX72206.1 - 0.00012 21.9 0.9 0.11 12.2 0.0 2.8 3 0 0 3 3 3 2 AAA domain DUF87 PF01935.17 EKX72206.1 - 0.00042 20.5 1.8 0.071 13.2 0.1 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain MMR_HSR1 PF01926.23 EKX72206.1 - 0.0006 19.9 0.6 0.18 11.9 0.0 3.4 3 0 0 3 3 3 1 50S ribosome-binding GTPase MeaB PF03308.16 EKX72206.1 - 0.00082 18.4 0.4 0.013 14.5 0.1 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 EKX72206.1 - 0.00092 18.5 0.2 0.37 10.0 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_22 PF13401.6 EKX72206.1 - 0.0019 18.5 0.5 0.54 10.5 0.0 3.0 3 0 0 3 3 3 1 AAA domain FtsK_SpoIIIE PF01580.18 EKX72206.1 - 0.0019 17.6 0.8 0.33 10.3 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family SMC_N PF02463.19 EKX72206.1 - 0.0025 17.3 0.9 0.033 13.6 0.1 2.5 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain DnaB_C PF03796.15 EKX72206.1 - 0.0041 16.5 0.0 0.19 11.0 0.0 2.3 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain Fer4_NifH PF00142.18 EKX72206.1 - 0.0048 16.4 0.2 2.3 7.6 0.0 2.3 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Dynamin_N PF00350.23 EKX72206.1 - 0.0074 16.4 3.1 0.79 9.8 0.1 3.3 3 0 0 3 3 3 1 Dynamin family DUF815 PF05673.13 EKX72206.1 - 0.015 14.4 0.3 0.45 9.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) T2SSE PF00437.20 EKX72206.1 - 0.016 14.3 1.5 2 7.4 0.1 2.5 3 0 0 3 3 3 0 Type II/IV secretion system protein AAA_15 PF13175.6 EKX72206.1 - 0.034 13.9 2.2 3.8 7.1 0.4 2.5 2 0 0 2 2 2 0 AAA ATPase domain ATP_bind_1 PF03029.17 EKX72206.1 - 0.048 13.4 0.1 5.2 6.8 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein IstB_IS21 PF01695.17 EKX72206.1 - 0.049 13.4 0.1 1.7 8.4 0.0 2.7 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_23 PF13476.6 EKX72206.1 - 0.065 13.7 12.3 0.1 13.1 1.1 3.0 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 EKX72206.1 - 0.084 13.3 0.0 11 6.4 0.0 3.0 2 0 0 2 2 2 0 RNA helicase DUF2791 PF10923.8 EKX72206.1 - 0.093 11.6 0.0 0.86 8.4 0.0 2.1 2 0 0 2 2 2 0 P-loop Domain of unknown function (DUF2791) NB-ARC PF00931.22 EKX72206.1 - 0.093 11.9 0.5 1.2 8.2 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain AAA_10 PF12846.7 EKX72206.1 - 0.11 11.4 0.2 5.4 5.8 0.0 2.2 2 0 0 2 2 2 0 AAA-like domain AAA_25 PF13481.6 EKX72206.1 - 0.12 12.0 0.1 3.1 7.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 EKX72206.1 - 0.18 12.1 0.0 0.37 11.1 0.0 1.4 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit NACHT PF05729.12 EKX72206.1 - 0.25 11.2 3.7 8.4 6.3 0.1 2.7 3 0 0 3 3 2 0 NACHT domain AAA_27 PF13514.6 EKX72206.1 - 0.25 10.9 0.6 16 5.0 0.0 2.8 3 0 0 3 3 3 0 AAA domain cobW PF02492.19 EKX72206.1 - 0.38 10.3 3.4 7.7 6.1 0.0 2.9 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 EKX72206.1 - 5.9 7.1 6.4 46 4.2 0.1 3.5 4 0 0 4 4 3 0 AAA domain FAINT PF04385.15 EKX72207.1 - 4.5e-11 42.7 1.4 7.7e-06 25.9 0.6 2.7 2 1 0 2 2 2 2 Domain of unknown function, DUF529 Glyco_hydro_79C PF16862.5 EKX72207.1 - 0.031 15.2 0.4 0.15 13.0 0.1 2.2 1 1 1 2 2 2 0 Glycosyl hydrolase family 79 C-terminal beta domain UPF0160 PF03690.13 EKX72208.1 - 0.053 13.2 0.0 0.092 12.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0160) FAINT PF04385.15 EKX72209.1 - 5.9e-06 26.2 0.0 1.2e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function, DUF529 zf-RING_2 PF13639.6 EKX72211.1 - 4.1e-09 36.6 4.1 2.8e-08 33.9 1.6 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EKX72211.1 - 1.2e-06 28.2 3.7 6.1e-06 26.0 1.2 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EKX72211.1 - 4e-06 27.0 3.6 9.4e-06 25.8 3.6 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EKX72211.1 - 7.3e-05 22.6 0.6 7.3e-05 22.6 0.6 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EKX72211.1 - 0.00013 21.7 2.7 0.00025 20.8 0.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EKX72211.1 - 0.00045 20.0 3.0 0.0012 18.6 3.0 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EKX72211.1 - 0.00073 19.5 5.4 0.0039 17.2 5.4 2.1 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 EKX72211.1 - 0.0011 18.7 1.5 0.0038 16.9 0.4 2.4 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_5 PF14634.6 EKX72211.1 - 0.0064 16.4 2.1 0.02 14.9 0.3 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EKX72211.1 - 0.013 15.5 0.2 0.027 14.5 0.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EKX72211.1 - 0.02 14.5 0.6 0.064 12.9 0.6 1.8 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 EKX72211.1 - 4 7.7 5.4 0.42 10.8 0.8 1.8 2 0 0 2 2 1 0 zinc finger of C3HC4-type, RING DUF2053 PF09767.9 EKX72212.1 - 1.1e-17 64.7 8.2 1.7e-17 64.0 8.2 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2053) DUF5313 PF17240.2 EKX72212.1 - 0.23 11.9 0.7 2.3 8.7 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5313) DJ-1_PfpI PF01965.24 EKX72213.1 - 7e-33 113.8 0.1 8.4e-33 113.5 0.1 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family Filament_head PF04732.14 EKX72214.1 - 1.8 9.5 11.7 0.15 13.0 2.3 3.4 3 0 0 3 3 3 0 Intermediate filament head (DNA binding) region FAINT PF04385.15 EKX72215.1 - 1e-79 262.6 40.7 3.4e-09 36.6 0.2 13.6 13 0 0 13 13 13 13 Domain of unknown function, DUF529 WIYLD PF10440.9 EKX72215.1 - 3.3 7.6 7.3 1.9 8.3 0.2 3.6 3 0 0 3 3 3 0 Ubiquitin-binding WIYLD domain Peptidase_C1 PF00112.23 EKX72216.1 - 3.6e-28 99.1 0.0 5.8e-28 98.5 0.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Piezo_RRas_bdg PF12166.8 EKX72216.1 - 0.076 12.3 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain DASH_Duo1 PF08651.10 EKX72218.1 - 0.0026 17.5 0.0 0.11 12.3 0.0 2.9 2 1 1 3 3 3 1 DASH complex subunit Duo1 JHD PF17811.1 EKX72219.1 - 0.1 13.1 1.3 0.51 10.9 0.1 2.2 1 1 0 2 2 2 0 Jumonji helical domain FAINT PF04385.15 EKX72220.1 - 2.5e-14 53.1 0.2 5.5e-06 26.4 0.0 3.7 3 0 0 3 3 3 3 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72222.1 - 1e-08 35.1 0.0 0.0041 17.1 0.0 3.8 3 0 0 3 3 3 3 Domain of unknown function, DUF529 Ribosomal_L18p PF00861.22 EKX72222.1 - 1.7e-08 34.8 0.0 1.9e-07 31.4 0.0 2.1 1 1 0 1 1 1 1 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast Nop14 PF04147.12 EKX72223.1 - 0.088 11.0 2.7 0.13 10.5 2.7 1.1 1 0 0 1 1 1 0 Nop14-like family Ribosomal_L2 PF00181.23 EKX72226.1 - 0.017 15.0 0.4 0.032 14.2 0.4 1.4 1 0 0 1 1 1 0 Ribosomal Proteins L2, RNA binding domain FAINT PF04385.15 EKX72227.1 - 1e-08 35.1 0.1 0.0039 17.2 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 DUF2098 PF09871.9 EKX72227.1 - 0.086 13.2 0.0 0.33 11.3 0.0 2.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) Sec1 PF00995.23 EKX72228.1 - 1.3e-87 295.4 6.7 5.5e-87 293.3 6.7 1.7 1 1 0 1 1 1 1 Sec1 family FAM163 PF15069.6 EKX72229.1 - 0.057 13.9 0.0 0.079 13.4 0.0 1.2 1 0 0 1 1 1 0 FAM163 family DUF1347 PF07079.11 EKX72230.1 - 0.024 13.2 0.2 0.031 12.9 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1347) DUF1616 PF07760.11 EKX72231.1 - 0.084 12.2 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1616) FAINT PF04385.15 EKX72232.1 - 7.1e-94 308.0 115.7 2e-06 27.7 3.9 27.0 26 0 0 26 26 26 24 Domain of unknown function, DUF529 Viral_P18 PF04521.13 EKX72232.1 - 0.0068 16.2 0.0 0.018 14.8 0.0 1.7 1 0 0 1 1 1 1 ssRNA positive strand viral 18kD cysteine rich protein DEDD_Tnp_IS110 PF01548.17 EKX72232.1 - 0.03 14.2 0.0 0.17 11.7 0.0 2.3 2 0 0 2 2 2 0 Transposase NOT2_3_5 PF04153.18 EKX72232.1 - 0.19 11.8 5.9 1.1 9.4 0.3 3.3 2 0 0 2 2 2 0 NOT2 / NOT3 / NOT5 family DUF1863 PF08937.11 EKX72232.1 - 0.86 9.9 4.8 0.37 11.1 0.6 2.5 2 0 0 2 2 2 0 MTH538 TIR-like domain (DUF1863) FAINT PF04385.15 EKX72233.1 - 1e-05 25.5 0.2 1.5e-05 25.0 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72234.1 - 1.5e-14 53.8 0.8 5.5e-06 26.4 0.0 3.0 2 1 1 3 3 3 2 Domain of unknown function, DUF529 DUF3512 PF12024.8 EKX72234.1 - 0.0041 16.7 0.7 0.76 9.2 0.2 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF3512) FAINT PF04385.15 EKX72235.1 - 0.00052 20.0 1.7 0.001 19.1 1.2 1.9 1 1 0 1 1 1 1 Domain of unknown function, DUF529 DUF4467 PF14729.6 EKX72235.1 - 0.11 12.9 1.3 0.91 9.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function with cystatin-like fold (DUF4467) FAINT PF04385.15 EKX72236.1 - 8.7e-09 35.3 5.2 1.3e-05 25.2 0.2 2.7 3 0 0 3 3 3 2 Domain of unknown function, DUF529 FAD_binding_9 PF08021.11 EKX72236.1 - 0.0016 18.7 0.0 3.1 8.0 0.0 2.6 2 1 0 2 2 2 2 Siderophore-interacting FAD-binding domain NOG1_N PF17835.1 EKX72237.1 - 0.0052 16.8 9.4 0.22 11.4 0.0 4.4 4 1 1 5 5 5 2 NOG1 N-terminal helical domain DUF1043 PF06295.12 EKX72237.1 - 0.097 12.7 15.9 2.5 8.1 0.0 4.3 3 1 1 4 4 4 0 Protein of unknown function (DUF1043) DUF2524 PF10732.9 EKX72237.1 - 0.18 12.1 10.2 1.4 9.3 0.2 4.4 4 0 0 4 4 4 0 Protein of unknown function (DUF2524) HsbA PF12296.8 EKX72237.1 - 0.35 11.3 0.1 0.35 11.3 0.1 3.4 3 1 1 4 4 4 0 Hydrophobic surface binding protein A V_ATPase_I PF01496.19 EKX72237.1 - 0.51 8.2 24.2 0.6 8.0 23.1 1.6 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2935 PF11155.8 EKX72237.1 - 0.56 10.5 8.2 16 5.8 3.7 3.8 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) ParE_toxin PF05016.15 EKX72237.1 - 0.63 10.7 3.1 3.3 8.4 0.2 3.1 3 0 0 3 3 3 0 ParE toxin of type II toxin-antitoxin system, parDE DHR10 PF18595.1 EKX72237.1 - 0.68 10.0 36.9 0.089 12.9 7.8 4.6 5 0 0 5 5 5 0 Designed helical repeat protein 10 domain WXG100 PF06013.12 EKX72237.1 - 1.3 9.3 7.5 56 4.1 0.0 5.0 5 2 1 6 6 6 0 Proteins of 100 residues with WXG DUF1840 PF08895.11 EKX72237.1 - 1.9 8.9 11.0 5.6 7.3 0.2 3.8 3 1 1 4 4 4 0 Domain of unknown function (DUF1840) ECH_2 PF16113.5 EKX72237.1 - 3.4 7.1 16.1 0.3 10.5 2.1 3.0 2 1 1 3 3 3 0 Enoyl-CoA hydratase/isomerase FAINT PF04385.15 EKX72238.1 - 0.0081 16.2 0.0 0.021 14.9 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function, DUF529 TDH PF03347.13 EKX72238.1 - 0.05 13.2 0.0 0.075 12.6 0.0 1.3 1 0 0 1 1 1 0 Vibrio thermostable direct hemolysin FAINT PF04385.15 EKX72239.1 - 1.1e-11 44.6 4.7 8e-07 29.0 0.4 2.3 2 0 0 2 2 2 2 Domain of unknown function, DUF529 LMF1 PF06762.14 EKX72240.1 - 1.1e-79 268.6 2.3 1.9e-79 267.9 2.3 1.3 1 0 0 1 1 1 1 Lipase maturation factor FAINT PF04385.15 EKX72241.1 - 0.013 15.5 0.2 0.026 14.6 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function, DUF529 Pyr_redox_2 PF07992.14 EKX72242.1 - 7.2e-53 179.7 0.3 9.1e-53 179.4 0.3 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EKX72242.1 - 4.6e-26 91.2 0.0 1.3e-25 89.8 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EKX72242.1 - 2.4e-15 56.8 1.2 2.7e-12 47.1 0.1 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EKX72242.1 - 8.2e-09 35.1 1.6 7.4e-05 22.1 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EKX72242.1 - 2.9e-07 30.0 0.0 9e-06 25.1 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.24 EKX72242.1 - 2.2e-06 27.0 1.6 8e-06 25.2 0.3 2.2 2 0 0 2 2 2 1 FAD binding domain AlaDh_PNT_C PF01262.21 EKX72242.1 - 2.1e-05 23.9 0.2 0.038 13.3 0.1 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EKX72242.1 - 0.00018 20.4 0.6 0.00043 19.1 0.2 1.8 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 EKX72242.1 - 0.00018 21.0 0.4 0.00027 20.4 0.4 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 EKX72242.1 - 0.0011 18.1 0.3 0.0017 17.5 0.3 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EKX72242.1 - 0.0018 18.5 4.2 0.0021 18.2 0.2 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EKX72242.1 - 0.0088 15.3 0.3 0.014 14.6 0.3 1.3 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 EKX72242.1 - 0.017 14.7 0.2 0.039 13.5 0.2 1.6 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EKX72242.1 - 0.04 13.2 0.0 0.08 12.2 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain NAD_binding_7 PF13241.6 EKX72242.1 - 0.099 13.1 0.2 9 6.8 0.0 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding MRC1 PF09444.10 EKX72243.1 - 0.21 12.1 0.1 0.42 11.1 0.1 1.4 1 0 0 1 1 1 0 MRC1-like domain Cnd2 PF05786.14 EKX72244.1 - 1.6e-28 99.8 19.0 1.4e-20 73.6 5.9 3.5 1 1 0 2 2 2 2 Condensin complex subunit 2 CNDH2_N PF06278.11 EKX72244.1 - 0.00025 21.2 0.0 0.00025 21.2 0.0 2.6 3 0 0 3 3 3 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal FAINT PF04385.15 EKX72245.1 - 5e-20 71.3 9.2 5.9e-05 23.1 0.0 4.9 5 0 0 5 5 5 4 Domain of unknown function, DUF529 zf-SNAP50_C PF12251.8 EKX72245.1 - 0.47 10.1 4.2 4 7.1 0.1 3.0 3 0 0 3 3 3 0 snRNA-activating protein of 50kDa MW C terminal FAINT PF04385.15 EKX72246.1 - 8.4e-32 109.1 1.8 3.7e-05 23.7 0.0 6.5 6 0 0 6 6 6 5 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72249.1 - 1.3e-10 41.1 2.2 7.3e-08 32.4 0.4 2.8 2 1 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72250.1 - 1.8e-11 43.9 9.1 8.8e-07 28.9 0.5 4.2 3 2 1 4 4 4 3 Domain of unknown function, DUF529 Zip PF02535.22 EKX72250.1 - 1.4 8.1 14.8 0.022 14.0 0.9 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter FAINT PF04385.15 EKX72251.1 - 1.5e-46 156.4 31.3 3.1e-11 43.2 0.3 9.9 9 0 0 9 9 9 9 Domain of unknown function, DUF529 ThiC_Rad_SAM PF01964.18 EKX72251.1 - 0.061 12.1 0.0 0.48 9.2 0.0 2.0 2 0 0 2 2 2 0 Radical SAM ThiC family ESP PF16590.5 EKX72251.1 - 4.9 7.5 5.2 2.4 8.5 0.6 3.0 2 0 0 2 2 2 0 Exocrine gland-secreting peptide SDA1 PF05285.12 EKX72252.1 - 6.3e-18 65.3 65.9 5e-10 39.3 43.8 3.2 2 1 1 3 3 3 2 SDA1 IBP39 PF11422.8 EKX72252.1 - 0.033 14.0 1.0 0.07 12.9 0.2 1.9 2 0 0 2 2 2 0 Initiator binding protein 39 kDa DUF2457 PF10446.9 EKX72252.1 - 0.041 13.0 27.6 0.31 10.1 29.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) Atrophin-1 PF03154.15 EKX72252.1 - 1 7.6 9.8 1.3 7.2 9.8 1.1 1 0 0 1 1 1 0 Atrophin-1 family BUD22 PF09073.10 EKX72252.1 - 2.2 7.6 40.5 0.061 12.7 32.4 2.0 1 1 1 2 2 2 0 BUD22 Collagen PF01391.18 EKX72253.1 - 0.059 13.1 13.8 0.2 11.5 13.8 1.8 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Tfb5 PF06331.12 EKX72255.1 - 1.4e-05 25.0 0.3 2.6e-05 24.1 0.2 1.6 1 1 1 2 2 2 1 Transcription factor TFIIH complex subunit Tfb5 Arf PF00025.21 EKX72256.1 - 3.1e-41 140.7 0.1 5.7e-41 139.9 0.1 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EKX72256.1 - 7.9e-06 26.1 0.0 1.9e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EKX72256.1 - 4e-05 22.9 0.1 9.2e-05 21.8 0.1 1.5 1 0 0 1 1 1 1 G-protein alpha subunit SRPRB PF09439.10 EKX72256.1 - 0.003 17.0 0.0 0.0059 16.1 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EKX72256.1 - 0.014 15.0 0.0 0.03 13.9 0.0 1.5 1 0 0 1 1 1 0 Ras family Gtr1_RagA PF04670.12 EKX72256.1 - 0.015 14.7 0.0 0.033 13.6 0.0 1.5 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Arf PF00025.21 EKX72257.1 - 8.4e-19 67.7 0.3 8.9e-19 67.6 0.3 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EKX72257.1 - 0.00046 19.5 0.1 0.00046 19.5 0.1 1.1 1 0 0 1 1 1 1 G-protein alpha subunit MMR_HSR1 PF01926.23 EKX72257.1 - 0.001 19.1 0.1 0.0012 18.9 0.1 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EKX72257.1 - 0.0013 18.9 0.0 0.0016 18.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EKX72257.1 - 0.0033 16.9 0.0 0.0036 16.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EKX72257.1 - 0.077 12.7 0.0 0.09 12.5 0.0 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.6 EKX72257.1 - 0.11 13.1 0.1 0.11 13.1 0.1 1.1 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 EKX72257.1 - 0.12 11.7 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Bacterial TniB protein FAINT PF04385.15 EKX72258.1 - 7.1e-06 26.0 0.0 1.2e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 DUF4337 PF14235.6 EKX72259.1 - 6.7 6.8 8.2 10 6.2 8.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) FAINT PF04385.15 EKX72260.1 - 0.075 13.1 0.1 0.16 12.0 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function, DUF529 MMU163 PF17119.5 EKX72260.1 - 0.12 11.5 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis FAINT PF04385.15 EKX72261.1 - 2.7e-20 72.2 0.5 0.039 14.0 0.0 5.9 5 0 0 5 5 5 5 Domain of unknown function, DUF529 Collagen PF01391.18 EKX72262.1 - 0.17 11.7 9.9 0.22 11.3 9.9 1.3 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) HEAT PF02985.22 EKX72265.1 - 0.0071 16.5 0.2 0.026 14.8 0.0 2.0 2 0 0 2 2 2 1 HEAT repeat HEAT_2 PF13646.6 EKX72265.1 - 0.0097 16.3 0.0 0.018 15.4 0.0 1.4 1 0 0 1 1 1 1 HEAT repeats MGC-24 PF05283.11 EKX72266.1 - 0.092 13.2 0.1 0.092 13.2 0.1 1.7 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin HEAT_2 PF13646.6 EKX72267.1 - 0.00012 22.4 0.0 0.0011 19.3 0.0 2.5 2 0 0 2 2 2 1 HEAT repeats HEAT PF02985.22 EKX72267.1 - 0.023 14.9 0.0 2 8.9 0.0 2.9 2 0 0 2 2 2 0 HEAT repeat EMA PF02488.15 EKX72270.1 - 0.00022 21.0 0.3 0.00034 20.4 0.3 1.2 1 0 0 1 1 1 1 Merozoite Antigen RVT_1 PF00078.27 EKX72272.1 - 4.4e-20 72.1 0.0 5.1e-20 71.9 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FAINT PF04385.15 EKX72274.1 - 1.4e-07 31.5 0.2 0.0067 16.5 0.7 2.6 2 1 0 2 2 2 2 Domain of unknown function, DUF529 Laminin_II PF06009.12 EKX72275.1 - 0.071 13.1 2.5 2.2 8.3 0.5 2.1 1 1 1 2 2 2 0 Laminin Domain II V_ATPase_I PF01496.19 EKX72275.1 - 0.086 10.8 0.5 0.17 9.8 0.5 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family IFT20 PF14931.6 EKX72275.1 - 0.12 12.5 2.8 0.19 11.9 1.1 2.0 1 1 1 2 2 2 0 Intraflagellar transport complex B, subunit 20 PTS_IIA PF02255.16 EKX72275.1 - 0.16 12.0 2.3 1.1 9.3 0.3 2.3 1 1 1 2 2 2 0 PTS system, Lactose/Cellobiose specific IIA subunit TPR_MLP1_2 PF07926.12 EKX72275.1 - 0.17 11.9 4.6 0.29 11.2 4.6 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Muted PF14942.6 EKX72275.1 - 0.32 11.4 2.9 0.53 10.6 2.1 1.7 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein COG2 PF06148.11 EKX72275.1 - 0.55 10.3 3.3 0.69 10.0 1.0 2.0 1 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1664 PF07889.12 EKX72275.1 - 0.69 10.0 2.3 7 6.7 1.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ATP-synt_DE PF00401.20 EKX72275.1 - 0.88 9.9 3.5 3.8 7.8 0.2 2.4 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain Ribosomal_L37ae PF01780.19 EKX72277.1 - 0.12 12.5 1.4 0.24 11.5 1.4 1.4 1 0 0 1 1 1 0 Ribosomal L37ae protein family FAINT PF04385.15 EKX72279.1 - 2.7e-06 27.3 0.1 0.066 13.3 0.0 2.7 2 1 0 2 2 2 2 Domain of unknown function, DUF529 EMA PF02488.15 EKX72279.1 - 0.00044 20.0 0.0 0.00063 19.5 0.0 1.3 1 0 0 1 1 1 1 Merozoite Antigen FAINT PF04385.15 EKX72281.1 - 2.1e-05 24.5 0.4 6.5e-05 22.9 0.2 1.9 1 1 1 2 2 2 1 Domain of unknown function, DUF529 MscL PF01741.18 EKX72282.1 - 0.036 14.4 1.1 0.036 14.4 1.1 1.9 2 0 0 2 2 2 0 Large-conductance mechanosensitive channel, MscL Chordopox_A13L PF05961.11 EKX72282.1 - 0.044 14.0 0.1 0.24 11.7 0.0 2.2 2 0 0 2 2 2 0 Chordopoxvirus A13L protein FAINT PF04385.15 EKX72284.1 - 4.6e-05 23.4 0.0 0.0001 22.3 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function, DUF529 DUF4428 PF14471.6 EKX72285.1 - 0.0047 16.8 0.1 0.017 15.0 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4428) DUF4762 PF15959.5 EKX72285.1 - 0.4 10.7 4.5 0.18 11.8 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4762) FAINT PF04385.15 EKX72286.1 - 1.8e-05 24.7 0.1 1.8e-05 24.7 0.1 2.2 2 1 1 3 3 3 1 Domain of unknown function, DUF529 STI1 PF17830.1 EKX72287.1 - 0.13 12.3 0.0 0.56 10.2 0.0 1.9 2 0 0 2 2 2 0 STI1 domain Rhodanese_C PF12368.8 EKX72287.1 - 0.23 11.9 8.2 0.39 11.1 8.2 1.4 1 0 0 1 1 1 0 Rhodanase C-terminal zf-HIT PF04438.16 EKX72287.1 - 2 8.3 12.7 0.29 11.0 9.1 1.5 2 0 0 2 2 2 0 HIT zinc finger Sugar_tr PF00083.24 EKX72291.1 - 1.3e-59 202.3 34.6 1.6e-59 202.0 34.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EKX72291.1 - 1.1e-11 44.3 38.1 1e-07 31.2 15.9 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EKX72291.1 - 4.7e-05 22.0 2.2 4.7e-05 22.0 2.2 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) CYYR1 PF10873.8 EKX72291.1 - 7.1 7.1 8.9 0.23 11.9 1.9 2.1 2 1 0 2 2 2 0 Cysteine and tyrosine-rich protein 1 HABP4_PAI-RBP1 PF04774.15 EKX72293.1 - 0.12 13.2 12.9 0.21 12.5 12.9 1.3 1 0 0 1 1 1 0 Hyaluronan / mRNA binding family PBP_sp32 PF07222.12 EKX72293.1 - 0.58 9.6 3.5 0.85 9.0 3.5 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 TRAP_alpha PF03896.16 EKX72293.1 - 1.5 8.0 6.2 2.2 7.4 6.2 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF5089 PF17002.5 EKX72293.1 - 1.7 8.5 10.9 2.8 7.8 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF5089) PRTP PF01366.18 EKX72293.1 - 3.9 5.4 6.1 0.94 7.4 1.6 1.8 2 0 0 2 2 2 0 Herpesvirus processing and transport protein Nop14 PF04147.12 EKX72293.1 - 4 5.5 16.1 5.1 5.2 16.1 1.0 1 0 0 1 1 1 0 Nop14-like family DUF2457 PF10446.9 EKX72293.1 - 9.3 5.3 16.8 12 4.9 16.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF2407_C PF13373.6 EKX72295.1 - 0.014 15.6 0.0 0.039 14.1 0.0 1.8 2 0 0 2 2 2 0 DUF2407 C-terminal domain Retrotrans_gag PF03732.17 EKX72298.1 - 0.21 11.9 2.7 20 5.6 0.1 4.0 4 0 0 4 4 4 0 Retrotransposon gag protein FAINT PF04385.15 EKX72303.1 - 1.7e-11 44.0 0.3 8e-07 29.0 0.1 2.6 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Baculo_PEP_C PF04513.12 EKX72304.1 - 0.0062 16.6 5.5 0.14 12.2 1.6 3.1 3 1 1 4 4 4 1 Baculovirus polyhedron envelope protein, PEP, C terminus CENP-F_leu_zip PF10473.9 EKX72304.1 - 0.0076 16.3 0.0 0.022 14.8 0.0 1.7 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TBCC_N PF16752.5 EKX72304.1 - 0.073 13.5 0.5 0.073 13.5 0.5 3.2 4 1 0 4 4 4 0 Tubulin-specific chaperone C N-terminal domain DUF4547 PF15080.6 EKX72304.1 - 0.1 12.2 1.1 6.5 6.3 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4547) BAR_3 PF16746.5 EKX72304.1 - 0.12 12.1 0.9 1.4 8.6 0.0 2.4 2 1 0 2 2 2 0 BAR domain of APPL family BLOC1_2 PF10046.9 EKX72304.1 - 0.21 11.9 2.3 0.7 10.2 0.1 2.8 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SKA2 PF16740.5 EKX72304.1 - 0.28 11.0 2.0 28 4.5 0.0 3.9 5 0 0 5 5 5 0 Spindle and kinetochore-associated protein 2 PIN_8 PF18476.1 EKX72304.1 - 0.31 10.9 6.9 3.3 7.5 2.4 2.7 1 1 2 3 3 3 0 PIN like domain MAD PF05557.13 EKX72304.1 - 0.44 8.9 3.8 3.2 6.0 0.7 2.3 2 1 0 2 2 2 0 Mitotic checkpoint protein PspA_IM30 PF04012.12 EKX72304.1 - 1.1 8.8 9.6 0.4 10.2 5.7 2.1 2 0 0 2 2 2 0 PspA/IM30 family E1_dh PF00676.20 EKX72305.1 - 2.3e-52 177.8 0.0 3.4e-52 177.2 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component Transket_pyr PF02779.24 EKX72305.1 - 4.1e-51 173.2 0.0 8.3e-51 172.2 0.0 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 EKX72305.1 - 3.2e-44 150.3 0.0 5.8e-44 149.4 0.0 1.5 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 EKX72305.1 - 6.1e-08 32.1 0.5 1.6e-07 30.8 0.5 1.7 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase N-terminus TFIIS_M PF07500.14 EKX72306.1 - 1.3e-14 54.7 0.3 1.3e-14 54.7 0.3 2.0 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain BUD22 PF09073.10 EKX72306.1 - 0.15 11.3 10.0 0.19 11.1 10.0 1.2 1 0 0 1 1 1 0 BUD22 FAM104 PF15434.6 EKX72306.1 - 0.74 10.4 8.0 1.8 9.2 8.0 1.6 1 0 0 1 1 1 0 Family 104 CDC45 PF02724.14 EKX72306.1 - 4.1 5.6 9.4 5.9 5.0 9.4 1.2 1 0 0 1 1 1 0 CDC45-like protein Peptidase_S41 PF03572.18 EKX72309.1 - 0.098 12.2 0.0 0.63 9.6 0.0 2.3 3 0 0 3 3 3 0 Peptidase family S41 DUF4852 PF16144.5 EKX72310.1 - 0.028 14.5 0.5 0.096 12.8 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4852) IpaB_EvcA PF03278.13 EKX72310.1 - 0.034 13.8 0.0 0.12 12.1 0.0 1.9 2 0 0 2 2 2 0 IpaB/EvcA family RNA_pol_Rpc4 PF05132.14 EKX72312.1 - 0.77 10.2 8.0 1.6 9.2 8.0 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 Zip PF02535.22 EKX72312.1 - 2.7 7.1 4.3 4.3 6.5 4.3 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter TBP-binding PF09247.11 EKX72312.1 - 3.4 8.0 5.8 9.2 6.6 0.2 2.5 2 0 0 2 2 2 0 TATA box-binding protein binding FAINT PF04385.15 EKX72313.1 - 8.5e-06 25.7 1.1 0.16 12.0 0.2 2.8 3 0 0 3 3 3 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72314.1 - 7.2e-06 26.0 0.3 0.00056 19.9 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 DUF903 PF06004.12 EKX72315.1 - 2.3 8.2 5.6 0.47 10.4 0.2 2.8 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF903) Vasculin PF15337.6 EKX72315.1 - 5.2 8.0 6.2 43 5.0 0.0 3.6 4 0 0 4 4 4 0 Vascular protein family Vasculin-like 1 FAINT PF04385.15 EKX72316.1 - 1.7e-13 50.4 2.3 1.2e-05 25.3 0.0 3.9 4 0 0 4 4 4 3 Domain of unknown function, DUF529 SNF2_N PF00176.23 EKX72317.1 - 1.4e-54 185.1 0.2 4.4e-54 183.5 0.2 1.8 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EKX72317.1 - 2.5e-20 72.9 1.1 2.3e-19 69.7 0.0 3.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Bromodomain PF00439.25 EKX72317.1 - 4.9e-12 45.7 0.1 3e-11 43.2 0.1 2.4 1 0 0 1 1 1 1 Bromodomain ResIII PF04851.15 EKX72317.1 - 1.2e-11 45.0 0.0 7.4e-10 39.1 0.0 3.7 5 0 0 5 5 5 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EKX72317.1 - 0.00054 19.8 0.0 0.002 17.9 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EKX72317.1 - 0.0059 16.3 0.0 0.019 14.7 0.0 1.8 1 0 0 1 1 1 1 SWI2/SNF2 ATPase DUF4355 PF14265.6 EKX72317.1 - 2.1 8.6 10.2 0.47 10.7 4.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) FAINT PF04385.15 EKX72318.1 - 1.2e-06 28.5 0.0 1.6e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function, DUF529 CRAL_TRIO PF00650.20 EKX72319.1 - 2.1e-35 121.8 0.2 3e-35 121.3 0.2 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EKX72319.1 - 3.4e-07 30.5 0.1 5.8e-07 29.8 0.1 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain FAINT PF04385.15 EKX72320.1 - 0.0014 18.7 0.4 0.0033 17.5 0.3 1.8 1 1 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72321.1 - 0.001 19.1 0.0 0.0019 18.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 Snf7 PF03357.21 EKX72322.1 - 1.1e-26 93.5 12.2 1.3e-26 93.2 12.2 1.1 1 0 0 1 1 1 1 Snf7 NPV_P10 PF05531.12 EKX72322.1 - 0.008 16.6 2.9 0.16 12.5 0.7 2.6 3 0 0 3 3 3 1 Nucleopolyhedrovirus P10 protein UBD PF16455.5 EKX72322.1 - 0.015 15.5 0.4 0.028 14.7 0.4 1.4 1 0 0 1 1 1 0 Ubiquitin-binding domain BST2 PF16716.5 EKX72322.1 - 0.02 15.5 4.1 0.02 15.5 4.1 2.5 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 DUF2362 PF10154.9 EKX72322.1 - 0.069 12.1 4.7 0.085 11.8 4.7 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2362) YojJ PF10372.9 EKX72322.1 - 0.077 13.1 0.2 2.6 8.2 0.3 2.4 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus YgaB PF14182.6 EKX72322.1 - 0.089 13.2 3.8 1.6 9.2 1.1 2.7 1 1 1 2 2 2 0 YgaB-like protein Tropomyosin_1 PF12718.7 EKX72322.1 - 0.31 11.2 0.1 0.31 11.2 0.1 2.3 2 1 0 2 2 2 0 Tropomyosin like TMPIT PF07851.13 EKX72322.1 - 0.78 8.9 8.5 1.1 8.5 6.4 1.9 1 1 1 2 2 2 0 TMPIT-like protein DUF3138 PF11336.8 EKX72322.1 - 1.4 7.4 4.9 1.8 7.1 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) ABC_tran_Xtn PF12848.7 EKX72322.1 - 4.8 7.3 8.1 3.2 7.9 3.7 2.2 1 1 1 2 2 2 0 ABC transporter DUF848 PF05852.11 EKX72322.1 - 5.2 7.2 7.9 2.6 8.1 4.2 2.1 1 1 1 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) Evr1_Alr PF04777.13 EKX72324.1 - 8.5e-06 26.2 0.2 1.1e-05 25.8 0.2 1.2 1 0 0 1 1 1 1 Erv1 / Alr family GBP_repeat PF02526.14 EKX72324.1 - 0.12 12.1 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Glycophorin-binding protein MMR_HSR1 PF01926.23 EKX72325.1 - 1e-14 54.6 0.0 2.1e-14 53.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EKX72325.1 - 5.7e-05 22.7 0.0 0.00014 21.4 0.0 1.8 2 1 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EKX72325.1 - 0.0036 16.9 0.0 0.0096 15.5 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Sial-lect-inser PF09264.10 EKX72325.1 - 0.049 13.4 0.2 0.096 12.4 0.2 1.4 1 0 0 1 1 1 0 Vibrio cholerae sialidase, lectin insertion RsgA_GTPase PF03193.16 EKX72325.1 - 0.095 12.6 0.0 0.53 10.2 0.0 2.2 3 0 0 3 3 3 0 RsgA GTPase FAINT PF04385.15 EKX72327.1 - 4.6e-13 49.0 0.2 0.012 15.6 0.0 4.7 4 1 0 4 4 4 4 Domain of unknown function, DUF529 CBF_beta PF02312.17 EKX72327.1 - 0.16 11.6 0.0 1.2 8.7 0.0 2.1 2 0 0 2 2 2 0 Core binding factor beta subunit VSG_B PF13206.6 EKX72328.1 - 0.0074 15.6 10.9 0.012 14.9 10.6 1.5 2 0 0 2 2 2 1 Trypanosomal VSG domain PaREP1 PF05942.11 EKX72328.1 - 0.013 15.4 5.4 0.013 15.4 5.4 1.7 1 1 1 2 2 2 0 Archaeal PaREP1/PaREP8 family DUF3539 PF12058.8 EKX72328.1 - 0.029 14.5 2.4 6 7.1 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3539) Mit_ribos_Mrp51 PF11709.8 EKX72328.1 - 0.12 11.9 5.8 0.14 11.7 5.8 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit Cytochrom_C_2 PF01322.20 EKX72328.1 - 0.15 12.9 4.9 0.25 12.2 4.9 1.3 1 0 0 1 1 1 0 Cytochrome C' PTRF_SDPR PF15237.6 EKX72328.1 - 0.17 11.5 11.7 0.24 11.0 11.7 1.3 1 0 0 1 1 1 0 PTRF/SDPR family YojJ PF10372.9 EKX72328.1 - 6.9 6.9 6.9 0.86 9.7 2.1 2.0 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus Ndufs5 PF10200.9 EKX72328.1 - 6.9 7.0 7.6 26 5.2 3.2 2.7 1 1 1 2 2 2 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa DUF4446 PF14584.6 EKX72328.1 - 7.1 6.6 11.5 3.9 7.5 5.0 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF4446) PFL-like PF02901.15 EKX72329.1 - 0.061 11.9 3.6 0.078 11.6 3.6 1.1 1 0 0 1 1 1 0 Pyruvate formate lyase-like DUF4407 PF14362.6 EKX72329.1 - 0.077 12.3 1.3 0.098 12.0 1.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF463 PF04317.12 EKX72329.1 - 0.16 10.8 1.1 0.23 10.4 1.1 1.1 1 0 0 1 1 1 0 YcjX-like family, DUF463 Seryl_tRNA_N PF02403.22 EKX72329.1 - 0.19 12.0 12.1 0.35 11.1 12.1 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF1664 PF07889.12 EKX72329.1 - 0.5 10.4 4.2 0.95 9.5 4.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Holin_BhlA PF10960.8 EKX72329.1 - 7 6.7 8.4 8.7 6.4 5.7 2.2 2 0 0 2 2 2 0 BhlA holin family GST_C PF00043.25 EKX72330.1 - 0.0026 17.9 0.0 0.0043 17.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EKX72330.1 - 0.024 14.8 0.0 0.059 13.6 0.0 1.7 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain tRNA-synt_1g PF09334.11 EKX72331.1 - 9.8e-95 317.6 0.6 4.5e-52 177.1 0.0 2.3 1 1 1 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EKX72331.1 - 5.2e-29 101.0 1.2 2.6e-14 52.4 0.2 3.2 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EKX72331.1 - 2.5e-11 43.5 0.0 0.00011 21.7 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 EKX72331.1 - 0.00038 19.5 0.0 0.008 15.1 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (K) NT-C2 PF10358.9 EKX72333.1 - 0.011 15.4 0.2 0.015 15.0 0.2 1.2 1 0 0 1 1 1 0 N-terminal C2 in EEIG1 and EHBP1 proteins FAINT PF04385.15 EKX72334.1 - 2.6e-34 117.1 1.4 2.6e-08 33.8 0.0 6.9 6 1 1 7 7 7 6 Domain of unknown function, DUF529 DUF1517 PF07466.11 EKX72334.1 - 0.95 9.6 9.5 0.59 10.2 2.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1517) Sec2p PF06428.11 EKX72335.1 - 0.83 9.7 6.9 25 4.9 4.0 2.8 2 1 1 3 3 3 0 GDP/GTP exchange factor Sec2p THOC7 PF05615.13 EKX72335.1 - 3.2 8.0 9.5 0.15 12.3 3.1 2.0 3 0 0 3 3 3 0 Tho complex subunit 7 Pkinase PF00069.25 EKX72336.1 - 1.2e-62 211.6 0.0 5.5e-62 209.5 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKX72336.1 - 1.4e-30 106.5 0.0 2.9e-21 75.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EKX72336.1 - 2.1e-06 26.9 0.3 8.9e-06 24.9 0.3 2.0 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EKX72336.1 - 0.00049 19.5 0.0 0.0012 18.2 0.0 1.6 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EKX72336.1 - 0.011 15.7 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family FAINT PF04385.15 EKX72337.1 - 1e-33 115.2 19.9 1.2e-05 25.3 1.1 6.6 6 1 0 6 6 6 6 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72338.1 - 2.5e-16 59.5 0.1 8.3e-05 22.6 0.0 4.6 4 0 0 4 4 4 4 Domain of unknown function, DUF529 Occludin_ELL PF07303.13 EKX72338.1 - 0.01 16.6 1.1 7.9 7.3 0.2 3.0 3 0 0 3 3 3 0 Occludin homology domain Ribosomal_L37ae PF01780.19 EKX72341.1 - 0.059 13.5 1.6 0.13 12.3 1.6 1.5 1 0 0 1 1 1 0 Ribosomal L37ae protein family DNA_gyraseB PF00204.25 EKX72341.1 - 0.13 11.8 0.1 0.24 10.8 0.1 1.4 1 0 0 1 1 1 0 DNA gyrase B FAINT PF04385.15 EKX72342.1 - 3.9e-10 39.7 0.8 9.3e-06 25.6 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72343.1 - 4.3e-06 26.7 2.0 0.03 14.4 0.2 2.3 2 0 0 2 2 2 2 Domain of unknown function, DUF529 BCLP PF12304.8 EKX72343.1 - 0.069 12.7 0.4 0.11 12.0 0.4 1.3 1 0 0 1 1 1 0 Beta-casein like protein Arm PF00514.23 EKX72344.1 - 3.3e-05 23.8 0.0 0.00044 20.2 0.0 2.6 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat HEAT PF02985.22 EKX72344.1 - 0.11 12.8 0.0 5.2 7.6 0.0 2.9 2 0 0 2 2 2 0 HEAT repeat Hydrolase_3 PF08282.12 EKX72345.1 - 9.8e-33 114.0 0.0 1.3e-32 113.5 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EKX72345.1 - 0.00021 20.9 0.0 0.0044 16.6 0.0 2.1 2 0 0 2 2 2 1 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EKX72345.1 - 0.02 15.2 0.0 1 9.6 0.0 2.7 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EKX72345.1 - 0.1 12.7 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase ArsA_ATPase PF02374.15 EKX72346.1 - 1.3e-53 182.1 5.6 4.4e-44 150.9 0.9 2.0 1 1 1 2 2 2 2 Anion-transporting ATPase DUF4924 PF16271.5 EKX72346.1 - 9.3e-05 22.5 1.0 0.00033 20.7 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4924) Cor1 PF04803.12 EKX72346.1 - 0.0025 18.0 2.4 0.0027 17.9 0.4 1.9 2 0 0 2 2 2 1 Cor1/Xlr/Xmr conserved region RMI1_N PF08585.12 EKX72346.1 - 0.036 13.8 0.1 0.051 13.3 0.1 1.2 1 0 0 1 1 1 0 RecQ mediated genome instability protein Mod_r PF07200.13 EKX72346.1 - 0.044 13.9 1.1 0.2 11.7 0.1 2.2 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein ArsA_ATPase PF02374.15 EKX72347.1 - 1.8e-09 37.2 0.3 3.1e-09 36.5 0.3 1.3 1 0 0 1 1 1 1 Anion-transporting ATPase CbiA PF01656.23 EKX72347.1 - 2e-06 27.9 0.1 5.1e-06 26.6 0.1 1.6 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 EKX72347.1 - 0.0016 18.0 0.1 0.0028 17.1 0.1 1.3 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase AAA_31 PF13614.6 EKX72347.1 - 0.0017 18.3 0.0 0.0034 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EKX72347.1 - 0.0064 15.7 0.0 0.056 12.6 0.0 2.2 2 0 0 2 2 2 1 NB-ARC domain AAA_18 PF13238.6 EKX72347.1 - 0.012 16.1 0.3 0.056 14.0 0.0 2.3 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 EKX72347.1 - 0.057 13.8 0.1 0.28 11.6 0.0 2.3 2 0 0 2 2 2 0 RNA helicase PRK PF00485.18 EKX72347.1 - 0.07 12.9 0.0 0.22 11.2 0.0 1.8 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family NACHT PF05729.12 EKX72347.1 - 0.071 13.0 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_25 PF13481.6 EKX72347.1 - 0.18 11.3 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain MFAP1 PF06991.11 EKX72348.1 - 0.016 15.0 2.2 0.046 13.6 0.2 2.1 2 0 0 2 2 2 0 Microfibril-associated/Pre-mRNA processing FAINT PF04385.15 EKX72351.1 - 0.00018 21.5 0.7 0.00044 20.3 0.1 1.9 1 1 1 2 2 2 1 Domain of unknown function, DUF529 Topo_Zn_Ribbon PF08272.11 EKX72351.1 - 0.1 12.3 0.2 0.25 11.0 0.0 1.8 2 0 0 2 2 2 0 Topoisomerase I zinc-ribbon-like MscL PF01741.18 EKX72352.1 - 0.083 13.2 1.4 0.19 12.1 1.4 1.6 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL FAINT PF04385.15 EKX72354.1 - 1.7e-06 28.0 0.0 0.016 15.2 0.0 4.1 4 0 0 4 4 4 3 Domain of unknown function, DUF529 HMG_box PF00505.19 EKX72354.1 - 0.2 12.1 1.7 0.77 10.2 1.0 2.3 2 0 0 2 2 2 0 HMG (high mobility group) box FAINT PF04385.15 EKX72357.1 - 1.3e-12 47.6 2.6 0.0031 17.5 0.6 3.5 3 0 0 3 3 3 3 Domain of unknown function, DUF529 Aquarius_N PF16399.5 EKX72358.1 - 8.4e-133 444.2 5.1 2.7e-132 442.5 5.1 1.6 1 1 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_11 PF13086.6 EKX72358.1 - 6e-31 108.2 0.0 3.4e-15 56.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_12 PF13087.6 EKX72358.1 - 4.3e-26 91.8 0.0 1.6e-25 89.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EKX72358.1 - 2.1e-07 31.4 0.0 9.6e-07 29.2 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EKX72358.1 - 7e-07 29.2 0.0 0.0029 17.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain UvrD_C_2 PF13538.6 EKX72358.1 - 0.00016 21.4 0.0 0.00043 20.1 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_16 PF13191.6 EKX72358.1 - 0.0014 19.1 0.1 0.02 15.3 0.0 2.8 3 0 0 3 3 3 1 AAA ATPase domain UvrD-helicase PF00580.21 EKX72358.1 - 0.0056 16.3 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 EKX72358.1 - 0.026 14.3 0.1 2 8.1 0.0 3.2 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase AAA_5 PF07728.14 EKX72358.1 - 0.028 14.4 0.0 0.19 11.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA PF00004.29 EKX72358.1 - 0.048 14.1 0.0 0.12 12.8 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EKX72358.1 - 0.076 13.4 0.0 6.6 7.2 0.0 2.9 2 1 0 2 2 2 0 RNA helicase AAA_22 PF13401.6 EKX72358.1 - 0.12 12.6 0.0 0.43 10.8 0.0 2.0 1 0 0 1 1 1 0 AAA domain FAINT PF04385.15 EKX72359.1 - 8.9e-28 96.2 6.6 2.3e-09 37.2 0.0 4.4 4 0 0 4 4 4 4 Domain of unknown function, DUF529 Adeno_E3_CR2 PF02439.15 EKX72360.1 - 0.039 13.7 2.6 0.075 12.8 2.6 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 zf-piccolo PF05715.13 EKX72360.1 - 0.063 13.4 2.1 0.12 12.5 2.1 1.5 1 0 0 1 1 1 0 Piccolo Zn-finger Glycophorin_A PF01102.18 EKX72360.1 - 0.066 13.4 2.4 0.079 13.2 0.3 2.2 2 1 0 2 2 2 0 Glycophorin A Mucin PF01456.17 EKX72360.1 - 2.2 8.3 14.1 0.14 12.1 8.3 1.9 2 0 0 2 2 2 0 Mucin-like glycoprotein IFT57 PF10498.9 EKX72362.1 - 0.0094 15.0 0.8 0.015 14.3 0.8 1.2 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 ERbeta_N PF12497.8 EKX72362.1 - 0.047 13.5 1.8 1.3 8.9 0.6 2.4 2 0 0 2 2 2 0 Estrogen receptor beta RRM_occluded PF16842.5 EKX72362.1 - 0.054 13.4 0.0 0.22 11.4 0.0 1.9 2 0 0 2 2 2 0 Occluded RNA-recognition motif Synaptobrevin PF00957.21 EKX72363.1 - 3.1e-11 42.9 0.2 5.6e-11 42.1 0.2 1.4 1 0 0 1 1 1 1 Synaptobrevin Adaptin_N PF01602.20 EKX72364.1 - 1.7e-26 92.9 0.0 2.1e-26 92.6 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region DUF4313 PF14190.6 EKX72365.1 - 0.015 15.3 0.0 0.17 11.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4313) TAF4 PF05236.14 EKX72365.1 - 0.18 11.5 0.1 0.3 10.8 0.1 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Adaptin_N PF01602.20 EKX72366.1 - 1.7e-11 43.4 0.3 2.3e-11 43.0 0.3 1.1 1 0 0 1 1 1 1 Adaptin N terminal region BT1 PF03092.16 EKX72367.1 - 1.2e-49 169.0 21.0 1.4e-33 115.9 8.1 2.0 2 0 0 2 2 2 2 BT1 family FAINT PF04385.15 EKX72368.1 - 2.1e-12 46.9 0.0 1.2e-05 25.3 0.0 3.7 3 0 0 3 3 3 3 Domain of unknown function, DUF529 EMA PF02488.15 EKX72368.1 - 0.05 13.3 0.9 0.11 12.1 0.1 2.0 2 0 0 2 2 2 0 Merozoite Antigen PLL PF18587.1 EKX72370.1 - 0.0041 17.2 0.0 0.038 14.1 0.1 2.2 2 0 0 2 2 2 1 PTX/LNS-Like (PLL) domain Vfa1 PF08432.10 EKX72370.1 - 1.1 9.5 7.5 2.1 8.6 7.5 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF3073 PF11273.8 EKX72370.1 - 3 8.7 5.7 8.7 7.2 5.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3073) FANCI_S2 PF14676.6 EKX72371.1 - 3.1 8.1 8.9 1.8 8.9 2.7 2.9 2 2 0 2 2 2 0 FANCI solenoid 2 MobC PF05713.11 EKX72371.1 - 7.4 7.1 7.9 16 6.0 0.1 4.1 4 0 0 4 4 4 0 Bacterial mobilisation protein (MobC) Hydrolase_3 PF08282.12 EKX72372.1 - 1e-26 94.2 0.0 6.3e-16 58.9 0.0 2.1 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EKX72372.1 - 0.0092 16.3 0.0 3.4 7.9 0.0 2.5 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EKX72372.1 - 0.071 13.5 0.0 3.6 7.9 0.0 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase FAINT PF04385.15 EKX72373.1 - 3.8e-39 132.6 24.8 2.5e-05 24.2 0.1 11.0 11 0 0 11 11 11 10 Domain of unknown function, DUF529 TMEM214 PF10151.9 EKX72374.1 - 0.24 9.8 0.2 0.47 8.8 0.2 1.5 1 1 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator PRA-CH PF01502.18 EKX72376.1 - 0.0062 16.3 0.6 0.29 11.0 0.1 3.0 2 0 0 2 2 2 1 Phosphoribosyl-AMP cyclohydrolase BNR_6 PF15899.5 EKX72376.1 - 0.065 13.3 0.6 0.24 11.5 0.6 2.0 1 0 0 1 1 1 0 BNR-Asp box repeat HECW1_helix PF18436.1 EKX72376.1 - 0.12 12.5 0.0 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 Helical box domain of E3 ubiquitin-protein ligase HECW1 Adeno_E3_CR1 PF02440.15 EKX72376.1 - 1.1 9.1 7.3 5.1 7.0 0.3 4.4 3 0 0 3 3 3 0 Adenovirus E3 region protein CR1 AF-4 PF05110.13 EKX72376.1 - 1.1 7.3 8.7 1.8 6.5 8.7 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein FAINT PF04385.15 EKX72377.1 - 1.1e-25 89.4 4.0 1.4e-07 31.5 0.0 4.5 4 0 0 4 4 4 4 Domain of unknown function, DUF529 p31comet PF06581.12 EKX72378.1 - 0.0053 16.0 0.0 0.0063 15.7 0.0 1.0 1 0 0 1 1 1 1 Mad1 and Cdc20-bound-Mad2 binding RRM_3 PF08777.11 EKX72378.1 - 0.025 14.6 0.0 0.028 14.4 0.0 1.2 1 0 0 1 1 1 0 RNA binding motif Histone PF00125.24 EKX72379.1 - 5.1e-15 56.0 0.0 6.8e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EKX72379.1 - 1.1e-11 44.2 0.0 2.2e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 EKX72379.1 - 0.039 14.2 0.0 0.066 13.5 0.0 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone RHH_4 PF13467.6 EKX72380.1 - 0.049 13.5 0.0 0.15 12.0 0.0 1.8 1 0 0 1 1 1 0 Ribbon-helix-helix domain Treacle PF03546.14 EKX72381.1 - 0.00068 18.6 2.5 0.00082 18.3 2.5 1.1 1 0 0 1 1 1 1 Treacher Collins syndrome protein Treacle DUF1672 PF07901.11 EKX72381.1 - 0.1 11.9 0.8 0.13 11.5 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1672) Tub_N PF16322.5 EKX72381.1 - 0.19 12.1 8.2 0.27 11.6 8.2 1.3 1 0 0 1 1 1 0 Tubby N-terminal TFIIF_alpha PF05793.12 EKX72381.1 - 0.71 8.4 9.3 0.89 8.1 9.3 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SPX PF03105.19 EKX72381.1 - 0.98 9.3 7.0 1.2 9.0 7.0 1.1 1 0 0 1 1 1 0 SPX domain Hydrolase_3 PF08282.12 EKX72382.1 - 1.8e-39 136.0 0.1 2.2e-39 135.8 0.1 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EKX72382.1 - 2.2e-06 27.4 0.0 0.027 14.0 0.0 2.2 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase DUF3799 PF12684.7 EKX72382.1 - 0.019 14.7 0.0 0.076 12.8 0.0 2.0 3 0 0 3 3 3 0 PDDEXK-like domain of unknown function (DUF3799) BofC_C PF08955.10 EKX72382.1 - 0.063 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 BofC C-terminal domain TUSC2 PF15000.6 EKX72382.1 - 0.078 13.3 0.6 0.69 10.2 0.1 2.1 2 0 0 2 2 2 0 Tumour suppressor candidate 2 Sugar_tr PF00083.24 EKX72385.1 - 7.9e-56 189.8 32.8 1e-55 189.4 32.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EKX72385.1 - 4.1e-12 45.7 27.3 4.1e-12 45.7 27.3 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EKX72385.1 - 1.5e-05 23.6 2.9 3.3e-05 22.5 2.9 1.5 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Pes-10 PF07149.11 EKX72385.1 - 0.16 11.0 0.0 0.23 10.5 0.0 1.1 1 0 0 1 1 1 0 Pes-10 FAINT PF04385.15 EKX72386.1 - 6.3e-16 58.2 0.0 7.4e-09 35.6 0.0 3.5 3 0 0 3 3 3 3 Domain of unknown function, DUF529 MIOX PF05153.15 EKX72387.1 - 0.0066 16.0 0.0 0.01 15.4 0.0 1.3 1 0 0 1 1 1 1 Myo-inositol oxygenase DUF521 PF04412.13 EKX72387.1 - 0.22 10.2 0.0 0.3 9.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF521) 14-3-3 PF00244.20 EKX72389.1 - 0.066 12.7 0.0 0.079 12.5 0.0 1.0 1 0 0 1 1 1 0 14-3-3 protein FAINT PF04385.15 EKX72391.1 - 1.2e-29 102.2 13.4 2.7e-06 27.3 0.0 7.2 7 0 0 7 7 7 6 Domain of unknown function, DUF529 DUF3883 PF13020.6 EKX72393.1 - 0.0051 16.8 0.2 1.3 9.1 0.0 3.0 1 1 2 3 3 3 2 Domain of unknown function (DUF3883) DUF1365 PF07103.11 EKX72393.1 - 0.095 12.4 0.1 0.17 11.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1365) FAINT PF04385.15 EKX72394.1 - 2.5e-09 37.1 0.0 0.00051 20.0 0.0 3.5 3 0 0 3 3 3 3 Domain of unknown function, DUF529 AP2 PF00847.20 EKX72395.1 - 0.095 13.0 0.4 0.15 12.3 0.4 1.3 1 0 0 1 1 1 0 AP2 domain Bd3614-deam PF14439.6 EKX72395.1 - 1.2 9.2 5.7 1.9 8.6 5.7 1.5 1 1 0 1 1 1 0 Bd3614-like deaminase NOA36 PF06524.12 EKX72395.1 - 1.2 8.4 7.4 1.4 8.1 7.4 1.1 1 0 0 1 1 1 0 NOA36 protein PPP4R2 PF09184.11 EKX72395.1 - 3.1 7.3 8.0 3.7 7.1 8.0 1.1 1 0 0 1 1 1 0 PPP4R2 CENP-B_dimeris PF09026.10 EKX72395.1 - 6.3 7.2 14.1 9.6 6.7 14.1 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain CDC45 PF02724.14 EKX72395.1 - 6.5 4.9 6.7 7.5 4.7 6.7 1.0 1 0 0 1 1 1 0 CDC45-like protein BT1 PF03092.16 EKX72396.1 - 2.3e-46 158.1 27.0 9.7e-35 119.8 10.4 2.0 2 0 0 2 2 2 2 BT1 family MFS_1 PF07690.16 EKX72396.1 - 1.5e-06 27.4 20.0 1.5e-06 27.4 20.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily FAINT PF04385.15 EKX72397.1 - 1.6e-08 34.5 0.1 0.00016 21.6 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function, DUF529 DR2241 PF18069.1 EKX72397.1 - 0.25 11.2 1.2 0.49 10.3 0.3 1.9 2 0 0 2 2 2 0 DR2241 stabilising domain DUF4887 PF16228.5 EKX72399.1 - 0.0074 16.5 12.7 0.013 15.7 12.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4887) FAINT PF04385.15 EKX72399.1 - 0.029 14.4 0.0 1.4 9.1 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function, DUF529 DUF2510 PF10708.9 EKX72399.1 - 0.13 12.1 0.1 0.39 10.5 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2510) FAINT PF04385.15 EKX72400.1 - 4.3e-12 45.9 0.6 4.3e-12 45.9 0.6 1.4 2 0 0 2 2 2 1 Domain of unknown function, DUF529 CG-1 PF03859.16 EKX72400.1 - 0.055 13.3 0.1 0.09 12.6 0.1 1.3 1 0 0 1 1 1 0 CG-1 domain FAINT PF04385.15 EKX72401.1 - 0.0012 18.9 0.1 0.0018 18.3 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72402.1 - 0.089 12.9 0.6 0.6 10.2 0.1 2.4 2 1 0 2 2 2 0 Domain of unknown function, DUF529 Hydrolase_4 PF12146.8 EKX72403.1 - 5.6e-22 78.2 0.0 2.6e-21 76.0 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX72403.1 - 6.2e-09 35.8 6.8 1.6e-05 24.8 0.0 3.8 4 0 0 4 4 4 2 Domain of unknown function, DUF529 Abhydrolase_1 PF00561.20 EKX72403.1 - 1.3e-05 25.0 0.0 3.9e-05 23.4 0.0 1.8 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EKX72403.1 - 0.0029 18.2 0.0 0.0085 16.7 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EKX72403.1 - 0.03 13.8 0.4 1.2 8.6 0.1 2.9 3 0 0 3 3 3 0 Prolyl oligopeptidase family ATPase-cat_bd PF12156.8 EKX72404.1 - 0.14 12.9 0.0 0.3 11.9 0.0 1.5 1 0 0 1 1 1 0 Putative metal-binding domain of cation transport ATPase SRP1_TIP1 PF00660.17 EKX72407.1 - 0.0051 16.9 0.3 0.047 13.8 0.0 2.5 3 0 0 3 3 3 1 Seripauperin and TIP1 family YejG PF13989.6 EKX72407.1 - 0.032 14.7 0.0 0.093 13.2 0.0 1.8 1 0 0 1 1 1 0 YejG-like protein MRJP PF03022.16 EKX72407.1 - 0.055 12.8 0.1 0.086 12.2 0.1 1.2 1 0 0 1 1 1 0 Major royal jelly protein FAINT PF04385.15 EKX72408.1 - 1.4e-15 57.1 0.5 4.3e-07 29.9 0.3 3.3 3 0 0 3 3 3 3 Domain of unknown function, DUF529 AhpC-TSA PF00578.21 EKX72410.1 - 0.02 14.8 0.0 0.039 13.9 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family Trans_reg_C PF00486.28 EKX72410.1 - 0.038 14.1 0.1 12 6.0 0.0 2.4 2 0 0 2 2 2 0 Transcriptional regulatory protein, C terminal BRX_N PF13713.6 EKX72410.1 - 0.048 13.4 0.2 0.1 12.4 0.2 1.5 1 0 0 1 1 1 0 Transcription factor BRX N-terminal domain T3SS_TC PF06511.11 EKX72410.1 - 0.053 12.9 0.1 0.086 12.2 0.1 1.2 1 0 0 1 1 1 0 Type III secretion systems tip complex components FAINT PF04385.15 EKX72412.1 - 6.6e-05 22.9 0.0 0.00022 21.2 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72414.1 - 6.7e-30 103.0 6.5 3.3e-08 33.5 0.1 6.1 5 1 1 6 6 6 5 Domain of unknown function, DUF529 Flavi_capsid PF01003.19 EKX72414.1 - 0.38 10.5 2.4 5.1 6.9 0.0 3.5 4 0 0 4 4 4 0 Flavivirus capsid protein C MRP-S34 PF16053.5 EKX72414.1 - 0.48 10.1 2.5 4.5 6.9 0.3 2.3 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S34 T3SS_TC PF06511.11 EKX72415.1 - 0.036 13.5 0.1 0.063 12.7 0.1 1.3 1 0 0 1 1 1 0 Type III secretion systems tip complex components PI-PLC-X PF00388.19 EKX72415.1 - 0.054 13.1 0.0 0.088 12.4 0.0 1.4 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain BNR PF02012.20 EKX72415.1 - 0.082 12.9 1.6 0.81 9.9 1.6 2.9 1 0 0 1 1 1 0 BNR/Asp-box repeat Histone PF00125.24 EKX72416.1 - 1.7e-52 177.2 2.9 1.9e-52 177.1 2.9 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EKX72416.1 - 0.00015 22.1 0.0 0.00023 21.4 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 EKX72416.1 - 0.00029 21.4 0.8 0.00035 21.2 0.8 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 EKX72416.1 - 0.00072 19.6 0.7 0.001 19.2 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EKX72416.1 - 0.006 16.8 1.0 0.0082 16.4 0.0 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EKX72416.1 - 0.011 15.8 0.2 0.018 15.1 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit FAINT PF04385.15 EKX72417.1 - 0.0025 17.9 0.0 0.0046 17.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function, DUF529 p53-inducible11 PF14936.6 EKX72418.1 - 0.15 12.1 0.6 0.33 11.0 0.2 1.6 2 0 0 2 2 2 0 Tumour protein p53-inducible protein 11 FAINT PF04385.15 EKX72420.1 - 0.0064 16.5 0.0 1.3 9.1 0.0 2.9 3 0 0 3 3 3 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72421.1 - 1.7e-21 76.1 0.0 1.9e-05 24.6 0.0 4.7 4 1 0 4 4 4 4 Domain of unknown function, DUF529 Flavi_capsid PF01003.19 EKX72421.1 - 0.23 11.2 1.1 16 5.3 0.0 2.9 3 0 0 3 3 3 0 Flavivirus capsid protein C ABC_tran PF00005.27 EKX72422.1 - 1.2e-30 106.8 0.0 5.5e-17 62.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EKX72422.1 - 2.2e-07 31.0 0.3 0.018 14.9 0.0 3.6 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EKX72422.1 - 6.6e-06 25.8 0.8 0.054 13.2 0.1 3.2 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EKX72422.1 - 2.2e-05 24.9 0.0 0.014 15.8 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 EKX72422.1 - 0.00016 21.5 0.1 0.29 10.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EKX72422.1 - 0.00064 20.3 0.1 2.4 8.7 0.0 2.9 2 0 0 2 2 2 2 AAA domain DnaB_C PF03796.15 EKX72422.1 - 0.00096 18.5 0.0 0.083 12.2 0.0 2.2 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain DUF87 PF01935.17 EKX72422.1 - 0.00098 19.3 1.4 0.041 14.0 0.0 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain RsgA_GTPase PF03193.16 EKX72422.1 - 0.0012 18.7 0.4 0.13 12.1 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase Zeta_toxin PF06414.12 EKX72422.1 - 0.0017 17.7 0.2 0.65 9.2 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_23 PF13476.6 EKX72422.1 - 0.0039 17.7 10.8 0.21 12.1 0.5 3.2 4 0 0 4 4 3 2 AAA domain MMR_HSR1 PF01926.23 EKX72422.1 - 0.0053 16.8 0.1 0.1 12.7 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase SMC_N PF02463.19 EKX72422.1 - 0.0072 15.8 0.3 0.18 11.2 0.0 2.5 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain FtsK_SpoIIIE PF01580.18 EKX72422.1 - 0.0085 15.5 0.3 1.5 8.1 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family NACHT PF05729.12 EKX72422.1 - 0.0094 15.9 0.5 3 7.8 0.1 2.5 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 EKX72422.1 - 0.011 16.0 0.1 1.6 9.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 EKX72422.1 - 0.012 14.6 0.4 0.029 13.4 0.0 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TrwB_AAD_bind PF10412.9 EKX72422.1 - 0.035 13.0 0.2 4.4 6.1 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain T2SSE PF00437.20 EKX72422.1 - 0.038 13.0 0.6 6.6 5.7 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein cobW PF02492.19 EKX72422.1 - 0.048 13.2 0.6 6.8 6.3 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 EKX72422.1 - 0.052 12.7 0.4 1.3 8.2 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain ATP_bind_1 PF03029.17 EKX72422.1 - 0.076 12.8 0.1 11 5.7 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_25 PF13481.6 EKX72422.1 - 0.08 12.5 0.0 1.8 8.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EKX72422.1 - 0.09 12.7 0.3 8 6.3 0.1 2.4 2 0 0 2 2 2 0 NTPase TsaE PF02367.17 EKX72422.1 - 0.13 12.3 0.2 3.6 7.6 0.1 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_15 PF13175.6 EKX72422.1 - 0.15 11.7 4.5 5.9 6.5 0.2 2.8 3 0 0 3 3 3 0 AAA ATPase domain IstB_IS21 PF01695.17 EKX72422.1 - 0.16 11.7 1.0 4.3 7.0 0.0 3.1 4 0 0 4 4 3 0 IstB-like ATP binding protein Dynamin_N PF00350.23 EKX72422.1 - 0.38 10.8 2.4 8.6 6.4 0.1 2.8 3 0 0 3 3 3 0 Dynamin family FAINT PF04385.15 EKX72423.1 - 9.6e-05 22.4 0.0 0.00015 21.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function, DUF529 KMP11 PF03037.16 EKX72423.1 - 0.14 12.9 1.4 0.27 12.1 0.4 1.9 2 0 0 2 2 2 0 Kinetoplastid membrane protein 11 Ndc1_Nup PF09531.10 EKX72423.1 - 3.1 6.4 7.2 4.3 5.9 7.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FAINT PF04385.15 EKX72424.1 - 0.016 15.3 0.1 0.036 14.1 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function, DUF529 ThiC_Rad_SAM PF01964.18 EKX72424.1 - 0.058 12.2 0.0 0.066 12.0 0.0 1.1 1 0 0 1 1 1 0 Radical SAM ThiC family eIF3_subunit PF08597.10 EKX72426.1 - 1.4e-11 44.8 8.9 2.4e-11 44.0 8.9 1.3 1 1 0 1 1 1 1 Translation initiation factor eIF3 subunit DIT1_PvcA PF05141.12 EKX72426.1 - 0.052 13.0 0.2 0.069 12.6 0.2 1.1 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein DUF4795 PF16043.5 EKX72426.1 - 0.11 12.0 5.8 0.29 10.7 5.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Sirohm_synth_C PF14823.6 EKX72427.1 - 0.077 12.6 0.1 0.077 12.6 0.1 2.2 3 0 0 3 3 3 0 Sirohaem biosynthesis protein C-terminal MRP-L47 PF06984.13 EKX72427.1 - 0.079 13.1 0.1 0.12 12.5 0.1 1.4 1 0 0 1 1 1 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Hydrolase_3 PF08282.12 EKX72428.1 - 3.2e-34 118.8 0.0 7.7e-34 117.6 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase GWT1 PF06423.12 EKX72428.1 - 2.7e-09 37.3 7.9 2.7e-09 37.3 7.9 2.6 2 0 0 2 2 2 1 GWT1 Hydrolase PF00702.26 EKX72428.1 - 0.00058 20.2 0.0 0.0038 17.5 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EKX72428.1 - 0.014 14.9 0.0 0.041 13.4 0.0 1.7 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase ATPase-cat_bd PF12156.8 EKX72429.1 - 0.14 12.9 0.0 0.3 11.9 0.0 1.6 1 0 0 1 1 1 0 Putative metal-binding domain of cation transport ATPase Hydrolase_4 PF12146.8 EKX72430.1 - 8.9e-22 77.5 0.0 7.3e-21 74.5 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX72430.1 - 2.9e-15 56.1 6.3 0.00025 21.0 0.7 3.6 3 0 0 3 3 3 3 Domain of unknown function, DUF529 Abhydrolase_1 PF00561.20 EKX72430.1 - 0.0077 15.9 1.9 0.018 14.7 1.1 2.1 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EKX72430.1 - 0.025 14.4 0.2 3.5 7.4 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase FAINT PF04385.15 EKX72432.1 - 8.8e-08 32.1 0.9 0.0054 16.8 0.5 2.6 2 0 0 2 2 2 2 Domain of unknown function, DUF529 DEDD_Tnp_IS110 PF01548.17 EKX72432.1 - 0.0035 17.2 0.0 0.0074 16.2 0.0 1.6 1 0 0 1 1 1 1 Transposase Pam17 PF08566.10 EKX72432.1 - 0.09 12.6 0.2 0.19 11.6 0.2 1.4 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 FAINT PF04385.15 EKX72436.1 - 2.1e-19 69.4 8.1 2.3e-08 34.0 0.5 3.9 4 0 0 4 4 4 3 Domain of unknown function, DUF529 Hydrolase_4 PF12146.8 EKX72436.1 - 4.4e-19 68.7 0.0 6e-18 65.0 0.0 2.7 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EKX72436.1 - 0.00035 21.2 0.0 0.0018 18.9 0.0 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EKX72436.1 - 0.00061 19.3 0.0 0.0035 16.9 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EKX72436.1 - 0.01 15.5 0.4 0.093 12.4 0.4 2.5 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EKX72436.1 - 0.017 14.9 0.0 3.9 7.2 0.0 2.4 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase FAINT PF04385.15 EKX72438.1 - 0.00016 21.6 0.0 0.00025 21.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 Collagen PF01391.18 EKX72439.1 - 1.4e-07 31.1 26.6 1.4e-07 31.1 26.6 3.0 3 0 0 3 3 3 1 Collagen triple helix repeat (20 copies) DUF5590 PF17881.1 EKX72439.1 - 0.18 11.9 0.5 29 4.9 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5590) Syndecan PF01034.20 EKX72440.1 - 0.39 10.7 1.0 0.96 9.4 0.3 2.0 2 0 0 2 2 2 0 Syndecan domain Choline_kinase PF01633.20 EKX72441.1 - 1.5e-38 132.5 0.0 2.4e-38 131.9 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EKX72441.1 - 2e-11 44.3 0.0 3.2e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EKX72441.1 - 0.0024 17.2 0.1 0.0041 16.5 0.1 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase CBM26 PF16738.5 EKX72442.1 - 0.024 14.9 1.9 0.055 13.7 0.3 2.3 2 0 0 2 2 2 0 Starch-binding module 26 GBR_NSP5 PF17580.2 EKX72443.1 - 0.059 13.2 0.0 0.065 13.1 0.0 1.1 1 0 0 1 1 1 0 Group B Rotavirus Non-structural protein 5 FAINT PF04385.15 EKX72444.1 - 1.3e-14 54.0 0.0 3.1e-09 36.8 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 NOG1_N PF17835.1 EKX72445.1 - 0.019 14.9 0.4 0.019 14.9 0.4 2.2 3 0 0 3 3 3 0 NOG1 N-terminal helical domain DUF1940 PF09155.10 EKX72445.1 - 0.077 13.1 0.2 0.16 12.1 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1940) Sex_peptide PF08138.11 EKX72445.1 - 0.088 13.0 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Sex peptide (SP) family Rx_N PF18052.1 EKX72445.1 - 0.09 13.1 0.5 0.09 13.1 0.5 2.4 3 0 0 3 3 3 0 Rx N-terminal domain FUSC PF04632.12 EKX72445.1 - 0.1 11.1 0.3 0.16 10.5 0.3 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Baculo_p24 PF05073.12 EKX72445.1 - 0.12 12.2 1.2 0.47 10.2 0.1 2.1 2 0 0 2 2 2 0 Baculovirus P24 capsid protein TarH PF02203.15 EKX72445.1 - 0.14 12.1 3.8 0.36 10.7 0.5 2.3 2 0 0 2 2 2 0 Tar ligand binding domain homologue ArAE_2_N PF10337.9 EKX72445.1 - 0.92 8.5 5.4 1.5 7.8 5.4 1.3 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal FAINT PF04385.15 EKX72446.1 - 0.02 14.9 0.3 0.03 14.4 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function, DUF529 Elf1 PF05129.13 EKX72448.1 - 4 7.5 5.0 59 3.8 0.0 4.2 4 0 0 4 4 4 0 Transcription elongation factor Elf1 like AAA_2 PF07724.14 EKX72449.1 - 7.2e-54 182.5 0.0 3.4e-51 173.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EKX72449.1 - 3.5e-31 107.2 6.8 5.4e-31 106.6 0.1 3.5 1 1 2 3 3 3 1 AAA lid domain ClpB_D2-small PF10431.9 EKX72449.1 - 8.8e-24 83.4 0.5 6.2e-23 80.7 0.1 2.8 3 0 0 3 3 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 EKX72449.1 - 5.5e-22 78.6 0.0 3.6e-11 43.6 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EKX72449.1 - 4.1e-16 59.2 0.0 8.3e-11 42.0 0.0 3.5 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EKX72449.1 - 1.3e-10 41.9 0.2 0.00011 22.6 0.0 3.7 2 2 1 3 3 3 2 AAA ATPase domain Sigma54_activat PF00158.26 EKX72449.1 - 1.9e-08 34.2 0.0 9.1e-06 25.5 0.0 2.6 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_22 PF13401.6 EKX72449.1 - 4.8e-08 33.4 1.8 0.083 13.2 0.1 4.7 3 2 0 3 3 3 2 AAA domain AAA_14 PF13173.6 EKX72449.1 - 1.4e-07 31.6 0.0 0.0052 16.8 0.0 3.0 2 0 0 2 2 2 2 AAA domain TniB PF05621.11 EKX72449.1 - 1.9e-07 30.7 0.6 0.0029 17.1 0.0 3.9 3 2 0 3 3 2 1 Bacterial TniB protein RuvB_N PF05496.12 EKX72449.1 - 9.8e-07 28.6 1.1 0.039 13.7 0.0 4.0 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EKX72449.1 - 1.2e-06 29.1 0.1 0.13 12.8 0.0 3.6 4 0 0 4 4 2 2 AAA domain Torsin PF06309.11 EKX72449.1 - 3.6e-05 23.9 0.0 0.00011 22.3 0.0 1.8 1 0 0 1 1 1 1 Torsin Roc PF08477.13 EKX72449.1 - 6.2e-05 23.2 0.0 0.51 10.6 0.0 2.7 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase IstB_IS21 PF01695.17 EKX72449.1 - 6.3e-05 22.8 0.0 0.33 10.7 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_7 PF12775.7 EKX72449.1 - 9.4e-05 22.0 0.0 0.083 12.4 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region RNA_helicase PF00910.22 EKX72449.1 - 0.00019 21.8 0.0 0.45 10.9 0.0 3.1 3 0 0 3 3 2 1 RNA helicase RsgA_GTPase PF03193.16 EKX72449.1 - 0.0004 20.3 0.0 0.8 9.6 0.0 2.9 2 0 0 2 2 2 2 RsgA GTPase ATPase_2 PF01637.18 EKX72449.1 - 0.00043 20.3 12.3 1.4 8.8 0.0 5.8 4 3 2 7 7 7 2 ATPase domain predominantly from Archaea Mg_chelatase PF01078.21 EKX72449.1 - 0.00046 19.6 0.0 0.6 9.4 0.0 3.3 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 EKX72449.1 - 0.00073 19.3 0.1 2 8.1 0.0 3.0 3 0 0 3 3 3 2 AAA domain TsaE PF02367.17 EKX72449.1 - 0.0012 18.8 0.0 2 8.5 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EKX72449.1 - 0.0012 19.3 0.5 0.23 11.9 0.0 3.5 3 1 0 3 3 3 1 ABC transporter NACHT PF05729.12 EKX72449.1 - 0.0013 18.7 0.0 0.69 9.8 0.0 2.7 3 0 0 3 3 2 1 NACHT domain betaPIX_CC PF16523.5 EKX72449.1 - 0.005 16.6 1.8 0.018 14.8 1.8 2.0 1 0 0 1 1 1 1 betaPIX coiled coil AAA_19 PF13245.6 EKX72449.1 - 0.0052 17.1 0.0 1.4 9.2 0.0 3.3 3 1 0 3 3 3 1 AAA domain ResIII PF04851.15 EKX72449.1 - 0.0053 16.8 0.0 0.56 10.2 0.0 3.1 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit NTPase_1 PF03266.15 EKX72449.1 - 0.0059 16.5 2.4 5.2 6.9 0.0 4.0 4 0 0 4 4 4 0 NTPase Bac_DnaA PF00308.18 EKX72449.1 - 0.006 16.4 0.0 5.4 6.8 0.0 3.3 4 0 0 4 4 3 0 Bacterial dnaA protein Zeta_toxin PF06414.12 EKX72449.1 - 0.0066 15.8 0.1 0.92 8.7 0.0 3.1 3 0 0 3 3 2 1 Zeta toxin AAA_3 PF07726.11 EKX72449.1 - 0.011 15.5 0.0 3.1 7.7 0.0 3.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 EKX72449.1 - 0.03 13.9 0.0 0.25 10.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 EKX72449.1 - 0.051 13.3 0.0 0.31 10.8 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.6 EKX72449.1 - 0.073 12.8 0.1 16 5.1 0.0 3.3 2 1 0 3 3 3 0 AAA domain AAA_33 PF13671.6 EKX72449.1 - 0.078 13.1 0.0 17 5.6 0.0 3.2 2 1 0 2 2 2 0 AAA domain Cyclin_N PF00134.23 EKX72449.1 - 0.089 12.5 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 Cyclin, N-terminal domain AAA_28 PF13521.6 EKX72449.1 - 0.12 12.6 0.0 14 5.9 0.0 3.0 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 EKX72449.1 - 0.14 11.8 0.5 3 7.4 0.0 2.7 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain DUF87 PF01935.17 EKX72449.1 - 0.18 11.9 6.5 0.85 9.7 0.0 4.1 4 1 1 5 5 4 0 Helicase HerA, central domain DUF1664 PF07889.12 EKX72449.1 - 0.24 11.4 1.5 0.87 9.6 0.3 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) KELK PF15796.5 EKX72449.1 - 6.1 7.4 9.9 19 5.8 1.8 4.3 5 0 0 5 5 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase FAINT PF04385.15 EKX72451.1 - 9.1e-15 54.5 0.5 4e-07 30.0 0.0 2.7 2 0 0 2 2 2 2 Domain of unknown function, DUF529 MAM PF00629.23 EKX72451.1 - 0.074 13.0 0.7 0.21 11.5 0.1 2.0 2 0 0 2 2 2 0 MAM domain, meprin/A5/mu HTH_Tnp_Tc3_1 PF11427.8 EKX72452.1 - 0.13 12.1 0.0 0.56 10.1 0.0 2.0 2 0 0 2 2 2 0 Tc3 transposase SpoIISA_toxin PF14171.6 EKX72452.1 - 0.2 11.3 0.0 0.33 10.6 0.0 1.4 1 1 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system AdoHcyase PF05221.17 EKX72454.1 - 5.7e-84 281.8 0.0 6.8e-84 281.5 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 EKX72454.1 - 9.4e-57 191.6 2.8 1.3e-56 191.1 2.8 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EKX72454.1 - 7.6e-08 31.9 0.4 1.7e-07 30.8 0.4 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EKX72454.1 - 0.00079 19.0 0.4 0.0013 18.3 0.4 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_7 PF13241.6 EKX72454.1 - 0.0091 16.4 0.3 0.02 15.3 0.3 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding THF_DHG_CYH_C PF02882.19 EKX72454.1 - 0.029 13.7 1.7 0.21 10.9 1.7 2.0 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain XdhC_C PF13478.6 EKX72454.1 - 0.045 14.2 0.1 0.53 10.8 0.1 2.1 2 0 0 2 2 2 0 XdhC Rossmann domain Shikimate_DH PF01488.20 EKX72454.1 - 0.06 13.4 0.1 0.14 12.2 0.1 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 EKX72454.1 - 0.29 11.4 1.2 1.3 9.3 1.2 2.1 1 1 0 1 1 1 0 TrkA-N domain AlaDh_PNT_C PF01262.21 EKX72454.1 - 0.9 8.8 8.1 1.3 8.3 5.8 2.3 2 1 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain VSP PF03302.13 EKX72455.1 - 0.13 11.1 0.2 0.17 10.7 0.2 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein DUF2507 PF10702.9 EKX72456.1 - 0.15 12.0 0.0 0.48 10.4 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2507) Prominin PF05478.11 EKX72458.1 - 0.056 11.4 0.0 0.081 10.9 0.0 1.1 1 0 0 1 1 1 0 Prominin F-box PF00646.33 EKX72459.1 - 8.2e-05 22.4 1.4 0.00021 21.1 0.5 2.3 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EKX72459.1 - 0.0064 16.4 0.7 0.019 14.8 0.7 1.8 1 0 0 1 1 1 1 F-box-like Endonuc-MspI PF09208.10 EKX72459.1 - 0.092 12.1 0.2 0.21 10.9 0.1 1.6 2 0 0 2 2 2 0 Restriction endonuclease MspI Trypan_PARP PF05887.11 EKX72464.1 - 1.8 8.5 14.0 4.1 7.4 14.0 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Fib_alpha PF08702.10 EKX72464.1 - 2.8 8.1 5.3 6.2 7.0 3.5 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family TFIIA PF03153.13 EKX72464.1 - 3 7.8 12.8 4.8 7.1 12.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAINT PF04385.15 EKX72465.1 - 3e-21 75.3 13.5 7e-07 29.2 0.5 4.4 5 0 0 5 5 5 3 Domain of unknown function, DUF529 TetR_C_19 PF17924.1 EKX72467.1 - 0.0041 17.7 0.1 0.0054 17.3 0.1 1.2 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain Gal4_dimer PF03902.13 EKX72467.1 - 0.062 13.5 0.3 0.38 10.9 0.3 2.1 2 0 0 2 2 2 0 Gal4-like dimerisation domain FAINT PF04385.15 EKX72468.1 - 1.4e-16 60.3 0.2 6.2e-07 29.4 0.3 2.6 2 1 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72469.1 - 3.4e-95 312.2 83.6 5.1e-07 29.7 0.1 18.6 18 0 0 18 18 18 18 Domain of unknown function, DUF529 DUF4028 PF13220.6 EKX72469.1 - 0.005 16.6 7.2 4 7.3 0.1 5.2 5 0 0 5 5 5 2 Protein of unknown function (DUF4028) Y_Y_Y PF07495.13 EKX72469.1 - 0.13 12.2 9.5 0.99 9.4 0.0 5.8 6 0 0 6 6 6 0 Y_Y_Y domain C1_2 PF03107.16 EKX72470.1 - 0.14 12.5 8.0 2.6 8.4 0.2 3.0 3 0 0 3 3 3 0 C1 domain Elf1 PF05129.13 EKX72470.1 - 1.6 8.8 7.9 2.4 8.3 1.6 2.5 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like DUF2482 PF10655.9 EKX72472.1 - 0.12 12.9 2.0 3.7 8.1 0.1 2.7 2 0 0 2 2 2 0 Hypothetical protein of unknown function (DUF2482) DUF4871 PF16167.5 EKX72473.1 - 0.027 14.5 0.0 0.072 13.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4871) HhH-GPD PF00730.25 EKX72474.1 - 2.1e-22 79.6 0.0 3.5e-22 78.9 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EKX72474.1 - 1.8e-09 37.0 0.8 1.4e-08 34.2 0.0 2.6 3 0 0 3 3 3 1 Helix-hairpin-helix motif HHH_5 PF14520.6 EKX72474.1 - 0.056 14.1 0.2 2 9.1 0.0 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix domain Ribosomal_L19e PF01280.20 EKX72475.1 - 9e-59 197.7 3.5 9e-59 197.7 3.5 1.5 1 1 1 2 2 2 1 Ribosomal protein L19e HMw1_D2 PF18254.1 EKX72475.1 - 0.024 15.0 0.4 0.046 14.1 0.4 1.5 1 0 0 1 1 1 0 HMW1 domain 2 CSN8_PSD8_EIF3K PF10075.9 EKX72476.1 - 2.3e-16 60.1 0.2 2.5e-14 53.5 0.0 2.2 2 0 0 2 2 2 2 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 EKX72476.1 - 8.4e-05 22.1 0.4 0.00014 21.4 0.4 1.2 1 0 0 1 1 1 1 SAC3/GANP family Fe_hyd_lg_C PF02906.14 EKX72477.1 - 3.3e-38 131.7 0.0 4.2e-37 128.1 0.0 2.4 1 1 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain ABC_tran PF00005.27 EKX72478.1 - 8.3e-29 100.9 0.0 5.6e-13 49.6 0.0 3.2 2 1 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EKX72478.1 - 1.8e-13 50.8 7.6 1.8e-13 50.8 7.6 3.2 2 1 0 2 2 1 1 ABC transporter transmembrane region AAA_23 PF13476.6 EKX72478.1 - 2e-07 31.7 0.1 0.022 15.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EKX72478.1 - 2.6e-07 30.7 0.1 0.021 14.7 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 EKX72478.1 - 9.8e-07 28.9 0.9 0.064 13.1 0.0 3.6 5 0 0 5 5 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EKX72478.1 - 1.2e-06 28.2 1.1 0.01 15.6 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EKX72478.1 - 3.4e-06 27.1 0.1 0.019 15.0 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase SMC_N PF02463.19 EKX72478.1 - 0.00069 19.1 3.7 0.038 13.4 0.1 4.0 5 0 0 5 5 5 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EKX72478.1 - 0.00084 19.6 3.7 2.8 8.2 0.1 3.5 3 0 0 3 3 3 1 AAA domain Dynamin_N PF00350.23 EKX72478.1 - 0.00089 19.4 2.7 0.53 10.3 0.0 3.3 3 0 0 3 3 3 2 Dynamin family Adeno_IVa2 PF02456.15 EKX72478.1 - 0.0028 16.5 0.1 0.52 9.0 0.1 2.5 2 0 0 2 2 2 1 Adenovirus IVa2 protein AAA_18 PF13238.6 EKX72478.1 - 0.0039 17.7 1.5 5.1 7.6 0.0 3.6 4 0 0 4 4 4 1 AAA domain AAA_15 PF13175.6 EKX72478.1 - 0.014 15.1 0.3 0.46 10.1 0.0 2.7 3 0 0 3 3 2 0 AAA ATPase domain IstB_IS21 PF01695.17 EKX72478.1 - 0.014 15.1 3.6 0.31 10.8 0.0 3.4 4 0 0 4 4 4 0 IstB-like ATP binding protein T2SSE PF00437.20 EKX72478.1 - 0.016 14.3 0.0 0.51 9.3 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_16 PF13191.6 EKX72478.1 - 0.03 14.7 0.2 3.6 7.9 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_30 PF13604.6 EKX72478.1 - 0.03 14.0 0.6 13 5.5 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_27 PF13514.6 EKX72478.1 - 0.068 12.7 0.0 9.2 5.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain Helicase_RecD PF05127.14 EKX72478.1 - 0.076 12.9 0.0 0.26 11.1 0.0 1.9 1 0 0 1 1 1 0 Helicase AAA_33 PF13671.6 EKX72478.1 - 0.092 12.9 0.0 23 5.1 0.1 2.8 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EKX72478.1 - 0.1 12.1 0.1 2.3 7.7 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region MeaB PF03308.16 EKX72478.1 - 0.11 11.5 0.5 0.23 10.4 0.1 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB FtsK_SpoIIIE PF01580.18 EKX72478.1 - 0.12 11.7 1.9 11 5.3 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family ATP_bind_1 PF03029.17 EKX72478.1 - 0.14 11.9 1.0 5.3 6.8 0.2 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 EKX72478.1 - 0.18 11.6 2.1 3.4 7.4 0.1 2.9 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 EKX72478.1 - 0.21 11.1 1.5 15 5.2 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.17 EKX72478.1 - 7.1 6.6 6.8 2.5 8.1 0.1 3.2 4 0 0 4 4 3 0 Helicase HerA, central domain Hydrolase_3 PF08282.12 EKX72479.1 - 2.5e-26 92.9 0.0 4.4e-26 92.1 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EKX72479.1 - 6.3e-05 22.6 0.0 0.11 12.0 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase FAINT PF04385.15 EKX72481.1 - 2e-18 66.2 0.0 3.1e-05 24.0 0.4 3.4 3 0 0 3 3 3 3 Domain of unknown function, DUF529 DUF883 PF05957.13 EKX72481.1 - 0.28 11.8 1.3 40 4.9 0.3 2.8 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF1281 PF06924.11 EKX72483.1 - 0.076 12.6 0.0 0.85 9.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1281) PP2 PF14299.6 EKX72485.1 - 0.024 14.7 0.0 0.029 14.4 0.0 1.2 1 0 0 1 1 1 0 Phloem protein 2 Piezo_RRas_bdg PF12166.8 EKX72487.1 - 0.026 13.8 0.1 0.032 13.5 0.1 1.1 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain Sugar_tr PF00083.24 EKX72493.1 - 6.9e-62 209.8 32.3 8.5e-62 209.5 32.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EKX72493.1 - 1.7e-12 47.0 34.2 3e-12 46.2 27.8 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EKX72493.1 - 4.9e-05 21.9 2.9 4.9e-05 21.9 2.9 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) CYYR1 PF10873.8 EKX72493.1 - 1 9.8 8.0 0.11 13.0 1.8 2.5 2 1 0 2 2 2 0 Cysteine and tyrosine-rich protein 1 BORCS7 PF16088.5 EKX72494.1 - 0.024 14.9 0.2 0.068 13.4 0.2 1.8 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 7 Pigment_DH PF06324.11 EKX72495.1 - 0.037 14.1 0.3 0.2 11.8 0.3 2.4 1 0 0 1 1 1 0 Pigment-dispersing hormone (PDH) FAINT PF04385.15 EKX72496.1 - 8.6e-05 22.5 0.3 0.061 13.4 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function, DUF529 PPR_3 PF13812.6 EKX72496.1 - 0.037 14.1 0.5 5.7 7.1 0.0 2.4 1 1 1 2 2 2 0 Pentatricopeptide repeat domain FAINT PF04385.15 EKX72497.1 - 2.3e-10 40.4 0.3 0.00068 19.6 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function, DUF529 HobA PF12163.8 EKX72497.1 - 0.049 13.2 0.3 0.42 10.2 0.1 2.1 2 1 0 2 2 2 0 DNA replication regulator Beta-Casp PF10996.8 EKX72498.1 - 5.4e-23 81.4 0.0 1.1e-22 80.4 0.0 1.5 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 EKX72498.1 - 6e-17 61.3 0.1 1e-16 60.6 0.1 1.4 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_6 PF16661.5 EKX72498.1 - 1.1e-14 54.3 0.0 3.8e-14 52.6 0.0 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 EKX72498.1 - 3.3e-09 37.1 0.2 7.2e-08 32.7 0.2 2.4 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EKX72498.1 - 2.6e-05 23.8 0.4 0.0021 17.6 0.1 2.9 2 1 0 2 2 2 1 Beta-lactamase superfamily domain FtsJ PF01728.19 EKX72499.1 - 1.3e-33 116.6 0.0 1.8e-25 90.0 0.0 2.4 2 0 0 2 2 2 2 FtsJ-like methyltransferase Methyltrans_Mon PF14314.6 EKX72499.1 - 3e-06 25.6 1.4 0.024 12.7 0.3 2.3 2 0 0 2 2 2 2 Virus-capping methyltransferase Pox_mRNA-cap PF03341.13 EKX72499.1 - 0.16 11.2 4.1 0.16 11.3 0.2 2.4 2 0 0 2 2 2 0 Poxvirus mRNA capping enzyme, small subunit DUF2682 PF10909.8 EKX72502.1 - 0.13 12.8 0.1 0.3 11.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2682) FAINT PF04385.15 EKX72505.1 - 4.2e-10 39.5 0.2 6.2e-10 39.0 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72506.1 - 1.9e-06 27.8 5.8 0.00043 20.3 0.2 3.1 3 1 1 4 4 4 2 Domain of unknown function, DUF529 Kinesin_assoc PF16183.5 EKX72506.1 - 0.0072 16.5 0.2 0.016 15.3 0.0 1.6 2 0 0 2 2 2 1 Kinesin-associated Baculo_IE-1 PF05290.11 EKX72506.1 - 0.048 13.6 0.1 0.085 12.8 0.1 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) MarR_2 PF12802.7 EKX72508.1 - 0.012 15.5 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 MarR family CAP_C PF08603.11 EKX72511.1 - 8.9e-34 116.4 2.5 1.7e-33 115.4 2.5 1.4 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal Imm6 PF14434.6 EKX72511.1 - 0.0049 16.8 0.1 0.021 14.8 0.1 2.0 1 1 1 2 2 2 1 Immunity protein Imm6 TBCC PF07986.12 EKX72511.1 - 0.14 11.9 3.2 0.37 10.5 3.2 1.7 1 0 0 1 1 1 0 Tubulin binding cofactor C Hydrolase_4 PF12146.8 EKX72512.1 - 1e-22 80.6 0.0 1.8e-21 76.5 0.0 2.6 2 1 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX72512.1 - 3.4e-10 39.9 3.1 3e-06 27.2 0.0 4.6 4 1 1 5 5 5 2 Domain of unknown function, DUF529 Abhydrolase_1 PF00561.20 EKX72512.1 - 1e-05 25.3 0.0 0.00052 19.7 0.0 2.9 3 0 0 3 3 3 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EKX72512.1 - 0.0003 20.3 0.0 0.0016 17.9 0.0 2.1 3 0 0 3 3 3 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 EKX72512.1 - 0.081 12.8 0.0 0.31 10.9 0.0 1.9 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EKX72512.1 - 0.15 11.8 0.3 1.2 8.9 0.1 2.4 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase FAINT PF04385.15 EKX72515.1 - 6.5e-14 51.8 7.0 2.2e-05 24.4 0.1 3.7 3 1 0 3 3 3 3 Domain of unknown function, DUF529 DUF4362 PF14275.6 EKX72515.1 - 0.0029 17.8 0.0 0.0076 16.5 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4362) EMA PF02488.15 EKX72515.1 - 0.0049 16.6 0.4 0.84 9.3 0.0 2.3 2 0 0 2 2 2 2 Merozoite Antigen FAINT PF04385.15 EKX72516.1 - 3.6e-06 26.9 4.9 0.085 12.9 1.6 3.8 4 0 0 4 4 4 2 Domain of unknown function, DUF529 PepSY PF03413.19 EKX72516.1 - 0.054 14.1 1.6 1.2 9.8 0.1 2.9 3 0 0 3 3 3 0 Peptidase propeptide and YPEB domain SAP PF02037.27 EKX72517.1 - 1.5e-11 43.8 0.2 4.5e-11 42.2 0.2 1.9 1 0 0 1 1 1 1 SAP domain Peptidase_C37 PF05416.12 EKX72517.1 - 0.01 14.4 1.6 0.011 14.3 1.6 1.1 1 0 0 1 1 1 0 Southampton virus-type processing peptidase Tho1_MOS11_C PF18592.1 EKX72517.1 - 1.6 8.6 11.8 7.3 6.5 4.6 2.7 1 1 1 2 2 2 0 Tho1/MOS11 C-terminal domain PhoD PF09423.10 EKX72518.1 - 2.4e-07 30.1 0.0 3.6e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 PhoD-like phosphatase PhoD PF09423.10 EKX72519.1 - 0.0075 15.3 0.2 0.0092 15.0 0.2 1.2 1 0 0 1 1 1 1 PhoD-like phosphatase Acetyltransf_9 PF13527.7 EKX72520.1 - 0.042 13.9 0.0 0.72 9.9 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Methyltransf_16 PF10294.9 EKX72523.1 - 0.022 14.5 0.0 0.043 13.5 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase DUF3278 PF11683.8 EKX72527.1 - 2.2 8.4 9.6 21 5.2 0.0 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3278) FAINT PF04385.15 EKX72528.1 - 7.9e-23 80.3 8.1 4.7e-05 23.4 0.0 6.3 6 1 0 6 6 6 5 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72529.1 - 0.00036 20.5 0.1 0.00083 19.4 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function, DUF529 Frtz PF11768.8 EKX72532.1 - 0.029 12.7 0.6 0.035 12.4 0.6 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Cytochrom_B561 PF03188.16 EKX72532.1 - 0.11 12.7 0.1 0.11 12.7 0.1 1.8 2 0 0 2 2 2 0 Eukaryotic cytochrome b561 SPC25 PF06703.11 EKX72534.1 - 0.014 15.2 0.7 2.1 8.1 0.0 2.3 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Cpn60_TCP1 PF00118.24 EKX72535.1 - 4.3e-154 513.8 8.7 4.9e-154 513.6 8.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF3797 PF12677.7 EKX72536.1 - 0.029 14.2 2.5 0.42 10.5 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) Ribosomal_L37ae PF01780.19 EKX72536.1 - 0.038 14.1 0.5 1.7 8.8 0.1 2.3 2 0 0 2 2 2 0 Ribosomal L37ae protein family zf-HIT PF04438.16 EKX72536.1 - 0.057 13.3 3.1 3.8 7.5 0.3 2.6 2 0 0 2 2 2 0 HIT zinc finger zf-ribbon_3 PF13248.6 EKX72536.1 - 0.18 11.3 5.1 0.67 9.5 0.3 2.7 2 0 0 2 2 2 0 zinc-ribbon domain zf-C2HC5 PF06221.13 EKX72536.1 - 0.36 10.9 2.5 2.5 8.2 0.3 2.3 2 0 0 2 2 2 0 Putative zinc finger motif, C2HC5-type zinc_ribbon_10 PF10058.9 EKX72536.1 - 0.38 10.5 5.7 0.34 10.7 0.4 2.4 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Zn-ribbon_8 PF09723.10 EKX72536.1 - 0.39 10.9 3.5 2.3 8.4 0.1 2.4 2 0 0 2 2 2 0 Zinc ribbon domain DUF2752 PF10825.8 EKX72536.1 - 0.45 10.6 1.2 2.4 8.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2752) CDC50 PF03381.15 EKX72537.1 - 1.7e-23 83.5 0.1 2.7e-23 82.9 0.1 1.3 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family RNA_pol_Rpb1_5 PF04998.17 EKX72538.1 - 5.3e-101 337.5 0.1 1.6e-100 335.9 0.1 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 EKX72538.1 - 5.2e-100 334.8 0.1 1.1e-99 333.7 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 EKX72538.1 - 5.7e-73 244.6 0.0 1e-72 243.7 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 EKX72538.1 - 1.9e-47 161.6 0.1 3.7e-47 160.6 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_7 PF04990.12 EKX72538.1 - 6.1e-46 155.8 2.7 1.2e-45 154.8 2.7 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_3 PF04983.18 EKX72538.1 - 3.4e-45 153.8 0.0 7.1e-45 152.8 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EKX72538.1 - 2.6e-37 127.1 0.6 6.4e-37 125.8 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 EKX72538.1 - 8.5e-21 73.2 239.5 0.0051 17.1 12.2 14.0 9 3 2 14 14 14 11 RNA polymerase Rpb1 C-terminal repeat Band_7 PF01145.25 EKX72539.1 - 9.2e-27 94.2 0.0 9.2e-27 94.2 0.0 1.8 2 0 0 2 2 2 1 SPFH domain / Band 7 family Band_7_C PF16200.5 EKX72539.1 - 3.4e-21 75.1 0.7 1.5e-20 73.0 0.1 2.2 2 0 0 2 2 2 1 C-terminal region of band_7 Band_7_1 PF13421.6 EKX72539.1 - 0.0033 17.2 0.0 0.0068 16.1 0.0 1.5 1 0 0 1 1 1 1 SPFH domain-Band 7 family MHCassoc_trimer PF08831.10 EKX72541.1 - 0.039 14.0 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 Class II MHC-associated invariant chain trimerisation domain Flavi_NS4A PF01350.17 EKX72541.1 - 1 9.3 4.0 2.2 8.2 0.4 2.9 3 0 0 3 3 3 0 Flavivirus non-structural protein NS4A FAINT PF04385.15 EKX72542.1 - 6e-05 23.0 0.0 0.0021 18.1 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Caldesmon PF02029.15 EKX72543.1 - 0.47 9.1 43.4 0.62 8.8 43.4 1.1 1 0 0 1 1 1 0 Caldesmon ADK_lid PF05191.14 EKX72544.1 - 0.17 11.9 0.1 0.36 10.8 0.1 1.6 1 0 0 1 1 1 0 Adenylate kinase, active site lid Ribosomal_L21p PF00829.21 EKX72546.1 - 1.8e-21 76.3 0.0 2.9e-21 75.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein ProRS-C_2 PF09181.10 EKX72547.1 - 0.0054 16.8 0.2 0.065 13.4 0.0 2.4 2 0 0 2 2 2 1 Prolyl-tRNA synthetase, C-terminal GTP_EFTU PF00009.27 EKX72548.1 - 2.6e-32 112.0 4.0 8.9e-31 106.9 4.0 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKX72548.1 - 9.8e-11 41.7 4.4 7.6e-10 38.9 0.2 3.4 3 1 0 3 3 3 1 50S ribosome-binding GTPase Ras PF00071.22 EKX72548.1 - 9.1e-10 38.4 2.4 3.7e-07 29.9 0.1 2.8 2 0 0 2 2 2 2 Ras family IF-2 PF11987.8 EKX72548.1 - 2.7e-07 30.7 0.2 0.00053 20.1 0.0 3.6 3 1 0 3 3 3 2 Translation-initiation factor 2 MMR_HSR1_Xtn PF16897.5 EKX72548.1 - 7.1e-06 26.0 0.5 3.4e-05 23.8 0.1 2.4 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain Arf PF00025.21 EKX72548.1 - 2.2e-05 24.0 0.1 5.1e-05 22.8 0.1 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family FeoB_N PF02421.18 EKX72548.1 - 3.4e-05 23.4 1.0 0.00022 20.8 1.0 2.3 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EKX72548.1 - 3.8e-05 23.7 1.5 0.096 12.6 0.2 2.7 1 1 1 2 2 2 2 RsgA GTPase SRPRB PF09439.10 EKX72548.1 - 5e-05 22.8 1.2 0.00026 20.5 1.2 2.1 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EKX72548.1 - 0.00019 21.7 0.6 0.00074 19.7 0.0 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 EKX72548.1 - 0.013 15.3 0.6 0.054 13.2 0.6 2.1 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 EKX72548.1 - 0.015 15.3 0.0 3.2 7.8 0.0 2.6 1 1 1 2 2 2 0 Dynamin family eIF2_C PF09173.11 EKX72548.1 - 0.079 13.2 0.1 0.34 11.2 0.1 2.1 1 0 0 1 1 1 0 Initiation factor eIF2 gamma, C terminal Cullin_Nedd8 PF10557.9 EKX72548.1 - 0.63 10.1 3.1 8.8 6.5 0.0 3.9 4 0 0 4 4 4 0 Cullin protein neddylation domain DEAD PF00270.29 EKX72549.1 - 4.5e-43 147.0 0.0 1.1e-42 145.8 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKX72549.1 - 1.6e-23 83.2 2.7 1.5e-22 80.0 0.1 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 EKX72549.1 - 4.6e-08 33.2 4.1 4.6e-08 33.2 4.1 2.6 2 0 0 2 2 2 1 DBP10CT (NUC160) domain AAA_22 PF13401.6 EKX72549.1 - 0.56 10.5 2.1 1.2 9.4 0.2 2.5 2 1 0 2 2 2 0 AAA domain DUF2135 PF09906.9 EKX72551.1 - 0.014 15.7 2.4 3.7 7.9 0.3 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2135) Hydrolase_3 PF08282.12 EKX72552.1 - 3.2e-35 122.1 0.0 8.1e-35 120.8 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EKX72552.1 - 0.00087 19.6 0.0 0.0072 16.6 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EKX72552.1 - 0.0066 16.0 0.0 0.04 13.4 0.0 2.0 3 0 0 3 3 3 1 Sucrose-6F-phosphate phosphohydrolase Mitofilin PF09731.9 EKX72553.1 - 0.031 13.1 30.1 0.036 12.9 30.1 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Salp15 PF12115.8 EKX72553.1 - 0.082 13.3 0.0 1.2 9.6 0.0 2.7 1 1 0 1 1 1 0 Salivary protein of 15kDa inhibits CD4+ T cell activation Erythro-docking PF09277.11 EKX72553.1 - 0.12 12.3 0.0 0.56 10.2 0.0 2.2 2 0 0 2 2 2 0 Erythronolide synthase, docking GP41 PF00517.17 EKX72553.1 - 1.2 9.1 5.8 1.6 8.6 0.2 2.6 2 1 1 3 3 3 0 Retroviral envelope protein Aldedh PF00171.22 EKX72553.1 - 1.7 7.1 5.8 0.52 8.8 3.1 1.5 1 1 0 1 1 1 0 Aldehyde dehydrogenase family Hid1 PF12722.7 EKX72553.1 - 3 5.8 16.1 3.6 5.6 16.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FAINT PF04385.15 EKX72554.1 - 4.9e-35 119.4 14.6 0.00016 21.7 0.0 7.7 7 0 0 7 7 7 7 Domain of unknown function, DUF529 EMA PF02488.15 EKX72554.1 - 0.00065 19.4 21.1 0.0026 17.5 1.0 4.6 4 1 1 5 5 5 2 Merozoite Antigen RNA_pol_A_bac PF01000.26 EKX72555.1 - 2.3e-08 34.4 0.0 5.6e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain FAINT PF04385.15 EKX72556.1 - 0.00029 20.8 0.0 0.00057 19.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function, DUF529 AAA_lid_11 PF18198.1 EKX72557.1 - 0.091 12.6 0.1 0.16 11.8 0.1 1.4 1 0 0 1 1 1 0 Dynein heavy chain AAA lid domain YolD PF08863.10 EKX72558.1 - 0.1 12.7 1.5 0.4 10.8 0.1 2.5 3 0 0 3 3 3 0 YolD-like protein FAINT PF04385.15 EKX72561.1 - 3.8e-14 52.5 1.0 4e-07 30.0 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 IgGFc_binding PF17517.2 EKX72561.1 - 0.055 12.7 0.0 0.34 10.1 0.0 1.9 2 0 0 2 2 2 0 IgGFc binding protein FAINT PF04385.15 EKX72562.1 - 0.014 15.5 0.0 3.8 7.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function, DUF529 RRM_1 PF00076.22 EKX72563.1 - 2.2e-13 49.8 0.0 5.4e-05 22.9 0.0 5.0 3 2 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EKX72563.1 - 0.038 14.0 0.0 0.074 13.1 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif DNA_topoisoIV PF00521.20 EKX72563.1 - 0.11 11.4 0.1 0.15 10.9 0.1 1.2 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A PglD_N PF17836.1 EKX72563.1 - 0.2 12.3 0.1 0.47 11.1 0.1 1.6 1 0 0 1 1 1 0 PglD N-terminal domain IL2 PF00715.17 EKX72565.1 - 0.095 12.6 0.6 0.4 10.6 0.1 2.3 2 0 0 2 2 2 0 Interleukin 2 Hydrolase_4 PF12146.8 EKX72569.1 - 3.2e-24 85.5 0.0 1.5e-23 83.3 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX72569.1 - 1.4e-15 57.1 4.3 6.7e-05 22.9 0.0 3.9 3 0 0 3 3 3 3 Domain of unknown function, DUF529 Abhydrolase_6 PF12697.7 EKX72569.1 - 0.00021 22.0 0.0 0.00074 20.2 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EKX72569.1 - 0.00029 20.6 0.0 0.0012 18.5 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EKX72569.1 - 0.12 11.8 0.1 2.6 7.4 0.0 2.8 3 0 0 3 3 3 0 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 EKX72569.1 - 0.12 12.1 0.1 7.6 6.3 0.0 2.4 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase FAINT PF04385.15 EKX72570.1 - 3.4e-12 46.2 4.6 1e-05 25.5 2.2 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 zf-NPL4 PF05020.15 EKX72571.1 - 0.0054 16.9 0.4 0.01 16.0 0.4 1.4 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region PTP_tm PF18861.1 EKX72571.1 - 0.05 13.6 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J DNA_pol_B PF00136.21 EKX72572.1 - 4.9e-96 322.2 0.2 1.2e-95 321.0 0.2 1.5 1 1 0 1 1 1 1 DNA polymerase family B FAINT PF04385.15 EKX72572.1 - 9e-17 60.9 10.5 2.1e-05 24.5 0.3 4.8 5 0 0 5 5 5 3 Domain of unknown function, DUF529 DNA_pol_B_2 PF03175.13 EKX72572.1 - 0.0063 15.4 0.0 0.046 12.6 0.0 2.1 2 0 0 2 2 2 1 DNA polymerase type B, organellar and viral DNA_pol_B_exo1 PF03104.19 EKX72573.1 - 1.1e-23 83.9 0.8 2e-23 83.1 0.8 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 EKX72573.1 - 5.7e-12 45.5 7.5 1.2e-11 44.4 7.5 1.6 1 0 0 1 1 1 1 DNA polymerase alpha subunit p180 N terminal WD40 PF00400.32 EKX72574.1 - 4.1e-13 49.6 1.3 0.025 15.4 0.0 6.0 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKX72574.1 - 1.5e-08 34.8 0.0 0.018 15.4 0.0 4.8 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain TFIIIC_delta PF12657.7 EKX72574.1 - 0.002 18.1 1.5 5 7.0 0.0 3.9 3 2 1 4 4 4 2 Transcription factor IIIC subunit delta N-term Ge1_WD40 PF16529.5 EKX72574.1 - 0.069 12.1 0.3 1.3 7.9 0.0 2.8 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 EKX72574.1 - 0.15 12.0 1.2 17 5.5 0.1 3.1 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 EKX72575.1 - 1.1e-10 41.9 1.1 9.2e-07 29.5 0.1 2.8 2 1 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKX72575.1 - 0.036 14.3 0.1 0.11 12.8 0.0 1.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain OTOS PF15182.6 EKX72576.1 - 0.011 15.6 0.0 0.025 14.5 0.0 1.6 1 0 0 1 1 1 0 Otospiralin AKAP2_C PF15304.6 EKX72577.1 - 1.7 7.9 7.4 0.8 8.9 1.5 2.1 2 0 0 2 2 2 0 A-kinase anchor protein 2 C-terminus Thioredoxin PF00085.20 EKX72579.1 - 2.4e-06 27.5 0.0 8.7e-06 25.7 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_7 PF13899.6 EKX72579.1 - 0.1 12.8 0.0 7.1 6.9 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin-like NTP_transf_2 PF01909.23 EKX72580.1 - 1.1e-05 25.6 0.0 3.3e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 EKX72580.1 - 0.0019 18.4 0.5 0.012 15.8 0.0 2.4 2 0 0 2 2 2 1 Cid1 family poly A polymerase Polbeta PF18765.1 EKX72580.1 - 0.059 13.5 0.2 0.41 10.7 0.0 2.5 3 0 0 3 3 3 0 Polymerase beta, Nucleotidyltransferase DUF5577 PF17740.1 EKX72580.1 - 0.12 12.0 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5577) Cpn60_TCP1 PF00118.24 EKX72581.1 - 6.2e-77 259.3 5.2 9.3e-77 258.7 5.2 1.3 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family ANAPC4_WD40 PF12894.7 EKX72582.1 - 0.0028 17.9 1.1 4.6 7.6 0.0 4.1 5 0 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain DUF572 PF04502.13 EKX72583.1 - 1.6e-49 169.4 3.9 2.1e-49 168.9 3.9 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF572) Hydrolase_4 PF12146.8 EKX72586.1 - 1e-17 64.2 0.0 7e-17 61.5 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX72586.1 - 4.2e-15 55.6 18.3 5.5e-06 26.4 0.3 5.4 5 0 0 5 5 5 3 Domain of unknown function, DUF529 Abhydrolase_3 PF07859.13 EKX72586.1 - 0.18 11.6 0.0 0.32 10.8 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold FAINT PF04385.15 EKX72588.1 - 1.9e-40 136.8 7.0 2.5e-10 40.2 0.1 5.5 5 0 0 5 5 5 5 Domain of unknown function, DUF529 DUF4251 PF14059.6 EKX72588.1 - 0.05 13.6 0.3 0.1 12.6 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4251) FAINT PF04385.15 EKX72589.1 - 1.8e-43 146.5 11.1 8.5e-08 32.2 0.0 7.8 7 0 0 7 7 7 7 Domain of unknown function, DUF529 Claudin_2 PF13903.6 EKX72591.1 - 0.0058 16.4 0.0 0.0058 16.4 0.0 2.9 2 2 1 4 4 4 1 PMP-22/EMP/MP20/Claudin tight junction SabA_adhesion PF18304.1 EKX72592.1 - 0.0094 15.2 0.2 0.013 14.7 0.2 1.3 1 1 0 1 1 1 1 SabA N-terminal extracellular adhesion domain FAINT PF04385.15 EKX72593.1 - 3.6e-06 26.9 0.1 6e-06 26.2 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 Beta_helix_2 PF18835.1 EKX72593.1 - 0.13 12.0 0.2 0.23 11.3 0.2 1.4 1 0 0 1 1 1 0 Beta helix repeat of Inulin fructotransferase FAINT PF04385.15 EKX72594.1 - 6.6e-07 29.3 0.1 1.2e-06 28.4 0.1 1.5 1 1 0 1 1 1 1 Domain of unknown function, DUF529 Cpn60_TCP1 PF00118.24 EKX72595.1 - 2.6e-152 507.9 6.5 3e-152 507.7 6.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Adeno_52K PF03052.15 EKX72596.1 - 0.034 13.6 0.0 0.05 13.1 0.0 1.2 1 0 0 1 1 1 0 Adenoviral protein L1 52/55-kDa SF3b1 PF08920.10 EKX72597.1 - 1.8e-21 76.8 8.2 5.2e-18 65.7 0.2 3.0 2 1 1 3 3 3 2 Splicing factor 3B subunit 1 HEAT_2 PF13646.6 EKX72597.1 - 9.6e-12 45.1 7.5 0.079 13.4 0.0 7.9 5 2 3 8 8 8 3 HEAT repeats HEAT_EZ PF13513.6 EKX72597.1 - 8.9e-08 32.5 8.8 0.026 15.1 0.0 7.0 8 1 1 9 9 8 3 HEAT-like repeat HEAT PF02985.22 EKX72597.1 - 8.8e-07 28.7 9.5 0.066 13.5 0.1 7.9 9 0 0 9 9 9 1 HEAT repeat Adaptin_N PF01602.20 EKX72597.1 - 9.4e-06 24.5 2.0 0.43 9.1 0.0 4.1 3 1 0 4 4 4 2 Adaptin N terminal region CLASP_N PF12348.8 EKX72597.1 - 0.00054 19.6 0.3 1.5 8.4 0.0 3.1 3 1 0 3 3 3 2 CLASP N terminal Cnd1 PF12717.7 EKX72597.1 - 0.0031 17.6 0.6 3.8 7.5 0.0 4.6 4 1 2 6 6 6 1 non-SMC mitotic condensation complex subunit 1 Dopey_N PF04118.14 EKX72597.1 - 0.012 14.7 0.5 9.8 5.2 0.0 3.2 3 0 0 3 3 3 0 Dopey, N-terminal Vac14_Fab1_bd PF12755.7 EKX72597.1 - 0.018 15.7 0.0 0.39 11.3 0.0 2.9 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region NUC173 PF08161.12 EKX72597.1 - 0.026 14.2 0.0 2.7 7.6 0.0 3.5 3 0 0 3 3 3 0 NUC173 domain UME PF08064.13 EKX72597.1 - 0.4 10.6 2.7 31 4.6 0.0 4.1 5 0 0 5 5 5 0 UME (NUC010) domain DNA_methylase PF00145.17 EKX72598.1 - 3.3e-13 49.7 0.7 9.8e-07 28.4 0.0 4.8 3 1 0 3 3 3 3 C-5 cytosine-specific DNA methylase Cons_hypoth95 PF03602.15 EKX72598.1 - 0.076 12.6 0.0 16 5.1 0.0 3.0 3 0 0 3 3 3 0 Conserved hypothetical protein 95 MethyltransfD12 PF02086.15 EKX72598.1 - 0.18 11.4 0.9 0.36 10.5 0.0 1.9 2 1 1 3 3 3 0 D12 class N6 adenine-specific DNA methyltransferase DUF4602 PF15375.6 EKX72598.1 - 0.24 11.7 0.0 0.41 11.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4602) Prp19 PF08606.11 EKX72601.1 - 6.3e-30 103.0 0.8 1.4e-29 101.8 0.8 1.6 1 0 0 1 1 1 1 Prp19/Pso4-like WD40 PF00400.32 EKX72601.1 - 1.1e-16 60.9 14.1 0.00024 21.8 0.2 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKX72601.1 - 1.9e-07 31.3 0.0 0.079 13.3 0.0 5.2 3 1 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain U-box PF04564.15 EKX72601.1 - 1.8e-05 24.8 0.0 4e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 U-box domain Hira PF07569.11 EKX72601.1 - 0.041 13.6 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 TUP1-like enhancer of split HAUS-augmin3 PF14932.6 EKX72601.1 - 2.8 7.5 7.0 4.5 6.8 0.1 2.6 3 0 0 3 3 3 0 HAUS augmin-like complex subunit 3 FAINT PF04385.15 EKX72602.1 - 6.8e-11 42.1 1.3 1.4e-05 25.0 0.0 3.1 2 1 0 2 2 2 2 Domain of unknown function, DUF529 Hydrolase_3 PF08282.12 EKX72603.1 - 2.2e-32 112.8 0.0 3.1e-32 112.3 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EKX72603.1 - 5.9e-05 22.7 0.0 0.23 10.9 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EKX72603.1 - 0.06 13.6 0.0 0.53 10.5 0.0 2.0 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase HAD PF12710.7 EKX72603.1 - 0.1 13.0 0.0 0.29 11.5 0.0 1.8 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase FAINT PF04385.15 EKX72604.1 - 0.00024 21.1 3.7 0.0023 18.0 0.0 3.2 4 0 0 4 4 4 2 Domain of unknown function, DUF529 Elf1 PF05129.13 EKX72605.1 - 0.016 15.3 0.4 0.035 14.2 0.4 1.6 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like DUF4762 PF15959.5 EKX72605.1 - 0.081 12.9 0.2 0.081 12.9 0.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4762) DEAD PF00270.29 EKX72606.1 - 4e-33 114.7 0.4 7.8e-33 113.7 0.4 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKX72606.1 - 4.3e-24 85.0 0.3 4e-23 81.9 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKX72606.1 - 0.00014 21.9 0.0 0.00028 20.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EKX72606.1 - 0.018 15.3 0.8 0.12 12.6 0.5 2.5 1 1 0 1 1 1 0 AAA domain T4SS-DNA_transf PF02534.14 EKX72606.1 - 0.019 13.8 0.0 0.039 12.8 0.0 1.5 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer Urocanase PF01175.18 EKX72606.1 - 0.1 12.2 0.1 0.2 11.3 0.1 1.4 1 0 0 1 1 1 0 Urocanase Rossmann-like domain Sigma70_r1_1 PF03979.14 EKX72606.1 - 1.6 8.9 3.9 1.3 9.1 0.5 2.5 3 0 0 3 3 3 0 Sigma-70 factor, region 1.1 Mnd1 PF03962.15 EKX72606.1 - 2.1 8.7 4.1 3.7 7.9 0.1 3.0 3 0 0 3 3 3 0 Mnd1 HTH domain IMPDH PF00478.25 EKX72607.1 - 5.6e-126 420.2 2.3 6.4e-126 420.0 2.3 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EKX72607.1 - 1.3e-11 44.5 0.5 2.3e-06 27.2 0.5 2.6 2 0 0 2 2 2 2 Nitronate monooxygenase CBS PF00571.28 EKX72607.1 - 5.3e-10 39.6 0.3 2.2e-05 24.8 0.1 3.2 2 1 0 2 2 2 2 CBS domain FMN_dh PF01070.18 EKX72607.1 - 6e-09 35.4 2.2 1.2e-07 31.1 2.3 2.6 2 1 0 2 2 2 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 EKX72607.1 - 0.0022 17.2 2.0 0.005 16.0 1.6 1.7 1 1 1 2 2 2 1 Conserved region in glutamate synthase His_biosynth PF00977.21 EKX72607.1 - 0.0045 16.5 0.6 0.078 12.4 0.6 2.4 1 1 0 1 1 1 1 Histidine biosynthesis protein DHO_dh PF01180.21 EKX72607.1 - 0.026 13.7 3.4 0.054 12.7 0.7 2.2 1 1 1 2 2 2 0 Dihydroorotate dehydrogenase ThiG PF05690.14 EKX72607.1 - 0.051 12.9 1.1 0.11 11.8 0.8 1.7 1 1 0 1 1 1 0 Thiazole biosynthesis protein ThiG B12-binding PF02310.19 EKX72607.1 - 0.15 12.1 0.1 0.38 10.8 0.0 1.7 2 0 0 2 2 2 0 B12 binding domain G3P_antiterm PF04309.12 EKX72607.1 - 0.16 11.4 0.3 2.4 7.5 0.1 2.8 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator FAINT PF04385.15 EKX72608.1 - 2.4e-19 69.2 13.6 5.6e-06 26.3 0.8 4.9 4 0 0 4 4 4 4 Domain of unknown function, DUF529 DUF2510 PF10708.9 EKX72608.1 - 0.069 12.9 0.6 1.8 8.4 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2510) DUF4758 PF15950.5 EKX72608.1 - 9.6 6.5 8.3 0.46 10.8 1.3 2.2 2 0 0 2 2 2 0 Putative sperm flagellar membrane protein Acetone_carb_G PF08882.11 EKX72609.1 - 0.1 12.7 0.1 0.91 9.7 0.0 2.6 3 0 0 3 3 3 0 Acetone carboxylase gamma subunit WWE PF02825.20 EKX72609.1 - 4.4 8.0 7.2 40 4.9 0.7 3.9 3 0 0 3 3 3 0 WWE domain Cohesin PF00963.18 EKX72611.1 - 0.0054 17.0 0.3 0.011 15.9 0.2 1.5 1 1 0 1 1 1 1 Cohesin domain EMA PF02488.15 EKX72611.1 - 0.099 12.3 3.1 4.8 6.8 0.5 2.3 1 1 0 2 2 2 0 Merozoite Antigen CBM_26 PF16824.5 EKX72614.1 - 0.12 12.5 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 C-terminal carbohydrate-binding module AF-4 PF05110.13 EKX72614.1 - 0.33 9.0 7.0 0.44 8.6 7.0 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein FAINT PF04385.15 EKX72615.1 - 4.1e-25 87.6 8.8 6.9e-08 32.4 0.2 4.9 5 0 0 5 5 5 4 Domain of unknown function, DUF529 CRAL_TRIO PF00650.20 EKX72617.1 - 8.6e-31 106.8 0.0 1.4e-30 106.1 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EKX72617.1 - 0.00012 22.2 0.1 0.00026 21.1 0.1 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain FAINT PF04385.15 EKX72618.1 - 2.2e-25 88.5 8.6 1.6e-06 28.0 0.1 7.0 6 1 1 7 7 7 6 Domain of unknown function, DUF529 Rhodanese PF00581.20 EKX72618.1 - 0.00015 22.2 0.1 0.00038 21.0 0.1 1.7 1 0 0 1 1 1 1 Rhodanese-like domain TypeIII_RM_meth PF12564.8 EKX72618.1 - 0.34 11.1 6.3 7.6 6.7 0.1 3.9 4 0 0 4 4 4 0 Type III restriction/modification enzyme methylation subunit FAINT PF04385.15 EKX72621.1 - 1.2e-06 28.5 0.1 2.6e-06 27.4 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72622.1 - 7.1e-15 54.8 0.0 2.6e-07 30.6 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function, DUF529 DHHC PF01529.20 EKX72623.1 - 1.7e-28 99.3 15.3 1.7e-28 99.3 15.3 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase PocR PF10114.9 EKX72623.1 - 0.073 12.8 3.6 0.13 12.1 3.6 1.3 1 0 0 1 1 1 0 Sensory domain found in PocR DUF4131 PF13567.6 EKX72623.1 - 0.72 9.5 0.0 0.72 9.5 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) DUF2207 PF09972.9 EKX72623.1 - 0.89 8.2 7.9 0.79 8.4 0.1 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Pkinase PF00069.25 EKX72624.1 - 1.8e-62 211.1 0.0 8.2e-62 208.9 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain cNMP_binding PF00027.29 EKX72624.1 - 3.8e-58 193.5 0.5 2.2e-17 62.9 0.0 4.4 4 0 0 4 4 4 4 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 EKX72624.1 - 8.9e-33 113.7 0.0 3.2e-32 111.8 0.0 1.9 3 0 0 3 3 3 1 Protein tyrosine kinase Kinase-like PF14531.6 EKX72624.1 - 3.5e-05 23.3 0.0 5.7e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Cupin_2 PF07883.11 EKX72624.1 - 8.6e-05 22.2 5.1 0.48 10.2 0.1 4.3 4 0 0 4 4 4 1 Cupin domain Pkinase_fungal PF17667.1 EKX72624.1 - 0.00064 18.6 0.0 0.002 17.0 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EKX72624.1 - 0.012 15.5 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EKX72624.1 - 0.027 13.8 0.0 0.051 12.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EKX72624.1 - 0.043 12.8 0.1 0.086 11.8 0.1 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Metallophos PF00149.28 EKX72625.1 - 2.8e-08 34.5 0.6 4.4e-08 33.9 0.6 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Zip PF02535.22 EKX72626.1 - 1.7e-17 63.6 14.3 2.3e-16 60.0 14.3 1.9 1 1 0 1 1 1 1 ZIP Zinc transporter DUF5336 PF17270.2 EKX72626.1 - 4.4 6.9 5.6 1.6 8.3 3.1 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5336) CoA_binding_3 PF13727.6 EKX72626.1 - 7.3 6.6 6.8 7.5 6.5 5.5 1.8 1 1 0 1 1 1 0 CoA-binding domain Ribosomal_L3 PF00297.22 EKX72627.1 - 2.4e-13 49.8 3.1 5.4e-13 48.7 1.6 1.9 1 1 1 2 2 2 1 Ribosomal protein L3 RRM_1 PF00076.22 EKX72628.1 - 6.3e-30 102.8 1.0 3.4e-14 52.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EKX72628.1 - 2.5e-10 40.3 0.1 0.00036 20.6 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EKX72628.1 - 1.1e-05 25.4 0.3 0.025 14.6 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 EKX72628.1 - 0.00035 20.9 0.1 0.27 11.5 0.1 2.4 2 1 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter RL PF17797.1 EKX72628.1 - 0.0032 17.4 0.4 0.89 9.6 0.1 2.4 2 0 0 2 2 2 2 RL domain Peptidase_C25 PF01364.18 EKX72628.1 - 0.054 12.7 1.6 2.1 7.4 0.3 2.2 2 0 0 2 2 2 0 Peptidase family C25 OB_RNB PF08206.11 EKX72628.1 - 0.11 12.1 0.2 12 5.6 0.0 2.6 2 0 0 2 2 2 0 Ribonuclease B OB domain LSM PF01423.22 EKX72629.1 - 5.9e-16 57.9 0.0 7.5e-16 57.6 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EKX72629.1 - 0.0022 18.1 0.0 0.0033 17.5 0.0 1.3 1 1 0 1 1 1 1 Ataxin 2 SM domain BRICHOS PF04089.14 EKX72629.1 - 0.15 12.3 0.0 0.21 11.8 0.0 1.2 1 0 0 1 1 1 0 BRICHOS domain RAP PF08373.10 EKX72630.1 - 0.00037 20.5 1.1 0.001 19.1 0.1 2.3 2 0 0 2 2 2 1 RAP domain Imm6 PF14434.6 EKX72632.1 - 0.062 13.2 0.0 0.28 11.1 0.0 2.2 1 0 0 1 1 1 0 Immunity protein Imm6 Telomerase_RBD PF12009.8 EKX72633.1 - 3e-27 95.4 9.1 2.6e-26 92.3 5.9 2.8 2 0 0 2 2 2 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 EKX72633.1 - 1.6e-10 40.9 0.1 6.3e-05 22.6 0.0 2.8 3 0 0 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) Macro PF01661.21 EKX72634.1 - 6.6e-06 26.2 0.0 1.4e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Macro domain DUF3343 PF11823.8 EKX72634.1 - 0.044 13.2 0.0 0.11 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3343) FYVE PF01363.21 EKX72636.1 - 7.2e-06 26.0 7.3 1.3e-05 25.2 7.3 1.4 1 0 0 1 1 1 1 FYVE zinc finger CLASP_N PF12348.8 EKX72636.1 - 0.054 13.0 2.0 0.091 12.3 2.0 1.4 1 0 0 1 1 1 0 CLASP N terminal C1_2 PF03107.16 EKX72636.1 - 0.075 13.4 6.0 0.25 11.7 6.0 1.9 1 0 0 1 1 1 0 C1 domain C1_1 PF00130.22 EKX72636.1 - 0.34 10.8 10.2 2.3 8.2 1.0 2.4 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) ADD_ATRX PF17981.1 EKX72636.1 - 0.99 9.3 6.6 0.76 9.7 3.6 2.2 2 0 0 2 2 2 0 Cysteine Rich ADD domain Sdh5 PF03937.16 EKX72638.1 - 0.0092 15.9 0.1 0.016 15.1 0.1 1.4 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase AP2 PF00847.20 EKX72639.1 - 3.7e-42 142.3 15.2 8.1e-14 51.6 2.8 3.4 3 0 0 3 3 3 3 AP2 domain Rubredoxin PF00301.20 EKX72640.1 - 0.0015 18.6 3.2 0.094 12.8 3.2 2.3 1 1 0 1 1 1 1 Rubredoxin Zn_Tnp_IS1595 PF12760.7 EKX72640.1 - 0.0054 16.7 0.6 1 9.4 0.1 2.4 2 0 0 2 2 2 1 Transposase zinc-ribbon domain zf-Mss51 PF13824.6 EKX72640.1 - 0.021 14.9 1.9 0.67 10.1 0.2 2.4 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-HIT PF04438.16 EKX72640.1 - 0.035 14.0 1.7 2.3 8.2 0.2 2.8 2 0 0 2 2 2 0 HIT zinc finger Nudix_N_2 PF14803.6 EKX72640.1 - 0.044 13.7 1.0 5.9 6.9 0.0 2.5 2 0 0 2 2 2 0 Nudix N-terminal DUF35_N PF12172.8 EKX72640.1 - 0.068 13.1 3.6 1.1 9.2 0.1 2.7 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Auto_anti-p27 PF06677.12 EKX72640.1 - 0.07 13.3 0.2 9.6 6.5 0.1 2.4 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) HypA PF01155.19 EKX72640.1 - 0.096 12.7 0.3 0.18 11.9 0.3 1.5 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_10 PF10058.9 EKX72640.1 - 0.1 12.4 2.9 6.3 6.6 0.1 2.6 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein DUF1610 PF07754.11 EKX72640.1 - 0.12 12.4 7.3 0.55 10.2 4.9 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF1610) zinc_ribbon_2 PF13240.6 EKX72640.1 - 0.31 10.8 4.9 0.48 10.2 0.6 2.8 2 0 0 2 2 2 0 zinc-ribbon domain Elf1 PF05129.13 EKX72640.1 - 0.42 10.7 6.2 1.2 9.2 0.6 2.9 3 0 0 3 3 3 0 Transcription elongation factor Elf1 like zf-ribbon_3 PF13248.6 EKX72640.1 - 0.46 10.0 4.8 0.21 11.1 0.6 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 EKX72640.1 - 0.52 10.5 3.6 1.9 8.7 3.6 2.0 1 1 0 1 1 1 0 Zinc ribbon domain zf-C2H2 PF00096.26 EKX72640.1 - 1.1 9.9 3.6 42 4.9 0.4 3.0 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-RING_7 PF02591.15 EKX72640.1 - 1.6 9.0 5.7 83 3.5 5.7 3.0 1 1 0 1 1 1 0 C4-type zinc ribbon domain Ribonuc_red_lgC PF02867.15 EKX72641.1 - 2.1e-187 623.9 0.0 2.9e-187 623.4 0.0 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 EKX72641.1 - 1e-22 79.9 0.3 6.6e-22 77.3 0.0 2.4 2 0 0 2 2 2 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 EKX72641.1 - 4.2e-11 43.3 0.0 1e-10 42.0 0.0 1.7 1 0 0 1 1 1 1 ATP cone domain Nse4-Nse3_bdg PF15412.6 EKX72642.1 - 0.078 13.1 0.0 19 5.5 0.0 2.7 2 0 0 2 2 2 0 Binding domain of Nse4/EID3 to Nse3-MAGE PNPase PF03726.14 EKX72642.1 - 0.23 12.0 1.3 1.4 9.4 0.1 2.8 2 0 0 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain CLP_protease PF00574.23 EKX72643.1 - 1.3e-38 132.7 0.0 5.2e-38 130.7 0.0 1.7 1 1 0 1 1 1 1 Clp protease IF2_N PF04760.15 EKX72643.1 - 0.01 15.6 2.0 0.012 15.4 0.4 2.0 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region HIT PF01230.23 EKX72644.1 - 1e-19 71.0 0.1 2.3e-19 69.9 0.0 1.5 2 0 0 2 2 2 1 HIT domain DcpS_C PF11969.8 EKX72644.1 - 2.1e-06 28.2 0.0 3.9e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding MFS_1 PF07690.16 EKX72645.1 - 2.4e-16 59.6 18.9 2.4e-16 59.6 18.9 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily PgaD PF13994.6 EKX72645.1 - 0.72 9.9 3.0 13 5.8 0.0 3.3 3 1 1 4 4 4 0 PgaD-like protein Sld5 PF05916.11 EKX72646.1 - 2.3e-08 34.4 0.0 8.7e-08 32.6 0.0 1.8 1 1 1 2 2 2 1 GINS complex protein UQ_con PF00179.26 EKX72647.1 - 9.3e-44 148.5 0.0 1.1e-43 148.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EKX72647.1 - 0.0097 15.6 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EKX72647.1 - 0.15 12.3 0.5 0.25 11.7 0.5 1.7 1 1 0 1 1 1 0 RWD domain Pyr_redox_2 PF07992.14 EKX72648.1 - 1.1e-35 123.3 0.0 1.4e-35 122.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EKX72648.1 - 1.2e-07 32.1 0.0 3.9e-07 30.5 0.0 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DUF378 PF04070.12 EKX72648.1 - 0.067 13.1 1.5 0.18 11.7 1.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF378) Ank_2 PF12796.7 EKX72649.1 - 1.7e-24 86.2 2.9 1.6e-14 54.3 0.2 3.6 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EKX72649.1 - 1.3e-18 65.1 0.1 8.7e-05 22.6 0.1 5.8 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.6 EKX72649.1 - 1.3e-16 60.7 3.5 2.7e-11 43.8 0.1 4.8 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EKX72649.1 - 5.2e-12 45.6 0.6 0.0022 18.3 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EKX72649.1 - 8.8e-12 45.0 0.1 1.2e-07 31.9 0.0 3.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) BSD PF03909.17 EKX72649.1 - 0.052 13.6 0.1 0.2 11.7 0.1 2.0 1 0 0 1 1 1 0 BSD domain DUF2183 PF09949.9 EKX72650.1 - 7.5e-06 26.2 0.0 3.3e-05 24.1 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2183) Lzipper-MIP1 PF14389.6 EKX72650.1 - 0.095 13.0 0.2 0.28 11.5 0.2 1.7 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 TPT PF03151.16 EKX72651.1 - 5.7e-86 288.5 22.6 6.6e-86 288.3 22.6 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EKX72651.1 - 2.5e-06 27.7 31.7 6.6e-05 23.1 15.9 2.4 2 0 0 2 2 2 2 EamA-like transporter family RCC1 PF00415.18 EKX72652.1 - 1.4e-109 358.6 43.4 9.3e-13 48.6 0.1 15.5 14 2 0 14 14 14 13 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EKX72652.1 - 8.3e-50 165.7 86.5 5.7e-08 32.4 1.1 14.5 14 1 0 14 14 14 10 Regulator of chromosome condensation (RCC1) repeat Hira PF07569.11 EKX72652.1 - 0.00067 19.4 1.8 29 4.3 0.0 5.2 5 1 0 5 5 5 2 TUP1-like enhancer of split DUF4213 PF13938.6 EKX72652.1 - 0.026 14.8 0.2 3.2 8.1 0.0 3.6 3 0 0 3 3 3 0 Putative heavy-metal chelation DEAD PF00270.29 EKX72653.1 - 4.5e-49 166.6 0.0 8.3e-49 165.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKX72653.1 - 1.1e-27 96.6 0.3 7.3e-27 93.9 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain THP2 PF09432.10 EKX72653.1 - 0.019 15.0 1.1 0.053 13.6 1.1 1.7 1 0 0 1 1 1 0 Tho complex subunit THP2 UK PF02512.14 EKX72653.1 - 0.1 13.1 2.5 0.44 11.1 1.8 2.3 2 0 0 2 2 2 0 Virulence determinant DEAD PF00270.29 EKX72655.1 - 1.4e-50 171.4 0.0 3e-50 170.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKX72655.1 - 3.8e-34 117.4 0.1 2.3e-33 114.9 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKX72655.1 - 0.0062 16.6 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 EKX72655.1 - 0.0065 15.3 1.4 0.023 13.5 0.0 2.6 3 1 0 3 3 3 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DUF3885 PF13021.6 EKX72655.1 - 0.051 13.7 0.1 0.16 12.1 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3885) PhoLip_ATPase_C PF16212.5 EKX72656.1 - 3.9e-60 203.7 31.9 3.9e-60 203.7 31.9 3.8 4 0 0 4 4 4 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EKX72656.1 - 3.3e-17 61.9 3.9 3.3e-17 61.9 3.9 2.1 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EKX72656.1 - 3.1e-09 37.4 0.0 0.00034 21.0 0.0 3.2 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EKX72656.1 - 2e-08 33.9 8.5 6.3e-07 29.1 0.0 3.0 3 0 0 3 3 3 2 E1-E2 ATPase Hydrolase_3 PF08282.12 EKX72656.1 - 0.016 15.0 0.0 0.095 12.4 0.0 2.3 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EKX72656.1 - 0.13 12.4 0.0 0.27 11.4 0.0 1.6 1 0 0 1 1 1 0 Cation transport ATPase (P-type) Adeno_GP19K PF04881.13 EKX72657.1 - 0.022 14.7 0.2 7.1 6.6 0.0 2.8 3 0 0 3 3 3 0 Adenovirus GP19K Claudin_2 PF13903.6 EKX72657.1 - 0.024 14.4 1.8 0.044 13.5 0.0 2.3 1 1 2 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction Hydrolase_3 PF08282.12 EKX72658.1 - 5.9e-41 140.9 0.0 7.8e-41 140.5 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EKX72658.1 - 0.00011 22.6 0.0 0.00035 20.9 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EKX72658.1 - 0.00018 21.2 0.0 0.12 11.9 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase HAD PF12710.7 EKX72658.1 - 0.00093 19.6 0.0 0.41 11.0 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase POTRA_1 PF08478.10 EKX72658.1 - 0.073 13.4 0.0 1.1 9.5 0.0 2.7 3 0 0 3 3 3 0 POTRA domain, FtsQ-type FAINT PF04385.15 EKX72659.1 - 0.0031 17.5 1.0 1.2 9.2 0.1 2.5 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Clathrin PF00637.20 EKX72660.1 - 7.3e-140 460.3 42.9 2.6e-27 95.4 0.2 8.4 8 0 0 8 8 8 8 Region in Clathrin and VPS Clathrin_H_link PF13838.6 EKX72660.1 - 7.3e-25 86.7 0.6 1.2e-23 82.8 0.0 2.9 2 0 0 2 2 2 1 Clathrin-H-link Clathrin_propel PF01394.20 EKX72660.1 - 8.5e-06 25.8 0.1 0.087 13.2 0.0 3.8 3 0 0 3 3 3 2 Clathrin propeller repeat TPR_8 PF13181.6 EKX72660.1 - 0.00019 21.4 13.1 0.013 15.7 0.1 6.9 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_2 PF07719.17 EKX72660.1 - 0.076 13.2 0.1 0.076 13.2 0.1 7.2 8 1 1 9 9 9 0 Tetratricopeptide repeat TPR_7 PF13176.6 EKX72660.1 - 0.37 10.9 5.3 73 3.7 0.1 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EKX72660.1 - 1.8 8.8 15.6 2.5 8.4 0.2 6.4 5 1 1 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 Vps39_1 PF10366.9 EKX72660.1 - 9.2 6.6 13.5 1.9 8.8 0.1 5.1 5 0 0 5 5 5 0 Vacuolar sorting protein 39 domain 1 Ssl1 PF04056.14 EKX72661.1 - 7.9e-54 182.4 0.0 1.1e-53 182.0 0.0 1.1 1 0 0 1 1 1 1 Ssl1-like VWA_2 PF13519.6 EKX72661.1 - 5.8e-09 36.6 0.0 9.5e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain C1_4 PF07975.12 EKX72661.1 - 6e-06 26.4 19.9 1.4e-05 25.2 11.4 2.7 2 0 0 2 2 2 2 TFIIH C1-like domain VWA PF00092.28 EKX72661.1 - 0.00016 22.0 0.0 0.00025 21.4 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Tfb4 PF03850.14 EKX72661.1 - 0.00029 20.4 0.2 0.00029 20.4 0.2 1.8 2 0 0 2 2 2 1 Transcription factor Tfb4 zf-U1 PF06220.12 EKX72661.1 - 0.037 13.8 4.3 0.13 12.1 4.3 1.9 1 0 0 1 1 1 0 U1 zinc finger DZR PF12773.7 EKX72661.1 - 2.1 8.4 29.1 86 3.3 19.7 3.2 1 1 1 2 2 2 0 Double zinc ribbon PRP1_N PF06424.12 EKX72662.1 - 2.2 8.6 5.9 4.5 7.6 5.9 1.5 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal SF3A3 PF16837.5 EKX72663.1 - 0.75 10.4 5.9 17 6.0 0.0 4.4 3 0 0 3 3 3 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 Myb_DNA-bind_6 PF13921.6 EKX72663.1 - 8.1 6.8 9.1 22 5.4 0.2 4.3 4 0 0 4 4 4 0 Myb-like DNA-binding domain Ribosomal_L34e PF01199.18 EKX72667.1 - 3e-38 130.0 7.3 3e-38 130.0 7.3 1.9 2 1 0 2 2 2 1 Ribosomal protein L34e RRM_occluded PF16842.5 EKX72667.1 - 0.34 10.8 1.5 0.42 10.5 0.5 1.5 2 0 0 2 2 2 0 Occluded RNA-recognition motif tRNA-synt_2 PF00152.20 EKX72668.1 - 7.5e-78 261.8 0.0 1e-77 261.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EKX72668.1 - 2.4e-09 37.0 0.0 4.1e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EKX72668.1 - 4.7e-05 23.0 0.1 0.31 10.5 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA_anti_2 PF13742.6 EKX72668.1 - 0.074 13.3 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain AAA PF00004.29 EKX72669.1 - 1.2e-90 300.7 0.0 7.9e-45 152.5 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EKX72669.1 - 8.7e-28 95.9 3.2 5.6e-13 48.5 0.0 3.1 3 0 0 3 3 3 2 AAA+ lid domain RuvB_N PF05496.12 EKX72669.1 - 7.2e-15 55.1 0.0 4.4e-06 26.5 0.0 2.9 4 0 0 4 4 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EKX72669.1 - 6.7e-14 52.4 0.0 3.8e-07 30.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EKX72669.1 - 9.5e-13 48.9 0.1 0.00018 22.0 0.0 4.1 2 2 1 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 EKX72669.1 - 2.9e-11 43.5 0.0 0.00013 21.9 0.0 3.6 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EKX72669.1 - 9.2e-10 38.2 0.0 0.00032 20.0 0.0 2.6 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_33 PF13671.6 EKX72669.1 - 1.2e-09 38.5 0.0 0.00023 21.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 EKX72669.1 - 1.8e-09 37.7 0.0 0.0013 18.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EKX72669.1 - 4.9e-09 36.6 0.2 0.081 13.2 0.0 3.8 2 2 1 3 3 3 2 AAA domain CDC48_N PF02359.18 EKX72669.1 - 5.8e-08 32.8 0.6 1.5e-07 31.5 0.6 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RNA_helicase PF00910.22 EKX72669.1 - 4.3e-07 30.3 0.0 0.015 15.7 0.0 2.8 2 0 0 2 2 2 2 RNA helicase IstB_IS21 PF01695.17 EKX72669.1 - 6.7e-07 29.2 0.1 0.03 14.1 0.1 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.6 EKX72669.1 - 1e-06 29.3 0.0 0.094 13.3 0.0 2.9 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 EKX72669.1 - 1.1e-06 28.2 0.9 0.031 13.7 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 EKX72669.1 - 1.4e-06 28.9 0.1 0.087 13.3 0.0 2.9 3 0 0 3 3 2 2 ABC transporter Viral_helicase1 PF01443.18 EKX72669.1 - 1.9e-06 27.8 0.0 0.0039 17.0 0.0 2.4 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.6 EKX72669.1 - 5e-06 26.9 0.0 0.077 13.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 EKX72669.1 - 6.3e-06 26.2 0.4 0.25 11.2 0.0 3.3 3 0 0 3 3 3 2 NACHT domain TsaE PF02367.17 EKX72669.1 - 6.3e-06 26.2 0.0 0.13 12.2 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 EKX72669.1 - 9.4e-06 26.1 0.1 0.24 11.8 0.0 3.1 3 0 0 3 3 2 2 AAA domain Vps4_C PF09336.10 EKX72669.1 - 3.2e-05 23.8 0.0 0.00019 21.3 0.0 2.3 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain Zeta_toxin PF06414.12 EKX72669.1 - 3.3e-05 23.3 0.0 0.13 11.5 0.1 2.6 2 0 0 2 2 2 2 Zeta toxin AAA_25 PF13481.6 EKX72669.1 - 3.9e-05 23.3 0.2 1.7 8.2 0.0 3.6 2 1 1 3 3 3 2 AAA domain AAA_3 PF07726.11 EKX72669.1 - 4.8e-05 23.2 0.0 0.16 11.8 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Parvo_NS1 PF01057.17 EKX72669.1 - 6.2e-05 22.2 0.2 0.032 13.3 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 Sigma54_activ_2 PF14532.6 EKX72669.1 - 6.2e-05 23.1 0.0 0.56 10.3 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain Sigma54_activat PF00158.26 EKX72669.1 - 0.00017 21.3 0.1 1.4 8.6 0.0 3.6 3 1 0 3 3 2 2 Sigma-54 interaction domain PhoH PF02562.16 EKX72669.1 - 0.00023 20.7 0.0 0.46 9.9 0.0 2.6 2 0 0 2 2 2 2 PhoH-like protein NB-ARC PF00931.22 EKX72669.1 - 0.00025 20.3 0.0 0.38 9.9 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain AAA_7 PF12775.7 EKX72669.1 - 0.00038 20.0 0.0 0.21 11.1 0.0 2.6 2 1 0 2 2 2 1 P-loop containing dynein motor region Bac_DnaA PF00308.18 EKX72669.1 - 0.00053 19.9 0.0 1.5 8.7 0.0 2.5 2 0 0 2 2 2 2 Bacterial dnaA protein ATPase PF06745.13 EKX72669.1 - 0.0012 18.2 0.1 3.1 7.1 0.1 2.9 2 1 0 2 2 2 2 KaiC Molydop_binding PF01568.21 EKX72669.1 - 0.0013 18.7 0.0 0.0042 17.1 0.1 1.8 2 0 0 2 2 1 1 Molydopterin dinucleotide binding domain DUF2075 PF09848.9 EKX72669.1 - 0.0016 17.7 0.0 0.61 9.3 0.0 2.5 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_23 PF13476.6 EKX72669.1 - 0.0024 18.4 0.1 1 9.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EKX72669.1 - 0.003 17.9 1.4 3 8.1 0.3 3.4 3 1 1 4 4 3 1 AAA domain AAA_11 PF13086.6 EKX72669.1 - 0.003 17.4 0.0 2.8 7.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 EKX72669.1 - 0.0033 17.4 0.1 0.85 9.5 0.0 3.3 3 2 1 4 4 3 1 ATPase domain predominantly from Archaea Hydin_ADK PF17213.3 EKX72669.1 - 0.0035 17.7 1.5 0.33 11.2 0.2 3.1 3 0 0 3 3 3 1 Hydin Adenylate kinase-like domain AAA_24 PF13479.6 EKX72669.1 - 0.0053 16.5 0.1 2 8.1 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EKX72669.1 - 0.0067 16.2 0.2 2 8.1 0.2 2.5 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 EKX72669.1 - 0.012 15.5 0.4 17 5.3 0.0 4.2 4 1 1 5 5 3 0 NTPase DUF815 PF05673.13 EKX72669.1 - 0.013 14.6 0.0 0.48 9.5 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF815) Rad17 PF03215.15 EKX72669.1 - 0.015 15.2 0.0 1.2 9.1 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain Cytidylate_kin PF02224.18 EKX72669.1 - 0.031 14.0 0.1 3.8 7.2 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase ResIII PF04851.15 EKX72669.1 - 0.04 13.9 0.0 14 5.6 0.0 2.7 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit Cytidylate_kin2 PF13189.6 EKX72669.1 - 0.045 13.9 0.0 14 5.8 0.0 2.7 2 0 0 2 2 2 0 Cytidylate kinase-like family KAP_NTPase PF07693.14 EKX72669.1 - 0.048 12.9 0.2 3.4 6.8 0.0 2.8 3 1 0 3 3 2 0 KAP family P-loop domain CPT PF07931.12 EKX72669.1 - 0.084 12.7 0.0 3.6 7.4 0.0 2.7 2 1 1 3 3 2 0 Chloramphenicol phosphotransferase-like protein SKI PF01202.22 EKX72669.1 - 0.094 12.8 0.1 10 6.3 0.0 2.6 2 0 0 2 2 2 0 Shikimate kinase ATP-synt_ab PF00006.25 EKX72669.1 - 0.1 12.2 0.1 20 4.8 0.0 3.0 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain T2SSE PF00437.20 EKX72669.1 - 0.11 11.6 0.0 15 4.6 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein Zot PF05707.12 EKX72669.1 - 0.15 11.7 0.0 19 4.8 0.0 3.2 2 1 1 3 3 3 0 Zonular occludens toxin (Zot) Glycos_transf_1 PF00534.20 EKX72670.1 - 8.3e-07 28.7 0.0 1.6e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EKX72670.1 - 4.2e-05 24.0 0.0 8.7e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EKX72670.1 - 0.0025 17.9 0.0 0.0048 16.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 DNA_mis_repair PF01119.19 EKX72671.1 - 1.7e-24 85.8 0.1 3.6e-24 84.7 0.1 1.6 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain MutL_C PF08676.11 EKX72671.1 - 9.8e-17 61.1 0.0 1.3e-15 57.5 0.0 2.6 1 1 0 1 1 1 1 MutL C terminal dimerisation domain HATPase_c_3 PF13589.6 EKX72671.1 - 4.9e-10 39.4 0.2 1e-09 38.3 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EKX72671.1 - 3.7e-07 30.6 0.0 1e-06 29.2 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Fe_dep_repr_C PF02742.15 EKX72671.1 - 0.12 12.5 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 Iron dependent repressor, metal binding and dimerisation domain Nod1 PF17114.5 EKX72672.1 - 0.052 13.7 0.3 0.052 13.7 0.3 3.4 3 0 0 3 3 3 0 Gef2-related medial cortical node protein Nod1 Neuralized PF07177.12 EKX72672.1 - 0.17 11.9 0.0 0.34 10.9 0.0 1.4 1 0 0 1 1 1 0 Neuralized UCH PF00443.29 EKX72673.1 - 3.4e-42 144.7 2.7 6.6e-42 143.8 2.7 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 EKX72673.1 - 3.7e-10 39.8 0.4 6.1e-08 32.6 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin-specific protease C-terminal UCH_1 PF13423.6 EKX72673.1 - 5.1e-10 39.4 7.3 1.1e-08 35.1 7.3 2.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ribosomal_S21 PF01165.20 EKX72674.1 - 0.04 13.6 1.5 0.04 13.6 1.5 2.2 3 1 0 3 3 3 0 Ribosomal protein S21 Methyltr_RsmB-F PF01189.17 EKX72675.1 - 2.5e-24 86.0 0.0 8.8e-24 84.3 0.0 1.9 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.6 EKX72675.1 - 3.2e-06 27.0 0.1 1.1e-05 25.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EKX72675.1 - 0.00057 20.5 0.1 0.0069 17.1 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.6 EKX72675.1 - 0.0092 15.8 0.0 0.12 12.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 EKX72675.1 - 0.014 15.5 0.0 0.04 14.0 0.0 1.6 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_5 PF01795.19 EKX72675.1 - 0.029 13.9 0.0 5 6.5 0.0 2.2 1 1 1 2 2 2 0 MraW methylase family POR PF01558.18 EKX72675.1 - 0.033 14.3 0.0 0.066 13.3 0.0 1.4 1 0 0 1 1 1 0 Pyruvate ferredoxin/flavodoxin oxidoreductase UcrQ PF02939.16 EKX72675.1 - 0.13 12.3 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 UcrQ family Vps51 PF08700.11 EKX72676.1 - 1.6e-14 53.7 0.5 5.9e-14 51.9 0.5 2.0 1 0 0 1 1 1 1 Vps51/Vps67 Baculo_PEP_C PF04513.12 EKX72676.1 - 7.2 6.7 12.1 4.7 7.3 0.8 3.1 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Vta1 PF04652.16 EKX72677.1 - 2.3e-13 50.3 0.4 7.2e-13 48.7 0.4 1.8 1 1 0 1 1 1 1 Vta1 like Vta1_C PF18097.1 EKX72677.1 - 2.2e-07 30.5 3.1 8.4e-07 28.6 0.3 2.3 2 0 0 2 2 2 1 Vta1 C-terminal domain Nrap_D5 PF17406.2 EKX72677.1 - 0.076 12.8 0.1 0.1 12.4 0.1 1.3 1 0 0 1 1 1 0 Nrap protein PAP/OAS1-like domain 5 Adenine_glyco PF03352.13 EKX72677.1 - 0.085 12.6 0.1 0.47 10.2 0.1 1.9 1 1 1 2 2 2 0 Methyladenine glycosylase Hist_deacetyl PF00850.19 EKX72679.1 - 8.2e-71 239.0 0.0 1.6e-70 238.1 0.0 1.4 1 0 0 1 1 1 1 Histone deacetylase domain Ank_4 PF13637.6 EKX72679.1 - 7.1e-08 32.9 0.5 0.028 15.0 0.3 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EKX72679.1 - 3.1e-05 24.5 0.0 0.59 10.8 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EKX72679.1 - 0.021 15.3 0.3 4 8.3 0.1 3.7 3 0 0 3 3 3 0 Ankyrin repeat Ank_5 PF13857.6 EKX72679.1 - 0.032 14.5 0.0 1.2 9.5 0.0 2.6 2 0 0 2 2 2 0 Ankyrin repeats (many copies) GpcrRhopsn4 PF10192.9 EKX72680.1 - 0.0001 21.8 13.4 0.0001 21.8 13.4 1.8 2 0 0 2 2 2 1 Rhodopsin-like GPCR transmembrane domain HSP20 PF00011.21 EKX72681.1 - 7.7e-10 38.8 0.1 1.1e-09 38.3 0.1 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EKX72681.1 - 2.4e-07 30.2 0.1 4.5e-07 29.3 0.1 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA Beta-Casp PF10996.8 EKX72682.1 - 8.5e-27 93.6 0.0 3.2e-26 91.8 0.0 2.0 2 0 0 2 2 2 1 Beta-Casp domain RMMBL PF07521.12 EKX72682.1 - 1e-18 67.0 0.0 2e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain CPSF73-100_C PF11718.8 EKX72682.1 - 1.3e-18 67.4 4.1 2.1e-18 66.7 4.1 1.4 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Lactamase_B_6 PF16661.5 EKX72682.1 - 6.1e-14 51.9 0.0 1.6e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 EKX72682.1 - 7e-14 52.3 0.1 4e-11 43.3 0.0 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Beta_lactamase3 PF17030.5 EKX72682.1 - 0.00021 20.6 0.0 0.00043 19.6 0.0 1.5 1 0 0 1 1 1 1 Putative beta-lactamase-like family Lactamase_B_2 PF12706.7 EKX72682.1 - 0.00056 19.5 0.0 0.16 11.5 0.0 2.6 3 0 0 3 3 3 2 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EKX72682.1 - 0.047 13.6 0.1 0.21 11.5 0.1 2.0 1 1 0 1 1 1 0 Beta-lactamase superfamily domain DUF410 PF04190.13 EKX72683.1 - 2.9e-45 155.1 0.0 3.3e-45 154.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF410) RTP1_C1 PF10363.9 EKX72683.1 - 0.057 13.6 0.1 0.24 11.6 0.1 2.0 1 1 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 VMA21 PF09446.10 EKX72684.1 - 3e-06 27.2 3.6 4.3e-06 26.7 3.6 1.2 1 0 0 1 1 1 1 VMA21-like domain BPD_transp_1 PF00528.22 EKX72684.1 - 0.03 14.0 2.2 0.038 13.7 2.2 1.1 1 0 0 1 1 1 0 Binding-protein-dependent transport system inner membrane component DUF3215 PF11503.8 EKX72684.1 - 0.066 13.1 0.0 0.14 12.0 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3215) RseC_MucC PF04246.12 EKX72684.1 - 0.079 12.9 0.3 0.095 12.6 0.3 1.2 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC TssN PF17555.2 EKX72684.1 - 0.081 12.3 0.5 0.089 12.2 0.5 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssN Picorna_P3A PF06363.11 EKX72684.1 - 0.11 12.4 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Picornaviridae P3A protein G6PD_C PF02781.16 EKX72685.1 - 1.5e-64 218.0 0.0 3.4e-64 216.8 0.0 1.5 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 EKX72685.1 - 3.3e-39 135.3 0.0 6.9e-39 134.3 0.0 1.5 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Glucosamine_iso PF01182.20 EKX72685.1 - 1.2e-37 130.0 0.0 2e-37 129.3 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase TFIIE_beta PF02186.15 EKX72686.1 - 1.1e-05 25.6 0.1 2.7e-05 24.4 0.1 1.6 1 0 0 1 1 1 1 TFIIE beta subunit core domain SusD-like_3 PF14322.6 EKX72686.1 - 0.048 14.0 0.1 0.084 13.2 0.1 1.5 1 0 0 1 1 1 0 Starch-binding associating with outer membrane MRP-L27 PF09809.9 EKX72687.1 - 0.15 11.9 0.0 0.56 10.1 0.0 1.9 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L27 SET PF00856.28 EKX72689.1 - 6.5e-06 26.6 1.9 1.4e-05 25.5 1.9 1.6 1 1 0 1 1 1 1 SET domain zf-C3HC4_2 PF13923.6 EKX72690.1 - 9.5e-06 25.4 12.9 2.1e-05 24.2 12.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EKX72690.1 - 0.0011 19.0 4.4 0.0011 19.0 4.4 1.9 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EKX72690.1 - 0.013 15.3 13.2 0.028 14.3 13.2 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EKX72690.1 - 0.075 13.4 12.1 0.14 12.5 12.1 1.5 1 0 0 1 1 1 0 Ring finger domain zf-RING_6 PF14835.6 EKX72690.1 - 0.083 12.8 6.7 0.18 11.7 6.7 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_5 PF14634.6 EKX72690.1 - 0.43 10.6 12.3 0.81 9.7 12.3 1.5 1 0 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.6 EKX72690.1 - 2.7 7.9 9.8 5.9 6.8 9.8 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EKX72690.1 - 3.6 7.8 12.2 9.2 6.5 12.2 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING RLL PF10036.9 EKX72691.1 - 5.6e-25 88.7 1.8 1.9e-23 83.6 1.8 2.1 1 1 0 1 1 1 1 RNA transcription, translation and transport factor protein Laminin_B PF00052.18 EKX72691.1 - 0.067 13.1 0.0 0.097 12.6 0.0 1.3 1 0 0 1 1 1 0 Laminin B (Domain IV) PUB PF09409.10 EKX72692.1 - 6.2e-09 35.7 0.3 1.5e-08 34.5 0.3 1.7 1 0 0 1 1 1 1 PUB domain DNA_ligase_A_M PF01068.21 EKX72693.1 - 3.7e-56 190.0 0.0 5.9e-56 189.4 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EKX72693.1 - 6.4e-34 117.8 0.2 1e-33 117.1 0.2 1.4 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EKX72693.1 - 3.7e-22 78.8 0.0 6.5e-22 78.0 0.0 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 EKX72693.1 - 9e-05 22.8 0.0 0.00015 22.2 0.0 1.3 1 0 0 1 1 1 1 RNA ligase FAINT PF04385.15 EKX72694.1 - 2e-10 40.6 0.2 3.1e-10 40.0 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 DUF4028 PF13220.6 EKX72694.1 - 0.078 12.8 0.2 0.14 12.0 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4028) CcmH PF03918.14 EKX72695.1 - 0.11 11.8 0.2 0.18 11.1 0.2 1.2 1 0 0 1 1 1 0 Cytochrome C biogenesis protein zf-C2H2_2 PF12756.7 EKX72695.1 - 0.2 12.0 0.7 4.1 7.8 0.0 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) CorA PF01544.18 EKX72696.1 - 1.4e-05 24.5 1.2 2.7e-05 23.6 0.1 1.8 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein PTS_EIIC_2 PF13303.6 EKX72696.1 - 0.037 13.1 2.1 0.049 12.7 2.1 1.1 1 0 0 1 1 1 0 Phosphotransferase system, EIIC DRAT PF07357.11 EKX72696.1 - 0.047 12.9 0.0 0.075 12.2 0.0 1.2 1 0 0 1 1 1 0 Dinitrogenase reductase ADP-ribosyltransferase (DRAT) Elf1 PF05129.13 EKX72697.1 - 1.7e-23 82.5 1.6 2.8e-23 81.7 1.6 1.4 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like YABBY PF04690.13 EKX72697.1 - 0.072 13.6 0.4 0.11 13.1 0.4 1.2 1 0 0 1 1 1 0 YABBY protein MFS_1 PF07690.16 EKX72698.1 - 2.6e-20 72.6 13.8 2.6e-20 72.6 13.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2484 PF10658.9 EKX72698.1 - 0.86 10.0 4.4 3.6 8.0 0.3 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2484) FAINT PF04385.15 EKX72700.1 - 5.6e-09 35.9 0.8 2.9e-08 33.6 0.1 2.1 1 1 2 3 3 3 1 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72701.1 - 8.1e-49 163.6 8.7 1.3e-08 34.8 0.2 6.4 6 0 0 6 6 6 6 Domain of unknown function, DUF529 EMA PF02488.15 EKX72701.1 - 0.00023 20.9 8.1 0.11 12.2 0.1 3.5 3 0 0 3 3 3 2 Merozoite Antigen Trp_DMAT PF11991.8 EKX72701.1 - 0.018 14.5 0.0 4.9 6.5 0.0 2.3 2 0 0 2 2 2 0 Tryptophan dimethylallyltransferase DUF5582 PF17819.1 EKX72701.1 - 0.036 14.5 2.8 7.2 7.0 0.0 3.3 4 0 0 4 4 4 0 Family of unknown function (DUF5582) Med22 PF06179.12 EKX72702.1 - 3.1e-05 24.1 0.4 3.7e-05 23.9 0.4 1.1 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex Rota_NS6 PF04866.12 EKX72702.1 - 0.059 13.6 0.3 0.082 13.1 0.3 1.3 1 0 0 1 1 1 0 Rotavirus non-structural protein 6 Med6 PF04934.14 EKX72703.1 - 0.00014 21.6 0.0 0.24 11.2 0.0 2.3 2 0 0 2 2 2 2 MED6 mediator sub complex component LBP_BPI_CETP PF01273.25 EKX72704.1 - 0.055 13.1 0.1 0.15 11.6 0.1 1.7 1 0 0 1 1 1 0 LBP / BPI / CETP family, N-terminal domain Sua5_yciO_yrdC PF01300.18 EKX72705.1 - 4.4e-20 71.9 0.0 5.3e-20 71.7 0.0 1.1 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 EKX72707.1 - 3.1e-16 60.2 0.0 5e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding Sua5_yciO_yrdC PF01300.18 EKX72707.1 - 1.2e-15 57.5 0.0 2.3e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 Telomere recombination zf-ribbon_3 PF13248.6 EKX72707.1 - 0.019 14.4 1.6 0.043 13.2 1.6 1.6 1 0 0 1 1 1 0 zinc-ribbon domain SRP14 PF02290.15 EKX72708.1 - 7.4e-06 26.2 0.0 8.6e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle 14kD protein DUF2695 PF10905.8 EKX72709.1 - 0.018 15.2 0.4 1.6 9.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2695) AAA_18 PF13238.6 EKX72711.1 - 0.3 11.6 4.8 0.48 11.0 4.2 1.8 1 1 0 1 1 1 0 AAA domain DUF5423 PF17461.2 EKX72712.1 - 0.22 10.3 1.2 0.34 9.7 1.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5423) Collagen PF01391.18 EKX72712.1 - 0.45 10.3 14.9 1.6 8.5 14.9 1.9 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Hydrolase_4 PF12146.8 EKX72713.1 - 3.5e-19 69.0 0.1 8.6e-18 64.5 0.0 2.9 2 1 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX72713.1 - 1.3e-15 57.2 5.0 5.2e-07 29.6 0.2 3.9 4 0 0 4 4 4 3 Domain of unknown function, DUF529 Abhydrolase_6 PF12697.7 EKX72713.1 - 8.7e-05 23.2 0.0 0.00035 21.2 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EKX72713.1 - 0.00027 20.5 0.0 0.0035 16.9 0.0 2.4 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 EKX72713.1 - 0.0018 18.1 0.0 0.5 10.1 0.0 2.5 3 0 0 3 3 3 2 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 EKX72713.1 - 0.012 15.3 0.2 0.23 11.1 0.3 2.7 2 1 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 EKX72713.1 - 0.13 12.1 0.0 1 9.2 0.0 2.3 3 0 0 3 3 3 0 alpha/beta hydrolase fold VCBS PF13517.6 EKX72714.1 - 0.17 12.5 0.5 0.65 10.6 0.1 2.2 2 0 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella ABC_tran PF00005.27 EKX72715.1 - 3.5e-29 102.1 0.0 2.6e-17 63.6 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_29 PF13555.6 EKX72715.1 - 2.1e-05 24.2 1.3 0.11 12.2 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EKX72715.1 - 6.8e-05 23.3 0.0 0.05 14.0 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EKX72715.1 - 0.00014 21.8 0.6 0.024 14.6 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 EKX72715.1 - 0.00015 21.7 0.4 0.4 10.4 0.1 3.0 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 EKX72715.1 - 0.0011 18.7 0.1 0.59 9.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain MeaB PF03308.16 EKX72715.1 - 0.0026 16.8 0.7 0.022 13.8 0.1 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 EKX72715.1 - 0.0026 17.1 0.3 0.89 8.8 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin DUF87 PF01935.17 EKX72715.1 - 0.0032 17.6 3.5 0.02 15.0 0.3 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain DnaB_C PF03796.15 EKX72715.1 - 0.0035 16.7 0.0 0.48 9.7 0.0 2.2 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_18 PF13238.6 EKX72715.1 - 0.0036 17.8 0.2 1.7 9.2 0.1 2.6 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 EKX72715.1 - 0.0071 15.7 0.2 1.8 7.9 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family MMR_HSR1 PF01926.23 EKX72715.1 - 0.01 15.9 0.2 0.21 11.7 0.1 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase Dynamin_N PF00350.23 EKX72715.1 - 0.011 15.8 2.1 1.3 9.1 0.2 2.5 2 0 0 2 2 2 0 Dynamin family AAA_23 PF13476.6 EKX72715.1 - 0.019 15.5 1.2 4.4 7.8 0.2 2.6 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EKX72715.1 - 0.021 15.1 0.1 2.1 8.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 EKX72715.1 - 0.031 13.7 1.6 0.29 10.5 0.1 2.7 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain T2SSE PF00437.20 EKX72715.1 - 0.068 12.2 0.6 7.3 5.6 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein ATP_bind_1 PF03029.17 EKX72715.1 - 0.081 12.7 0.3 15 5.2 0.1 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_25 PF13481.6 EKX72715.1 - 0.16 11.5 0.0 3.5 7.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 EKX72715.1 - 0.17 11.0 0.1 2 7.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 EKX72715.1 - 0.17 12.0 0.2 14 5.9 0.1 2.5 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EKX72715.1 - 0.28 11.1 0.8 24 4.8 0.1 2.6 2 0 0 2 2 2 0 NACHT domain FAINT PF04385.15 EKX72717.1 - 2.7e-10 40.2 3.2 6.7e-06 26.1 0.1 2.6 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Baculo_RING PF05883.11 EKX72717.1 - 0.041 13.9 0.1 0.82 9.7 0.0 2.5 2 0 0 2 2 2 0 Baculovirus U-box/Ring-like domain DUF948 PF06103.11 EKX72717.1 - 0.29 11.4 2.2 0.92 9.8 1.3 2.4 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) AAA_22 PF13401.6 EKX72718.1 - 3.3e-13 50.1 0.0 8.6e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EKX72718.1 - 7.6e-12 45.8 0.0 2.5e-11 44.1 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EKX72718.1 - 9.9e-10 39.1 0.0 1.3e-07 32.2 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_lid_10 PF17872.1 EKX72718.1 - 2.8e-05 24.2 0.4 0.00025 21.1 0.1 2.4 2 0 0 2 2 2 1 AAA lid domain NACHT PF05729.12 EKX72718.1 - 0.0024 17.8 0.0 0.0041 17.1 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Rad17 PF03215.15 EKX72718.1 - 0.0067 16.4 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_19 PF13245.6 EKX72718.1 - 0.0079 16.5 0.2 0.13 12.6 0.3 2.4 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EKX72718.1 - 0.02 14.6 0.0 0.043 13.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain DUF228 PF02989.14 EKX72718.1 - 0.03 14.1 0.1 0.074 12.9 0.1 1.6 1 0 0 1 1 1 0 Lyme disease proteins of unknown function DUF2075 PF09848.9 EKX72718.1 - 0.031 13.5 0.0 0.049 12.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.6 EKX72718.1 - 0.05 13.4 0.3 0.09 12.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain F-box PF00646.33 EKX72718.1 - 0.052 13.4 0.2 0.13 12.2 0.2 1.7 1 0 0 1 1 1 0 F-box domain RNA_helicase PF00910.22 EKX72718.1 - 0.07 13.5 0.1 1.2 9.6 0.1 2.7 2 1 0 2 2 2 0 RNA helicase MeaB PF03308.16 EKX72718.1 - 0.15 11.0 0.2 0.25 10.3 0.2 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB HMG_box PF00505.19 EKX72720.1 - 4.7e-23 81.4 3.4 4.7e-23 81.4 3.4 1.4 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EKX72720.1 - 2.5e-14 53.6 2.9 2.5e-14 53.6 2.9 1.4 2 0 0 2 2 2 1 HMG-box domain HMG_box_5 PF14887.6 EKX72720.1 - 0.0021 18.0 2.8 0.0021 18.0 2.8 1.9 1 1 0 1 1 1 1 HMG (high mobility group) box 5 DUF2582 PF10771.9 EKX72720.1 - 0.051 13.7 0.1 0.096 12.8 0.1 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix domain (DUF2582) YABBY PF04690.13 EKX72720.1 - 0.068 13.7 0.4 0.097 13.2 0.4 1.3 1 0 0 1 1 1 0 YABBY protein FTA4 PF13093.6 EKX72722.1 - 0.01 15.7 2.5 0.01 15.7 2.5 2.8 2 1 1 3 3 3 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 ApoC-I PF04691.12 EKX72722.1 - 1.4 8.9 9.5 1.2 9.1 2.7 2.8 2 0 0 2 2 2 0 Apolipoprotein C-I (ApoC-1) Exonuc_VII_L PF02601.15 EKX72722.1 - 2.4 7.7 9.7 1 8.9 0.3 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit DPM3 PF08285.11 EKX72722.1 - 2.8 8.2 4.4 1.3 9.3 0.4 2.5 2 0 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) FapA PF03961.13 EKX72722.1 - 3.4 6.1 21.2 2 6.9 6.9 2.1 2 0 0 2 2 2 0 Flagellar Assembly Protein A BLOC1S3 PF15753.5 EKX72722.1 - 7.6 6.6 11.9 0.18 11.9 0.6 2.8 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 TRAUB PF08164.12 EKX72723.1 - 2.6e-09 37.5 2.3 2.6e-09 37.5 2.3 1.9 2 0 0 2 2 2 1 Apoptosis-antagonizing transcription factor, C-terminal Nop PF01798.18 EKX72723.1 - 0.0032 17.0 1.3 0.0032 17.0 1.3 1.7 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin AATF-Che1 PF13339.6 EKX72723.1 - 0.012 16.3 11.5 0.067 13.9 11.5 2.3 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor CBP_BcsR PF10945.8 EKX72723.1 - 0.12 11.8 0.5 0.33 10.5 0.5 1.7 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsR Adeno_E1B_19K PF01691.16 EKX72723.1 - 0.44 10.1 2.8 0.66 9.5 0.2 2.2 2 0 0 2 2 2 0 Adenovirus E1B 19K protein / small t-antigen Mlp PF03304.13 EKX72723.1 - 8.5 6.6 11.7 0.13 12.5 1.6 2.9 2 1 1 3 3 3 0 Mlp lipoprotein family FbpA PF05833.11 EKX72724.1 - 2.4e-17 62.9 0.5 3.9e-17 62.2 0.5 1.3 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 EKX72725.1 - 3e-30 105.1 0.0 7.9e-30 103.7 0.0 1.8 1 0 0 1 1 1 1 NFACT protein RNA binding domain NFACT-C PF11923.8 EKX72725.1 - 6.5e-18 64.6 0.0 6.5e-18 64.6 0.0 3.3 3 0 0 3 3 3 1 NFACT protein C-terminal domain Vault_4 PF17796.1 EKX72725.1 - 0.017 15.2 0.0 0.042 13.9 0.0 1.6 1 0 0 1 1 1 0 Major Vault Protein repeat domain AAA_assoc_C PF09821.9 EKX72725.1 - 0.2 12.2 4.2 0.18 12.3 0.3 2.5 2 0 0 2 2 2 0 C-terminal AAA-associated domain Astro_capsid_p PF12226.8 EKX72725.1 - 0.73 8.9 13.3 1.6 7.8 13.3 1.5 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Sporozoite_P67 PF05642.11 EKX72725.1 - 4.9 5.1 16.5 9.5 4.2 16.5 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Rav1p_C PF12234.8 EKX72726.1 - 3.7e-25 88.4 0.3 1.5e-19 69.9 0.2 2.5 2 0 0 2 2 2 2 RAVE protein 1 C terminal Peptidase_M24 PF00557.24 EKX72729.1 - 1e-47 162.6 0.0 3.2e-24 85.8 0.0 2.2 2 0 0 2 2 2 2 Metallopeptidase family M24 MinE PF03776.14 EKX72729.1 - 0.042 13.8 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 Septum formation topological specificity factor MinE FHA PF00498.26 EKX72730.1 - 1.2e-18 67.2 0.1 1.4e-08 35.0 0.1 2.7 2 0 0 2 2 2 2 FHA domain zf-C3HC4_4 PF15227.6 EKX72730.1 - 3.3e-09 36.7 10.7 8.9e-09 35.4 10.7 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EKX72730.1 - 1.3e-08 34.5 5.0 2.6e-08 33.6 5.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EKX72730.1 - 1.9e-08 34.2 6.2 1.1e-07 31.7 6.6 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EKX72730.1 - 2.5e-08 33.6 8.5 5.8e-08 32.5 8.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EKX72730.1 - 1.4e-06 28.1 7.6 3.5e-06 26.8 7.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EKX72730.1 - 4.3e-06 27.0 7.8 4.3e-06 27.0 7.8 2.2 2 0 0 2 2 2 1 Ring finger domain Prok-RING_4 PF14447.6 EKX72730.1 - 5.2e-05 23.0 6.4 0.00022 21.0 6.4 2.0 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EKX72730.1 - 6e-05 22.9 8.5 0.00023 21.0 8.5 2.1 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_10 PF16685.5 EKX72730.1 - 0.0015 18.6 2.8 0.0041 17.2 2.8 1.8 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-RING_4 PF14570.6 EKX72730.1 - 0.027 14.2 5.1 0.029 14.2 2.6 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain VHS PF00790.19 EKX72730.1 - 0.085 12.7 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 VHS domain zf-rbx1 PF12678.7 EKX72730.1 - 0.14 12.4 6.7 0.57 10.5 6.8 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-Nse PF11789.8 EKX72730.1 - 0.15 11.9 2.1 0.37 10.7 2.1 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 EKX72730.1 - 1.7 8.6 7.4 0.41 10.5 3.4 2.0 2 0 0 2 2 2 0 zf-RING of BARD1-type protein FAINT PF04385.15 EKX72731.1 - 0.0019 18.2 0.0 0.0031 17.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 RNA_pol_Rpc4 PF05132.14 EKX72731.1 - 0.062 13.7 0.8 0.43 11.0 0.0 2.0 2 0 0 2 2 2 0 RNA polymerase III RPC4 DUF1542 PF07564.11 EKX72732.1 - 0.14 12.2 0.0 0.22 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) DUF3098 PF11297.8 EKX72732.1 - 0.24 11.0 0.1 0.24 11.0 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3098) OAD_gamma PF04277.13 EKX72733.1 - 0.053 14.1 1.5 1.5 9.5 0.0 3.6 4 0 0 4 4 4 0 Oxaloacetate decarboxylase, gamma chain FAM176 PF14851.6 EKX72733.1 - 0.086 12.5 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 FAM176 family LapA_dom PF06305.11 EKX72733.1 - 1.5 8.7 0.0 1.5 8.7 0.0 3.9 5 0 0 5 5 5 0 Lipopolysaccharide assembly protein A domain PNK3P PF08645.11 EKX72734.1 - 0.013 15.2 0.1 0.027 14.2 0.1 1.7 1 0 0 1 1 1 0 Polynucleotide kinase 3 phosphatase Acid_phosphat_B PF03767.14 EKX72734.1 - 0.13 11.8 0.4 0.25 10.9 0.4 1.5 1 1 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) FAINT PF04385.15 EKX72735.1 - 0.0081 16.2 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72736.1 - 2.8e-31 107.4 38.1 5.2e-05 23.2 2.2 9.4 9 0 0 9 9 9 7 Domain of unknown function, DUF529 Hydrolase_4 PF12146.8 EKX72737.1 - 1.3e-22 80.3 0.0 9.9e-22 77.4 0.0 2.3 2 1 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX72737.1 - 1.3e-11 44.3 12.1 0.0012 18.8 0.2 4.3 3 0 0 3 3 3 3 Domain of unknown function, DUF529 Abhydrolase_6 PF12697.7 EKX72737.1 - 2.3e-05 25.1 0.0 5.1e-05 24.0 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EKX72737.1 - 0.00015 21.5 0.0 0.0012 18.6 0.0 2.4 2 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EKX72737.1 - 0.00037 20.0 0.1 0.048 13.1 0.1 2.4 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 EKX72737.1 - 0.027 14.3 0.0 0.061 13.2 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold MutS_I PF01624.20 EKX72737.1 - 0.2 11.9 1.0 19 5.5 0.0 3.7 5 0 0 5 5 5 0 MutS domain I FAINT PF04385.15 EKX72741.1 - 5.4e-13 48.8 0.2 2.5e-05 24.2 0.1 2.5 2 0 0 2 2 2 2 Domain of unknown function, DUF529 dCMP_cyt_deam_1 PF00383.23 EKX72742.1 - 4.9e-11 42.4 0.4 7.9e-11 41.7 0.4 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EKX72742.1 - 4e-10 39.6 0.1 7.9e-10 38.6 0.1 1.5 1 0 0 1 1 1 1 MafB19-like deaminase TIP120 PF08623.10 EKX72742.1 - 0.031 14.0 0.0 0.05 13.4 0.0 1.3 1 0 0 1 1 1 0 TATA-binding protein interacting (TIP20) FAINT PF04385.15 EKX72744.1 - 2.4e-43 146.1 21.6 1.3e-08 34.8 0.0 6.6 6 0 0 6 6 6 6 Domain of unknown function, DUF529 DUF3519 PF12033.8 EKX72744.1 - 0.00046 20.5 4.1 0.0018 18.7 2.0 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3519) CactinC_cactus PF09732.9 EKX72745.1 - 3.3e-48 162.7 8.0 8.5e-48 161.4 8.0 1.7 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein Cactin_mid PF10312.9 EKX72745.1 - 8.1e-33 113.8 1.5 8.1e-33 113.8 1.5 1.6 2 0 0 2 2 2 1 Conserved mid region of cactin Cytochrom_C_2 PF01322.20 EKX72745.1 - 0.0047 17.8 0.3 0.013 16.4 0.3 1.7 1 0 0 1 1 1 1 Cytochrome C' FAINT PF04385.15 EKX72746.1 - 7.4e-13 48.4 3.0 5.6e-08 32.7 0.3 2.5 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72747.1 - 4.4e-18 65.1 0.0 1.2e-07 31.7 0.0 3.5 3 0 0 3 3 3 3 Domain of unknown function, DUF529 NOG1_N PF17835.1 EKX72749.1 - 0.022 14.7 1.8 0.054 13.5 0.5 2.2 2 0 0 2 2 2 0 NOG1 N-terminal helical domain Sex_peptide PF08138.11 EKX72749.1 - 0.11 12.6 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 Sex peptide (SP) family TarH PF02203.15 EKX72749.1 - 0.2 11.6 4.0 0.27 11.1 0.9 2.2 2 0 0 2 2 2 0 Tar ligand binding domain homologue FUSC PF04632.12 EKX72749.1 - 0.4 9.1 0.3 0.59 8.6 0.3 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family ArAE_2_N PF10337.9 EKX72749.1 - 1.5 7.8 4.5 2.5 7.0 4.5 1.2 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal TPR_2 PF07719.17 EKX72751.1 - 3.7e-11 42.2 7.3 0.0012 18.8 0.1 4.4 5 0 0 5 5 5 3 Tetratricopeptide repeat SHNi-TPR PF10516.9 EKX72751.1 - 2e-09 36.7 0.3 1.1e-08 34.4 0.0 2.3 2 0 0 2 2 2 1 SHNi-TPR TPR_1 PF00515.28 EKX72751.1 - 3.4e-09 36.1 3.8 0.0019 17.9 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EKX72751.1 - 7.4e-08 32.0 7.9 0.23 11.8 0.1 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 EKX72751.1 - 1.4e-06 28.5 0.5 0.013 15.8 0.1 3.1 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EKX72751.1 - 5.3e-05 22.8 0.1 0.0057 16.3 0.0 3.3 3 0 0 3 3 3 1 TPR repeat TPR_14 PF13428.6 EKX72751.1 - 0.00048 20.7 0.0 5.2 8.2 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TruD PF01142.18 EKX72751.1 - 0.0019 17.1 0.7 0.0027 16.6 0.7 1.3 1 1 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) TPR_16 PF13432.6 EKX72751.1 - 0.0027 18.3 0.0 1.7 9.3 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EKX72751.1 - 0.0036 17.5 2.5 1.1 9.5 0.2 3.2 2 1 2 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 Syntaxin-6_N PF09177.11 EKX72751.1 - 0.007 16.9 1.0 0.018 15.6 1.0 1.7 1 0 0 1 1 1 1 Syntaxin 6, N-terminal TPR_7 PF13176.6 EKX72751.1 - 0.02 14.9 0.5 3.1 8.0 0.0 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 EKX72751.1 - 0.023 14.7 6.8 0.98 9.5 0.4 3.8 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain SPO22 PF08631.10 EKX72751.1 - 0.083 12.4 2.1 3.8 6.9 0.0 2.3 2 0 0 2 2 2 0 Meiosis protein SPO22/ZIP4 like DUF892 PF05974.12 EKX72751.1 - 0.11 12.6 2.4 0.086 12.9 0.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF892) TPR_6 PF13174.6 EKX72751.1 - 0.22 12.2 2.2 89 4.1 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 EKX72751.1 - 0.24 11.3 0.7 15 5.6 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Prefoldin PF02996.17 EKX72751.1 - 1 9.3 9.9 4.5 7.2 0.8 3.4 2 1 1 3 3 3 0 Prefoldin subunit zf-C4H2 PF10146.9 EKX72751.1 - 5 7.4 7.5 3.4 7.9 4.3 2.0 1 1 1 2 2 2 0 Zinc finger-containing protein Myb_DNA-bind_7 PF15963.5 EKX72752.1 - 4e-19 68.3 0.3 4e-19 68.3 0.3 2.1 2 0 0 2 2 2 1 Myb DNA-binding like AT_hook PF02178.19 EKX72752.1 - 0.045 13.6 0.6 0.18 11.8 0.6 2.1 1 0 0 1 1 1 0 AT hook motif MreB_Mbl PF06723.13 EKX72752.1 - 0.2 10.5 0.0 0.4 9.5 0.0 1.4 1 0 0 1 1 1 0 MreB/Mbl protein DUF726 PF05277.12 EKX72753.1 - 8.3e-81 271.6 4.2 5.9e-80 268.8 4.2 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF726) DUF676 PF05057.14 EKX72753.1 - 0.00032 20.3 0.1 0.0017 17.9 0.0 2.0 2 0 0 2 2 2 1 Putative serine esterase (DUF676) Abhydrolase_1 PF00561.20 EKX72753.1 - 0.00049 19.8 0.0 0.0012 18.6 0.0 1.7 1 0 0 1 1 1 1 alpha/beta hydrolase fold Cutinase PF01083.22 EKX72753.1 - 0.0017 18.3 0.0 0.0032 17.5 0.0 1.4 1 0 0 1 1 1 1 Cutinase VirJ PF06057.11 EKX72753.1 - 0.012 15.4 0.0 0.024 14.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Phage_HK97_TLTM PF06120.11 EKX72753.1 - 0.05 12.8 0.2 0.095 11.9 0.2 1.3 1 0 0 1 1 1 0 Tail length tape measure protein DDR PF08841.10 EKX72753.1 - 0.16 10.9 1.3 0.31 10.0 1.3 1.4 1 0 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain UQ_con PF00179.26 EKX72755.1 - 2.1e-54 183.0 0.1 2.3e-54 182.8 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EKX72755.1 - 0.00011 21.9 0.0 0.00015 21.5 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EKX72755.1 - 0.016 15.5 0.1 0.016 15.5 0.1 1.3 1 0 0 1 1 1 0 RWD domain UEV PF05743.13 EKX72755.1 - 0.021 14.7 0.1 0.033 14.0 0.1 1.4 1 0 0 1 1 1 0 UEV domain NAP PF00956.18 EKX72756.1 - 1.6e-64 217.7 11.3 8.4e-63 212.1 11.3 2.0 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) Mst1_SARAH PF11629.8 EKX72756.1 - 0.0016 18.4 6.9 0.31 11.1 1.2 3.5 3 0 0 3 3 3 2 C terminal SARAH domain of Mst1 FCH PF00611.23 EKX72756.1 - 0.0021 18.3 0.4 0.0061 16.8 0.1 2.0 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain Muted PF14942.6 EKX72756.1 - 0.12 12.7 0.3 0.12 12.7 0.3 2.7 2 1 0 2 2 2 0 Organelle biogenesis, Muted-like protein Proteasome PF00227.26 EKX72757.1 - 6.9e-34 117.0 0.2 8.1e-34 116.8 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit FAINT PF04385.15 EKX72759.1 - 0.0049 16.9 4.1 0.049 13.7 0.1 3.2 3 1 0 3 3 3 1 Domain of unknown function, DUF529 SH3_5 PF08460.10 EKX72759.1 - 0.0049 16.9 0.1 0.082 13.0 0.0 2.5 2 0 0 2 2 2 1 Bacterial SH3 domain PCNA_N PF00705.18 EKX72760.1 - 4.5e-43 146.0 1.7 8.4e-43 145.1 1.7 1.4 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 EKX72760.1 - 1.7e-27 96.1 0.0 3.1e-27 95.3 0.0 1.4 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, C-terminal domain EMC3_TMCO1 PF01956.16 EKX72761.1 - 3.3e-20 72.5 0.1 4.2e-20 72.2 0.1 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Hydrolase_3 PF08282.12 EKX72762.1 - 1.1e-39 136.7 0.0 1.5e-39 136.3 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EKX72762.1 - 0.00032 20.3 0.0 0.62 9.5 0.0 2.2 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Fer4_19 PF06902.11 EKX72762.1 - 0.014 15.4 0.6 6.1 7.0 0.1 2.5 2 0 0 2 2 2 0 Divergent 4Fe-4S mono-cluster FAINT PF04385.15 EKX72763.1 - 2.9e-07 30.4 6.0 0.0061 16.6 0.3 2.8 3 0 0 3 3 3 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72764.1 - 1.4e-15 57.1 5.6 3.9e-08 33.2 0.3 4.7 4 0 0 4 4 4 3 Domain of unknown function, DUF529 Hydrolase_3 PF08282.12 EKX72765.1 - 1.1e-33 117.0 0.0 1.4e-33 116.8 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EKX72765.1 - 0.016 14.7 0.0 0.8 9.2 0.0 2.1 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase DUF1664 PF07889.12 EKX72767.1 - 0.029 14.4 1.1 0.075 13.1 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) TIP49 PF06068.13 EKX72768.1 - 1.2e-151 504.9 0.0 1.5e-151 504.6 0.0 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EKX72768.1 - 5.2e-20 71.4 0.3 1.5e-19 69.9 0.3 1.9 1 0 0 1 1 1 1 TIP49 AAA-lid domain Mg_chelatase PF01078.21 EKX72768.1 - 6.9e-08 32.1 0.3 2.1e-05 24.0 0.2 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA PF00004.29 EKX72768.1 - 8.1e-08 32.8 0.2 9.5e-05 22.8 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EKX72768.1 - 7e-07 29.1 0.1 0.0067 16.2 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EKX72768.1 - 7.5e-07 29.5 0.0 0.0057 16.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain DnaB_C PF03796.15 EKX72768.1 - 5.1e-05 22.7 0.1 0.00011 21.6 0.0 1.6 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain Zeta_toxin PF06414.12 EKX72768.1 - 0.00011 21.5 0.0 0.00024 20.4 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 EKX72768.1 - 0.00011 22.6 0.1 0.00069 20.0 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain Sigma54_activat PF00158.26 EKX72768.1 - 0.00044 20.0 0.0 0.68 9.6 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_5 PF07728.14 EKX72768.1 - 0.00053 20.0 0.1 0.085 12.8 0.0 2.9 2 1 1 3 3 3 1 AAA domain (dynein-related subfamily) CPT PF07931.12 EKX72768.1 - 0.00069 19.5 0.0 0.01 15.7 0.0 2.2 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein AAA_19 PF13245.6 EKX72768.1 - 0.00077 19.8 1.2 0.023 15.1 1.2 2.8 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EKX72768.1 - 0.002 18.6 1.0 0.0066 16.9 0.1 2.3 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.6 EKX72768.1 - 0.007 16.0 0.0 0.034 13.7 0.1 1.9 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 EKX72768.1 - 0.0085 15.4 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_18 PF13238.6 EKX72768.1 - 0.012 16.2 0.0 0.087 13.4 0.1 2.6 2 1 0 2 2 1 0 AAA domain AAA_29 PF13555.6 EKX72768.1 - 0.014 15.1 0.2 0.12 12.2 0.1 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain ATPase PF06745.13 EKX72768.1 - 0.063 12.6 0.2 0.15 11.4 0.2 1.5 1 0 0 1 1 1 0 KaiC NACHT PF05729.12 EKX72768.1 - 0.098 12.6 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain ResIII PF04851.15 EKX72768.1 - 0.1 12.6 0.1 4.4 7.3 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EKX72768.1 - 0.1 12.3 0.1 5.5 6.7 0.1 2.3 2 0 0 2 2 2 0 AAA domain Tantalus PF15386.6 EKX72770.1 - 0.099 12.7 0.2 0.19 11.9 0.2 1.3 1 0 0 1 1 1 0 Drosophila Tantalus-like CHCH PF06747.13 EKX72771.1 - 0.0082 16.3 1.4 0.013 15.6 1.4 1.3 1 0 0 1 1 1 1 CHCH domain Colipase-like PF15083.6 EKX72771.1 - 0.022 14.8 1.0 0.028 14.5 1.0 1.1 1 0 0 1 1 1 0 Colipase-like DUF382 PF04037.13 EKX72774.1 - 2.1e-55 186.3 2.0 2.1e-55 186.3 2.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF382) PSP PF04046.16 EKX72774.1 - 2.6e-21 75.2 3.4 5.2e-21 74.3 2.3 2.1 2 0 0 2 2 2 1 PSP UPF0172 PF03665.13 EKX72774.1 - 0.021 14.9 0.3 0.048 13.7 0.3 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) GCR1_C PF12550.8 EKX72775.1 - 0.058 13.7 0.0 0.18 12.1 0.0 1.9 1 0 0 1 1 1 0 Transcriptional activator of glycolytic enzymes GHL6 PF14871.6 EKX72775.1 - 0.17 12.1 0.0 2.2 8.5 0.0 2.3 2 0 0 2 2 2 0 Hypothetical glycosyl hydrolase 6 Choline_kinase PF01633.20 EKX72776.1 - 2.9e-28 98.9 0.1 4e-28 98.5 0.1 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EKX72776.1 - 4.2e-05 23.6 0.0 7.1e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EKX72776.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Ecdysteroid kinase Hydrolase_4 PF12146.8 EKX72777.1 - 1.7e-23 83.2 0.0 1.8e-22 79.8 0.0 2.5 2 1 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX72777.1 - 3.1e-16 59.2 0.4 2.3e-05 24.4 0.0 4.0 3 0 0 3 3 3 3 Domain of unknown function, DUF529 Abhydrolase_6 PF12697.7 EKX72777.1 - 0.0015 19.2 0.0 0.0038 17.9 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EKX72777.1 - 0.0036 17.0 0.0 0.052 13.2 0.0 2.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF900 PF05990.12 EKX72777.1 - 0.037 13.5 0.2 0.19 11.2 0.0 2.2 3 0 0 3 3 3 0 Alpha/beta hydrolase of unknown function (DUF900) LIDHydrolase PF10230.9 EKX72777.1 - 0.043 13.4 0.0 0.081 12.5 0.0 1.4 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase PGAP1 PF07819.13 EKX72777.1 - 0.052 13.3 0.0 0.082 12.6 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_3 PF07859.13 EKX72777.1 - 0.071 13.0 0.0 0.24 11.2 0.0 1.8 2 0 0 2 2 2 0 alpha/beta hydrolase fold FAINT PF04385.15 EKX72780.1 - 1.1e-08 35.0 0.2 2.8e-06 27.3 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 RHH_7 PF16777.5 EKX72780.1 - 0.5 10.8 2.0 1.2 9.6 0.1 2.3 2 0 0 2 2 2 0 Transcriptional regulator, RHH-like, CopG FAINT PF04385.15 EKX72781.1 - 1.8e-08 34.4 4.0 0.00056 19.9 0.0 3.9 3 0 0 3 3 3 3 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72782.1 - 0.00023 21.2 0.0 0.00041 20.4 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function, DUF529 DUF687 PF05095.12 EKX72783.1 - 0.042 12.4 0.0 0.087 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF687) Peptidase_C9 PF01707.16 EKX72783.1 - 0.11 12.0 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Peptidase family C9 Lactococcin PF04369.13 EKX72783.1 - 0.11 12.6 0.1 0.34 11.1 0.1 1.8 1 0 0 1 1 1 0 Lactococcin-like family FAINT PF04385.15 EKX72784.1 - 1.8e-07 31.1 0.0 0.003 17.6 0.0 2.5 2 1 0 2 2 2 2 Domain of unknown function, DUF529 DUF3455 PF11937.8 EKX72785.1 - 0.0042 17.5 1.1 0.0064 16.9 1.1 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3455) FAINT PF04385.15 EKX72785.1 - 0.0098 15.9 0.3 0.017 15.2 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 DUF2300 PF10062.9 EKX72785.1 - 2.3 8.3 5.6 0.38 10.8 0.3 2.2 3 0 0 3 3 3 0 Predicted secreted protein (DUF2300) FAINT PF04385.15 EKX72787.1 - 3e-06 27.2 0.1 5.9e-06 26.3 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function, DUF529 YkuD_2 PF13645.6 EKX72787.1 - 0.00089 18.7 0.3 0.0037 16.7 0.0 2.0 2 0 0 2 2 2 1 L,D-transpeptidase catalytic domain GATA PF00320.27 EKX72787.1 - 0.11 12.2 0.2 0.24 11.0 0.2 1.6 1 0 0 1 1 1 0 GATA zinc finger TPR_1 PF00515.28 EKX72788.1 - 7e-18 63.6 0.8 3.4e-06 26.6 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EKX72788.1 - 3.4e-14 51.7 0.7 3.2e-05 23.7 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EKX72788.1 - 5.8e-09 35.5 1.5 0.0011 18.6 0.0 3.2 3 0 0 3 3 3 2 TPR repeat TPR_8 PF13181.6 EKX72788.1 - 5.9e-09 35.4 1.3 0.0032 17.6 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EKX72788.1 - 6.4e-08 32.8 0.8 1.9e-06 28.1 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EKX72788.1 - 1.6e-05 24.6 2.9 0.00019 21.3 0.1 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat MIT PF04212.18 EKX72788.1 - 0.001 19.1 3.1 0.34 11.0 0.1 2.7 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain TPR_16 PF13432.6 EKX72788.1 - 0.0011 19.5 0.4 0.11 13.2 0.0 2.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 EKX72788.1 - 0.027 14.6 0.1 1.5 9.1 0.1 2.7 1 1 2 3 3 3 0 Tetratricopeptide repeat SPO22 PF08631.10 EKX72788.1 - 0.033 13.7 0.7 0.086 12.3 0.1 1.8 2 0 0 2 2 2 0 Meiosis protein SPO22/ZIP4 like HTH_Bact PF18768.1 EKX72788.1 - 0.057 13.0 0.3 0.74 9.4 0.1 2.3 2 0 0 2 2 2 0 Helix-turn-helix bacterial domain ANAPC3 PF12895.7 EKX72788.1 - 0.091 13.0 2.3 0.18 12.0 0.7 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 SHNi-TPR PF10516.9 EKX72788.1 - 0.1 12.1 0.0 14 5.3 0.0 2.7 2 0 0 2 2 2 0 SHNi-TPR TPR_14 PF13428.6 EKX72788.1 - 0.11 13.4 0.2 15 6.7 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Helicase_C PF00271.31 EKX72790.1 - 4.5e-19 68.8 0.0 8.8e-19 67.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EKX72790.1 - 4.6e-08 33.0 0.0 9.7e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA PF00004.29 EKX72791.1 - 5.7e-16 59.1 0.4 1.5e-15 57.8 0.1 1.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EKX72791.1 - 1.3e-15 57.5 0.1 4.2e-15 55.9 0.1 1.9 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EKX72791.1 - 2.3e-14 53.5 0.5 9.1e-12 45.1 1.0 2.2 1 1 1 2 2 2 1 DNA polymerase III, delta subunit AAA_14 PF13173.6 EKX72791.1 - 5.7e-07 29.6 0.0 1.5e-06 28.3 0.0 1.7 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EKX72791.1 - 2e-06 28.3 0.1 0.00084 19.8 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EKX72791.1 - 3.8e-06 26.8 0.4 5.8e-05 22.9 0.1 2.7 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EKX72791.1 - 4.1e-06 27.1 0.3 0.0036 17.6 0.0 2.4 1 1 1 2 2 2 2 AAA domain Rad17 PF03215.15 EKX72791.1 - 7.1e-06 26.1 0.0 3.3e-05 23.9 0.0 2.1 1 1 1 2 2 2 1 Rad17 P-loop domain AAA_5 PF07728.14 EKX72791.1 - 5.9e-05 23.1 0.2 0.00029 20.9 0.2 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EKX72791.1 - 7.4e-05 22.6 0.0 0.0002 21.1 0.0 1.7 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EKX72791.1 - 0.00013 21.4 0.0 0.0025 17.2 0.0 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 EKX72791.1 - 0.00024 20.6 0.0 0.00039 20.0 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_19 PF13245.6 EKX72791.1 - 0.00036 20.9 0.2 0.0089 16.4 0.0 2.1 1 1 1 2 2 2 1 AAA domain AAA_11 PF13086.6 EKX72791.1 - 0.00037 20.4 0.0 0.0005 20.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 EKX72791.1 - 0.00041 20.2 0.3 0.0026 17.6 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.13 EKX72791.1 - 0.00045 20.0 0.8 0.00072 19.4 0.8 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit TniB PF05621.11 EKX72791.1 - 0.00049 19.6 0.1 0.086 12.2 0.0 2.3 2 0 0 2 2 2 1 Bacterial TniB protein MCM PF00493.23 EKX72791.1 - 0.0006 19.0 0.0 0.00095 18.3 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain AAA_18 PF13238.6 EKX72791.1 - 0.00068 20.2 0.0 0.0022 18.6 0.0 1.8 1 1 1 2 2 2 1 AAA domain NTPase_1 PF03266.15 EKX72791.1 - 0.0011 18.9 1.5 0.9 9.4 0.1 2.3 1 1 1 2 2 2 2 NTPase AAA_25 PF13481.6 EKX72791.1 - 0.0018 17.9 0.3 0.0093 15.6 0.1 2.0 1 1 1 2 2 2 1 AAA domain AAA_30 PF13604.6 EKX72791.1 - 0.0025 17.5 0.0 0.0048 16.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EKX72791.1 - 0.003 17.3 0.0 0.0054 16.5 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase IstB_IS21 PF01695.17 EKX72791.1 - 0.0036 17.0 0.0 0.009 15.8 0.0 1.7 1 1 0 1 1 1 1 IstB-like ATP binding protein Sigma54_activ_2 PF14532.6 EKX72791.1 - 0.0087 16.2 0.1 0.042 14.0 0.1 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_assoc_2 PF16193.5 EKX72791.1 - 0.013 15.9 0.1 0.036 14.4 0.0 1.9 2 0 0 2 2 1 0 AAA C-terminal domain RNA_helicase PF00910.22 EKX72791.1 - 0.014 15.8 0.1 0.084 13.3 0.1 2.2 1 1 0 1 1 1 0 RNA helicase KTI12 PF08433.10 EKX72791.1 - 0.015 14.8 0.0 0.029 13.8 0.0 1.5 1 1 0 1 1 1 0 Chromatin associated protein KTI12 DEAD PF00270.29 EKX72791.1 - 0.019 14.7 0.4 1.5 8.5 0.1 2.5 1 1 1 2 2 2 0 DEAD/DEAH box helicase DUF815 PF05673.13 EKX72791.1 - 0.025 13.7 0.0 0.046 12.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) TIP49 PF06068.13 EKX72791.1 - 0.031 13.5 0.0 0.044 13.0 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain FtsK_SpoIIIE PF01580.18 EKX72791.1 - 0.049 13.0 0.0 0.11 11.8 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_33 PF13671.6 EKX72791.1 - 0.061 13.5 0.2 0.11 12.6 0.2 1.6 1 1 0 1 1 1 0 AAA domain DUF2247 PF10004.9 EKX72791.1 - 0.089 12.6 0.0 0.27 11.0 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2247) AAA_28 PF13521.6 EKX72791.1 - 0.16 12.2 0.0 0.28 11.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 EKX72791.1 - 1.6 8.0 4.7 13 5.0 0.1 3.2 2 1 1 3 3 3 0 KaiC Mito_carr PF00153.27 EKX72792.1 - 3.3e-48 161.5 3.3 1.7e-19 69.5 0.2 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein RBFA PF02033.18 EKX72793.1 - 6.2e-13 49.1 1.6 1.1e-12 48.4 0.0 2.2 3 0 0 3 3 3 1 Ribosome-binding factor A Myb_DNA-bind_7 PF15963.5 EKX72793.1 - 0.09 12.7 1.3 0.29 11.1 1.3 1.9 1 0 0 1 1 1 0 Myb DNA-binding like FAINT PF04385.15 EKX72794.1 - 2.8e-07 30.5 3.0 3.7e-05 23.7 0.9 2.8 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72795.1 - 1.1e-10 41.4 1.2 0.0002 21.3 0.1 2.7 2 1 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72796.1 - 1.3e-15 57.2 0.0 9e-05 22.5 0.0 3.5 3 0 0 3 3 3 3 Domain of unknown function, DUF529 TypeIII_RM_meth PF12564.8 EKX72796.1 - 0.11 12.6 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 Type III restriction/modification enzyme methylation subunit FAINT PF04385.15 EKX72797.1 - 3.9e-07 30.0 0.8 6.4e-07 29.3 0.4 1.6 2 0 0 2 2 2 1 Domain of unknown function, DUF529 PGDH_C PF16896.5 EKX72797.1 - 0.12 12.3 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Phosphogluconate dehydrogenase (decarboxylating) C-term FAINT PF04385.15 EKX72800.1 - 0.0019 18.2 2.6 0.027 14.5 0.4 2.5 2 0 0 2 2 2 1 Domain of unknown function, DUF529 SspH PF08141.12 EKX72800.1 - 0.13 12.4 0.2 0.31 11.2 0.2 1.7 1 0 0 1 1 1 0 Small acid-soluble spore protein H family FAINT PF04385.15 EKX72801.1 - 3.7e-07 30.1 0.1 8.7e-07 28.9 0.0 1.6 1 1 1 2 2 2 1 Domain of unknown function, DUF529 S4 PF01479.25 EKX72802.1 - 5e-09 35.7 0.0 8.9e-09 34.9 0.0 1.4 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 EKX72802.1 - 9.4e-09 36.1 0.9 1.4e-08 35.5 0.9 1.4 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain GTP_EFTU_D2 PF03144.25 EKX72802.1 - 0.047 14.1 0.0 3.1 8.3 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu domain 2 Ribosomal_S28e PF01200.18 EKX72803.1 - 4.5e-32 109.8 0.9 4.9e-32 109.7 0.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e FAINT PF04385.15 EKX72804.1 - 0.047 13.8 2.1 0.052 13.6 0.0 2.1 2 1 0 2 2 2 0 Domain of unknown function, DUF529 Mitofilin PF09731.9 EKX72805.1 - 0.57 9.0 5.2 0.75 8.6 5.2 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Ndc1_Nup PF09531.10 EKX72805.1 - 0.73 8.4 4.9 0.94 8.1 4.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MORN PF02493.20 EKX72806.1 - 7.3e-29 97.9 45.7 1.5e-05 24.6 1.3 8.7 8 0 0 8 8 8 8 MORN repeat ParA PF10609.9 EKX72807.1 - 5.2e-71 239.0 0.0 7e-71 238.5 0.0 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EKX72807.1 - 8.5e-13 48.5 0.0 1.3e-12 47.9 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EKX72807.1 - 1.9e-09 37.7 0.1 1.2e-08 35.1 0.1 2.1 1 1 0 1 1 1 1 AAA domain MipZ PF09140.11 EKX72807.1 - 1.2e-07 31.4 0.0 3.9e-07 29.6 0.0 1.8 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 EKX72807.1 - 1.8e-07 30.7 0.5 2.9e-05 23.4 0.0 2.4 2 1 1 3 3 3 1 Anion-transporting ATPase AAA_26 PF13500.6 EKX72807.1 - 3.2e-05 23.9 0.1 0.095 12.5 0.0 2.1 2 0 0 2 2 2 2 AAA domain CBP_BcsQ PF06564.12 EKX72807.1 - 0.00011 21.8 0.1 0.0021 17.6 0.1 2.1 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ MeaB PF03308.16 EKX72807.1 - 0.00063 18.8 0.1 0.00093 18.2 0.1 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NB-ARC PF00931.22 EKX72807.1 - 0.0067 15.6 0.2 0.014 14.6 0.2 1.5 1 0 0 1 1 1 1 NB-ARC domain Fer4_NifH PF00142.18 EKX72807.1 - 0.017 14.6 0.2 0.053 12.9 0.0 1.8 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family APS_kinase PF01583.20 EKX72807.1 - 0.021 14.7 0.1 0.037 13.9 0.1 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase SRP54 PF00448.22 EKX72807.1 - 0.038 13.6 0.1 0.077 12.6 0.1 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_16 PF13191.6 EKX72807.1 - 0.07 13.5 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain CLP1_P PF16575.5 EKX72807.1 - 0.12 12.2 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_30 PF13604.6 EKX72807.1 - 0.13 11.9 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EKX72807.1 - 0.14 12.0 0.2 0.29 11.0 0.2 1.5 1 0 0 1 1 1 0 RsgA GTPase NTPase_1 PF03266.15 EKX72807.1 - 0.15 12.0 0.7 0.23 11.3 0.1 1.6 2 0 0 2 2 2 0 NTPase AAA_5 PF07728.14 EKX72807.1 - 0.16 11.9 0.0 0.34 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DNA_primase_lrg PF04104.14 EKX72808.1 - 2.4e-69 233.7 0.1 5.7e-69 232.5 0.0 1.7 2 0 0 2 2 2 1 Eukaryotic and archaeal DNA primase, large subunit SPRY PF00622.28 EKX72809.1 - 3.6e-11 43.2 0.8 2.6e-08 34.0 0.3 2.7 2 1 0 2 2 2 2 SPRY domain Ntox25 PF15530.6 EKX72809.1 - 0.093 12.9 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial toxin 25 Prenyltransf PF01255.19 EKX72810.1 - 4.9e-48 163.6 0.0 1e-47 162.5 0.0 1.5 1 1 0 1 1 1 1 Putative undecaprenyl diphosphate synthase SAD_SRA PF02182.17 EKX72811.1 - 3e-12 46.5 0.0 5.8e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 SAD/SRA domain SET PF00856.28 EKX72813.1 - 3.9e-17 63.1 0.2 3.8e-16 59.9 0.2 2.2 1 1 0 1 1 1 1 SET domain Pre-SET PF05033.16 EKX72813.1 - 1e-10 42.2 2.9 1e-10 42.2 2.9 2.1 3 0 0 3 3 3 1 Pre-SET motif Thioredoxin PF00085.20 EKX72814.1 - 7.2e-42 141.6 0.3 1e-26 92.9 0.1 3.6 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.6 EKX72814.1 - 3.9e-24 85.6 5.2 1.1e-13 51.5 1.5 3.5 2 1 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.6 EKX72814.1 - 8.7e-09 35.8 0.8 0.00026 21.4 0.0 4.1 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EKX72814.1 - 1.9e-07 31.3 0.2 0.039 14.3 0.0 4.0 3 2 1 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.21 EKX72814.1 - 2.4e-07 30.7 0.3 0.0011 18.9 0.0 3.5 3 1 1 4 4 4 2 AhpC/TSA family Thioredoxin_7 PF13899.6 EKX72814.1 - 6.4e-07 29.5 0.9 0.0017 18.5 0.0 2.9 3 0 0 3 3 3 2 Thioredoxin-like OST3_OST6 PF04756.13 EKX72814.1 - 3.4e-06 26.6 3.7 0.00031 20.2 0.0 3.2 2 1 1 3 3 3 1 OST3 / OST6 family, transporter family ERp29_N PF07912.13 EKX72814.1 - 7.5e-05 22.9 0.1 0.43 10.7 0.0 2.8 2 0 0 2 2 2 2 ERp29, N-terminal domain Redoxin PF08534.10 EKX72814.1 - 0.00017 21.3 0.1 0.015 15.0 0.0 2.4 2 0 0 2 2 2 1 Redoxin Thioredoxin_9 PF14595.6 EKX72814.1 - 0.011 15.5 0.0 0.37 10.6 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin TraF PF13728.6 EKX72814.1 - 0.028 14.2 0.0 1.2 8.9 0.0 2.4 2 0 0 2 2 2 0 F plasmid transfer operon protein BatD PF13584.6 EKX72815.1 - 0.029 13.2 0.0 0.26 10.0 0.0 2.0 2 0 0 2 2 2 0 Oxygen tolerance DUF4271 PF14093.6 EKX72815.1 - 0.19 11.6 2.4 0.27 11.1 2.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4271) 2OG-FeII_Oxy_3 PF13640.6 EKX72816.1 - 3.8e-11 43.7 0.0 8.5e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.13 EKX72816.1 - 0.025 13.7 0.0 0.03 13.4 0.0 1.3 1 0 0 1 1 1 0 Poxvirus C4/C10 protein zf-P11 PF03854.14 EKX72817.1 - 0.035 13.8 1.0 0.068 12.8 1.0 1.4 1 0 0 1 1 1 0 P-11 zinc finger FAINT PF04385.15 EKX72818.1 - 8.5e-07 28.9 0.0 0.0064 16.5 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Acetyltransf_2 PF00797.17 EKX72819.1 - 1.3e-73 247.8 0.9 1.6e-73 247.4 0.9 1.0 1 0 0 1 1 1 1 N-acetyltransferase FAINT PF04385.15 EKX72820.1 - 8.7e-36 121.8 19.3 2.3e-07 30.8 0.1 5.7 6 0 0 6 6 6 5 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72821.1 - 4.8e-06 26.5 0.7 0.069 13.2 0.1 2.9 3 0 0 3 3 3 2 Domain of unknown function, DUF529 CooC_C PF15976.5 EKX72821.1 - 0.081 13.0 0.0 0.22 11.6 0.0 1.7 1 0 0 1 1 1 0 CS1-pili formation C-terminal LSM PF01423.22 EKX72824.1 - 6.4e-16 57.8 0.2 7.6e-16 57.6 0.2 1.1 1 0 0 1 1 1 1 LSM domain tRNA-synt_1 PF00133.22 EKX72826.1 - 2.6e-40 138.3 7.0 1.4e-25 89.6 0.4 4.6 3 2 1 4 4 4 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EKX72826.1 - 7.7e-24 84.2 2.5 4.5e-16 58.6 0.0 3.7 4 1 1 5 5 5 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EKX72826.1 - 4.8e-11 42.8 0.1 1.3e-10 41.4 0.1 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1_2 PF13603.6 EKX72826.1 - 3.7e-06 26.6 0.0 6.5e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EKX72826.1 - 0.00043 19.7 0.0 0.068 12.5 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain ubiquitin PF00240.23 EKX72828.1 - 1.7e-20 72.5 0.0 3.1e-20 71.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EKX72828.1 - 2e-07 30.8 0.0 4.1e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EKX72828.1 - 2.5e-05 24.7 0.0 0.00012 22.5 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EKX72828.1 - 0.049 13.7 0.0 0.16 12.1 0.0 1.8 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Methyltransf_11 PF08241.12 EKX72829.1 - 5.9e-16 58.9 0.0 9e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EKX72829.1 - 3e-14 52.9 0.0 1.8e-13 50.4 0.0 1.9 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EKX72829.1 - 1.3e-13 51.5 0.0 2e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EKX72829.1 - 2.4e-09 37.2 0.0 3.4e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EKX72829.1 - 5.2e-09 36.1 0.0 7.3e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EKX72829.1 - 7.1e-06 26.7 0.0 1.3e-05 25.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EKX72829.1 - 0.0081 16.0 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase Gate PF07670.14 EKX72829.1 - 0.036 14.3 0.0 0.056 13.7 0.0 1.4 1 0 0 1 1 1 0 Nucleoside recognition FAINT PF04385.15 EKX72830.1 - 2.5e-51 171.7 57.4 2.1e-05 24.5 2.8 15.5 15 0 0 15 15 15 13 Domain of unknown function, DUF529 Viral_P18 PF04521.13 EKX72830.1 - 0.0058 16.4 0.0 0.016 15.0 0.0 1.7 1 0 0 1 1 1 1 ssRNA positive strand viral 18kD cysteine rich protein RVT_1 PF00078.27 EKX72831.1 - 4.3e-35 121.2 0.1 7.5e-35 120.5 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Seryl_tRNA_N PF02403.22 EKX72832.1 - 0.00047 20.3 5.3 0.00047 20.3 5.3 3.7 5 1 1 6 6 6 1 Seryl-tRNA synthetase N-terminal domain DUF948 PF06103.11 EKX72832.1 - 0.097 12.9 13.3 3.4 8.0 0.2 5.3 3 2 2 5 5 5 0 Bacterial protein of unknown function (DUF948) Tim17 PF02466.19 EKX72835.1 - 2.3e-17 63.4 3.1 3e-17 63.0 3.1 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Aph-1 PF06105.12 EKX72835.1 - 0.026 13.9 0.1 0.037 13.4 0.1 1.2 1 0 0 1 1 1 0 Aph-1 protein ERO1 PF04137.15 EKX72836.1 - 2.7e-18 66.3 0.0 3.2e-18 66.0 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) Ribosomal_60s PF00428.19 EKX72837.1 - 6.3 7.5 10.2 0.1 13.2 1.2 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein ERO1 PF04137.15 EKX72838.1 - 7e-40 137.3 2.6 7.9e-40 137.1 2.6 1.0 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) SKG6 PF08693.10 EKX72838.1 - 0.23 10.9 1.2 0.5 9.8 1.2 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Beach PF02138.18 EKX72839.1 - 2.4e-90 302.7 0.0 3.4e-90 302.2 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain 60KD_IMP PF02096.20 EKX72840.1 - 1.4e-13 51.1 0.7 1.7e-13 50.8 0.7 1.1 1 0 0 1 1 1 1 60Kd inner membrane protein Band_7 PF01145.25 EKX72841.1 - 3.2e-26 92.4 0.1 5.1e-26 91.8 0.1 1.3 1 1 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 EKX72841.1 - 0.098 12.4 0.1 0.18 11.5 0.1 1.4 1 0 0 1 1 1 0 SPFH domain-Band 7 family Adeno_E3_CR1 PF02440.15 EKX72842.1 - 0.08 12.7 0.7 1 9.2 0.0 2.4 2 0 0 2 2 2 0 Adenovirus E3 region protein CR1 BT1 PF03092.16 EKX72843.1 - 1.5e-55 188.4 23.4 1.7e-40 138.8 11.1 2.0 1 1 1 2 2 2 2 BT1 family CBM_11 PF03425.13 EKX72844.1 - 0.53 10.1 3.8 0.23 11.3 0.9 1.9 2 1 0 2 2 2 0 Carbohydrate binding domain (family 11) PHD PF00628.29 EKX72847.1 - 0.071 13.0 2.0 0.15 12.0 2.0 1.5 1 0 0 1 1 1 0 PHD-finger Glutaredoxin PF00462.24 EKX72847.1 - 0.11 12.7 1.8 0.29 11.4 0.0 2.4 2 1 0 2 2 2 0 Glutaredoxin PPR_2 PF13041.6 EKX72848.1 - 2.8e-62 206.7 22.9 1.8e-15 56.9 0.2 8.9 3 1 6 9 9 9 8 PPR repeat family PPR PF01535.20 EKX72848.1 - 1.7e-50 165.8 27.7 1.9e-07 30.9 0.4 11.2 11 0 0 11 11 11 8 PPR repeat PPR_1 PF12854.7 EKX72848.1 - 3.2e-49 164.3 12.6 2.5e-08 33.5 0.1 8.9 9 0 0 9 9 9 7 PPR repeat PPR_3 PF13812.6 EKX72848.1 - 1.4e-43 146.8 20.5 8.7e-11 41.7 0.8 7.4 5 1 4 9 9 9 7 Pentatricopeptide repeat domain PPR_long PF17177.4 EKX72848.1 - 4e-23 81.9 0.0 7.7e-12 45.0 0.0 3.9 2 1 2 4 4 4 3 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 EKX72848.1 - 2.1e-06 27.6 0.6 0.5 10.2 0.0 5.1 4 1 1 5 5 5 2 Mitochondrial ATPase expression TPR_19 PF14559.6 EKX72848.1 - 0.0021 18.5 0.0 0.39 11.2 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EKX72848.1 - 0.005 17.6 0.0 46 5.2 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF3212 PF11486.8 EKX72848.1 - 0.22 11.6 2.0 1.2 9.1 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3212) ECSIT PF06239.11 EKX72848.1 - 0.52 9.4 1.7 13 4.8 0.0 3.4 4 0 0 4 4 4 0 Evolutionarily conserved signalling intermediate in Toll pathway Brix PF04427.18 EKX72852.1 - 1.1e-24 87.7 0.1 1.6e-24 87.1 0.1 1.3 1 0 0 1 1 1 1 Brix domain Peptidase_S49_N PF08496.10 EKX72852.1 - 8.2 6.5 6.3 12 6.0 6.3 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Gaa1 PF04114.14 EKX72853.1 - 1.1e-29 103.8 13.8 3.1e-26 92.5 2.9 3.3 2 1 0 2 2 2 2 Gaa1-like, GPI transamidase component Vps36_ESCRT-II PF11605.8 EKX72854.1 - 0.1 12.8 0.0 0.24 11.6 0.0 1.7 2 0 0 2 2 2 0 Vacuolar protein sorting protein 36 Vps36 ERCC4 PF02732.15 EKX72855.1 - 1.9e-15 57.4 0.0 8.9e-15 55.2 0.0 2.3 2 0 0 2 2 2 1 ERCC4 domain DUF4130 PF13566.6 EKX72855.1 - 0.025 14.6 0.1 0.1 12.6 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4130 OSCP PF00213.18 EKX72855.1 - 0.99 9.5 4.0 12 6.0 0.1 3.6 4 0 0 4 4 4 0 ATP synthase delta (OSCP) subunit HA2 PF04408.23 EKX72856.1 - 4.1e-22 78.5 0.1 1.1e-20 73.9 0.0 2.7 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EKX72856.1 - 4.4e-16 59.0 0.0 1.1e-15 57.7 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EKX72856.1 - 6.6e-12 45.8 0.0 1.9e-11 44.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EKX72856.1 - 3e-06 27.1 0.0 6.2e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EKX72856.1 - 4e-06 27.1 0.0 1.1e-05 25.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EKX72856.1 - 0.00043 20.1 0.0 0.00081 19.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EKX72856.1 - 0.0028 17.7 0.1 1.7 8.6 0.0 2.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 EKX72856.1 - 0.0034 16.7 0.0 0.0072 15.6 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) SRP54 PF00448.22 EKX72856.1 - 0.0055 16.4 0.1 0.011 15.4 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_14 PF13173.6 EKX72856.1 - 0.0057 16.7 0.2 0.14 12.1 0.2 2.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EKX72856.1 - 0.0083 16.5 0.0 0.021 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EKX72856.1 - 0.016 15.7 0.0 0.057 13.9 0.0 2.0 1 0 0 1 1 1 0 ABC transporter T2SSE PF00437.20 EKX72856.1 - 0.045 12.8 0.0 0.13 11.3 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein Roc PF08477.13 EKX72856.1 - 0.047 13.9 0.2 3.5 7.9 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ATPase PF06745.13 EKX72856.1 - 0.049 13.0 0.7 0.17 11.2 0.0 2.1 2 0 0 2 2 2 0 KaiC E2R135 PF11570.8 EKX72856.1 - 0.1 12.9 0.1 0.1 12.9 0.1 3.0 3 1 1 4 4 3 0 Coiled-coil receptor-binding R-domain of colicin E2 AAA_33 PF13671.6 EKX72856.1 - 0.29 11.3 2.0 0.61 10.2 0.1 2.6 2 1 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EKX72856.1 - 0.7 10.4 0.0 0.7 10.4 0.0 3.4 3 1 0 3 3 2 0 AAA domain NUC173 PF08161.12 EKX72857.1 - 3.9e-13 49.5 0.0 1.5e-12 47.6 0.0 2.0 1 0 0 1 1 1 1 NUC173 domain CTD_bind PF04818.13 EKX72859.1 - 0.00092 20.0 0.2 0.0031 18.3 0.2 2.0 1 1 0 1 1 1 1 RNA polymerase II-binding domain. Vps16_C PF04840.12 EKX72860.1 - 0.0075 15.3 0.1 0.01 14.9 0.1 1.2 1 0 0 1 1 1 1 Vps16, C-terminal region TRCF PF03461.15 EKX72860.1 - 0.021 15.2 0.1 0.042 14.2 0.1 1.5 1 1 0 1 1 1 0 TRCF domain TMPIT PF07851.13 EKX72861.1 - 0.51 9.5 7.9 0.26 10.5 4.3 1.9 2 0 0 2 2 2 0 TMPIT-like protein DUF4602 PF15375.6 EKX72862.1 - 1.8e-05 25.1 13.6 3.2e-05 24.2 13.6 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4602) tRNA-synt_2 PF00152.20 EKX72863.1 - 4.7e-76 255.9 0.0 2.1e-59 201.2 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EKX72863.1 - 1.4e-10 41.0 0.0 3.4e-10 39.8 0.0 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EKX72863.1 - 1.5e-09 37.8 0.2 5.7e-05 22.7 0.0 3.0 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) LSM PF01423.22 EKX72864.1 - 3.5e-14 52.2 0.0 4.2e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EKX72864.1 - 0.029 14.0 0.0 0.044 13.4 0.0 1.4 1 0 0 1 1 1 0 Hfq protein DNA_pol_A_exo1 PF01612.20 EKX72865.1 - 1.5e-44 151.8 0.0 2.9e-44 150.9 0.0 1.5 1 0 0 1 1 1 1 3'-5' exonuclease YabA PF06156.13 EKX72865.1 - 0.03 14.9 0.2 2.5 8.8 0.0 3.2 3 0 0 3 3 3 0 Initiation control protein YabA MCD_N PF17408.2 EKX72866.1 - 0.093 12.9 0.1 0.34 11.1 0.1 2.1 1 1 1 2 2 2 0 Malonyl-CoA decarboxylase N-terminal domain ERCC4 PF02732.15 EKX72867.1 - 5.3e-22 78.7 0.0 9.6e-22 77.9 0.0 1.5 1 0 0 1 1 1 1 ERCC4 domain DrrA_P4M PF14860.6 EKX72868.1 - 0.3 10.9 5.8 0.082 12.8 0.7 2.4 2 1 0 2 2 2 0 DrrA phosphatidylinositol 4-phosphate binding domain Syntaxin_2 PF14523.6 EKX72868.1 - 0.39 11.1 12.3 0.04 14.3 4.4 2.4 2 1 0 2 2 2 0 Syntaxin-like protein Prp18 PF02840.15 EKX72868.1 - 0.45 10.6 2.9 1.9 8.5 0.6 2.7 2 1 1 3 3 3 0 Prp18 domain PIN_12 PF16289.5 EKX72868.1 - 2.4 8.6 11.3 1.4 9.4 3.1 2.5 2 1 0 2 2 2 0 PIN domain PCI PF01399.27 EKX72869.1 - 4.8 7.7 6.1 5.9 7.5 0.3 3.9 4 1 1 5 5 5 0 PCI domain DUF818 PF05677.12 EKX72870.1 - 0.0024 16.9 0.0 0.0024 16.9 0.0 1.9 2 0 0 2 2 2 1 Chlamydia CHLPS protein (DUF818) Xpo1 PF08389.12 EKX72872.1 - 0.00032 20.8 1.1 0.00032 20.8 1.1 4.3 5 0 0 5 5 5 1 Exportin 1-like protein TFIIB PF00382.19 EKX72873.1 - 1.7e-24 85.7 0.0 2.5e-12 46.6 0.0 2.6 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 EKX72873.1 - 1.5e-12 47.7 8.7 2.4e-12 47.1 7.9 1.7 2 0 0 2 2 2 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 EKX72873.1 - 3.3e-05 23.3 0.9 7.4e-05 22.2 0.9 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding A2L_zn_ribbon PF08792.10 EKX72873.1 - 0.00097 18.8 1.2 0.0037 16.9 1.2 2.1 1 0 0 1 1 1 1 A2L zinc ribbon domain DZR PF12773.7 EKX72873.1 - 0.093 12.8 0.6 0.28 11.3 0.6 1.7 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 EKX72873.1 - 0.27 11.0 2.0 9.1 6.1 0.0 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Spt5_N PF11942.8 EKX72873.1 - 6.8 7.7 8.9 16 6.5 8.9 1.6 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal YDG PF18657.1 EKX72874.1 - 0.07 13.3 1.2 0.13 12.5 0.0 2.0 3 0 0 3 3 3 0 YDG domain FAINT PF04385.15 EKX72875.1 - 0.0014 18.7 1.4 0.002 18.2 1.4 1.4 1 1 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 EKX72877.1 - 4.5e-14 52.3 16.7 1.6e-08 34.5 0.7 4.1 3 1 1 4 4 4 3 Domain of unknown function, DUF529 E1-E2_ATPase PF00122.20 EKX72878.1 - 1.1e-20 73.9 0.1 2.5e-20 72.8 0.1 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EKX72878.1 - 2.2e-13 51.0 0.0 8.1e-06 26.3 0.0 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase DUF1634 PF07843.11 EKX72878.1 - 0.13 12.3 4.3 1.5 8.9 0.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1634) MFS_1 PF07690.16 EKX72879.1 - 4.2e-11 42.4 28.2 5.8e-11 41.9 28.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DEAD PF00270.29 EKX72880.1 - 9.9e-36 123.1 0.0 1.5e-35 122.5 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKX72880.1 - 1.3e-26 93.2 0.2 1.7e-25 89.5 0.1 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain CMS1 PF14617.6 EKX72880.1 - 0.029 13.7 0.0 0.068 12.5 0.0 1.6 1 1 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DUF4844 PF16133.5 EKX72880.1 - 0.042 14.4 0.3 0.1 13.2 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4844) PITH PF06201.13 EKX72881.1 - 9e-27 94.1 1.0 1.1e-26 93.9 1.0 1.1 1 0 0 1 1 1 1 PITH domain ApeA_NTD1 PF18862.1 EKX72881.1 - 0.0054 16.3 0.1 0.0097 15.5 0.1 1.3 1 0 0 1 1 1 1 ApeA N-terminal domain 1 Ribosomal_L37ae PF01780.19 EKX72882.1 - 3.4e-38 129.6 4.8 3.8e-38 129.4 4.8 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.7 EKX72882.1 - 0.0001 22.2 2.4 0.00015 21.6 2.4 1.3 1 0 0 1 1 1 1 Transposase zinc-ribbon domain Lar_restr_allev PF14354.6 EKX72882.1 - 0.0058 17.0 0.9 0.0087 16.4 0.9 1.4 1 0 0 1 1 1 1 Restriction alleviation protein Lar OrfB_Zn_ribbon PF07282.11 EKX72882.1 - 0.016 15.2 0.5 0.025 14.5 0.5 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Elf1 PF05129.13 EKX72882.1 - 0.021 14.9 1.5 0.033 14.2 1.5 1.5 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-H2C2_2 PF13465.6 EKX72882.1 - 0.023 15.1 1.3 0.62 10.6 0.1 2.3 2 0 0 2 2 2 0 Zinc-finger double domain Sgf11 PF08209.11 EKX72882.1 - 0.063 12.9 0.5 2.4 7.8 0.1 2.2 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) zf-Di19 PF05605.12 EKX72882.1 - 0.088 13.1 0.1 0.18 12.1 0.1 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding C1_2 PF03107.16 EKX72882.1 - 0.4 11.0 2.8 9.4 6.7 3.1 2.1 1 1 1 2 2 2 0 C1 domain Zn-ribbon_8 PF09723.10 EKX72882.1 - 0.55 10.4 2.8 0.64 10.2 0.1 2.0 1 1 1 2 2 2 0 Zinc ribbon domain MRNIP PF15749.5 EKX72882.1 - 0.58 10.9 4.7 2.5 8.9 2.2 2.2 1 1 1 2 2 2 0 MRN-interacting protein A2L_zn_ribbon PF08792.10 EKX72882.1 - 0.68 9.7 4.5 2.2 8.1 0.1 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain SecE PF00584.20 EKX72883.1 - 7.2e-14 51.5 0.0 9.1e-14 51.1 0.0 1.2 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex SNF PF00209.18 EKX72884.1 - 1e-14 54.2 34.3 1.5e-14 53.6 34.3 1.2 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family TMCCDC2 PF15844.5 EKX72885.1 - 0.096 12.6 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 Transmembrane and coiled-coil domain-containing protein 2 Myb_DNA-bind_6 PF13921.6 EKX72885.1 - 0.12 12.7 0.0 0.31 11.3 0.0 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain DUF4061 PF13270.6 EKX72885.1 - 0.18 12.2 2.6 0.81 10.0 2.6 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4061) DED PF01335.21 EKX72885.1 - 0.88 9.9 4.6 3.6 7.9 0.2 3.9 4 0 0 4 4 4 0 Death effector domain MtrB PF05440.12 EKX72885.1 - 2 8.9 6.0 1.4 9.4 0.5 3.0 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase subunit B NAD_kinase PF01513.21 EKX72886.1 - 9.7e-59 198.9 0.0 1.3e-58 198.6 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EKX72886.1 - 0.0012 18.4 0.0 0.0026 17.4 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain YgbB PF02542.16 EKX72887.1 - 2.2e-54 183.9 0.1 2.9e-54 183.6 0.1 1.1 1 0 0 1 1 1 1 YgbB family MAGE PF01454.19 EKX72889.1 - 0.013 15.2 0.1 0.91 9.2 0.1 2.3 1 1 1 2 2 2 0 MAGE family Hydrolase_4 PF12146.8 EKX72890.1 - 5.6e-17 61.8 0.0 2.6e-10 40.0 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EKX72890.1 - 1.2e-06 28.4 0.2 0.0076 15.9 0.0 2.2 1 1 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EKX72890.1 - 0.00083 18.9 0.0 0.028 13.9 0.0 2.3 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_4 PF08386.10 EKX72890.1 - 0.0062 16.6 0.0 0.011 15.9 0.0 1.3 1 0 0 1 1 1 1 TAP-like protein FSH1 PF03959.13 EKX72890.1 - 0.012 15.3 0.0 0.019 14.6 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 EKX72890.1 - 0.027 15.1 0.0 0.052 14.2 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF5365 PF17326.2 EKX72890.1 - 0.063 13.7 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5365) Mt_ATP-synt_B PF05405.14 EKX72891.1 - 0.031 13.9 3.2 0.1 12.2 0.1 3.1 4 0 0 4 4 4 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Mito_carr PF00153.27 EKX72892.1 - 6.1e-63 208.8 4.5 5.9e-21 74.2 0.1 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF4199 PF13858.6 EKX72892.1 - 0.025 15.0 0.6 3.2 8.1 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) DUF2975 PF11188.8 EKX72892.1 - 0.14 12.1 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2975) Peptidase_C1 PF00112.23 EKX72895.1 - 1.4e-25 90.7 8.2 4.7e-20 72.6 8.7 3.0 2 1 0 2 2 2 2 Papain family cysteine protease CathepsinC_exc PF08773.11 EKX72895.1 - 3.3e-12 46.7 0.0 4.5e-11 43.1 0.0 2.5 1 1 0 1 1 1 1 Cathepsin C exclusion domain Peptidase_C1_2 PF03051.15 EKX72895.1 - 6.9e-06 25.1 0.4 0.0064 15.3 0.3 2.2 2 0 0 2 2 2 2 Peptidase C1-like family DUF2207 PF09972.9 EKX72897.1 - 0.048 12.4 0.1 0.058 12.2 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) AAA PF00004.29 EKX72899.1 - 5.9e-42 143.2 0.0 1.1e-41 142.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EKX72899.1 - 1e-17 63.8 0.0 1.6e-16 60.0 0.0 2.6 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 EKX72899.1 - 1.2e-17 63.7 3.3 3.1e-17 62.4 3.3 1.8 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 EKX72899.1 - 4.7e-09 35.9 0.0 1.4e-08 34.4 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 EKX72899.1 - 4.2e-06 26.6 0.0 8.2e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EKX72899.1 - 4.8e-06 26.8 0.0 8.8e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EKX72899.1 - 4e-05 24.1 0.0 0.0033 17.8 0.0 2.4 1 1 0 2 2 2 1 AAA ATPase domain AAA_24 PF13479.6 EKX72899.1 - 4.9e-05 23.1 0.0 9.4e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EKX72899.1 - 5.1e-05 23.3 0.0 0.00018 21.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EKX72899.1 - 5.6e-05 22.8 0.3 0.23 11.0 0.1 2.5 1 1 1 2 2 2 2 AAA domain AAA_22 PF13401.6 EKX72899.1 - 8.7e-05 22.8 0.3 0.091 13.0 0.0 2.8 2 1 1 3 3 2 1 AAA domain AAA_14 PF13173.6 EKX72899.1 - 0.0002 21.4 0.0 0.00068 19.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain Viral_Hsp90 PF03225.14 EKX72899.1 - 0.00054 18.6 0.2 0.00079 18.0 0.2 1.2 1 0 0 1 1 1 1 Viral heat shock protein Hsp90 homologue TIP49 PF06068.13 EKX72899.1 - 0.00064 19.0 0.0 0.0012 18.2 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 EKX72899.1 - 0.0014 18.4 0.0 0.003 17.3 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 EKX72899.1 - 0.0025 18.0 0.0 0.0048 17.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EKX72899.1 - 0.0028 17.0 0.1 0.55 9.5 0.0 2.4 1 1 1 2 2 2 1 KaiC Mg_chelatase PF01078.21 EKX72899.1 - 0.0037 16.7 0.0 0.0089 15.4 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EKX72899.1 - 0.0062 16.3 0.0 0.39 10.4 0.0 2.8 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_18 PF13238.6 EKX72899.1 - 0.0074 16.8 0.0 0.022 15.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EKX72899.1 - 0.01 15.4 0.0 0.025 14.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EKX72899.1 - 0.01 16.2 0.0 0.028 14.8 0.0 1.9 1 0 0 1 1 1 0 RNA helicase PhoH PF02562.16 EKX72899.1 - 0.014 14.9 0.3 0.037 13.5 0.1 1.8 2 0 0 2 2 2 0 PhoH-like protein Parvo_NS1 PF01057.17 EKX72899.1 - 0.024 13.7 0.0 0.04 13.0 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF815 PF05673.13 EKX72899.1 - 0.044 12.9 0.0 0.074 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_17 PF13207.6 EKX72899.1 - 0.046 14.1 0.0 0.091 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 EKX72899.1 - 0.061 12.7 0.0 8.1 5.8 0.0 2.5 1 1 1 2 2 2 0 Bacterial TniB protein TsaE PF02367.17 EKX72899.1 - 0.065 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF4417 PF14386.6 EKX72899.1 - 0.067 12.8 0.2 0.61 9.6 0.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4417) KdpD PF02702.17 EKX72899.1 - 0.091 12.2 0.1 1.3 8.5 0.0 2.4 2 1 1 3 3 3 0 Osmosensitive K+ channel His kinase sensor domain ResIII PF04851.15 EKX72899.1 - 0.1 12.6 0.0 0.28 11.2 0.0 1.8 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit NACHT PF05729.12 EKX72899.1 - 0.16 11.9 0.0 0.82 9.6 0.0 2.0 2 0 0 2 2 2 0 NACHT domain TPR_12 PF13424.6 EKX72899.1 - 0.17 12.2 1.3 1.4 9.3 0.3 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EKX72899.1 - 0.65 9.9 3.4 2.8 7.9 3.1 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EKX72899.1 - 1.2 9.4 6.5 0.62 10.3 2.5 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat Pro_isomerase PF00160.21 EKX72900.1 - 1.6e-50 171.4 0.0 1.9e-50 171.2 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 EKX72901.1 - 0.038 14.9 10.8 0.1 13.5 0.0 4.5 6 0 0 6 6 6 0 WD domain, G-beta repeat STT3 PF02516.14 EKX72902.1 - 3.7e-52 177.9 35.5 3.7e-51 174.6 35.5 2.4 1 1 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit BT1 PF03092.16 EKX72903.1 - 8.8e-46 156.2 19.1 1.5e-26 92.8 8.6 2.0 1 1 1 2 2 2 2 BT1 family MFS_1 PF07690.16 EKX72903.1 - 3.5e-12 45.9 50.2 5.9e-10 38.6 27.6 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF5391 PF17369.2 EKX72903.1 - 0.61 10.1 9.1 0.11 12.5 3.8 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5391) DUF676 PF05057.14 EKX72904.1 - 1.9e-11 43.9 0.2 1.3e-09 37.9 0.2 2.9 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 EKX72904.1 - 0.00039 20.3 0.0 0.26 11.1 0.0 2.5 2 1 0 2 2 2 2 Palmitoyl protein thioesterase PGI PF00342.19 EKX72905.1 - 2e-168 561.0 0.0 2.4e-168 560.7 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Hydrolase_4 PF12146.8 EKX72906.1 - 7.2e-20 71.3 0.1 4e-19 68.8 0.0 2.2 2 1 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX72906.1 - 9.4e-11 41.6 10.4 0.0041 17.1 0.0 6.4 5 1 0 5 5 5 3 Domain of unknown function, DUF529 Abhydrolase_6 PF12697.7 EKX72906.1 - 6e-06 27.0 0.0 1.4e-05 25.8 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EKX72906.1 - 0.00057 19.6 1.5 0.0099 15.5 1.5 2.6 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 EKX72906.1 - 0.0034 17.5 0.0 0.01 15.9 0.0 1.8 2 0 0 2 2 2 1 TAP-like protein DUF676 PF05057.14 EKX72906.1 - 0.0072 15.9 0.0 0.014 14.9 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_2 PF02230.16 EKX72906.1 - 0.014 15.2 0.2 6.5 6.5 0.0 2.9 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EKX72906.1 - 0.063 12.7 0.1 0.57 9.6 0.0 2.4 2 0 0 2 2 2 0 Prolyl oligopeptidase family WGG PF10273.9 EKX72908.1 - 4.1e-16 59.4 0.3 9.7e-16 58.2 0.3 1.6 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 PIG-U PF06728.13 EKX72908.1 - 2e-14 53.5 30.4 1.5e-13 50.6 30.4 2.1 1 1 0 1 1 1 1 GPI transamidase subunit PIG-U ER_lumen_recept PF00810.18 EKX72909.1 - 1.5e-32 113.5 8.5 1.5e-32 113.5 8.5 2.4 3 0 0 3 3 3 1 ER lumen protein retaining receptor Cytomega_TRL10 PF06084.11 EKX72909.1 - 0.79 9.7 3.8 5.1 7.1 0.7 2.4 1 1 1 2 2 2 0 Cytomegalovirus TRL10 protein CLTH PF10607.9 EKX72910.1 - 2.6e-13 50.1 2.5 9e-13 48.4 0.1 2.3 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain TniQ PF06527.11 EKX72910.1 - 0.0013 19.5 0.0 0.0085 16.8 0.0 2.1 2 0 0 2 2 2 1 TniQ DUF5446 PF17522.2 EKX72910.1 - 0.24 11.6 2.9 1.8 8.8 0.6 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5446) Cep57_CLD_2 PF14197.6 EKX72910.1 - 0.24 11.5 4.6 0.96 9.6 4.7 2.0 1 1 0 1 1 1 0 Centrosome localisation domain of PPC89 DUF3834 PF12916.7 EKX72910.1 - 0.43 9.8 5.2 0.76 9.0 2.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3834) MFS_1 PF07690.16 EKX72911.1 - 5.1e-19 68.4 29.7 5.1e-19 68.4 29.7 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 EKX72911.1 - 1.5e-11 43.3 29.5 2.9e-06 25.9 2.8 4.1 2 2 2 4 4 4 4 Organic Anion Transporter Polypeptide (OATP) family Sugar_tr PF00083.24 EKX72911.1 - 8.8e-07 28.1 15.3 8.8e-07 28.1 15.3 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter Arf PF00025.21 EKX72912.1 - 1.4e-15 57.2 0.0 1.8e-14 53.5 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKX72912.1 - 5.4e-06 26.1 0.0 0.00097 18.7 0.0 2.2 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Roc PF08477.13 EKX72912.1 - 0.001 19.3 0.2 0.25 11.6 0.1 2.3 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EKX72912.1 - 0.0011 18.3 0.7 0.079 12.3 0.7 2.1 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EKX72912.1 - 0.0097 16.0 0.1 0.16 12.0 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase Zeta_toxin PF06414.12 EKX72912.1 - 0.042 13.1 0.0 0.072 12.4 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin ABC_tran PF00005.27 EKX72912.1 - 0.12 12.9 0.1 0.22 12.1 0.1 1.7 1 1 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 EKX72912.1 - 0.14 11.9 0.0 4.3 7.2 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_23 PF13476.6 EKX72912.1 - 0.7 10.4 0.1 0.7 10.4 0.1 1.8 1 1 0 2 2 2 0 AAA domain RRM_1 PF00076.22 EKX72914.1 - 9.8e-15 54.1 0.6 1.8e-14 53.3 0.1 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EKX72914.1 - 0.14 11.7 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) UQ_con PF00179.26 EKX72915.1 - 5.8e-49 165.3 0.0 6.7e-49 165.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EKX72915.1 - 0.11 12.3 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B DNA_pol_P_Exo PF18049.1 EKX72915.1 - 0.11 11.9 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase nu pseudo-exo Nudc_N PF14050.6 EKX72916.1 - 2e-17 62.9 2.3 3.1e-17 62.3 2.3 1.3 1 0 0 1 1 1 1 N-terminal conserved domain of Nudc. CS PF04969.16 EKX72916.1 - 7.7e-13 49.3 2.1 9.5e-13 49.0 1.0 1.7 2 0 0 2 2 2 1 CS domain Ribosomal_L18_c PF14204.6 EKX72916.1 - 1.4 9.9 4.1 0.64 11.0 0.9 2.1 2 1 0 2 2 2 0 Ribosomal L18 C-terminal region PHM7_cyt PF14703.6 EKX72917.1 - 0.00013 22.3 0.9 0.0029 17.8 0.2 2.4 1 1 1 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter CoxIIa PF08113.11 EKX72917.1 - 7.1 6.5 8.8 0.23 11.3 1.9 2.2 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IIa family ArfGap PF01412.18 EKX72918.1 - 1.6 8.8 5.3 5.1 7.2 5.3 1.9 1 1 0 1 1 1 0 Putative GTPase activating protein for Arf Dynein_light PF01221.18 EKX72919.1 - 0.13 12.6 0.4 0.56 10.6 0.0 2.1 2 0 0 2 2 2 0 Dynein light chain type 1 zf-RanBP PF00641.18 EKX72920.1 - 4.2e-05 22.8 6.9 0.00012 21.4 6.9 1.8 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others zf-U1 PF06220.12 EKX72921.1 - 4e-19 68.1 2.7 5.3e-19 67.7 2.7 1.2 1 0 0 1 1 1 1 U1 zinc finger Ribosomal_L12_N PF16320.5 EKX72922.1 - 2.7e-14 52.6 2.3 2.7e-14 52.6 2.3 2.0 2 0 0 2 2 2 1 Ribosomal protein L7/L12 dimerisation domain Ribosomal_L12 PF00542.19 EKX72922.1 - 2.3e-08 34.3 2.0 6.1e-08 32.9 0.2 2.2 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain EIIBC-GUT_N PF03612.14 EKX72922.1 - 0.014 15.2 0.8 0.15 11.8 1.1 2.0 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Ribosomal_60s PF00428.19 EKX72922.1 - 0.027 15.0 4.2 0.027 15.0 4.2 1.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF3682 PF12446.8 EKX72922.1 - 0.18 12.3 3.9 0.28 11.6 3.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) DUF2730 PF10805.8 EKX72924.1 - 0.06 13.4 6.7 0.095 12.8 3.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) TMPIT PF07851.13 EKX72924.1 - 2.4 7.4 6.3 18 4.5 3.0 2.1 2 0 0 2 2 2 0 TMPIT-like protein Atg14 PF10186.9 EKX72924.1 - 7.4 5.6 12.8 1.2 8.1 9.2 1.5 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DivIC PF04977.15 EKX72924.1 - 9.5 6.1 12.1 36 4.2 0.1 3.8 3 1 1 4 4 4 0 Septum formation initiator CS PF04969.16 EKX72925.1 - 6e-10 40.0 5.5 1.6e-09 38.6 4.4 2.4 2 0 0 2 2 2 1 CS domain BORCS7 PF16088.5 EKX72925.1 - 0.22 11.8 2.5 0.67 10.2 2.5 1.9 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 7 Spore_III_AB PF09548.10 EKX72925.1 - 1.2 9.2 9.2 0.36 10.9 2.6 3.2 3 1 1 4 4 4 0 Stage III sporulation protein AB (spore_III_AB) HSCB_C PF07743.13 EKX72926.1 - 3.1e-06 27.6 0.0 9.5e-06 26.0 0.0 1.9 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 EKX72926.1 - 0.00055 20.0 1.8 0.00096 19.2 0.8 2.0 2 0 0 2 2 2 1 DnaJ domain 4HB_MCP_1 PF12729.7 EKX72926.1 - 0.64 9.5 5.4 1.3 8.5 0.2 2.2 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction Biotin_lipoyl PF00364.22 EKX72927.1 - 2.2e-11 43.4 0.1 3.8e-11 42.7 0.1 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme GCV_H PF01597.19 EKX72927.1 - 0.00035 20.5 0.2 0.0016 18.4 0.0 1.8 1 1 1 2 2 2 1 Glycine cleavage H-protein Biotin_lipoyl_2 PF13533.6 EKX72927.1 - 0.023 14.5 0.1 0.081 12.8 0.0 1.9 3 0 0 3 3 3 0 Biotin-lipoyl like Aldo_ket_red PF00248.21 EKX72928.1 - 3.4e-55 187.3 0.0 5.3e-55 186.7 0.0 1.3 1 0 0 1 1 1 1 Aldo/keto reductase family Citrate_synt PF00285.21 EKX72929.1 - 1e-22 80.7 0.0 1.5e-22 80.2 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Citrate_synt PF00285.21 EKX72930.1 - 0.002 17.3 0.0 0.0022 17.2 0.0 1.2 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain RRM_1 PF00076.22 EKX72932.1 - 8.1e-05 22.4 0.0 0.00016 21.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.25 EKX72933.1 - 1.3e-28 100.1 0.0 1.7e-28 99.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKX72933.1 - 9.5e-17 61.1 0.0 1.3e-16 60.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKX72933.1 - 7.6e-09 34.8 0.1 1e-08 34.4 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EKX72933.1 - 8.5e-05 22.6 0.0 0.0014 18.6 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EKX72933.1 - 0.015 14.3 0.2 0.015 14.3 0.2 1.6 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase SMC_N PF02463.19 EKX72935.1 - 8e-42 143.1 39.0 3e-39 134.7 39.0 4.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EKX72935.1 - 6.4e-20 71.6 0.1 2.1e-19 69.9 0.1 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 EKX72935.1 - 2.1e-17 64.3 0.8 2.1e-17 64.3 0.8 7.1 1 1 3 4 4 4 1 AAA domain AAA_21 PF13304.6 EKX72935.1 - 5.6e-13 49.4 1.4 3.7e-08 33.6 0.2 3.9 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EKX72935.1 - 0.00011 21.9 0.0 0.00029 20.5 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 EKX72935.1 - 0.0047 16.7 109.6 0.15 11.7 12.6 4.8 1 1 1 2 2 2 1 AAA ATPase domain FlxA PF14282.6 EKX72935.1 - 0.0094 15.9 8.6 0.0094 15.9 8.6 8.0 4 2 3 7 7 7 2 FlxA-like protein DUF3584 PF12128.8 EKX72935.1 - 0.06 10.9 75.3 0.099 10.1 36.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) BSD PF03909.17 EKX72935.1 - 0.1 12.6 4.4 0.23 11.5 0.0 4.1 4 0 0 4 4 4 0 BSD domain ABC_tran PF00005.27 EKX72935.1 - 0.45 11.0 0.0 0.45 11.0 0.0 6.4 4 2 1 5 5 5 0 ABC transporter PPR_3 PF13812.6 EKX72936.1 - 0.14 12.2 0.0 3.4 7.8 0.0 2.8 2 0 0 2 2 2 0 Pentatricopeptide repeat domain PPR PF01535.20 EKX72936.1 - 0.18 12.1 0.7 1.7 9.1 0.1 2.8 2 0 0 2 2 2 0 PPR repeat FAINT PF04385.15 EKX72937.1 - 2.5e-08 33.9 4.8 2.8e-07 30.5 0.2 3.4 2 1 2 4 4 4 1 Domain of unknown function, DUF529 FmdE PF02663.14 EKX72937.1 - 0.12 12.5 0.0 3.3 7.7 0.0 2.2 1 1 1 2 2 2 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon Methyltransf_8 PF05148.15 EKX72938.1 - 3.7e-70 236.2 0.0 4.7e-70 235.9 0.0 1.1 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 EKX72938.1 - 0.00059 20.4 0.1 0.0091 16.6 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EKX72938.1 - 0.0031 17.1 0.0 0.093 12.3 0.0 2.3 1 1 1 2 2 2 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EKX72938.1 - 0.0067 17.1 0.0 1 10.1 0.0 2.5 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 EKX72938.1 - 0.038 13.8 0.0 0.15 11.9 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain Elong-fact-P_C PF09285.11 EKX72939.1 - 5.9e-11 41.9 0.2 1.9e-10 40.4 0.2 1.9 1 0 0 1 1 1 1 Elongation factor P, C-terminal EFP_N PF08207.12 EKX72939.1 - 0.00021 21.2 0.1 0.00064 19.7 0.1 1.9 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain EFP PF01132.20 EKX72939.1 - 0.044 13.8 0.0 0.15 12.1 0.0 2.0 1 1 1 2 2 2 0 Elongation factor P (EF-P) OB domain Asp PF00026.23 EKX72940.1 - 2.2e-60 204.7 0.0 4.4e-60 203.7 0.0 1.4 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EKX72940.1 - 1.2e-07 32.1 0.2 7.1e-06 26.4 0.0 2.4 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Lge1 PF11488.8 EKX72941.1 - 0.021 15.0 2.7 4.3 7.6 0.4 3.3 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 Rad50_zn_hook PF04423.14 EKX72941.1 - 0.024 14.5 1.6 0.047 13.5 0.1 2.3 2 0 0 2 2 2 0 Rad50 zinc hook motif zinc_ribbon_13 PF09855.9 EKX72941.1 - 0.22 11.7 2.0 2.8 8.2 0.1 2.9 2 0 0 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) Arv1 PF04161.13 EKX72943.1 - 1.5e-23 84.1 17.5 2.1e-21 77.0 17.5 2.4 1 1 0 1 1 1 1 Arv1-like family Sigma_reg_N PF13800.6 EKX72943.1 - 0.058 13.7 0.5 0.058 13.7 0.5 3.5 4 1 1 5 5 5 0 Sigma factor regulator N-terminal RF-1 PF00472.20 EKX72944.1 - 1.3e-27 96.0 2.9 1.5e-27 95.8 1.4 1.8 2 0 0 2 2 2 1 RF-1 domain PCRF PF03462.18 EKX72944.1 - 2.9e-18 66.4 3.6 9.7e-18 64.7 0.8 2.7 2 1 0 2 2 2 1 PCRF domain Plk4_PB2 PF18409.1 EKX72944.1 - 0.063 14.0 2.5 0.9 10.2 0.1 3.1 3 0 0 3 3 3 0 Polo-like Kinase 4 Polo Box 2 SEP PF08059.13 EKX72945.1 - 6.4e-17 61.9 0.5 1.3e-16 60.9 0.1 1.7 2 0 0 2 2 2 1 SEP domain UBX PF00789.20 EKX72945.1 - 2.1e-06 27.8 0.0 7.8e-06 26.0 0.0 2.0 2 0 0 2 2 2 1 UBX domain Ribosomal_S6 PF01250.17 EKX72945.1 - 6.3e-06 26.4 0.0 1.4e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S6 RRM_9 PF18444.1 EKX72945.1 - 0.00098 18.9 0.1 0.0021 17.9 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif PQQ PF01011.21 EKX72946.1 - 0.13 12.2 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 PQQ enzyme repeat CAML PF14963.6 EKX72947.1 - 9.9 6.2 10.7 23 5.0 10.6 1.6 1 1 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand Pkinase PF00069.25 EKX72948.1 - 2.7e-35 122.0 0.0 8.3e-35 120.4 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKX72948.1 - 1.2e-22 80.4 0.0 1.2e-21 77.2 0.0 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 EKX72948.1 - 0.016 14.2 0.1 0.016 14.2 0.1 1.5 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase APH PF01636.23 EKX72948.1 - 0.018 15.0 0.0 0.029 14.3 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF3361 PF11841.8 EKX72949.1 - 0.055 13.4 0.3 0.13 12.1 0.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3361) zf-CCCH PF00642.24 EKX72950.1 - 2.7e-11 43.1 13.4 5.3e-06 26.2 1.8 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EKX72950.1 - 2.7e-05 24.8 1.2 0.15 12.8 0.1 2.4 2 0 0 2 2 2 2 Torus domain zf_CCCH_4 PF18345.1 EKX72950.1 - 4.4e-05 23.4 15.9 0.011 15.8 5.7 2.5 2 0 0 2 2 2 2 Zinc finger domain RRM_1 PF00076.22 EKX72950.1 - 0.00039 20.2 0.0 0.0013 18.5 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Stealth_CR3 PF17102.5 EKX72950.1 - 0.012 15.5 0.5 0.012 15.5 0.5 1.8 2 0 0 2 2 2 0 Stealth protein CR3, conserved region 3 zf-CCCH_3 PF15663.5 EKX72950.1 - 0.02 15.1 2.3 4.5 7.5 0.3 2.3 2 0 0 2 2 2 0 Zinc-finger containing family zf-CCCH_4 PF18044.1 EKX72950.1 - 1.4 8.8 15.7 3 7.7 6.6 2.4 2 0 0 2 2 2 0 CCCH-type zinc finger Proteasome PF00227.26 EKX72951.1 - 1.5e-36 125.7 0.0 3e-36 124.7 0.0 1.5 1 1 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EKX72951.1 - 4.4e-14 51.8 0.1 7e-14 51.2 0.1 1.3 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature PROCN PF08083.11 EKX72952.1 - 2.5e-222 737.9 7.9 3.7e-222 737.3 7.9 1.2 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 EKX72952.1 - 8.4e-121 401.8 0.2 1.5e-120 401.0 0.2 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 EKX72952.1 - 5.1e-88 293.0 4.1 1.4e-87 291.6 4.1 1.8 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 EKX72952.1 - 2.8e-84 280.6 3.9 7.5e-84 279.2 3.9 1.8 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 EKX72952.1 - 9.5e-72 239.4 0.0 1.9e-71 238.4 0.0 1.5 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 EKX72952.1 - 5.9e-45 151.5 0.7 1.5e-44 150.3 0.7 1.7 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 EKX72952.1 - 2.1e-30 105.2 0.1 6.9e-30 103.5 0.1 2.0 1 0 0 1 1 1 1 PROCT (NUC072) domain EamA PF00892.20 EKX72953.1 - 1.3e-07 31.9 2.0 1.3e-07 31.9 2.0 2.5 2 1 0 2 2 2 1 EamA-like transporter family Asp-Al_Ex PF06826.12 EKX72953.1 - 0.00053 19.8 3.5 0.046 13.6 2.0 2.3 1 1 1 2 2 2 2 Predicted Permease Membrane Region PUNUT PF16913.5 EKX72953.1 - 0.0025 17.1 3.6 0.0035 16.6 1.8 1.7 1 1 1 2 2 2 1 Purine nucleobase transmembrane transport PhaG_MnhG_YufB PF03334.14 EKX72953.1 - 0.9 9.8 7.5 0.087 13.1 1.6 2.3 2 1 0 2 2 2 0 Na+/H+ antiporter subunit AAA PF00004.29 EKX72955.1 - 5.2e-08 33.4 0.0 7.8e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 EKX72956.1 - 3.7e-23 81.8 0.3 1.2e-20 73.7 0.1 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase KH_dom-like PF14714.6 EKX72956.1 - 1e-21 77.0 0.0 3.9e-21 75.2 0.0 2.0 2 0 0 2 2 2 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal FeoB_N PF02421.18 EKX72956.1 - 4.6e-07 29.5 0.0 2.5e-06 27.1 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EKX72956.1 - 8.4e-06 25.8 0.5 0.0021 18.0 0.2 2.5 2 0 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 EKX72956.1 - 0.00014 21.3 0.1 0.00025 20.4 0.1 1.4 1 0 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.27 EKX72956.1 - 0.00014 21.4 0.0 0.92 9.0 0.1 3.9 2 2 0 2 2 2 2 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EKX72956.1 - 0.0034 16.8 0.1 0.15 11.5 0.0 3.0 3 0 0 3 3 3 1 Signal recognition particle receptor beta subunit HLH PF00010.26 EKX72956.1 - 0.017 15.1 1.4 0.1 12.6 0.8 2.4 2 0 0 2 2 2 0 Helix-loop-helix DNA-binding domain Dynamin_N PF00350.23 EKX72956.1 - 0.11 12.6 2.0 0.6 10.2 0.2 2.8 3 0 0 3 3 3 0 Dynamin family Roc PF08477.13 EKX72956.1 - 0.12 12.5 0.2 0.89 9.8 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SCAMP PF04144.13 EKX72958.1 - 4.5e-06 27.1 0.2 5.8e-06 26.7 0.2 1.1 1 0 0 1 1 1 1 SCAMP family BolA PF01722.18 EKX72959.1 - 0.029 14.6 0.0 0.041 14.2 0.0 1.3 1 0 0 1 1 1 0 BolA-like protein Peptidase_C1 PF00112.23 EKX72960.1 - 8.7e-60 202.5 0.7 1.3e-59 201.9 0.7 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EKX72960.1 - 3.8e-07 30.5 4.6 3.8e-07 30.4 3.0 2.0 2 0 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EKX72960.1 - 3.5e-05 22.8 0.3 0.0045 15.8 0.1 2.2 2 0 0 2 2 2 2 Peptidase C1-like family GTP_EFTU PF00009.27 EKX72961.1 - 8.4e-45 152.7 0.1 1.5e-44 151.8 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EKX72961.1 - 9.3e-08 32.0 0.1 2.3e-07 30.8 0.1 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.23 EKX72961.1 - 1.5e-05 25.0 0.1 3.3e-05 23.9 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 EKX72961.1 - 0.0016 17.8 1.0 0.013 14.8 0.1 2.1 2 0 0 2 2 2 1 Septin AIG1 PF04548.16 EKX72961.1 - 0.012 15.0 0.0 0.025 13.9 0.0 1.5 1 0 0 1 1 1 0 AIG1 family GTP_EFTU_D2 PF03144.25 EKX72961.1 - 0.024 15.0 0.7 0.1 13.0 0.2 2.2 2 0 0 2 2 2 0 Elongation factor Tu domain 2 EFG_II PF14492.6 EKX72961.1 - 0.026 14.6 0.0 0.058 13.5 0.0 1.6 1 0 0 1 1 1 0 Elongation Factor G, domain II FeoB_N PF02421.18 EKX72961.1 - 0.12 11.9 0.1 0.47 10.0 0.1 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B ATP-synt_Eps PF04627.13 EKX72962.1 - 2.7e-15 56.1 0.0 3.5e-15 55.7 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain MIF4G PF02854.19 EKX72965.1 - 7.6e-24 84.5 2.2 9.4e-24 84.2 2.2 1.1 1 0 0 1 1 1 1 MIF4G domain ANAPC4_WD40 PF12894.7 EKX72966.1 - 9.3e-05 22.7 0.0 0.16 12.3 0.0 3.8 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EKX72966.1 - 0.019 15.0 0.1 26 4.9 0.0 3.6 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.32 EKX72966.1 - 0.25 12.3 11.0 45 5.1 0.0 5.3 7 0 0 7 7 7 0 WD domain, G-beta repeat PsbU PF06514.11 EKX72968.1 - 0.014 15.4 0.2 4.4 7.3 0.0 2.5 2 0 0 2 2 2 0 Photosystem II 12 kDa extrinsic protein (PsbU) tRNA_anti-codon PF01336.25 EKX72968.1 - 0.053 13.5 0.1 0.12 12.4 0.1 1.6 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain Frataxin_Cyay PF01491.16 EKX72969.1 - 4.5e-20 71.7 2.4 5.6e-20 71.4 0.3 2.4 2 0 0 2 2 2 1 Frataxin-like domain Ribosomal_L2_C PF03947.18 EKX72970.1 - 3.3e-46 156.6 0.2 4.8e-46 156.0 0.2 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EKX72970.1 - 7.1e-25 86.8 0.3 1.5e-24 85.7 0.3 1.6 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain PRP38 PF03371.15 EKX72971.1 - 4.4e-57 192.7 0.0 5e-57 192.6 0.0 1.0 1 0 0 1 1 1 1 PRP38 family CKS PF01111.19 EKX72972.1 - 1.7e-20 73.0 0.1 5.3e-20 71.5 0.1 1.9 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit HMD PF03201.16 EKX72973.1 - 0.1 12.8 0.0 17 5.7 0.0 2.4 2 0 0 2 2 2 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase RhoGEF PF00621.20 EKX72973.1 - 0.14 12.4 2.4 0.29 11.4 1.6 1.7 1 1 1 2 2 2 0 RhoGEF domain S1-P1_nuclease PF02265.16 EKX72974.1 - 5.9e-11 42.7 0.0 1.1e-06 28.7 0.0 2.1 2 0 0 2 2 2 2 S1/P1 Nuclease ACR_tran PF00873.19 EKX72974.1 - 0.29 8.7 0.2 0.39 8.3 0.2 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family FAINT PF04385.15 EKX72976.1 - 1.2e-18 67.0 18.6 6.9e-06 26.0 2.3 5.2 5 0 0 5 5 5 4 Domain of unknown function, DUF529 Hydrolase_4 PF12146.8 EKX72976.1 - 1e-14 54.4 0.0 5.3e-14 52.1 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EKX72976.1 - 0.00032 20.4 0.0 0.39 10.3 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EKX72976.1 - 0.07 12.9 0.1 1.3 8.8 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Autophagy_act_C PF03987.15 EKX72977.1 - 5.5e-13 49.3 0.1 1e-12 48.4 0.1 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_N PF03986.13 EKX72977.1 - 0.0042 17.0 0.0 0.0058 16.6 0.0 1.2 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain DUF2080 PF09853.9 EKX72977.1 - 0.17 11.7 0.0 0.35 10.6 0.0 1.5 1 0 0 1 1 1 0 Putative transposon-encoded protein (DUF2080) RabGAP-TBC PF00566.18 EKX72978.1 - 6.9e-55 186.0 0.5 9.2e-55 185.6 0.5 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain POTRA_TamA_1 PF17243.2 EKX72978.1 - 0.15 12.2 0.1 0.34 11.0 0.1 1.5 1 0 0 1 1 1 0 POTRA domain TamA domain 1 ATP_bind_3 PF01171.20 EKX72979.1 - 2.1e-30 105.8 3.6 2e-18 66.8 0.1 3.3 2 1 0 2 2 2 2 PP-loop family Acatn PF13000.7 EKX72980.1 - 1.1e-82 278.4 14.7 4.3e-69 233.5 4.0 2.1 1 1 1 2 2 2 2 Acetyl-coenzyme A transporter 1 CinA PF02464.17 EKX72981.1 - 0.0024 17.4 0.7 0.0044 16.6 0.7 1.4 1 0 0 1 1 1 1 Competence-damaged protein RRM_1 PF00076.22 EKX72981.1 - 0.05 13.4 0.0 0.18 11.6 0.0 1.9 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATP_bind_1 PF03029.17 EKX72983.1 - 3.2e-59 200.6 0.0 1.7e-43 149.1 0.0 3.0 2 1 0 2 2 2 2 Conserved hypothetical ATP binding protein PhoH PF02562.16 EKX72983.1 - 0.00094 18.7 0.0 0.21 11.0 0.0 2.2 2 0 0 2 2 2 2 PhoH-like protein AAA_18 PF13238.6 EKX72983.1 - 0.0015 19.1 0.0 0.0031 18.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain CLP1_P PF16575.5 EKX72983.1 - 0.017 14.9 0.0 0.035 13.9 0.0 1.5 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_22 PF13401.6 EKX72983.1 - 0.025 14.8 0.0 0.053 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EKX72983.1 - 0.052 13.3 0.0 0.079 12.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EKX72983.1 - 0.056 13.8 0.0 0.2 12.0 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain AAA_24 PF13479.6 EKX72983.1 - 0.084 12.6 0.0 0.5 10.1 0.0 2.3 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 EKX72983.1 - 0.087 13.0 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain PRK PF00485.18 EKX72983.1 - 0.094 12.4 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_7 PF12775.7 EKX72983.1 - 0.12 11.9 0.0 0.25 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 EKX72983.1 - 0.12 12.4 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EKX72983.1 - 0.15 11.9 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DUF4598 PF15370.6 EKX72984.1 - 0.043 14.3 0.0 0.096 13.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4598) DEAD PF00270.29 EKX72985.1 - 1.2e-14 54.5 0.0 7.5e-14 51.9 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKX72985.1 - 2.9e-12 46.9 0.3 5.7e-11 42.8 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain Peptidase_S76 PF13611.6 EKX72985.1 - 0.13 12.6 0.3 0.29 11.5 0.3 1.6 1 0 0 1 1 1 0 Serine peptidase of plant viral polyprotein, P1 ECH_2 PF16113.5 EKX72986.1 - 4.1e-23 82.4 0.0 7e-23 81.6 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EKX72986.1 - 3.2e-07 29.9 0.0 2.6e-06 27.0 0.0 2.1 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase GRASP55_65 PF04495.14 EKX72987.1 - 3.1e-52 176.5 0.1 4.5e-43 146.9 0.1 2.1 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.6 EKX72987.1 - 2.3e-10 40.6 0.0 7.6e-05 23.0 0.0 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 EKX72987.1 - 3.9e-06 26.6 0.0 0.057 13.3 0.0 3.1 2 1 0 2 2 2 2 PDZ domain PDZ PF00595.24 EKX72987.1 - 0.014 15.7 0.0 1.4 9.3 0.0 2.4 2 0 0 2 2 2 0 PDZ domain DUF502 PF04367.13 EKX72987.1 - 0.12 12.3 0.1 14 5.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF502) Cons_hypoth95 PF03602.15 EKX72990.1 - 2e-35 122.1 0.0 3.3e-35 121.4 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_31 PF13847.6 EKX72990.1 - 1e-05 25.4 0.0 1.5e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EKX72990.1 - 5.9e-05 22.7 0.0 0.00011 21.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EKX72990.1 - 9.6e-05 23.0 0.0 0.00027 21.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_15 PF09445.10 EKX72990.1 - 0.0013 18.3 0.1 0.0053 16.4 0.0 1.9 2 0 0 2 2 2 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 EKX72990.1 - 0.013 14.9 0.0 0.042 13.3 0.0 1.8 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) UPF0020 PF01170.18 EKX72990.1 - 0.031 14.0 0.1 0.73 9.5 0.1 2.2 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 MethyltransfD12 PF02086.15 EKX72990.1 - 0.058 13.1 0.0 0.16 11.6 0.0 1.7 1 1 0 1 1 1 0 D12 class N6 adenine-specific DNA methyltransferase DNA_methylase PF00145.17 EKX72990.1 - 0.084 12.2 0.3 0.17 11.2 0.1 1.6 2 0 0 2 2 2 0 C-5 cytosine-specific DNA methylase Mannosyl_trans2 PF04188.13 EKX72991.1 - 1.4e-15 57.6 32.8 1.4e-13 51.0 26.4 2.7 2 1 0 2 2 2 2 Mannosyltransferase (PIG-V) DNA_pol_phi PF04931.13 EKX72992.1 - 2.6e-10 39.1 0.0 2.6e-10 39.1 0.0 4.3 3 1 0 4 4 4 1 DNA polymerase phi Nop14 PF04147.12 EKX72992.1 - 0.0024 16.2 27.3 0.0042 15.4 21.7 2.3 2 0 0 2 2 2 1 Nop14-like family Mpp10 PF04006.12 EKX72992.1 - 0.003 16.1 18.9 0.0048 15.4 18.9 1.2 1 0 0 1 1 1 1 Mpp10 protein SDA1 PF05285.12 EKX72992.1 - 0.0071 15.8 22.0 0.013 15.0 22.0 1.3 1 0 0 1 1 1 1 SDA1 AAR2 PF05282.11 EKX72992.1 - 0.012 15.0 1.4 0.033 13.6 1.4 1.7 1 0 0 1 1 1 0 AAR2 protein CDC45 PF02724.14 EKX72992.1 - 0.018 13.4 17.2 0.032 12.6 17.2 1.3 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_Rpc4 PF05132.14 EKX72992.1 - 0.024 15.1 4.5 0.05 14.0 4.5 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 DDHD PF02862.17 EKX72992.1 - 0.046 13.9 2.1 0.12 12.5 1.5 2.0 2 0 0 2 2 2 0 DDHD domain DUF913 PF06025.12 EKX72992.1 - 0.076 12.0 4.0 0.21 10.5 4.0 1.8 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) YL1 PF05764.13 EKX72992.1 - 0.1 12.7 17.8 0.26 11.4 17.8 1.6 1 0 0 1 1 1 0 YL1 nuclear protein CobT PF06213.12 EKX72992.1 - 0.16 11.3 23.3 0.28 10.5 23.3 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF4746 PF15928.5 EKX72992.1 - 0.21 11.0 9.3 0.4 10.1 9.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) BUD22 PF09073.10 EKX72992.1 - 0.31 10.3 20.4 0.62 9.3 20.4 1.4 1 0 0 1 1 1 0 BUD22 Zip PF02535.22 EKX72992.1 - 0.32 10.2 2.5 0.54 9.4 2.5 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter XAP5 PF04921.14 EKX72992.1 - 0.47 10.2 9.3 0.98 9.2 9.3 1.5 1 0 0 1 1 1 0 XAP5, circadian clock regulator Na_trans_assoc PF06512.13 EKX72992.1 - 0.48 10.7 13.6 1.4 9.2 13.6 1.8 1 0 0 1 1 1 0 Sodium ion transport-associated RP-C_C PF11800.8 EKX72992.1 - 0.49 10.5 4.6 1.2 9.2 4.6 1.6 1 0 0 1 1 1 0 Replication protein C C-terminal region Roughex PF06020.11 EKX72992.1 - 0.73 8.9 11.1 1.2 8.1 11.1 1.3 1 0 0 1 1 1 0 Drosophila roughex protein CPSF100_C PF13299.6 EKX72992.1 - 0.91 9.7 6.7 2.6 8.2 6.7 1.7 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF5523 PF17661.1 EKX72992.1 - 1.1 8.9 16.8 2 8.1 16.8 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Afi1 PF07792.12 EKX72992.1 - 1.2 9.6 11.7 3.1 8.3 11.7 1.6 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RPN2_C PF18004.1 EKX72992.1 - 5 7.0 14.8 1.7 8.6 11.0 2.2 2 0 0 2 2 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain TFIIA PF03153.13 EKX72992.1 - 8 6.3 18.9 13 5.7 18.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Csm2_III-A PF03750.13 EKX72992.1 - 8.9 7.2 8.1 77 4.2 0.1 4.0 4 0 0 4 4 4 0 Csm2 Type III-A Guanylate_cyc PF00211.20 EKX72993.1 - 1.7e-17 63.7 0.1 1.2e-07 31.6 0.1 3.2 2 1 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain DUF5641 PF18701.1 EKX72993.1 - 0.019 15.1 0.1 0.055 13.6 0.1 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5641) ABC_tran PF00005.27 EKX72994.1 - 4.5e-31 108.2 0.0 3e-17 63.4 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EKX72994.1 - 1.4e-06 28.2 38.9 2e-06 27.7 17.0 3.3 3 0 0 3 3 3 2 ABC transporter transmembrane region AAA_30 PF13604.6 EKX72994.1 - 1.9e-05 24.5 0.1 0.016 14.9 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EKX72994.1 - 6.5e-05 22.6 1.4 0.16 11.8 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EKX72994.1 - 0.00013 22.6 2.3 0.5 10.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EKX72994.1 - 0.00019 21.9 0.0 0.15 12.4 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 EKX72994.1 - 0.00042 20.2 0.8 0.21 11.4 0.5 3.1 2 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EKX72994.1 - 0.00057 19.8 0.3 0.09 12.7 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase Zeta_toxin PF06414.12 EKX72994.1 - 0.00077 18.8 0.3 0.28 10.4 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin DnaB_C PF03796.15 EKX72994.1 - 0.0019 17.6 0.0 0.12 11.7 0.0 2.2 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain Fer4_NifH PF00142.18 EKX72994.1 - 0.0022 17.5 0.1 1.3 8.4 0.0 2.3 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family DUF87 PF01935.17 EKX72994.1 - 0.0047 17.0 1.7 0.19 11.8 0.1 2.7 2 0 0 2 2 2 1 Helicase HerA, central domain SMC_N PF02463.19 EKX72994.1 - 0.005 16.3 0.2 0.2 11.1 0.1 2.5 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain FtsK_SpoIIIE PF01580.18 EKX72994.1 - 0.005 16.2 0.4 1.7 7.9 0.1 2.2 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_18 PF13238.6 EKX72994.1 - 0.007 16.9 0.1 6.8 7.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EKX72994.1 - 0.014 15.5 0.0 0.25 11.4 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase cobW PF02492.19 EKX72994.1 - 0.018 14.6 0.3 6.8 6.2 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 EKX72994.1 - 0.029 14.7 0.1 4.6 7.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 EKX72994.1 - 0.04 14.1 0.0 0.087 13.1 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit NACHT PF05729.12 EKX72994.1 - 0.048 13.6 0.5 3 7.8 0.1 2.5 2 0 0 2 2 2 0 NACHT domain AAA_15 PF13175.6 EKX72994.1 - 0.05 13.3 0.3 5.7 6.5 0.2 2.4 2 0 0 2 2 2 0 AAA ATPase domain NB-ARC PF00931.22 EKX72994.1 - 0.054 12.7 0.7 1.1 8.4 0.1 2.5 2 0 0 2 2 2 0 NB-ARC domain TrwB_AAD_bind PF10412.9 EKX72994.1 - 0.056 12.3 0.2 4.3 6.2 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain ATP_bind_1 PF03029.17 EKX72994.1 - 0.059 13.1 0.2 8 6.2 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MeaB PF03308.16 EKX72994.1 - 0.065 12.2 0.5 0.17 10.9 0.0 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB T2SSE PF00437.20 EKX72994.1 - 0.072 12.1 0.3 6.5 5.7 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_25 PF13481.6 EKX72994.1 - 0.085 12.4 0.1 1.5 8.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 EKX72994.1 - 0.11 12.6 0.1 7.3 6.6 0.0 2.5 2 0 0 2 2 2 0 Dynamin family NTPase_1 PF03266.15 EKX72994.1 - 0.16 11.9 0.3 8.2 6.3 0.1 2.4 2 0 0 2 2 2 0 NTPase TsaE PF02367.17 EKX72994.1 - 0.17 11.9 0.4 3.1 7.8 0.1 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CrgA PF06781.12 EKX72994.1 - 3.8 7.6 6.9 0.68 10.0 0.0 3.1 3 1 0 3 3 2 0 Cell division protein CrgA CKS PF01111.19 EKX72996.1 - 4.4e-17 62.1 0.9 4.4e-17 62.1 0.9 1.8 2 0 0 2 2 2 1 Cyclin-dependent kinase regulatory subunit zf-HIT PF04438.16 EKX72997.1 - 8.8e-09 35.1 11.4 1.9e-08 34.0 11.4 1.6 1 0 0 1 1 1 1 HIT zinc finger Ribosomal_S25 PF03297.15 EKX72997.1 - 0.19 12.0 0.1 0.19 12.0 0.1 2.2 2 1 1 3 3 3 0 S25 ribosomal protein Sec34 PF04136.15 EKX73003.1 - 0.009 15.9 0.2 0.009 15.9 0.2 3.5 4 1 0 4 4 4 2 Sec34-like family APG17 PF04108.12 EKX73003.1 - 0.016 14.3 1.1 0.016 14.3 1.1 2.3 4 0 0 4 4 4 0 Autophagy protein Apg17 CPG4 PF15481.6 EKX73003.1 - 0.017 15.7 0.2 0.087 13.5 0.2 2.2 1 0 0 1 1 1 0 Chondroitin proteoglycan 4 IFT57 PF10498.9 EKX73003.1 - 0.02 13.9 0.5 0.02 13.9 0.5 2.5 3 0 0 3 3 3 0 Intra-flagellar transport protein 57 YgaB PF14182.6 EKX73003.1 - 1.8 9.0 6.3 1.2 9.6 0.2 3.1 3 0 0 3 3 3 0 YgaB-like protein DUF4298 PF14131.6 EKX73003.1 - 2.2 8.3 7.6 7.1 6.7 0.2 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4298) TFIIF_alpha PF05793.12 EKX73005.1 - 1.1 7.7 6.1 1.8 7.1 6.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) ABC_tran PF00005.27 EKX73007.1 - 1.9e-31 109.4 0.0 2.3e-17 63.8 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EKX73007.1 - 5.1e-09 36.2 24.0 5.1e-09 36.2 24.0 3.0 3 0 0 3 3 2 1 ABC transporter transmembrane region AAA_30 PF13604.6 EKX73007.1 - 1.6e-05 24.7 0.0 0.016 15.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EKX73007.1 - 0.00013 22.4 0.0 0.16 12.3 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EKX73007.1 - 0.00016 21.4 3.0 0.15 11.8 0.1 2.9 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EKX73007.1 - 0.00016 22.2 2.3 0.5 10.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EKX73007.1 - 0.00041 20.3 0.3 0.054 13.4 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 EKX73007.1 - 0.00043 20.2 0.2 0.21 11.4 0.1 2.9 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system Zeta_toxin PF06414.12 EKX73007.1 - 0.00057 19.2 0.6 0.27 10.5 0.0 2.8 3 0 0 3 3 2 1 Zeta toxin DnaB_C PF03796.15 EKX73007.1 - 0.0012 18.2 0.0 0.085 12.2 0.0 2.3 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain FtsK_SpoIIIE PF01580.18 EKX73007.1 - 0.0041 16.5 0.4 1.7 7.9 0.1 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family SMC_N PF02463.19 EKX73007.1 - 0.0048 16.4 0.1 0.2 11.1 0.1 2.5 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain DUF87 PF01935.17 EKX73007.1 - 0.0054 16.9 1.7 0.18 11.8 0.1 2.6 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_18 PF13238.6 EKX73007.1 - 0.0089 16.6 0.1 6.6 7.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EKX73007.1 - 0.01 16.1 0.1 5 7.4 0.0 3.1 3 0 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 EKX73007.1 - 0.014 15.5 0.1 0.24 11.5 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase cobW PF02492.19 EKX73007.1 - 0.019 14.5 0.3 6.7 6.3 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 EKX73007.1 - 0.023 14.3 0.0 1.5 8.4 0.0 2.9 3 0 0 3 3 3 0 AAA domain SbcCD_C PF13558.6 EKX73007.1 - 0.038 14.2 0.0 0.087 13.1 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit NACHT PF05729.12 EKX73007.1 - 0.038 13.9 0.5 2.9 7.8 0.1 2.7 2 0 0 2 2 2 0 NACHT domain ATP_bind_1 PF03029.17 EKX73007.1 - 0.042 13.6 2.8 7.9 6.2 0.0 3.4 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_15 PF13175.6 EKX73007.1 - 0.047 13.4 0.5 6 6.5 0.2 2.5 2 0 0 2 2 2 0 AAA ATPase domain NB-ARC PF00931.22 EKX73007.1 - 0.048 12.8 0.7 1 8.5 0.1 2.6 2 0 0 2 2 2 0 NB-ARC domain TrwB_AAD_bind PF10412.9 EKX73007.1 - 0.055 12.4 0.2 4.2 6.2 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain MeaB PF03308.16 EKX73007.1 - 0.057 12.4 0.5 0.17 10.9 0.0 1.9 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB T2SSE PF00437.20 EKX73007.1 - 0.085 11.9 0.5 6.3 5.8 0.1 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein NTPase_1 PF03266.15 EKX73007.1 - 0.11 12.4 0.4 8 6.3 0.1 2.8 2 0 0 2 2 2 0 NTPase Dynamin_N PF00350.23 EKX73007.1 - 0.12 12.4 0.4 8 6.5 0.0 2.6 2 0 0 2 2 2 0 Dynamin family TsaE PF02367.17 EKX73007.1 - 0.16 12.0 0.4 3.1 7.8 0.1 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 EKX73007.1 - 0.19 12.0 0.3 15 5.9 0.0 3.3 3 0 0 3 3 3 0 AAA domain zf-LITAF-like PF10601.9 EKX73007.1 - 5.2 7.4 6.5 65 3.9 0.1 4.1 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain FAINT PF04385.15 EKX73008.1 - 2.5e-15 56.3 4.8 1.6e-07 31.2 0.4 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73009.1 - 1e-09 38.3 1.5 2.7e-09 37.0 1.5 1.8 1 0 0 1 1 1 1 Domain of unknown function, DUF529 Ntox17 PF15524.6 EKX73009.1 - 0.36 11.1 4.5 0.72 10.2 2.2 2.2 1 1 1 2 2 2 0 Novel toxin 17 polyprenyl_synt PF00348.17 EKX73010.1 - 6.3e-51 172.9 0.1 8e-51 172.6 0.1 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase FH2 PF02181.23 EKX73014.1 - 2.4e-43 148.7 4.3 3.7e-43 148.1 4.3 1.2 1 0 0 1 1 1 1 Formin Homology 2 Domain PTEN_C2 PF10409.9 EKX73014.1 - 0.0001 22.1 0.0 0.00038 20.2 0.0 1.9 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein Z1 PF10593.9 EKX73014.1 - 0.084 12.4 0.3 0.33 10.4 0.1 2.0 2 0 0 2 2 2 0 Z1 domain FAINT PF04385.15 EKX73015.1 - 0.026 14.6 0.1 0.22 11.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73016.1 - 3.8e-10 39.7 0.0 6.2e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function, DUF529 MCM PF00493.23 EKX73019.1 - 9e-94 312.7 0.0 1.3e-93 312.2 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EKX73019.1 - 1.8e-19 69.8 0.1 4e-19 68.7 0.1 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EKX73019.1 - 2.5e-18 66.3 0.6 6.1e-18 65.0 0.6 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain AAA_5 PF07728.14 EKX73019.1 - 2e-06 27.8 0.0 5.8e-06 26.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EKX73019.1 - 2.5e-06 27.0 0.6 0.00068 19.1 0.0 2.8 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EKX73019.1 - 2.9e-06 27.2 0.0 3.6e-05 23.6 0.0 2.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF2357 PF09823.9 EKX73019.1 - 0.021 14.1 0.4 0.29 10.4 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF2357) Sigma54_activat PF00158.26 EKX73019.1 - 0.024 14.4 0.0 0.086 12.5 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain SRP14 PF02290.15 EKX73019.1 - 0.054 13.9 0.1 0.12 12.8 0.1 1.5 1 0 0 1 1 1 0 Signal recognition particle 14kD protein AAA_16 PF13191.6 EKX73019.1 - 0.072 13.5 4.7 0.32 11.4 0.2 3.1 2 2 0 3 3 3 0 AAA ATPase domain TF_Zn_Ribbon PF08271.12 EKX73020.1 - 0.11 12.1 0.9 0.23 11.0 0.9 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding DUF900 PF05990.12 EKX73023.1 - 3.8e-22 79.0 0.0 1.9e-21 76.7 0.0 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF900) ANAPC15 PF15243.6 EKX73024.1 - 0.059 13.8 9.5 0.13 12.6 9.5 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 Nucleo_P87 PF07267.11 EKX73024.1 - 3.6 6.3 7.3 4.5 6.0 7.3 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Tubulin PF00091.25 EKX73027.1 - 4.6e-67 226.1 0.1 1.3e-66 224.6 0.0 1.7 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EKX73027.1 - 2.5e-42 144.0 0.2 5.6e-42 142.9 0.2 1.6 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EKX73027.1 - 1.8e-05 25.0 0.0 4.4e-05 23.8 0.0 1.7 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 EKX73027.1 - 0.002 17.4 0.0 0.003 16.8 0.0 1.2 1 0 0 1 1 1 1 Tubulin like Tubulin_3 PF14881.6 EKX73027.1 - 0.12 12.1 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Tubulin domain tRNA-synt_2b PF00587.25 EKX73030.1 - 1.6e-36 126.0 0.0 2.4e-36 125.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EKX73030.1 - 1.1e-13 51.3 4.7 2e-13 50.5 4.7 1.4 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Coatomer_E PF04733.14 EKX73030.1 - 0.064 12.7 0.1 0.16 11.4 0.2 1.6 2 0 0 2 2 2 0 Coatomer epsilon subunit Glyco_transf_88 PF16849.5 EKX73030.1 - 0.066 12.1 0.4 0.11 11.5 0.4 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 88 DUF3807 PF12720.7 EKX73030.1 - 0.18 12.1 3.3 0.34 11.2 3.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) TMF_DNA_bd PF12329.8 EKX73030.1 - 3.4 7.8 10.0 1.4 8.9 1.4 2.5 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Com_YlbF PF06133.11 EKX73030.1 - 9.8 6.8 11.5 1.6 9.3 4.4 2.7 2 1 1 3 3 3 0 Control of competence regulator ComK, YlbF/YmcA FAINT PF04385.15 EKX73031.1 - 7.2e-11 42.0 0.0 9.2e-05 22.4 0.0 2.7 3 0 0 3 3 3 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73032.1 - 1.1e-05 25.4 0.0 1.4e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function, DUF529 AnfO_nitrog PF09582.10 EKX73032.1 - 0.11 11.8 0.1 0.15 11.4 0.1 1.2 1 0 0 1 1 1 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) FAINT PF04385.15 EKX73034.1 - 2.4e-33 114.0 13.7 6.4e-08 32.5 2.6 6.8 6 1 0 6 6 6 6 Domain of unknown function, DUF529 MFS_1 PF07690.16 EKX73035.1 - 1.2e-12 47.5 17.4 1.8e-12 46.8 17.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily RTC PF01137.21 EKX73036.1 - 1.7e-08 33.9 0.0 5.7e-08 32.2 0.0 1.8 1 1 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 EKX73036.1 - 2.7e-08 34.3 0.1 4.4e-08 33.6 0.1 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain DUF5412 PF17428.2 EKX73038.1 - 0.12 12.2 2.8 3.8 7.4 0.0 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5412) FAD_binding_2 PF00890.24 EKX73039.1 - 2.3e-121 405.8 4.0 3.1e-121 405.4 4.0 1.2 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 EKX73039.1 - 9e-46 155.0 0.2 1.3e-45 154.5 0.2 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 EKX73039.1 - 5.8e-06 25.7 1.3 7.7e-05 22.1 0.2 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EKX73039.1 - 1.3e-05 24.5 0.3 0.11 11.7 0.1 3.4 3 1 1 4 4 4 2 Thi4 family GIDA PF01134.22 EKX73039.1 - 0.00064 18.9 0.8 0.0023 17.1 1.1 1.8 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EKX73039.1 - 0.00088 18.6 0.1 0.0014 18.0 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EKX73039.1 - 0.0039 16.8 0.8 0.0093 15.6 0.8 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EKX73039.1 - 0.029 13.1 0.2 0.073 11.8 0.1 1.7 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox_3 PF13738.6 EKX73039.1 - 0.046 13.0 0.2 0.37 10.0 0.3 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EKX73039.1 - 0.074 12.1 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Hydrolase_4 PF12146.8 EKX73040.1 - 2.1e-23 82.8 0.0 2.7e-22 79.2 0.0 2.4 2 1 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX73040.1 - 1.9e-13 50.2 5.2 1.4e-05 25.1 0.1 4.0 3 0 0 3 3 3 3 Domain of unknown function, DUF529 Abhydrolase_6 PF12697.7 EKX73040.1 - 5.2e-05 24.0 0.0 0.00011 22.9 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EKX73040.1 - 0.00036 20.3 0.0 0.0021 17.7 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EKX73040.1 - 0.0054 16.2 0.1 0.67 9.4 0.1 2.3 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 EKX73040.1 - 0.032 14.1 0.0 0.062 13.1 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF1292 PF06949.11 EKX73040.1 - 0.71 10.9 0.0 0.71 10.9 0.0 2.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1292) HutD PF05962.11 EKX73042.1 - 0.033 14.2 0.0 0.04 13.9 0.0 1.2 1 0 0 1 1 1 0 HutD Ribosomal_L27 PF01016.19 EKX73043.1 - 1.5e-21 76.2 0.9 6.2e-17 61.4 0.4 2.9 2 0 0 2 2 2 2 Ribosomal L27 protein Img2 PF05046.14 EKX73044.1 - 0.051 13.9 0.4 3.1 8.2 0.3 2.8 2 1 0 2 2 2 0 Mitochondrial large subunit ribosomal protein (Img2) SAPIS-gp6 PF16722.5 EKX73044.1 - 0.067 13.6 0.6 0.2 12.1 0.6 1.7 1 0 0 1 1 1 0 Pathogenicity island protein gp6 in Staphylococcus Pyr_redox_2 PF07992.14 EKX73045.1 - 6.9e-62 209.3 3.7 1.2e-61 208.6 2.9 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EKX73045.1 - 4.9e-32 110.5 0.1 9e-32 109.6 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EKX73045.1 - 3.7e-20 72.3 9.2 5.6e-17 62.1 0.7 3.7 4 1 1 5 5 4 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EKX73045.1 - 1.1e-10 41.3 3.1 1.2e-09 37.9 3.1 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EKX73045.1 - 2.8e-10 40.1 0.6 1.6e-09 37.6 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 EKX73045.1 - 3e-10 39.7 4.8 2.2e-07 30.3 2.2 2.6 2 1 0 2 2 2 2 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EKX73045.1 - 1.3e-09 38.1 2.1 3e-05 24.2 0.5 2.7 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EKX73045.1 - 2.1e-09 36.6 7.6 0.00012 20.9 0.2 3.9 3 1 1 4 4 4 3 HI0933-like protein FAD_binding_2 PF00890.24 EKX73045.1 - 2.5e-09 36.7 5.3 8.3e-07 28.4 0.8 3.5 3 1 1 4 4 4 2 FAD binding domain AlaDh_PNT_C PF01262.21 EKX73045.1 - 4e-07 29.6 2.0 0.00059 19.2 0.1 2.6 3 0 0 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 EKX73045.1 - 1.1e-06 28.1 0.2 0.0003 20.1 0.0 2.9 3 0 0 3 3 3 1 Thi4 family DAO PF01266.24 EKX73045.1 - 6.5e-05 22.7 11.1 0.004 16.8 0.6 3.8 3 1 1 4 4 4 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EKX73045.1 - 0.00026 20.2 2.7 0.12 11.4 0.2 2.4 2 0 0 2 2 2 2 Lycopene cyclase protein FAD_binding_3 PF01494.19 EKX73045.1 - 0.00095 18.5 5.4 0.021 14.1 0.4 2.4 2 1 0 2 2 2 2 FAD binding domain 3HCDH_N PF02737.18 EKX73045.1 - 0.0021 18.0 2.3 0.018 14.9 0.1 2.4 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 EKX73045.1 - 0.0045 17.4 2.6 0.28 11.7 0.1 3.0 3 1 0 3 3 3 1 Putative NAD(P)-binding K_oxygenase PF13434.6 EKX73045.1 - 0.0089 15.2 0.1 0.7 9.0 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) XdhC_C PF13478.6 EKX73045.1 - 0.011 16.3 0.0 6.2 7.3 0.0 2.4 2 0 0 2 2 2 0 XdhC Rossmann domain 2-Hacid_dh_C PF02826.19 EKX73045.1 - 0.065 12.6 0.0 2.2 7.6 0.0 2.5 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 EKX73045.1 - 0.45 10.5 1.5 2.8 7.9 0.0 2.6 3 0 0 3 3 3 0 FAD-NAD(P)-binding FAINT PF04385.15 EKX73047.1 - 4e-08 33.2 12.0 6.6e-05 22.9 0.3 3.0 4 1 0 4 4 4 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73048.1 - 6.9e-13 48.5 0.0 0.00022 21.2 0.0 3.4 3 0 0 3 3 3 3 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73049.1 - 7.7e-54 179.7 31.4 1.1e-06 28.6 0.1 11.6 11 0 0 11 11 11 11 Domain of unknown function, DUF529 HR1 PF02185.16 EKX73049.1 - 0.36 11.0 9.0 1.6 8.9 0.5 3.3 3 1 1 4 4 4 0 Hr1 repeat PspA_IM30 PF04012.12 EKX73049.1 - 0.55 9.8 9.2 0.059 12.9 3.9 2.1 2 0 0 2 2 2 0 PspA/IM30 family FAINT PF04385.15 EKX73054.1 - 1.6e-26 92.2 0.4 3.1e-09 36.8 0.0 5.4 5 0 0 5 5 5 4 Domain of unknown function, DUF529 EMA PF02488.15 EKX73054.1 - 0.0022 17.7 4.3 0.22 11.2 0.3 2.5 2 0 0 2 2 2 2 Merozoite Antigen TypeIII_RM_meth PF12564.8 EKX73054.1 - 0.14 12.3 0.7 4.6 7.4 0.9 2.5 2 0 0 2 2 2 0 Type III restriction/modification enzyme methylation subunit Neur_chan_memb PF02932.16 EKX73054.1 - 0.25 11.4 1.0 0.52 10.3 1.0 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RRM_1 PF00076.22 EKX73055.1 - 2e-20 72.3 0.0 2.9e-20 71.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EKX73055.1 - 3.6e-05 23.6 0.0 5.5e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_5 PF13893.6 EKX73055.1 - 6.7e-05 22.5 0.0 0.0001 21.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3892 PF13031.6 EKX73056.1 - 0.05 14.2 0.1 0.22 12.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3892) Skp1 PF01466.19 EKX73059.1 - 1.1e-19 70.2 0.1 1.8e-19 69.6 0.1 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 EKX73059.1 - 2.6e-17 62.7 1.1 5.7e-17 61.6 1.1 1.6 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain SCAN PF02023.17 EKX73059.1 - 0.06 13.2 0.1 0.13 12.1 0.1 1.6 1 1 0 1 1 1 0 SCAN domain Myb_DNA-binding PF00249.31 EKX73059.1 - 0.18 12.0 0.3 11 6.3 0.0 3.1 3 0 0 3 3 3 0 Myb-like DNA-binding domain Hum_adeno_E3A PF05393.11 EKX73060.1 - 0.21 11.6 2.4 0.4 10.7 2.4 1.4 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein Peptidase_M17 PF00883.21 EKX73061.1 - 5.2e-68 229.6 2.0 8.9e-68 228.8 2.0 1.2 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain AHD PF17793.1 EKX73061.1 - 0.037 13.8 0.1 0.31 10.9 0.0 2.6 3 0 0 3 3 3 0 ANC1 homology domain (AHD) GH43_C PF16369.5 EKX73062.1 - 0.069 13.8 1.2 0.69 10.6 0.1 3.2 3 0 0 3 3 3 0 C-terminal lipocalin-like domain Prefoldin_2 PF01920.20 EKX73064.1 - 1.1e-07 31.8 8.4 1.1e-07 31.8 8.4 1.7 1 1 1 2 2 2 1 Prefoldin subunit FlxA PF14282.6 EKX73064.1 - 0.11 12.5 7.7 0.21 11.6 3.9 2.2 2 0 0 2 2 2 0 FlxA-like protein Seryl_tRNA_N PF02403.22 EKX73064.1 - 0.53 10.5 8.2 13 6.0 0.3 2.1 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Ribosomal_L24e PF01246.20 EKX73066.1 - 3.4e-32 110.5 3.0 7.9e-32 109.3 3.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L24e zf-FCS PF06467.14 EKX73066.1 - 0.045 13.7 2.8 0.092 12.7 2.8 1.6 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif SYF2 PF08231.12 EKX73067.1 - 5.5e-32 111.4 13.0 5.5e-32 111.4 13.0 3.0 2 1 0 2 2 2 1 SYF2 splicing factor Pro_isomerase PF00160.21 EKX73067.1 - 7.4e-21 75.1 0.7 6.5e-18 65.5 0.7 2.6 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD MctB PF11382.8 EKX73067.1 - 0.35 10.5 2.6 0.73 9.5 2.6 1.5 1 0 0 1 1 1 0 Copper transport outer membrane protein, MctB MTBP_N PF14918.6 EKX73067.1 - 4.4 6.7 8.8 1.3 8.4 5.5 1.7 2 0 0 2 2 2 0 MDM2-binding FAINT PF04385.15 EKX73069.1 - 0.004 17.2 0.1 0.0062 16.6 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73070.1 - 3.5e-09 36.6 0.0 0.00091 19.2 0.0 3.2 3 0 0 3 3 3 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73071.1 - 2.8e-10 40.1 15.8 0.0033 17.5 0.1 5.0 4 1 1 5 5 5 4 Domain of unknown function, DUF529 ABC_tran PF00005.27 EKX73072.1 - 4.6e-31 108.1 0.0 4.2e-17 62.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EKX73072.1 - 1.2e-06 28.6 2.6 0.1 12.3 0.0 4.1 4 0 0 4 4 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EKX73072.1 - 2.2e-05 24.1 0.9 0.065 13.0 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EKX73072.1 - 3.7e-05 24.2 0.0 0.04 14.3 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 EKX73072.1 - 7e-05 23.4 3.3 0.16 12.5 0.1 2.6 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EKX73072.1 - 8e-05 22.4 0.1 0.066 12.9 0.0 2.2 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EKX73072.1 - 0.00021 21.3 1.0 0.019 14.9 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase DnaB_C PF03796.15 EKX73072.1 - 0.00025 20.5 0.0 0.014 14.8 0.0 2.2 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain Zeta_toxin PF06414.12 EKX73072.1 - 0.0014 18.0 0.3 0.54 9.5 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_18 PF13238.6 EKX73072.1 - 0.0027 18.3 0.1 2.5 8.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 EKX73072.1 - 0.0041 17.2 3.0 0.067 13.3 0.1 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain MMR_HSR1 PF01926.23 EKX73072.1 - 0.0049 16.9 0.3 0.1 12.7 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EKX73072.1 - 0.0082 16.4 0.1 1.2 9.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 EKX73072.1 - 0.009 15.4 0.4 1.7 7.9 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family SMC_N PF02463.19 EKX73072.1 - 0.0094 15.4 1.4 0.21 11.0 0.2 2.7 2 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain NACHT PF05729.12 EKX73072.1 - 0.011 15.7 1.0 3 7.8 0.2 2.8 2 0 0 2 2 2 0 NACHT domain AAA_15 PF13175.6 EKX73072.1 - 0.016 15.0 1.3 4.6 6.8 0.1 2.4 2 0 0 2 2 2 0 AAA ATPase domain cobW PF02492.19 EKX73072.1 - 0.021 14.4 0.5 6.8 6.2 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.17 EKX73072.1 - 0.03 14.1 0.1 11 5.7 0.1 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MeaB PF03308.16 EKX73072.1 - 0.033 13.2 0.5 0.081 11.9 0.0 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_25 PF13481.6 EKX73072.1 - 0.078 12.6 0.2 1.5 8.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EKX73072.1 - 0.084 12.0 0.7 1.2 8.3 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain ATPase_2 PF01637.18 EKX73072.1 - 0.09 12.7 1.6 14 5.5 0.0 3.3 4 0 0 4 4 4 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 EKX73072.1 - 0.092 12.5 0.1 4.8 6.9 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein NTPase_1 PF03266.15 EKX73072.1 - 0.12 12.2 0.5 8.4 6.3 0.2 2.4 2 0 0 2 2 2 0 NTPase TsaE PF02367.17 EKX73072.1 - 0.13 12.3 0.4 3.1 7.8 0.2 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TrwB_AAD_bind PF10412.9 EKX73072.1 - 0.14 11.0 0.5 4.5 6.1 0.1 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain SbcCD_C PF13558.6 EKX73072.1 - 0.15 12.3 0.0 0.34 11.2 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit T2SSE PF00437.20 EKX73072.1 - 0.16 11.0 1.7 6.9 5.6 0.2 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein Dynamin_N PF00350.23 EKX73072.1 - 0.2 11.7 1.1 5.8 6.9 0.1 2.5 2 0 0 2 2 2 0 Dynamin family FAINT PF04385.15 EKX73075.1 - 0.00076 19.5 0.0 0.0017 18.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73077.1 - 1.5e-23 82.6 0.2 1.4e-05 25.1 0.0 4.8 4 1 1 5 5 5 4 Domain of unknown function, DUF529 B_lectin PF01453.24 EKX73077.1 - 0.14 12.7 0.0 26 5.4 0.0 2.7 2 0 0 2 2 2 0 D-mannose binding lectin RNase_PH PF01138.21 EKX73083.1 - 1.6e-19 70.7 0.0 2.3e-19 70.2 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EKX73083.1 - 0.0019 18.2 0.0 0.0035 17.4 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Aldo_ket_red PF00248.21 EKX73084.1 - 1.6e-66 224.5 0.0 2.6e-66 223.8 0.0 1.3 1 0 0 1 1 1 1 Aldo/keto reductase family DUF1463 PF07316.11 EKX73085.1 - 0.043 13.7 3.4 0.12 12.2 0.1 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1463) DUF2140 PF09911.9 EKX73085.1 - 0.28 10.7 1.4 0.44 10.1 0.4 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) DUF1211 PF06736.11 EKX73086.1 - 0.19 12.2 8.2 0.74 10.3 2.0 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1211) NIF PF03031.18 EKX73087.1 - 1.7e-22 79.9 0.6 3.2e-22 79.0 0.6 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Metallophos PF00149.28 EKX73088.1 - 1.9e-31 110.2 0.5 6.4e-31 108.4 0.2 1.9 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 EKX73088.1 - 2.9e-20 72.4 0.1 4.4e-19 68.6 0.0 2.3 2 0 0 2 2 2 1 PPP5 TPR repeat region TPR_1 PF00515.28 EKX73088.1 - 1.5e-12 46.8 3.0 0.00059 19.6 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EKX73088.1 - 6e-12 44.7 0.8 0.00093 19.1 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EKX73088.1 - 2.1e-05 24.1 0.1 0.034 13.8 0.0 2.6 2 0 0 2 2 2 2 TPR repeat TPR_8 PF13181.6 EKX73088.1 - 0.0045 17.1 1.5 5.7 7.4 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EKX73088.1 - 0.19 11.9 0.1 7.4 6.9 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 EKX73088.1 - 0.32 10.5 1.3 15 5.1 0.0 3.0 4 0 0 4 4 4 0 SHNi-TPR Phosducin PF02114.16 EKX73089.1 - 3.8e-06 26.0 0.2 4.2e-06 25.9 0.2 1.1 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 EKX73089.1 - 1.9e-05 24.6 0.0 3.2e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Ran_BP1 PF00638.18 EKX73091.1 - 0.00015 22.0 0.0 0.00026 21.3 0.0 1.4 1 0 0 1 1 1 1 RanBP1 domain Presenilin PF01080.17 EKX73091.1 - 6.6 5.4 5.9 7.7 5.2 5.9 1.2 1 0 0 1 1 1 0 Presenilin Ribosomal_S8e PF01201.22 EKX73092.1 - 1.2e-55 187.4 0.0 1.5e-55 187.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e DUF3638 PF12340.8 EKX73094.1 - 7.8e-23 81.0 0.1 2e-20 73.1 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF3638) DUF3645 PF12359.8 EKX73094.1 - 5.5e-13 48.1 0.0 1.2e-12 47.0 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) Vps62 PF06101.11 EKX73094.1 - 4e-05 22.1 0.0 6.8e-05 21.4 0.0 1.2 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 EF-hand_7 PF13499.6 EKX73094.1 - 0.021 15.2 0.0 0.095 13.2 0.0 2.1 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_8 PF13833.6 EKX73094.1 - 0.051 13.4 0.1 0.47 10.3 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.32 EKX73094.1 - 0.059 13.0 0.2 0.22 11.2 0.2 2.0 1 0 0 1 1 1 0 EF hand Cpn60_TCP1 PF00118.24 EKX73095.1 - 1.1e-164 548.7 0.2 1.2e-164 548.6 0.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family ATP12 PF07542.11 EKX73096.1 - 2.9e-13 50.0 0.0 4.4e-13 49.4 0.0 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein SIS PF01380.22 EKX73097.1 - 9.6e-32 109.6 0.1 7.2e-15 55.0 0.0 2.5 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 EKX73097.1 - 1.2e-12 48.2 0.0 1.9e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EKX73097.1 - 0.0014 18.6 0.0 0.0034 17.3 0.0 1.7 1 1 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 EKX73097.1 - 0.053 12.4 0.1 0.11 11.4 0.1 1.4 1 0 0 1 1 1 0 Glutamine amidotransferases class-II EF-hand_4 PF12763.7 EKX73098.1 - 8.6e-22 77.1 0.4 1.2e-10 41.2 0.0 3.8 4 0 0 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EKX73098.1 - 1.1e-07 30.9 0.3 0.0087 15.6 0.0 3.8 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 EKX73098.1 - 1.6e-07 31.7 7.2 1.1e-05 25.8 1.8 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EKX73098.1 - 5.3e-06 25.7 0.3 0.17 11.4 0.0 3.2 2 1 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EKX73098.1 - 0.00012 21.7 0.7 0.38 10.8 0.0 4.0 4 0 0 4 4 4 1 EF-hand domain EF-hand_8 PF13833.6 EKX73098.1 - 0.011 15.6 4.7 0.1 12.5 0.1 3.4 2 1 1 3 3 3 0 EF-hand domain pair Tup_N PF08581.10 EKX73098.1 - 0.042 14.1 1.2 0.042 14.1 1.2 3.5 3 1 0 4 4 4 0 Tup N-terminal DHR10 PF18595.1 EKX73098.1 - 2.4 8.2 27.3 1.4 9.0 5.4 2.4 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain DUF4615 PF15393.6 EKX73098.1 - 2.9 8.5 13.0 66 4.1 13.0 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4615) TPR_MLP1_2 PF07926.12 EKX73098.1 - 3.7 7.6 22.5 5.5 7.1 12.4 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein RRM_1 PF00076.22 EKX73099.1 - 2.5e-43 145.8 2.6 1e-16 60.5 0.1 5.8 5 1 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EKX73099.1 - 2.5e-05 23.9 0.2 0.0062 16.1 0.0 3.6 4 0 0 4 4 4 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EKX73099.1 - 5.7e-05 22.9 0.2 3.9 7.4 0.0 4.9 5 0 0 5 5 5 1 Occluded RNA-recognition motif Phage_TAC_13 PF16459.5 EKX73099.1 - 7.4e-05 23.1 0.1 0.32 11.5 0.0 2.9 2 0 0 2 2 2 2 Phage tail assembly chaperone, TAC RRM_7 PF16367.5 EKX73099.1 - 0.00075 19.6 0.3 2.6 8.2 0.0 3.4 2 2 0 2 2 2 2 RNA recognition motif RRM_Rrp7 PF17799.1 EKX73099.1 - 0.001 18.9 3.1 1 9.1 0.0 3.7 3 0 0 3 3 3 2 Rrp7 RRM-like N-terminal domain TRAP_alpha PF03896.16 EKX73099.1 - 0.9 8.7 6.1 3.2 6.9 6.1 1.9 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Cgr1 PF03879.14 EKX73101.1 - 7.9e-08 32.6 23.8 9.4e-08 32.4 23.8 1.1 1 0 0 1 1 1 1 Cgr1 family Reoviridae_Vp9 PF08978.10 EKX73101.1 - 0.15 11.2 3.2 0.18 11.0 3.2 1.1 1 0 0 1 1 1 0 Reoviridae VP9 FTCD_C PF04961.12 EKX73101.1 - 0.16 11.7 6.9 0.21 11.4 6.9 1.1 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase DUF2833 PF11090.8 EKX73101.1 - 0.38 11.2 2.9 2.1 8.8 0.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2833) AAA_11 PF13086.6 EKX73101.1 - 1.3 8.8 9.8 1.6 8.5 9.8 1.1 1 0 0 1 1 1 0 AAA domain YabA PF06156.13 EKX73101.1 - 4.1 8.1 8.5 7.2 7.3 8.5 1.5 1 1 0 1 1 1 0 Initiation control protein YabA EMC3_TMCO1 PF01956.16 EKX73101.1 - 6 6.6 12.9 11 5.7 12.9 1.4 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Atg14 PF10186.9 EKX73101.1 - 8 5.4 13.6 8.8 5.3 13.6 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DER1 PF04511.15 EKX73103.1 - 4.5e-13 49.5 14.5 7.3e-13 48.9 14.5 1.3 1 0 0 1 1 1 1 Der1-like family TPD52 PF04201.15 EKX73103.1 - 0.19 11.3 0.1 0.31 10.7 0.1 1.2 1 0 0 1 1 1 0 Tumour protein D52 family FAST_1 PF06743.15 EKX73104.1 - 0.00084 19.2 1.7 0.0021 18.0 0.0 2.6 3 0 0 3 3 3 1 FAST kinase-like protein, subdomain 1 FAINT PF04385.15 EKX73105.1 - 3.2e-34 116.8 9.3 5.9e-09 35.9 0.4 7.2 6 1 0 6 6 6 6 Domain of unknown function, DUF529 DUF1180 PF06679.12 EKX73105.1 - 0.31 11.5 1.5 0.66 10.4 1.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) PEP-utilisers_N PF05524.13 EKX73106.1 - 0.015 15.5 0.1 4.5 7.5 0.0 2.6 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal IN_DBD_C PF00552.21 EKX73106.1 - 0.07 12.4 0.2 0.12 11.6 0.2 1.3 1 0 0 1 1 1 0 Integrase DNA binding domain BCNT PF07572.12 EKX73109.1 - 1.2e-13 50.9 3.1 1.2e-13 50.9 3.1 2.4 3 0 0 3 3 3 1 Bucentaur or craniofacial development Pex24p PF06398.11 EKX73110.1 - 0.22 10.5 7.7 0.63 9.0 7.7 1.7 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Polyketide_cyc PF03364.20 EKX73112.1 - 4.4e-13 49.6 0.0 5.4e-13 49.3 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport DEAD PF00270.29 EKX73113.1 - 1.1e-45 155.5 0.0 9.3e-45 152.5 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKX73113.1 - 2.7e-28 98.5 0.0 1.8e-27 95.8 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKX73113.1 - 4.2e-05 23.6 0.0 7.5e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EKX73113.1 - 0.0094 15.3 0.0 0.023 14.0 0.0 1.6 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit Spt5-NGN PF03439.13 EKX73114.1 - 2.8e-22 78.4 0.0 6.2e-22 77.3 0.0 1.7 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.29 EKX73114.1 - 1.5e-10 40.6 20.1 0.00086 19.2 0.3 7.9 8 0 0 8 8 8 3 KOW motif Spt5_N PF11942.8 EKX73114.1 - 0.0003 21.7 10.6 0.00064 20.7 10.6 1.6 1 0 0 1 1 1 1 Spt5 transcription elongation factor, acidic N-terminal YajC PF02699.15 EKX73114.1 - 2.3 8.2 11.2 30 4.6 0.5 5.1 4 1 1 5 5 5 0 Preprotein translocase subunit NIF PF03031.18 EKX73116.1 - 4.8e-22 78.4 3.8 7.3e-22 77.8 0.7 2.5 2 1 0 2 2 2 1 NLI interacting factor-like phosphatase DUF1635 PF07795.11 EKX73116.1 - 0.022 14.7 0.3 0.07 13.0 0.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1635) AP2 PF00847.20 EKX73117.1 - 7.7e-06 26.0 0.7 1.4e-05 25.2 0.7 1.4 1 0 0 1 1 1 1 AP2 domain SAP18 PF06487.12 EKX73118.1 - 1.5e-08 34.9 0.2 1.5e-08 34.9 0.2 3.8 3 2 0 3 3 3 1 Sin3 associated polypeptide p18 (SAP18) Sld5 PF05916.11 EKX73119.1 - 1.4e-16 60.9 0.1 3.7e-13 49.9 0.0 2.5 2 0 0 2 2 2 2 GINS complex protein Ribosomal_S8e PF01201.22 EKX73120.1 - 2.3e-48 163.8 3.8 3.5e-48 163.3 3.8 1.3 1 0 0 1 1 1 1 Ribosomal protein S8e PRK PF00485.18 EKX73120.1 - 0.086 12.6 0.1 8.7 6.0 0.0 2.2 1 1 1 2 2 2 0 Phosphoribulokinase / Uridine kinase family DUF3364 PF11844.8 EKX73120.1 - 4.7 7.5 6.6 0.58 10.4 1.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3364) DUF1604 PF07713.13 EKX73121.1 - 5.9e-11 42.0 0.0 1.9e-10 40.4 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1604) DUF1754 PF08555.10 EKX73122.1 - 7.3e-14 52.4 1.3 1.2e-13 51.6 1.3 1.3 1 0 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) TCTP PF00838.17 EKX73122.1 - 0.01 16.2 2.7 0.012 16.0 2.7 1.1 1 0 0 1 1 1 0 Translationally controlled tumour protein DUF2514 PF10721.9 EKX73122.1 - 0.084 12.9 0.1 0.11 12.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) DUF1542 PF07564.11 EKX73122.1 - 3.2 7.9 8.8 0.25 11.5 4.0 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) GTP_EFTU PF00009.27 EKX73124.1 - 2.8e-61 206.5 0.0 4.5e-61 205.8 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EKX73124.1 - 8.1e-32 109.5 0.0 1.8e-31 108.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 EKX73124.1 - 7.8e-29 99.6 0.0 1.6e-28 98.5 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EKX73124.1 - 4.8e-25 87.4 0.0 1.2e-24 86.2 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EKX73124.1 - 1.2e-10 41.6 0.0 3.1e-10 40.3 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EKX73124.1 - 0.002 18.2 0.0 0.0038 17.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RF3_C PF16658.5 EKX73124.1 - 0.0023 17.8 0.0 0.0056 16.5 0.0 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain BDV_M PF16520.5 EKX73124.1 - 0.15 12.4 0.0 0.34 11.3 0.0 1.6 1 0 0 1 1 1 0 ssRNA-binding matrix protein of Bornaviridae FAINT PF04385.15 EKX73126.1 - 1.8e-07 31.1 2.7 0.0023 18.0 0.8 3.0 2 1 0 2 2 2 2 Domain of unknown function, DUF529 MACPF PF01823.19 EKX73130.1 - 1.2e-26 94.1 3.8 2.6e-25 89.8 3.8 2.2 1 1 0 1 1 1 1 MAC/Perforin domain PRC2_HTH_1 PF18118.1 EKX73130.1 - 0.00066 20.4 0.2 0.0014 19.4 0.2 1.5 1 0 0 1 1 1 1 Polycomb repressive complex 2 tri-helical domain GAGBD PF16828.5 EKX73130.1 - 0.05 13.7 0.7 0.097 12.8 0.7 1.4 1 0 0 1 1 1 0 GAG-binding domain on surface antigen PspB PF06667.12 EKX73130.1 - 0.21 11.7 0.1 0.41 10.7 0.1 1.3 1 0 0 1 1 1 0 Phage shock protein B Proteasome PF00227.26 EKX73131.1 - 5.2e-58 195.7 0.0 7.6e-58 195.1 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EKX73131.1 - 7.1e-10 38.4 0.8 1.6e-09 37.3 0.0 2.0 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Bac_surface_Ag PF01103.23 EKX73132.1 - 3.4e-23 82.7 7.8 4.7e-23 82.2 7.8 1.1 1 0 0 1 1 1 1 Surface antigen CPW_WPC PF09717.10 EKX73133.1 - 9.9e-58 193.0 50.3 5.8e-14 52.8 5.0 5.6 5 1 0 5 5 5 5 Plasmodium falciparum domain of unknown function (CPW_WPC) FOG_N PF15888.5 EKX73133.1 - 0.027 14.8 3.5 2.5 8.5 0.4 2.5 2 0 0 2 2 2 0 Folded gastrulation N-terminus Defensin_1 PF00323.19 EKX73133.1 - 0.12 12.9 1.4 3.8 8.2 0.1 3.1 2 0 0 2 2 2 0 Mammalian defensin 1-cysPrx_C PF10417.9 EKX73133.1 - 0.2 11.5 2.9 5.9 6.8 0.1 3.5 3 0 0 3 3 3 0 C-terminal domain of 1-Cys peroxiredoxin Peptidase_S24 PF00717.23 EKX73134.1 - 4.6e-12 45.7 0.1 7.8e-12 45.0 0.1 1.4 1 0 0 1 1 1 1 Peptidase S24-like M11L PF11099.8 EKX73135.1 - 0.01 16.1 0.0 0.014 15.6 0.0 1.3 1 0 0 1 1 1 0 Apoptosis regulator M11L like UbiA PF01040.18 EKX73136.1 - 3.7e-44 150.9 6.6 4.8e-44 150.6 6.6 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family BTP PF05232.12 EKX73136.1 - 0.036 14.1 0.7 0.14 12.3 0.7 2.0 1 0 0 1 1 1 0 Chlorhexidine efflux transporter MACPF PF01823.19 EKX73137.1 - 4.4e-43 147.8 2.3 5.5e-43 147.5 2.3 1.1 1 0 0 1 1 1 1 MAC/Perforin domain XTBD PF11952.8 EKX73137.1 - 0.086 12.6 0.0 0.98 9.2 0.0 2.3 2 0 0 2 2 2 0 XRN-Two Binding Domain, XTBD MACPF PF01823.19 EKX73138.1 - 1.7e-61 208.0 13.6 7.1e-33 114.5 4.3 2.5 2 1 0 2 2 2 2 MAC/Perforin domain TGF_beta_GS PF08515.12 EKX73138.1 - 0.046 13.2 0.2 0.11 12.1 0.2 1.7 1 0 0 1 1 1 0 Transforming growth factor beta type I GS-motif OHA PF14418.6 EKX73139.1 - 2.1e-23 81.9 0.0 4.6e-23 80.8 0.0 1.6 1 0 0 1 1 1 1 OST-HTH Associated domain OST-HTH PF12872.7 EKX73139.1 - 0.00037 20.3 0.1 0.0014 18.4 0.1 2.0 1 0 0 1 1 1 1 OST-HTH/LOTUS domain GTP1_OBG PF01018.22 EKX73140.1 - 5.1e-29 100.9 1.1 6.7e-29 100.5 1.1 1.1 1 0 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.23 EKX73140.1 - 1.2e-20 73.7 0.0 1.9e-20 73.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EKX73140.1 - 1.2e-14 54.1 0.0 1.9e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.21 EKX73140.1 - 7.4e-05 22.3 0.0 0.00011 21.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKX73140.1 - 0.00023 20.7 0.0 0.026 14.1 0.0 2.3 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EKX73140.1 - 0.00064 19.2 0.0 0.00098 18.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit NOG1 PF06858.14 EKX73140.1 - 0.026 14.3 0.0 0.062 13.1 0.0 1.6 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) MeaB PF03308.16 EKX73140.1 - 0.17 10.8 0.0 1 8.3 0.0 1.9 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB dCMP_cyt_deam_1 PF00383.23 EKX73142.1 - 7.5e-15 54.6 0.5 9.9e-15 54.3 0.5 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EKX73142.1 - 1.4e-14 54.0 0.6 1.5e-13 50.6 0.6 2.0 1 1 0 1 1 1 1 MafB19-like deaminase gag_pre-integrs PF13976.6 EKX73142.1 - 0.083 12.8 0.9 0.16 11.9 0.9 1.4 1 0 0 1 1 1 0 GAG-pre-integrase domain Bd3614-deam PF14439.6 EKX73142.1 - 0.088 12.9 0.4 0.14 12.2 0.4 1.4 1 0 0 1 1 1 0 Bd3614-like deaminase SPC25 PF06703.11 EKX73143.1 - 2.9e-08 33.7 1.1 4.1e-08 33.2 1.1 1.2 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) Methyltransf_3 PF01596.17 EKX73143.1 - 0.094 11.9 0.1 0.19 10.9 0.1 1.4 1 0 0 1 1 1 0 O-methyltransferase Snf7 PF03357.21 EKX73144.1 - 1.9e-15 56.9 3.6 2.5e-15 56.5 3.6 1.1 1 0 0 1 1 1 1 Snf7 Lipoprotein_3 PF00938.17 EKX73144.1 - 0.13 12.4 0.2 0.66 10.2 0.0 2.1 2 0 0 2 2 2 0 Lipoprotein DEAD PF00270.29 EKX73145.1 - 8.3e-32 110.4 0.0 2.8e-31 108.7 0.0 2.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKX73145.1 - 3.8e-19 69.1 0.4 1.1e-17 64.4 0.0 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKX73145.1 - 3.7e-07 30.3 0.5 1.9e-06 28.0 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 EKX73145.1 - 5.7e-06 25.3 0.0 1.3e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain POP1 PF06978.11 EKX73146.1 - 3.7e-35 121.8 20.9 2.3e-18 67.0 8.2 2.3 1 1 1 2 2 2 2 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 EKX73146.1 - 2.3e-19 69.5 0.1 7e-19 68.0 0.0 1.9 2 0 0 2 2 2 1 POPLD (NUC188) domain Hist_deacetyl PF00850.19 EKX73147.1 - 4.9e-95 318.5 0.0 6.6e-95 318.1 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain IPK PF03770.16 EKX73147.1 - 9.6e-39 133.3 0.4 1.8e-38 132.4 0.4 1.5 1 0 0 1 1 1 1 Inositol polyphosphate kinase Gal_Lectin PF02140.18 EKX73147.1 - 0.032 14.7 0.2 0.087 13.3 0.2 1.7 1 0 0 1 1 1 0 Galactose binding lectin domain eIF-3_zeta PF05091.12 EKX73148.1 - 7.5e-158 526.7 10.1 8.9e-158 526.5 10.1 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Patatin PF01734.22 EKX73149.1 - 8.2e-30 104.5 0.0 1.7e-29 103.5 0.0 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase zf-HC5HC2H_2 PF13832.6 EKX73150.1 - 5.8e-16 58.6 23.8 7.5e-10 38.9 6.7 5.7 7 0 0 7 7 7 2 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EKX73150.1 - 6.9e-13 48.7 19.1 3.6e-08 33.5 4.9 6.4 5 1 1 6 6 6 3 PHD-like zinc-binding domain PHD PF00628.29 EKX73150.1 - 0.00012 21.9 31.2 0.00014 21.7 10.5 8.4 8 2 1 9 9 9 3 PHD-finger P4Ha_N PF08336.11 EKX73150.1 - 0.11 12.5 1.8 0.63 10.1 0.2 2.4 2 0 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Rhomboid PF01694.22 EKX73151.1 - 1.1e-24 87.1 5.4 4.8e-22 78.6 5.4 2.5 1 1 0 1 1 1 1 Rhomboid family Urb2 PF10441.9 EKX73151.1 - 0.43 10.5 3.6 7.3 6.5 0.1 3.1 3 1 1 4 4 4 0 Urb2/Npa2 family Ribosomal_L15e PF00827.17 EKX73153.1 - 1.2e-89 299.2 7.7 1.3e-89 299.0 7.7 1.0 1 0 0 1 1 1 1 Ribosomal L15 Clat_adaptor_s PF01217.20 EKX73154.1 - 6.3e-16 58.6 0.5 8.3e-16 58.2 0.5 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain AP2 PF00847.20 EKX73155.1 - 8e-15 54.8 0.6 1.6e-14 53.8 0.6 1.6 1 0 0 1 1 1 1 AP2 domain Mqo PF06039.15 EKX73156.1 - 3.4e-18 65.5 0.0 7.6e-18 64.3 0.0 1.5 1 1 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) DAO PF01266.24 EKX73156.1 - 3.8e-13 49.8 0.0 6.1e-13 49.1 0.0 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EKX73156.1 - 8.8e-05 21.9 0.0 0.0026 17.1 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EKX73156.1 - 0.038 14.0 0.0 8.6 6.3 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EKX73156.1 - 0.082 12.1 0.0 1 8.5 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EKX73156.1 - 0.1 12.8 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain GCFC PF07842.12 EKX73157.1 - 0.0068 16.0 0.2 0.084 12.5 0.1 2.3 1 1 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein YGGT PF02325.17 EKX73158.1 - 0.28 11.7 0.9 11 6.6 0.5 2.4 1 1 1 2 2 2 0 YGGT family SWIB PF02201.18 EKX73159.1 - 8.6e-06 25.5 0.3 3.9e-05 23.4 0.0 2.3 2 0 0 2 2 2 1 SWIB/MDM2 domain Y_Y_Y PF07495.13 EKX73159.1 - 0.048 13.6 1.6 0.24 11.4 0.5 2.5 2 0 0 2 2 2 0 Y_Y_Y domain SMP_2 PF10144.9 EKX73160.1 - 0.061 13.0 0.4 0.17 11.5 0.4 1.7 1 0 0 1 1 1 0 Bacterial virulence factor haemolysin NRN1 PF15056.6 EKX73160.1 - 0.1 12.7 0.2 2.3 8.3 0.2 2.9 2 0 0 2 2 2 0 Neuritin protein family DUF4539 PF15072.6 EKX73161.1 - 2.9e-18 65.7 0.0 3.9e-18 65.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4539) Zip PF02535.22 EKX73162.1 - 2.1e-25 89.6 7.1 2.1e-25 89.6 7.1 1.7 2 1 0 2 2 2 1 ZIP Zinc transporter MgtC PF02308.16 EKX73162.1 - 0.081 13.3 9.7 1.9 8.9 9.7 2.3 1 1 0 1 1 1 0 MgtC family NUDIX PF00293.28 EKX73163.1 - 2.2e-08 34.2 0.0 3e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain FAINT PF04385.15 EKX73168.1 - 3.5e-14 52.6 12.1 2.2e-08 34.0 0.4 2.5 2 0 0 2 2 2 2 Domain of unknown function, DUF529 ETRAMP PF09716.10 EKX73168.1 - 0.047 13.7 5.5 0.098 12.7 0.1 2.6 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) CPBP PF02517.16 EKX73169.1 - 1.2e-12 48.0 2.8 1.2e-12 48.0 2.8 2.7 3 1 0 3 3 3 1 CPBP intramembrane metalloprotease DUF5595 PF18077.1 EKX73169.1 - 1.9e-05 24.6 0.1 4.2e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5595) UBA_4 PF14555.6 EKX73170.1 - 0.098 12.5 0.1 0.27 11.1 0.1 1.8 1 0 0 1 1 1 0 UBA-like domain DUF1296 PF06972.11 EKX73170.1 - 0.39 10.9 2.6 3.2 8.0 1.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1296) Lyase_1 PF00206.20 EKX73171.1 - 3.4e-39 135.1 0.0 5.2e-39 134.5 0.0 1.1 1 0 0 1 1 1 1 Lyase ASL_C PF08328.11 EKX73171.1 - 1.7e-32 111.9 0.0 8.6e-32 109.6 0.0 2.1 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminal hnRNP_Q_AcD PF18360.1 EKX73171.1 - 0.035 14.1 0.2 1.5 8.8 0.0 2.8 3 0 0 3 3 3 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain DUF2150 PF09920.9 EKX73171.1 - 0.084 12.8 0.1 3.1 7.8 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2150) Pou PF00157.17 EKX73171.1 - 0.15 12.0 0.1 0.51 10.3 0.1 1.9 1 0 0 1 1 1 0 Pou domain - N-terminal to homeobox domain Ribosomal_S9 PF00380.19 EKX73172.1 - 2e-22 80.0 0.0 3.1e-22 79.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Peptidase_C93 PF06035.11 EKX73172.1 - 0.11 12.3 0.1 0.17 11.7 0.1 1.3 1 0 0 1 1 1 0 Bacterial transglutaminase-like cysteine proteinase BTLCP Ras PF00071.22 EKX73173.1 - 2.5e-62 209.2 2.0 3.4e-62 208.8 2.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKX73173.1 - 2.9e-34 117.8 0.4 5.6e-34 116.9 0.4 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKX73173.1 - 2.9e-17 62.7 0.3 3.4e-17 62.5 0.3 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EKX73173.1 - 1.3e-05 24.7 0.6 5.1e-05 22.8 0.2 1.9 1 1 0 2 2 2 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EKX73173.1 - 2.4e-05 23.8 0.3 3.1e-05 23.5 0.3 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EKX73173.1 - 3e-05 24.0 0.3 5.4e-05 23.2 0.3 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKX73173.1 - 5.6e-05 22.8 1.5 0.00032 20.3 1.5 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EKX73173.1 - 0.00015 21.8 2.6 0.19 11.6 0.1 2.3 1 1 1 2 2 2 2 RsgA GTPase ATP_bind_1 PF03029.17 EKX73173.1 - 0.0013 18.6 0.2 0.011 15.6 0.1 1.9 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 EKX73173.1 - 0.0032 17.2 0.9 0.047 13.4 0.9 2.4 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 EKX73173.1 - 0.0083 16.4 0.1 0.025 14.8 0.0 2.0 1 1 1 2 2 2 1 AAA domain CPT PF07931.12 EKX73173.1 - 0.0094 15.8 0.0 0.016 15.0 0.0 1.3 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_16 PF13191.6 EKX73173.1 - 0.011 16.2 0.0 0.013 15.9 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain cobW PF02492.19 EKX73173.1 - 0.014 15.0 0.7 0.61 9.7 0.1 2.1 1 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 EKX73173.1 - 0.018 15.5 0.6 0.033 14.7 0.6 1.7 1 1 0 1 1 1 0 ABC transporter Septin PF00735.18 EKX73173.1 - 0.026 13.8 0.2 0.08 12.2 0.0 1.8 2 0 0 2 2 2 0 Septin AAA_5 PF07728.14 EKX73173.1 - 0.035 14.1 0.0 0.082 12.9 0.0 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ATPase_2 PF01637.18 EKX73173.1 - 0.042 13.8 3.2 0.77 9.6 3.2 2.0 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea NACHT PF05729.12 EKX73173.1 - 0.046 13.7 0.0 0.076 12.9 0.0 1.3 1 0 0 1 1 1 0 NACHT domain PRK PF00485.18 EKX73173.1 - 0.058 13.1 0.6 0.29 10.8 0.1 2.0 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Peptidase_S21 PF00716.17 EKX73173.1 - 0.08 12.6 0.1 0.098 12.3 0.1 1.1 1 0 0 1 1 1 0 Assemblin (Peptidase family S21) Methyltransf_31 PF13847.6 EKX73173.1 - 0.081 12.7 0.1 0.23 11.3 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain AAA_7 PF12775.7 EKX73173.1 - 0.1 12.1 0.4 0.33 10.5 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region CBS PF00571.28 EKX73174.1 - 5.1e-14 52.5 0.3 0.0001 22.7 0.1 4.0 4 0 0 4 4 4 3 CBS domain VirDNA-topo-I_N PF09266.10 EKX73174.1 - 0.056 13.6 0.2 17 5.6 0.1 2.9 2 0 0 2 2 2 0 Viral DNA topoisomerase I, N-terminal RNA_pol_L PF01193.24 EKX73174.1 - 0.17 11.3 0.1 11 5.5 0.0 2.5 2 0 0 2 2 2 0 RNA polymerase Rpb3/Rpb11 dimerisation domain CENP-H PF05837.12 EKX73176.1 - 0.021 15.2 2.6 0.025 15.0 0.9 1.9 2 0 0 2 2 2 0 Centromere protein H (CENP-H) 2-oxoacid_dh PF00198.23 EKX73176.1 - 0.057 12.9 0.4 0.22 11.0 0.0 1.9 2 0 0 2 2 2 0 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Cnn_1N PF07989.11 EKX73176.1 - 0.065 13.4 5.0 0.14 12.3 5.0 1.5 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 DASH_Dad3 PF08656.10 EKX73176.1 - 0.11 12.6 4.6 0.054 13.6 1.8 2.0 2 0 0 2 2 2 0 DASH complex subunit Dad3 DivIC PF04977.15 EKX73176.1 - 6.8 6.5 6.6 10 6.0 3.2 2.3 2 1 0 2 2 2 0 Septum formation initiator TetR_C_19 PF17924.1 EKX73177.1 - 0.29 11.7 4.5 0.42 11.2 0.3 2.6 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain DUF2753 PF10952.8 EKX73179.1 - 0.032 14.4 0.1 0.059 13.5 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2753) NUC153 PF08159.12 EKX73180.1 - 3.8e-07 29.8 3.7 8.9e-07 28.6 1.2 2.8 2 0 0 2 2 2 1 NUC153 domain DUF4820 PF16091.5 EKX73180.1 - 3.6 6.9 10.5 1.6 8.1 1.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Proteasom_PSMB PF10508.9 EKX73181.1 - 1.8e-06 26.8 0.4 0.00029 19.5 0.1 2.8 2 1 0 2 2 2 2 Proteasome non-ATPase 26S subunit RE_R_Pab1 PF09522.10 EKX73181.1 - 0.083 13.0 0.2 0.48 10.6 0.1 2.3 2 0 0 2 2 2 0 R.Pab1 restriction endonuclease Cpn60_TCP1 PF00118.24 EKX73183.1 - 2.4e-142 475.0 2.1 2.7e-142 474.8 2.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family RF-1 PF00472.20 EKX73184.1 - 2.4e-16 59.7 4.0 3.3e-16 59.3 4.0 1.1 1 0 0 1 1 1 1 RF-1 domain MRP-S28 PF10213.9 EKX73184.1 - 2.2e-05 24.9 1.2 2.8e-05 24.5 1.2 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein OAM_alpha PF16552.5 EKX73186.1 - 0.13 12.1 0.0 0.17 11.7 0.0 1.1 1 0 0 1 1 1 0 D-ornithine 4,5-aminomutase alpha-subunit W2 PF02020.18 EKX73187.1 - 0.0016 18.5 2.7 0.0033 17.5 0.8 2.5 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon TAF1_subA PF14929.6 EKX73187.1 - 0.0097 15.4 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 TAF RNA Polymerase I subunit A CBFB_NFYA PF02045.15 EKX73188.1 - 0.0004 21.0 0.8 0.00096 19.7 0.8 1.6 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B DAO PF01266.24 EKX73189.1 - 5.3e-39 134.8 0.0 8e-39 134.2 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 EKX73189.1 - 2e-35 121.4 0.0 3.5e-35 120.6 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 EKX73189.1 - 3.1e-08 33.1 0.4 3.2e-06 26.5 0.2 2.1 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EKX73189.1 - 0.00017 20.9 0.1 0.0015 17.9 0.0 2.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EKX73189.1 - 0.00024 20.5 0.0 0.046 13.0 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.7 EKX73189.1 - 0.00045 19.7 0.3 0.00081 18.8 0.3 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 EKX73189.1 - 0.0029 16.8 0.6 0.014 14.5 0.2 1.9 2 0 0 2 2 2 1 Glucose inhibited division protein A Thi4 PF01946.17 EKX73189.1 - 0.061 12.6 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 EKX73189.1 - 0.11 11.2 0.1 0.16 10.6 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_8 PF13450.6 EKX73189.1 - 0.12 12.6 0.3 0.24 11.6 0.3 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EKX73189.1 - 0.14 11.1 0.1 0.26 10.3 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Sec63 PF02889.16 EKX73191.1 - 3.6e-134 445.8 0.0 3e-78 262.5 0.1 2.5 2 0 0 2 2 2 2 Sec63 Brl domain Helicase_PWI PF18149.1 EKX73191.1 - 7.4e-33 113.1 2.2 1.4e-32 112.1 0.4 2.5 2 0 0 2 2 2 1 N-terminal helicase PWI domain DEAD PF00270.29 EKX73191.1 - 7.8e-32 110.4 0.0 6.3e-24 84.7 0.0 2.6 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 EKX73191.1 - 1.2e-11 44.9 1.5 4.6e-08 33.4 0.0 4.7 4 1 0 4 4 4 2 Helicase conserved C-terminal domain ResIII PF04851.15 EKX73191.1 - 2.3e-11 44.0 0.0 5.7e-11 42.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EKX73191.1 - 0.034 14.4 0.4 0.46 10.7 0.2 2.8 2 1 0 2 2 2 0 AAA domain RNA_pol_Rpb2_6 PF00562.28 EKX73192.1 - 3.6e-115 385.1 0.2 2e-114 382.7 0.2 2.0 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EKX73192.1 - 2.2e-42 144.9 0.2 5e-24 84.9 0.1 2.3 2 0 0 2 2 2 2 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 EKX73192.1 - 2.2e-31 108.1 0.1 5.8e-31 106.7 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 EKX73192.1 - 2e-22 79.3 1.8 4.7e-22 78.1 1.8 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_2 PF04561.14 EKX73192.1 - 1.9e-17 63.5 0.2 2.1e-16 60.1 0.2 2.2 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.16 EKX73192.1 - 8.3e-17 61.1 0.0 2.2e-16 59.8 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EKX73192.1 - 2.7e-07 31.0 2.5 3.2e-07 30.8 0.4 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 5 Ribosom_S12_S23 PF00164.25 EKX73193.1 - 5e-50 167.9 0.4 6.5e-50 167.5 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Ribosomal_L30 PF00327.20 EKX73194.1 - 8.3e-15 54.4 2.5 1.8e-14 53.3 2.5 1.6 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.12 EKX73194.1 - 1.4e-14 54.1 14.2 2.3e-14 53.4 14.2 1.3 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Radial_spoke_3 PF06098.11 EKX73194.1 - 0.45 9.8 6.8 0.6 9.3 6.8 1.1 1 0 0 1 1 1 0 Radial spoke protein 3 CH PF00307.31 EKX73195.1 - 7.4e-10 39.0 0.5 7.4e-10 39.0 0.5 2.1 3 0 0 3 3 3 1 Calponin homology (CH) domain EB1 PF03271.17 EKX73195.1 - 2.5e-09 37.2 1.2 1.8e-08 34.5 0.5 2.5 2 0 0 2 2 2 1 EB1-like C-terminal motif Vfa1 PF08432.10 EKX73195.1 - 0.015 15.6 4.7 0.03 14.7 4.7 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CAMSAP_CH PF11971.8 EKX73195.1 - 0.022 14.6 0.1 0.062 13.1 0.1 1.8 1 1 0 1 1 1 0 CAMSAP CH domain RPW8 PF05659.11 EKX73195.1 - 3.2 7.5 8.2 0.41 10.3 3.1 2.1 3 1 0 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 ATG16 PF08614.11 EKX73196.1 - 4.3e-05 23.8 3.8 4.3e-05 23.8 3.8 2.2 2 1 0 2 2 2 1 Autophagy protein 16 (ATG16) Trimer_CC PF08954.11 EKX73196.1 - 0.00013 21.5 3.5 0.013 15.1 0.2 2.9 3 0 0 3 3 3 1 Trimerisation motif FAM184 PF15665.5 EKX73196.1 - 0.00052 19.9 3.5 0.00052 19.9 3.5 1.6 2 0 0 2 2 2 1 Family with sequence similarity 184, A and B PAH PF02671.21 EKX73196.1 - 0.001 19.1 0.3 0.0028 17.8 0.3 1.8 1 0 0 1 1 1 1 Paired amphipathic helix repeat Spc7 PF08317.11 EKX73196.1 - 0.0017 17.3 7.3 0.0028 16.6 5.4 1.9 2 0 0 2 2 2 1 Spc7 kinetochore protein FapA PF03961.13 EKX73196.1 - 0.0026 16.4 3.3 0.0037 15.9 3.3 1.2 1 0 0 1 1 1 1 Flagellar Assembly Protein A HAUS-augmin3 PF14932.6 EKX73196.1 - 0.0038 16.9 6.9 0.038 13.6 5.4 2.0 2 0 0 2 2 2 1 HAUS augmin-like complex subunit 3 TPR_MLP1_2 PF07926.12 EKX73196.1 - 0.0045 17.1 7.5 0.038 14.0 6.6 2.1 2 0 0 2 2 2 1 TPR/MLP1/MLP2-like protein TMF_DNA_bd PF12329.8 EKX73196.1 - 0.0048 16.9 11.9 0.026 14.5 9.5 2.9 2 1 0 2 2 2 1 TATA element modulatory factor 1 DNA binding Scaffolding_pro PF11418.8 EKX73196.1 - 0.006 17.1 1.8 0.011 16.3 0.8 1.9 2 0 0 2 2 1 1 Phi29 scaffolding protein Filament PF00038.21 EKX73196.1 - 0.0062 16.2 5.5 0.025 14.2 4.4 2.0 2 0 0 2 2 2 1 Intermediate filament protein DASH_Spc34 PF08657.10 EKX73196.1 - 0.0086 15.9 3.0 0.013 15.4 2.2 1.6 2 0 0 2 2 1 1 DASH complex subunit Spc34 DUF4201 PF13870.6 EKX73196.1 - 0.013 15.2 10.1 0.12 12.1 8.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) FliJ PF02050.16 EKX73196.1 - 0.018 15.2 6.5 0.099 12.9 4.9 2.1 2 0 0 2 2 2 0 Flagellar FliJ protein ABC_tran_CTD PF16326.5 EKX73196.1 - 0.023 14.9 6.7 0.083 13.2 1.8 2.9 2 1 1 3 3 3 0 ABC transporter C-terminal domain GIT_CC PF16559.5 EKX73196.1 - 0.027 14.3 0.7 0.027 14.3 0.7 2.9 3 1 1 4 4 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor APG6_N PF17675.1 EKX73196.1 - 0.034 14.7 8.5 0.028 14.9 6.2 1.9 2 0 0 2 2 2 0 Apg6 coiled-coil region STAT_alpha PF01017.20 EKX73196.1 - 0.04 13.8 10.1 0.022 14.7 7.8 1.6 2 0 0 2 2 2 0 STAT protein, all-alpha domain Mt_ATP-synt_D PF05873.12 EKX73196.1 - 0.074 12.9 1.8 0.12 12.2 1.0 1.8 2 1 0 2 2 1 0 ATP synthase D chain, mitochondrial (ATP5H) Exonuc_VII_L PF02601.15 EKX73196.1 - 0.076 12.6 6.2 0.044 13.3 4.1 1.5 2 0 0 2 2 2 0 Exonuclease VII, large subunit Mating_N PF12731.7 EKX73196.1 - 0.097 12.8 7.0 2.2 8.4 0.2 3.5 2 1 1 3 3 3 0 Mating-type protein beta 1 Uso1_p115_C PF04871.13 EKX73196.1 - 0.12 12.8 10.2 0.049 14.0 7.9 1.6 2 0 0 2 2 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF4407 PF14362.6 EKX73196.1 - 0.13 11.5 4.3 0.16 11.3 4.3 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1722 PF08349.11 EKX73196.1 - 0.15 12.4 5.1 23 5.3 0.2 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1722) DUF16 PF01519.16 EKX73196.1 - 0.15 12.6 4.2 0.5 10.9 3.9 1.9 2 0 0 2 2 2 0 Protein of unknown function DUF16 OmpH PF03938.14 EKX73196.1 - 0.19 12.0 6.5 0.27 11.6 4.8 1.9 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF1192 PF06698.11 EKX73196.1 - 0.21 11.7 4.3 3.8 7.6 0.4 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) TMF_TATA_bd PF12325.8 EKX73196.1 - 0.25 11.6 9.2 0.63 10.3 7.5 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Phage_GP20 PF06810.11 EKX73196.1 - 0.27 11.1 7.7 1.4 8.7 4.5 2.7 2 1 0 2 2 2 0 Phage minor structural protein GP20 ADIP PF11559.8 EKX73196.1 - 0.29 11.2 10.8 0.11 12.6 7.9 1.9 2 0 0 2 2 1 0 Afadin- and alpha -actinin-Binding Cep57_MT_bd PF06657.13 EKX73196.1 - 0.3 11.5 6.2 0.58 10.7 4.5 2.3 2 1 0 2 2 1 0 Centrosome microtubule-binding domain of Cep57 DUF3450 PF11932.8 EKX73196.1 - 0.39 10.0 8.0 1.3 8.3 7.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Syntaxin-6_N PF09177.11 EKX73196.1 - 0.39 11.3 6.3 0.39 11.3 3.9 2.2 2 1 1 3 3 1 0 Syntaxin 6, N-terminal DUF1664 PF07889.12 EKX73196.1 - 0.4 10.7 6.3 11 6.1 0.1 2.5 2 1 1 3 3 2 0 Protein of unknown function (DUF1664) DUF1843 PF08898.10 EKX73196.1 - 0.4 11.2 3.0 13 6.4 0.4 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF1843) bZIP_1 PF00170.21 EKX73196.1 - 0.46 10.6 8.6 0.13 12.3 1.7 2.9 2 1 1 3 3 2 0 bZIP transcription factor DUF5082 PF16888.5 EKX73196.1 - 0.5 10.7 8.3 2 8.7 2.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) Fib_alpha PF08702.10 EKX73196.1 - 0.57 10.4 7.0 3 8.0 0.5 2.4 2 1 0 2 2 1 0 Fibrinogen alpha/beta chain family Jnk-SapK_ap_N PF09744.9 EKX73196.1 - 0.61 10.3 11.2 0.094 12.9 2.8 2.6 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 Fez1 PF06818.15 EKX73196.1 - 0.8 10.1 10.0 1.8 9.0 9.8 1.6 1 1 0 1 1 1 0 Fez1 Sec34 PF04136.15 EKX73196.1 - 0.88 9.4 8.0 0.58 10.0 6.0 1.7 2 0 0 2 2 2 0 Sec34-like family KLRAQ PF10205.9 EKX73196.1 - 0.89 9.8 10.9 0.27 11.5 7.6 1.8 2 1 0 2 2 1 0 Predicted coiled-coil domain-containing protein Cep57_CLD_2 PF14197.6 EKX73196.1 - 0.91 9.7 7.6 1.2 9.2 4.9 2.3 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 CENP-H PF05837.12 EKX73196.1 - 1.3 9.5 9.4 0.68 10.4 6.2 2.1 2 1 0 2 2 1 0 Centromere protein H (CENP-H) KxDL PF10241.9 EKX73196.1 - 1.4 9.3 9.3 16 5.9 0.1 2.7 2 1 0 2 2 2 0 Uncharacterized conserved protein DivIC PF04977.15 EKX73196.1 - 1.4 8.7 9.6 0.63 9.8 3.4 2.8 2 1 1 3 3 3 0 Septum formation initiator Wtap PF17098.5 EKX73196.1 - 1.4 8.8 10.0 0.28 11.1 6.1 1.7 2 0 0 2 2 2 0 WTAP/Mum2p family SlyX PF04102.12 EKX73196.1 - 1.8 9.3 8.7 3.4 8.3 2.4 2.6 2 1 1 3 3 2 0 SlyX FAM76 PF16046.5 EKX73196.1 - 2.2 7.5 8.3 1.5 8.1 6.6 1.5 1 1 1 2 2 2 0 FAM76 protein zf-C4H2 PF10146.9 EKX73196.1 - 3.4 7.9 7.3 3 8.1 6.2 1.4 1 1 0 1 1 1 0 Zinc finger-containing protein Swi5 PF07061.11 EKX73196.1 - 4.4 7.5 7.9 79 3.4 4.8 3.2 2 1 0 2 2 2 0 Swi5 DUF4094 PF13334.6 EKX73196.1 - 4.6 7.7 6.6 24 5.4 0.1 2.9 3 1 0 3 3 2 0 Domain of unknown function (DUF4094) Sec2p PF06428.11 EKX73196.1 - 4.7 7.2 11.7 0.32 11.0 0.6 3.0 2 1 1 3 3 3 0 GDP/GTP exchange factor Sec2p ZapB PF06005.12 EKX73196.1 - 4.9 7.7 14.5 2.9 8.4 1.9 3.1 2 1 1 3 3 3 0 Cell division protein ZapB Prefoldin PF02996.17 EKX73196.1 - 7.6 6.5 10.2 13 5.8 0.6 2.7 2 1 0 3 3 3 0 Prefoldin subunit YabA PF06156.13 EKX73196.1 - 8.2 7.1 8.3 8.4 7.1 6.0 2.3 2 1 0 2 2 1 0 Initiation control protein YabA KIP1 PF07765.12 EKX73196.1 - 8.4 6.6 6.7 9.9 6.4 0.2 2.8 2 1 1 3 3 2 0 KIP1-like protein Atracotoxin PF05353.11 EKX73198.1 - 0.053 13.6 1.9 0.18 11.9 1.9 1.9 1 0 0 1 1 1 0 Delta Atracotoxin Insulin_TMD PF17870.1 EKX73198.1 - 0.59 10.2 3.3 0.58 10.3 0.8 2.4 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment DUF2583 PF10762.9 EKX73198.1 - 5.1 7.6 7.8 2.9 8.4 1.3 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2583) FAINT PF04385.15 EKX73199.1 - 2.1e-18 66.1 22.2 2.3e-09 37.2 1.2 5.6 6 1 0 6 6 6 3 Domain of unknown function, DUF529 Hydrolase_4 PF12146.8 EKX73199.1 - 1.4e-14 53.9 0.0 1.3e-12 47.5 0.0 2.8 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EKX73199.1 - 7.8e-05 22.4 0.0 0.00015 21.5 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF900 PF05990.12 EKX73199.1 - 0.042 13.4 0.0 0.082 12.4 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) DUF1892 PF08987.10 EKX73199.1 - 0.1 12.8 0.0 0.29 11.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1892) RRM_1 PF00076.22 EKX73200.1 - 5.2e-06 26.2 0.1 4.3e-05 23.2 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YajC PF02699.15 EKX73200.1 - 0.015 15.1 0.6 0.05 13.5 0.6 2.0 1 0 0 1 1 1 0 Preprotein translocase subunit DUF2187 PF09953.9 EKX73200.1 - 0.052 13.6 0.2 0.15 12.0 0.2 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2187) DUF2206 PF09971.9 EKX73200.1 - 0.19 10.5 3.7 0.4 9.4 3.7 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) zf-Tim10_DDP PF02953.15 EKX73201.1 - 4.3e-14 51.9 0.9 5.8e-14 51.5 0.9 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger MPC PF03650.13 EKX73202.1 - 4.5e-33 113.7 0.2 5e-33 113.5 0.2 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers WD40 PF00400.32 EKX73203.1 - 2.7e-42 141.9 17.5 2.1e-07 31.5 0.2 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKX73203.1 - 1.3e-13 51.1 1.9 0.0049 17.1 0.1 5.9 3 2 2 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EKX73203.1 - 1.2e-05 24.4 4.3 0.0077 15.2 1.6 3.8 2 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 EKX73203.1 - 7.2e-05 21.0 1.0 0.00047 18.3 0.3 2.0 2 0 0 2 2 2 1 IKI3 family zf-C2H2 PF00096.26 EKX73204.1 - 2.4e-21 74.9 29.1 1.1e-05 25.6 3.4 5.4 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EKX73204.1 - 4.6e-17 61.3 25.0 0.00041 20.9 2.4 5.3 5 0 0 5 5 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EKX73204.1 - 5.8e-13 48.6 31.5 5.1e-05 23.5 4.7 5.8 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2_6 PF13912.6 EKX73204.1 - 3.3e-07 30.1 25.0 0.033 14.2 1.1 5.3 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EKX73204.1 - 7.6e-06 26.1 14.9 7.6e-05 22.9 2.7 3.2 1 1 2 3 3 3 1 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 EKX73204.1 - 2.8e-05 24.3 11.3 0.27 11.6 1.2 3.9 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 EKX73204.1 - 4.6e-05 23.1 7.2 0.00032 20.4 1.4 4.8 6 0 0 6 6 6 2 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 EKX73204.1 - 8.8e-05 22.5 14.7 0.029 14.5 2.8 3.8 4 0 0 4 4 4 2 Zinc ribbon domain zf-H2C2_5 PF13909.6 EKX73204.1 - 0.00079 19.1 12.2 0.0015 18.3 2.3 3.0 2 0 0 2 2 2 1 C2H2-type zinc-finger domain zf-LYAR PF08790.11 EKX73204.1 - 0.00094 19.0 11.6 0.068 13.1 0.2 4.7 5 0 0 5 5 5 2 LYAR-type C2HC zinc finger zf-C2HC_2 PF13913.6 EKX73204.1 - 0.0011 18.8 11.7 0.64 10.0 1.2 4.7 4 0 0 4 4 4 1 zinc-finger of a C2HC-type zf_UBZ PF18439.1 EKX73204.1 - 0.0012 18.4 13.5 0.07 12.7 0.1 4.6 5 0 0 5 5 5 2 Ubiquitin-Binding Zinc Finger XPA_N PF01286.18 EKX73204.1 - 0.0065 16.5 9.5 3.8 7.6 0.5 3.8 3 0 0 3 3 3 2 XPA protein N-terminal zf-C2H2_9 PF16293.5 EKX73204.1 - 0.011 15.6 4.5 1 9.3 0.2 3.3 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-Di19 PF05605.12 EKX73204.1 - 0.016 15.5 16.6 0.44 10.9 4.5 4.1 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding Marek_A PF02124.15 EKX73204.1 - 0.056 13.3 0.6 0.074 12.9 0.1 1.5 2 0 0 2 2 2 0 Marek's disease glycoprotein A C1_1 PF00130.22 EKX73204.1 - 0.074 12.9 9.8 1.3 8.9 2.1 3.6 2 1 2 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-met PF12874.7 EKX73204.1 - 0.12 12.8 10.1 1.2 9.7 0.3 4.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-BED PF02892.15 EKX73204.1 - 0.17 11.9 16.6 0.3 11.1 1.2 3.6 2 2 1 3 3 3 0 BED zinc finger CpXC PF14353.6 EKX73204.1 - 0.17 11.9 10.9 0.62 10.1 0.3 3.0 1 1 2 3 3 3 0 CpXC protein HNH PF01844.23 EKX73204.1 - 0.77 10.0 9.3 11 6.3 0.1 4.1 4 0 0 4 4 4 0 HNH endonuclease Desulfoferrod_N PF06397.12 EKX73204.1 - 1.6 8.4 8.8 6.7 6.4 0.3 3.2 3 0 0 3 3 3 0 Desulfoferrodoxin, N-terminal domain zf-MYST PF17772.1 EKX73204.1 - 8.6 6.1 11.3 4.7 6.9 0.1 3.6 4 0 0 4 4 4 0 MYST family zinc finger domain LSM PF01423.22 EKX73205.1 - 7.1e-19 67.3 0.0 8.4e-19 67.0 0.0 1.1 1 0 0 1 1 1 1 LSM domain DUF150_C PF17384.2 EKX73205.1 - 0.019 15.1 0.1 0.05 13.7 0.0 1.7 1 1 0 1 1 1 0 RimP C-terminal SH3 domain Mago-bind PF09282.10 EKX73206.1 - 1.1e-13 50.7 0.4 1.9e-13 50.0 0.4 1.4 1 0 0 1 1 1 1 Mago binding DUF2012 PF09430.10 EKX73207.1 - 0.00061 19.9 0.3 0.0012 18.9 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) ETRAMP PF09716.10 EKX73207.1 - 0.13 12.3 0.3 0.35 11.0 0.3 1.6 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) eIF-5_eIF-2B PF01873.17 EKX73208.1 - 4e-35 120.2 0.0 6.9e-35 119.5 0.0 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 EKX73208.1 - 2.6e-07 30.7 0.0 6.1e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Neur_chan_memb PF02932.16 EKX73208.1 - 0.02 15.0 0.0 0.025 14.6 0.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ski_Sno PF02437.17 EKX73208.1 - 0.052 13.3 0.1 0.18 11.6 0.1 1.8 2 0 0 2 2 2 0 SKI/SNO/DAC family DUF2387 PF09526.10 EKX73208.1 - 0.1 12.8 0.2 0.2 11.8 0.2 1.5 1 0 0 1 1 1 0 Probable metal-binding protein (DUF2387) Ribosomal_L7Ae PF01248.26 EKX73209.1 - 4.1e-23 80.9 0.2 5.2e-23 80.6 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family SpoU_sub_bind PF08032.12 EKX73209.1 - 0.075 13.3 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 RNA 2'-O ribose methyltransferase substrate binding Ribosomal_S19e PF01090.19 EKX73210.1 - 5.6e-50 168.6 0.0 6.5e-50 168.4 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e GDI PF00996.18 EKX73211.1 - 6.8e-201 667.4 0.0 7.8e-201 667.2 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor Amino_oxidase PF01593.24 EKX73211.1 - 0.0052 16.1 0.0 0.0082 15.5 0.0 1.4 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase SH3_14 PF18343.1 EKX73211.1 - 0.044 13.9 0.1 0.3 11.2 0.0 2.4 2 1 1 3 3 3 0 Dda helicase SH3 domain NAD_binding_8 PF13450.6 EKX73211.1 - 0.054 13.7 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain SWIRM PF04433.17 EKX73212.1 - 1.7e-24 85.9 0.0 4.2e-24 84.7 0.0 1.7 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-binding PF00249.31 EKX73212.1 - 3.5e-11 43.1 0.1 1.1e-10 41.5 0.0 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EKX73212.1 - 3.5e-07 30.4 0.0 1.1e-06 28.7 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM-assoc_1 PF16495.5 EKX73212.1 - 2.9e-06 27.1 7.0 5.6e-06 26.2 7.0 1.4 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-bind_7 PF15963.5 EKX73212.1 - 0.00062 19.6 0.9 0.0015 18.3 0.0 2.1 2 0 0 2 2 2 1 Myb DNA-binding like PP1_bind PF15276.6 EKX73212.1 - 0.31 11.4 1.3 0.94 9.8 0.1 2.5 2 0 0 2 2 2 0 Protein phosphatase 1 binding PPTA PF01239.22 EKX73214.1 - 1.2e-23 82.1 16.4 1.5e-05 24.5 0.1 5.4 6 0 0 6 6 6 4 Protein prenyltransferase alpha subunit repeat DUF485 PF04341.12 EKX73215.1 - 8.7 6.4 11.5 0.71 9.9 4.9 2.7 2 0 0 2 2 2 0 Protein of unknown function, DUF485 EMA PF02488.15 EKX73216.1 - 1.4e-32 113.3 12.4 1.7e-32 113.1 12.4 1.0 1 0 0 1 1 1 1 Merozoite Antigen FAINT PF04385.15 EKX73216.1 - 0.057 13.5 2.4 0.26 11.4 0.2 2.7 2 1 1 3 3 3 0 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73217.1 - 5.8e-08 32.7 11.8 0.0018 18.3 2.4 3.6 3 0 0 3 3 3 3 Domain of unknown function, DUF529 Ribosomal_S17e PF00833.18 EKX73219.1 - 1.8e-57 192.5 0.4 2.1e-57 192.3 0.4 1.0 1 0 0 1 1 1 1 Ribosomal S17 Arm-DNA-bind_2 PF12167.8 EKX73219.1 - 0.042 13.8 0.1 0.079 12.9 0.1 1.5 1 0 0 1 1 1 0 Arm DNA-binding domain Met_10 PF02475.16 EKX73220.1 - 9.5e-54 182.2 4.3 4.3e-53 180.0 4.3 1.9 1 1 0 1 1 1 1 Met-10+ like-protein MethyltransfD12 PF02086.15 EKX73220.1 - 0.044 13.5 0.3 0.15 11.7 0.2 1.9 2 1 0 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase SET PF00856.28 EKX73221.1 - 5.8e-06 26.8 0.7 8.8e-06 26.2 0.7 1.7 1 1 0 1 1 1 1 SET domain DUF4367 PF14285.6 EKX73221.1 - 0.66 10.4 4.0 2.1 8.8 0.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4367) Ribosomal_L28e PF01778.17 EKX73223.1 - 2.8e-29 102.2 0.7 2.8e-29 102.2 0.7 1.9 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 EKX73223.1 - 5e-19 68.8 3.1 5e-19 68.8 3.1 1.7 2 0 0 2 2 2 1 Mak16 protein C-terminal region DUF3523 PF12037.8 EKX73224.1 - 1.4e-84 283.6 25.3 2e-84 283.1 25.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3523) AAA PF00004.29 EKX73224.1 - 5.4e-26 91.6 0.0 1.2e-25 90.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EKX73224.1 - 2.9e-07 30.4 0.1 1.3e-06 28.3 0.0 2.2 2 1 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EKX73224.1 - 0.0003 21.2 8.6 0.0023 18.3 0.0 3.5 2 2 1 3 3 2 1 AAA ATPase domain AAA_5 PF07728.14 EKX73224.1 - 0.00033 20.6 0.1 0.0061 16.6 0.1 2.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EKX73224.1 - 0.0013 18.5 0.1 0.0046 16.7 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EKX73224.1 - 0.0014 18.7 2.0 0.014 15.6 0.0 2.9 2 1 0 3 3 3 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EKX73224.1 - 0.0015 18.8 7.5 0.017 15.4 0.1 3.3 2 2 0 3 3 2 1 AAA domain AAA_18 PF13238.6 EKX73224.1 - 0.0034 17.9 3.6 0.0084 16.6 0.0 3.2 3 1 0 3 3 3 1 AAA domain AAA_7 PF12775.7 EKX73224.1 - 0.0049 16.4 0.0 0.013 15.1 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region TsaE PF02367.17 EKX73224.1 - 0.009 16.0 0.2 0.058 13.4 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 EKX73224.1 - 0.015 15.5 4.3 0.015 15.5 0.0 3.0 3 1 0 3 3 3 0 AAA domain Mg_chelatase PF01078.21 EKX73224.1 - 0.025 14.0 3.3 0.026 13.9 0.0 2.6 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EKX73224.1 - 0.03 14.4 0.0 0.12 12.4 0.0 2.1 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 EKX73224.1 - 0.036 14.2 0.1 0.14 12.3 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain RNA_helicase PF00910.22 EKX73224.1 - 0.041 14.3 0.0 0.11 12.9 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_17 PF13207.6 EKX73224.1 - 0.048 14.1 0.0 0.048 14.1 0.0 3.4 2 1 1 3 3 3 0 AAA domain AAA_3 PF07726.11 EKX73224.1 - 0.061 13.2 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 EKX73224.1 - 0.071 12.9 25.9 0.37 10.5 0.0 3.2 2 1 0 2 2 1 0 AAA domain AAA_lid_3 PF17862.1 EKX73224.1 - 0.12 12.2 0.0 0.35 10.7 0.0 1.7 1 0 0 1 1 1 0 AAA+ lid domain V_ATPase_I PF01496.19 EKX73224.1 - 1.5 6.7 11.5 1.9 6.3 11.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_28 PF13521.6 EKX73224.1 - 1.7 8.9 0.0 1.7 8.9 0.0 3.7 3 1 0 3 3 2 0 AAA domain Ins_P5_2-kin PF06090.12 EKX73225.1 - 1.5e-12 47.6 4.9 3.5e-12 46.4 4.9 1.6 1 1 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase Pep1_7 PF17232.2 EKX73225.1 - 0.11 13.0 0.5 2.4 8.7 0.1 2.5 2 0 0 2 2 2 0 Elicitor peptide 1-7 Pkinase PF00069.25 EKX73226.1 - 7e-48 163.3 0.0 9.4e-47 159.6 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKX73226.1 - 1e-17 64.3 0.0 1.2e-15 57.5 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKX73226.1 - 0.12 11.7 0.0 30 3.8 0.0 3.0 3 0 0 3 3 3 0 Kinase-like Rpr2 PF04032.16 EKX73227.1 - 4.7e-10 39.6 1.3 5.7e-10 39.4 1.3 1.2 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain BRCC36_C PF18110.1 EKX73227.1 - 0.045 13.9 0.1 0.078 13.1 0.1 1.4 1 1 0 1 1 1 0 BRCC36 C-terminal helical domain DUF2325 PF10087.9 EKX73227.1 - 0.094 12.8 2.9 0.17 12.0 0.2 2.4 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2325) SRP40_C PF05022.12 EKX73228.1 - 1.6e-19 70.5 2.3 1.6e-19 70.5 2.3 2.0 2 0 0 2 2 2 1 SRP40, C-terminal domain Pkinase PF00069.25 EKX73230.1 - 1.7e-11 44.0 0.5 6.4e-07 29.0 0.2 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EKX73230.1 - 4.9e-07 29.3 0.0 0.0009 18.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase GTP_EFTU PF00009.27 EKX73231.1 - 1.1e-54 184.9 0.0 1.5e-54 184.5 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EKX73231.1 - 2.2e-21 76.3 0.0 6.4e-21 74.8 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EKX73231.1 - 1.3e-15 57.5 4.9 2.5e-15 56.6 4.9 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EKX73231.1 - 6.5e-05 23.0 0.0 0.00013 22.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKX73231.1 - 0.017 15.0 0.0 0.052 13.5 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase cobW PF02492.19 EKX73231.1 - 0.02 14.5 0.1 0.047 13.3 0.0 1.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU_D4 PF14578.6 EKX73231.1 - 0.16 11.9 2.9 0.47 10.4 2.4 2.0 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Polyoma_lg_T_C PF06431.11 EKX73231.1 - 0.2 10.5 0.1 2.6 6.8 0.0 2.0 2 0 0 2 2 2 0 Polyomavirus large T antigen C-terminus BROMI PF14961.6 EKX73231.1 - 0.3 8.4 0.0 0.41 8.0 0.0 1.1 1 0 0 1 1 1 0 Broad-minded protein TMA7 PF09072.10 EKX73232.1 - 1e-06 29.4 12.8 2.4e-06 28.3 12.8 1.6 1 1 0 1 1 1 1 Translation machinery associated TMA7 Ribosomal_S3Ae PF01015.18 EKX73233.1 - 8.5e-87 289.9 0.3 1e-86 289.7 0.3 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Ints3 PF10189.9 EKX73234.1 - 0.00018 20.9 9.5 0.32 10.2 0.1 4.2 4 0 0 4 4 4 3 Integrator complex subunit 3 PX PF00787.24 EKX73235.1 - 2e-12 47.1 0.3 6.7e-12 45.4 0.3 2.0 1 0 0 1 1 1 1 PX domain XkdW PF09636.10 EKX73235.1 - 0.72 10.0 8.1 0.53 10.4 0.2 3.4 3 1 0 3 3 3 0 XkdW protein ATG16 PF08614.11 EKX73235.1 - 0.75 10.0 17.9 0.093 12.9 3.3 2.5 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) PEP-utilisers_N PF05524.13 EKX73235.1 - 0.8 9.9 2.5 1.6 9.0 0.2 2.6 2 1 1 3 3 3 0 PEP-utilising enzyme, N-terminal DUF1515 PF07439.11 EKX73235.1 - 1.5 8.9 5.3 20 5.3 0.9 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) APG6_N PF17675.1 EKX73235.1 - 1.7 9.2 12.3 1.4 9.5 0.6 2.7 2 0 0 2 2 2 0 Apg6 coiled-coil region DMPK_coil PF08826.10 EKX73235.1 - 7.5 6.7 6.4 15 5.8 0.6 3.0 2 0 0 2 2 2 0 DMPK coiled coil domain like Ham1p_like PF01725.16 EKX73236.1 - 1.1e-48 165.6 0.0 1.4e-48 165.3 0.0 1.0 1 0 0 1 1 1 1 Ham1 family Mitoc_mL59 PF18126.1 EKX73237.1 - 0.042 14.1 1.5 1.1 9.6 1.5 2.1 1 1 0 1 1 1 0 Mitochondrial ribosomal protein mL59 Glyco_transf_7N PF13733.6 EKX73238.1 - 0.00079 19.1 0.4 0.0014 18.3 0.4 1.4 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 FAST_1 PF06743.15 EKX73238.1 - 0.0061 16.5 0.3 0.0061 16.5 0.3 3.2 4 0 0 4 4 4 1 FAST kinase-like protein, subdomain 1 TAF PF02969.17 EKX73239.1 - 5.9e-08 32.8 0.3 2.2e-07 30.9 0.0 2.2 2 0 0 2 2 2 1 TATA box binding protein associated factor (TAF) TAF6_C PF07571.13 EKX73239.1 - 8.1e-06 26.1 0.1 6.1e-05 23.3 0.0 2.7 2 0 0 2 2 2 1 TAF6 C-terminal HEAT repeat domain Topoisom_bac PF01131.20 EKX73240.1 - 8.6e-110 367.6 0.0 1e-109 367.3 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 EKX73240.1 - 3.9e-17 62.3 0.0 1e-16 61.0 0.0 1.7 1 0 0 1 1 1 1 Toprim domain DUF1655 PF07868.11 EKX73240.1 - 0.029 14.4 0.0 4.4 7.4 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1655) Toprim_4 PF13662.6 EKX73240.1 - 0.055 13.9 0.0 0.33 11.4 0.0 2.1 2 0 0 2 2 2 0 Toprim domain EAP30 PF04157.16 EKX73240.1 - 0.072 12.4 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 EAP30/Vps36 family RRM_1 PF00076.22 EKX73241.1 - 4.3e-44 148.2 0.7 7.9e-18 64.0 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1866 PF08952.11 EKX73241.1 - 5.7e-07 29.5 0.1 0.0018 18.1 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF1866) Limkain-b1 PF11608.8 EKX73241.1 - 9.2e-06 25.7 0.6 1.4 9.1 0.0 3.9 4 0 0 4 4 4 2 Limkain b1 RRM_occluded PF16842.5 EKX73241.1 - 5.2e-05 23.0 0.1 2.2 8.2 0.0 3.5 3 0 0 3 3 3 2 Occluded RNA-recognition motif RBM39linker PF15519.6 EKX73241.1 - 0.0049 17.9 1.9 0.27 12.3 0.0 3.1 2 1 1 3 3 3 1 linker between RRM2 and RRM3 domains in RBM39 protein BRAP2 PF07576.12 EKX73241.1 - 0.025 14.8 0.1 22 5.3 0.0 3.2 3 0 0 3 3 3 0 BRCA1-associated protein 2 RRM_9 PF18444.1 EKX73241.1 - 0.1 12.4 1.0 0.73 9.7 0.1 2.6 3 0 0 3 3 3 0 RNA recognition motif DUF3707 PF12499.8 EKX73241.1 - 0.12 12.9 0.0 16 6.1 0.0 2.4 2 0 0 2 2 2 0 Pherophorin DUF1097 PF06496.11 EKX73242.1 - 0.06 13.5 6.0 0.069 13.3 3.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1097) DUF2157 PF09925.9 EKX73242.1 - 2.9 7.7 7.4 2.6 7.8 4.7 2.2 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) DUF3273 PF11677.8 EKX73243.1 - 1e-101 339.7 9.0 1.2e-101 339.5 9.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) Tom6 PF17112.5 EKX73243.1 - 5 6.7 6.0 9.1 5.9 0.7 2.6 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom6, fungal Vps52 PF04129.12 EKX73244.1 - 6e-37 127.6 22.1 9.5e-37 126.9 22.1 1.3 1 0 0 1 1 1 1 Vps52 / Sac2 family V-ATPase_G PF03179.15 EKX73245.1 - 3.5e-13 50.0 7.0 4.1e-13 49.8 7.0 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit ATP-synt_B PF00430.18 EKX73245.1 - 5.9e-06 26.4 5.2 7.3e-06 26.1 5.2 1.2 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) DUF2960 PF11173.8 EKX73245.1 - 0.0096 16.3 0.5 0.014 15.8 0.5 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2960) Mgr1 PF08602.10 EKX73245.1 - 0.046 12.6 1.6 0.048 12.5 1.6 1.0 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit DUF3301 PF11743.8 EKX73245.1 - 0.047 13.4 0.2 0.061 13.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3301) Acetyltransf_1 PF00583.25 EKX73246.1 - 8.9e-15 55.0 0.0 1.4e-14 54.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EKX73246.1 - 1.3e-07 32.0 0.1 2.1e-07 31.3 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EKX73246.1 - 1.1e-06 28.6 0.0 1.6e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EKX73246.1 - 0.00045 20.1 0.0 0.00076 19.4 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EKX73246.1 - 0.00096 19.2 0.0 0.0042 17.2 0.0 2.1 1 1 0 1 1 1 1 GCN5-related N-acetyl-transferase Ribosomal_L23 PF00276.20 EKX73247.1 - 1.2e-14 54.4 0.1 1.2e-14 54.4 0.1 2.7 2 2 0 2 2 2 1 Ribosomal protein L23 Ribosomal_L23eN PF03939.13 EKX73247.1 - 1.1e-06 28.8 10.6 2.4e-06 27.6 10.6 1.6 1 0 0 1 1 1 1 Ribosomal protein L23, N-terminal domain Aminotran_3 PF00202.21 EKX73247.1 - 0.15 10.7 0.4 0.16 10.6 0.4 1.1 1 0 0 1 1 1 0 Aminotransferase class-III Paf1 PF03985.13 EKX73248.1 - 3.9e-15 55.8 6.1 3.4e-09 36.2 0.5 2.9 3 0 0 3 3 3 2 Paf1 CHASE3 PF05227.13 EKX73248.1 - 0.17 11.8 0.9 0.33 10.9 0.9 1.4 1 0 0 1 1 1 0 CHASE3 domain DUF1461 PF07314.11 EKX73249.1 - 0.099 12.5 1.3 0.75 9.7 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1461) Got1 PF04178.12 EKX73250.1 - 9.2e-22 77.6 20.5 1.4e-21 77.0 20.5 1.3 1 0 0 1 1 1 1 Got1/Sft2-like family SAYSvFN PF10260.9 EKX73250.1 - 3 7.8 7.2 0.98 9.4 1.4 2.6 2 1 0 2 2 2 0 Uncharacterized conserved domain (SAYSvFN) Trypan_PARP PF05887.11 EKX73251.1 - 3e-05 24.0 7.0 4e-05 23.6 7.0 1.3 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Asp-B-Hydro_N PF05279.11 EKX73251.1 - 0.071 13.2 10.4 0.085 12.9 10.4 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Neur_chan_memb PF02932.16 EKX73251.1 - 0.15 12.1 0.4 0.2 11.7 0.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region NARP1 PF12569.8 EKX73251.1 - 0.32 9.9 5.0 0.35 9.7 5.0 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CDC45 PF02724.14 EKX73251.1 - 0.33 9.2 5.5 0.32 9.2 5.5 1.0 1 0 0 1 1 1 0 CDC45-like protein MAP17 PF15807.5 EKX73251.1 - 4.5 7.5 7.3 34 4.7 7.3 2.0 1 1 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 RCC1 PF00415.18 EKX73252.1 - 7.3e-46 154.6 0.6 9.9e-14 51.7 0.0 7.6 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EKX73252.1 - 1.6e-25 88.3 14.4 4.5e-08 32.7 1.1 6.9 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat Vps36-NZF-N PF16988.5 EKX73252.1 - 0.018 14.4 3.9 0.045 13.1 3.9 1.7 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain DZR PF12773.7 EKX73252.1 - 0.039 14.0 3.6 0.097 12.7 3.6 1.6 1 0 0 1 1 1 0 Double zinc ribbon zf-RanBP PF00641.18 EKX73252.1 - 0.06 12.7 8.1 0.15 11.4 8.1 1.6 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others eIF2A PF08662.11 EKX73252.1 - 0.12 12.2 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A TAXi_N PF14543.6 EKX73253.1 - 4.6e-22 79.1 5.0 2.1e-21 76.9 5.0 2.1 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp PF00026.23 EKX73253.1 - 1e-15 58.0 4.7 6.7e-15 55.3 4.7 2.2 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 EKX73253.1 - 2.5e-06 27.4 0.0 0.0011 18.8 0.0 2.4 2 0 0 2 2 2 2 Xylanase inhibitor C-terminal RNA_POL_M_15KD PF02150.16 EKX73253.1 - 0.3 11.0 2.8 0.39 10.6 0.8 2.4 2 1 1 3 3 3 0 RNA polymerases M/15 Kd subunit UCH PF00443.29 EKX73254.1 - 2.4e-32 112.5 2.7 5.7e-32 111.2 2.7 1.7 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EKX73254.1 - 2.7e-12 47.0 8.8 2.9e-06 27.1 0.3 3.5 2 1 1 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase LYTB PF02401.18 EKX73255.1 - 1.9e-79 266.7 0.9 2.2e-79 266.5 0.9 1.0 1 0 0 1 1 1 1 LytB protein Ribosomal_S2 PF00318.20 EKX73255.1 - 0.026 13.8 0.3 0.32 10.2 0.1 2.3 1 1 2 3 3 3 0 Ribosomal protein S2 DUF3228 PF11539.8 EKX73256.1 - 1.1e-80 269.8 0.1 1.6e-80 269.2 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3228) Pyr_redox_2 PF07992.14 EKX73257.1 - 1.5e-50 172.1 0.2 2.1e-50 171.6 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EKX73257.1 - 3.9e-16 59.4 0.3 3.5e-13 49.9 0.2 3.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.26 EKX73257.1 - 2.2e-13 50.0 0.7 1.4e-12 47.3 0.1 2.4 2 0 0 2 2 2 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 EKX73257.1 - 8.5e-06 25.7 0.0 4e-05 23.5 0.0 2.1 2 0 0 2 2 2 1 Rieske-like [2Fe-2S] domain Pyr_redox_3 PF13738.6 EKX73257.1 - 1.4e-05 24.5 0.1 0.14 11.3 0.0 2.3 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Reductase_C PF14759.6 EKX73257.1 - 2.1e-05 25.0 0.0 0.00019 21.9 0.0 2.4 2 0 0 2 2 2 1 Reductase C-terminal NAD_binding_7 PF13241.6 EKX73257.1 - 0.004 17.6 0.1 1.3 9.6 0.1 2.6 3 0 0 3 3 3 1 Putative NAD(P)-binding Lycopene_cycl PF05834.12 EKX73257.1 - 0.0041 16.2 2.2 7.3 5.5 0.0 3.5 2 2 2 4 4 4 2 Lycopene cyclase protein TrkA_N PF02254.18 EKX73257.1 - 0.006 16.8 0.0 3.9 7.8 0.0 3.0 3 0 0 3 3 3 1 TrkA-N domain Rhodanese PF00581.20 EKX73257.1 - 0.032 14.7 0.0 0.55 10.8 0.0 2.5 2 0 0 2 2 2 0 Rhodanese-like domain NAD_binding_8 PF13450.6 EKX73257.1 - 0.045 14.0 0.5 2.5 8.4 0.2 2.7 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EKX73257.1 - 0.09 12.8 0.2 0.81 9.7 0.0 2.5 3 0 0 3 3 3 0 FAD-NAD(P)-binding HI0933_like PF03486.14 EKX73257.1 - 0.11 11.2 1.2 1.1 7.9 0.0 2.8 3 1 1 4 4 4 0 HI0933-like protein DUF1344 PF07076.11 EKX73257.1 - 0.17 11.9 2.2 0.29 11.1 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1344) Chorein_N PF12624.7 EKX73258.1 - 2.2e-28 98.7 0.3 1.7e-27 95.9 0.1 2.7 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 SHR-BD PF06650.12 EKX73258.1 - 2.5e-09 36.9 2.2 5.2e-09 35.9 0.2 2.4 2 0 0 2 2 2 1 SHR-binding domain of vacuolar-sorting associated protein 13 ATG_C PF09333.11 EKX73258.1 - 3.2e-07 30.6 0.0 7.8e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain VPS13 PF16908.5 EKX73258.1 - 3.6e-05 23.7 2.4 0.00013 21.9 2.4 2.0 1 0 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal DEAD PF00270.29 EKX73259.1 - 2.2e-16 60.1 0.1 9e-16 58.1 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EKX73259.1 - 7e-10 39.2 0.0 7.4e-09 35.8 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EKX73259.1 - 0.00067 20.0 0.2 0.0043 17.4 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain GldM_N PF12081.8 EKX73259.1 - 0.82 9.7 8.4 70 3.4 7.0 3.1 3 0 0 3 3 3 0 GldM N-terminal domain Ras PF00071.22 EKX73260.1 - 1.1e-56 190.9 0.4 1.4e-56 190.6 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKX73260.1 - 3.1e-34 117.8 0.1 4.6e-34 117.2 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKX73260.1 - 9.1e-13 48.0 0.0 1e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKX73260.1 - 3.2e-08 33.7 0.0 4.8e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EKX73260.1 - 1.7e-05 24.3 0.1 2e-05 24.1 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EKX73260.1 - 7e-05 22.5 0.2 0.0036 16.9 0.2 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EKX73260.1 - 0.00023 20.6 0.0 0.00034 20.1 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Septin PF00735.18 EKX73260.1 - 0.00087 18.7 0.1 0.0023 17.3 0.0 1.6 2 0 0 2 2 2 1 Septin RsgA_GTPase PF03193.16 EKX73260.1 - 0.00091 19.2 0.2 0.0034 17.3 0.1 1.9 1 1 2 3 3 3 1 RsgA GTPase G-alpha PF00503.20 EKX73260.1 - 0.001 18.3 2.1 0.029 13.5 0.1 2.3 1 1 1 2 2 2 1 G-protein alpha subunit AAA_16 PF13191.6 EKX73260.1 - 0.002 18.5 0.0 0.0025 18.2 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain ATP_bind_1 PF03029.17 EKX73260.1 - 0.0038 17.0 0.3 0.18 11.6 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein ATPase_2 PF01637.18 EKX73260.1 - 0.0051 16.8 0.1 0.0052 16.7 0.1 1.4 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EKX73260.1 - 0.0095 15.7 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 EKX73260.1 - 0.015 14.9 0.1 0.031 13.9 0.0 1.5 1 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EKX73260.1 - 0.018 15.0 0.0 0.04 13.8 0.0 1.6 2 0 0 2 2 2 0 NACHT domain AAA_22 PF13401.6 EKX73260.1 - 0.019 15.2 0.0 0.037 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EKX73260.1 - 0.026 14.0 0.0 0.048 13.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 EKX73260.1 - 0.03 13.7 0.0 0.049 13.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein RNA_helicase PF00910.22 EKX73260.1 - 0.038 14.4 0.1 0.098 13.1 0.0 1.8 2 1 0 2 2 1 0 RNA helicase NTPase_1 PF03266.15 EKX73260.1 - 0.045 13.7 0.0 0.073 13.0 0.0 1.4 1 0 0 1 1 1 0 NTPase PduV-EutP PF10662.9 EKX73260.1 - 0.046 13.5 0.2 0.076 12.8 0.2 1.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 EKX73260.1 - 0.047 14.2 0.4 0.064 13.8 0.4 1.6 1 1 0 1 1 1 0 ABC transporter AIG1 PF04548.16 EKX73260.1 - 0.077 12.3 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 AIG1 family AAA_14 PF13173.6 EKX73260.1 - 0.088 12.8 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EKX73260.1 - 0.11 11.7 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain DAP3 PF10236.9 EKX73260.1 - 0.12 11.5 0.0 0.21 10.7 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 FeoB_N PF02421.18 EKX73260.1 - 0.13 11.8 0.1 0.44 10.1 0.0 1.9 2 0 0 2 2 2 0 Ferrous iron transport protein B MCM PF00493.23 EKX73260.1 - 0.14 11.2 0.0 0.24 10.5 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain Rer1 PF03248.13 EKX73261.1 - 9.9e-58 194.6 10.7 1.3e-57 194.3 10.7 1.1 1 0 0 1 1 1 1 Rer1 family Cullin PF00888.22 EKX73263.1 - 2.1e-45 155.5 32.7 7.7e-45 153.6 32.7 1.8 1 1 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EKX73263.1 - 1.7e-05 24.8 1.4 3.3e-05 23.8 0.1 2.2 2 0 0 2 2 2 1 Cullin protein neddylation domain DOT1 PF08123.13 EKX73264.1 - 0.0024 17.4 0.0 0.0058 16.2 0.0 1.7 1 0 0 1 1 1 1 Histone methylation protein DOT1 PCMT PF01135.19 EKX73264.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) zf-RanBP PF00641.18 EKX73265.1 - 2.3e-06 26.8 1.8 4.8e-06 25.8 1.8 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Zip PF02535.22 EKX73265.1 - 0.09 12.0 6.0 0.099 11.8 6.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 EKX73265.1 - 0.59 8.8 5.2 0.65 8.7 5.2 1.1 1 0 0 1 1 1 0 Presenilin OrfB_IS605 PF01385.19 EKX73265.1 - 0.96 9.7 6.9 0.45 10.8 3.5 2.0 2 0 0 2 2 2 0 Probable transposase zf-XS PF03470.14 EKX73266.1 - 0.056 13.7 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 XS zinc finger domain Steroid_dh PF02544.16 EKX73267.1 - 2e-31 109.0 15.5 2e-31 109.0 15.5 1.5 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase LAX PF15681.5 EKX73267.1 - 0.2 10.4 0.5 0.29 9.9 0.5 1.1 1 0 0 1 1 1 0 Lymphocyte activation family X Alba PF01918.21 EKX73268.1 - 8.3e-17 60.8 0.1 1.2e-16 60.3 0.1 1.3 1 0 0 1 1 1 1 Alba IF3_C PF00707.22 EKX73268.1 - 0.13 12.2 0.0 0.22 11.5 0.0 1.4 1 1 0 1 1 1 0 Translation initiation factor IF-3, C-terminal domain ATP_synt_H PF05493.13 EKX73269.1 - 5.9e-13 49.1 5.1 8.5e-13 48.6 5.1 1.2 1 0 0 1 1 1 1 ATP synthase subunit H DUF4149 PF13664.6 EKX73269.1 - 0.011 16.1 2.6 0.014 15.7 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4149) Ammonium_transp PF00909.21 EKX73269.1 - 0.028 13.1 0.3 0.031 13.0 0.3 1.0 1 0 0 1 1 1 0 Ammonium Transporter Family DUF4131 PF13567.6 EKX73269.1 - 0.029 14.0 1.1 0.034 13.8 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Viral_Beta_CD PF04530.12 EKX73269.1 - 0.13 12.5 2.4 0.22 11.8 0.1 1.9 1 1 1 2 2 2 0 Viral Beta C/D like family TMEM213 PF15192.6 EKX73269.1 - 0.15 12.1 0.2 0.15 12.1 0.2 1.8 1 1 1 2 2 2 0 TMEM213 family AAA_12 PF13087.6 EKX73270.1 - 6.3e-54 182.6 0.0 2.9e-53 180.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EKX73270.1 - 1.1e-39 136.8 0.1 5.6e-24 85.3 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_19 PF13245.6 EKX73270.1 - 1.3e-10 41.8 0.0 3.8e-10 40.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EKX73270.1 - 5e-09 36.2 0.0 1.9e-08 34.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain PhoH PF02562.16 EKX73270.1 - 1.5e-06 27.8 0.0 0.028 13.9 0.0 2.6 2 0 0 2 2 2 2 PhoH-like protein ResIII PF04851.15 EKX73270.1 - 3.4e-06 27.1 0.0 9.8e-06 25.7 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 EKX73270.1 - 0.00037 19.9 0.1 0.048 12.9 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 EKX73270.1 - 0.0012 18.8 0.0 0.0077 16.2 0.0 2.3 2 0 0 2 2 2 1 NACHT domain ATPase PF06745.13 EKX73270.1 - 0.0034 16.8 0.1 2.2 7.6 0.0 2.4 2 0 0 2 2 2 2 KaiC IstB_IS21 PF01695.17 EKX73270.1 - 0.0035 17.1 0.0 0.0092 15.7 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein PIF1 PF05970.14 EKX73270.1 - 0.0048 16.1 0.1 0.98 8.5 0.0 3.1 3 0 0 3 3 3 1 PIF1-like helicase UvrD-helicase PF00580.21 EKX73270.1 - 0.021 14.4 1.7 0.1 12.1 0.0 2.8 2 2 1 3 3 3 0 UvrD/REP helicase N-terminal domain AAA PF00004.29 EKX73270.1 - 0.022 15.2 0.0 0.056 13.9 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) dsrm PF00035.26 EKX73270.1 - 0.026 15.2 0.6 20 6.0 0.1 3.6 3 0 0 3 3 3 0 Double-stranded RNA binding motif Nbas_N PF15492.6 EKX73270.1 - 0.037 13.4 0.0 0.062 12.6 0.0 1.2 1 0 0 1 1 1 0 Neuroblastoma-amplified sequence, N terminal AAA_16 PF13191.6 EKX73270.1 - 0.096 13.1 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EKX73270.1 - 0.12 12.7 0.0 0.89 9.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain Ribosomal_S18 PF01084.20 EKX73271.1 - 0.0098 16.1 0.9 0.052 13.8 0.6 2.0 1 1 1 2 2 2 1 Ribosomal protein S18 SH2_2 PF14633.6 EKX73273.1 - 2e-20 73.1 0.6 7e-20 71.4 0.0 2.3 2 0 0 2 2 2 1 SH2 domain HHH_7 PF14635.6 EKX73273.1 - 4.9e-18 65.4 0.2 2.5e-17 63.1 0.1 2.3 2 0 0 2 2 2 1 Helix-hairpin-helix motif HTH_44 PF14641.6 EKX73273.1 - 9.6e-08 32.5 1.2 3.3e-07 30.7 1.2 1.9 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 RRM_1 PF00076.22 EKX73274.1 - 8.1e-17 60.8 0.0 1e-16 60.5 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EKX73274.1 - 1.9e-06 27.8 0.0 2.6e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 RNA binding motif RRM_5 PF13893.6 EKX73274.1 - 0.00014 21.5 0.0 0.00018 21.1 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EKX73274.1 - 0.028 14.3 0.0 0.051 13.4 0.0 1.4 1 1 0 1 1 1 0 Occluded RNA-recognition motif Limkain-b1 PF11608.8 EKX73274.1 - 0.11 12.6 0.0 0.25 11.4 0.0 1.7 1 1 0 1 1 1 0 Limkain b1 HTH_38 PF13936.6 EKX73275.1 - 0.051 13.4 0.3 0.14 12.0 0.3 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain bZIP_1 PF00170.21 EKX73275.1 - 0.38 10.9 16.7 0.2 11.8 6.1 2.9 2 0 0 2 2 2 0 bZIP transcription factor ZapB PF06005.12 EKX73275.1 - 6.7 7.2 18.1 1.3 9.5 4.0 3.3 3 1 0 3 3 3 0 Cell division protein ZapB MOZART1 PF12554.8 EKX73276.1 - 4.6e-17 61.5 0.3 6e-17 61.2 0.3 1.1 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated NPV_P10 PF05531.12 EKX73277.1 - 0.03 14.8 1.8 0.03 14.8 1.8 4.7 3 2 2 5 5 5 0 Nucleopolyhedrovirus P10 protein KASH_CCD PF14662.6 EKX73277.1 - 0.075 12.9 39.6 0.055 13.3 1.7 3.4 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH DUF4259 PF14078.6 EKX73277.1 - 0.44 11.3 4.1 1.1 10.0 4.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4259) CENP-Q PF13094.6 EKX73277.1 - 3.2 7.9 28.9 5.2 7.3 18.9 2.5 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit ZapB PF06005.12 EKX73277.1 - 4.3 7.8 42.1 0.13 12.7 1.7 5.7 4 1 1 6 6 6 0 Cell division protein ZapB ATG16 PF08614.11 EKX73277.1 - 5.7 7.1 34.5 7.2 6.8 31.2 2.9 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Img2 PF05046.14 EKX73279.1 - 1e-15 57.8 0.4 1.5e-15 57.3 0.4 1.2 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) EF-hand_7 PF13499.6 EKX73281.1 - 6.3e-26 90.6 1.2 2.1e-15 56.9 0.8 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EKX73281.1 - 1.1e-23 81.0 4.8 3.6e-07 29.3 0.0 4.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EKX73281.1 - 4.3e-21 73.0 3.3 6.6e-08 31.9 0.0 3.9 4 1 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 EKX73281.1 - 1.1e-18 66.8 5.9 7.2e-11 41.8 0.3 3.6 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EKX73281.1 - 9.2e-11 40.7 5.3 0.00015 21.1 0.3 3.5 3 0 0 3 3 3 2 EF hand EF-hand_9 PF14658.6 EKX73281.1 - 1.3e-07 31.8 0.0 2.3e-05 24.6 0.0 2.6 3 0 0 3 3 3 1 EF-hand domain EF-hand_14 PF17959.1 EKX73281.1 - 1e-05 25.8 0.3 0.18 12.2 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EKX73281.1 - 0.0013 18.6 0.5 0.038 14.0 0.2 2.6 1 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_11 PF08976.11 EKX73281.1 - 0.014 16.3 0.2 0.27 12.1 0.1 2.3 1 1 1 2 2 2 0 EF-hand domain SUB1_ProdP9 PF18213.1 EKX73281.1 - 0.015 15.1 0.1 0.035 14.0 0.1 1.6 1 0 0 1 1 1 0 SUB1 protease Prodomain ProdP9 PMBR PF09373.10 EKX73281.1 - 0.17 12.1 0.1 19 5.7 0.0 3.8 5 0 0 5 5 5 0 Pseudomurein-binding repeat DUF3458_C PF17432.2 EKX73283.1 - 0.036 13.4 0.1 2 7.7 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3458_C) ARM repeats HTH_10 PF04967.12 EKX73285.1 - 0.11 12.3 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 HTH DNA binding domain Ribosomal_L28e PF01778.17 EKX73286.1 - 9.9e-20 71.4 0.3 1.1e-19 71.2 0.3 1.0 1 0 0 1 1 1 1 Ribosomal L28e protein family Hydrolase_4 PF12146.8 EKX73287.1 - 9.2e-23 80.7 0.0 6.6e-22 77.9 0.0 2.2 2 1 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX73287.1 - 2.7e-18 65.8 4.5 7.1e-06 26.0 0.0 4.7 4 0 0 4 4 4 3 Domain of unknown function, DUF529 Abhydrolase_1 PF00561.20 EKX73287.1 - 0.016 14.9 0.1 0.066 12.8 0.1 2.1 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EKX73287.1 - 0.02 15.5 0.0 0.042 14.4 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 EKX73287.1 - 0.14 12.0 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold ABC_tran PF00005.27 EKX73290.1 - 8e-32 110.6 0.0 2.2e-17 63.9 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_29 PF13555.6 EKX73290.1 - 0.0001 22.0 2.1 0.058 13.2 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EKX73290.1 - 0.00011 22.2 0.4 0.13 12.2 0.1 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 EKX73290.1 - 0.00012 22.0 1.4 0.17 11.6 0.0 3.3 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 EKX73290.1 - 0.00012 21.8 0.1 0.34 10.6 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EKX73290.1 - 0.00012 22.5 0.0 0.078 13.4 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 EKX73290.1 - 0.0002 21.9 5.9 0.095 13.2 1.1 2.6 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 EKX73290.1 - 0.00093 18.5 0.2 0.74 9.1 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin MMR_HSR1 PF01926.23 EKX73290.1 - 0.002 18.2 0.2 0.21 11.7 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EKX73290.1 - 0.0036 17.6 0.0 1.1 9.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain DnaB_C PF03796.15 EKX73290.1 - 0.0048 16.3 0.0 0.47 9.7 0.0 2.2 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_18 PF13238.6 EKX73290.1 - 0.01 16.4 0.1 2.4 8.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EKX73290.1 - 0.017 14.8 0.1 0.86 9.3 0.0 3.1 3 0 0 3 3 3 0 IstB-like ATP binding protein MeaB PF03308.16 EKX73290.1 - 0.02 13.9 0.4 0.071 12.1 0.0 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB FtsK_SpoIIIE PF01580.18 EKX73290.1 - 0.038 13.3 0.4 5.1 6.4 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family SMC_N PF02463.19 EKX73290.1 - 0.048 13.1 0.6 0.74 9.2 0.0 2.4 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain cobW PF02492.19 EKX73290.1 - 0.078 12.6 0.9 8.1 6.0 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.17 EKX73290.1 - 0.08 13.0 2.8 0.18 11.9 0.1 2.6 3 0 0 3 3 2 0 Helicase HerA, central domain ATPase_2 PF01637.18 EKX73290.1 - 0.11 12.4 0.2 15 5.4 0.0 2.8 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea SbcCD_C PF13558.6 EKX73290.1 - 0.12 12.7 0.0 0.28 11.5 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit NACHT PF05729.12 EKX73290.1 - 0.18 11.7 0.6 18 5.2 0.0 2.6 2 0 0 2 2 2 0 NACHT domain TsaE PF02367.17 EKX73290.1 - 0.23 11.5 0.5 4.3 7.4 0.1 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE T2SSE PF00437.20 EKX73290.1 - 0.24 10.4 1.0 9.8 5.1 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_15 PF13175.6 EKX73290.1 - 0.25 11.0 1.8 1.8 8.2 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain DUF116 PF01976.17 EKX73291.1 - 0.17 11.4 0.1 0.27 10.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF116 Vasculin PF15337.6 EKX73291.1 - 0.31 11.9 2.5 0.82 10.5 0.1 2.7 3 0 0 3 3 3 0 Vascular protein family Vasculin-like 1 Tfb5 PF06331.12 EKX73293.1 - 5.6e-10 39.1 0.1 7.1e-10 38.7 0.1 1.1 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 FAINT PF04385.15 EKX73294.1 - 7.9e-12 45.1 5.5 8.9e-06 25.7 1.7 2.8 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Tektin PF03148.14 EKX73294.1 - 0.0016 17.3 0.3 0.0039 16.0 0.3 1.6 1 0 0 1 1 1 1 Tektin family TMP_2 PF06791.13 EKX73294.1 - 0.043 13.5 1.3 0.091 12.4 1.3 1.5 1 0 0 1 1 1 0 Prophage tail length tape measure protein SesA PF17107.5 EKX73294.1 - 0.093 12.9 3.3 3.1 8.0 4.0 2.6 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases ATP-synt_DE PF00401.20 EKX73294.1 - 0.67 10.3 2.1 1.7 9.0 0.3 2.3 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain DUF4175 PF13779.6 EKX73294.1 - 1.1 7.1 8.2 0.18 9.6 4.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4175) MIT PF04212.18 EKX73295.1 - 0.012 15.7 2.1 0.026 14.6 0.2 2.5 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 EKX73295.1 - 0.042 13.5 1.9 0.11 12.3 0.3 2.3 2 0 0 2 2 2 0 TPR repeat Phage-tail_1 PF09097.10 EKX73295.1 - 0.097 12.5 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Baseplate structural protein, domain 1 Hydrolase_4 PF12146.8 EKX73297.1 - 7.4e-17 61.4 0.0 4.7e-16 58.8 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX73297.1 - 5.9e-13 48.7 6.0 3e-05 24.0 0.0 5.1 5 0 0 5 5 5 3 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73298.1 - 1.3e-22 79.7 24.4 0.0093 16.0 0.0 9.6 8 2 1 9 9 9 8 Domain of unknown function, DUF529 CBM_1 PF00734.18 EKX73298.1 - 0.2 11.6 1.6 0.77 9.8 1.6 2.0 1 0 0 1 1 1 0 Fungal cellulose binding domain PolyA_pol PF01743.20 EKX73301.1 - 2.1e-27 96.0 0.0 3.6e-27 95.3 0.0 1.4 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EKX73301.1 - 0.00045 19.9 0.0 0.00096 18.9 0.0 1.6 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A DDRGK PF09756.9 EKX73302.1 - 7.9e-47 159.3 25.5 1.1e-46 158.8 25.5 1.2 1 0 0 1 1 1 1 DDRGK domain PA26 PF04636.13 EKX73302.1 - 0.0043 16.0 5.3 0.0049 15.9 5.3 1.1 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) SID-1_RNA_chan PF13965.6 EKX73302.1 - 0.016 13.7 4.0 0.02 13.3 4.0 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Zip PF02535.22 EKX73302.1 - 0.043 13.0 1.7 0.05 12.8 1.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NAGLU PF05089.12 EKX73302.1 - 0.076 12.0 0.1 0.11 11.5 0.1 1.3 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain V_ATPase_I PF01496.19 EKX73302.1 - 0.12 10.2 8.6 0.13 10.1 8.6 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Atg14 PF10186.9 EKX73302.1 - 0.14 11.2 12.8 0.17 10.9 12.8 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Neur_chan_memb PF02932.16 EKX73302.1 - 0.16 12.0 2.1 0.23 11.5 2.1 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region UPF0242 PF06785.11 EKX73302.1 - 0.16 12.0 18.8 0.053 13.6 15.9 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus SAGA-Tad1 PF12767.7 EKX73302.1 - 0.18 11.5 8.5 0.29 10.8 8.5 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF4407 PF14362.6 EKX73302.1 - 0.22 10.8 10.0 0.32 10.3 10.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Borrelia_P83 PF05262.11 EKX73302.1 - 1.1 7.7 20.6 1.3 7.4 20.6 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein MAP17 PF15807.5 EKX73302.1 - 2.1 8.6 16.5 0.03 14.6 4.0 2.2 1 1 1 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 PRP1_N PF06424.12 EKX73302.1 - 2.4 8.5 16.4 4.4 7.7 16.4 1.3 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal O-antigen_lig PF13425.6 EKX73302.1 - 2.8 6.6 6.4 4.2 6.0 6.4 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Helicase_C_2 PF13307.6 EKX73303.1 - 1e-29 103.9 0.0 1.3e-29 103.6 0.0 1.1 1 0 0 1 1 1 1 Helicase C-terminal domain DUF3093 PF11292.8 EKX73304.1 - 2.5 8.4 5.6 3.7 7.8 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3093) FAINT PF04385.15 EKX73305.1 - 0.00055 20.0 1.7 0.00091 19.2 0.0 2.3 2 1 0 2 2 2 1 Domain of unknown function, DUF529 Dyp_perox PF04261.12 EKX73305.1 - 0.0038 16.3 0.0 0.0063 15.6 0.0 1.3 1 0 0 1 1 1 1 Dyp-type peroxidase family DUF4355 PF14265.6 EKX73305.1 - 0.094 13.0 0.2 0.094 13.0 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) PRELI PF04707.14 EKX73306.1 - 4.6e-21 75.3 0.2 5.4e-21 75.0 0.2 1.0 1 0 0 1 1 1 1 PRELI-like family Med1 PF10744.9 EKX73306.1 - 0.039 13.0 0.0 0.06 12.4 0.0 1.2 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription subunit 1 Sde2_N_Ubi PF13019.6 EKX73307.1 - 7.6e-15 55.1 0.3 1.1e-14 54.6 0.3 1.3 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain Armet PF10208.9 EKX73308.1 - 0.0062 16.5 3.7 0.0081 16.1 0.3 2.7 1 1 2 3 3 3 1 Degradation arginine-rich protein for mis-folding BACK PF07707.15 EKX73309.1 - 0.00023 21.2 0.1 0.00081 19.4 0.0 2.0 2 1 0 2 2 2 1 BTB And C-terminal Kelch ESCRT-II PF05871.12 EKX73310.1 - 8e-12 45.6 0.0 2.3e-11 44.1 0.0 1.9 1 1 0 1 1 1 1 ESCRT-II complex subunit FH2 PF02181.23 EKX73310.1 - 0.0083 15.3 0.1 0.011 14.9 0.1 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain Prenyltrans PF00432.21 EKX73311.1 - 1.3e-38 130.4 5.5 4.4e-09 35.9 0.0 5.2 5 0 0 5 5 5 4 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 EKX73311.1 - 5.3e-06 25.7 0.0 0.82 8.7 0.0 4.0 1 1 4 5 5 5 5 Squalene-hopene cyclase N-terminal domain CDC27 PF09507.10 EKX73312.1 - 0.03 13.7 41.2 0.014 14.8 38.6 1.5 1 1 1 2 2 2 0 DNA polymerase subunit Cdc27 MMR_HSR1 PF01926.23 EKX73313.1 - 1.6e-47 160.3 0.6 8.6e-24 83.8 0.0 2.5 3 0 0 3 3 2 2 50S ribosome-binding GTPase KH_dom-like PF14714.6 EKX73313.1 - 2e-24 85.7 0.0 7.1e-24 83.9 0.0 2.0 1 1 0 1 1 1 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal FeoB_N PF02421.18 EKX73313.1 - 2.3e-23 82.5 0.1 4.9e-12 45.7 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.27 EKX73313.1 - 1.5e-17 63.8 0.7 1.7e-10 40.8 0.1 4.2 2 2 0 2 2 2 2 Elongation factor Tu GTP binding domain Ras PF00071.22 EKX73313.1 - 9.4e-14 51.3 0.1 9.3e-08 31.8 0.0 2.4 2 1 0 2 2 2 2 Ras family Dynamin_N PF00350.23 EKX73313.1 - 2.3e-13 50.6 0.5 0.0064 16.6 0.0 4.4 2 2 2 4 4 4 3 Dynamin family AIG1 PF04548.16 EKX73313.1 - 3.7e-13 49.3 1.8 2.1e-06 27.2 0.3 3.2 3 1 0 3 3 3 2 AIG1 family Roc PF08477.13 EKX73313.1 - 5.2e-12 46.0 0.1 0.00017 21.7 0.0 2.8 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EKX73313.1 - 8.8e-10 38.7 1.3 0.0074 16.2 0.1 3.8 2 1 1 3 3 3 3 RsgA GTPase SRPRB PF09439.10 EKX73313.1 - 2.9e-09 36.6 0.4 0.0015 18.0 0.3 2.5 2 1 0 2 2 2 2 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EKX73313.1 - 6.9e-09 35.4 0.6 0.00014 21.3 0.0 2.1 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 EKX73313.1 - 2e-07 30.8 0.1 0.017 14.9 0.0 2.9 2 2 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation AAA_15 PF13175.6 EKX73313.1 - 1.4e-05 25.0 0.4 0.053 13.2 0.0 2.5 2 1 0 2 2 2 2 AAA ATPase domain ABC_tran PF00005.27 EKX73313.1 - 2e-05 25.1 0.1 0.32 11.5 0.0 2.8 2 1 0 2 2 2 2 ABC transporter Arf PF00025.21 EKX73313.1 - 9.3e-05 21.9 0.4 0.0015 18.0 0.1 2.3 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_22 PF13401.6 EKX73313.1 - 0.00038 20.7 0.0 0.016 15.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EKX73313.1 - 0.0018 17.5 0.0 0.37 9.9 0.0 2.4 2 0 0 2 2 2 1 NB-ARC domain TniB PF05621.11 EKX73313.1 - 0.0021 17.5 0.3 1.3 8.4 0.0 2.7 3 1 0 3 3 3 1 Bacterial TniB protein MMR_HSR1_Xtn PF16897.5 EKX73313.1 - 0.0057 16.7 1.3 0.55 10.3 0.5 2.6 2 1 0 2 2 2 1 C-terminal region of MMR_HSR1 domain AAA_16 PF13191.6 EKX73313.1 - 0.0065 16.9 0.0 4.5 7.6 0.0 2.5 1 1 0 2 2 2 1 AAA ATPase domain MeaB PF03308.16 EKX73313.1 - 0.0075 15.3 0.1 5.7 5.8 0.0 3.4 3 1 1 4 4 4 1 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 EKX73313.1 - 0.015 15.6 0.0 6.1 7.3 0.0 2.8 2 0 0 2 2 2 0 RNA helicase AAA PF00004.29 EKX73313.1 - 0.02 15.3 0.0 2.3 8.7 0.0 2.7 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TIR_2 PF13676.6 EKX73313.1 - 0.078 13.6 0.2 8.4 7.0 0.1 2.3 2 0 0 2 2 2 0 TIR domain MCM PF00493.23 EKX73313.1 - 0.079 12.0 0.0 4.1 6.4 0.0 2.3 2 0 0 2 2 2 0 MCM P-loop domain cobW PF02492.19 EKX73313.1 - 0.082 12.5 1.3 0.81 9.2 0.1 2.9 2 2 3 5 5 5 0 CobW/HypB/UreG, nucleotide-binding domain NOG1 PF06858.14 EKX73313.1 - 1.4 8.8 4.4 1.7 8.5 0.1 3.1 3 1 0 3 3 3 0 Nucleolar GTP-binding protein 1 (NOG1) zf-CSL PF05207.13 EKX73314.1 - 1.9e-18 65.9 2.8 2.6e-18 65.5 2.8 1.2 1 0 0 1 1 1 1 CSL zinc finger YGGT PF02325.17 EKX73315.1 - 7.3e-12 45.5 1.9 9.7e-12 45.1 1.9 1.2 1 0 0 1 1 1 1 YGGT family FAINT PF04385.15 EKX73316.1 - 1.1e-05 25.4 0.1 2.2e-05 24.4 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function, DUF529 ABC_tran PF00005.27 EKX73317.1 - 5.1e-33 114.5 0.0 7.3e-18 65.4 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_29 PF13555.6 EKX73317.1 - 5.3e-06 26.1 0.8 0.11 12.2 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_30 PF13604.6 EKX73317.1 - 5e-05 23.1 0.2 0.022 14.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EKX73317.1 - 7.7e-05 23.1 0.0 0.086 13.2 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 EKX73317.1 - 8.9e-05 22.4 2.2 0.04 13.7 0.3 2.9 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EKX73317.1 - 9.2e-05 22.4 0.6 0.092 12.7 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 EKX73317.1 - 0.00011 22.8 2.3 0.45 11.0 0.7 2.5 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 EKX73317.1 - 0.00052 20.1 0.4 0.21 11.7 0.1 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase Zeta_toxin PF06414.12 EKX73317.1 - 0.00075 18.8 0.3 0.36 10.1 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin DUF87 PF01935.17 EKX73317.1 - 0.0019 18.3 2.0 0.05 13.7 0.1 2.6 2 0 0 2 2 2 1 Helicase HerA, central domain DnaB_C PF03796.15 EKX73317.1 - 0.0028 17.0 0.1 0.59 9.4 0.0 2.3 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain SMC_N PF02463.19 EKX73317.1 - 0.0036 16.8 2.1 0.047 13.1 0.4 2.5 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain FtsK_SpoIIIE PF01580.18 EKX73317.1 - 0.0068 15.8 2.3 1.2 8.4 0.1 2.6 3 0 0 3 3 3 2 FtsK/SpoIIIE family Dynamin_N PF00350.23 EKX73317.1 - 0.0077 16.3 0.3 0.5 10.4 0.0 2.5 2 0 0 2 2 2 1 Dynamin family MeaB PF03308.16 EKX73317.1 - 0.0082 15.1 0.4 0.069 12.1 0.1 2.0 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Fer4_NifH PF00142.18 EKX73317.1 - 0.012 15.1 0.1 3.8 6.9 0.0 2.3 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_15 PF13175.6 EKX73317.1 - 0.03 14.1 1.0 2.8 7.6 0.2 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 EKX73317.1 - 0.039 14.2 0.1 6.1 7.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.14 EKX73317.1 - 0.042 13.1 0.0 1.5 8.0 0.0 2.2 2 0 0 2 2 2 0 KAP family P-loop domain SbcCD_C PF13558.6 EKX73317.1 - 0.047 13.9 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_27 PF13514.6 EKX73317.1 - 0.064 12.8 0.2 8.6 5.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EKX73317.1 - 0.1 13.0 0.1 17 5.9 0.0 3.1 3 0 0 3 3 2 0 RNA helicase NB-ARC PF00931.22 EKX73317.1 - 0.12 11.5 0.8 1.5 8.0 0.1 2.7 3 0 0 3 3 3 0 NB-ARC domain AAA_18 PF13238.6 EKX73317.1 - 0.14 12.7 4.0 7 7.2 0.0 2.8 3 0 0 3 3 2 0 AAA domain TrwB_AAD_bind PF10412.9 EKX73317.1 - 0.15 11.0 2.0 5.6 5.8 0.1 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_25 PF13481.6 EKX73317.1 - 0.17 11.5 0.0 3.4 7.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EKX73317.1 - 0.19 11.3 0.6 10 5.6 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FAINT PF04385.15 EKX73318.1 - 1.8e-12 47.1 5.5 4.3e-07 29.9 0.4 2.9 2 0 0 2 2 2 2 Domain of unknown function, DUF529 SAC3_GANP PF03399.16 EKX73319.1 - 1.3e-11 44.4 15.4 2.4e-09 37.0 15.4 3.0 1 1 0 1 1 1 1 SAC3/GANP family Methyltransf_29 PF03141.16 EKX73319.1 - 0.084 11.4 0.1 0.13 10.8 0.1 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Helicase_C_2 PF13307.6 EKX73320.1 - 4.8e-38 131.0 0.0 1.5e-37 129.4 0.0 1.9 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 EKX73320.1 - 9.6e-38 129.6 1.6 2.5e-37 128.2 1.6 1.8 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.15 EKX73320.1 - 1.7e-05 24.9 0.0 0.012 15.6 0.0 3.0 2 1 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.29 EKX73320.1 - 0.0007 19.4 0.0 0.014 15.1 0.0 2.5 1 1 0 1 1 1 1 DEAD/DEAH box helicase HBB PF06777.11 EKX73320.1 - 0.0045 16.7 2.2 0.011 15.4 0.0 2.6 3 0 0 3 3 3 1 Helical and beta-bridge domain SNF2_N PF00176.23 EKX73320.1 - 0.023 13.4 0.0 0.054 12.2 0.0 1.6 1 0 0 1 1 1 0 SNF2 family N-terminal domain FAINT PF04385.15 EKX73322.1 - 2.6e-09 37.0 0.0 0.016 15.2 0.0 4.0 4 0 0 4 4 4 3 Domain of unknown function, DUF529 HMG_box PF00505.19 EKX73322.1 - 0.23 11.9 0.9 2.2 8.8 0.6 2.7 3 0 0 3 3 3 0 HMG (high mobility group) box RVT_1 PF00078.27 EKX73323.1 - 8.6e-08 32.0 0.1 2.3e-07 30.6 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) IPK PF03770.16 EKX73324.1 - 2.6e-20 73.1 0.3 6.6e-20 71.8 0.3 1.7 1 1 0 1 1 1 1 Inositol polyphosphate kinase Rib_5-P_isom_A PF06026.14 EKX73325.1 - 1.3e-42 145.4 0.0 1.9e-42 144.8 0.0 1.2 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) Synaptobrevin PF00957.21 EKX73326.1 - 4.1e-08 32.9 5.2 6.3e-08 32.3 1.0 2.1 1 1 1 2 2 2 1 Synaptobrevin BLOC1_2 PF10046.9 EKX73326.1 - 0.0048 17.2 5.6 0.19 12.0 1.9 2.2 1 1 1 2 2 2 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF725 PF05267.12 EKX73326.1 - 0.017 15.1 1.3 0.053 13.5 1.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF725) TBCC_N PF16752.5 EKX73326.1 - 0.018 15.4 1.7 0.036 14.5 1.6 1.6 1 1 0 1 1 1 0 Tubulin-specific chaperone C N-terminal domain Laminin_II PF06009.12 EKX73326.1 - 0.05 13.6 7.2 0.67 10.0 7.2 2.0 1 1 0 1 1 1 0 Laminin Domain II DUF4803 PF16061.5 EKX73326.1 - 0.068 12.6 0.2 0.092 12.2 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4803) Fzo_mitofusin PF04799.13 EKX73326.1 - 0.071 12.7 2.5 0.53 9.8 0.1 2.1 2 0 0 2 2 2 0 fzo-like conserved region CorA PF01544.18 EKX73326.1 - 0.074 12.4 3.6 0.13 11.5 3.5 1.4 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF745 PF05335.13 EKX73326.1 - 0.075 12.7 2.7 0.82 9.4 0.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Rx_N PF18052.1 EKX73326.1 - 0.081 13.2 5.4 1.5 9.1 0.6 2.2 1 1 1 2 2 2 0 Rx N-terminal domain RPW8 PF05659.11 EKX73326.1 - 0.12 12.1 2.6 0.53 10.0 0.3 2.1 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DASH_Ask1 PF08655.10 EKX73326.1 - 0.12 12.2 0.5 1.1 9.2 0.2 2.4 2 0 0 2 2 2 0 DASH complex subunit Ask1 DUF1664 PF07889.12 EKX73326.1 - 0.13 12.3 4.5 1.8 8.6 0.3 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Sec20 PF03908.13 EKX73326.1 - 0.14 12.1 1.3 0.95 9.4 0.2 2.2 1 1 0 2 2 2 0 Sec20 WXG100 PF06013.12 EKX73326.1 - 0.15 12.4 1.7 2.7 8.3 0.5 2.6 1 1 0 2 2 2 0 Proteins of 100 residues with WXG DASH_Dam1 PF08653.10 EKX73326.1 - 0.26 11.1 1.7 2.8 7.8 0.4 2.4 2 0 0 2 2 2 0 DASH complex subunit Dam1 DUF2721 PF11026.8 EKX73326.1 - 0.41 10.5 1.9 4.5 7.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) MtrG PF04210.13 EKX73326.1 - 0.44 10.4 1.6 1.3 8.9 0.2 2.4 2 1 1 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G H-kinase_dim PF02895.14 EKX73326.1 - 0.59 10.6 5.6 7 7.1 0.2 2.6 2 1 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain CTP_transf_like PF01467.26 EKX73327.1 - 1e-14 55.0 0.0 1.4e-14 54.5 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like CS PF04969.16 EKX73329.1 - 6.4e-07 30.3 0.6 1e-06 29.7 0.6 1.3 1 0 0 1 1 1 1 CS domain SGS PF05002.15 EKX73329.1 - 0.00059 19.9 0.2 0.0012 18.9 0.2 1.5 1 0 0 1 1 1 1 SGS domain Siah-Interact_N PF09032.11 EKX73329.1 - 0.012 15.9 0.0 0.031 14.6 0.0 1.7 1 0 0 1 1 1 0 Siah interacting protein, N terminal E3_UFM1_ligase PF09743.9 EKX73330.1 - 8.3e-43 147.0 0.3 1.9e-42 145.8 0.3 1.5 1 0 0 1 1 1 1 E3 UFM1-protein ligase 1 EnY2 PF10163.9 EKX73330.1 - 0.029 14.8 0.1 2.3 8.7 0.0 3.5 3 1 2 5 5 5 0 Transcription factor e(y)2 Pept_S41_N PF18294.1 EKX73330.1 - 0.061 13.3 0.2 0.14 12.2 0.2 1.6 1 0 0 1 1 1 0 Peptidase S41 N-terminal domain DUF3924 PF13062.6 EKX73330.1 - 0.15 12.0 0.3 0.61 10.1 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3924) CAP_N PF01213.19 EKX73330.1 - 2.8 7.4 8.7 6.1 6.2 8.7 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal FAINT PF04385.15 EKX73332.1 - 3.9e-06 26.8 0.1 0.046 13.8 0.0 3.1 2 1 1 3 3 3 2 Domain of unknown function, DUF529 CAV_VP3 PF04771.12 EKX73332.1 - 0.16 12.1 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 Chicken anaemia virus VP-3 protein FAINT PF04385.15 EKX73333.1 - 0.052 13.6 0.0 0.083 13.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function, DUF529 ETRAMP PF09716.10 EKX73333.1 - 0.057 13.5 0.1 0.069 13.2 0.1 1.4 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) VSP PF03302.13 EKX73334.1 - 0.017 14.0 0.1 0.035 13.0 0.1 1.4 1 0 0 1 1 1 0 Giardia variant-specific surface protein FAINT PF04385.15 EKX73335.1 - 0.00035 20.6 0.2 0.00048 20.1 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function, DUF529 DUF948 PF06103.11 EKX73336.1 - 1e-06 28.9 3.5 0.031 14.5 0.0 3.8 3 2 1 4 4 4 2 Bacterial protein of unknown function (DUF948) ApoLp-III PF07464.11 EKX73336.1 - 0.00013 22.1 4.1 0.036 14.2 0.2 3.1 3 0 0 3 3 3 2 Apolipophorin-III precursor (apoLp-III) LXG PF04740.12 EKX73336.1 - 0.0026 17.5 3.4 0.94 9.2 0.2 2.6 2 0 0 2 2 2 2 LXG domain of WXG superfamily Clusterin PF01093.17 EKX73336.1 - 0.008 15.3 3.7 0.01 14.9 0.6 2.1 1 1 1 2 2 2 1 Clusterin Syntaxin_2 PF14523.6 EKX73336.1 - 0.081 13.3 8.0 1 9.8 0.3 3.2 2 2 0 2 2 2 0 Syntaxin-like protein Yuri_gagarin PF15934.5 EKX73336.1 - 0.3 10.9 7.4 0.04 13.8 1.8 2.1 2 0 0 2 2 2 0 Yuri gagarin RHSP PF07999.11 EKX73336.1 - 0.56 8.9 3.6 0.31 9.8 1.0 1.7 2 0 0 2 2 2 0 Retrotransposon hot spot protein DUF643 PF04867.12 EKX73336.1 - 1.2 9.8 7.9 1.4 9.6 4.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF643) DUF3395 PF11875.8 EKX73339.1 - 4.7e-25 88.3 0.0 8.8e-25 87.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 EKX73339.1 - 2.4e-15 56.4 0.0 6e-15 55.1 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain HAT PF02184.16 EKX73339.1 - 0.058 13.4 1.1 4.4 7.3 0.1 2.4 2 0 0 2 2 2 0 HAT (Half-A-TPR) repeat Bromo_TP PF07524.13 EKX73340.1 - 0.0011 18.9 0.0 0.002 18.1 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated FAINT PF04385.15 EKX73341.1 - 1.7e-05 24.8 2.1 0.0021 18.1 0.0 3.1 3 0 0 3 3 3 2 Domain of unknown function, DUF529 Ribosomal_L6e PF01159.19 EKX73341.1 - 0.03 14.9 1.4 0.048 14.2 1.4 1.3 1 0 0 1 1 1 0 Ribosomal protein L6e HTH_Tnp_4 PF13613.6 EKX73341.1 - 0.13 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease FAINT PF04385.15 EKX73342.1 - 7.9e-15 54.7 5.1 2.2e-07 30.9 0.9 2.6 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73344.1 - 2.9e-19 68.9 6.1 6.7e-10 38.9 2.8 2.3 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Peptidase_U49 PF10463.9 EKX73344.1 - 0.076 12.8 0.3 0.14 11.9 0.3 1.4 1 0 0 1 1 1 0 Peptidase U49 IL6Ra-bind PF09240.10 EKX73344.1 - 0.1 13.0 0.2 1.3 9.5 0.0 2.4 2 1 0 2 2 2 0 Interleukin-6 receptor alpha chain, binding DHHC PF01529.20 EKX73345.1 - 2.8e-33 114.9 13.2 2.8e-33 114.9 13.2 2.3 2 1 0 2 2 2 1 DHHC palmitoyltransferase Pox_A14 PF05767.12 EKX73345.1 - 1.4 9.1 9.4 1.5 9.1 1.5 2.6 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 DUF2207 PF09972.9 EKX73345.1 - 2.7 6.6 5.7 4.5 5.9 0.9 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Inhibitor_I42 PF09394.10 EKX73346.1 - 0.079 13.4 1.4 1.3 9.5 0.0 3.1 3 0 0 3 3 3 0 Chagasin family peptidase inhibitor I42 DUF2341 PF10102.9 EKX73346.1 - 3.2 8.4 5.0 24 5.6 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF2341) ubiquitin PF00240.23 EKX73347.1 - 0.0029 17.3 0.0 0.0029 17.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family Med31 PF05669.12 EKX73348.1 - 7.5e-33 112.4 4.4 1e-32 111.9 4.4 1.2 1 0 0 1 1 1 1 SOH1 Plus-3 PF03126.18 EKX73351.1 - 0.051 14.1 0.0 0.83 10.2 0.0 2.6 2 1 0 2 2 2 0 Plus-3 domain EMG1 PF03587.14 EKX73352.1 - 1.9e-13 50.5 0.2 2.8e-13 49.9 0.1 1.3 2 0 0 2 2 2 1 EMG1/NEP1 methyltransferase Na_trans_assoc PF06512.13 EKX73352.1 - 0.015 15.6 5.4 0.019 15.2 5.4 1.1 1 0 0 1 1 1 0 Sodium ion transport-associated Myc_N PF01056.18 EKX73352.1 - 0.024 14.6 4.4 0.029 14.3 4.4 1.1 1 0 0 1 1 1 0 Myc amino-terminal region FAM176 PF14851.6 EKX73352.1 - 0.029 14.0 4.0 0.056 13.1 4.0 1.5 1 0 0 1 1 1 0 FAM176 family TLP-20 PF06088.11 EKX73352.1 - 0.33 10.8 6.5 0.47 10.3 6.5 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) YL1 PF05764.13 EKX73352.1 - 0.82 9.7 16.7 1.3 9.1 16.3 1.4 1 1 1 2 2 2 0 YL1 nuclear protein DUF1676 PF07898.13 EKX73352.1 - 0.92 9.5 3.8 1.4 9.0 3.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1676) GOLD_2 PF13897.6 EKX73352.1 - 4.8 7.7 6.8 2.9 8.4 4.5 1.6 1 1 1 2 2 2 0 Golgi-dynamics membrane-trafficking AltA1 PF16541.5 EKX73353.1 - 0.0058 17.5 2.8 0.28 12.1 0.3 3.9 3 0 0 3 3 3 1 Alternaria alternata allergen 1 PRA-CH PF01502.18 EKX73353.1 - 0.068 13.0 0.1 0.25 11.2 0.1 1.9 1 0 0 1 1 1 0 Phosphoribosyl-AMP cyclohydrolase rRNA_processing PF08524.11 EKX73354.1 - 3.7e-10 40.0 24.4 3.7e-10 40.0 24.4 2.1 1 1 1 2 2 2 1 rRNA processing RNA_GG_bind PF10258.9 EKX73354.1 - 0.023 14.7 5.8 0.028 14.5 2.5 2.5 2 1 0 2 2 2 0 PHAX RNA-binding domain CDC45 PF02724.14 EKX73354.1 - 5.4 5.2 15.6 6.1 5.0 15.6 1.1 1 0 0 1 1 1 0 CDC45-like protein eIF3_subunit PF08597.10 EKX73354.1 - 7 6.5 19.6 0.76 9.6 15.1 1.6 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit Plasmid_parti PF01672.16 EKX73355.1 - 0.11 13.1 0.0 0.41 11.3 0.0 2.0 2 0 0 2 2 2 0 Putative plasmid partition protein Zn_Tnp_IS1595 PF12760.7 EKX73355.1 - 7.6 6.6 8.0 6 6.9 0.6 2.3 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Fcf1 PF04900.12 EKX73356.1 - 3.3e-24 85.1 0.1 1.5e-22 79.9 0.0 2.1 2 0 0 2 2 2 1 Fcf1 MNE1 PF13762.6 EKX73356.1 - 0.0045 17.0 0.1 0.0089 16.0 0.1 1.5 2 0 0 2 2 2 1 Mitochondrial splicing apparatus component HBD PF18534.1 EKX73356.1 - 0.13 12.4 0.1 22 5.3 0.0 2.3 2 0 0 2 2 2 0 Helical bundle domain SLBP_RNA_bind PF15247.6 EKX73357.1 - 0.22 11.7 2.0 1.8 8.8 0.0 3.1 2 0 0 2 2 2 0 Histone RNA hairpin-binding protein RNA-binding domain ANAPC4_WD40 PF12894.7 EKX73359.1 - 6.6e-07 29.5 0.1 0.00018 21.8 0.0 3.2 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EKX73359.1 - 3.6e-05 24.4 12.0 0.32 11.9 1.0 5.2 6 1 0 6 6 6 2 WD domain, G-beta repeat WD40_like PF17005.5 EKX73359.1 - 0.033 13.5 0.0 0.061 12.7 0.0 1.4 1 0 0 1 1 1 0 WD40-like domain NPV_P10 PF05531.12 EKX73360.1 - 0.086 13.3 0.5 0.27 11.7 0.5 1.8 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF3829 PF12889.7 EKX73360.1 - 0.33 10.4 11.6 0.86 9.0 10.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3829) Peptidase_S55 PF05580.12 EKX73360.1 - 0.81 9.6 5.7 1.1 9.1 5.7 1.2 1 0 0 1 1 1 0 SpoIVB peptidase S55 Ribosomal_S8e PF01201.22 EKX73360.1 - 1.8 8.8 9.5 2.8 8.1 9.5 1.3 1 0 0 1 1 1 0 Ribosomal protein S8e Noggin PF05806.12 EKX73360.1 - 4.7 7.1 9.0 0.73 9.7 4.8 1.7 1 1 1 2 2 2 0 Noggin ABC_tran PF00005.27 EKX73361.1 - 5e-32 111.3 0.0 6e-17 62.4 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EKX73361.1 - 1.5e-06 28.3 1.4 0.041 13.7 0.3 3.1 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EKX73361.1 - 4.3e-06 26.4 1.0 0.12 12.2 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_membrane PF00664.23 EKX73361.1 - 5e-06 26.4 18.6 5e-06 26.4 18.6 3.3 3 0 0 3 3 3 1 ABC transporter transmembrane region AAA_16 PF13191.6 EKX73361.1 - 3.8e-05 24.1 0.0 0.021 15.2 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EKX73361.1 - 6.8e-05 22.8 0.6 0.057 13.3 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase MeaB PF03308.16 EKX73361.1 - 0.00011 21.3 0.4 0.0011 18.0 0.0 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 EKX73361.1 - 0.00012 21.9 0.1 0.062 13.0 0.0 2.3 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 EKX73361.1 - 0.00033 20.0 0.4 0.22 10.8 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin MMR_HSR1 PF01926.23 EKX73361.1 - 0.00087 19.4 0.3 0.21 11.7 0.1 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EKX73361.1 - 0.0031 17.6 0.6 0.44 10.6 0.0 2.5 2 0 0 2 2 2 1 Dynamin family AAA_23 PF13476.6 EKX73361.1 - 0.0034 17.9 4.2 0.66 10.4 1.2 2.4 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EKX73361.1 - 0.0035 17.9 0.3 2.2 8.9 0.1 2.6 2 0 0 2 2 2 1 AAA domain DnaB_C PF03796.15 EKX73361.1 - 0.0043 16.4 0.0 0.082 12.2 0.0 2.2 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain FtsK_SpoIIIE PF01580.18 EKX73361.1 - 0.0085 15.5 0.4 1.2 8.4 0.1 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family DUF87 PF01935.17 EKX73361.1 - 0.0097 16.0 4.8 0.051 13.7 0.3 2.6 3 0 0 3 3 2 1 Helicase HerA, central domain SMC_N PF02463.19 EKX73361.1 - 0.011 15.2 1.9 0.063 12.7 0.3 2.5 2 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EKX73361.1 - 0.015 15.6 0.2 1.8 8.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 EKX73361.1 - 0.041 13.6 1.5 3 7.5 0.3 2.3 2 0 0 2 2 2 0 AAA ATPase domain T2SSE PF00437.20 EKX73361.1 - 0.069 12.2 0.7 4.7 6.2 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein NB-ARC PF00931.22 EKX73361.1 - 0.088 12.0 0.4 1.1 8.3 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain DUF815 PF05673.13 EKX73361.1 - 0.098 11.8 0.8 2.3 7.3 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF815) ATP_bind_1 PF03029.17 EKX73361.1 - 0.11 12.3 0.1 4.9 6.9 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein NACHT PF05729.12 EKX73361.1 - 0.11 12.4 0.8 18 5.2 0.1 2.6 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.6 EKX73361.1 - 0.14 11.8 0.1 3.1 7.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.7 EKX73361.1 - 0.15 11.0 0.1 13 4.6 0.1 2.2 2 0 0 2 2 2 0 AAA-like domain TrwB_AAD_bind PF10412.9 EKX73361.1 - 0.15 10.9 0.5 8.5 5.2 0.1 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain SbcCD_C PF13558.6 EKX73361.1 - 0.18 12.1 0.0 0.41 10.9 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit CrgA PF06781.12 EKX73361.1 - 5.7 7.1 5.8 4.7 7.3 0.0 3.3 4 0 0 4 4 3 0 Cell division protein CrgA FAINT PF04385.15 EKX73362.1 - 9.6e-73 240.3 83.2 5.3e-05 23.2 2.1 21.3 21 0 0 21 21 21 18 Domain of unknown function, DUF529 Viral_P18 PF04521.13 EKX73362.1 - 0.0044 16.8 0.0 0.015 15.1 0.0 1.9 2 0 0 2 2 2 1 ssRNA positive strand viral 18kD cysteine rich protein DUF4362 PF14275.6 EKX73362.1 - 0.074 13.3 0.2 2.2 8.6 0.1 3.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4362) MHCassoc_trimer PF08831.10 EKX73363.1 - 0.039 14.0 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 Class II MHC-associated invariant chain trimerisation domain MatE PF01554.18 EKX73364.1 - 0.00039 20.1 0.6 0.059 13.0 0.0 2.2 2 0 0 2 2 2 2 MatE DUF4131 PF13567.6 EKX73364.1 - 0.4 10.3 3.2 7.2 6.2 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF4149 PF13664.6 EKX73364.1 - 6.8 7.1 11.0 2.1e+02 2.3 11.0 3.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4149) RFC1 PF08519.12 EKX73365.1 - 2.6e-33 115.4 0.1 5.7e-33 114.3 0.1 1.6 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain AAA PF00004.29 EKX73365.1 - 1.2e-11 45.1 0.0 3e-11 43.9 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BRCT PF00533.26 EKX73365.1 - 1.2e-07 32.0 0.1 3.7e-07 30.4 0.1 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Rad17 PF03215.15 EKX73365.1 - 0.00075 19.5 0.3 0.02 14.8 0.3 2.6 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 EKX73365.1 - 0.0026 18.2 0.0 0.0086 16.5 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EKX73365.1 - 0.0031 17.8 0.2 0.032 14.5 0.1 2.7 2 1 0 2 2 2 1 AAA domain AAA_2 PF07724.14 EKX73365.1 - 0.0048 17.0 0.0 0.013 15.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Zeta_toxin PF06414.12 EKX73365.1 - 0.0061 15.9 0.0 0.016 14.5 0.0 1.7 1 0 0 1 1 1 1 Zeta toxin DNA_pol3_delta PF06144.13 EKX73365.1 - 0.0097 15.7 0.0 0.027 14.2 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase III, delta subunit RuvB_N PF05496.12 EKX73365.1 - 0.011 15.5 0.0 0.038 13.7 0.0 1.8 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 EKX73365.1 - 0.019 15.0 0.0 0.043 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EKX73365.1 - 0.041 14.2 0.0 0.091 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 EKX73365.1 - 0.056 13.9 0.2 0.31 11.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EKX73365.1 - 0.063 13.3 0.0 0.18 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 EKX73365.1 - 0.071 13.4 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain FAINT PF04385.15 EKX73367.1 - 1e-07 31.9 0.0 1.3e-07 31.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73370.1 - 5.1e-10 39.3 2.5 0.00052 20.0 0.6 2.5 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Hydrolase_4 PF12146.8 EKX73373.1 - 4.3e-22 78.6 0.0 2.2e-21 76.3 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EKX73373.1 - 2.3e-07 30.8 0.9 8.6e-06 25.6 0.9 2.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold FAINT PF04385.15 EKX73373.1 - 1.7e-05 24.8 8.9 0.0098 15.9 1.6 4.3 3 0 0 3 3 3 2 Domain of unknown function, DUF529 Abhydrolase_6 PF12697.7 EKX73373.1 - 3.3e-05 24.6 0.0 5.9e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EKX73373.1 - 0.0032 17.0 0.1 3.5 7.0 0.0 3.0 3 0 0 3 3 3 2 Prolyl oligopeptidase family DUF900 PF05990.12 EKX73373.1 - 0.012 15.2 0.0 0.021 14.3 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) LIDHydrolase PF10230.9 EKX73373.1 - 0.036 13.6 0.1 0.092 12.3 0.1 1.6 1 1 0 1 1 1 0 Lipid-droplet associated hydrolase DUF676 PF05057.14 EKX73373.1 - 0.041 13.4 0.0 0.55 9.7 0.0 2.2 2 0 0 2 2 2 0 Putative serine esterase (DUF676) Abhydrolase_3 PF07859.13 EKX73373.1 - 0.077 12.8 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.13 EKX73373.1 - 0.11 12.1 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein FAINT PF04385.15 EKX73374.1 - 0.0037 17.3 1.2 0.0072 16.4 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function, DUF529 Collagen PF01391.18 EKX73375.1 - 0.068 12.9 13.8 0.22 11.3 13.8 1.8 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Ribosomal_S30 PF04758.14 EKX73377.1 - 1.6e-25 89.0 9.7 1.8e-25 88.9 9.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 Sec1 PF00995.23 EKX73378.1 - 7.7e-97 325.9 4.8 8.9e-97 325.7 4.8 1.0 1 0 0 1 1 1 1 Sec1 family Sugar_tr PF00083.24 EKX73379.1 - 0.14 10.9 0.0 0.18 10.7 0.0 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter DIRP PF06584.13 EKX73379.1 - 1.3 9.2 5.3 6.8 6.9 1.0 2.3 1 1 0 2 2 2 0 DIRP FAINT PF04385.15 EKX73381.1 - 8e-13 48.3 3.6 2.1e-05 24.5 0.1 2.8 3 0 0 3 3 3 2 Domain of unknown function, DUF529 AviRa PF11599.8 EKX73381.1 - 0.048 13.1 0.0 0.071 12.6 0.0 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa AF0941-like PF14591.6 EKX73382.1 - 0.029 14.9 1.9 0.029 14.9 1.9 3.5 3 1 0 3 3 3 0 AF0941-like TMPIT PF07851.13 EKX73382.1 - 0.31 10.2 5.7 0.58 9.4 0.1 2.3 2 0 0 2 2 2 0 TMPIT-like protein DUF948 PF06103.11 EKX73382.1 - 0.57 10.5 6.8 54 4.2 0.0 4.6 3 2 2 5 5 5 0 Bacterial protein of unknown function (DUF948) Fib_alpha PF08702.10 EKX73382.1 - 3.1 8.0 12.5 2.6 8.2 5.3 2.9 2 2 0 2 2 2 0 Fibrinogen alpha/beta chain family 7TMR-HDED PF07697.11 EKX73382.1 - 5.6 7.0 13.4 15 5.6 12.0 2.0 1 1 1 2 2 2 0 7TM-HD extracellular FAINT PF04385.15 EKX73383.1 - 0.00019 21.4 0.0 0.00036 20.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73384.1 - 2.8e-30 104.2 8.5 4.6e-07 29.8 0.0 6.1 5 0 0 5 5 5 5 Domain of unknown function, DUF529 DUF3093 PF11292.8 EKX73386.1 - 2.3 8.5 5.4 3.7 7.8 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3093) PALB2_WD40 PF16756.5 EKX73388.1 - 0.12 11.3 0.0 0.15 11.0 0.0 1.1 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain ATP-synt_ab PF00006.25 EKX73389.1 - 4.7e-72 242.1 0.0 6.9e-72 241.6 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 EKX73389.1 - 1.3e-44 151.5 0.3 2.2e-44 150.8 0.3 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 EKX73389.1 - 1.3e-15 57.6 2.0 4.5e-15 55.9 2.0 2.0 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.10 EKX73389.1 - 0.0018 18.4 0.6 0.0039 17.3 0.6 1.5 1 0 0 1 1 1 1 HAS barrel domain AAA_16 PF13191.6 EKX73389.1 - 0.028 14.8 0.2 3.2 8.1 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain CSD PF00313.22 EKX73390.1 - 4.3e-23 80.9 0.1 5.6e-23 80.6 0.1 1.2 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 EKX73390.1 - 0.0016 18.1 0.2 0.0045 16.6 0.1 1.8 1 1 1 2 2 2 1 Ribonuclease B OB domain S1 PF00575.23 EKX73390.1 - 0.0045 17.3 0.2 0.0063 16.8 0.2 1.2 1 0 0 1 1 1 1 S1 RNA binding domain Sin3_corepress PF08295.12 EKX73390.1 - 0.087 12.9 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Sin3 family co-repressor A2M PF00207.22 EKX73390.1 - 0.17 11.7 0.0 0.21 11.5 0.0 1.2 1 0 0 1 1 1 0 Alpha-2-macroglobulin family CECR6_TMEM121 PF14997.6 EKX73391.1 - 8.9e-15 55.0 8.6 8.9e-15 55.0 8.6 2.9 3 1 0 3 3 3 1 CECR6/TMEM121 family ABC_tran PF00005.27 EKX73392.1 - 2.6e-30 105.7 0.0 9e-17 61.9 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_30 PF13604.6 EKX73392.1 - 6.9e-06 25.9 0.6 0.0031 17.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EKX73392.1 - 1.8e-05 25.2 0.0 0.022 15.1 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EKX73392.1 - 6.3e-05 22.6 1.1 0.15 11.8 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EKX73392.1 - 0.00017 21.5 0.4 0.22 11.3 0.1 3.4 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EKX73392.1 - 0.0005 20.0 1.2 0.037 13.9 0.2 2.3 2 0 0 2 2 2 1 RsgA GTPase DnaB_C PF03796.15 EKX73392.1 - 0.00062 19.2 0.0 0.14 11.5 0.0 2.2 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain Zeta_toxin PF06414.12 EKX73392.1 - 0.00091 18.6 0.4 0.2 10.9 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_23 PF13476.6 EKX73392.1 - 0.001 19.6 5.0 0.5 10.8 0.4 2.8 3 0 0 3 3 2 2 AAA domain AAA_18 PF13238.6 EKX73392.1 - 0.0022 18.5 0.2 3.3 8.2 0.1 2.7 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 EKX73392.1 - 0.004 17.3 3.2 0.048 13.8 0.2 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain SMC_N PF02463.19 EKX73392.1 - 0.0042 16.6 0.3 0.18 11.2 0.0 2.5 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain MeaB PF03308.16 EKX73392.1 - 0.0045 16.0 1.3 0.0052 15.8 0.1 1.6 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Fer4_NifH PF00142.18 EKX73392.1 - 0.0051 16.3 0.3 0.94 8.9 0.0 2.2 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family FtsK_SpoIIIE PF01580.18 EKX73392.1 - 0.0074 15.7 1.2 1.7 7.9 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family MMR_HSR1 PF01926.23 EKX73392.1 - 0.0093 16.0 0.4 0.23 11.5 0.1 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase T2SSE PF00437.20 EKX73392.1 - 0.019 14.0 2.0 3.3 6.7 0.0 2.8 3 0 0 3 3 3 0 Type II/IV secretion system protein DUF2791 PF10923.8 EKX73392.1 - 0.022 13.6 0.0 0.28 10.0 0.0 2.1 2 0 0 2 2 2 0 P-loop Domain of unknown function (DUF2791) AAA_22 PF13401.6 EKX73392.1 - 0.025 14.8 0.0 4.9 7.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 EKX73392.1 - 0.037 13.6 0.7 0.54 9.8 0.0 2.7 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain SbcCD_C PF13558.6 EKX73392.1 - 0.05 13.8 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 EKX73392.1 - 0.054 13.2 0.4 5 6.7 0.1 2.3 2 0 0 2 2 2 0 AAA ATPase domain cobW PF02492.19 EKX73392.1 - 0.062 12.9 0.7 9.6 5.8 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.17 EKX73392.1 - 0.074 12.8 0.5 3.9 7.2 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_25 PF13481.6 EKX73392.1 - 0.1 12.2 0.0 2.5 7.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EKX73392.1 - 0.11 12.4 1.4 3 7.8 0.1 2.4 2 0 0 2 2 2 0 NACHT domain Sigma54_activat PF00158.26 EKX73392.1 - 0.14 11.8 0.2 5.2 6.7 0.1 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain TrwB_AAD_bind PF10412.9 EKX73392.1 - 0.15 10.9 1.7 9.5 5.0 0.4 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain IstB_IS21 PF01695.17 EKX73392.1 - 0.16 11.7 0.1 5.3 6.7 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein Dynamin_N PF00350.23 EKX73392.1 - 0.18 11.9 0.4 9 6.3 0.0 2.4 2 0 0 2 2 2 0 Dynamin family AAA_33 PF13671.6 EKX73392.1 - 0.19 11.9 0.1 27 4.9 0.1 2.6 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EKX73392.1 - 0.19 11.6 1.3 8.2 6.3 0.1 2.4 2 0 0 2 2 2 0 NTPase TsaE PF02367.17 EKX73392.1 - 0.21 11.6 1.0 4 7.5 0.1 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 EKX73392.1 - 0.29 10.3 3.5 0.8 8.8 0.1 2.6 3 0 0 3 3 2 0 NB-ARC domain SMK-1 PF04802.15 EKX73395.1 - 2.4e-23 83.0 7.1 5e-23 81.9 5.1 2.2 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 Glyco_hydro_20b PF02838.15 EKX73395.1 - 0.19 12.5 0.0 0.42 11.4 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 20, domain 2 DNA_pol_E_B PF04042.16 EKX73396.1 - 4.6e-28 98.0 0.4 6.7e-28 97.5 0.4 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B BING4CT PF08149.11 EKX73397.1 - 6e-32 109.3 0.0 3.2e-30 103.8 0.0 2.7 2 0 0 2 2 2 1 BING4CT (NUC141) domain WD40 PF00400.32 EKX73397.1 - 0.00035 21.3 3.1 0.57 11.2 0.1 4.0 4 0 0 4 4 4 2 WD domain, G-beta repeat TBCC_N PF16752.5 EKX73397.1 - 0.23 11.9 4.0 0.53 10.7 4.0 1.5 1 0 0 1 1 1 0 Tubulin-specific chaperone C N-terminal domain Cwf_Cwc_15 PF04889.12 EKX73398.1 - 1.5e-42 146.1 22.3 1.4e-39 136.3 22.3 2.2 1 1 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein MFAP1 PF06991.11 EKX73398.1 - 0.0077 16.1 13.7 0.011 15.7 13.7 1.2 1 0 0 1 1 1 1 Microfibril-associated/Pre-mRNA processing DUF3295 PF11702.8 EKX73398.1 - 0.03 13.7 8.2 0.036 13.4 7.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3295) AAA_23 PF13476.6 EKX73398.1 - 0.94 9.9 11.7 1.3 9.5 11.7 1.2 1 0 0 1 1 1 0 AAA domain YchF-GTPase_C PF06071.13 EKX73399.1 - 8.5e-40 134.8 0.1 2.2e-39 133.5 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EKX73399.1 - 1.6e-20 73.3 0.0 7.6e-20 71.1 0.0 2.1 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EKX73399.1 - 9.7e-06 25.2 0.0 2.5e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA PF00004.29 EKX73399.1 - 0.0043 17.5 0.1 0.017 15.6 0.0 2.0 2 1 1 3 3 3 1 ATPase family associated with various cellular activities (AAA) Dynamin_N PF00350.23 EKX73399.1 - 0.058 13.4 0.3 6.5 6.8 0.0 3.1 2 1 1 3 3 3 0 Dynamin family ABC_tran PF00005.27 EKX73399.1 - 0.12 12.8 0.0 2.3 8.7 0.0 2.2 2 0 0 2 2 2 0 ABC transporter NuA4 PF09340.10 EKX73400.1 - 3.1e-06 27.0 0.1 1.2e-05 25.1 0.1 2.1 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 Stm1_N PF09598.10 EKX73400.1 - 8.3 7.3 7.7 5.2 8.0 1.7 2.6 2 0 0 2 2 2 0 Stm1 Cmc1 PF08583.10 EKX73401.1 - 2.8e-11 43.2 6.0 3.2e-11 43.1 6.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like NDUF_B7 PF05676.13 EKX73401.1 - 0.002 17.8 1.3 0.0027 17.4 1.3 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) IL4Ra_N PF09238.10 EKX73401.1 - 0.02 15.2 0.9 0.023 15.0 0.9 1.1 1 0 0 1 1 1 0 Interleukin-4 receptor alpha chain, N-terminal CX9C PF16860.5 EKX73401.1 - 0.027 14.5 4.2 0.031 14.3 3.3 1.6 1 1 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 EKX73401.1 - 0.089 13.0 2.5 0.33 11.1 2.5 1.9 1 1 1 2 2 2 0 CHCH domain Phage_holin_3_3 PF16083.5 EKX73402.1 - 0.13 12.4 4.8 1.6 8.9 0.2 3.8 4 0 0 4 4 4 0 LydA holin phage, holin superfamily III zf-Mss51 PF13824.6 EKX73404.1 - 7.4e-06 26.0 2.8 1.9e-05 24.7 2.8 1.7 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-MYND PF01753.18 EKX73404.1 - 2.6e-05 24.2 7.7 2.6e-05 24.2 7.7 1.9 2 0 0 2 2 2 1 MYND finger Piwi PF02171.17 EKX73404.1 - 0.0046 16.2 0.0 0.0094 15.2 0.0 1.5 1 0 0 1 1 1 1 Piwi domain zf-HIT PF04438.16 EKX73404.1 - 0.24 11.3 6.6 0.65 9.9 6.6 1.8 1 0 0 1 1 1 0 HIT zinc finger zf-C6H2 PF15801.5 EKX73404.1 - 1.7 9.0 10.5 0.93 9.8 8.0 2.0 2 0 0 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding MRP-S25 PF13741.6 EKX73405.1 - 0.00038 20.1 1.5 0.016 14.7 0.3 2.2 1 1 1 2 2 2 2 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 EKX73405.1 - 0.086 13.1 0.4 0.32 11.3 0.4 2.0 1 1 0 1 1 1 0 Mitochondrial ribosomal protein S23 TGT PF01702.18 EKX73406.1 - 8.8e-25 87.6 0.0 6e-24 84.8 0.0 1.9 1 1 0 1 1 1 1 Queuine tRNA-ribosyltransferase TPR_1 PF00515.28 EKX73407.1 - 6.1e-58 190.4 41.5 6e-08 32.2 0.1 9.6 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_2 PF07719.17 EKX73407.1 - 7.9e-48 156.8 34.6 1.7e-05 24.6 0.0 9.5 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_11 PF13414.6 EKX73407.1 - 5.6e-33 112.4 27.6 2.7e-07 30.2 0.8 9.5 6 2 3 9 9 9 7 TPR repeat TPR_8 PF13181.6 EKX73407.1 - 1.4e-31 106.0 33.9 9.1e-05 22.4 0.1 9.7 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_19 PF14559.6 EKX73407.1 - 8.1e-23 80.7 21.7 1.2e-06 28.9 0.3 7.2 6 1 1 7 7 7 6 Tetratricopeptide repeat STI1 PF17830.1 EKX73407.1 - 3.9e-20 71.5 5.7 1e-16 60.6 1.2 3.3 3 0 0 3 3 2 2 STI1 domain TPR_12 PF13424.6 EKX73407.1 - 9.3e-20 70.7 20.2 7.9e-05 22.9 0.2 8.2 6 3 2 8 8 7 6 Tetratricopeptide repeat TPR_17 PF13431.6 EKX73407.1 - 2.1e-19 68.4 21.5 0.0044 17.3 0.2 8.5 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 EKX73407.1 - 3e-17 61.8 7.2 1.2 10.2 0.0 9.3 7 2 3 10 10 9 4 Tetratricopeptide repeat TPR_16 PF13432.6 EKX73407.1 - 9.7e-16 58.2 12.9 0.0005 20.7 0.4 6.6 6 1 1 7 7 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 EKX73407.1 - 9.4e-14 50.4 18.4 0.014 15.4 0.4 9.0 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_9 PF13371.6 EKX73407.1 - 1.1e-13 51.1 0.3 0.075 13.2 0.0 6.4 3 2 4 7 7 7 4 Tetratricopeptide repeat TPR_10 PF13374.6 EKX73407.1 - 3.1e-08 33.2 14.6 3.7 7.6 0.1 7.7 9 0 0 9 9 7 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EKX73407.1 - 1.5e-06 28.4 20.9 8.2e-05 22.8 4.6 5.3 4 2 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF3856 PF12968.7 EKX73407.1 - 1.9e-05 24.8 8.2 0.57 10.2 0.9 4.6 4 3 0 4 4 3 2 Domain of Unknown Function (DUF3856) TPR_20 PF14561.6 EKX73407.1 - 4e-05 23.9 9.2 0.5 10.7 0.0 5.6 4 1 2 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 EKX73407.1 - 6.8e-05 23.2 27.7 2.6 8.9 0.7 8.8 8 1 1 9 9 8 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EKX73407.1 - 0.00024 21.1 20.2 7 6.8 0.0 8.2 8 0 0 8 8 8 0 Fis1 C-terminal tetratricopeptide repeat Coatomer_E PF04733.14 EKX73407.1 - 0.00045 19.7 11.2 0.049 13.0 0.6 4.5 3 1 1 5 5 5 2 Coatomer epsilon subunit TPR_3 PF07720.12 EKX73407.1 - 0.0037 17.2 13.1 0.013 15.5 0.8 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 EKX73407.1 - 0.024 13.9 10.5 0.48 9.6 0.2 4.8 3 2 1 4 4 4 0 Tetratricopeptide repeat Flavodoxin_3 PF12641.7 EKX73407.1 - 0.057 13.1 0.8 0.38 10.4 0.1 2.5 2 0 0 2 2 2 0 Flavodoxin domain Virulence_fact PF13769.6 EKX73407.1 - 0.071 13.3 1.0 0.29 11.4 0.1 2.5 2 0 0 2 2 1 0 Virulence factor SNN_linker PF09050.10 EKX73407.1 - 0.16 11.7 0.8 0.38 10.6 0.8 1.6 1 0 0 1 1 1 0 Stannin unstructured linker BTAD PF03704.17 EKX73407.1 - 0.36 11.3 7.5 38 4.7 0.0 5.1 4 3 2 6 6 6 0 Bacterial transcriptional activator domain MIT PF04212.18 EKX73407.1 - 0.37 10.9 27.5 6.9 6.8 0.3 7.3 6 1 0 6 6 6 0 MIT (microtubule interacting and transport) domain Alkyl_sulf_dimr PF14863.6 EKX73407.1 - 0.39 11.2 4.6 1.7 9.1 0.4 3.2 3 0 0 3 3 3 0 Alkyl sulfatase dimerisation PPR PF01535.20 EKX73407.1 - 1 9.7 14.4 11 6.5 0.1 6.1 6 0 0 6 6 5 0 PPR repeat SHNi-TPR PF10516.9 EKX73407.1 - 1.1 8.8 9.6 19 4.8 0.0 5.8 7 0 0 7 7 6 0 SHNi-TPR SPO22 PF08631.10 EKX73407.1 - 1.6 8.2 8.1 2.3 7.6 0.6 3.6 4 0 0 4 4 4 0 Meiosis protein SPO22/ZIP4 like Clathrin PF00637.20 EKX73407.1 - 9.8 6.0 19.2 0.41 10.5 5.3 3.1 4 0 0 4 4 4 0 Region in Clathrin and VPS AAA_5 PF07728.14 EKX73409.1 - 2.1e-88 293.4 0.0 4.2e-20 72.2 0.0 8.8 8 0 0 8 8 8 7 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EKX73409.1 - 1.7e-28 99.1 0.0 7.1e-10 38.9 0.0 6.3 7 0 0 7 7 6 3 ATPase family associated with various cellular activities (AAA) AAA_lid_7 PF17867.1 EKX73409.1 - 5.8e-24 84.3 2.8 3.7e-10 39.9 0.2 6.1 5 0 0 5 5 5 3 Midasin AAA lid domain AAA_7 PF12775.7 EKX73409.1 - 2.4e-19 69.6 0.5 7.2e-06 25.6 0.1 5.6 5 0 0 5 5 5 4 P-loop containing dynein motor region AAA PF00004.29 EKX73409.1 - 2.7e-19 69.9 0.0 9.1e-05 22.9 0.0 5.8 5 0 0 5 5 5 4 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EKX73409.1 - 4.2e-19 69.6 0.0 0.013 15.9 0.0 5.8 5 0 0 5 5 5 4 AAA ATPase domain AAA_6 PF12774.7 EKX73409.1 - 1.7e-15 56.9 0.3 0.08 11.9 0.0 7.4 6 2 1 7 7 6 5 Hydrolytic ATP binding site of dynein motor region Dynein_heavy PF03028.15 EKX73409.1 - 5e-15 55.6 0.1 0.069 13.2 0.0 6.0 7 0 0 7 7 4 4 Dynein heavy chain region D6 P-loop domain AAA_lid_5 PF17865.1 EKX73409.1 - 6.8e-15 55.1 0.4 5.5e-13 48.9 0.0 3.4 3 0 0 3 3 2 1 Midasin AAA lid domain TsaE PF02367.17 EKX73409.1 - 2.1e-13 50.4 1.3 0.054 13.5 0.0 4.8 4 0 0 4 4 4 4 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 EKX73409.1 - 5e-11 43.0 0.0 0.27 11.5 0.0 5.9 5 0 0 5 5 5 2 AAA domain Sigma54_activat PF00158.26 EKX73409.1 - 1.5e-10 41.0 0.0 0.02 14.6 0.0 5.1 5 1 0 5 5 4 2 Sigma-54 interaction domain AAA_18 PF13238.6 EKX73409.1 - 2.9e-09 37.5 0.0 5 7.7 0.0 6.4 5 0 0 5 5 5 0 AAA domain Sigma54_activ_2 PF14532.6 EKX73409.1 - 9.8e-09 35.5 0.0 0.012 15.7 0.0 4.6 4 0 0 4 4 4 2 Sigma-54 interaction domain TniB PF05621.11 EKX73409.1 - 1.4e-07 31.1 0.0 0.097 12.1 0.0 4.8 4 0 0 4 4 4 1 Bacterial TniB protein T2SSE PF00437.20 EKX73409.1 - 1.9e-07 30.4 2.2 5.6 5.9 0.0 5.3 5 0 0 5 5 5 0 Type II/IV secretion system protein AAA_8 PF12780.7 EKX73409.1 - 5e-07 29.3 0.3 0.015 14.6 0.0 4.1 4 0 0 4 4 3 1 P-loop containing dynein motor region D4 NACHT PF05729.12 EKX73409.1 - 1e-06 28.8 0.5 2.2 8.2 0.0 4.6 4 0 0 4 4 4 2 NACHT domain Mg_chelatase PF01078.21 EKX73409.1 - 1.5e-06 27.8 1.0 0.2 11.0 0.1 6.2 6 1 0 6 6 6 1 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 EKX73409.1 - 1.6e-06 28.6 0.4 0.1 13.1 0.0 4.9 4 0 0 4 4 4 1 ABC transporter RNA_helicase PF00910.22 EKX73409.1 - 4e-06 27.2 0.9 11 6.5 0.0 6.0 6 0 0 6 6 4 0 RNA helicase AAA_29 PF13555.6 EKX73409.1 - 8.9e-06 25.4 0.3 14 5.6 0.0 5.4 5 0 0 5 5 5 0 P-loop containing region of AAA domain Rad17 PF03215.15 EKX73409.1 - 9.9e-06 25.6 6.0 12 5.7 0.0 6.8 7 0 0 7 7 7 0 Rad17 P-loop domain RuvB_N PF05496.12 EKX73409.1 - 1.3e-05 25.0 0.4 0.84 9.4 0.0 4.4 5 0 0 5 5 4 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EKX73409.1 - 1.6e-05 25.1 0.0 12 6.1 0.0 5.1 5 0 0 5 5 5 0 AAA domain MCM PF00493.23 EKX73409.1 - 2.8e-05 23.3 0.0 0.62 9.1 0.0 4.3 5 0 0 5 5 5 1 MCM P-loop domain DUF815 PF05673.13 EKX73409.1 - 7.6e-05 22.0 0.7 0.94 8.6 0.0 4.4 4 0 0 4 4 4 1 Protein of unknown function (DUF815) PduV-EutP PF10662.9 EKX73409.1 - 0.00018 21.3 0.1 1.2 8.8 0.0 3.8 3 0 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation Zeta_toxin PF06414.12 EKX73409.1 - 0.0003 20.1 0.0 31 3.8 0.0 4.7 4 0 0 4 4 4 0 Zeta toxin TIP49 PF06068.13 EKX73409.1 - 0.00044 19.6 2.1 0.49 9.5 0.1 3.5 4 0 0 4 4 3 2 TIP49 P-loop domain IstB_IS21 PF01695.17 EKX73409.1 - 0.00048 19.9 0.0 4.6 6.9 0.0 4.0 4 0 0 4 4 4 0 IstB-like ATP binding protein Roc PF08477.13 EKX73409.1 - 0.00062 20.0 3.7 0.82 9.9 0.1 4.3 5 0 0 5 5 3 1 Ras of Complex, Roc, domain of DAPkinase AAA_25 PF13481.6 EKX73409.1 - 0.00063 19.4 0.3 1.5 8.3 0.0 3.8 4 0 0 4 4 4 1 AAA domain RsgA_GTPase PF03193.16 EKX73409.1 - 0.0012 18.8 4.7 2.8 7.8 0.0 4.8 5 0 0 5 5 4 1 RsgA GTPase AAA_24 PF13479.6 EKX73409.1 - 0.0012 18.6 0.1 3.6 7.3 0.0 4.6 5 0 0 5 5 4 1 AAA domain AAA_30 PF13604.6 EKX73409.1 - 0.0015 18.3 0.0 6.2 6.5 0.0 4.3 4 0 0 4 4 4 0 AAA domain AAA_19 PF13245.6 EKX73409.1 - 0.0021 18.4 4.9 4.8 7.5 0.0 4.7 5 0 0 5 5 3 0 AAA domain PsaF PF17550.2 EKX73409.1 - 0.0087 15.6 0.0 0.026 14.1 0.0 1.8 1 0 0 1 1 1 1 Family of unknown function ATP-synt_ab PF00006.25 EKX73409.1 - 0.011 15.4 0.0 1.9 8.1 0.0 3.1 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain VWA PF00092.28 EKX73409.1 - 0.016 15.4 0.3 0.073 13.3 0.1 2.3 2 0 0 2 2 1 0 von Willebrand factor type A domain ResIII PF04851.15 EKX73409.1 - 0.018 15.0 0.0 13 5.8 0.0 3.0 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DEAD PF00270.29 EKX73409.1 - 0.019 14.7 0.0 8.3 6.1 0.0 3.8 4 0 0 4 4 3 0 DEAD/DEAH box helicase VWA_2 PF13519.6 EKX73409.1 - 0.037 14.7 0.0 0.31 11.7 0.0 2.8 1 0 0 1 1 1 0 von Willebrand factor type A domain SRP54 PF00448.22 EKX73409.1 - 0.048 13.3 1.4 6.7 6.3 0.0 3.7 4 0 0 4 4 3 0 SRP54-type protein, GTPase domain AAA_28 PF13521.6 EKX73409.1 - 0.08 13.2 1.9 53 4.0 0.0 5.1 5 0 0 5 5 5 0 AAA domain dNK PF01712.19 EKX73409.1 - 0.12 12.2 2.0 1.7 8.5 0.0 3.6 4 0 0 4 4 3 0 Deoxynucleoside kinase ATPase PF06745.13 EKX73409.1 - 1.4 8.2 9.9 0.9 8.8 0.0 4.5 5 0 0 5 5 4 0 KaiC cobW PF02492.19 EKX73409.1 - 2.5 7.7 4.5 33 4.0 0.1 3.9 4 0 0 4 4 4 0 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.15 EKX73409.1 - 2.9 7.8 8.6 11 5.9 0.1 4.4 5 0 0 5 5 4 0 NTPase MAM33 PF02330.16 EKX73410.1 - 4.7e-33 114.9 1.0 1.9e-32 112.9 1.0 1.7 1 1 0 1 1 1 1 Mitochondrial glycoprotein DUF2095 PF09868.9 EKX73410.1 - 0.054 13.5 0.2 11 6.0 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2095) Peptidase_M24 PF00557.24 EKX73412.1 - 7.1e-44 150.0 0.0 8.9e-44 149.7 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Tweety PF04906.13 EKX73412.1 - 0.15 10.7 0.0 0.26 9.9 0.0 1.3 1 0 0 1 1 1 0 Tweety COX15-CtaA PF02628.15 EKX73413.1 - 6.2e-87 291.7 5.8 7.2e-87 291.5 5.8 1.0 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein RNase_H2-Ydr279 PF09468.10 EKX73414.1 - 5.7e-09 36.3 0.1 1.4e-08 35.1 0.1 1.7 1 1 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain DUF1077 PF06417.12 EKX73415.1 - 1.4e-14 54.1 1.2 1.7e-14 53.8 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) DUF3985 PF13153.6 EKX73415.1 - 0.016 15.2 2.0 0.042 13.9 2.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3985) Clathrin_lg_ch PF01086.17 EKX73416.1 - 0.00042 20.4 13.9 0.00053 20.1 13.9 1.1 1 0 0 1 1 1 1 Clathrin light chain DUF737 PF05300.11 EKX73416.1 - 0.019 15.3 10.9 0.024 15.0 10.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF737) AP3B1_C PF14796.6 EKX73416.1 - 0.071 13.4 0.1 0.11 12.8 0.1 1.3 1 0 0 1 1 1 0 Clathrin-adaptor complex-3 beta-1 subunit C-terminal Endonuc_Holl PF10107.9 EKX73416.1 - 0.5 10.2 7.1 0.82 9.5 7.1 1.3 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase CRPV_capsid PF08762.10 EKX73418.1 - 0.012 15.3 1.3 0.072 12.7 0.2 2.6 2 0 0 2 2 2 0 CRPV capsid protein like FAINT PF04385.15 EKX73419.1 - 1.2e-16 60.5 9.1 3.7e-06 26.9 0.4 4.6 4 0 0 4 4 4 4 Domain of unknown function, DUF529 SHOCT PF09851.9 EKX73419.1 - 7.7 6.4 7.6 0.45 10.3 0.7 2.2 2 0 0 2 2 2 0 Short C-terminal domain Pterin_4a PF01329.19 EKX73420.1 - 0.17 12.1 0.0 0.4 10.9 0.0 1.6 1 0 0 1 1 1 0 Pterin 4 alpha carbinolamine dehydratase Spc7 PF08317.11 EKX73421.1 - 0.0017 17.3 33.8 0.0032 16.4 13.2 7.4 2 1 7 9 9 9 2 Spc7 kinetochore protein DUF1664 PF07889.12 EKX73421.1 - 0.0034 17.4 1.7 0.0034 17.4 1.7 8.9 4 3 6 10 10 10 4 Protein of unknown function (DUF1664) TMCO5 PF14992.6 EKX73421.1 - 0.0043 16.7 25.1 0.0043 16.7 25.1 6.9 3 1 3 6 6 6 2 TMCO5 family GAS PF13851.6 EKX73421.1 - 0.095 12.0 149.6 0.013 14.8 24.3 8.1 2 1 5 9 9 9 0 Growth-arrest specific micro-tubule binding DUF4041 PF13250.6 EKX73421.1 - 4.2 7.3 18.5 0.28 11.1 0.4 5.7 6 0 0 6 6 6 0 Domain of unknown function (DUF4041) BOP1NT PF08145.12 EKX73422.1 - 5.5e-94 314.9 8.8 8e-94 314.4 8.8 1.2 1 0 0 1 1 1 1 BOP1NT (NUC169) domain DNA_pol_phi PF04931.13 EKX73423.1 - 0.4 8.7 7.1 0.59 8.2 7.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi cobW PF02492.19 EKX73425.1 - 6.2e-36 123.6 0.2 1.3e-35 122.6 0.2 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EKX73425.1 - 1.1e-06 28.5 0.0 2.6e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain NRBF2 PF08961.10 EKX73425.1 - 0.00042 20.0 1.3 0.00073 19.2 1.3 1.3 1 0 0 1 1 1 1 Nuclear receptor-binding factor 2, autophagy regulator AAA_33 PF13671.6 EKX73425.1 - 0.0043 17.2 0.2 0.28 11.3 0.0 2.7 3 0 0 3 3 3 1 AAA domain MeaB PF03308.16 EKX73425.1 - 0.011 14.7 0.3 2 7.3 0.0 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_7 PF12775.7 EKX73425.1 - 0.02 14.4 1.5 0.15 11.5 0.1 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_16 PF13191.6 EKX73425.1 - 0.022 15.1 0.0 0.055 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain DUF2205 PF10224.9 EKX73425.1 - 0.035 14.1 1.6 0.11 12.5 1.6 1.9 1 0 0 1 1 1 0 Short coiled-coil protein TsaE PF02367.17 EKX73425.1 - 0.04 13.9 0.6 0.081 12.9 0.1 1.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 EKX73425.1 - 0.053 13.2 0.1 0.2 11.3 0.1 1.9 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EKX73425.1 - 0.073 13.5 0.8 6.3 7.2 0.1 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EKX73425.1 - 0.075 13.6 0.8 0.5 10.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain Rox3 PF08633.10 EKX73425.1 - 0.097 12.9 0.5 0.17 12.2 0.5 1.3 1 0 0 1 1 1 0 Rox3 mediator complex subunit AAA_22 PF13401.6 EKX73425.1 - 0.16 12.2 0.6 0.55 10.5 0.1 2.1 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EKX73425.1 - 0.22 11.4 3.6 1.3 8.9 0.4 2.6 2 1 0 2 2 2 0 RsgA GTPase AAA_19 PF13245.6 EKX73425.1 - 0.56 10.5 3.1 2.2 8.6 0.2 2.8 3 0 0 3 3 3 0 AAA domain CbiA PF01656.23 EKX73425.1 - 8.2 6.5 5.7 85 3.2 5.7 2.9 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Porin_3 PF01459.22 EKX73426.1 - 4.5e-07 29.6 0.5 1.6e-06 27.8 0.5 1.8 1 1 0 1 1 1 1 Eukaryotic porin Ribosomal_L35Ae PF01247.18 EKX73427.1 - 2.3e-41 139.9 0.6 2.6e-41 139.7 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 EKX73427.1 - 0.0016 18.6 0.0 0.96 9.7 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain Cyclin_N PF00134.23 EKX73428.1 - 5.5e-05 22.9 0.7 0.00013 21.7 0.7 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain FAINT PF04385.15 EKX73429.1 - 3.3e-05 23.9 0.0 7.2e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function, DUF529 BpuJI_N PF11564.8 EKX73429.1 - 0.031 13.5 0.1 0.054 12.7 0.1 1.3 1 0 0 1 1 1 0 Restriction endonuclease BpuJI - N terminal RVT_1 PF00078.27 EKX73430.1 - 3.7e-16 59.3 0.0 6.9e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PKD PF00801.20 EKX73431.1 - 0.11 12.4 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 PKD domain FAINT PF04385.15 EKX73432.1 - 1.4e-16 60.3 1.8 3e-08 33.6 0.3 2.2 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Pollen_allerg_1 PF01357.21 EKX73432.1 - 0.033 14.2 0.1 0.12 12.4 0.1 2.0 2 0 0 2 2 2 0 Pollen allergen RVT_1 PF00078.27 EKX73433.1 - 4.3e-35 121.2 0.1 7.5e-35 120.5 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SOCS_box PF07525.16 EKX73433.1 - 0.089 13.2 0.4 9.5 6.7 0.0 3.3 3 0 0 3 3 3 0 SOCS box FAINT PF04385.15 EKX73435.1 - 4.7e-08 33.0 0.2 1.2e-05 25.2 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 RHH_7 PF16777.5 EKX73435.1 - 0.5 10.8 2.0 1.2 9.6 0.1 2.3 2 0 0 2 2 2 0 Transcriptional regulator, RHH-like, CopG FAINT PF04385.15 EKX73436.1 - 7.9e-12 45.1 5.5 8.9e-06 25.7 1.7 2.8 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Tektin PF03148.14 EKX73436.1 - 0.0016 17.3 0.3 0.0039 16.0 0.3 1.6 1 0 0 1 1 1 1 Tektin family TMP_2 PF06791.13 EKX73436.1 - 0.043 13.5 1.3 0.091 12.4 1.3 1.5 1 0 0 1 1 1 0 Prophage tail length tape measure protein SesA PF17107.5 EKX73436.1 - 0.093 12.9 3.3 3.1 8.0 4.0 2.6 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases ATP-synt_DE PF00401.20 EKX73436.1 - 0.67 10.3 2.1 1.7 9.0 0.3 2.3 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain DUF4175 PF13779.6 EKX73436.1 - 1.1 7.1 8.2 0.18 9.6 4.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4175) Tfb5 PF06331.12 EKX73437.1 - 5.6e-10 39.1 0.1 7.1e-10 38.7 0.1 1.1 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 DHHC PF01529.20 EKX73440.1 - 1.7e-28 99.4 15.3 1.7e-28 99.4 15.3 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase PocR PF10114.9 EKX73440.1 - 0.076 12.8 3.6 0.12 12.1 3.6 1.3 1 0 0 1 1 1 0 Sensory domain found in PocR DUF2207 PF09972.9 EKX73440.1 - 0.64 8.7 7.5 0.76 8.5 0.1 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF4131 PF13567.6 EKX73440.1 - 0.69 9.5 0.0 0.69 9.5 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) Pkinase PF00069.25 EKX73441.1 - 1.8e-62 211.1 0.0 8.2e-62 208.9 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain cNMP_binding PF00027.29 EKX73441.1 - 3.8e-58 193.5 0.5 2.2e-17 62.9 0.0 4.4 4 0 0 4 4 4 4 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 EKX73441.1 - 8.9e-33 113.7 0.0 3.2e-32 111.8 0.0 1.9 3 0 0 3 3 3 1 Protein tyrosine kinase Kinase-like PF14531.6 EKX73441.1 - 3.5e-05 23.3 0.0 5.7e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Cupin_2 PF07883.11 EKX73441.1 - 8.6e-05 22.2 5.1 0.48 10.2 0.1 4.3 4 0 0 4 4 4 1 Cupin domain Pkinase_fungal PF17667.1 EKX73441.1 - 0.00064 18.6 0.0 0.002 17.0 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EKX73441.1 - 0.012 15.5 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EKX73441.1 - 0.027 13.8 0.0 0.051 12.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EKX73441.1 - 0.043 12.8 0.1 0.086 11.8 0.1 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Metallophos PF00149.28 EKX73442.1 - 2.8e-08 34.5 0.6 4.4e-08 33.9 0.6 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase HIT PF01230.23 EKX73443.1 - 1.1e-25 90.2 0.5 3.2e-25 88.7 0.2 1.8 1 1 1 2 2 2 1 HIT domain DcpS_C PF11969.8 EKX73443.1 - 4.1e-20 72.4 0.4 6.5e-20 71.7 0.4 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Peptidase_M48_N PF16491.5 EKX73445.1 - 2.8e-52 177.3 7.5 2.8e-52 177.3 7.5 1.9 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 EKX73445.1 - 7.1e-35 120.6 0.1 1.1e-34 119.9 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M48 Cation_ATPase_C PF00689.21 EKX73445.1 - 0.066 12.9 10.8 0.056 13.2 1.9 2.5 2 1 0 2 2 2 0 Cation transporting ATPase, C-terminus Peptidase_U4 PF03419.13 EKX73445.1 - 2.9 7.1 12.1 0.13 11.5 2.4 2.2 2 0 0 2 2 2 0 Sporulation factor SpoIIGA Proteasome PF00227.26 EKX73446.1 - 1.5e-42 145.2 0.2 1.8e-42 145.0 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EKX73446.1 - 1.5e-13 50.1 0.0 2.8e-13 49.3 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature PGM_PMM_I PF02878.16 EKX73447.1 - 2.4e-11 43.5 0.0 3.1e-07 30.2 0.0 2.5 1 1 1 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 EKX73447.1 - 2.6e-08 33.9 0.0 5.2e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain DmpG_comm PF07836.11 EKX73447.1 - 0.11 12.0 0.3 15 5.2 0.1 3.1 3 0 0 3 3 3 0 DmpG-like communication domain Longin PF13774.6 EKX73449.1 - 1.6e-09 37.7 0.0 2.9e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 EKX73449.1 - 3.4e-08 33.2 0.8 6.3e-08 32.3 0.8 1.5 1 0 0 1 1 1 1 Synaptobrevin Imm42 PF15593.6 EKX73449.1 - 0.021 15.3 0.8 0.031 14.8 0.8 1.4 1 0 0 1 1 1 0 Immunity protein 42 Seryl_tRNA_N PF02403.22 EKX73449.1 - 0.057 13.7 0.5 0.089 13.0 0.5 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Syntaxin_2 PF14523.6 EKX73449.1 - 1.2 9.5 4.8 2.5 8.5 4.8 1.5 1 0 0 1 1 1 0 Syntaxin-like protein TruD PF01142.18 EKX73450.1 - 6.7e-61 206.3 0.0 3.2e-31 108.6 0.0 3.9 4 0 0 4 4 4 3 tRNA pseudouridine synthase D (TruD) DUF3337 PF11816.8 EKX73450.1 - 0.052 13.4 0.1 0.28 11.0 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3337) MRP-L28 PF09812.9 EKX73451.1 - 0.00034 20.8 1.0 0.00034 20.8 1.0 1.7 2 0 0 2 2 2 1 Mitochondrial ribosomal protein L28 ARL2_Bind_BART PF11527.8 EKX73451.1 - 0.038 14.1 0.6 0.057 13.5 0.6 1.4 1 0 0 1 1 1 0 The ARF-like 2 binding protein BART YjeF_N PF03853.15 EKX73452.1 - 1.8e-30 106.1 0.0 2.2e-30 105.8 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus Bax1-I PF01027.20 EKX73453.1 - 3.1e-25 89.2 18.3 3.6e-25 89.0 18.3 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF3043 PF11241.8 EKX73453.1 - 1.1 9.3 5.2 2.1 8.3 4.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3043) zf-RING_2 PF13639.6 EKX73454.1 - 1.9e-06 28.1 9.5 1.9e-06 28.1 9.5 3.1 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 EKX73454.1 - 1.4e-05 25.3 6.5 7.7e-05 22.9 6.5 2.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain FANCL_C PF11793.8 EKX73454.1 - 0.00015 21.8 7.1 0.00015 21.8 7.1 3.4 3 0 0 3 3 3 1 FANCL C-terminal domain zf-ANAPC11 PF12861.7 EKX73454.1 - 0.00085 19.3 6.1 0.0016 18.4 4.4 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 EKX73454.1 - 0.012 15.5 9.4 0.066 13.1 9.4 2.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EKX73454.1 - 0.019 14.6 6.3 0.081 12.6 6.3 2.1 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 EKX73454.1 - 0.24 11.4 7.4 0.91 9.6 7.4 2.1 1 0 0 1 1 1 0 RING-type zinc-finger RTP1_C1 PF10363.9 EKX73454.1 - 0.4 10.9 6.1 0.93 9.7 0.0 3.7 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 zf-RING-like PF08746.11 EKX73454.1 - 0.79 10.1 13.4 0.51 10.7 8.6 3.2 2 0 0 2 2 2 0 RING-like domain AF0941-like PF14591.6 EKX73454.1 - 1 9.9 5.6 2.9 8.5 0.1 4.0 3 0 0 3 3 3 0 AF0941-like Form_Nir_trans PF01226.17 EKX73455.1 - 2.7e-55 187.3 15.9 3e-55 187.1 15.9 1.0 1 0 0 1 1 1 1 Formate/nitrite transporter AAA PF00004.29 EKX73456.1 - 3.2e-36 124.6 0.1 5.8e-36 123.8 0.1 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EKX73456.1 - 9.3e-06 25.4 0.0 2.6e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EKX73456.1 - 5.5e-05 23.2 0.0 0.00022 21.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EKX73456.1 - 9.1e-05 22.6 0.0 0.00019 21.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EKX73456.1 - 0.00015 21.6 0.0 0.00031 20.5 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 EKX73456.1 - 0.00044 19.9 0.6 0.15 11.6 0.1 2.3 1 1 1 2 2 2 2 AAA domain AAA_14 PF13173.6 EKX73456.1 - 0.0011 19.0 0.0 0.0041 17.1 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EKX73456.1 - 0.0011 19.2 0.0 0.0064 16.8 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EKX73456.1 - 0.0036 17.7 0.0 0.0078 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.13 EKX73456.1 - 0.0045 16.2 0.0 0.011 15.0 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_18 PF13238.6 EKX73456.1 - 0.005 17.4 0.1 0.026 15.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EKX73456.1 - 0.0054 16.8 0.0 0.0054 16.8 0.0 2.7 3 1 0 3 3 3 1 50S ribosome-binding GTPase AAA_24 PF13479.6 EKX73456.1 - 0.0061 16.3 0.9 0.07 12.9 0.9 2.5 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EKX73456.1 - 0.031 14.8 0.1 0.18 12.3 0.0 2.3 2 0 0 2 2 2 0 ABC transporter Mg_chelatase PF01078.21 EKX73456.1 - 0.036 13.4 0.0 0.082 12.3 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI MCM PF00493.23 EKX73456.1 - 0.062 12.4 0.0 0.14 11.3 0.0 1.5 1 0 0 1 1 1 0 MCM P-loop domain AAA_19 PF13245.6 EKX73456.1 - 0.063 13.6 0.3 0.23 11.8 0.1 1.9 2 1 0 2 2 1 0 AAA domain Vps4_C PF09336.10 EKX73456.1 - 0.094 12.7 0.0 0.36 10.9 0.0 2.1 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain IstB_IS21 PF01695.17 EKX73456.1 - 0.12 12.2 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.6 EKX73456.1 - 0.12 12.6 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain Torsin PF06309.11 EKX73456.1 - 0.15 12.2 0.3 2 8.5 0.0 2.7 3 0 0 3 3 3 0 Torsin AAA_30 PF13604.6 EKX73456.1 - 0.22 11.2 0.0 0.43 10.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain GBP PF02263.19 EKX73457.1 - 4e-05 23.0 0.1 9.9e-05 21.7 0.1 1.6 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain zf-RanBP PF00641.18 EKX73458.1 - 1.9e-12 46.3 16.2 1.9e-06 27.0 2.1 2.1 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others zf-UBR PF02207.20 EKX73458.1 - 0.0018 18.4 5.5 0.0025 17.9 5.5 1.2 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) DZR PF12773.7 EKX73458.1 - 0.0019 18.2 8.4 0.0031 17.5 8.4 1.3 1 0 0 1 1 1 1 Double zinc ribbon zf-P11 PF03854.14 EKX73458.1 - 0.012 15.3 1.5 2.5 7.8 0.3 2.2 2 0 0 2 2 2 0 P-11 zinc finger RecR PF02132.15 EKX73458.1 - 0.029 13.9 8.6 0.11 12.0 1.6 2.4 2 0 0 2 2 2 0 RecR protein zf-ribbon_3 PF13248.6 EKX73458.1 - 0.043 13.2 12.4 0.91 9.0 0.2 2.9 3 0 0 3 3 3 0 zinc-ribbon domain C1_2 PF03107.16 EKX73458.1 - 2.7 8.4 11.0 32 5.0 0.2 3.2 1 1 1 2 2 2 0 C1 domain HypA PF01155.19 EKX73458.1 - 4.9 7.2 6.6 8.7 6.4 5.2 1.9 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-HIT PF04438.16 EKX73458.1 - 6.5 6.7 8.6 23 4.9 1.2 3.1 3 0 0 3 3 3 0 HIT zinc finger XPG_I PF00867.18 EKX73459.1 - 3.1e-27 94.7 0.1 8.4e-27 93.4 0.1 1.8 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 EKX73459.1 - 6e-27 94.1 0.0 1.6e-26 92.7 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 EKX73459.1 - 4.3e-05 24.0 0.1 0.0002 21.9 0.0 2.2 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold 5_3_exonuc_N PF02739.16 EKX73459.1 - 5.9e-05 23.0 0.0 0.00015 21.7 0.0 1.7 1 1 0 1 1 1 1 5'-3' exonuclease, N-terminal resolvase-like domain HHH_2 PF12826.7 EKX73459.1 - 0.0045 17.1 0.0 0.023 14.8 0.0 2.2 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 EKX73459.1 - 0.06 14.0 0.1 0.36 11.5 0.0 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix domain SRP54_N PF02881.19 EKX73459.1 - 0.068 13.4 0.1 0.068 13.4 0.1 2.5 3 0 0 3 3 3 0 SRP54-type protein, helical bundle domain DUF1233 PF06806.12 EKX73460.1 - 0.0083 15.7 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 Putative excisionase (DUF1233) Nipped-B_C PF12830.7 EKX73461.1 - 0.025 14.5 0.1 0.05 13.5 0.1 1.5 1 0 0 1 1 1 0 Sister chromatid cohesion C-terminus Pkinase PF00069.25 EKX73462.1 - 5e-46 157.2 0.1 7e-46 156.7 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKX73462.1 - 1.2e-22 80.5 0.1 1.8e-22 79.9 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKX73462.1 - 4.3e-08 32.8 0.0 6.3e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EKX73462.1 - 1.6e-05 23.9 0.0 3.2e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Choline_kinase PF01633.20 EKX73462.1 - 0.00054 19.6 0.1 0.0015 18.2 0.1 1.7 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EKX73462.1 - 0.0057 16.6 0.0 0.0087 16.0 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EKX73462.1 - 0.022 14.1 0.4 0.07 12.5 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family RNase_P_p30 PF01876.16 EKX73463.1 - 1.3e-15 57.4 0.0 7.8e-15 54.9 0.0 2.1 1 1 0 1 1 1 1 RNase P subunit p30 s48_45 PF07422.13 EKX73465.1 - 0.013 16.1 5.8 0.034 14.7 0.1 3.5 4 0 0 4 4 4 0 Sexual stage antigen s48/45 domain OFCC1 PF15680.5 EKX73465.1 - 0.17 12.5 0.0 6.6 7.4 0.0 2.4 2 0 0 2 2 2 0 Orofacial cleft 1 candidate gene 1 protein FAD_binding_3 PF01494.19 EKX73466.1 - 4.5e-49 167.6 0.0 3.5e-31 108.7 0.0 2.7 3 0 0 3 3 3 2 FAD binding domain NHR2 PF08788.11 EKX73466.1 - 0.16 11.8 0.6 1.5 8.7 0.0 2.6 3 0 0 3 3 3 0 NHR2 domain like MAGP PF05507.11 EKX73467.1 - 0.097 13.1 0.1 0.25 11.7 0.1 1.7 1 0 0 1 1 1 0 Microfibril-associated glycoprotein (MAGP) Actin PF00022.19 EKX73468.1 - 1.6e-142 474.9 0.0 1.3e-141 471.9 0.0 1.9 1 1 0 1 1 1 1 Actin PIG-S PF10510.9 EKX73469.1 - 6.8e-14 51.6 0.5 2.7e-13 49.6 0.5 1.8 1 1 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein Mis12 PF05859.12 EKX73469.1 - 0.0083 16.2 0.4 6.1 6.9 0.1 2.5 2 0 0 2 2 2 2 Mis12 protein DUF1654 PF07867.11 EKX73469.1 - 0.0092 15.7 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1654) Pro_isomerase PF00160.21 EKX73470.1 - 2.9e-48 164.1 0.4 4.5e-48 163.5 0.4 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD FKBP_C PF00254.28 EKX73470.1 - 2.5e-32 111.0 0.0 5.8e-32 109.9 0.0 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.17 EKX73470.1 - 2.9e-07 30.1 2.5 0.011 15.8 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EKX73470.1 - 1.6e-05 24.9 0.1 2.7e-05 24.2 0.1 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 EKX73470.1 - 0.00058 19.6 8.8 0.017 14.9 0.1 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 EKX73470.1 - 0.00098 18.8 6.6 0.06 13.0 0.8 3.4 2 1 1 3 3 3 1 TPR repeat TPR_8 PF13181.6 EKX73470.1 - 0.0027 17.8 3.2 0.61 10.4 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EKX73470.1 - 0.017 15.2 0.8 0.27 11.4 0.1 2.4 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 EKX73470.1 - 0.043 14.0 3.6 0.053 13.8 2.1 2.0 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 EKX73470.1 - 0.08 13.8 0.3 0.88 10.6 0.3 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat MAM PF00629.23 EKX73471.1 - 0.058 13.3 0.5 0.083 12.8 0.5 1.3 1 0 0 1 1 1 0 MAM domain, meprin/A5/mu Importin_rep PF18773.1 EKX73471.1 - 0.87 9.3 3.2 1.5 8.6 3.2 1.4 1 0 0 1 1 1 0 Importin 13 repeat LXG PF04740.12 EKX73475.1 - 0.069 12.9 0.2 0.64 9.7 0.1 2.6 2 0 0 2 2 2 0 LXG domain of WXG superfamily AAA PF00004.29 EKX73477.1 - 7.4e-43 146.1 0.0 1.5e-42 145.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EKX73477.1 - 3.8e-14 52.2 0.1 7.7e-14 51.2 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EKX73477.1 - 4.7e-08 33.1 0.0 1.4e-07 31.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EKX73477.1 - 7.4e-07 29.4 0.0 1.4e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EKX73477.1 - 1.1e-06 29.2 2.4 1.3e-05 25.7 0.7 3.2 2 1 0 2 2 1 1 AAA ATPase domain Prot_ATP_ID_OB PF16450.5 EKX73477.1 - 3.5e-06 26.9 0.6 9.9e-06 25.4 0.6 1.8 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain RuvB_N PF05496.12 EKX73477.1 - 7.3e-05 22.6 0.0 0.00015 21.5 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EKX73477.1 - 0.00015 22.1 0.7 0.0097 16.2 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.6 EKX73477.1 - 0.0009 19.4 0.9 0.0029 17.8 0.0 2.2 2 1 0 2 2 2 1 AAA domain TIP49 PF06068.13 EKX73477.1 - 0.0013 18.1 0.0 0.0028 16.9 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 EKX73477.1 - 0.0032 17.2 0.0 0.0056 16.4 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 EKX73477.1 - 0.0043 17.6 0.0 0.013 16.0 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_3 PF07726.11 EKX73477.1 - 0.0044 16.9 0.0 0.015 15.1 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EKX73477.1 - 0.0078 16.5 0.1 0.023 14.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 EKX73477.1 - 0.008 15.5 0.2 0.031 13.6 0.0 2.0 3 0 0 3 3 3 1 KaiC Mg_chelatase PF01078.21 EKX73477.1 - 0.012 15.0 0.1 0.026 13.9 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EKX73477.1 - 0.017 15.5 0.0 0.037 14.4 0.0 1.6 1 0 0 1 1 1 0 RNA helicase TsaE PF02367.17 EKX73477.1 - 0.018 15.0 0.0 0.034 14.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EKX73477.1 - 0.021 14.4 0.0 0.038 13.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EKX73477.1 - 0.029 14.1 0.0 0.067 12.9 0.0 1.8 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EKX73477.1 - 0.032 14.0 0.0 0.11 12.2 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain Parvo_NS1 PF01057.17 EKX73477.1 - 0.043 12.9 0.0 0.077 12.1 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 PhoH PF02562.16 EKX73477.1 - 0.045 13.2 0.0 0.15 11.5 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein DUF2540 PF10802.8 EKX73477.1 - 0.053 13.6 0.1 2.2 8.4 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2540) DUF815 PF05673.13 EKX73477.1 - 0.056 12.6 0.0 0.092 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_25 PF13481.6 EKX73477.1 - 0.057 13.0 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EKX73477.1 - 0.071 12.9 0.1 0.27 11.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain DUF2072 PF09845.9 EKX73477.1 - 0.071 13.4 0.1 0.15 12.3 0.1 1.5 1 0 0 1 1 1 0 Zn-ribbon containing protein AAA_14 PF13173.6 EKX73477.1 - 0.076 13.1 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EKX73477.1 - 0.095 12.6 0.0 0.71 9.8 0.0 2.1 2 0 0 2 2 2 0 NACHT domain Zeta_toxin PF06414.12 EKX73477.1 - 0.11 11.8 0.0 0.23 10.7 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_17 PF13207.6 EKX73477.1 - 0.11 12.9 0.0 0.34 11.3 0.0 1.9 2 0 0 2 2 1 0 AAA domain ABC_tran PF00005.27 EKX73477.1 - 0.12 12.8 0.0 0.28 11.7 0.0 1.9 1 1 0 1 1 1 0 ABC transporter THUMP PF02926.17 EKX73478.1 - 1.7e-10 41.2 0.8 1.9e-09 37.7 0.8 2.1 1 1 0 1 1 1 1 THUMP domain FYDLN_acid PF09538.10 EKX73478.1 - 0.005 17.5 2.0 0.017 15.8 0.2 2.1 2 0 0 2 2 2 1 Protein of unknown function (FYDLN_acid) PP2C PF00481.21 EKX73479.1 - 1.4e-46 159.2 0.0 4.1e-46 157.7 0.0 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EKX73479.1 - 8.2e-05 22.3 0.0 0.0012 18.6 0.0 2.3 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EKX73479.1 - 0.0026 17.7 0.1 0.008 16.1 0.0 1.8 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) Tho2 PF11262.8 EKX73480.1 - 1.1e-68 231.7 0.4 1.1e-68 231.7 0.4 2.7 3 0 0 3 3 3 1 Transcription factor/nuclear export subunit protein 2 THOC2_N PF16134.5 EKX73480.1 - 3.8e-13 49.0 16.5 1.6e-07 30.4 0.1 3.5 3 1 0 3 3 3 2 THO complex subunit 2 N-terminus Thoc2 PF11732.8 EKX73480.1 - 2.1e-08 34.1 1.6 1.3e-07 31.5 0.3 2.9 3 0 0 3 3 3 1 Transcription- and export-related complex subunit FAINT PF04385.15 EKX73481.1 - 2.4e-05 24.3 0.8 0.04 14.0 0.0 3.1 2 2 1 4 4 4 2 Domain of unknown function, DUF529 Thr_dehydrat_C PF00585.18 EKX73481.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 C-terminal regulatory domain of Threonine dehydratase FAINT PF04385.15 EKX73482.1 - 1.5e-10 41.0 0.2 3.2e-05 23.9 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 CNDH2_M PF16869.5 EKX73484.1 - 0.043 14.5 2.5 0.076 13.7 2.5 1.5 1 0 0 1 1 1 0 PF16858 FAINT PF04385.15 EKX73485.1 - 1.2e-18 66.9 9.2 2.6e-06 27.4 0.1 4.6 4 0 0 4 4 4 4 Domain of unknown function, DUF529 GATA PF00320.27 EKX73485.1 - 0.023 14.3 2.2 0.03 13.9 0.3 2.1 2 0 0 2 2 2 0 GATA zinc finger WYL_2 PF10902.8 EKX73485.1 - 0.11 12.8 1.4 1.2 9.6 0.2 2.6 2 0 0 2 2 2 0 WYL_2, Sm-like SH3 beta-barrel fold Fcf2 PF08698.11 EKX73486.1 - 9.2e-13 48.4 0.0 2.3e-12 47.2 0.0 1.6 1 0 0 1 1 1 1 Fcf2 pre-rRNA processing Peptidase_C1 PF00112.23 EKX73487.1 - 4.3e-38 131.6 3.0 1.2e-37 130.1 3.0 1.8 1 0 0 1 1 1 1 Papain family cysteine protease CathepsinC_exc PF08773.11 EKX73487.1 - 7.7e-10 39.1 1.5 1.3e-07 31.9 1.5 3.5 1 1 0 1 1 1 1 Cathepsin C exclusion domain Peptidase_C1_2 PF03051.15 EKX73487.1 - 0.065 12.0 1.5 0.26 10.0 1.2 1.9 1 1 1 2 2 2 0 Peptidase C1-like family ABC_membrane PF00664.23 EKX73489.1 - 5e-35 121.5 13.7 7.7e-35 120.9 13.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EKX73489.1 - 1.8e-34 119.2 0.1 3.8e-34 118.1 0.1 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EKX73489.1 - 2.7e-07 30.3 1.8 1.1e-06 28.2 1.8 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EKX73489.1 - 0.00017 21.5 0.0 0.00051 20.0 0.0 1.8 1 0 0 1 1 1 1 RsgA GTPase AAA_21 PF13304.6 EKX73489.1 - 0.0011 18.8 2.3 0.57 9.9 2.3 2.4 1 1 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system ABC_ATPase PF09818.9 EKX73489.1 - 0.007 15.2 0.0 0.032 13.1 0.0 2.1 2 1 0 2 2 2 1 Predicted ATPase of the ABC class AAA_23 PF13476.6 EKX73489.1 - 0.036 14.6 1.1 0.08 13.4 0.5 1.8 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EKX73489.1 - 0.052 13.8 0.2 0.16 12.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EKX73489.1 - 0.055 13.2 0.0 0.21 11.4 0.0 2.0 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.6 EKX73489.1 - 0.085 12.9 0.2 1.4 8.9 0.0 2.9 3 1 0 3 3 3 0 AAA domain AAA_7 PF12775.7 EKX73489.1 - 0.086 12.4 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region ATP-synt_ab PF00006.25 EKX73489.1 - 0.14 11.8 0.0 0.35 10.5 0.0 1.7 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain NTPase_1 PF03266.15 EKX73489.1 - 0.15 11.9 0.1 9.7 6.1 0.0 2.5 2 0 0 2 2 2 0 NTPase FAINT PF04385.15 EKX73490.1 - 2.8e-10 40.1 0.5 0.00039 20.4 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Bud13 PF09736.9 EKX73491.1 - 0.0046 17.3 0.5 0.0092 16.4 0.5 1.5 1 0 0 1 1 1 1 Pre-mRNA-splicing factor of RES complex zf_CCCH_4 PF18345.1 EKX73492.1 - 5.5e-06 26.3 0.4 1.5e-05 24.9 0.4 1.8 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 EKX73492.1 - 6.6e-05 22.7 0.8 0.00022 21.1 0.2 2.2 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EKX73492.1 - 0.00053 20.6 0.0 0.00099 19.8 0.0 1.5 1 0 0 1 1 1 1 Torus domain zf-CCCH_4 PF18044.1 EKX73492.1 - 0.00071 19.3 0.5 0.0015 18.3 0.5 1.6 1 0 0 1 1 1 1 CCCH-type zinc finger FYVE PF01363.21 EKX73492.1 - 0.64 10.2 8.7 0.18 11.9 4.9 2.3 2 1 0 2 2 2 0 FYVE zinc finger EF-hand_6 PF13405.6 EKX73493.1 - 0.00099 18.9 3.1 0.093 12.7 0.1 3.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 EKX73493.1 - 0.0013 18.1 0.9 0.025 14.1 0.4 2.6 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 EKX73493.1 - 0.0054 16.6 0.9 0.021 14.7 0.3 2.3 2 1 0 2 2 2 1 EF-hand domain pair Bacillus_HBL PF05791.11 EKX73493.1 - 0.0085 15.9 1.4 0.015 15.2 1.4 1.4 1 0 0 1 1 1 1 Bacillus haemolytic enterotoxin (HBL) FTA4 PF13093.6 EKX73493.1 - 0.009 15.9 0.1 0.011 15.7 0.1 1.2 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DUF148 PF02520.17 EKX73493.1 - 0.01 15.9 1.6 0.11 12.7 1.6 2.3 1 1 0 1 1 1 0 Domain of unknown function DUF148 EF-hand_7 PF13499.6 EKX73493.1 - 0.019 15.4 3.5 0.054 14.0 1.9 2.6 2 1 0 2 2 2 0 EF-hand domain pair Spc7 PF08317.11 EKX73493.1 - 0.031 13.2 0.6 0.052 12.4 0.6 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.6 EKX73493.1 - 0.18 11.1 0.1 0.34 10.2 0.1 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) GrpE PF01025.19 EKX73493.1 - 0.26 10.9 3.1 0.39 10.4 1.0 2.1 2 0 0 2 2 2 0 GrpE NDUFB10 PF10249.9 EKX73493.1 - 0.47 11.0 4.0 0.68 10.4 0.9 2.1 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase subunit 10 FAINT PF04385.15 EKX73494.1 - 4.6e-06 26.6 0.1 0.0081 16.2 0.0 3.0 2 1 0 2 2 2 2 Domain of unknown function, DUF529 ABC_tran PF00005.27 EKX73495.1 - 3.2e-09 37.4 0.0 5.4e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EKX73495.1 - 0.0073 16.2 0.1 0.014 15.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EKX73495.1 - 0.0098 15.4 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EKX73495.1 - 0.021 14.6 0.2 0.044 13.5 0.2 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Dynamin_N PF00350.23 EKX73495.1 - 0.042 13.9 0.8 0.22 11.6 0.1 2.0 2 0 0 2 2 2 0 Dynamin family AAA_23 PF13476.6 EKX73495.1 - 0.12 12.9 0.8 0.21 12.1 0.8 1.3 1 0 0 1 1 1 0 AAA domain Hydrolase_3 PF08282.12 EKX73497.1 - 2e-40 139.2 0.0 2.5e-40 138.8 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EKX73497.1 - 1.5e-09 37.8 0.0 6.2e-06 25.9 0.0 2.2 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EKX73497.1 - 0.012 15.9 0.0 0.025 14.9 0.0 1.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EKX73497.1 - 0.068 13.3 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase VBS PF08913.10 EKX73498.1 - 0.025 15.0 0.2 0.067 13.7 0.1 1.7 1 1 1 2 2 2 0 Vinculin Binding Site Sipho_Gp157 PF05565.11 EKX73498.1 - 0.027 14.5 0.0 0.076 13.0 0.0 1.7 1 1 1 2 2 2 0 Siphovirus Gp157 FAINT PF04385.15 EKX73500.1 - 9.3e-27 92.9 33.0 4.6e-09 36.2 2.0 8.4 7 2 1 8 8 8 7 Domain of unknown function, DUF529 NOA36 PF06524.12 EKX73503.1 - 0.0062 15.9 0.0 0.0079 15.6 0.0 1.1 1 0 0 1 1 1 1 NOA36 protein AAA_9 PF12781.7 EKX73503.1 - 0.019 14.1 0.7 0.027 13.6 0.7 1.2 1 0 0 1 1 1 0 ATP-binding dynein motor region S-antigen PF05756.11 EKX73503.1 - 0.047 14.1 0.7 0.1 12.9 0.7 1.6 1 0 0 1 1 1 0 S-antigen protein Peptidase_C107 PF17222.3 EKX73503.1 - 0.068 12.1 0.1 0.14 11.1 0.1 1.5 1 1 0 1 1 1 0 Viral cysteine endopeptidase C107 FAINT PF04385.15 EKX73503.1 - 0.16 12.1 1.9 1.1 9.3 0.1 2.5 2 1 1 3 3 3 0 Domain of unknown function, DUF529 ATP11 PF06644.11 EKX73504.1 - 3.5e-27 95.9 0.4 4.9e-27 95.4 0.4 1.1 1 0 0 1 1 1 1 ATP11 protein YrbL-PhoP_reg PF10707.9 EKX73504.1 - 0.13 11.8 0.2 0.59 9.6 0.2 1.8 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL FAINT PF04385.15 EKX73505.1 - 1.3e-07 31.6 0.0 2.1e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 LidA_Long_CC PF18641.1 EKX73506.1 - 0.0056 16.8 0.6 0.0056 16.8 0.6 2.5 3 0 0 3 3 3 1 LidA long coiled-coil domain DUF948 PF06103.11 EKX73506.1 - 0.012 15.8 12.5 1.5 9.1 0.1 4.3 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Yopt PF09467.10 EKX73506.1 - 0.022 14.8 0.1 0.14 12.2 0.1 2.3 1 1 0 1 1 1 0 Hypothetical protein Yopt RecG_N PF17190.4 EKX73506.1 - 0.19 12.5 11.3 0.32 11.7 0.2 3.9 3 1 1 4 4 4 0 RecG N-terminal helical domain KIP1 PF07765.12 EKX73506.1 - 5.3 7.2 7.2 9.4 6.4 0.3 3.7 4 0 0 4 4 4 0 KIP1-like protein Mod_r PF07200.13 EKX73506.1 - 7.5 6.7 19.5 1.7 8.7 0.3 4.0 3 1 0 4 4 4 0 Modifier of rudimentary (Mod(r)) protein FAST_1 PF06743.15 EKX73507.1 - 0.02 14.8 0.0 0.52 10.3 0.0 2.4 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 FAINT PF04385.15 EKX73508.1 - 2.4e-16 59.6 3.6 9.1e-05 22.4 0.0 3.4 3 0 0 3 3 3 3 Domain of unknown function, DUF529 EMA PF02488.15 EKX73508.1 - 0.14 11.8 5.3 0.21 11.3 0.7 2.6 2 1 1 3 3 3 0 Merozoite Antigen FAINT PF04385.15 EKX73510.1 - 3.8e-05 23.7 0.0 5.6e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73513.1 - 2.1e-07 30.9 0.4 3.6e-07 30.2 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function, DUF529 Baculo_RING PF05883.11 EKX73513.1 - 0.045 13.7 0.1 0.069 13.1 0.1 1.3 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain FAINT PF04385.15 EKX73514.1 - 1.6e-13 50.5 1.3 8.3e-07 29.0 0.0 2.6 2 1 0 2 2 2 2 Domain of unknown function, DUF529 Glyco_hydro_32N PF00251.20 EKX73514.1 - 0.0026 17.4 0.0 0.0034 17.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain DUF2510 PF10708.9 EKX73514.1 - 0.11 12.3 0.1 0.21 11.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2510) FAINT PF04385.15 EKX73516.1 - 2e-16 59.8 0.0 1.8e-08 34.3 0.2 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 DehI PF10778.9 EKX73518.1 - 0.11 12.6 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Halocarboxylic acid dehydrogenase DehI SRPRB PF09439.10 EKX73519.1 - 1.5e-21 76.6 0.4 6.6e-21 74.6 0.1 1.8 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit Arf PF00025.21 EKX73519.1 - 7.9e-10 38.5 0.0 1.1e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKX73519.1 - 4.9e-09 36.3 0.0 7.6e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 EKX73519.1 - 6.1e-06 25.9 0.1 1.1e-05 25.1 0.1 1.4 1 1 0 1 1 1 1 Ras family GTP_EFTU PF00009.27 EKX73519.1 - 1.2e-05 24.9 0.3 0.0017 17.9 0.2 2.1 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain Roc PF08477.13 EKX73519.1 - 0.0019 18.4 0.2 0.045 14.0 0.2 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EKX73519.1 - 0.043 13.7 0.4 6.8 6.6 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 EKX73519.1 - 0.061 13.7 0.0 0.14 12.6 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 EKX73519.1 - 0.078 12.7 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 EKX73519.1 - 0.11 12.5 0.1 11 6.1 0.0 2.3 1 1 1 2 2 2 0 Dynamin family FeoB_N PF02421.18 EKX73519.1 - 0.13 11.8 0.1 0.43 10.1 0.1 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B FAINT PF04385.15 EKX73520.1 - 0.016 15.2 0.2 0.035 14.1 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73523.1 - 1.5e-14 53.8 0.9 4.8e-05 23.3 0.0 4.5 4 1 0 4 4 4 3 Domain of unknown function, DUF529 Sugar_transport PF06800.12 EKX73527.1 - 0.22 10.8 0.0 0.35 10.2 0.0 1.2 1 0 0 1 1 1 0 Sugar transport protein FAINT PF04385.15 EKX73528.1 - 3.2e-15 56.0 6.1 3.3e-08 33.5 0.1 4.5 5 0 0 5 5 5 3 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73529.1 - 1.1e-11 44.6 0.0 4e-05 23.6 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73530.1 - 0.0056 16.7 0.2 0.015 15.3 0.0 1.8 1 1 1 2 2 2 1 Domain of unknown function, DUF529 SepRS_C PF18006.1 EKX73530.1 - 0.12 12.5 0.1 0.19 11.9 0.1 1.4 1 0 0 1 1 1 0 O-phosphoseryl-tRNA synthetase C-terminal domain Cbl_N3 PF02762.14 EKX73530.1 - 0.12 12.3 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, SH2-like domain AAA_9 PF12781.7 EKX73532.1 - 0.11 11.7 0.1 0.16 11.1 0.1 1.2 1 0 0 1 1 1 0 ATP-binding dynein motor region Hydrolase_3 PF08282.12 EKX73534.1 - 1.1e-30 107.3 0.0 1.1e-25 90.8 0.0 2.8 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EKX73534.1 - 0.0005 19.7 0.0 0.001 18.6 0.0 1.5 1 0 0 1 1 1 1 Sucrose-6F-phosphate phosphohydrolase FAINT PF04385.15 EKX73534.1 - 0.0027 17.7 3.9 0.041 14.0 0.0 3.7 2 1 0 2 2 2 1 Domain of unknown function, DUF529 Ub-Mut7C PF14451.6 EKX73534.1 - 0.028 14.3 0.0 12 5.8 0.0 3.2 3 0 0 3 3 3 0 Mut7-C ubiquitin Ribosomal_S14 PF00253.21 EKX73536.1 - 1.7e-15 56.5 0.1 3e-15 55.7 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DUF1947 PF09183.10 EKX73537.1 - 0.011 16.1 4.3 2.3 8.6 0.1 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF1947) FAINT PF04385.15 EKX73539.1 - 1e-07 31.9 0.0 1e-07 31.9 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73540.1 - 1.2e-20 73.3 4.5 9.1e-10 38.5 0.1 3.4 3 0 0 3 3 3 3 Domain of unknown function, DUF529 CE2_N PF17996.1 EKX73540.1 - 0.031 14.2 0.1 0.83 9.7 0.0 2.9 3 0 0 3 3 3 0 Carbohydrate esterase 2 N-terminal Pyr_redox_2 PF07992.14 EKX73541.1 - 1.3e-10 41.0 0.0 1.7e-06 27.5 0.0 2.9 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EKX73541.1 - 1.2e-05 25.5 0.0 2.4e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EKX73541.1 - 3.6e-05 24.2 0.4 0.16 12.6 0.0 3.7 4 1 0 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EKX73541.1 - 4.1e-05 23.0 0.0 0.0019 17.5 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.6 EKX73541.1 - 0.0035 17.3 0.0 0.0094 15.9 0.0 1.7 1 0 0 1 1 1 1 FAD-NAD(P)-binding Thi4 PF01946.17 EKX73541.1 - 0.038 13.2 0.0 0.062 12.5 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.14 EKX73541.1 - 0.041 12.7 0.0 0.28 10.0 0.0 1.9 2 0 0 2 2 2 0 Tryptophan halogenase HI0933_like PF03486.14 EKX73541.1 - 0.078 11.7 0.1 0.17 10.6 0.0 1.6 2 0 0 2 2 2 0 HI0933-like protein K_oxygenase PF13434.6 EKX73541.1 - 0.12 11.5 0.0 7.9 5.5 0.0 2.5 3 0 0 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) Coatomer_WDAD PF04053.14 EKX73542.1 - 0.1 11.6 0.0 0.22 10.5 0.0 1.5 1 0 0 1 1 1 0 Coatomer WD associated region Nsp1_C PF05064.13 EKX73542.1 - 5.4 6.9 7.3 8.3 6.3 0.2 3.3 4 0 0 4 4 4 0 Nsp1-like C-terminal region Death PF00531.22 EKX73543.1 - 0.083 13.1 0.4 0.15 12.3 0.4 1.3 1 0 0 1 1 1 0 Death domain FAINT PF04385.15 EKX73544.1 - 4.6e-10 39.4 0.0 9.7e-07 28.8 0.0 2.7 2 1 0 2 2 2 2 Domain of unknown function, DUF529 Hydrolase_4 PF12146.8 EKX73546.1 - 2.4e-05 23.7 0.0 3.1e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX73548.1 - 9.3e-11 41.6 0.3 9.2e-06 25.6 0.3 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 SHOCT PF09851.9 EKX73548.1 - 0.19 11.5 3.0 0.34 10.7 3.0 1.4 1 0 0 1 1 1 0 Short C-terminal domain DNA_pol_alpha_N PF12254.8 EKX73548.1 - 0.19 11.8 1.8 0.37 10.9 1.8 1.4 1 0 0 1 1 1 0 DNA polymerase alpha subunit p180 N terminal Aldo_ket_red PF00248.21 EKX73549.1 - 7.9e-57 192.7 0.0 9.8e-57 192.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family FAINT PF04385.15 EKX73550.1 - 1.8e-17 63.2 0.0 1.7e-10 40.8 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73551.1 - 2.2e-07 30.9 0.3 0.00023 21.1 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73552.1 - 1.5e-12 47.4 2.2 0.00014 21.8 0.0 3.5 3 0 0 3 3 3 3 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73553.1 - 5e-10 39.3 0.1 0.0011 19.0 0.0 2.8 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73554.1 - 1.4e-12 47.4 0.0 9e-07 28.9 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 PP2C PF00481.21 EKX73556.1 - 1e-64 218.7 0.0 1.1e-51 176.0 0.0 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 EKX73556.1 - 0.0022 18.0 0.0 0.017 15.1 0.0 2.1 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) RNase_T PF00929.24 EKX73556.1 - 0.05 14.2 0.0 0.17 12.4 0.0 1.9 2 0 0 2 2 2 0 Exonuclease Cuticle_2 PF08184.11 EKX73558.1 - 0.066 13.2 2.8 3.1 7.9 0.0 3.0 3 0 0 3 3 3 0 Cuticle protein 7 isoform family PIG-F PF06699.11 EKX73559.1 - 1.2e-06 28.8 2.0 2.5e-06 27.8 2.0 1.5 1 1 0 1 1 1 1 GPI biosynthesis protein family Pig-F 2TM PF13239.6 EKX73559.1 - 0.057 13.7 1.0 0.057 13.7 1.0 2.7 2 1 1 3 3 3 0 2TM domain DUF3784 PF12650.7 EKX73559.1 - 0.22 11.7 9.0 3 8.1 1.8 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF3784) CPP1-like PF11833.8 EKX73559.1 - 0.59 9.7 2.8 3.8 7.1 2.8 2.3 1 1 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like ETRAMP PF09716.10 EKX73559.1 - 1.1 9.4 5.6 1.7 8.8 1.4 3.0 3 1 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) GWT1 PF06423.12 EKX73559.1 - 5.4 7.1 10.6 6.8 6.8 2.5 2.5 1 1 2 3 3 3 0 GWT1 FAINT PF04385.15 EKX73560.1 - 7.3e-05 22.8 0.8 0.00011 22.2 0.1 1.7 2 1 0 2 2 2 1 Domain of unknown function, DUF529 DUF2959 PF11172.8 EKX73562.1 - 0.038 14.1 10.7 0.046 13.8 4.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2959) Sigma70_ner PF04546.13 EKX73562.1 - 0.064 13.1 7.1 0.12 12.2 6.3 1.8 1 1 1 2 2 2 0 Sigma-70, non-essential region Allexi_40kDa PF05549.11 EKX73562.1 - 0.11 12.0 9.0 0.26 10.8 1.0 2.3 2 0 0 2 2 2 0 Allexivirus 40kDa protein NYD-SP28_assoc PF14775.6 EKX73562.1 - 0.23 11.6 6.2 0.3 11.2 3.2 2.6 2 0 0 2 2 2 0 Sperm tail C-terminal domain Syntaxin PF00804.25 EKX73562.1 - 0.39 10.4 14.6 1.1 8.9 8.7 2.4 1 1 0 2 2 2 0 Syntaxin Mod_r PF07200.13 EKX73562.1 - 1 9.4 15.4 1 9.5 11.1 3.1 3 1 1 4 4 4 0 Modifier of rudimentary (Mod(r)) protein DUF1664 PF07889.12 EKX73562.1 - 1.1 9.4 5.5 1.1 9.2 3.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Phage_lysis PF03245.13 EKX73562.1 - 1.3 9.1 7.2 1.4 9.1 3.8 2.4 1 1 1 2 2 2 0 Bacteriophage Rz lysis protein COG5 PF10392.9 EKX73562.1 - 2.2 8.4 8.6 7.5 6.7 3.3 2.5 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Fib_alpha PF08702.10 EKX73562.1 - 3.5 7.8 10.2 0.27 11.4 1.4 3.2 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family V-ATPase_G_2 PF16999.5 EKX73562.1 - 5.1 7.6 10.6 3 8.3 7.8 2.0 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit Metallophos PF00149.28 EKX73563.1 - 3.5e-36 125.6 0.2 5.5e-36 125.0 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 EKX73563.1 - 0.007 16.0 0.0 0.01 15.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Metallophos_2 PF12850.7 EKX73563.1 - 0.011 15.9 0.0 0.017 15.3 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain STPPase_N PF16891.5 EKX73563.1 - 0.066 13.7 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Urm1 PF09138.11 EKX73564.1 - 7.2e-27 93.6 0.0 1e-26 93.1 0.0 1.2 1 1 0 1 1 1 1 Urm1 (Ubiquitin related modifier) Guanylate_cyc PF00211.20 EKX73567.1 - 3.7e-81 271.1 0.2 8e-45 152.7 0.0 2.4 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain PhoLip_ATPase_C PF16212.5 EKX73567.1 - 4.1e-30 105.4 26.2 4.1e-30 105.4 26.2 4.9 5 0 0 5 5 5 1 Phospholipid-translocating P-type ATPase C-terminal E1-E2_ATPase PF00122.20 EKX73567.1 - 6.6e-11 42.1 0.3 6.6e-11 42.1 0.3 3.1 2 1 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 EKX73567.1 - 9.7e-06 25.6 0.0 3e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EKX73567.1 - 1e-05 25.9 0.2 0.52 10.6 0.0 3.5 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EKX73567.1 - 0.00018 21.3 0.0 0.00079 19.2 0.0 2.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase PspB PF06667.12 EKX73567.1 - 0.024 14.7 2.5 0.89 9.7 0.0 3.4 3 0 0 3 3 3 0 Phage shock protein B DUF4191 PF13829.6 EKX73567.1 - 1.6 8.0 4.1 1.4 8.2 0.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) Cnd1 PF12717.7 EKX73568.1 - 0.0011 19.1 1.4 0.0061 16.6 0.4 2.7 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EKX73568.1 - 0.0067 15.0 0.2 0.0067 15.0 0.2 2.5 2 1 1 3 3 3 1 Adaptin N terminal region dUTPase_2 PF08761.11 EKX73568.1 - 0.011 15.9 0.1 0.061 13.5 0.1 2.2 1 0 0 1 1 1 0 dUTPase DCB PF16213.5 EKX73568.1 - 0.031 14.0 1.1 0.19 11.4 0.2 2.4 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 VHS PF00790.19 EKX73568.1 - 0.041 13.7 0.2 0.34 10.8 0.0 2.3 2 0 0 2 2 2 0 VHS domain ELMO_CED12 PF04727.13 EKX73569.1 - 4.8e-30 105.0 0.9 9.1e-30 104.1 0.4 1.7 1 1 1 2 2 2 1 ELMO/CED-12 family DUF3417 PF11897.8 EKX73569.1 - 0.008 16.6 0.1 0.019 15.4 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3417) WD40 PF00400.32 EKX73570.1 - 0.0016 19.2 1.3 5.1 8.1 0.0 3.7 3 0 0 3 3 3 2 WD domain, G-beta repeat Nucleoporin_N PF08801.11 EKX73570.1 - 0.007 15.1 1.5 0.14 10.9 0.1 2.4 2 1 1 3 3 3 2 Nup133 N terminal like CBF PF03914.17 EKX73572.1 - 4e-21 75.8 0.2 4e-21 75.8 0.2 2.1 3 0 0 3 3 3 1 CBF/Mak21 family CLASP_N PF12348.8 EKX73572.1 - 0.042 13.4 2.5 0.057 13.0 0.4 2.2 2 0 0 2 2 2 0 CLASP N terminal NOG1 PF06858.14 EKX73573.1 - 1.3e-10 40.9 0.0 5.8e-08 32.4 0.0 3.3 3 0 0 3 3 3 2 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 EKX73573.1 - 3e-10 40.2 0.1 6.8e-09 35.8 0.0 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKX73573.1 - 0.0025 17.4 0.2 0.0075 15.8 0.2 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Roc PF08477.13 EKX73573.1 - 0.021 15.0 0.1 0.073 13.3 0.1 2.0 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 EKX73573.1 - 0.071 12.6 0.1 0.68 9.4 0.0 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B FAINT PF04385.15 EKX73575.1 - 3.8e-11 42.9 0.2 5.5e-11 42.4 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function, DUF529 CG-1 PF03859.16 EKX73575.1 - 0.11 12.3 0.1 0.16 11.8 0.1 1.3 1 0 0 1 1 1 0 CG-1 domain tRNA-synt_1e PF01406.19 EKX73576.1 - 8.1e-122 406.3 0.1 1.5e-121 405.4 0.1 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EKX73576.1 - 1.6e-10 40.3 3.5 4.4e-06 25.7 0.1 2.5 3 0 0 3 3 3 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EKX73576.1 - 6.4e-05 21.4 0.0 0.00014 20.3 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1c PF00749.21 EKX73576.1 - 0.0084 15.0 0.0 0.026 13.4 0.0 1.8 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1f PF01921.18 EKX73576.1 - 0.063 12.2 0.1 0.23 10.4 0.0 1.8 2 0 0 2 2 2 0 tRNA synthetases class I (K) TetR_C_23 PF17931.1 EKX73576.1 - 0.58 10.3 0.0 0.58 10.3 0.0 2.4 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Alba PF01918.21 EKX73579.1 - 6.2e-09 35.5 0.5 8.2e-09 35.2 0.5 1.2 1 0 0 1 1 1 1 Alba Rpp20 PF12328.8 EKX73579.1 - 0.0018 18.2 0.0 0.0021 18.0 0.0 1.2 1 0 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P NOT2_3_5 PF04153.18 EKX73580.1 - 6.1e-31 107.2 2.7 8.2e-31 106.8 2.7 1.2 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family IMP2_N PF18590.1 EKX73581.1 - 1.8e-27 95.7 0.0 3e-27 95.0 0.0 1.4 1 0 0 1 1 1 1 Immune Mapped Protein 2 (IMP2) N-terminal domain VAD1-2 PF15310.6 EKX73581.1 - 0.1 12.5 0.4 0.15 11.9 0.4 1.2 1 0 0 1 1 1 0 Vitamin A-deficiency (VAD) rat model signalling 4HBT PF03061.22 EKX73584.1 - 1.4e-05 25.3 0.0 2.6e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 EKX73584.1 - 0.11 12.6 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4442) DUF5594 PF18057.1 EKX73587.1 - 0.15 11.9 0.0 0.29 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5594) CHCH PF06747.13 EKX73589.1 - 5.2 7.3 11.2 1.4 9.1 6.5 2.5 2 1 0 2 2 2 0 CHCH domain FAINT PF04385.15 EKX73591.1 - 2.5e-12 46.7 0.4 5.3e-07 29.6 0.2 3.2 3 0 0 3 3 3 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73592.1 - 3.2e-09 36.7 1.2 4.9e-06 26.5 0.0 2.8 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Hydrolase_4 PF12146.8 EKX73592.1 - 4.9e-09 35.8 0.1 4.4e-08 32.7 0.0 2.4 2 1 0 2 2 2 1 Serine aminopeptidase, S33 DUF900 PF05990.12 EKX73592.1 - 0.057 12.9 0.0 0.13 11.8 0.0 1.5 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_6 PF12697.7 EKX73592.1 - 0.059 14.0 0.0 0.14 12.8 0.0 1.6 1 1 1 2 2 2 0 Alpha/beta hydrolase family LIP PF03583.14 EKX73593.1 - 0.00029 20.2 0.0 0.00031 20.2 0.0 1.0 1 0 0 1 1 1 1 Secretory lipase Peptidase_S9 PF00326.21 EKX73593.1 - 0.00035 20.1 0.0 0.00041 19.9 0.0 1.0 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EKX73593.1 - 0.01 15.1 0.0 0.012 14.8 0.0 1.1 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EKX73593.1 - 0.06 13.1 0.0 0.061 13.1 0.0 1.1 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase CS PF04969.16 EKX73594.1 - 4.2e-13 50.1 0.1 6.9e-13 49.4 0.1 1.3 1 0 0 1 1 1 1 CS domain NAT PF04768.13 EKX73596.1 - 0.037 13.7 0.2 0.071 12.8 0.2 1.5 1 1 0 1 1 1 0 NAT, N-acetyltransferase, of N-acetylglutamate synthase DUF3449 PF11931.8 EKX73599.1 - 6.1e-74 247.8 1.3 1.2e-73 246.9 1.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 EKX73599.1 - 2.3e-15 56.9 4.0 2.3e-15 56.9 4.0 1.9 2 0 0 2 2 2 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 SF3a60_bindingd PF12108.8 EKX73599.1 - 0.0023 17.7 0.1 0.0063 16.4 0.1 1.8 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain DUF3228 PF11539.8 EKX73600.1 - 0.039 13.5 0.2 0.15 11.6 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3228) FAINT PF04385.15 EKX73601.1 - 7.8e-13 48.3 1.1 3.9e-07 30.0 0.1 2.3 2 0 0 2 2 2 2 Domain of unknown function, DUF529 PLAC9 PF15205.6 EKX73602.1 - 0.0043 17.4 0.4 2.1 8.8 0.0 3.2 2 1 0 2 2 2 2 Placenta-specific protein 9 CTNNBL PF08216.11 EKX73602.1 - 0.31 11.2 3.1 3.7 7.8 0.0 3.6 2 1 2 5 5 5 0 Catenin-beta-like, Arm-motif containing nuclear FAINT PF04385.15 EKX73603.1 - 2.3e-05 24.4 0.2 2.3e-05 24.4 0.2 3.1 2 1 1 3 3 3 2 Domain of unknown function, DUF529 UPF0113_N PF17833.1 EKX73606.1 - 0.077 13.6 0.0 13 6.4 0.0 2.6 2 0 0 2 2 2 0 UPF0113 Pre-PUA domain FAINT PF04385.15 EKX73607.1 - 0.00024 21.1 0.0 0.32 11.1 0.0 2.7 2 1 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73608.1 - 1.8e-16 59.9 3.2 0.00017 21.6 0.0 3.7 3 0 0 3 3 3 3 Domain of unknown function, DUF529 DUF3488 PF11992.8 EKX73609.1 - 0.076 12.0 2.9 0.092 11.7 2.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3488) Pho86 PF11124.8 EKX73609.1 - 0.11 12.0 1.7 0.16 11.4 1.7 1.2 1 0 0 1 1 1 0 Inorganic phosphate transporter Pho86 Smim3 PF17307.2 EKX73609.1 - 5.1 6.7 7.2 0.43 10.1 1.7 2.0 2 0 0 2 2 2 0 Small integral membrane protein 3 Fumerase_C PF05683.12 EKX73611.1 - 5.2e-81 270.9 0.0 9.6e-81 270.0 0.0 1.5 1 0 0 1 1 1 1 Fumarase C-terminus Fumerase PF05681.14 EKX73611.1 - 1.5e-67 227.9 0.0 2.2e-67 227.3 0.0 1.2 1 0 0 1 1 1 1 Fumarate hydratase (Fumerase) CDC45 PF02724.14 EKX73612.1 - 0.077 11.3 2.1 0.11 10.8 2.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Fumerase PF05681.14 EKX73613.1 - 5.6e-07 29.3 0.0 7.7e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Fumarate hydratase (Fumerase) CECR6_TMEM121 PF14997.6 EKX73615.1 - 6e-06 26.2 5.5 0.0029 17.5 0.5 2.8 2 0 0 2 2 2 2 CECR6/TMEM121 family Pilin_N PF07790.11 EKX73616.1 - 0.013 16.4 0.8 0.029 15.3 0.7 1.8 1 1 0 1 1 1 0 Archaeal Type IV pilin, N-terminal DUF1923 PF09083.10 EKX73616.1 - 0.046 13.4 1.0 5.3 6.8 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1923) DUF816 PF05674.12 EKX73616.1 - 0.087 12.7 0.3 0.15 12.0 0.3 1.3 1 0 0 1 1 1 0 Baculovirus protein of unknown function (DUF816) FAINT PF04385.15 EKX73617.1 - 8.1e-12 45.0 9.4 2.5e-05 24.2 0.7 4.6 4 0 0 4 4 4 3 Domain of unknown function, DUF529 Nucleoporin_FG PF13634.6 EKX73618.1 - 0.01 16.7 6.0 0.017 15.9 6.0 1.4 1 1 0 1 1 1 0 Nucleoporin FG repeat region MAGE_N PF12440.8 EKX73622.1 - 0.099 13.3 13.3 0.25 12.1 13.3 1.6 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal FAINT PF04385.15 EKX73624.1 - 2.7e-10 40.2 0.9 1.6e-05 24.8 0.1 2.3 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73625.1 - 0.014 15.4 0.0 0.024 14.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function, DUF529 G-patch_2 PF12656.7 EKX73626.1 - 8.5e-13 48.2 0.4 1.9e-12 47.0 0.4 1.7 1 0 0 1 1 1 1 G-patch domain KN17_SH3 PF18131.1 EKX73626.1 - 0.0036 17.4 0.1 0.018 15.1 0.0 2.2 2 0 0 2 2 2 1 KN17 SH3-like C-terminal domain NdhS PF11623.8 EKX73626.1 - 0.032 13.9 0.0 0.077 12.7 0.0 1.6 1 0 0 1 1 1 0 NAD(P)H dehydrogenase subunit S GCS PF03074.16 EKX73627.1 - 3.9e-108 362.1 0.5 5.4e-108 361.6 0.5 1.2 1 0 0 1 1 1 1 Glutamate-cysteine ligase CdvA PF18822.1 EKX73627.1 - 0.078 12.8 0.0 16 5.3 0.0 2.5 2 0 0 2 2 2 0 CdvA-like coiled-coil domain HTS PF04204.16 EKX73627.1 - 0.079 11.9 0.2 0.18 10.7 0.1 1.6 2 0 0 2 2 2 0 Homoserine O-succinyltransferase DUF913 PF06025.12 EKX73629.1 - 0.55 9.2 1.2 0.75 8.7 1.2 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FAM176 PF14851.6 EKX73629.1 - 0.76 9.4 4.8 1.1 8.9 2.3 2.3 2 0 0 2 2 2 0 FAM176 family DUF1779 PF08680.10 EKX73632.1 - 0.6 10.3 8.8 6.7 6.8 0.4 3.3 3 0 0 3 3 3 0 TATA-box binding Sec20 PF03908.13 EKX73633.1 - 0.1 12.5 0.8 2.7 7.9 0.0 2.6 1 1 1 2 2 2 0 Sec20 DUF3972 PF13118.6 EKX73633.1 - 0.17 12.3 2.5 0.17 12.3 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3972) FAINT PF04385.15 EKX73634.1 - 0.00083 19.4 10.2 0.0028 17.7 2.4 2.5 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Cbl_N2 PF02761.14 EKX73634.1 - 0.16 12.7 0.1 0.34 11.7 0.1 1.5 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, EF hand-like domain FAINT PF04385.15 EKX73635.1 - 1.4e-10 41.0 0.3 5e-05 23.3 0.0 2.8 2 2 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73636.1 - 5.8e-05 23.1 0.0 0.0063 16.6 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73637.1 - 1.1e-47 160.0 12.9 6.2e-05 23.0 0.3 9.6 9 0 0 9 9 9 9 Domain of unknown function, DUF529 Glyco_hydro_79C PF16862.5 EKX73637.1 - 2.2e-05 25.3 0.1 13 6.7 0.0 6.2 6 0 0 6 6 6 1 Glycosyl hydrolase family 79 C-terminal beta domain Phage_attach PF05354.11 EKX73637.1 - 0.15 11.9 0.3 80 3.2 0.0 4.6 6 0 0 6 6 6 0 Phage Head-Tail Attachment Ycf9 PF01737.17 EKX73637.1 - 0.18 11.7 0.1 40 4.2 0.0 3.3 3 0 0 3 3 3 0 YCF9 D5_N PF08706.11 EKX73637.1 - 0.18 12.0 6.1 40 4.4 0.1 6.0 7 1 0 7 7 7 0 D5 N terminal like Hydrolase_4 PF12146.8 EKX73638.1 - 1.2e-17 64.0 0.0 8.4e-17 61.2 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX73638.1 - 1.3e-15 57.2 5.3 6.6e-05 22.9 0.0 4.2 4 0 0 4 4 4 3 Domain of unknown function, DUF529 Peptidase_S9 PF00326.21 EKX73638.1 - 0.0013 18.2 0.0 0.004 16.7 0.0 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family LIP PF03583.14 EKX73638.1 - 0.014 14.7 0.0 0.023 14.1 0.0 1.2 1 0 0 1 1 1 0 Secretory lipase FAINT PF04385.15 EKX73641.1 - 1.9e-24 85.5 0.2 3.9e-08 33.2 0.0 3.3 3 0 0 3 3 3 3 Domain of unknown function, DUF529 DUF4337 PF14235.6 EKX73642.1 - 6.7 6.8 8.2 10 6.2 8.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) FAINT PF04385.15 EKX73645.1 - 2.2e-06 27.6 0.1 2.2e-06 27.6 0.1 3.6 3 1 0 3 3 3 1 Domain of unknown function, DUF529 DUF4566 PF15130.6 EKX73645.1 - 0.13 11.7 0.1 0.21 11.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4566) Hydrolase_4 PF12146.8 EKX73646.1 - 2.1e-18 66.5 0.0 1.4e-16 60.5 0.0 2.9 2 1 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX73646.1 - 1.5e-13 50.6 1.0 0.00036 20.5 0.0 4.0 3 0 0 3 3 3 3 Domain of unknown function, DUF529 Abhydrolase_1 PF00561.20 EKX73646.1 - 0.0016 18.2 0.0 0.0032 17.1 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EKX73646.1 - 0.0035 18.0 0.0 0.0069 17.0 0.0 1.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family AMA-1 PF02430.15 EKX73647.1 - 1.3e-130 436.5 4.4 2.9e-128 428.8 3.4 2.3 1 1 0 1 1 1 1 Apical membrane antigen 1 FAINT PF04385.15 EKX73648.1 - 6.7e-11 42.1 0.0 1.9e-06 27.8 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Atypical_Card PF18461.1 EKX73651.1 - 0.011 16.0 0.1 0.012 15.8 0.1 1.1 1 0 0 1 1 1 0 Atypical caspase recruitment domain HATPase_c_4 PF13749.6 EKX73651.1 - 0.091 12.9 0.0 0.11 12.6 0.0 1.1 1 0 0 1 1 1 0 Putative ATP-dependent DNA helicase recG C-terminal FAINT PF04385.15 EKX73654.1 - 2.4e-12 46.7 1.6 0.0069 16.4 0.1 3.6 3 0 0 3 3 3 3 Domain of unknown function, DUF529 FHA PF00498.26 EKX73656.1 - 1.1e-11 44.9 0.1 4.9e-11 42.8 0.0 2.2 3 0 0 3 3 3 1 FHA domain RRM_1 PF00076.22 EKX73656.1 - 3.6e-11 42.7 0.1 1.3e-10 40.9 0.1 2.1 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1768 PF08719.11 EKX73656.1 - 5.9e-07 29.9 0.0 1.8e-06 28.3 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1768) Nup35_RRM_2 PF14605.6 EKX73656.1 - 1.8e-05 24.6 0.0 4.6e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif FAINT PF04385.15 EKX73658.1 - 2.1e-06 27.7 0.9 2.1e-06 27.7 0.9 1.8 2 1 0 2 2 2 1 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73659.1 - 5.2e-18 64.9 4.3 0.0067 16.5 0.1 5.9 5 1 0 5 5 5 4 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73661.1 - 3e-44 149.0 25.9 8.6e-06 25.7 0.2 9.6 9 0 0 9 9 9 9 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73662.1 - 2.5e-11 43.5 5.2 0.00069 19.6 0.2 3.5 3 0 0 3 3 3 3 Domain of unknown function, DUF529 RNA_pol_Rpc34 PF05158.12 EKX73665.1 - 2.1e-28 99.7 3.7 4.6e-26 92.0 0.3 2.5 1 1 1 2 2 2 2 RNA polymerase Rpc34 subunit Atracotoxin PF05353.11 EKX73666.1 - 0.022 14.8 0.7 0.071 13.2 0.7 1.8 1 0 0 1 1 1 0 Delta Atracotoxin SPC25 PF06703.11 EKX73666.1 - 0.26 11.0 1.4 0.73 9.6 1.4 1.7 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF2583 PF10762.9 EKX73666.1 - 1.5 9.3 4.8 2.4 8.6 0.8 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2583) RecA PF00154.21 EKX73667.1 - 0.074 12.5 0.1 0.12 11.8 0.1 1.3 1 0 0 1 1 1 0 recA bacterial DNA recombination protein FAINT PF04385.15 EKX73668.1 - 0.011 15.7 0.1 0.019 15.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73669.1 - 0.00058 19.9 0.2 0.0013 18.8 0.2 1.7 1 1 1 2 2 2 1 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73670.1 - 5.1e-20 71.3 18.6 7.5e-06 25.9 0.3 4.8 4 0 0 4 4 4 4 Domain of unknown function, DUF529 Tektin PF03148.14 EKX73670.1 - 0.0037 16.1 0.3 0.0073 15.1 0.3 1.4 1 0 0 1 1 1 1 Tektin family TMP_2 PF06791.13 EKX73670.1 - 0.059 13.0 0.7 0.1 12.2 0.7 1.3 1 0 0 1 1 1 0 Prophage tail length tape measure protein YscO-like PF16789.5 EKX73670.1 - 0.21 11.6 6.3 0.86 9.6 6.3 2.0 1 0 0 1 1 1 0 YscO-like protein SesA PF17107.5 EKX73670.1 - 0.23 11.7 3.3 1.5 9.0 1.6 2.5 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Laminin_II PF06009.12 EKX73670.1 - 1 9.4 7.6 4.7 7.2 0.4 4.0 3 1 1 4 4 4 0 Laminin Domain II DUF1664 PF07889.12 EKX73672.1 - 0.12 12.4 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) HEPN_Cthe2314 PF18730.1 EKX73673.1 - 0.017 15.1 1.1 3.1 7.8 0.0 2.7 1 1 2 3 3 3 0 Cthe_2314-like HEPN V-ATPase_G_2 PF16999.5 EKX73673.1 - 0.049 14.0 4.2 0.11 12.9 0.1 2.8 2 1 1 3 3 3 0 Vacuolar (H+)-ATPase G subunit HisKA_3 PF07730.13 EKX73673.1 - 0.073 13.6 2.0 0.66 10.5 0.1 2.8 2 0 0 2 2 2 0 Histidine kinase DUF948 PF06103.11 EKX73673.1 - 0.11 12.8 0.8 0.54 10.5 0.1 2.3 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Apolipoprotein PF01442.18 EKX73673.1 - 0.19 11.6 3.8 3.7 7.4 3.8 2.2 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF1664 PF07889.12 EKX73673.1 - 0.57 10.2 3.9 0.59 10.2 0.3 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF883 PF05957.13 EKX73673.1 - 1.5 9.4 4.0 26 5.5 0.4 2.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) FAINT PF04385.15 EKX73674.1 - 3.6e-15 55.8 0.8 9.9e-10 38.3 0.2 2.5 2 1 0 2 2 2 2 Domain of unknown function, DUF529 AviRa PF11599.8 EKX73674.1 - 0.073 12.5 0.1 0.11 11.9 0.1 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa OST3_OST6 PF04756.13 EKX73676.1 - 3.5e-09 36.4 0.2 0.012 15.0 0.0 3.1 3 0 0 3 3 3 3 OST3 / OST6 family, transporter family DUF2208 PF09973.9 EKX73676.1 - 0.058 13.0 0.2 0.12 11.9 0.2 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) DUF61 PF01886.16 EKX73677.1 - 0.078 13.0 0.4 0.22 11.5 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function DUF61 FAINT PF04385.15 EKX73678.1 - 2.2e-17 62.9 4.0 8.1e-08 32.2 0.0 3.5 3 0 0 3 3 3 3 Domain of unknown function, DUF529 DNA_pol3_delt_C PF14840.6 EKX73678.1 - 0.15 12.4 0.0 0.26 11.6 0.0 1.3 1 0 0 1 1 1 0 Processivity clamp loader gamma complex DNA pol III C-term Ribosomal_S25 PF03297.15 EKX73679.1 - 3.4e-36 123.5 5.7 3.7e-36 123.4 5.7 1.0 1 0 0 1 1 1 1 S25 ribosomal protein MarR PF01047.22 EKX73679.1 - 0.052 13.5 0.2 0.091 12.7 0.2 1.3 1 0 0 1 1 1 0 MarR family PheRS_DBD3 PF18553.1 EKX73679.1 - 0.58 10.5 5.9 0.38 11.1 3.5 1.9 2 1 0 2 2 2 0 PheRS DNA binding domain 3 Flavodoxin_1 PF00258.25 EKX73680.1 - 0.11 12.7 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Flavodoxin DUF2510 PF10708.9 EKX73680.1 - 0.13 12.0 0.1 0.27 11.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2510) Ribosomal_L1 PF00687.21 EKX73681.1 - 1.2e-15 57.8 0.0 4.4e-15 56.0 0.0 1.9 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family GntP_permease PF02447.16 EKX73681.1 - 0.23 10.1 0.0 0.33 9.6 0.0 1.1 1 0 0 1 1 1 0 GntP family permease P22_portal PF16510.5 EKX73683.1 - 0.097 11.3 0.1 0.16 10.6 0.1 1.2 1 0 0 1 1 1 0 Phage P22-like portal protein zf-RING_2 PF13639.6 EKX73684.1 - 3.5e-08 33.7 11.9 3.5e-08 33.7 11.9 3.0 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 EKX73684.1 - 2.2e-07 30.6 14.0 5.7e-07 29.3 9.7 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EKX73684.1 - 3.9e-06 27.1 12.6 4.9e-05 23.5 12.6 2.5 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EKX73684.1 - 1.9e-05 24.4 12.9 2.4e-05 24.1 9.6 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EKX73684.1 - 0.00035 20.4 7.3 0.00035 20.4 7.3 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EKX73684.1 - 0.0027 17.5 8.2 0.0027 17.5 8.2 2.5 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EKX73684.1 - 0.0081 16.2 7.9 0.0081 16.2 7.9 2.3 3 0 0 3 3 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EKX73684.1 - 0.013 15.6 12.7 0.038 14.2 8.7 2.8 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 EKX73684.1 - 0.017 15.0 4.6 0.057 13.3 4.6 1.9 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 EKX73684.1 - 0.1 12.7 7.4 1 9.5 7.4 2.5 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 EKX73684.1 - 0.15 12.3 8.6 1.4 9.2 8.6 2.7 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_11 PF17123.5 EKX73684.1 - 1.1 9.0 12.5 0.15 11.8 7.2 2.5 2 0 0 2 2 2 0 RING-like zinc finger zf-HC5HC2H PF13771.6 EKX73684.1 - 3.5 8.0 7.3 0.7 10.2 1.7 2.4 2 0 0 2 2 2 0 PHD-like zinc-binding domain Zn_ribbon_17 PF17120.5 EKX73684.1 - 5.1 6.8 15.8 0.053 13.2 7.0 2.3 3 0 0 3 3 2 0 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 EKX73684.1 - 5.7 7.3 14.6 2.7 8.4 9.1 2.6 2 0 0 2 2 2 0 RING-like domain zf-RING_5 PF14634.6 EKX73684.1 - 7.5 6.6 19.1 0.045 13.7 9.4 2.5 3 0 0 3 3 2 0 zinc-RING finger domain DUF5499 PF17603.2 EKX73687.1 - 0.087 13.4 0.0 3.9 8.2 0.0 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5499) Nrap_D4 PF17405.2 EKX73688.1 - 7.6e-26 90.8 0.0 1.6e-25 89.8 0.0 1.4 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D3 PF17404.2 EKX73688.1 - 8.6e-18 64.9 0.0 2.9e-17 63.2 0.0 1.9 2 0 0 2 2 2 1 Nrap protein domain 3 Nrap_D5 PF17406.2 EKX73688.1 - 5.5e-15 55.5 0.0 2.2e-13 50.3 0.0 2.4 2 0 0 2 2 2 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D2 PF17403.2 EKX73688.1 - 3e-11 43.3 0.0 3.7e-08 33.3 0.1 2.6 2 0 0 2 2 2 2 Nrap protein PAP/OAS-like domain DUF4600 PF15372.6 EKX73689.1 - 0.0048 17.3 1.4 0.011 16.2 1.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4600) FAINT PF04385.15 EKX73691.1 - 1.9e-86 284.2 91.6 5.9e-07 29.5 1.2 23.0 23 0 0 23 23 23 20 Domain of unknown function, DUF529 Viral_P18 PF04521.13 EKX73691.1 - 0.008 16.0 0.0 0.022 14.5 0.0 1.7 1 0 0 1 1 1 1 ssRNA positive strand viral 18kD cysteine rich protein DUF346 PF03984.13 EKX73691.1 - 0.18 11.6 0.0 5.5 6.8 0.0 2.5 2 0 0 2 2 2 0 Repeat of unknown function (DUF346) PSP1 PF04468.12 EKX73691.1 - 0.81 10.0 3.1 8.3 6.8 0.1 3.4 3 0 0 3 3 3 0 PSP1 C-terminal conserved region ABC_tran PF00005.27 EKX73692.1 - 6.3e-30 104.5 0.0 2.5e-16 60.4 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EKX73692.1 - 9.5e-07 28.7 17.1 9.5e-07 28.7 17.1 3.2 3 0 0 3 3 3 1 ABC transporter transmembrane region AAA_16 PF13191.6 EKX73692.1 - 1.2e-05 25.7 0.0 0.074 13.4 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EKX73692.1 - 0.00016 21.4 1.5 0.11 12.2 0.1 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_30 PF13604.6 EKX73692.1 - 0.00021 21.1 0.1 0.24 11.1 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 EKX73692.1 - 0.00041 20.3 0.6 0.15 11.9 0.0 2.9 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EKX73692.1 - 0.00058 19.8 0.8 0.046 13.6 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase FtsK_SpoIIIE PF01580.18 EKX73692.1 - 0.003 17.0 0.3 0.45 9.8 0.0 2.2 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_22 PF13401.6 EKX73692.1 - 0.0031 17.8 0.0 1.1 9.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 EKX73692.1 - 0.0035 16.4 0.3 0.0085 15.1 0.0 1.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 EKX73692.1 - 0.0046 16.3 0.3 0.58 9.4 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin T2SSE PF00437.20 EKX73692.1 - 0.0053 15.8 0.6 2.8 6.9 0.1 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_23 PF13476.6 EKX73692.1 - 0.006 17.1 5.1 0.95 9.9 1.2 2.8 3 0 0 3 3 2 2 AAA domain AAA_18 PF13238.6 EKX73692.1 - 0.011 16.3 0.1 2.9 8.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 EKX73692.1 - 0.016 15.3 3.2 0.18 11.9 0.1 2.8 3 0 0 3 3 2 0 Helicase HerA, central domain MMR_HSR1 PF01926.23 EKX73692.1 - 0.021 14.9 1.5 0.19 11.8 0.0 2.7 3 0 0 3 3 2 0 50S ribosome-binding GTPase SMC_N PF02463.19 EKX73692.1 - 0.023 14.1 0.8 0.23 10.9 0.1 2.5 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain DnaB_C PF03796.15 EKX73692.1 - 0.024 14.0 0.0 0.58 9.4 0.0 2.2 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain NACHT PF05729.12 EKX73692.1 - 0.037 13.9 0.7 6.8 6.6 0.2 2.5 2 0 0 2 2 2 0 NACHT domain AAA_15 PF13175.6 EKX73692.1 - 0.054 13.2 0.5 2.3 7.8 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain SbcCD_C PF13558.6 EKX73692.1 - 0.058 13.6 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit ATPase_2 PF01637.18 EKX73692.1 - 0.087 12.7 0.0 15 5.4 0.0 2.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 EKX73692.1 - 0.097 12.4 0.4 3.3 7.4 0.0 3.0 4 0 0 4 4 3 0 IstB-like ATP binding protein AAA_25 PF13481.6 EKX73692.1 - 0.11 12.0 0.1 2.8 7.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 EKX73692.1 - 0.12 12.1 0.5 9.2 6.0 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein cobW PF02492.19 EKX73692.1 - 0.16 11.6 1.1 16 5.1 0.2 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 EKX73692.1 - 0.16 11.1 1.7 1 8.5 0.0 2.5 3 0 0 3 3 2 0 NB-ARC domain AAA_33 PF13671.6 EKX73692.1 - 0.32 11.2 0.7 21 5.2 0.1 2.9 3 0 0 3 3 2 0 AAA domain Dynamin_N PF00350.23 EKX73692.1 - 0.42 10.6 2.2 25 4.9 0.1 2.9 3 0 0 3 3 3 0 Dynamin family FAINT PF04385.15 EKX73693.1 - 9.9e-16 57.6 9.2 3e-05 24.0 0.3 4.2 3 2 2 5 5 5 3 Domain of unknown function, DUF529 adh_short PF00106.25 EKX73694.1 - 8.3e-33 113.5 0.0 1.3e-24 86.7 0.0 2.0 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EKX73694.1 - 6.6e-18 65.1 0.0 2.3e-17 63.4 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EKX73694.1 - 0.00017 21.6 0.0 0.0088 16.0 0.0 2.3 2 0 0 2 2 2 1 KR domain DUF1776 PF08643.10 EKX73694.1 - 0.0055 16.1 0.0 0.023 14.1 0.0 1.8 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) UCR_6-4kD PF08997.10 EKX73695.1 - 0.018 14.9 0.1 0.027 14.4 0.1 1.3 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein COX14 PF14880.6 EKX73695.1 - 0.033 14.0 0.2 0.047 13.5 0.2 1.3 1 0 0 1 1 1 0 Cytochrome oxidase c assembly Dynamin_N PF00350.23 EKX73696.1 - 1.8e-12 47.6 0.0 5.8e-12 46.0 0.0 1.9 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EKX73696.1 - 0.00068 19.7 0.0 0.0023 18.0 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF4795 PF16043.5 EKX73696.1 - 0.48 10.0 4.5 0.35 10.4 2.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) GDPD PF03009.17 EKX73697.1 - 1.4e-14 54.5 0.0 1.1e-12 48.2 0.0 2.4 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family PAX PF00292.18 EKX73697.1 - 0.0068 16.3 0.0 0.072 13.0 0.0 2.2 2 0 0 2 2 2 1 'Paired box' domain DUF433 PF04255.14 EKX73697.1 - 0.0083 16.0 0.0 3.2 7.7 0.0 3.3 3 0 0 3 3 3 1 Protein of unknown function (DUF433) Adap_comp_sub PF00928.21 EKX73698.1 - 2.6e-49 168.0 0.1 3.5e-49 167.6 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Methyltransf_15 PF09445.10 EKX73699.1 - 6.9e-24 84.3 0.0 1.4e-23 83.2 0.0 1.5 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase RNA_GG_bind PF10258.9 EKX73699.1 - 1.2e-06 28.5 0.0 2.4e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 PHAX RNA-binding domain Methyltransf_23 PF13489.6 EKX73699.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain VASt PF16016.5 EKX73700.1 - 1.4e-13 51.6 0.3 2.7e-13 50.6 0.3 1.5 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EKX73700.1 - 1.1e-07 31.7 1.6 7e-07 29.1 0.2 2.8 2 0 0 2 2 2 1 GRAM domain MAP70 PF07058.11 EKX73700.1 - 0.2 10.3 0.9 0.33 9.7 0.9 1.2 1 0 0 1 1 1 0 Microtubule-associated protein 70 Ribosomal_S18 PF01084.20 EKX73701.1 - 4.9e-16 58.7 0.1 1.5e-15 57.1 0.1 1.8 1 0 0 1 1 1 1 Ribosomal protein S18 DUF327 PF03885.13 EKX73701.1 - 1.9 8.4 6.2 0.73 9.8 2.7 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF327) PDEase_I PF00233.19 EKX73702.1 - 1.3e-60 205.1 0.5 5.3e-60 203.1 0.0 1.9 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase DnaJ PF00226.31 EKX73703.1 - 2.1e-28 98.3 1.4 3e-28 97.7 1.4 1.3 1 0 0 1 1 1 1 DnaJ domain RPT PF13446.6 EKX73703.1 - 0.026 14.4 0.0 0.053 13.4 0.0 1.5 1 0 0 1 1 1 0 A repeated domain in UCH-protein MCM PF00493.23 EKX73704.1 - 5.9e-74 247.9 0.0 8.2e-74 247.5 0.0 1.1 1 0 0 1 1 1 1 MCM P-loop domain Mg_chelatase PF01078.21 EKX73704.1 - 2.4e-09 36.9 0.1 2.6e-06 27.0 0.1 2.6 2 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EKX73704.1 - 2.7e-08 33.7 0.0 5.8e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EKX73704.1 - 4.5e-08 33.2 0.0 1.2e-07 31.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 EKX73704.1 - 4.9e-07 30.2 0.0 9.5e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EKX73704.1 - 4.7e-06 26.4 0.0 0.0042 16.8 0.0 2.3 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_16 PF13191.6 EKX73704.1 - 0.006 17.0 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain MCM_OB PF17207.3 EKX73704.1 - 0.013 15.4 0.1 0.4 10.5 0.1 2.3 1 1 0 1 1 1 0 MCM OB domain AAA_2 PF07724.14 EKX73704.1 - 0.016 15.3 0.0 0.028 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EKX73704.1 - 0.027 14.2 0.0 0.18 11.5 0.0 2.2 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain MMR_HSR1 PF01926.23 EKX73704.1 - 0.028 14.5 0.1 0.37 10.9 0.1 2.7 2 1 0 2 2 2 0 50S ribosome-binding GTPase NACHT PF05729.12 EKX73704.1 - 0.088 12.7 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 NACHT domain Glyco_trans_4_3 PF12000.8 EKX73704.1 - 0.14 11.9 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 4 group Amino_oxidase PF01593.24 EKX73706.1 - 6.8e-44 150.9 0.0 3.1e-31 109.2 0.0 2.7 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EKX73706.1 - 3.6e-12 46.3 0.1 8e-12 45.2 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EKX73706.1 - 1.2e-07 31.2 0.2 2e-07 30.5 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EKX73706.1 - 2.8e-06 27.0 0.3 4.7e-06 26.2 0.3 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 EKX73706.1 - 4.1e-06 26.6 0.0 8.6e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EKX73706.1 - 4.2e-06 26.2 0.1 9.5e-06 25.0 0.1 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 EKX73706.1 - 1.2e-05 24.7 0.0 2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EKX73706.1 - 3.6e-05 23.2 1.2 6.2e-05 22.4 1.2 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EKX73706.1 - 0.00016 22.2 0.6 0.0012 19.4 0.1 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EKX73706.1 - 0.0014 17.8 0.2 0.0023 17.1 0.2 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A HI0933_like PF03486.14 EKX73706.1 - 0.0014 17.4 0.2 0.0034 16.2 0.2 1.6 2 0 0 2 2 2 1 HI0933-like protein Lycopene_cycl PF05834.12 EKX73706.1 - 0.0015 17.7 0.1 0.0022 17.1 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 EKX73706.1 - 0.014 14.7 0.2 0.026 13.8 0.2 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Trp_halogenase PF04820.14 EKX73706.1 - 0.12 11.2 0.2 0.19 10.6 0.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase zf-HC5HC2H PF13771.6 EKX73706.1 - 0.22 11.8 6.0 0.64 10.3 6.0 1.7 1 0 0 1 1 1 0 PHD-like zinc-binding domain MCM PF00493.23 EKX73707.1 - 5e-94 313.6 0.4 9.3e-94 312.7 0.4 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EKX73707.1 - 6.7e-29 100.3 0.4 1.3e-28 99.4 0.4 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EKX73707.1 - 1.6e-25 89.3 1.0 3.7e-25 88.2 1.0 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EKX73707.1 - 3.5e-07 29.8 0.0 2.4e-06 27.1 0.0 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_lid_7 PF17867.1 EKX73707.1 - 0.0034 17.5 1.2 0.058 13.6 0.3 2.5 2 0 0 2 2 2 1 Midasin AAA lid domain AAA_5 PF07728.14 EKX73707.1 - 0.007 16.4 0.0 0.02 14.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EKX73707.1 - 0.0077 16.0 0.0 0.02 14.6 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.11 EKX73707.1 - 0.026 14.4 0.0 0.061 13.2 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MCM_N PF14551.6 EKX73707.1 - 0.44 11.2 3.7 44 4.7 3.7 2.9 1 1 0 1 1 1 0 MCM N-terminal domain ubiquitin PF00240.23 EKX73708.1 - 6.9e-71 234.0 4.2 1.1e-34 117.9 0.3 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EKX73708.1 - 9.4e-35 118.3 4.6 1.2e-16 60.3 0.4 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EKX73708.1 - 6.2e-14 52.2 0.8 3.1e-05 24.3 0.1 3.2 2 2 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 EKX73708.1 - 1.8e-08 34.2 0.3 0.0068 16.3 0.1 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EKX73708.1 - 5.8e-08 33.0 0.3 0.013 15.8 0.0 2.1 1 1 1 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EKX73708.1 - 6.3e-08 32.7 0.3 0.02 15.0 0.0 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EKX73708.1 - 7.1e-06 26.5 0.0 0.11 13.0 0.0 2.2 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EKX73708.1 - 4.8e-05 23.3 6.8 9.2 6.4 0.0 4.0 4 0 0 4 4 4 2 Ubiquitin-like domain Sde2_N_Ubi PF13019.6 EKX73708.1 - 0.00024 21.0 0.0 0.65 9.8 0.0 2.1 1 1 1 2 2 2 2 Silencing defective 2 N-terminal ubiquitin domain DUF2870 PF11069.8 EKX73708.1 - 0.013 15.8 0.1 11 6.5 0.0 2.8 2 2 2 4 4 4 0 Protein of unknown function (DUF2870) RBD PF02196.15 EKX73708.1 - 0.028 14.5 0.0 11 6.2 0.0 2.4 2 0 0 2 2 2 0 Raf-like Ras-binding domain FERM_f0 PF16511.5 EKX73708.1 - 0.046 14.0 2.0 32 4.9 0.1 3.7 2 2 0 2 2 2 0 N-terminal or F0 domain of Talin-head FERM DUF3861 PF12977.7 EKX73708.1 - 0.046 13.9 0.1 11 6.2 0.0 2.2 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) FlgD_ig PF13860.6 EKX73708.1 - 0.11 12.4 0.5 21 5.1 0.1 2.4 2 0 0 2 2 2 0 FlgD Ig-like domain TmoB PF06234.12 EKX73708.1 - 0.11 12.6 0.3 25 5.0 0.0 2.7 2 2 0 2 2 2 0 Toluene-4-monooxygenase system protein B (TmoB) UDP-g_GGTase PF06427.11 EKX73708.1 - 0.14 12.3 0.5 1.6 8.9 0.0 2.4 3 0 0 3 3 3 0 UDP-glucose:Glycoprotein Glucosyltransferase DUF969 PF06149.12 EKX73708.1 - 0.15 11.4 0.0 6.4 6.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF969) E1-E2_ATPase PF00122.20 EKX73709.1 - 4e-46 156.8 4.4 4e-46 156.8 4.4 3.0 5 0 0 5 5 5 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EKX73709.1 - 3.1e-34 118.3 0.4 2.1e-33 115.5 0.1 2.4 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EKX73709.1 - 1.2e-19 71.5 0.8 7.9e-07 29.6 0.0 3.9 4 1 0 4 4 4 3 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EKX73709.1 - 4.4e-17 61.5 0.1 1.4e-16 59.9 0.0 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EKX73709.1 - 1.8e-11 43.9 0.0 5.9e-11 42.3 0.0 1.9 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EKX73709.1 - 0.00054 19.8 1.4 0.018 14.8 0.8 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EKX73709.1 - 0.19 12.1 0.0 0.71 10.2 0.0 1.9 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase AzlD PF05437.12 EKX73709.1 - 0.46 10.7 6.8 0.16 12.2 1.1 2.5 2 0 0 2 2 2 0 Branched-chain amino acid transport protein (AzlD) TAF1D PF15333.6 EKX73710.1 - 0.0058 16.4 0.1 0.011 15.5 0.1 1.3 1 0 0 1 1 1 1 TATA box-binding protein-associated factor 1D AKAP7_RIRII_bdg PF10470.9 EKX73710.1 - 0.014 15.5 0.0 0.029 14.4 0.0 1.5 1 0 0 1 1 1 0 PKA-RI-RII subunit binding domain of A-kinase anchor protein Peptidase_S3 PF00944.19 EKX73710.1 - 0.098 12.5 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Alphavirus core protein GCFC PF07842.12 EKX73712.1 - 2.1e-14 53.8 1.3 7e-13 48.8 0.1 2.4 2 0 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 EKX73712.1 - 7.1e-10 38.6 4.3 7.1e-10 38.6 4.3 1.9 2 0 0 2 2 2 1 G-patch domain HALZ PF02183.18 EKX73712.1 - 0.00018 21.7 0.3 0.00057 20.1 0.1 2.0 2 0 0 2 2 2 1 Homeobox associated leucine zipper TIP_N PF12457.8 EKX73712.1 - 0.076 13.4 8.6 1.8 9.0 8.6 2.6 1 1 0 1 1 1 0 Tuftelin interacting protein N terminal G-patch_2 PF12656.7 EKX73712.1 - 3.1 7.9 4.5 1.1 9.4 1.3 1.9 2 0 0 2 2 2 0 G-patch domain Ribosomal_S16 PF00886.19 EKX73713.1 - 2.8e-11 43.3 0.0 1.3e-10 41.2 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein S16 TPT PF03151.16 EKX73714.1 - 1.8e-65 221.2 16.7 4.7e-65 219.8 16.7 1.6 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EKX73714.1 - 2.4e-08 34.2 16.4 0.00011 22.4 3.7 2.8 3 0 0 3 3 3 2 EamA-like transporter family UAA PF08449.11 EKX73714.1 - 1.4 8.1 13.1 2.3 7.4 13.1 1.4 1 1 0 1 1 1 0 UAA transporter family Adap_comp_sub PF00928.21 EKX73716.1 - 1.6e-81 273.6 0.6 2e-81 273.3 0.6 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EKX73716.1 - 5.6e-07 29.6 1.7 9.7e-07 28.8 1.7 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain AAA PF00004.29 EKX73717.1 - 1.4e-40 138.8 0.0 2.7e-40 137.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EKX73717.1 - 9.2e-10 38.2 0.1 2.1e-09 37.0 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EKX73717.1 - 1.5e-05 25.3 0.1 0.0096 16.2 0.0 2.6 1 1 1 2 2 2 2 AAA domain AAA_5 PF07728.14 EKX73717.1 - 3.7e-05 23.7 0.0 0.00011 22.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EKX73717.1 - 6.8e-05 23.3 0.1 0.0026 18.2 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 EKX73717.1 - 0.00043 20.4 0.0 0.00092 19.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EKX73717.1 - 0.00081 19.2 0.0 0.0017 18.1 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 EKX73717.1 - 0.0036 16.5 0.0 0.006 15.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 EKX73717.1 - 0.01 16.4 0.0 0.023 15.2 0.0 1.7 2 0 0 2 2 1 0 AAA domain AAA_28 PF13521.6 EKX73717.1 - 0.013 15.8 0.0 0.019 15.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EKX73717.1 - 0.014 14.9 0.0 0.045 13.3 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 EKX73717.1 - 0.031 14.5 0.0 0.055 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EKX73717.1 - 0.034 13.9 0.0 0.14 11.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 EKX73717.1 - 0.035 13.9 0.0 0.061 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EKX73717.1 - 0.05 14.0 0.0 0.19 12.1 0.0 2.0 2 0 0 2 2 2 0 RNA helicase Mg_chelatase PF01078.21 EKX73717.1 - 0.069 12.5 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 EKX73717.1 - 0.11 12.4 0.0 8.2 6.3 0.0 2.3 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 EKX73717.1 - 0.18 11.6 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF1492 PF07374.11 EKX73718.1 - 0.18 12.0 2.4 0.25 11.5 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1492) RPN1_RPN2_N PF17781.1 EKX73719.1 - 5.7e-49 167.2 3.4 8.1e-49 166.7 3.4 1.2 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 EKX73719.1 - 9.2e-24 83.2 0.1 1.9e-23 82.2 0.1 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 EKX73719.1 - 2.4e-18 65.6 13.0 0.027 14.9 0.6 8.0 8 0 0 8 8 8 5 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EKX73719.1 - 1.8e-06 28.2 0.0 0.00053 20.3 0.0 3.9 3 1 2 5 5 5 1 HEAT repeats eIF2A PF08662.11 EKX73721.1 - 1.5e-65 220.7 0.0 1.7e-64 217.3 0.0 2.1 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A DnaJ_C PF01556.18 EKX73722.1 - 1.6e-38 132.1 0.0 4.6e-38 130.6 0.0 1.7 1 1 1 2 2 2 1 DnaJ C terminal domain DnaJ PF00226.31 EKX73722.1 - 1.9e-23 82.4 2.3 3.1e-23 81.7 2.3 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EKX73722.1 - 1.2e-14 54.4 19.9 2.3e-14 53.5 19.9 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EKX73722.1 - 0.022 14.7 4.1 0.022 14.7 4.1 2.6 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EKX73722.1 - 1.1 9.3 11.0 3.8 7.6 0.5 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Cytochrome_CBB3 PF13442.6 EKX73722.1 - 1.6 9.1 4.2 1.2 9.5 0.7 2.7 1 1 1 2 2 2 0 Cytochrome C oxidase, cbb3-type, subunit III A2L_zn_ribbon PF08792.10 EKX73722.1 - 2.1 8.2 16.3 18 5.2 0.1 4.4 4 0 0 4 4 4 0 A2L zinc ribbon domain DUF1258 PF06869.12 EKX73722.1 - 2.5 7.5 6.9 0.52 9.7 3.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1258) DZR PF12773.7 EKX73722.1 - 5.5 7.1 12.6 80 3.4 1.5 2.4 1 1 1 2 2 2 0 Double zinc ribbon HEAT_2 PF13646.6 EKX73723.1 - 9.9e-25 86.8 0.0 1.1e-10 41.7 0.0 3.1 2 1 1 3 3 3 3 HEAT repeats HEAT_PBS PF03130.16 EKX73723.1 - 6.6e-17 60.4 0.2 0.002 18.6 0.0 7.1 7 0 0 7 7 7 3 PBS lyase HEAT-like repeat HEAT PF02985.22 EKX73723.1 - 7.5e-12 44.4 2.3 0.0042 17.2 0.0 5.6 6 0 0 6 6 6 4 HEAT repeat HEAT_EZ PF13513.6 EKX73723.1 - 3.8e-06 27.3 0.0 0.32 11.5 0.0 3.9 3 1 0 3 3 3 2 HEAT-like repeat Cnd1 PF12717.7 EKX73723.1 - 0.00028 20.9 1.6 0.61 10.1 0.1 2.8 2 2 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 EKX73723.1 - 0.00049 20.0 0.2 0.31 11.1 0.0 3.9 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat zf-CCCH_6 PF18585.1 EKX73723.1 - 0.015 15.1 0.2 2.9 7.8 0.0 2.9 2 0 0 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 zf-TRAF_2 PF15965.5 EKX73723.1 - 0.059 13.8 0.6 0.26 11.8 0.0 2.1 2 0 0 2 2 2 0 TRAF-like zinc-finger RAP-1 PF03085.15 EKX73724.1 - 3.4e-116 387.1 26.0 1.2e-41 143.0 11.1 3.1 1 1 2 3 3 3 3 Rhoptry-associated protein 1 (RAP-1) DUF2533 PF10752.9 EKX73724.1 - 8.8e-05 22.9 0.1 1.9 9.0 0.0 3.9 3 0 0 3 3 3 2 Protein of unknown function (DUF2533) SpoVG PF04026.12 EKX73724.1 - 0.0031 17.7 0.0 4.8 7.4 0.0 3.5 4 0 0 4 4 4 2 SpoVG MHB PF16525.5 EKX73724.1 - 0.034 14.4 0.0 8.6 6.7 0.0 3.1 2 0 0 2 2 2 0 Haemophore, haem-binding PIF6 PF05341.11 EKX73724.1 - 0.24 11.5 3.7 13 6.0 0.2 3.0 3 0 0 3 3 3 0 Per os infectivity factor 6 RAP-1 PF03085.15 EKX73725.1 - 8.5e-89 297.4 8.4 6.9e-54 183.1 3.9 2.3 1 1 1 2 2 2 2 Rhoptry-associated protein 1 (RAP-1) Ribosomal_L18 PF17135.4 EKX73725.1 - 0.036 13.5 0.0 0.43 9.9 0.0 2.4 2 0 0 2 2 2 0 Ribosomal protein 60S L18 and 50S L18e PP28 PF10252.9 EKX73726.1 - 3.7e-13 49.7 22.7 1.3e-12 48.0 22.7 2.1 1 1 0 1 1 1 1 Casein kinase substrate phosphoprotein PP28 DUF2407 PF10302.9 EKX73726.1 - 0.23 12.0 5.7 0.079 13.5 2.6 1.8 1 1 1 2 2 2 0 DUF2407 ubiquitin-like domain Nop53 PF07767.11 EKX73726.1 - 0.33 10.3 26.5 0.38 10.1 26.5 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) POX PF07526.11 EKX73726.1 - 0.64 10.6 11.5 1 9.9 11.5 1.4 1 1 0 1 1 1 0 Associated with HOX CAML PF14963.6 EKX73726.1 - 1.7 8.7 14.2 2 8.5 14.2 1.0 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand NAM-associated PF14303.6 EKX73726.1 - 2.5 8.8 18.2 3.3 8.4 18.2 1.3 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain CSRNP_N PF16019.5 EKX73726.1 - 4.3 7.2 11.9 0.88 9.4 8.4 1.5 1 1 1 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus DUF2207 PF09972.9 EKX73727.1 - 0.064 12.0 1.3 0.072 11.8 0.4 1.5 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) SNARE PF05739.19 EKX73727.1 - 0.066 13.2 0.4 0.066 13.2 0.4 2.1 2 0 0 2 2 2 0 SNARE domain FYVE_2 PF02318.16 EKX73727.1 - 0.15 12.3 0.1 0.3 11.3 0.1 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger Baculo_11_kDa PF06143.11 EKX73727.1 - 2.5 7.7 6.6 6 6.5 6.6 1.7 1 1 0 1 1 1 0 Baculovirus 11 kDa family Fib_alpha PF08702.10 EKX73727.1 - 3.1 8.0 5.5 5.8 7.1 1.0 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Helicase_C PF00271.31 EKX73728.1 - 2.3e-13 50.4 0.1 2.4e-11 44.0 0.1 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HA2 PF04408.23 EKX73728.1 - 1.9e-08 34.6 0.0 4.7e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) DEAD PF00270.29 EKX73728.1 - 0.00021 21.1 0.1 0.0018 18.1 0.1 2.2 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EKX73728.1 - 0.00021 21.6 0.0 0.00055 20.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EKX73728.1 - 0.001 18.4 0.0 0.0028 17.0 0.0 1.7 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) ATPase PF06745.13 EKX73728.1 - 0.0073 15.7 0.4 0.019 14.3 0.2 1.7 2 0 0 2 2 2 1 KaiC ResIII PF04851.15 EKX73728.1 - 0.0097 15.9 0.1 0.19 11.7 0.0 2.8 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_29 PF13555.6 EKX73728.1 - 0.015 15.1 0.2 0.048 13.4 0.0 2.0 2 0 0 2 2 1 0 P-loop containing region of AAA domain PhoH PF02562.16 EKX73728.1 - 0.036 13.5 0.1 0.095 12.1 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein T2SSE PF00437.20 EKX73728.1 - 0.055 12.5 0.0 0.11 11.5 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_19 PF13245.6 EKX73728.1 - 0.093 13.1 0.0 2.4 8.5 0.0 2.7 1 1 1 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EKX73728.1 - 0.13 12.0 0.0 0.33 10.7 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain ANAPC1 PF12859.7 EKX73728.1 - 0.15 12.6 0.0 0.66 10.5 0.0 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 1 AAA_23 PF13476.6 EKX73728.1 - 0.56 10.7 0.0 0.56 10.7 0.0 3.4 4 0 0 4 4 3 0 AAA domain zf-RING_11 PF17123.5 EKX73729.1 - 9e-11 41.3 1.2 2.1e-09 36.9 2.0 2.7 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_2 PF13639.6 EKX73729.1 - 2.4e-10 40.6 3.8 2.4e-10 40.6 3.8 2.1 3 0 0 3 3 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EKX73729.1 - 1.4e-09 37.6 3.8 4.4e-09 36.0 3.8 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EKX73729.1 - 4.7e-07 30.0 6.7 1.5e-06 28.4 5.0 2.6 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EKX73729.1 - 2.1e-06 27.5 2.3 2.1e-06 27.5 2.3 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EKX73729.1 - 1.4e-05 24.9 1.9 1.4e-05 24.9 1.9 2.2 3 0 0 3 3 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EKX73729.1 - 5.7e-05 23.1 3.4 0.00016 21.6 0.2 2.8 2 1 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EKX73729.1 - 0.12 12.3 5.4 0.46 10.4 5.4 2.0 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EKX73729.1 - 0.15 12.2 5.4 0.94 9.7 1.8 2.9 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-C3H2C3 PF17122.5 EKX73729.1 - 0.34 11.0 4.5 1.1 9.3 4.5 2.0 1 1 0 1 1 1 0 Zinc-finger zf-ANAPC11 PF12861.7 EKX73729.1 - 0.44 10.6 8.3 0.48 10.5 5.0 2.6 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 EKX73729.1 - 0.59 10.3 6.5 3.9 7.7 5.9 2.7 2 1 0 2 2 2 0 FANCL C-terminal domain Lig_chan PF00060.26 EKX73729.1 - 1.5 8.7 6.9 2.3 8.1 1.9 2.2 2 0 0 2 2 2 0 Ligand-gated ion channel zf-C3HC4_3 PF13920.6 EKX73729.1 - 2.7 7.9 10.0 0.41 10.5 5.4 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-P11 PF03854.14 EKX73729.1 - 4.1 7.1 11.4 30 4.4 6.6 3.0 2 1 0 2 2 2 0 P-11 zinc finger Zn_ribbon_17 PF17120.5 EKX73729.1 - 9.2 6.0 8.4 6.7 6.4 5.3 2.4 2 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type Ion_trans PF00520.31 EKX73730.1 - 0.0069 15.7 6.5 0.009 15.3 6.5 1.2 1 0 0 1 1 1 1 Ion transport protein PTPA PF03095.15 EKX73731.1 - 2.1e-73 247.4 0.0 2.8e-73 247.0 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Pro_sub2 PF18513.1 EKX73731.1 - 0.064 13.4 1.0 0.2 11.8 0.3 2.1 2 0 0 2 2 2 0 Prodomain subtilisin 2 His_Phos_2 PF00328.22 EKX73732.1 - 4e-54 184.4 0.0 3.8e-53 181.2 0.0 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 EKX73732.1 - 2e-34 117.6 0.1 7.8e-34 115.7 0.1 2.1 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 EKX73732.1 - 0.00015 21.4 0.0 0.00055 19.6 0.0 1.9 2 0 0 2 2 2 1 RimK-like ATP-grasp domain Asp PF00026.23 EKX73733.1 - 2.6e-52 178.2 1.6 2.6e-52 178.2 1.6 1.4 2 0 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EKX73733.1 - 1.3e-11 45.1 0.1 1.5e-09 38.4 0.1 2.7 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal VPS28 PF03997.12 EKX73734.1 - 2e-46 158.1 0.1 2.3e-46 157.9 0.1 1.0 1 0 0 1 1 1 1 VPS28 protein FAST_1 PF06743.15 EKX73736.1 - 0.00016 21.5 3.9 0.34 10.9 0.0 5.3 4 1 1 5 5 5 3 FAST kinase-like protein, subdomain 1 Adaptin_N PF01602.20 EKX73737.1 - 5.3e-50 170.5 20.0 5.3e-50 170.5 20.0 2.1 2 0 0 2 2 2 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 EKX73737.1 - 1e-28 99.9 0.0 7.7e-28 97.0 0.0 2.5 1 1 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 EKX73737.1 - 4.8e-14 52.5 1.6 2.2e-13 50.3 1.6 2.0 1 1 0 1 1 1 1 Coatomer beta C-terminal region RTP1_C1 PF10363.9 EKX73737.1 - 8.4e-05 22.7 2.5 0.0055 16.9 0.0 3.5 3 0 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT PF02985.22 EKX73737.1 - 0.00026 21.0 0.5 2.4 8.7 0.0 4.7 3 0 0 3 3 3 1 HEAT repeat Cnd1 PF12717.7 EKX73737.1 - 0.0018 18.4 0.0 0.0018 18.4 0.0 4.3 4 1 1 6 6 6 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EKX73737.1 - 0.0061 16.9 0.0 0.19 12.2 0.0 3.0 2 0 0 2 2 2 1 HEAT repeats Ribosomal_L27A PF00828.19 EKX73739.1 - 5.2e-16 59.5 0.1 1e-15 58.5 0.1 1.5 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Diphthamide_syn PF01866.17 EKX73740.1 - 1e-39 136.8 2.0 1.4e-39 136.3 2.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein CPW_WPC PF09717.10 EKX73741.1 - 5.6e-29 100.9 27.2 1.5e-14 54.7 2.0 3.1 3 0 0 3 3 3 3 Plasmodium falciparum domain of unknown function (CPW_WPC) COX2 PF00116.20 EKX73742.1 - 8.1e-44 148.4 0.0 1e-43 148.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, periplasmic domain Ribosomal_L17 PF01196.19 EKX73743.1 - 2.8e-18 66.6 0.0 5.9e-18 65.6 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L17 MMR_HSR1 PF01926.23 EKX73744.1 - 1.1e-15 57.7 0.1 1.4e-14 54.2 0.0 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EKX73744.1 - 1.6e-06 27.7 0.1 6.4e-06 25.8 0.1 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EKX73744.1 - 2.9e-05 24.0 0.0 0.029 14.3 0.0 3.0 3 0 0 3 3 3 2 RsgA GTPase Roc PF08477.13 EKX73744.1 - 0.074 13.3 0.5 3.3 8.0 0.0 3.3 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase Astro_capsid_p PF12226.8 EKX73744.1 - 1.2 8.2 16.6 2.2 7.3 16.6 1.4 1 0 0 1 1 1 0 Turkey astrovirus capsid protein NOA36 PF06524.12 EKX73744.1 - 5.1 6.3 14.8 11 5.3 14.8 1.6 1 0 0 1 1 1 0 NOA36 protein Pectate_lyase_2 PF06917.12 EKX73745.1 - 0.14 10.7 0.0 0.2 10.2 0.0 1.1 1 0 0 1 1 1 0 Periplasmic pectate lyase Pkinase PF00069.25 EKX73746.1 - 1.2e-67 228.1 0.7 1.4e-67 227.9 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKX73746.1 - 3.1e-31 108.6 0.2 5.4e-31 107.8 0.2 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EKX73746.1 - 7e-07 28.5 1.6 8.5e-07 28.2 0.4 1.7 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 EKX73746.1 - 6.9e-06 25.6 0.0 7.6e-05 22.2 0.0 2.3 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 EKX73746.1 - 0.0019 17.6 0.5 0.0032 16.9 0.5 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EKX73746.1 - 0.048 12.4 0.0 0.091 11.5 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase DUF1151 PF06625.11 EKX73746.1 - 0.18 11.8 0.1 0.34 10.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1151) ATP-grasp_2 PF08442.10 EKX73747.1 - 1.3e-59 201.2 0.1 1.9e-59 200.6 0.1 1.2 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 EKX73747.1 - 7.2e-19 68.1 0.0 1.6e-18 67.0 0.0 1.6 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 EKX73747.1 - 0.00055 19.8 0.0 0.00095 19.0 0.0 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain ATP-grasp_5 PF13549.6 EKX73747.1 - 0.0081 15.6 0.2 0.036 13.5 0.2 1.9 1 1 0 1 1 1 1 ATP-grasp domain TFIID_20kDa PF03847.13 EKX73747.1 - 0.13 12.8 0.4 0.45 11.1 0.4 1.9 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A SF-assemblin PF06705.11 EKX73748.1 - 2.8e-16 59.6 27.7 3.4e-16 59.3 27.7 1.0 1 0 0 1 1 1 1 SF-assemblin/beta giardin Apolipoprotein PF01442.18 EKX73748.1 - 0.036 13.9 16.2 3.1 7.6 0.6 2.4 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain DUF5402 PF17393.2 EKX73748.1 - 0.089 12.7 2.9 7.7 6.5 0.3 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5402) Mating_N PF12731.7 EKX73748.1 - 0.14 12.3 5.0 0.42 10.7 0.3 3.0 2 1 1 3 3 3 0 Mating-type protein beta 1 YtxH PF12732.7 EKX73748.1 - 0.38 11.3 8.9 8.7 7.0 0.7 3.5 2 1 1 3 3 3 0 YtxH-like protein GvpL_GvpF PF06386.11 EKX73748.1 - 1.2 9.0 5.6 1.5 8.7 3.5 2.0 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF Exonuc_VII_L PF02601.15 EKX73748.1 - 1.5 8.3 21.8 3.4 7.2 2.6 2.1 1 1 1 2 2 2 0 Exonuclease VII, large subunit V-ATPase_G PF03179.15 EKX73748.1 - 2.3 8.8 15.7 2.4 8.7 6.0 2.5 2 0 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit Baculo_PEP_C PF04513.12 EKX73748.1 - 2.9 7.9 21.8 11 6.1 10.7 3.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus PRESAN PF09687.10 EKX73748.1 - 4.1 8.0 16.4 6.7 7.3 3.5 3.1 1 1 1 2 2 2 0 Plasmodium RESA N-terminal Ribosomal_L14e PF01929.17 EKX73749.1 - 2.4e-22 79.2 2.8 3.2e-22 78.8 2.8 1.2 1 0 0 1 1 1 1 Ribosomal protein L14 DUF773 PF05600.12 EKX73750.1 - 1.6e-28 99.8 20.3 6.6e-18 64.7 5.1 2.0 1 1 1 2 2 2 2 CDK5 regulatory subunit-associated protein 3 TPR_MLP1_2 PF07926.12 EKX73750.1 - 0.41 10.7 8.3 1 9.4 1.3 2.9 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein FlaC_arch PF05377.11 EKX73750.1 - 0.72 10.3 13.9 0.4 11.1 0.8 4.5 5 0 0 5 5 5 0 Flagella accessory protein C (FlaC) LemA PF04011.12 EKX73750.1 - 4.4 7.2 8.0 1.8 8.4 0.7 2.7 2 1 0 2 2 2 0 LemA family KLRAQ PF10205.9 EKX73750.1 - 9.6 6.5 10.1 10 6.4 1.1 2.9 3 1 0 3 3 3 0 Predicted coiled-coil domain-containing protein Syntaxin PF00804.25 EKX73751.1 - 4.9e-07 29.6 4.6 0.0074 16.0 1.4 2.3 1 1 1 2 2 2 2 Syntaxin TACC_C PF05010.14 EKX73751.1 - 0.0033 17.3 6.4 0.0084 15.9 2.2 2.2 1 1 1 2 2 2 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal YscO-like PF16789.5 EKX73751.1 - 0.013 15.5 3.5 0.014 15.4 1.7 1.9 1 1 1 2 2 2 0 YscO-like protein EzrA PF06160.12 EKX73751.1 - 0.017 13.3 13.3 0.0057 14.9 3.9 2.4 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA BLOC1_2 PF10046.9 EKX73751.1 - 0.021 15.1 10.5 1.5 9.1 4.9 3.3 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 EF-G-binding_N PF07299.11 EKX73751.1 - 0.023 15.2 4.0 0.084 13.4 2.2 2.5 2 0 0 2 2 2 0 Elongation factor G-binding protein, N-terminal Syntaxin_2 PF14523.6 EKX73751.1 - 0.026 14.9 11.8 0.067 13.6 2.1 3.0 1 1 1 2 2 2 0 Syntaxin-like protein HTH_47 PF16221.5 EKX73751.1 - 0.042 13.4 0.0 0.12 12.0 0.0 1.8 1 0 0 1 1 1 0 winged helix-turn-helix DHR10 PF18595.1 EKX73751.1 - 0.048 13.7 6.4 0.98 9.5 4.5 2.5 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain RSS_P20 PF11757.8 EKX73751.1 - 0.051 14.0 0.6 0.051 14.0 0.6 2.6 2 2 0 2 2 2 0 Suppressor of RNA silencing P21-like N-terminal domain NOG1_N PF17835.1 EKX73751.1 - 0.052 13.5 3.2 0.11 12.4 0.7 2.2 2 0 0 2 2 2 0 NOG1 N-terminal helical domain DASH_Spc34 PF08657.10 EKX73751.1 - 0.064 13.0 9.4 1.5 8.5 4.7 2.6 1 1 1 2 2 2 0 DASH complex subunit Spc34 DUF948 PF06103.11 EKX73751.1 - 0.087 13.1 2.2 1.9 8.8 1.4 2.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) THOC7 PF05615.13 EKX73751.1 - 0.13 12.5 7.6 0.21 11.9 6.0 2.2 1 1 1 2 2 2 0 Tho complex subunit 7 DUF16 PF01519.16 EKX73751.1 - 0.38 11.3 7.2 2.9 8.4 0.7 2.9 1 1 1 2 2 2 0 Protein of unknown function DUF16 Efg1 PF10153.9 EKX73751.1 - 0.54 10.6 4.7 3.2 8.2 0.1 2.4 1 1 1 2 2 2 0 rRNA-processing protein Efg1 UPF0242 PF06785.11 EKX73751.1 - 0.79 9.8 9.1 1.8 8.7 4.1 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF3450 PF11932.8 EKX73751.1 - 0.8 9.0 6.2 5.8 6.2 3.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) ISG65-75 PF11727.8 EKX73751.1 - 0.94 8.6 6.3 0.24 10.6 2.9 1.7 2 1 0 2 2 2 0 Invariant surface glycoprotein DUF4460 PF14687.6 EKX73751.1 - 1.6 8.8 7.1 0.27 11.3 0.6 2.7 2 1 2 4 4 3 0 Domain of unknown function (DUF4460) BRE1 PF08647.11 EKX73751.1 - 1.9 8.6 9.4 0.49 10.5 4.7 2.4 2 2 0 2 2 2 0 BRE1 E3 ubiquitin ligase Seryl_tRNA_N PF02403.22 EKX73751.1 - 5.2 7.4 9.1 2.5 8.4 3.5 2.8 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Fib_alpha PF08702.10 EKX73751.1 - 6.3 7.0 12.7 3 8.0 6.6 2.7 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family MCU PF04678.13 EKX73751.1 - 9.3 6.3 6.8 8 6.5 1.8 2.8 1 1 1 3 3 3 0 Mitochondrial calcium uniporter Nop10p PF04135.12 EKX73752.1 - 5.1e-21 74.5 0.9 5.7e-21 74.3 0.9 1.0 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family Rtf2 PF04641.12 EKX73753.1 - 2.5e-46 158.2 0.0 4.2e-46 157.4 0.0 1.3 1 1 0 1 1 1 1 Rtf2 RING-finger zf-NOSIP PF15906.5 EKX73753.1 - 0.0031 17.6 0.0 0.0068 16.5 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein TF_Zn_Ribbon PF08271.12 EKX73753.1 - 0.063 12.8 1.3 0.24 10.9 1.1 2.0 2 0 0 2 2 2 0 TFIIB zinc-binding zf-Nse PF11789.8 EKX73753.1 - 0.9 9.4 5.1 1.8 8.4 0.4 2.2 1 1 1 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit RAP PF08373.10 EKX73754.1 - 0.0006 19.9 0.1 0.0018 18.3 0.1 1.9 1 0 0 1 1 1 1 RAP domain Spy1 PF11357.8 EKX73754.1 - 0.32 11.3 2.3 2.5 8.4 0.0 3.0 3 1 1 4 4 4 0 Cell cycle regulatory protein Rrp15p PF07890.12 EKX73756.1 - 0.013 15.9 4.9 0.021 15.1 4.9 1.3 1 1 0 1 1 1 0 Rrp15p DUF3452 PF11934.8 EKX73756.1 - 0.03 13.9 2.3 0.033 13.7 2.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3452) Toxin_10 PF05431.11 EKX73756.1 - 0.13 11.7 2.1 0.15 11.5 2.1 1.2 1 0 0 1 1 1 0 Insecticidal Crystal Toxin, P42 DUF5526 PF17664.1 EKX73756.1 - 0.25 10.9 6.2 0.86 9.1 0.3 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5526) Hydrolase_4 PF12146.8 EKX73757.1 - 2e-23 82.9 0.0 5.3e-21 75.0 0.0 2.9 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EKX73757.1 - 0.0019 18.9 0.0 0.0038 17.9 0.0 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EKX73757.1 - 0.0023 17.4 0.0 0.0061 16.1 0.0 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 EKX73757.1 - 0.0034 17.2 0.0 0.24 11.1 0.0 2.9 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 EKX73757.1 - 0.025 14.2 1.1 1.7 8.2 0.0 2.7 3 1 0 3 3 3 0 alpha/beta hydrolase fold zf-HC5HC2H_2 PF13832.6 EKX73758.1 - 4.3e-16 59.0 38.1 2.1e-14 53.6 5.1 4.5 3 2 1 4 4 4 2 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EKX73758.1 - 1.8e-09 37.7 15.3 2.5e-06 27.6 2.9 5.4 4 1 1 5 5 5 2 PHD-like zinc-binding domain DUF5537 PF17690.1 EKX73758.1 - 0.054 13.2 0.1 0.19 11.4 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5537) zf-RING-like PF08746.11 EKX73758.1 - 7.7 6.9 30.1 0.2 12.0 2.4 4.5 4 0 0 4 4 4 0 RING-like domain Sybindin PF04099.12 EKX73759.1 - 7.4e-18 64.8 0.5 9.3e-18 64.5 0.5 1.3 1 1 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EKX73759.1 - 4.6e-06 26.8 0.0 6.6e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region MutS_V PF00488.21 EKX73760.1 - 1.4e-14 54.5 0.1 2.9e-14 53.5 0.1 1.5 1 0 0 1 1 1 1 MutS domain V MutS_I PF01624.20 EKX73760.1 - 1.8e-08 34.6 0.0 4.6e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 MutS domain I AAA_14 PF13173.6 EKX73760.1 - 0.034 14.2 0.3 0.34 11.0 0.0 2.9 2 1 0 2 2 2 0 AAA domain DUF4434 PF14488.6 EKX73760.1 - 0.039 14.0 0.2 0.89 9.5 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4434) Ribonuc_red_sm PF00268.21 EKX73761.1 - 2.2e-112 375.1 0.5 2.6e-112 374.8 0.5 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain NMT PF01233.19 EKX73761.1 - 0.0048 16.7 0.1 0.0085 15.9 0.1 1.3 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain DUF4744 PF15918.5 EKX73761.1 - 0.2 12.5 0.0 0.39 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4744) EF1G PF00647.19 EKX73761.1 - 0.4 10.8 2.4 2.3 8.3 0.1 2.3 2 0 0 2 2 2 0 Elongation factor 1 gamma, conserved domain GTP_EFTU PF00009.27 EKX73762.1 - 2.4e-52 177.3 0.0 3.3e-52 176.9 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EKX73762.1 - 2.1e-39 134.3 1.7 3.9e-39 133.4 0.4 2.0 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EKX73762.1 - 3.9e-13 49.6 0.3 1.4e-12 47.8 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EKX73762.1 - 0.00015 21.8 0.2 0.0084 16.2 0.1 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase Semialdhyde_dhC PF02774.18 EKX73762.1 - 0.068 13.2 0.7 0.12 12.4 0.3 1.7 1 1 1 2 2 2 0 Semialdehyde dehydrogenase, dimerisation domain GTP_EFTU PF00009.27 EKX73763.1 - 2.4e-52 177.3 0.0 3.3e-52 176.9 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EKX73763.1 - 2.1e-39 134.3 1.7 3.9e-39 133.4 0.4 2.0 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EKX73763.1 - 3.9e-13 49.6 0.3 1.4e-12 47.8 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EKX73763.1 - 0.00015 21.8 0.2 0.0084 16.2 0.1 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase Semialdhyde_dhC PF02774.18 EKX73763.1 - 0.068 13.2 0.7 0.12 12.4 0.3 1.7 1 1 1 2 2 2 0 Semialdehyde dehydrogenase, dimerisation domain tRNA-synt_1c PF00749.21 EKX73764.1 - 4.1e-71 239.4 0.6 2.1e-69 233.8 0.6 2.4 1 1 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain DUF2935 PF11155.8 EKX73764.1 - 0.0047 17.3 1.9 0.011 16.1 1.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF2935) RE_EcoO109I PF14511.6 EKX73764.1 - 0.013 15.1 0.1 0.12 11.9 0.1 2.3 2 0 0 2 2 2 0 Type II restriction endonuclease EcoO109I Ku_PK_bind PF08785.11 EKX73764.1 - 0.11 12.6 0.5 6.1 7.0 0.1 2.6 2 0 0 2 2 2 0 Ku C terminal domain like Pkinase PF00069.25 EKX73765.1 - 4.3e-76 255.8 0.0 4.9e-76 255.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKX73765.1 - 4.6e-33 114.6 0.0 5.7e-33 114.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKX73765.1 - 0.00096 18.5 0.0 0.0022 17.4 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EKX73765.1 - 0.0047 15.9 0.0 0.015 14.3 0.0 1.8 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EKX73765.1 - 0.0049 16.8 0.2 0.013 15.4 0.1 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EKX73765.1 - 0.02 14.3 0.1 0.066 12.6 0.1 1.8 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EKX73765.1 - 0.026 14.1 0.0 4.3 6.9 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EKX73765.1 - 0.079 12.6 0.0 0.28 10.8 0.0 1.8 1 1 0 1 1 1 0 RIO1 family DUF166 PF02593.14 EKX73766.1 - 0.0057 16.2 0.1 0.0074 15.9 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function Cmc1 PF08583.10 EKX73766.1 - 0.01 15.8 1.9 0.015 15.3 1.9 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like GCK PF07802.11 EKX73766.1 - 0.066 13.6 2.3 6.5 7.2 0.1 2.7 1 1 1 3 3 3 0 GCK domain DnaJ PF00226.31 EKX73767.1 - 3.2e-22 78.4 3.3 7.4e-22 77.3 3.3 1.6 1 0 0 1 1 1 1 DnaJ domain RCC1 PF00415.18 EKX73768.1 - 4.2e-37 126.6 15.5 5e-14 52.6 0.3 7.3 6 1 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EKX73768.1 - 5.6e-27 92.9 17.1 5e-10 38.9 0.1 6.8 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat WD40 PF00400.32 EKX73768.1 - 1.8 9.6 7.6 47 5.1 0.1 4.8 5 0 0 5 5 5 0 WD domain, G-beta repeat Pkinase PF00069.25 EKX73769.1 - 1.4e-16 60.6 0.0 1.8e-08 34.1 0.0 3.9 3 1 0 3 3 3 2 Protein kinase domain UQ_con PF00179.26 EKX73770.1 - 7.6e-48 161.7 0.0 1.3e-47 161.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EKX73770.1 - 5.6e-05 22.9 0.0 7.6e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UBA_4 PF14555.6 EKX73770.1 - 0.00062 19.5 0.0 0.001 18.9 0.0 1.3 1 0 0 1 1 1 1 UBA-like domain RWD PF05773.22 EKX73770.1 - 0.0014 18.9 0.0 0.0021 18.4 0.0 1.4 1 0 0 1 1 1 1 RWD domain UBA PF00627.31 EKX73770.1 - 0.0043 16.9 0.0 0.0079 16.1 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain TAP_C PF03943.13 EKX73770.1 - 0.069 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 TAP C-terminal domain UEV PF05743.13 EKX73770.1 - 0.079 12.8 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 UEV domain Tim17 PF02466.19 EKX73771.1 - 4.3e-17 62.5 5.9 5.8e-17 62.1 5.9 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family UEV PF05743.13 EKX73772.1 - 9.8e-25 86.8 0.3 9.8e-25 86.8 0.3 2.1 3 0 0 3 3 3 1 UEV domain Vps23_core PF09454.10 EKX73772.1 - 1e-05 25.4 0.4 2.3e-05 24.2 0.3 1.7 1 1 0 1 1 1 1 Vps23 core domain UQ_con PF00179.26 EKX73772.1 - 0.0001 22.0 0.4 0.00022 20.9 0.4 1.6 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme DUF1664 PF07889.12 EKX73772.1 - 0.19 11.8 1.4 0.4 10.7 1.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) MutS_III PF05192.18 EKX73772.1 - 0.47 10.6 5.3 0.65 10.2 4.2 1.8 1 1 0 1 1 1 0 MutS domain III Glutaredoxin PF00462.24 EKX73773.1 - 6.7e-16 58.3 0.1 1.4e-15 57.2 0.1 1.6 1 0 0 1 1 1 1 Glutaredoxin Cauli_DNA-bind PF03310.13 EKX73773.1 - 0.55 10.3 4.1 0.45 10.6 2.2 1.8 1 1 1 2 2 2 0 Caulimovirus DNA-binding protein DUF3552 PF12072.8 EKX73774.1 - 5.7e-05 22.6 51.1 0.00036 20.0 19.2 5.7 2 1 4 6 6 6 3 Domain of unknown function (DUF3552) DUF3450 PF11932.8 EKX73774.1 - 0.0058 16.0 16.2 0.0058 16.0 16.2 4.3 2 1 2 5 5 5 2 Protein of unknown function (DUF3450) Flagellin_C PF00700.21 EKX73774.1 - 0.0067 16.8 22.9 0.93 9.9 0.4 5.0 1 1 1 4 4 4 2 Bacterial flagellin C-terminal helical region Sec34 PF04136.15 EKX73774.1 - 0.69 9.8 50.7 0.57 10.1 9.1 4.7 1 1 3 4 4 4 0 Sec34-like family Mce4_CUP1 PF11887.8 EKX73774.1 - 1.7 8.1 16.0 5.3 6.4 8.3 2.7 1 1 1 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative NPV_P10 PF05531.12 EKX73774.1 - 2.1 8.9 43.0 1.1 9.7 3.7 4.8 1 1 4 5 5 5 0 Nucleopolyhedrovirus P10 protein Exonuc_VII_L PF02601.15 EKX73774.1 - 2.2 7.8 57.6 1.2 8.6 18.7 3.4 1 1 1 2 2 2 0 Exonuclease VII, large subunit Sas10 PF09368.10 EKX73776.1 - 1.9e-19 69.9 7.8 1.9e-19 69.9 7.8 3.5 3 1 0 3 3 3 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 EKX73776.1 - 1.6e-13 51.0 5.6 2.9e-13 50.2 3.1 2.9 1 1 1 2 2 2 1 Sas10/Utp3/C1D family Filamin PF00630.19 EKX73777.1 - 5.3e-11 43.2 0.6 5.5e-10 40.0 0.0 2.8 3 0 0 3 3 3 1 Filamin/ABP280 repeat DUF5082 PF16888.5 EKX73777.1 - 0.016 15.5 1.4 0.07 13.4 1.4 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) DUF16 PF01519.16 EKX73777.1 - 2.9 8.4 8.0 1.7 9.2 4.3 2.6 2 1 0 2 2 2 0 Protein of unknown function DUF16 PKK PF12474.8 EKX73780.1 - 0.05 13.7 2.7 0.078 13.1 2.7 1.2 1 0 0 1 1 1 0 Polo kinase kinase Ank_2 PF12796.7 EKX73782.1 - 3e-17 63.0 0.0 5.8e-17 62.1 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EKX73782.1 - 8.8e-16 57.6 1.0 2.6e-08 34.0 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeat ACBP PF00887.19 EKX73782.1 - 4.7e-15 55.6 0.0 1.2e-14 54.3 0.0 1.6 2 0 0 2 2 2 1 Acyl CoA binding protein Ank_5 PF13857.6 EKX73782.1 - 5.5e-14 52.1 1.2 1.7e-11 44.1 0.2 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EKX73782.1 - 8.8e-14 51.7 0.0 1.4e-07 31.9 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EKX73782.1 - 3.5e-12 45.4 0.1 2.4e-06 27.4 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat SET PF00856.28 EKX73783.1 - 1.1e-10 42.1 0.0 3.3e-10 40.6 0.0 1.8 2 0 0 2 2 2 1 SET domain Nop PF01798.18 EKX73784.1 - 8.6e-80 267.5 0.5 8.6e-80 267.5 0.5 1.7 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EKX73784.1 - 2.2e-17 63.2 0.1 2.2e-17 63.2 0.1 3.1 4 0 0 4 4 4 1 NOP5NT (NUC127) domain GAGA_bind PF06217.12 EKX73784.1 - 2.4 8.4 12.8 3.9 7.7 12.8 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family MOZ_SAS PF01853.18 EKX73786.1 - 2.5e-70 235.8 0.3 3.8e-70 235.2 0.3 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EKX73786.1 - 9.5e-22 76.4 1.5 2.3e-21 75.1 1.5 1.7 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 EKX73786.1 - 1.7e-11 43.8 0.3 4.1e-11 42.6 0.3 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Peptidase_M16_C PF05193.21 EKX73787.1 - 8.4e-16 58.5 0.0 2.5e-08 34.1 0.0 4.3 3 1 0 3 3 3 3 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EKX73787.1 - 4.7e-09 36.4 0.2 1.1e-07 31.9 0.0 2.6 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) HSP90 PF00183.18 EKX73788.1 - 4.2e-109 365.8 9.9 3.5e-107 359.5 7.5 2.1 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.6 EKX73788.1 - 3.9e-11 42.9 0.1 8.8e-11 41.8 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EKX73788.1 - 2.7e-07 31.1 0.0 6.3e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Hen1_L PF12623.7 EKX73788.1 - 0.15 11.1 0.0 0.24 10.4 0.0 1.2 1 0 0 1 1 1 0 RNA repair, ligase-Pnkp-associating, region of Hen1 Clat_adaptor_s PF01217.20 EKX73789.1 - 6e-49 165.6 4.3 6.9e-49 165.4 4.3 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Aurora-A_bind PF09041.10 EKX73791.1 - 0.027 14.5 0.4 0.24 11.5 0.1 2.5 2 0 0 2 2 2 0 Aurora-A binding Mlh1_C PF16413.5 EKX73792.1 - 8.7e-28 97.4 0.0 1.7e-27 96.4 0.0 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 EKX73792.1 - 1.1e-18 67.0 0.4 2.6e-18 65.8 0.4 1.7 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EKX73792.1 - 1.7e-11 44.1 0.0 3.5e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EKX73792.1 - 2.7e-05 24.6 0.0 5.8e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase IQ_SEC7_PH PF16453.5 EKX73792.1 - 0.0087 16.0 0.0 0.66 9.9 0.0 2.4 2 0 0 2 2 2 1 PH domain Ras PF00071.22 EKX73793.1 - 3.7e-48 163.2 0.0 4.5e-48 162.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKX73793.1 - 1.6e-30 105.8 0.0 2.8e-30 105.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKX73793.1 - 3.4e-12 46.2 0.0 4.4e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKX73793.1 - 1e-05 25.6 0.0 1.5e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 EKX73793.1 - 0.002 18.5 0.0 0.0087 16.4 0.0 1.9 1 1 0 1 1 1 1 RNA helicase RsgA_GTPase PF03193.16 EKX73793.1 - 0.0054 16.7 0.0 0.4 10.6 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 EKX73793.1 - 0.008 16.6 0.0 0.011 16.1 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain G-alpha PF00503.20 EKX73793.1 - 0.0094 15.1 0.2 1.2 8.2 0.1 2.8 2 1 1 3 3 3 1 G-protein alpha subunit Gtr1_RagA PF04670.12 EKX73793.1 - 0.0095 15.3 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_7 PF12775.7 EKX73793.1 - 0.013 15.0 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region ArgoMid PF16487.5 EKX73793.1 - 0.014 15.6 0.0 0.024 14.9 0.0 1.4 1 0 0 1 1 1 0 Mid domain of argonaute NB-ARC PF00931.22 EKX73793.1 - 0.043 13.0 0.1 0.067 12.4 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain ABC_tran PF00005.27 EKX73793.1 - 0.074 13.6 0.1 1.1 9.8 0.0 2.3 2 1 0 2 2 2 0 ABC transporter Septin PF00735.18 EKX73793.1 - 0.1 11.8 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 Septin TniB PF05621.11 EKX73793.1 - 0.1 12.0 0.0 0.4 10.0 0.0 1.8 2 0 0 2 2 2 0 Bacterial TniB protein TsaE PF02367.17 EKX73793.1 - 0.16 12.0 0.1 0.29 11.1 0.1 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 EKX73793.1 - 0.17 11.9 0.2 0.44 10.6 0.2 1.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EKX73793.1 - 0.17 12.1 0.1 0.58 10.4 0.1 1.8 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EKX73793.1 - 0.2 11.6 0.2 0.52 10.2 0.1 1.7 2 0 0 2 2 2 0 NACHT domain efThoc1 PF11957.8 EKX73794.1 - 2e-10 39.9 1.1 5e-08 32.1 0.9 2.4 1 1 0 1 1 1 1 THO complex subunit 1 transcription elongation factor tRNA-synt_1b PF00579.25 EKX73796.1 - 1.8e-36 125.9 0.7 9e-36 123.7 0.7 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) ThiS-like PF14453.6 EKX73796.1 - 0.42 10.7 2.9 9.3 6.4 0.2 3.2 3 0 0 3 3 3 0 ThiS-like ubiquitin DUF3273 PF11677.8 EKX73797.1 - 9.8e-97 323.4 16.5 1.2e-96 323.1 16.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) Carbpep_Y_N PF05388.11 EKX73798.1 - 0.042 14.4 0.0 0.14 12.7 0.0 2.0 1 0 0 1 1 1 0 Carboxypeptidase Y pro-peptide Clat_adaptor_s PF01217.20 EKX73799.1 - 6e-43 146.2 5.1 6.7e-43 146.0 5.1 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain HOCHOB PF17943.1 EKX73799.1 - 0.1 13.3 1.3 0.19 12.5 0.2 1.9 1 1 0 2 2 2 0 Homeobox-cysteine loop-homeobox MRG PF05712.13 EKX73799.1 - 0.11 11.7 0.2 0.12 11.7 0.2 1.2 1 0 0 1 1 1 0 MRG FAINT PF04385.15 EKX73800.1 - 1.1e-16 60.6 13.3 7.4e-05 22.7 2.0 4.5 4 0 0 4 4 4 4 Domain of unknown function, DUF529 PAS_10 PF13596.6 EKX73800.1 - 0.0054 17.3 0.1 1.4 9.6 0.0 2.8 3 0 0 3 3 3 1 PAS domain PBC PF03792.13 EKX73800.1 - 0.079 12.7 0.5 0.32 10.7 0.2 2.1 2 0 0 2 2 2 0 PBC domain Defensin_5 PF18251.1 EKX73800.1 - 0.23 11.6 2.6 8.3 6.6 0.1 2.5 2 0 0 2 2 2 0 Fungal defensin Copsin FAINT PF04385.15 EKX73801.1 - 3.3e-11 43.1 1.9 0.0011 19.0 0.9 3.3 3 0 0 3 3 3 3 Domain of unknown function, DUF529 MscL PF01741.18 EKX73802.1 - 0.2 11.9 1.4 0.54 10.6 1.4 1.7 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL DEAD PF00270.29 EKX73803.1 - 1.6e-44 151.8 0.7 3.7e-44 150.6 0.2 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKX73803.1 - 4.5e-33 113.9 0.3 1.5e-31 109.0 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKX73803.1 - 3.6e-06 27.1 0.1 1.1e-05 25.6 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EKX73803.1 - 0.0016 18.2 0.0 0.0026 17.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EKX73803.1 - 0.01 16.2 0.1 0.029 14.7 0.1 1.8 1 1 0 1 1 1 0 AAA domain CMS1 PF14617.6 EKX73803.1 - 0.03 13.7 0.0 0.069 12.5 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit PhoH PF02562.16 EKX73803.1 - 0.064 12.7 0.0 0.18 11.2 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein DUF2075 PF09848.9 EKX73803.1 - 0.069 12.4 0.2 0.25 10.5 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.14 EKX73803.1 - 0.15 11.9 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 Helicase TilS_C PF11734.8 EKX73804.1 - 0.066 12.7 0.0 0.76 9.2 0.0 2.2 2 0 0 2 2 2 0 TilS substrate C-terminal domain DUF2981 PF11200.8 EKX73806.1 - 0.97 9.1 2.3 1.2 8.8 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) DUF1075 PF06388.11 EKX73806.1 - 6.2 6.9 8.0 9.3 6.3 0.2 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1075) ABC_tran PF00005.27 EKX73807.1 - 5.7e-29 101.4 0.0 9.1e-15 55.4 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EKX73807.1 - 2.1e-05 24.5 3.4 0.092 12.5 0.1 3.6 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EKX73807.1 - 3e-05 23.7 1.2 0.2 11.4 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EKX73807.1 - 5.4e-05 23.6 0.0 0.053 13.9 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EKX73807.1 - 0.00047 20.1 0.9 0.13 12.1 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_18 PF13238.6 EKX73807.1 - 0.0006 20.4 0.1 2.3 8.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain DUF87 PF01935.17 EKX73807.1 - 0.0011 19.1 1.7 0.14 12.2 0.1 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain Dynamin_N PF00350.23 EKX73807.1 - 0.0017 18.5 0.1 0.29 11.2 0.0 2.3 2 0 0 2 2 2 1 Dynamin family AAA_30 PF13604.6 EKX73807.1 - 0.002 17.9 0.0 0.54 9.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 EKX73807.1 - 0.0026 16.8 0.5 0.024 13.6 0.0 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 EKX73807.1 - 0.0037 16.6 0.2 1.2 8.4 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin MMR_HSR1 PF01926.23 EKX73807.1 - 0.004 17.2 0.1 0.21 11.7 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase DnaB_C PF03796.15 EKX73807.1 - 0.0079 15.6 0.0 0.26 10.6 0.0 2.2 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain FtsK_SpoIIIE PF01580.18 EKX73807.1 - 0.0081 15.5 0.7 0.85 8.9 0.1 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_15 PF13175.6 EKX73807.1 - 0.0083 15.9 0.1 2.8 7.5 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EKX73807.1 - 0.0093 16.2 0.1 0.98 9.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 EKX73807.1 - 0.0094 15.4 0.6 0.11 11.9 0.0 2.5 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain Fer4_NifH PF00142.18 EKX73807.1 - 0.018 14.5 0.1 5.4 6.4 0.0 2.3 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family T2SSE PF00437.20 EKX73807.1 - 0.043 12.9 1.8 2.7 7.0 0.2 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein NACHT PF05729.12 EKX73807.1 - 0.053 13.4 0.3 11 5.9 0.1 2.6 2 0 0 2 2 2 0 NACHT domain AAA_23 PF13476.6 EKX73807.1 - 0.1 13.1 4.8 5.4 7.5 0.1 2.7 3 0 0 3 3 2 0 AAA domain ATP_bind_1 PF03029.17 EKX73807.1 - 0.1 12.3 0.1 14 5.3 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_25 PF13481.6 EKX73807.1 - 0.11 12.1 0.2 2.1 7.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 EKX73807.1 - 0.14 12.4 0.0 0.31 11.3 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit NB-ARC PF00931.22 EKX73807.1 - 0.16 11.1 0.9 0.93 8.6 0.1 2.2 2 0 0 2 2 2 0 NB-ARC domain F-box PF00646.33 EKX73809.1 - 0.15 12.0 2.1 0.23 11.4 0.5 2.2 2 0 0 2 2 2 0 F-box domain Imm61 PF15598.6 EKX73811.1 - 0.085 12.7 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Immunity protein 61 CAF1C_H4-bd PF12265.8 EKX73812.1 - 1.3e-18 67.0 0.0 3.2e-18 65.7 0.0 1.7 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EKX73812.1 - 2.8e-08 34.3 14.8 0.037 14.9 0.3 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKX73812.1 - 0.0024 18.1 0.1 0.28 11.5 0.0 3.6 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EKX73812.1 - 0.017 15.0 0.0 0.031 14.2 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A FAINT PF04385.15 EKX73814.1 - 5.7e-05 23.1 0.0 8.9e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function, DUF529 Myosin_head PF00063.21 EKX73815.1 - 5.5e-196 652.8 5.5 7.5e-196 652.3 5.5 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.27 EKX73815.1 - 5.5e-11 41.2 17.3 0.0011 18.5 0.0 4.8 4 0 0 4 4 4 3 IQ calmodulin-binding motif AAA_22 PF13401.6 EKX73815.1 - 1.6e-06 28.4 4.1 0.11 12.8 0.1 4.1 4 0 0 4 4 4 2 AAA domain WD40 PF00400.32 EKX73815.1 - 7.7e-06 26.6 2.6 0.31 12.0 0.1 5.7 7 0 0 7 7 4 1 WD domain, G-beta repeat AAA_16 PF13191.6 EKX73815.1 - 4.4e-05 23.9 0.8 0.25 11.7 0.0 2.9 3 0 0 3 3 2 2 AAA ATPase domain RNA_helicase PF00910.22 EKX73815.1 - 0.00097 19.5 0.1 3.8 7.9 0.0 3.5 2 0 0 2 2 2 2 RNA helicase Rad17 PF03215.15 EKX73815.1 - 0.0053 16.7 0.1 5.2 6.9 0.0 2.9 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_19 PF13245.6 EKX73815.1 - 0.012 16.0 0.0 3.6 7.9 0.0 3.1 2 1 0 2 2 2 0 AAA domain ANAPC4_WD40 PF12894.7 EKX73815.1 - 0.013 15.8 0.0 9.9 6.5 0.0 3.6 1 1 2 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain ABC_tran PF00005.27 EKX73815.1 - 0.025 15.1 0.9 5.6 7.5 0.0 3.1 3 0 0 3 3 2 0 ABC transporter AAA_18 PF13238.6 EKX73815.1 - 0.05 14.2 0.1 13 6.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain HALZ PF02183.18 EKX73815.1 - 0.051 13.8 1.0 0.13 12.5 1.0 1.7 1 0 0 1 1 1 0 Homeobox associated leucine zipper AAA_5 PF07728.14 EKX73815.1 - 0.056 13.4 0.3 1.8 8.6 0.0 3.0 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EKX73815.1 - 0.058 12.9 0.1 12 5.3 0.1 2.7 2 0 0 2 2 2 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 EKX73815.1 - 0.068 12.4 3.2 3.3 6.9 0.1 3.3 3 0 0 3 3 3 0 Zeta toxin RsgA_GTPase PF03193.16 EKX73815.1 - 0.099 12.5 0.0 24 4.8 0.0 2.7 2 0 0 2 2 2 0 RsgA GTPase DUF4047 PF13256.6 EKX73815.1 - 0.12 12.6 3.0 0.34 11.1 3.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4047) AAA_29 PF13555.6 EKX73815.1 - 0.13 12.0 0.2 7.3 6.4 0.1 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain TMF_TATA_bd PF12325.8 EKX73815.1 - 0.32 11.2 13.4 0.12 12.6 9.4 2.4 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding AAA_23 PF13476.6 EKX73815.1 - 1.4 9.3 8.2 29 5.1 0.0 3.7 3 0 0 3 3 3 0 AAA domain Myosin_N PF02736.19 EKX73816.1 - 0.027 14.3 1.0 0.035 13.9 0.9 1.4 1 1 0 1 1 1 0 Myosin N-terminal SH3-like domain PI-PLC-X PF00388.19 EKX73818.1 - 5.4e-41 139.6 0.0 1.3e-40 138.4 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EKX73818.1 - 6e-26 91.0 0.0 1.6e-25 89.7 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 EKX73818.1 - 3.2e-11 43.4 0.1 2.2e-10 40.7 0.0 2.3 2 0 0 2 2 2 1 C2 domain Mcp5_PH PF12814.7 EKX73818.1 - 0.00058 20.0 0.2 0.0012 19.0 0.2 1.5 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology FAINT PF04385.15 EKX73819.1 - 7.4e-06 25.9 3.1 0.00015 21.7 0.3 2.9 3 0 0 3 3 3 2 Domain of unknown function, DUF529 Glyco_hydro_79C PF16862.5 EKX73821.1 - 0.013 16.3 0.2 0.94 10.4 0.0 2.9 2 1 0 2 2 2 0 Glycosyl hydrolase family 79 C-terminal beta domain Pico_P2A PF00947.19 EKX73821.1 - 0.055 13.5 0.4 0.17 11.9 0.4 1.8 1 0 0 1 1 1 0 Picornavirus core protein 2A UnbV_ASPIC PF07593.12 EKX73821.1 - 0.071 13.1 0.2 0.24 11.4 0.1 1.9 2 0 0 2 2 2 0 ASPIC and UnbV TMEM192 PF14802.6 EKX73822.1 - 0.39 9.8 3.9 4.8 6.2 1.1 2.1 2 0 0 2 2 2 0 TMEM192 family Pur_ac_phosph_N PF16656.5 EKX73824.1 - 0.16 12.6 1.6 2.2 8.9 0.3 2.8 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain zf-RING_10 PF16685.5 EKX73824.1 - 0.56 10.4 2.3 1.6 9.0 2.3 1.8 1 0 0 1 1 1 0 zinc RING finger of MSL2 Utp14 PF04615.13 EKX73826.1 - 1e-55 189.7 59.9 7.9e-54 183.5 59.8 3.1 1 1 0 1 1 1 1 Utp14 protein Spem1 PF15670.5 EKX73826.1 - 5.4 6.5 12.5 0.07 12.7 2.6 2.7 3 0 0 3 3 3 0 Spermatid maturation protein 1 60KD_IMP PF02096.20 EKX73827.1 - 0.2 11.5 1.2 0.73 9.7 0.2 2.3 1 1 1 2 2 2 0 60Kd inner membrane protein FAINT PF04385.15 EKX73830.1 - 4e-07 30.0 7.2 0.00049 20.1 2.2 2.7 2 1 0 2 2 2 2 Domain of unknown function, DUF529 Thioredoxin_8 PF13905.6 EKX73830.1 - 0.22 11.9 1.2 0.46 10.9 0.2 2.0 2 0 0 2 2 2 0 Thioredoxin-like Pribosyltran PF00156.27 EKX73831.1 - 4.1e-18 65.4 0.0 5.2e-18 65.1 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EKX73831.1 - 0.012 15.1 0.0 0.019 14.4 0.0 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase BT1 PF03092.16 EKX73832.1 - 2.4e-38 131.7 5.3 2.9e-38 131.4 5.3 1.0 1 0 0 1 1 1 1 BT1 family MFS_1 PF07690.16 EKX73832.1 - 0.0022 17.0 0.0 0.0028 16.6 0.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EKX73832.1 - 1.4 7.7 8.6 0.28 10.0 1.8 2.3 2 1 1 3 3 3 0 MFS_1 like family FAINT PF04385.15 EKX73833.1 - 4.4e-42 142.0 22.7 1.9e-07 31.1 0.3 8.6 8 0 0 8 8 8 8 Domain of unknown function, DUF529 BT1 PF03092.16 EKX73834.1 - 1.2e-12 46.9 6.6 1.2e-12 46.9 6.6 1.5 1 1 1 2 2 2 1 BT1 family PUCC PF03209.15 EKX73834.1 - 0.0055 15.8 2.8 0.0092 15.0 2.8 1.4 1 1 0 1 1 1 1 PUCC protein DUF1634 PF07843.11 EKX73834.1 - 0.092 12.8 3.4 0.69 10.0 3.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1634) FAINT PF04385.15 EKX73836.1 - 8.6e-86 282.1 88.4 7.3e-06 26.0 0.0 23.1 22 0 0 22 22 22 21 Domain of unknown function, DUF529 Viral_P18 PF04521.13 EKX73836.1 - 0.0077 16.0 0.0 0.027 14.3 0.0 1.9 2 0 0 2 2 2 1 ssRNA positive strand viral 18kD cysteine rich protein Myb_DNA-binding PF00249.31 EKX73837.1 - 2.1e-10 40.6 0.0 6.5e-10 39.1 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.17 EKX73837.1 - 2.4e-05 24.1 6.5 4.6e-05 23.1 6.5 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type Baculo_IE-1 PF05290.11 EKX73837.1 - 0.0073 16.3 3.7 0.02 14.8 3.7 1.7 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) Striatin PF08232.12 EKX73838.1 - 0.079 13.5 0.4 0.079 13.5 0.4 1.7 2 0 0 2 2 2 0 Striatin family AP2 PF00847.20 EKX73838.1 - 0.1 12.9 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 AP2 domain Pkinase PF00069.25 EKX73839.1 - 7.7e-55 186.1 0.0 1.1e-54 185.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKX73839.1 - 5.7e-24 84.8 0.4 2.6e-23 82.6 0.4 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EKX73839.1 - 9.7e-05 21.5 0.4 0.00013 21.0 0.4 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EKX73839.1 - 0.00073 19.0 0.1 0.0011 18.4 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EKX73839.1 - 0.024 14.2 0.3 0.038 13.6 0.3 1.3 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 EKX73839.1 - 0.18 11.7 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family SPRY PF00622.28 EKX73842.1 - 6.1e-16 58.6 0.5 6.1e-16 58.6 0.5 2.0 2 0 0 2 2 2 1 SPRY domain LisH PF08513.11 EKX73842.1 - 0.00051 19.9 0.0 0.001 18.9 0.0 1.6 1 0 0 1 1 1 1 LisH CLTH PF10607.9 EKX73842.1 - 0.0012 18.8 0.0 0.0025 17.7 0.0 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain DUF4835 PF16119.5 EKX73844.1 - 0.043 12.9 0.2 0.058 12.5 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4835) DUF2719 PF10891.8 EKX73846.1 - 0.011 15.6 0.0 0.011 15.6 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2719) Ank_4 PF13637.6 EKX73847.1 - 6.7e-25 87.1 9.6 8.8e-10 38.9 0.2 4.4 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EKX73847.1 - 3.7e-24 85.1 1.2 4.5e-13 49.6 0.3 2.9 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Bromodomain PF00439.25 EKX73847.1 - 2.4e-17 62.8 0.1 5.5e-17 61.6 0.1 1.6 1 0 0 1 1 1 1 Bromodomain Ank_3 PF13606.6 EKX73847.1 - 2.5e-17 61.2 0.5 0.00041 20.6 0.1 5.4 6 0 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.6 EKX73847.1 - 2.7e-15 56.2 5.6 1.9e-06 28.1 0.1 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EKX73847.1 - 3.2e-12 46.3 1.0 0.0017 18.7 0.1 5.5 5 0 0 5 5 5 4 Ankyrin repeat SSURE PF11966.8 EKX73847.1 - 0.12 12.1 0.1 3.3 7.5 0.0 2.8 1 1 2 3 3 3 0 Fibronectin-binding repeat Toxin_30 PF08117.11 EKX73847.1 - 0.65 10.3 5.9 41 4.5 0.0 3.5 3 1 0 3 3 3 0 Ptu family PMM PF03332.13 EKX73848.1 - 3.4e-75 252.6 0.3 3.8e-48 164.2 0.1 2.2 2 0 0 2 2 2 2 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 EKX73848.1 - 2.4e-08 34.1 0.0 6.6e-06 26.0 0.0 2.5 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EKX73848.1 - 0.0029 17.2 0.0 0.5 9.8 0.0 2.2 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase HAD PF12710.7 EKX73848.1 - 0.27 11.6 0.4 2 8.8 0.4 2.3 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF1002 PF06207.11 EKX73849.1 - 0.063 12.8 1.4 0.094 12.2 1.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1002) DUF2785 PF10978.8 EKX73849.1 - 0.071 12.9 0.1 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2785) Yip1 PF04893.17 EKX73852.1 - 0.00045 20.0 16.8 0.00075 19.3 16.7 1.6 1 1 0 1 1 1 1 Yip1 domain Gcd10p PF04189.13 EKX73853.1 - 6.7e-40 137.1 1.1 1.2e-39 136.2 1.1 1.3 1 0 0 1 1 1 1 Gcd10p family FAINT PF04385.15 EKX73853.1 - 2.6e-11 43.4 0.2 0.03 14.4 0.0 4.0 3 0 0 3 3 3 3 Domain of unknown function, DUF529 MTS PF05175.14 EKX73853.1 - 0.0069 16.0 0.0 0.013 15.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Ribosomal_L11 PF00298.19 EKX73854.1 - 8.6e-20 71.0 0.2 1.5e-19 70.3 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 EKX73854.1 - 3.3e-19 68.5 0.1 7e-19 67.4 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Actin PF00022.19 EKX73855.1 - 1.7e-82 277.2 0.0 1.2e-81 274.5 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EKX73855.1 - 0.24 10.2 0.0 2.3 7.0 0.0 2.1 2 0 0 2 2 2 0 MreB/Mbl protein DUF1387 PF07139.11 EKX73857.1 - 0.71 9.6 9.9 1.2 8.7 9.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Es2 PF09751.9 EKX73858.1 - 6.6e-23 82.1 20.8 3.3e-13 50.2 5.6 4.4 1 1 2 3 3 3 2 Nuclear protein Es2 DUF1451 PF07295.11 EKX73860.1 - 0.083 12.9 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Zinc-ribbon containing domain Linker_histone PF00538.19 EKX73860.1 - 0.15 12.4 1.5 16 5.9 0.2 3.4 2 1 1 3 3 3 0 linker histone H1 and H5 family Rep_2 PF01719.17 EKX73860.1 - 0.45 10.3 6.2 5.7 6.7 0.2 2.7 2 0 0 2 2 2 0 Plasmid replication protein Methyltr_RsmB-F PF01189.17 EKX73861.1 - 6.9e-33 114.0 0.0 2.8e-27 95.7 0.0 2.1 1 1 1 2 2 2 2 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.6 EKX73861.1 - 0.02 14.7 0.0 0.073 12.9 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain FtsJ PF01728.19 EKX73861.1 - 0.12 12.5 0.0 0.37 10.9 0.0 1.9 1 1 0 1 1 1 0 FtsJ-like methyltransferase FAINT PF04385.15 EKX73864.1 - 3.5e-11 43.0 0.1 6.3e-11 42.2 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 Vps35 PF03635.17 EKX73866.1 - 2.8e-168 561.7 4.5 6.9e-167 557.1 2.6 2.0 2 0 0 2 2 2 2 Vacuolar protein sorting-associated protein 35 Ilm1 PF10311.9 EKX73867.1 - 0.081 12.6 0.7 0.16 11.6 0.7 1.4 1 0 0 1 1 1 0 Increased loss of mitochondrial DNA protein 1 DUF1623 PF07785.11 EKX73867.1 - 5.9 7.1 6.9 5.5 7.2 0.1 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF1623) FAINT PF04385.15 EKX73868.1 - 1e-27 96.0 7.1 5.9e-07 29.5 0.0 4.8 4 1 1 5 5 5 4 Domain of unknown function, DUF529 CwfJ_C_1 PF04677.15 EKX73868.1 - 0.083 12.8 0.0 1.4 8.8 0.0 2.4 2 0 0 2 2 2 0 Protein similar to CwfJ C-terminus 1 zf-CCCH PF00642.24 EKX73869.1 - 4.4e-09 36.0 2.7 4.4e-09 36.0 2.7 2.1 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EKX73869.1 - 8.6e-06 25.6 4.4 2.8e-05 24.0 4.4 2.0 1 0 0 1 1 1 1 Zinc finger domain zf-RING_5 PF14634.6 EKX73869.1 - 0.0003 20.7 11.0 0.00088 19.2 11.0 1.8 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_10 PF16685.5 EKX73869.1 - 0.0009 19.3 8.7 0.0014 18.7 7.3 2.1 2 0 0 2 2 2 1 zinc RING finger of MSL2 zf-CCCH_4 PF18044.1 EKX73869.1 - 0.0011 18.7 2.9 0.0028 17.4 2.9 1.7 1 0 0 1 1 1 1 CCCH-type zinc finger Prok-RING_4 PF14447.6 EKX73869.1 - 0.0022 17.8 6.4 0.005 16.7 6.4 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EKX73869.1 - 0.0026 17.6 9.6 0.0057 16.5 9.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EKX73869.1 - 0.0041 17.1 6.6 0.0099 15.9 6.6 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EKX73869.1 - 0.0042 16.9 11.0 0.01 15.7 11.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EKX73869.1 - 0.017 15.0 12.2 0.049 13.5 12.2 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Cwf_Cwc_15 PF04889.12 EKX73869.1 - 0.12 12.1 9.2 0.19 11.5 9.2 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein AF-4 PF05110.13 EKX73869.1 - 0.14 10.2 15.3 0.19 9.8 15.3 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein zf-RING_2 PF13639.6 EKX73869.1 - 0.32 11.4 10.1 0.96 9.8 10.1 1.9 1 1 0 1 1 1 0 Ring finger domain SR-25 PF10500.9 EKX73869.1 - 0.83 9.2 13.2 1.4 8.5 13.2 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein zf-P11 PF03854.14 EKX73869.1 - 1 9.1 11.4 2.5 7.8 11.4 1.6 1 0 0 1 1 1 0 P-11 zinc finger Nop53 PF07767.11 EKX73869.1 - 2 7.7 14.6 2.9 7.2 14.6 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) zf-C3HC4_4 PF15227.6 EKX73869.1 - 3.1 8.0 13.5 0.12 12.5 5.4 2.7 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING CoaE PF01121.20 EKX73870.1 - 7.9e-40 136.4 0.0 1e-39 136.0 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_33 PF13671.6 EKX73870.1 - 0.054 13.6 0.0 0.23 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EKX73870.1 - 0.073 13.6 0.0 0.16 12.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EKX73870.1 - 0.15 12.3 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EKX73870.1 - 0.18 11.6 1.0 0.41 10.4 0.3 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain ArfGap PF01412.18 EKX73871.1 - 3.6e-29 101.2 0.0 8e-29 100.1 0.0 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Apo-CIII PF05778.12 EKX73871.1 - 0.14 11.8 1.5 4.6 7.0 0.1 2.3 2 0 0 2 2 2 0 Apolipoprotein CIII (Apo-CIII) RNA_pol_Rpb1_5 PF04998.17 EKX73872.1 - 1.5e-84 283.6 0.0 2.6e-84 282.8 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EKX73872.1 - 8e-61 205.1 0.0 1.5e-60 204.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EKX73872.1 - 2.6e-28 98.9 0.2 1.1e-27 96.9 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 EKX73872.1 - 4.2e-19 69.0 4.6 3.1e-18 66.2 1.1 3.1 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 EKX73872.1 - 3.8e-13 49.3 0.0 1.4e-12 47.5 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 FAINT PF04385.15 EKX73874.1 - 6.9e-16 58.1 3.3 1e-06 28.7 1.7 2.3 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Elf1 PF05129.13 EKX73875.1 - 2.1 8.4 7.2 2.6 8.1 0.2 2.6 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like Hydrolase_4 PF12146.8 EKX73877.1 - 1.1e-17 64.1 0.0 1.1e-16 60.8 0.0 2.5 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EKX73877.1 - 6.1e-06 26.1 0.1 0.00013 21.7 0.0 3.0 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EKX73877.1 - 6.9e-06 26.8 0.0 1.7e-05 25.5 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family FAINT PF04385.15 EKX73877.1 - 1.2e-05 25.3 10.2 0.016 15.3 1.1 4.2 3 0 0 3 3 3 2 Domain of unknown function, DUF529 Peptidase_S9 PF00326.21 EKX73877.1 - 0.0085 15.6 0.0 4.3 6.7 0.0 3.0 3 0 0 3 3 3 2 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 EKX73877.1 - 0.13 12.1 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold LIDHydrolase PF10230.9 EKX73877.1 - 0.14 11.7 0.4 0.33 10.5 0.0 1.7 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase Plasmodium_Vir PF05795.11 EKX73879.1 - 3.7e-06 26.6 0.3 3.7e-06 26.6 0.3 1.6 2 0 0 2 2 2 1 Plasmodium vivax Vir protein DUF4795 PF16043.5 EKX73879.1 - 0.029 14.0 4.9 0.044 13.4 4.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) CCD48 PF15799.5 EKX73879.1 - 0.09 11.1 3.8 0.12 10.7 3.8 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 48 Bac_export_2 PF01312.19 EKX73879.1 - 2 7.5 3.5 2.9 7.0 3.5 1.2 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family PRP1_N PF06424.12 EKX73881.1 - 1.5e-29 103.3 24.8 3e-29 102.3 14.8 3.8 3 1 0 3 3 3 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 EKX73881.1 - 1.5e-17 62.8 16.4 0.0061 17.3 0.1 10.5 5 3 6 11 11 10 4 Tetratricopeptide repeat TPR_19 PF14559.6 EKX73881.1 - 1.1e-11 45.0 7.3 0.027 15.0 0.0 7.4 6 2 2 8 8 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 EKX73881.1 - 9.8e-07 29.3 2.7 1.3 9.7 1.3 6.3 5 2 1 6 6 5 2 Tetratricopeptide repeat TPR_21 PF09976.9 EKX73881.1 - 4.7e-05 23.2 4.8 0.024 14.4 0.3 3.5 2 1 1 3 3 3 1 Tetratricopeptide repeat-like domain TPR_17 PF13431.6 EKX73881.1 - 0.00012 22.2 1.3 4.3 7.9 0.0 6.5 7 1 0 7 7 5 1 Tetratricopeptide repeat DUF3808 PF10300.9 EKX73881.1 - 0.00051 18.9 0.2 5.8 5.5 0.0 3.9 3 1 1 4 4 4 2 Protein of unknown function (DUF3808) ANAPC3 PF12895.7 EKX73881.1 - 0.00094 19.4 1.5 0.019 15.2 0.2 3.5 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 EKX73881.1 - 0.0024 17.2 10.6 0.46 9.6 2.3 4.8 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 EKX73881.1 - 0.0092 16.0 15.6 5.5 7.3 0.2 7.0 8 0 0 8 8 7 1 Tetratricopeptide repeat PMT2_N PF17987.1 EKX73881.1 - 0.042 14.0 0.1 0.093 12.9 0.1 1.5 1 0 0 1 1 1 0 Phosphoethanolamine N-methyltransferase 2 N-terminal TPR_12 PF13424.6 EKX73881.1 - 0.059 13.7 5.2 6.9 7.0 0.4 5.1 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 EKX73881.1 - 0.063 13.0 12.8 29 4.5 0.1 8.1 9 0 0 9 9 9 0 TPR repeat TPR_4 PF07721.14 EKX73881.1 - 0.3 11.8 1.9 17 6.4 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2802 PF10975.8 EKX73881.1 - 0.37 11.0 2.4 5.9 7.1 0.3 3.3 3 1 1 4 4 3 0 Protein of unknown function (DUF2802) HHH PF00633.23 EKX73881.1 - 1.6 8.7 0.0 1.6 8.7 0.0 3.5 4 0 0 4 4 4 0 Helix-hairpin-helix motif NRDE-2 PF08424.10 EKX73881.1 - 2.7 7.0 17.1 0.27 10.3 0.6 4.0 2 1 1 4 4 4 0 NRDE-2, necessary for RNA interference VSP PF03302.13 EKX73883.1 - 9.6e-05 21.4 0.1 9.6e-05 21.4 0.1 1.5 2 0 0 2 2 2 1 Giardia variant-specific surface protein TPR_19 PF14559.6 EKX73883.1 - 0.00031 21.2 0.1 4.7 7.8 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EKX73883.1 - 0.0019 18.3 0.2 4.7 7.7 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EKX73883.1 - 0.0029 18.3 1.9 2 9.5 0.0 3.6 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 EKX73883.1 - 0.004 17.2 0.2 3.4 8.0 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EKX73883.1 - 0.032 14.9 0.2 5.2 7.8 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat G-patch PF01585.23 EKX73884.1 - 1.1e-16 60.4 0.2 1.1e-16 60.4 0.2 1.5 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 EKX73884.1 - 7.4e-08 32.4 0.2 7.4e-08 32.4 0.2 1.6 2 0 0 2 2 2 1 G-patch domain zf-Tim10_DDP PF02953.15 EKX73888.1 - 2.7e-18 65.4 1.3 3.6e-18 65.0 1.3 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger FAST_1 PF06743.15 EKX73890.1 - 3.4e-09 36.5 18.4 0.0037 17.2 0.9 6.1 5 2 2 7 7 7 4 FAST kinase-like protein, subdomain 1 HNOB PF07700.15 EKX73890.1 - 0.044 13.7 0.2 0.18 11.8 0.2 2.0 1 0 0 1 1 1 0 Haem-NO-binding PhaP_Bmeg PF09602.10 EKX73890.1 - 0.051 13.5 3.3 3.5 7.5 0.1 2.5 2 0 0 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Collagen PF01391.18 EKX73891.1 - 7.5 6.4 37.8 0.23 11.3 11.9 3.1 3 0 0 3 3 3 0 Collagen triple helix repeat (20 copies) Asp PF00026.23 EKX73893.1 - 1e-33 117.1 1.3 4.9e-33 114.9 1.3 2.1 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EKX73893.1 - 9.9e-07 29.2 0.2 0.00056 20.2 0.1 3.2 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal AAA_23 PF13476.6 EKX73895.1 - 0.0015 19.1 0.0 0.0027 18.3 0.0 1.5 1 1 0 1 1 1 1 AAA domain YlbD_coat PF14071.6 EKX73895.1 - 0.12 12.7 2.3 0.21 11.8 2.3 1.3 1 0 0 1 1 1 0 Putative coat protein UQ_con PF00179.26 EKX73896.1 - 1.3e-37 128.5 0.0 1.6e-37 128.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EKX73896.1 - 0.15 11.8 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B SNF2_N PF00176.23 EKX73897.1 - 1.2e-48 165.7 0.0 3.5e-48 164.1 0.0 1.8 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EKX73897.1 - 3.5e-15 56.3 0.0 1e-14 54.8 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKX73897.1 - 2.4e-07 30.9 0.0 0.0005 20.1 0.0 3.2 4 0 0 4 4 4 2 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EKX73897.1 - 0.014 14.6 0.1 0.05 12.8 0.0 2.0 2 1 0 2 2 2 0 Class II histone deacetylase complex subunits 2 and 3 Myb_DNA-bind_4 PF13837.6 EKX73897.1 - 0.032 14.6 0.4 0.27 11.6 0.7 2.4 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain DUF2075 PF09848.9 EKX73897.1 - 0.044 13.0 0.0 0.13 11.5 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 EKX73897.1 - 0.17 12.2 0.0 0.46 10.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain LSM PF01423.22 EKX73898.1 - 1.5e-20 72.6 0.0 1.7e-20 72.5 0.0 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EKX73898.1 - 0.016 15.3 0.0 0.018 15.2 0.0 1.1 1 0 0 1 1 1 0 Ataxin 2 SM domain DUF3437 PF11919.8 EKX73899.1 - 0.2 11.6 1.9 7.4 6.6 0.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) Ufd2P_core PF10408.9 EKX73900.1 - 1.2e-127 427.2 18.8 1.8e-127 426.6 18.8 1.3 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 EKX73900.1 - 2.2e-23 82.2 0.3 5.2e-23 81.0 0.3 1.7 1 0 0 1 1 1 1 U-box domain Phage_TAC_12 PF12363.8 EKX73900.1 - 0.036 14.5 0.0 0.21 12.0 0.0 2.3 1 0 0 1 1 1 0 Phage tail assembly chaperone protein, TAC DUF3525 PF12039.8 EKX73900.1 - 0.078 11.7 0.1 6 5.5 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3525) YMF19 PF02326.15 EKX73900.1 - 0.53 11.1 4.1 0.6 10.9 0.2 3.2 3 0 0 3 3 3 0 Plant ATP synthase F0 zf-CCCH PF00642.24 EKX73902.1 - 3.2e-05 23.7 13.8 0.00096 19.0 0.1 4.4 4 0 0 4 4 4 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EKX73902.1 - 0.00012 21.8 11.7 0.0066 16.2 0.1 4.2 4 0 0 4 4 4 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EKX73902.1 - 0.0048 16.9 0.6 0.0048 16.9 0.6 4.0 4 0 0 4 4 4 1 Zinc finger domain Pro_isomerase PF00160.21 EKX73903.1 - 2.6e-47 161.0 0.0 5.1e-47 160.1 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 EKX73903.1 - 1.5e-09 38.3 2.1 0.00029 21.6 0.1 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EKX73903.1 - 0.0015 17.6 0.5 0.36 9.7 0.0 2.7 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 EKX73903.1 - 0.017 15.4 0.0 1 9.7 0.0 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain VID27 PF08553.10 EKX73903.1 - 0.027 13.5 0.0 0.068 12.2 0.0 1.6 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain HHH_2 PF12826.7 EKX73904.1 - 0.064 13.4 0.0 0.18 11.9 0.0 1.7 2 0 0 2 2 2 0 Helix-hairpin-helix motif TauE PF01925.19 EKX73905.1 - 5.9e-23 81.7 20.9 1.1e-12 48.1 14.1 2.1 1 1 1 2 2 2 2 Sulfite exporter TauE/SafE Pho88 PF10032.9 EKX73905.1 - 0.00078 18.7 0.4 0.0042 16.4 0.0 2.3 1 1 1 2 2 2 1 Phosphate transport (Pho88) Glycophorin_A PF01102.18 EKX73905.1 - 0.34 11.1 2.4 13 6.1 0.1 3.2 3 0 0 3 3 3 0 Glycophorin A tRNA-synt_2 PF00152.20 EKX73906.1 - 8.4e-70 235.3 0.0 1.1e-69 234.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EKX73906.1 - 1.2e-08 34.8 0.4 4.3e-08 33.0 0.3 2.0 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EKX73906.1 - 0.00027 20.5 0.0 0.0058 16.1 0.1 2.2 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) PI3_PI4_kinase PF00454.27 EKX73907.1 - 1.3e-29 103.8 0.1 2.7e-20 73.2 0.1 2.6 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EKX73907.1 - 2.1e-09 37.1 0.7 4e-09 36.1 0.7 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Nse4_C PF08743.10 EKX73908.1 - 1.3e-05 25.4 0.0 6.6e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Nse4 C-terminal FerA PF08165.11 EKX73908.1 - 0.005 16.8 0.6 0.011 15.7 0.6 1.5 1 0 0 1 1 1 1 FerA (NUC095) domain DEAD PF00270.29 EKX73909.1 - 3.4e-46 157.2 0.0 6.4e-46 156.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKX73909.1 - 6.3e-21 74.8 0.3 1.5e-18 67.1 0.1 3.2 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EKX73909.1 - 4.1e-14 52.5 0.2 9.1e-14 51.4 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EKX73909.1 - 3.5e-07 30.4 0.0 8.7e-07 29.1 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit RAMPs PF03787.15 EKX73910.1 - 0.0087 16.1 10.1 7.2 6.6 10.0 3.5 1 1 0 1 1 1 1 RAMP superfamily SLATT_4 PF18186.1 EKX73910.1 - 0.074 12.7 7.1 11 5.7 0.2 3.9 2 1 1 4 4 4 0 SMODS and SLOG-associating 2TM effector domain family 4 DUF5377 PF17347.2 EKX73910.1 - 0.61 10.5 8.8 45 4.5 0.0 6.3 6 2 3 9 9 9 0 Family of unknown function (DUF5377) Pkinase PF00069.25 EKX73911.1 - 5.1e-18 65.4 0.0 2e-16 60.1 0.0 2.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKX73911.1 - 6.2e-13 48.6 0.0 1.4e-11 44.2 0.0 2.5 2 0 0 2 2 2 1 Protein tyrosine kinase RabGAP-TBC PF00566.18 EKX73911.1 - 1.7e-12 47.4 4.3 3.1e-12 46.6 2.5 2.3 3 0 0 3 3 3 1 Rab-GTPase-TBC domain Kinase-like PF14531.6 EKX73911.1 - 5.7e-06 25.8 0.0 2.3e-05 23.9 0.0 1.9 1 1 0 1 1 1 1 Kinase-like Rhodanese PF00581.20 EKX73911.1 - 0.0039 17.7 0.0 0.0099 16.4 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain RRM_1 PF00076.22 EKX73913.1 - 9.1e-11 41.4 0.2 1.4e-05 24.8 0.1 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EKX73913.1 - 0.013 15.6 0.1 0.03 14.4 0.1 1.7 1 0 0 1 1 1 0 RNA recognition motif BRAP2 PF07576.12 EKX73913.1 - 0.025 14.8 0.1 0.16 12.2 0.0 2.2 2 0 0 2 2 2 0 BRCA1-associated protein 2 TraV PF09676.10 EKX73913.1 - 0.13 13.2 5.1 0.075 14.0 2.6 1.9 2 0 0 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) RPA43_OB PF17875.1 EKX73913.1 - 0.68 10.6 5.3 0.26 11.9 2.1 1.9 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I WBS_methylT PF12589.8 EKX73913.1 - 2.2 9.1 13.2 27 5.6 9.2 2.6 2 0 0 2 2 2 0 Methyltransferase involved in Williams-Beuren syndrome DUF1168 PF06658.12 EKX73913.1 - 7 6.5 18.0 0.37 10.6 11.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) SRP9-21 PF05486.12 EKX73914.1 - 1.9e-05 24.9 0.8 0.0012 19.2 0.8 2.2 1 1 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) FRB_dom PF08771.11 EKX73914.1 - 0.049 14.1 0.1 0.054 13.9 0.1 1.1 1 0 0 1 1 1 0 FKBP12-rapamycin binding domain NMD3 PF04981.13 EKX73915.1 - 9.2e-50 169.4 4.1 9.2e-50 169.4 4.1 1.6 2 0 0 2 2 2 1 NMD3 family FtsJ PF01728.19 EKX73916.1 - 3.3e-56 190.2 0.2 5.4e-56 189.5 0.2 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Brix PF04427.18 EKX73916.1 - 8.9e-33 114.0 3.4 8.2e-32 110.9 0.4 2.3 2 0 0 2 2 2 2 Brix domain Adaptin_N PF01602.20 EKX73917.1 - 2.4e-64 217.8 18.7 3.1e-64 217.4 18.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EKX73917.1 - 1.1e-26 93.8 7.0 7.1e-24 84.7 3.4 2.7 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 EKX73917.1 - 2.7e-07 30.6 0.1 9.9e-07 28.8 0.0 2.0 2 0 0 2 2 2 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.6 EKX73917.1 - 8e-05 22.9 0.0 0.23 11.9 0.0 3.8 3 1 2 5 5 5 2 HEAT repeats AAA_6 PF12774.7 EKX73919.1 - 5.6e-73 245.8 0.0 5.6e-73 245.8 0.0 2.2 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EKX73919.1 - 2.7e-37 128.8 14.3 2.7e-37 128.8 14.3 5.2 3 1 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 MT PF12777.7 EKX73919.1 - 1.7e-15 56.9 14.1 1.7e-15 56.9 14.1 1.8 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 EKX73919.1 - 2.8e-10 40.3 0.7 3.2e-09 36.9 0.1 3.2 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain AAA_5 PF07728.14 EKX73919.1 - 1.1e-07 32.0 0.0 0.027 14.5 0.0 3.9 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_lid_11 PF18198.1 EKX73919.1 - 0.00029 20.7 0.6 0.0014 18.5 0.1 2.4 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_18 PF13238.6 EKX73919.1 - 0.0013 19.3 0.1 0.73 10.4 0.0 4.7 4 0 0 4 4 4 1 AAA domain AAA PF00004.29 EKX73919.1 - 0.0075 16.7 0.1 0.26 11.7 0.0 3.6 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EKX73919.1 - 0.027 14.2 0.1 0.69 9.6 0.1 2.3 2 0 0 2 2 2 0 AAA domain Flp_N PF03930.14 EKX73919.1 - 0.031 14.2 1.9 0.8 9.7 0.0 4.3 3 0 0 3 3 3 0 Recombinase Flp protein N-terminus DUF3446 PF11928.8 EKX73919.1 - 0.2 11.9 5.7 0.91 9.9 3.0 2.8 2 0 0 2 2 2 0 Early growth response N-terminal domain ABC_tran PF00005.27 EKX73919.1 - 0.72 10.4 2.7 70 3.9 0.0 4.8 4 0 0 4 4 4 0 ABC transporter Prok-RING_4 PF14447.6 EKX73920.1 - 3.2e-07 30.1 5.2 8.3e-07 28.8 5.2 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EKX73920.1 - 3.7e-07 30.0 5.1 9.1e-07 28.7 5.1 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EKX73920.1 - 4e-07 30.0 4.3 9.3e-07 28.8 4.3 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EKX73920.1 - 8.9e-06 25.5 4.5 1.9e-05 24.4 4.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EKX73920.1 - 1.2e-05 25.3 2.6 2.7e-05 24.2 2.6 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EKX73920.1 - 2.5e-05 24.5 5.4 5.8e-05 23.3 5.4 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EKX73920.1 - 0.0001 22.1 5.9 0.00025 20.8 5.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EKX73920.1 - 0.00089 19.1 6.3 0.0024 17.7 6.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 EKX73920.1 - 0.018 14.8 3.3 0.041 13.7 3.3 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain CLTH PF10607.9 EKX73920.1 - 0.038 13.9 0.4 0.31 10.9 0.1 2.6 3 0 0 3 3 3 0 CTLH/CRA C-terminal to LisH motif domain zf-RING_10 PF16685.5 EKX73920.1 - 4.3 7.5 6.6 10 6.4 6.6 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-C3HC4_3 PF13920.6 EKX73921.1 - 0.006 16.4 10.5 0.006 16.4 10.5 3.3 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-Di19 PF05605.12 EKX73921.1 - 0.018 15.4 19.5 0.71 10.2 0.1 5.2 4 1 0 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding Elf1 PF05129.13 EKX73922.1 - 0.04 14.0 5.5 0.38 10.8 0.1 4.3 4 0 0 4 4 4 0 Transcription elongation factor Elf1 like Hydrolase_4 PF12146.8 EKX73924.1 - 2.7e-23 82.5 0.0 2.7e-22 79.2 0.0 2.4 2 1 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX73924.1 - 3.8e-13 49.3 10.9 9e-05 22.5 0.0 4.2 4 0 0 4 4 4 3 Domain of unknown function, DUF529 Abhydrolase_1 PF00561.20 EKX73924.1 - 3.9e-07 30.0 1.5 0.00049 19.8 1.3 2.7 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EKX73924.1 - 7.3e-06 25.6 0.0 0.0014 18.2 0.0 2.4 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EKX73924.1 - 0.00035 21.2 0.0 0.00074 20.2 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 EKX73924.1 - 0.002 17.7 0.1 0.019 14.5 0.0 2.1 2 0 0 2 2 2 1 Putative serine esterase (DUF676) Abhydrolase_3 PF07859.13 EKX73924.1 - 0.002 18.0 0.0 0.032 14.1 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 EKX73924.1 - 0.006 16.5 0.0 1 9.2 0.0 2.3 2 0 0 2 2 2 1 Serine hydrolase Abhydrolase_2 PF02230.16 EKX73924.1 - 0.012 15.4 0.8 0.46 10.2 0.1 2.6 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase DUF900 PF05990.12 EKX73924.1 - 0.016 14.7 0.0 0.036 13.6 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) PGAP1 PF07819.13 EKX73924.1 - 0.024 14.4 0.1 0.085 12.6 0.1 2.0 2 0 0 2 2 2 0 PGAP1-like protein LCAT PF02450.15 EKX73924.1 - 0.029 13.5 0.1 0.058 12.5 0.1 1.4 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase LIDHydrolase PF10230.9 EKX73924.1 - 0.12 11.9 0.3 0.24 10.9 0.3 1.5 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Hydrolase_3 PF08282.12 EKX73926.1 - 8.3e-43 147.0 0.0 9.9e-43 146.7 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EKX73926.1 - 2.1e-09 37.3 0.0 1.6e-05 24.6 0.0 2.2 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EKX73926.1 - 2.5e-06 27.9 0.0 1e-05 25.9 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EKX73926.1 - 0.023 15.1 0.0 0.34 11.3 0.0 2.3 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EKX73926.1 - 0.037 14.2 0.0 0.091 12.9 0.0 1.7 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EKX73926.1 - 0.1 12.7 0.0 0.82 9.7 0.0 2.2 2 1 1 3 3 3 0 Haloacid dehalogenase-like hydrolase DUF2740 PF10872.8 EKX73926.1 - 0.15 12.0 0.2 1.5 8.7 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2740) FAINT PF04385.15 EKX73927.1 - 5.1e-14 52.1 6.3 3.1e-08 33.6 0.9 2.5 2 0 0 2 2 2 2 Domain of unknown function, DUF529 EABR PF12180.8 EKX73927.1 - 0.017 14.8 0.3 0.037 13.6 0.0 1.7 2 0 0 2 2 2 0 TSG101 and ALIX binding domain of CEP55 Corona_S2 PF01601.16 EKX73927.1 - 0.63 8.5 2.5 0.91 7.9 2.5 1.2 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Peptidase_C1 PF00112.23 EKX73929.1 - 5e-59 200.0 0.1 7.2e-59 199.5 0.1 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EKX73929.1 - 9.8e-06 24.6 0.1 0.0031 16.3 0.0 2.3 2 0 0 2 2 2 2 Peptidase C1-like family Inhibitor_I29 PF08246.12 EKX73929.1 - 1.1e-05 25.8 6.4 1.1e-05 25.8 6.4 2.1 2 0 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) REC1 PF18501.1 EKX73929.1 - 0.05 13.5 0.1 0.076 12.9 0.1 1.2 1 0 0 1 1 1 0 Alpha helical recognition lobe domain FAD_binding_1 PF00667.20 EKX73930.1 - 2.7e-16 59.8 0.2 1.2e-14 54.4 0.1 2.8 3 0 0 3 3 3 1 FAD binding domain Flavodoxin_1 PF00258.25 EKX73930.1 - 1.4e-14 54.5 0.0 2.9e-14 53.5 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin DUF2685 PF10886.8 EKX73930.1 - 0.054 13.7 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2685) NAD_binding_1 PF00175.21 EKX73930.1 - 0.19 12.3 0.1 0.63 10.7 0.1 1.8 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain zf-Tim10_DDP PF02953.15 EKX73931.1 - 0.02 14.5 1.8 3.2 7.5 0.3 2.4 2 0 0 2 2 2 0 Tim10/DDP family zinc finger COBRA1 PF06209.13 EKX73932.1 - 0.0012 17.9 0.1 0.0025 16.7 0.1 1.5 1 0 0 1 1 1 1 Cofactor of BRCA1 (COBRA1) Transglut_core PF01841.19 EKX73934.1 - 0.01 16.3 0.0 0.013 15.9 0.0 1.2 1 0 0 1 1 1 0 Transglutaminase-like superfamily tRNA_int_endo PF01974.17 EKX73936.1 - 7.3e-20 70.8 0.0 8e-20 70.7 0.0 1.0 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain XRN_N PF03159.18 EKX73937.1 - 5.6e-64 215.9 0.0 8.8e-64 215.2 0.0 1.3 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 EKX73937.1 - 7e-63 213.1 2.8 3.6e-44 151.4 1.1 2.2 1 1 1 2 2 2 2 Xrn1 helical domain Sterile PF03015.19 EKX73937.1 - 0.0094 16.2 0.0 0.027 14.7 0.0 1.7 1 0 0 1 1 1 1 Male sterility protein Nup54 PF13874.6 EKX73938.1 - 3.4e-07 30.5 2.4 6e-07 29.7 1.9 1.8 1 1 0 1 1 1 1 Nucleoporin complex subunit 54 ParE_toxin PF05016.15 EKX73938.1 - 0.012 16.2 0.5 0.93 10.2 0.1 2.7 2 0 0 2 2 2 0 ParE toxin of type II toxin-antitoxin system, parDE Arc_C PF18162.1 EKX73938.1 - 0.038 13.8 0.2 1.2 9.1 0.0 2.5 2 0 0 2 2 2 0 Arc C-lobe FTCD_C PF04961.12 EKX73938.1 - 0.15 11.8 1.0 0.24 11.2 0.3 1.8 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase SwrA PF17423.2 EKX73938.1 - 1.1 9.2 6.3 9.3 6.3 0.1 3.4 1 1 3 4 4 4 0 Swarming motility protein AKNA PF12443.8 EKX73938.1 - 4 8.2 6.9 14 6.4 0.2 2.9 2 1 0 2 2 2 0 AT-hook-containing transcription factor UQ_con PF00179.26 EKX73939.1 - 2.8e-22 78.9 0.0 3.3e-22 78.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme FAINT PF04385.15 EKX73940.1 - 1e-36 124.8 7.9 9.2e-08 32.0 0.3 5.5 5 0 0 5 5 5 5 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73941.1 - 1.7e-09 37.6 0.1 5e-05 23.3 0.3 2.7 2 0 0 2 2 2 2 Domain of unknown function, DUF529 EMA PF02488.15 EKX73941.1 - 0.00053 19.7 0.4 0.0092 15.7 0.2 2.4 2 1 0 2 2 2 1 Merozoite Antigen FAINT PF04385.15 EKX73942.1 - 1.6e-08 34.5 0.0 0.00014 21.9 0.0 2.4 2 1 0 2 2 2 2 Domain of unknown function, DUF529 Pallilysin PF18663.1 EKX73942.1 - 0.12 12.3 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 Pallilysin beta barrel domain ABC_tran PF00005.27 EKX73944.1 - 1.3e-29 103.4 0.0 4.3e-16 59.7 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_29 PF13555.6 EKX73944.1 - 2.3e-05 24.0 2.5 0.062 13.0 0.2 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EKX73944.1 - 3.8e-05 24.1 0.0 0.084 13.2 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EKX73944.1 - 5.5e-05 23.1 0.6 0.02 14.8 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 EKX73944.1 - 0.00019 21.4 0.5 0.08 12.7 0.0 3.0 3 0 0 3 3 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 EKX73944.1 - 0.00023 20.9 0.0 0.16 11.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain DUF87 PF01935.17 EKX73944.1 - 0.0013 18.9 1.9 0.12 12.5 0.0 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain FtsK_SpoIIIE PF01580.18 EKX73944.1 - 0.0016 17.8 0.5 0.2 11.0 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family MMR_HSR1 PF01926.23 EKX73944.1 - 0.0022 18.1 0.1 0.13 12.4 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase MeaB PF03308.16 EKX73944.1 - 0.004 16.2 0.2 0.053 12.5 0.0 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 EKX73944.1 - 0.0041 16.4 0.2 0.71 9.1 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin SMC_N PF02463.19 EKX73944.1 - 0.0043 16.5 0.5 0.089 12.2 0.1 2.4 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EKX73944.1 - 0.0046 17.2 0.0 1 9.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EKX73944.1 - 0.009 16.6 0.0 4.7 7.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EKX73944.1 - 0.021 13.9 0.2 6.4 5.7 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein DnaB_C PF03796.15 EKX73944.1 - 0.031 13.6 0.0 0.67 9.2 0.0 2.2 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain ATPase_2 PF01637.18 EKX73944.1 - 0.043 13.7 0.0 4.2 7.2 0.0 2.7 3 0 0 3 3 2 0 ATPase domain predominantly from Archaea AAA_23 PF13476.6 EKX73944.1 - 0.054 14.0 10.5 0.69 10.4 0.4 2.8 3 0 0 3 3 2 0 AAA domain IstB_IS21 PF01695.17 EKX73944.1 - 0.054 13.2 0.7 3.1 7.5 0.0 3.3 4 0 0 4 4 4 0 IstB-like ATP binding protein DUF815 PF05673.13 EKX73944.1 - 0.055 12.6 0.1 0.59 9.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) NACHT PF05729.12 EKX73944.1 - 0.067 13.1 0.3 14 5.6 0.0 2.5 2 0 0 2 2 2 0 NACHT domain ATP_bind_1 PF03029.17 EKX73944.1 - 0.078 12.7 0.1 11 5.7 0.0 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein NB-ARC PF00931.22 EKX73944.1 - 0.14 11.4 0.4 1 8.5 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain RNA_helicase PF00910.22 EKX73944.1 - 0.14 12.5 0.0 19 5.7 0.0 2.9 2 0 0 2 2 2 0 RNA helicase AAA_25 PF13481.6 EKX73944.1 - 0.15 11.6 0.0 3.4 7.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 EKX73944.1 - 0.16 11.6 2.0 3.4 7.3 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain Fer4_NifH PF00142.18 EKX73944.1 - 0.17 11.3 0.3 10 5.4 0.0 2.3 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Dynamin_N PF00350.23 EKX73944.1 - 0.2 11.7 1.6 5.2 7.1 0.1 2.5 2 0 0 2 2 2 0 Dynamin family AAA PF00004.29 EKX73945.1 - 2e-43 148.0 0.1 5.2e-43 146.6 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EKX73945.1 - 5.7e-11 42.2 0.0 1.2e-10 41.1 0.0 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EKX73945.1 - 6e-10 38.8 0.2 1.2e-09 37.8 0.2 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 EKX73945.1 - 2.4e-06 27.8 0.0 5.3e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EKX73945.1 - 3.8e-06 27.2 0.2 0.01 16.1 0.1 2.8 1 1 1 2 2 2 2 AAA domain AAA_5 PF07728.14 EKX73945.1 - 1.3e-05 25.2 0.3 0.00014 21.9 0.1 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EKX73945.1 - 2.5e-05 24.1 0.0 5e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 EKX73945.1 - 4.3e-05 22.8 0.0 8.3e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 EKX73945.1 - 5.4e-05 23.2 0.0 0.012 15.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EKX73945.1 - 8.3e-05 23.0 0.0 0.0015 19.0 0.0 2.3 1 1 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 EKX73945.1 - 0.0019 17.9 0.0 0.0054 16.5 0.0 1.7 2 0 0 2 2 1 1 IstB-like ATP binding protein NTPase_1 PF03266.15 EKX73945.1 - 0.0035 17.3 1.1 0.21 11.5 0.0 3.0 3 0 0 3 3 3 1 NTPase RNA_helicase PF00910.22 EKX73945.1 - 0.0045 17.4 0.0 0.01 16.2 0.0 1.7 1 0 0 1 1 1 1 RNA helicase TIP49 PF06068.13 EKX73945.1 - 0.0045 16.2 0.0 0.011 15.0 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_18 PF13238.6 EKX73945.1 - 0.0049 17.4 0.0 0.01 16.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EKX73945.1 - 0.0052 17.0 0.0 0.0097 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EKX73945.1 - 0.0064 16.8 0.1 0.015 15.5 0.0 1.7 2 0 0 2 2 1 1 AAA domain Mg_chelatase PF01078.21 EKX73945.1 - 0.014 14.8 0.1 0.032 13.6 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PhoH PF02562.16 EKX73945.1 - 0.02 14.3 0.2 0.12 11.8 0.1 2.0 2 0 0 2 2 2 0 PhoH-like protein AAA_24 PF13479.6 EKX73945.1 - 0.032 14.0 1.9 0.18 11.5 1.9 2.3 1 1 0 1 1 1 0 AAA domain AAA_3 PF07726.11 EKX73945.1 - 0.038 13.9 0.0 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EKX73945.1 - 0.042 13.8 0.1 0.49 10.3 0.0 2.4 2 1 1 3 3 2 0 NACHT domain AAA_17 PF13207.6 EKX73945.1 - 0.049 14.1 0.4 0.2 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EKX73945.1 - 0.054 13.0 0.1 0.15 11.6 0.1 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region ATPase_2 PF01637.18 EKX73945.1 - 0.055 13.4 0.6 1.8 8.4 0.0 2.8 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea Cas_St_Csn2 PF16813.5 EKX73945.1 - 0.068 12.3 0.1 0.11 11.6 0.1 1.2 1 0 0 1 1 1 0 CRISPR-associated protein Csn2 subfamily St Sigma54_activat PF00158.26 EKX73945.1 - 0.098 12.4 0.2 0.81 9.4 0.0 2.3 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_25 PF13481.6 EKX73945.1 - 0.099 12.2 0.0 0.33 10.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain Bac_DnaA PF00308.18 EKX73945.1 - 0.11 12.3 0.5 0.62 9.9 0.5 2.0 1 1 0 1 1 1 0 Bacterial dnaA protein Parvo_NS1 PF01057.17 EKX73945.1 - 0.11 11.5 0.1 0.28 10.2 0.0 1.6 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_30 PF13604.6 EKX73945.1 - 0.12 12.1 0.2 0.28 10.9 0.2 1.6 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EKX73945.1 - 0.15 12.6 0.2 0.38 11.3 0.2 2.0 1 1 0 1 1 1 0 ABC transporter TsaE PF02367.17 EKX73945.1 - 0.15 12.0 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Syntaxin-6_N PF09177.11 EKX73946.1 - 3.2e-17 62.9 3.2 3.2e-17 62.9 3.2 2.0 2 1 0 2 2 2 1 Syntaxin 6, N-terminal DUF5082 PF16888.5 EKX73946.1 - 0.00012 22.4 5.9 0.00012 22.4 5.9 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF5082) ATG16 PF08614.11 EKX73946.1 - 0.0024 18.1 9.3 0.026 14.7 0.3 2.1 2 0 0 2 2 2 2 Autophagy protein 16 (ATG16) FPP PF05911.11 EKX73946.1 - 0.016 13.5 8.3 0.57 8.3 3.3 2.0 2 0 0 2 2 2 0 Filament-like plant protein, long coiled-coil LXG PF04740.12 EKX73946.1 - 0.017 14.9 9.5 0.011 15.4 4.6 2.4 1 1 2 3 3 3 0 LXG domain of WXG superfamily APG17 PF04108.12 EKX73946.1 - 0.018 14.2 4.1 0.37 9.9 0.8 2.1 1 1 1 2 2 2 0 Autophagy protein Apg17 DUF848 PF05852.11 EKX73946.1 - 0.026 14.6 0.9 0.053 13.6 0.3 1.7 1 1 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) SesA PF17107.5 EKX73946.1 - 0.029 14.5 0.6 0.059 13.6 0.6 1.6 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases PTE PF02126.18 EKX73946.1 - 0.05 13.0 0.0 0.061 12.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotriesterase family NPV_P10 PF05531.12 EKX73946.1 - 0.053 14.0 3.2 0.34 11.4 0.0 2.7 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein ArsR PF09824.9 EKX73946.1 - 0.12 12.0 4.0 1 8.9 0.1 2.6 1 1 2 3 3 3 0 ArsR transcriptional regulator TMF_TATA_bd PF12325.8 EKX73946.1 - 0.15 12.3 9.6 0.28 11.4 4.3 2.8 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DHR10 PF18595.1 EKX73946.1 - 0.49 10.5 11.3 0.37 10.8 3.0 3.3 2 2 2 4 4 4 0 Designed helical repeat protein 10 domain Cauli_AT PF03233.13 EKX73946.1 - 0.6 10.0 6.8 0.69 9.8 4.1 2.1 2 0 0 2 2 2 0 Aphid transmission protein TMPIT PF07851.13 EKX73946.1 - 0.98 8.6 6.6 3.9 6.6 2.1 2.1 2 0 0 2 2 2 0 TMPIT-like protein Prefoldin_2 PF01920.20 EKX73946.1 - 3 7.8 8.9 1.5 8.9 1.3 3.1 1 1 2 3 3 3 0 Prefoldin subunit HemX PF04375.14 EKX73946.1 - 3.6 6.8 11.0 5.1 6.3 3.2 2.1 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase BRX_N PF13713.6 EKX73948.1 - 0.12 12.2 0.1 0.28 11.0 0.1 1.6 1 0 0 1 1 1 0 Transcription factor BRX N-terminal domain Rossmann-like PF10727.9 EKX73949.1 - 0.028 14.3 0.1 0.055 13.3 0.1 1.4 1 0 0 1 1 1 0 Rossmann-like domain mTERF PF02536.14 EKX73951.1 - 1.5e-14 53.6 0.5 4.4e-14 52.1 0.1 1.8 2 0 0 2 2 2 1 mTERF FAINT PF04385.15 EKX73952.1 - 1.1e-25 89.5 11.9 6.6e-05 22.9 0.2 6.6 7 0 0 7 7 7 6 Domain of unknown function, DUF529 Myosin-VI_CBD PF16521.5 EKX73952.1 - 3.5e-05 23.7 0.1 7.1 6.7 0.0 3.4 3 0 0 3 3 3 3 Myosin VI cargo binding domain TarS_C1 PF18674.1 EKX73952.1 - 0.00084 19.3 0.0 2.2 8.2 0.0 2.8 3 0 0 3 3 3 2 TarS beta-glycosyltransferase C-terminal domain 1 Sin3_corepress PF08295.12 EKX73952.1 - 0.19 11.8 0.0 0.45 10.6 0.0 1.6 1 0 0 1 1 1 0 Sin3 family co-repressor IF3_C PF00707.22 EKX73955.1 - 0.00099 19.0 0.2 0.0015 18.4 0.1 1.4 1 1 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain XPG_I PF00867.18 EKX73956.1 - 6.6e-11 42.4 0.0 1.6e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 EKX73956.1 - 0.027 15.0 0.0 0.053 14.0 0.0 1.5 1 0 0 1 1 1 0 XPG N-terminal domain KH_1 PF00013.29 EKX73957.1 - 0.00014 21.6 0.2 0.37 10.6 0.0 2.9 3 0 0 3 3 3 2 KH domain Hydrolase_3 PF08282.12 EKX73959.1 - 7.2e-40 137.3 0.0 9.2e-40 137.0 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EKX73959.1 - 4.6e-07 29.6 0.0 0.0017 17.9 0.0 2.3 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EKX73959.1 - 0.0036 17.6 0.0 0.0074 16.6 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EKX73959.1 - 0.024 15.1 0.0 0.085 13.3 0.0 1.8 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EKX73959.1 - 0.027 14.5 0.0 0.5 10.4 0.0 2.2 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase SRP54 PF00448.22 EKX73960.1 - 3.4e-77 258.5 0.2 6e-77 257.7 0.2 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EKX73960.1 - 6.9e-28 97.2 0.2 6.9e-28 97.2 0.2 2.5 3 0 0 3 3 2 1 Signal peptide binding domain SRP54_N PF02881.19 EKX73960.1 - 1.2e-17 63.9 2.8 3.7e-17 62.3 2.8 1.9 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 EKX73960.1 - 1.1e-05 25.1 0.1 5e-05 23.0 0.1 2.0 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 EKX73960.1 - 5e-05 22.4 0.0 0.00016 20.8 0.0 1.8 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 EKX73960.1 - 0.00016 22.1 0.0 0.00034 21.0 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 EKX73960.1 - 0.0012 19.0 0.0 0.0051 17.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EKX73960.1 - 0.0014 17.9 0.0 0.0035 16.7 0.0 1.6 2 0 0 2 2 2 1 Zeta toxin ResIII PF04851.15 EKX73960.1 - 0.0016 18.5 0.6 0.065 13.2 0.2 3.1 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit Fe-ADH PF00465.19 EKX73960.1 - 0.0025 16.7 0.0 0.0064 15.3 0.0 1.7 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase AAA_30 PF13604.6 EKX73960.1 - 0.0034 17.1 0.1 0.015 15.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 EKX73960.1 - 0.0064 16.5 0.0 0.018 15.1 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain APS_kinase PF01583.20 EKX73960.1 - 0.011 15.6 0.1 0.034 14.1 0.0 1.8 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_17 PF13207.6 EKX73960.1 - 0.015 15.7 0.8 0.059 13.8 0.1 2.3 2 1 0 2 2 2 0 AAA domain VirE PF05272.11 EKX73960.1 - 0.017 14.9 0.0 0.034 13.9 0.0 1.4 1 0 0 1 1 1 0 Virulence-associated protein E AAA_22 PF13401.6 EKX73960.1 - 0.02 15.2 0.1 0.081 13.2 0.0 2.2 2 0 0 2 2 1 0 AAA domain ATPase PF06745.13 EKX73960.1 - 0.03 13.7 0.3 0.14 11.5 0.0 2.2 1 1 1 2 2 2 0 KaiC PduV-EutP PF10662.9 EKX73960.1 - 0.059 13.1 0.5 7.6 6.3 0.0 2.8 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 EKX73960.1 - 0.31 11.2 1.7 1.5 8.9 0.3 2.7 2 1 0 2 2 2 0 50S ribosome-binding GTPase ArsA_ATPase PF02374.15 EKX73960.1 - 7.8 5.6 9.7 0.52 9.4 0.1 3.5 3 2 1 4 4 4 0 Anion-transporting ATPase FAINT PF04385.15 EKX73962.1 - 0.00013 21.9 6.4 0.0019 18.2 1.0 2.6 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Endonuc-MspI PF09208.10 EKX73962.1 - 0.066 12.6 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Restriction endonuclease MspI PI3_PI4_kinase PF00454.27 EKX73963.1 - 6.5e-30 104.7 4.7 3.9e-20 72.7 0.1 3.7 3 1 1 4 4 4 3 Phosphatidylinositol 3- and 4-kinase FAINT PF04385.15 EKX73963.1 - 1.3e-13 50.7 16.4 1.9e-05 24.7 0.4 5.0 4 0 0 4 4 4 3 Domain of unknown function, DUF529 PI3Ka PF00613.20 EKX73963.1 - 1.5e-09 37.5 0.7 3.8e-09 36.2 0.7 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) EIF_2_alpha PF07541.12 EKX73965.1 - 1.4e-28 99.3 0.0 2.7e-28 98.4 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 EKX73965.1 - 5.1e-11 42.8 0.5 1.6e-10 41.2 0.5 1.8 1 0 0 1 1 1 1 S1 RNA binding domain EcKinase PF02958.20 EKX73965.1 - 0.029 13.7 0.3 0.065 12.5 0.1 1.6 2 0 0 2 2 2 0 Ecdysteroid kinase RepL PF05732.11 EKX73965.1 - 0.038 13.4 0.6 1.6 8.1 0.3 2.2 2 0 0 2 2 2 0 Firmicute plasmid replication protein (RepL) TPR_12 PF13424.6 EKX73966.1 - 2.3e-16 59.8 5.2 8.5e-08 32.4 0.0 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EKX73966.1 - 3.9e-08 32.9 14.8 0.025 14.7 0.0 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 EKX73966.1 - 5.3e-07 29.3 6.1 0.00053 19.8 0.5 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EKX73966.1 - 1.4e-06 28.0 12.4 0.0061 16.6 1.0 4.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 EKX73966.1 - 1.4e-06 27.9 3.0 0.0021 18.0 0.2 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat MIT PF04212.18 EKX73966.1 - 0.00097 19.2 0.2 0.00097 19.2 0.2 2.5 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain TPR_1 PF00515.28 EKX73966.1 - 0.012 15.4 15.7 0.24 11.3 1.9 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 EKX73966.1 - 0.047 14.1 1.3 28 5.4 0.2 4.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EKX73966.1 - 0.12 13.3 0.0 25 6.0 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat S_layer_N PF05123.12 EKX73967.1 - 0.0079 16.1 0.0 0.0094 15.8 0.0 1.1 1 0 0 1 1 1 1 S-layer like family, N-terminal region FAINT PF04385.15 EKX73968.1 - 1.8e-12 47.2 2.9 1.2e-05 25.3 0.1 2.6 2 1 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX73971.1 - 4.5e-11 42.6 0.0 3.4e-06 27.0 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function, DUF529 ABC_tran PF00005.27 EKX73972.1 - 1.6e-29 103.2 0.0 4.8e-16 59.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_29 PF13555.6 EKX73972.1 - 1.1e-05 25.1 0.5 0.12 12.2 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EKX73972.1 - 4.5e-05 23.4 0.7 0.31 10.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EKX73972.1 - 5.8e-05 23.5 0.0 0.039 14.4 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EKX73972.1 - 0.00026 20.9 0.9 0.076 12.9 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_18 PF13238.6 EKX73972.1 - 0.00048 20.7 0.2 1.6 9.3 0.1 2.7 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EKX73972.1 - 0.00054 19.7 0.1 0.16 11.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 EKX73972.1 - 0.00067 19.8 2.9 0.094 12.8 0.1 3.0 3 0 0 3 3 3 1 Helicase HerA, central domain Zeta_toxin PF06414.12 EKX73972.1 - 0.001 18.4 0.2 0.37 10.1 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin Dynamin_N PF00350.23 EKX73972.1 - 0.002 18.2 0.6 0.37 10.8 0.0 2.6 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EKX73972.1 - 0.0031 17.6 0.1 0.2 11.8 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase DnaB_C PF03796.15 EKX73972.1 - 0.0038 16.6 0.0 0.26 10.6 0.0 2.3 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain MeaB PF03308.16 EKX73972.1 - 0.0053 15.8 0.7 0.047 12.7 0.1 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 EKX73972.1 - 0.0055 17.0 0.1 0.55 10.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 EKX73972.1 - 0.0075 15.6 0.5 0.86 8.9 0.1 2.2 2 0 0 2 2 2 1 FtsK/SpoIIIE family SMC_N PF02463.19 EKX73972.1 - 0.0082 15.6 0.3 0.11 11.9 0.0 2.3 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain T2SSE PF00437.20 EKX73972.1 - 0.024 13.7 0.7 2.8 6.9 0.1 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_15 PF13175.6 EKX73972.1 - 0.026 14.2 0.7 6.4 6.4 0.1 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 EKX73972.1 - 0.03 14.8 3.8 3.1 8.2 0.1 2.8 3 0 0 3 3 2 0 AAA domain ATP_bind_1 PF03029.17 EKX73972.1 - 0.04 13.7 0.1 6.1 6.6 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein NACHT PF05729.12 EKX73972.1 - 0.055 13.4 0.3 11 5.9 0.1 2.5 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.6 EKX73972.1 - 0.085 12.4 0.0 2.1 7.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EKX73972.1 - 0.1 13.0 0.0 17 5.8 0.0 3.2 3 0 0 3 3 2 0 RNA helicase NB-ARC PF00931.22 EKX73972.1 - 0.18 10.9 0.5 1.4 8.0 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain cobW PF02492.19 EKX73972.1 - 0.58 9.7 2.6 9.1 5.8 0.0 2.8 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain Peptidase_C1 PF00112.23 EKX73973.1 - 3.3e-48 164.7 2.4 3.3e-48 164.7 2.4 1.6 2 0 0 2 2 2 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EKX73973.1 - 1.3e-07 30.8 0.5 0.00012 21.0 0.1 2.3 2 0 0 2 2 2 2 Peptidase C1-like family Inhibitor_I29 PF08246.12 EKX73973.1 - 0.043 14.3 0.6 0.12 12.9 0.6 1.8 1 0 0 1 1 1 0 Cathepsin propeptide inhibitor domain (I29) RR_TM4-6 PF06459.12 EKX73973.1 - 0.64 9.8 10.1 1 9.1 10.1 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 O-antigen_lig PF13425.6 EKX73973.1 - 0.74 8.5 3.5 1.2 7.9 3.5 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF1980 PF09323.10 EKX73973.1 - 2.6 7.9 8.3 36 4.2 8.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF1980) GET2 PF08690.10 EKX73973.1 - 4.4 6.9 9.3 7.4 6.2 9.3 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 RVT_1 PF00078.27 EKX73975.1 - 3.6e-35 121.5 0.4 7e-35 120.5 0.1 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) PGK PF00162.19 EKX73978.1 - 3.7e-09 36.0 0.3 3.7e-09 36.0 0.3 1.1 1 0 0 1 1 1 1 Phosphoglycerate kinase PNPase_C PF12111.8 EKX73979.1 - 0.096 12.1 1.2 0.18 11.3 1.2 1.4 1 0 0 1 1 1 0 Polyribonucleotide phosphorylase C terminal Gal_Lectin PF02140.18 EKX73979.1 - 0.28 11.6 2.2 0.82 10.1 0.4 2.6 2 1 0 2 2 2 0 Galactose binding lectin domain G-patch PF01585.23 EKX73980.1 - 1.3e-15 57.0 2.2 3.2e-15 55.8 2.2 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EKX73980.1 - 0.0062 16.6 0.6 0.019 15.1 0.6 1.8 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 EKX73980.1 - 0.13 12.1 0.0 20 5.1 0.0 2.7 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Gar1 PF04410.14 EKX73981.1 - 6.3e-23 81.3 1.3 2.1e-22 79.6 1.2 1.7 2 0 0 2 2 2 1 Gar1/Naf1 RNA binding region RNA_pol_Rbc25 PF08292.12 EKX73981.1 - 0.17 12.1 0.9 0.26 11.5 0.9 1.3 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 TFIIS_C PF01096.18 EKX73983.1 - 1.5e-13 50.4 2.2 1.5e-13 50.4 2.2 2.4 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) Baculo_LEF5_C PF11792.8 EKX73983.1 - 0.00048 19.7 1.0 0.00048 19.7 1.0 2.2 3 0 0 3 3 2 1 Baculoviridae late expression factor 5 C-terminal domain DUF2757 PF10955.8 EKX73983.1 - 0.002 18.3 3.2 0.52 10.6 0.0 3.8 4 0 0 4 4 4 1 Protein of unknown function (DUF2757) E7 PF00527.18 EKX73983.1 - 0.005 17.0 2.1 0.1 12.8 0.0 3.0 2 1 0 2 2 2 1 E7 protein, Early protein zf-Sec23_Sec24 PF04810.15 EKX73983.1 - 0.005 16.9 2.3 1.9 8.6 0.0 3.9 4 0 0 4 4 4 1 Sec23/Sec24 zinc finger tRNA-synt_1f PF01921.18 EKX73983.1 - 0.07 12.0 0.5 0.36 9.7 0.1 1.9 2 0 0 2 2 2 0 tRNA synthetases class I (K) zinc_ribbon_2 PF13240.6 EKX73983.1 - 0.074 12.8 2.3 9.5 6.1 0.1 2.8 2 0 0 2 2 2 0 zinc-ribbon domain PHD_4 PF16866.5 EKX73983.1 - 0.074 13.1 2.3 3.3 7.9 1.2 2.5 2 0 0 2 2 2 0 PHD-finger DUF3268 PF11672.8 EKX73983.1 - 0.4 11.0 2.8 3 8.2 0.6 2.3 2 0 0 2 2 2 0 zinc-finger-containing domain DZR PF12773.7 EKX73983.1 - 0.51 10.4 6.4 0.43 10.6 0.6 2.9 2 1 0 2 2 2 0 Double zinc ribbon Rubredoxin_2 PF18073.1 EKX73983.1 - 0.57 9.9 6.9 5.6 6.8 0.2 3.4 3 0 0 3 3 3 0 Rubredoxin metal binding domain Ribosomal_L44 PF00935.19 EKX73983.1 - 0.72 10.4 4.8 8.6 6.9 0.3 2.9 3 0 0 3 3 3 0 Ribosomal protein L44 DNA_RNApol_7kD PF03604.13 EKX73983.1 - 1.3 8.8 9.7 9.2 6.0 0.0 3.6 4 0 0 4 4 4 0 DNA directed RNA polymerase, 7 kDa subunit zinc_ribbon_15 PF17032.5 EKX73983.1 - 1.5 9.6 9.4 15 6.4 2.2 3.7 2 1 1 3 3 3 0 zinc-ribbon family PHD PF00628.29 EKX73983.1 - 1.9 8.4 7.9 2 8.4 1.2 2.9 3 0 0 3 3 3 0 PHD-finger zf-DNL PF05180.12 EKX73983.1 - 4.1 7.4 8.0 0.23 11.4 1.4 2.3 3 0 0 3 3 3 0 DNL zinc finger PTH2 PF01981.16 EKX73984.1 - 2.2e-41 140.8 0.0 3e-41 140.4 0.0 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 UCR_14kD PF02271.16 EKX73985.1 - 2.1e-18 66.1 0.0 3.1e-18 65.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Hydrolase_3 PF08282.12 EKX73986.1 - 5.6e-26 91.8 0.0 8.3e-26 91.2 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EKX73986.1 - 0.00032 20.3 0.0 0.034 13.7 0.0 2.7 3 0 0 3 3 3 2 Sucrose-6F-phosphate phosphohydrolase FAINT PF04385.15 EKX73986.1 - 0.0021 18.0 0.8 0.0058 16.7 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function, DUF529 GMP_synt_C PF00958.22 EKX73987.1 - 2.8e-30 104.2 0.1 7.7e-30 102.8 0.1 1.8 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 EKX73987.1 - 4.2e-24 85.4 0.0 9e-24 84.3 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 EKX73987.1 - 9e-07 28.2 0.1 5.9e-06 25.6 0.0 2.0 2 0 0 2 2 2 1 NAD synthase tRNA_Me_trans PF03054.16 EKX73987.1 - 0.0022 16.8 0.0 0.0035 16.2 0.0 1.2 1 0 0 1 1 1 1 tRNA methyl transferase Peptidase_C26 PF07722.13 EKX73987.1 - 0.0084 15.9 0.2 0.056 13.2 0.2 2.2 1 1 0 1 1 1 1 Peptidase C26 Asn_synthase PF00733.21 EKX73987.1 - 0.025 14.2 0.1 0.06 13.0 0.0 1.6 2 0 0 2 2 2 0 Asparagine synthase QueC PF06508.13 EKX73987.1 - 0.12 11.8 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC Thioredoxin PF00085.20 EKX73988.1 - 6.4e-52 173.9 0.4 1.6e-30 105.2 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 EKX73988.1 - 3.8e-12 46.6 1.2 4.7e-07 30.2 0.0 3.5 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_6 PF13848.6 EKX73988.1 - 4.8e-10 39.6 0.0 2.7e-05 24.2 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EKX73988.1 - 7.6e-09 35.8 1.3 0.008 16.5 0.1 4.8 3 2 2 5 5 5 2 Thioredoxin-like OST3_OST6 PF04756.13 EKX73988.1 - 1.1e-07 31.5 0.0 1.2e-06 28.1 0.0 2.3 2 1 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 EKX73988.1 - 7.1e-07 29.3 1.3 0.014 15.6 0.1 2.7 2 1 0 2 2 2 2 Thioredoxin-like TraF PF13728.6 EKX73988.1 - 6e-06 26.2 0.2 0.021 14.7 0.0 2.7 2 2 0 2 2 2 2 F plasmid transfer operon protein Thioredoxin_9 PF14595.6 EKX73988.1 - 1.4e-05 24.8 0.0 0.0062 16.3 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_3 PF13192.6 EKX73988.1 - 0.00021 21.3 0.3 0.37 10.9 0.1 2.6 3 0 0 3 3 3 2 Thioredoxin domain Thioredoxin_5 PF13743.6 EKX73988.1 - 0.026 14.2 0.2 17 5.0 0.1 3.4 2 2 2 4 4 4 0 Thioredoxin Thioredoxin_4 PF13462.6 EKX73988.1 - 0.087 13.0 3.5 3.4 7.8 0.4 3.3 2 2 2 4 4 4 0 Thioredoxin FAINT PF04385.15 EKX73990.1 - 5.2e-05 23.2 1.7 8.3e-05 22.6 1.0 1.8 1 1 0 1 1 1 1 Domain of unknown function, DUF529 Ricin_B_lectin PF00652.22 EKX73990.1 - 0.082 13.2 0.0 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 Ricin-type beta-trefoil lectin domain RRM_1 PF00076.22 EKX73992.1 - 1.5e-31 108.0 0.0 2.5e-18 65.6 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EKX73992.1 - 1.8e-07 31.1 0.0 0.0076 16.3 0.0 2.3 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.6 EKX73992.1 - 0.00086 19.3 0.1 0.0023 17.9 0.1 1.7 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EKX73992.1 - 0.0011 19.0 0.1 0.0041 17.2 0.1 2.0 1 1 0 1 1 1 1 RNA recognition motif PHM7_cyt PF14703.6 EKX73992.1 - 0.0075 16.5 0.1 1.7 8.9 0.0 2.6 2 1 1 3 3 3 1 Cytosolic domain of 10TM putative phosphate transporter RRM_occluded PF16842.5 EKX73992.1 - 0.0098 15.7 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 1 Occluded RNA-recognition motif RlmM_FDX PF18125.1 EKX73992.1 - 0.021 15.3 0.4 0.16 12.4 0.0 2.2 2 0 0 2 2 2 0 RlmM ferredoxin-like domain FAINT PF04385.15 EKX73993.1 - 3.8e-12 46.1 4.5 1.5e-05 24.9 1.8 2.5 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Collagen_bind_2 PF12904.7 EKX73993.1 - 0.018 15.0 0.0 0.063 13.3 0.0 1.9 1 0 0 1 1 1 0 Putative collagen-binding domain of a collagenase Phage_head_chap PF11113.8 EKX73993.1 - 0.038 14.1 0.0 0.12 12.4 0.0 1.9 1 0 0 1 1 1 0 Head assembly gene product Macoilin PF09726.9 EKX73996.1 - 2.4 6.6 4.3 3.6 6.0 4.3 1.2 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 EKX73996.1 - 3.5 6.4 6.0 6.9 5.4 4.7 1.9 2 0 0 2 2 2 0 Golgi-body localisation protein domain SNF2_N PF00176.23 EKX73997.1 - 1.2e-59 201.8 0.1 1.2e-59 201.8 0.1 2.9 3 1 1 4 4 4 1 SNF2 family N-terminal domain Chromo PF00385.24 EKX73997.1 - 2.4e-25 88.2 4.4 7.6e-12 45.0 0.5 2.9 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 EKX73997.1 - 8.9e-21 74.3 0.0 2e-20 73.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 EKX73997.1 - 2.1e-11 43.6 0.4 4.1e-11 42.6 0.4 1.4 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 EKX73997.1 - 3.1e-09 37.1 0.0 2e-07 31.1 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EKX73997.1 - 7e-06 25.9 0.0 4e-05 23.4 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Myb_DNA-binding PF00249.31 EKX73997.1 - 0.0041 17.3 0.4 0.38 11.0 0.0 3.5 3 0 0 3 3 3 1 Myb-like DNA-binding domain Mtf2_C PF14061.6 EKX73997.1 - 0.0093 16.1 0.1 0.18 12.0 0.0 2.5 2 0 0 2 2 2 1 Polycomb-like MTF2 factor 2 AAA_22 PF13401.6 EKX73997.1 - 0.12 12.6 0.3 1.8 8.8 0.0 3.0 3 0 0 3 3 3 0 AAA domain Chromo_shadow PF01393.19 EKX73997.1 - 0.14 12.2 0.0 7.5 6.7 0.0 2.6 2 0 0 2 2 2 0 Chromo shadow domain CDH1_2_SANT_HL1 PF18375.1 EKX73997.1 - 1.7 9.4 5.9 0.32 11.7 0.8 2.6 2 0 0 2 2 1 0 CDH1/2 SANT-Helical linker 1 FAINT PF04385.15 EKX73999.1 - 1.1e-07 31.8 3.6 0.00099 19.1 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Phage_T4_Ndd PF06591.11 EKX73999.1 - 0.099 12.4 0.0 0.26 11.0 0.0 1.7 1 0 0 1 1 1 0 T4-like phage nuclear disruption protein (Ndd) Nucleoporin_FG PF13634.6 EKX74001.1 - 6.7e-29 100.6 180.9 1.1e-07 32.5 16.0 10.1 2 2 7 9 9 9 8 Nucleoporin FG repeat region DUF5320 PF17253.2 EKX74002.1 - 2.2 9.4 4.1 11 7.2 1.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5320) UBA PF00627.31 EKX74004.1 - 7.8e-23 80.0 13.6 2.4e-12 46.5 1.8 3.8 4 0 0 4 4 4 2 UBA/TS-N domain XPC-binding PF09280.11 EKX74004.1 - 1e-19 70.0 8.6 1e-19 70.0 8.6 2.2 2 0 0 2 2 2 1 XPC-binding domain ubiquitin PF00240.23 EKX74004.1 - 1.9e-15 56.4 2.2 4.3e-15 55.2 2.2 1.6 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EKX74004.1 - 1e-06 28.4 2.6 2.5e-06 27.2 2.6 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EKX74004.1 - 0.00072 20.1 0.1 0.0015 19.1 0.1 1.5 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain UBA_3 PF09288.10 EKX74004.1 - 0.05 13.4 0.0 8.1 6.3 0.0 3.0 2 0 0 2 2 2 0 Fungal ubiquitin-associated domain Not1 PF04054.15 EKX74004.1 - 0.053 12.4 0.5 0.11 11.3 0.2 1.7 1 1 1 2 2 2 0 CCR4-Not complex component, Not1 DUF4012 PF13196.6 EKX74004.1 - 0.069 13.6 0.4 0.14 12.7 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4012) Rad60-SLD_2 PF13881.6 EKX74004.1 - 0.1 12.7 0.5 0.23 11.6 0.5 1.6 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Rap1_C PF11626.8 EKX74004.1 - 0.15 12.2 0.0 1.4 9.0 0.0 2.5 3 0 0 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain ACT_5 PF13710.6 EKX74004.1 - 0.23 11.3 1.4 0.51 10.2 1.4 1.6 1 0 0 1 1 1 0 ACT domain KH_1 PF00013.29 EKX74005.1 - 5.7e-08 32.5 1.1 0.00073 19.3 0.1 5.8 7 0 0 7 7 7 1 KH domain SLS PF14611.6 EKX74005.1 - 7.5e-05 22.7 2.4 0.022 14.6 0.0 2.8 2 0 0 2 2 2 2 Mitochondrial inner-membrane-bound regulator TAFII55_N PF04658.13 EKX74005.1 - 0.025 14.3 0.6 0.1 12.3 0.1 2.2 2 0 0 2 2 2 0 TAFII55 protein conserved region KH_4 PF13083.6 EKX74005.1 - 0.089 12.7 0.2 0.47 10.4 0.2 2.3 1 0 0 1 1 1 0 KH domain Phasin PF05597.11 EKX74005.1 - 0.12 12.4 1.2 0.36 10.8 0.1 2.4 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) ALS2CR8 PF15299.6 EKX74006.1 - 0.03 14.2 0.0 0.043 13.7 0.0 1.2 1 0 0 1 1 1 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 Proteasome PF00227.26 EKX74007.1 - 7.8e-47 159.2 0.1 9.3e-47 159.0 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Peptidase_C1 PF00112.23 EKX74010.1 - 2.1e-27 96.6 0.3 3.7e-27 95.9 0.3 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EKX74010.1 - 0.0019 18.6 0.6 0.0048 17.3 0.6 1.8 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Nup88 PF10168.9 EKX74010.1 - 0.13 10.0 1.6 0.19 9.5 1.6 1.1 1 0 0 1 1 1 0 Nuclear pore component Prominin PF05478.11 EKX74010.1 - 5.2 4.9 6.2 0.42 8.5 1.0 1.6 1 1 1 2 2 2 0 Prominin FAINT PF04385.15 EKX74011.1 - 0.048 13.7 0.1 0.27 11.3 0.0 2.2 2 1 0 2 2 2 0 Domain of unknown function, DUF529 FAINT PF04385.15 EKX74012.1 - 2.6e-16 59.4 14.8 3.5e-06 27.0 0.1 4.6 4 1 1 5 5 5 3 Domain of unknown function, DUF529 Lamp PF01299.17 EKX74012.1 - 0.048 13.5 1.1 0.082 12.7 0.2 1.8 2 0 0 2 2 2 0 Lysosome-associated membrane glycoprotein (Lamp) OAD_gamma PF04277.13 EKX74012.1 - 4.6 7.9 4.7 1.6 9.4 0.3 2.3 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain FAINT PF04385.15 EKX74013.1 - 0.00013 22.0 1.0 0.0027 17.7 0.1 3.0 3 1 0 3 3 3 1 Domain of unknown function, DUF529 nlz1 PF12402.8 EKX74013.1 - 0.12 12.8 0.0 0.21 12.0 0.0 1.3 1 0 0 1 1 1 0 NocA-like zinc-finger protein 1 SRP_SPB PF02978.19 EKX74014.1 - 0.06 14.0 0.2 0.5 11.0 0.0 2.3 2 0 0 2 2 2 0 Signal peptide binding domain DUF1247 PF06851.11 EKX74014.1 - 0.32 10.9 4.0 3.2 7.7 0.1 3.1 1 1 2 4 4 4 0 Protein of unknown function (DUF1247) Ras PF00071.22 EKX74015.1 - 3.9e-58 195.6 0.1 4.7e-58 195.4 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKX74015.1 - 1.6e-33 115.4 0.0 2.4e-33 114.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKX74015.1 - 6.2e-12 45.3 0.0 7.8e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKX74015.1 - 3.3e-06 27.2 0.0 7e-06 26.1 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKX74015.1 - 0.00012 21.7 0.1 0.0007 19.2 0.1 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EKX74015.1 - 0.00039 19.9 0.0 0.00049 19.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DNA_pol_E_B PF04042.16 EKX74015.1 - 0.002 17.5 0.0 0.0026 17.1 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B RsgA_GTPase PF03193.16 EKX74015.1 - 0.0026 17.7 0.0 0.91 9.4 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EKX74015.1 - 0.035 14.4 0.0 0.073 13.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EKX74015.1 - 0.097 12.4 0.2 0.23 11.2 0.0 1.7 1 1 1 2 2 2 0 AAA domain RRM_1 PF00076.22 EKX74017.1 - 4.3e-31 106.5 0.6 1.5e-14 53.5 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EKX74017.1 - 1.3e-09 38.0 0.6 0.0012 18.9 0.0 2.9 2 2 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.11 EKX74017.1 - 1.9e-05 24.6 0.2 0.29 11.2 0.0 2.4 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.6 EKX74017.1 - 0.0018 18.3 2.9 0.74 9.9 0.3 2.9 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif RL PF17797.1 EKX74017.1 - 0.0082 16.1 1.0 1.4 8.9 0.1 2.8 2 1 0 2 2 2 1 RL domain OB_RNB PF08206.11 EKX74017.1 - 0.017 14.8 3.0 2 8.2 0.0 3.0 2 1 0 2 2 2 0 Ribonuclease B OB domain Apt1 PF10351.9 EKX74017.1 - 5.5 5.7 10.4 6.9 5.4 10.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain RIO1 PF01163.22 EKX74018.1 - 1.2e-65 220.6 0.2 2.8e-65 219.4 0.2 1.6 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 EKX74018.1 - 0.0024 16.7 0.3 0.0037 16.1 0.3 1.5 1 1 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EKX74018.1 - 0.013 15.5 0.0 0.41 10.5 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family CK_II_beta PF01214.18 EKX74019.1 - 3.5e-69 232.3 1.2 4.4e-69 232.0 1.2 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit ADK_lid PF05191.14 EKX74019.1 - 0.016 15.1 0.9 0.047 13.7 0.9 1.8 1 0 0 1 1 1 0 Adenylate kinase, active site lid IBR PF01485.21 EKX74019.1 - 0.044 14.0 0.3 0.11 12.7 0.3 1.6 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Baculo_PEP_C PF04513.12 EKX74020.1 - 0.19 11.8 0.2 11 6.0 0.0 2.5 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Rad51 PF08423.11 EKX74021.1 - 1.3e-05 24.6 0.1 6.3e-05 22.4 0.1 2.1 1 1 0 1 1 1 1 Rad51 AAA_16 PF13191.6 EKX74021.1 - 8.1e-05 23.1 0.0 0.00016 22.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EKX74021.1 - 0.00027 21.2 0.0 0.00071 19.9 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA PF00004.29 EKX74021.1 - 0.00041 20.8 0.0 0.0045 17.4 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EKX74021.1 - 0.0015 18.3 0.0 0.0047 16.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EKX74021.1 - 0.0077 16.8 0.1 0.026 15.1 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EKX74021.1 - 0.0078 16.2 0.0 0.032 14.3 0.0 2.1 2 0 0 2 2 1 1 AAA domain Cytidylate_kin PF02224.18 EKX74021.1 - 0.009 15.8 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 Cytidylate kinase Rad17 PF03215.15 EKX74021.1 - 0.0098 15.8 0.2 0.019 14.9 0.1 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain RNA_helicase PF00910.22 EKX74021.1 - 0.015 15.7 0.0 0.051 14.0 0.0 1.9 2 0 0 2 2 1 0 RNA helicase AAA_5 PF07728.14 EKX74021.1 - 0.021 14.8 0.0 0.043 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ATPase_2 PF01637.18 EKX74021.1 - 0.022 14.7 0.0 0.046 13.6 0.0 1.8 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 EKX74021.1 - 0.026 15.1 0.2 0.048 14.2 0.2 1.8 1 1 0 1 1 1 0 ABC transporter PhoH PF02562.16 EKX74021.1 - 0.033 13.6 0.1 0.3 10.5 0.0 2.1 2 0 0 2 2 2 0 PhoH-like protein T2SSE PF00437.20 EKX74021.1 - 0.044 12.8 0.0 0.08 12.0 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF87 PF01935.17 EKX74021.1 - 0.085 12.9 0.1 0.45 10.6 0.0 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_33 PF13671.6 EKX74021.1 - 0.099 12.8 0.0 0.19 11.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 EKX74021.1 - 0.11 12.1 0.1 0.42 10.3 0.0 1.9 2 0 0 2 2 2 0 Thymidylate kinase IstB_IS21 PF01695.17 EKX74021.1 - 0.12 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.6 EKX74021.1 - 0.13 11.9 0.1 0.56 9.7 0.1 2.1 2 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EKX74021.1 - 0.14 11.5 0.1 0.25 10.6 0.1 1.3 1 0 0 1 1 1 0 Zeta toxin RuvB_N PF05496.12 EKX74021.1 - 0.14 11.9 0.0 0.33 10.7 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain CobU PF02283.16 EKX74021.1 - 0.14 11.7 0.0 0.8 9.2 0.0 2.1 2 0 0 2 2 2 0 Cobinamide kinase / cobinamide phosphate guanyltransferase ATPase PF06745.13 EKX74021.1 - 0.15 11.4 0.6 0.35 10.2 0.1 1.8 2 0 0 2 2 2 0 KaiC HCV_core PF01542.18 EKX74022.1 - 0.0065 16.8 0.0 3.1 8.2 0.0 2.4 2 0 0 2 2 2 2 Hepatitis C virus core protein AAA_assoc_2 PF16193.5 EKX74022.1 - 0.024 15.0 0.0 0.069 13.5 0.0 1.8 1 0 0 1 1 1 0 AAA C-terminal domain eIF-5a PF01287.20 EKX74023.1 - 5.4e-24 84.1 0.0 7.5e-24 83.6 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 EKX74023.1 - 5.5e-05 23.1 0.1 8.4e-05 22.5 0.1 1.3 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain zf-Tim10_DDP PF02953.15 EKX74024.1 - 2.6e-18 65.4 0.0 3.3e-18 65.1 0.0 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Cyto_heme_lyase PF01265.17 EKX74025.1 - 9e-38 130.5 1.4 4.7e-37 128.2 1.4 1.8 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase DUF5040 PF16443.5 EKX74025.1 - 0.11 11.8 0.2 0.12 11.8 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5040) KH_1 PF00013.29 EKX74026.1 - 1.9e-05 24.4 0.4 5.4e-05 22.9 0.4 1.8 1 0 0 1 1 1 1 KH domain KH_8 PF17903.1 EKX74026.1 - 0.027 14.5 1.3 0.031 14.4 0.1 1.7 2 0 0 2 2 2 0 Krr1 KH1 domain Ribosomal_L23eN PF03939.13 EKX74026.1 - 0.24 11.7 5.3 0.54 10.5 5.3 1.6 1 0 0 1 1 1 0 Ribosomal protein L23, N-terminal domain Reticulon PF02453.17 EKX74027.1 - 1.2e-08 35.1 2.5 1.6e-08 34.7 2.5 1.2 1 0 0 1 1 1 1 Reticulon DUF639 PF04842.12 EKX74027.1 - 0.02 14.3 0.2 0.027 13.9 0.2 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) Pex24p PF06398.11 EKX74027.1 - 4.3 6.2 7.4 0.1 11.5 1.1 1.5 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin tRNA_synt_1c_R2 PF04557.15 EKX74028.1 - 0.25 12.3 0.0 0.4 11.6 0.0 1.3 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Med7 PF05983.11 EKX74029.1 - 8.2e-23 81.5 0.6 9.3e-23 81.3 0.6 1.0 1 0 0 1 1 1 1 MED7 protein Peptidase_S37 PF05576.11 EKX74029.1 - 0.036 12.7 0.0 0.04 12.6 0.0 1.1 1 0 0 1 1 1 0 PS-10 peptidase S37 Ribosomal_L4 PF00573.22 EKX74030.1 - 2.5e-51 174.1 0.0 3.8e-51 173.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family GN3L_Grn1 PF08701.11 EKX74030.1 - 0.63 10.2 7.4 0.21 11.7 1.2 2.7 3 0 0 3 3 3 0 GNL3L/Grn1 putative GTPase Sec61_beta PF03911.16 EKX74031.1 - 0.0031 17.5 0.1 0.0041 17.1 0.1 1.2 1 0 0 1 1 1 1 Sec61beta family Plasmod_dom_1 PF09715.10 EKX74031.1 - 0.087 12.9 0.1 0.11 12.5 0.1 1.1 1 0 0 1 1 1 0 Plasmodium protein of unknown function (Plasmod_dom_1) ATP-synt_S1 PF05827.12 EKX74031.1 - 0.12 12.2 0.7 0.15 11.9 0.7 1.1 1 0 0 1 1 1 0 Vacuolar ATP synthase subunit S1 (ATP6S1) CLP1_P PF16575.5 EKX74033.1 - 7.5e-20 71.5 0.2 2.4e-14 53.6 0.0 2.7 1 1 1 2 2 2 2 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 EKX74033.1 - 4.7e-19 68.4 0.0 1.3e-18 67.0 0.0 1.8 2 0 0 2 2 2 1 N-terminal beta-sandwich domain of polyadenylation factor AAA_16 PF13191.6 EKX74033.1 - 0.01 16.2 0.0 0.02 15.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 EKX74033.1 - 0.075 12.8 0.1 11 5.7 0.0 3.2 4 0 0 4 4 4 0 AAA domain COG5 PF10392.9 EKX74037.1 - 0.0036 17.5 5.4 0.0083 16.3 0.1 3.1 3 0 0 3 3 3 1 Golgi transport complex subunit 5 RNase_PH PF01138.21 EKX74038.1 - 1.6e-09 38.4 0.1 2.8e-09 37.6 0.1 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 DNA_pol_B PF00136.21 EKX74039.1 - 2.7e-130 435.2 0.3 1.9e-129 432.4 0.1 2.1 2 0 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EKX74039.1 - 1.3e-74 251.4 2.2 1.9e-74 250.8 2.2 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EKX74039.1 - 3.4e-06 27.4 1.6 8.6e-06 26.1 1.6 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 EKX74039.1 - 0.0017 17.3 0.1 0.0032 16.4 0.1 1.5 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral Noc2 PF03715.13 EKX74040.1 - 1.4e-56 192.0 2.0 3.6e-56 190.6 2.0 1.7 1 0 0 1 1 1 1 Noc2p family DUF2457 PF10446.9 EKX74040.1 - 0.016 14.4 5.7 0.024 13.8 5.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CwfJ_C_1 PF04677.15 EKX74041.1 - 4.4e-25 87.9 2.0 7.4e-25 87.2 2.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 RRM_1 PF00076.22 EKX74041.1 - 1.5e-06 27.9 0.0 6.5e-06 25.9 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CHCH PF06747.13 EKX74043.1 - 0.0029 17.7 0.8 0.0043 17.1 0.8 1.2 1 0 0 1 1 1 1 CHCH domain AGH PF17558.2 EKX74044.1 - 0.022 14.9 0.1 0.022 14.9 0.1 1.5 2 0 0 2 2 2 0 Androgenic gland hormone Syja_N PF02383.18 EKX74045.1 - 1.4e-65 221.7 0.1 2e-65 221.2 0.1 1.2 1 0 0 1 1 1 1 SacI homology domain Cyclin_N PF00134.23 EKX74046.1 - 0.0028 17.4 2.2 0.12 12.1 2.2 2.9 1 1 0 1 1 1 1 Cyclin, N-terminal domain s48_45 PF07422.13 EKX74047.1 - 0.01 16.4 3.2 0.014 15.9 3.2 1.2 1 0 0 1 1 1 0 Sexual stage antigen s48/45 domain DUF4512 PF14975.6 EKX74047.1 - 0.17 12.7 1.7 2.3 9.1 1.7 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4512) RNase_PH_C PF03725.15 EKX74048.1 - 3e-05 23.9 0.1 8.3e-05 22.5 0.1 1.7 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 RNase_PH PF01138.21 EKX74048.1 - 5.5e-05 23.7 0.3 0.0001 22.8 0.3 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Proteasome PF00227.26 EKX74049.1 - 2.3e-48 164.2 0.2 2.9e-48 163.9 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 EKX74049.1 - 0.023 14.1 0.0 0.023 14.1 0.0 2.0 3 0 0 3 3 3 0 Proteasome beta subunits C terminal DUF1989 PF09347.10 EKX74049.1 - 0.098 12.3 0.1 0.16 11.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1989) zf-DNA_Pol PF08996.10 EKX74050.1 - 0.011 15.5 1.5 0.016 14.9 1.5 1.2 1 0 0 1 1 1 0 DNA Polymerase alpha zinc finger zf-RING_5 PF14634.6 EKX74050.1 - 0.015 15.2 9.1 0.015 15.2 9.1 1.8 2 0 0 2 2 2 0 zinc-RING finger domain zf-C2H2 PF00096.26 EKX74050.1 - 0.056 13.9 0.1 0.056 13.9 0.1 3.2 4 0 0 4 4 4 0 Zinc finger, C2H2 type FOXP-CC PF16159.5 EKX74050.1 - 0.064 13.9 0.0 0.26 11.9 0.0 1.9 2 0 0 2 2 2 0 FOXP coiled-coil domain Sigma70_r1_1 PF03979.14 EKX74050.1 - 0.092 12.8 0.0 0.24 11.5 0.0 1.8 1 1 0 1 1 1 0 Sigma-70 factor, region 1.1 zf-C2H2_4 PF13894.6 EKX74050.1 - 0.36 11.8 0.2 0.36 11.8 0.2 3.4 3 1 1 4 4 4 0 C2H2-type zinc finger zf-C3HC4_2 PF13923.6 EKX74050.1 - 1.1 9.2 8.3 2.3 8.1 8.3 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) BRCA-2_OB1 PF09103.10 EKX74051.1 - 0.00085 19.3 0.1 0.0043 17.0 0.1 2.2 1 1 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 FeoB_Cyto PF17910.1 EKX74051.1 - 0.13 12.8 0.3 1.4 9.5 0.0 2.5 2 0 0 2 2 2 0 FeoB cytosolic helical domain Rpr2 PF04032.16 EKX74056.1 - 1.4e-18 67.0 0.8 1.9e-18 66.5 0.8 1.2 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain Sec16_C PF12931.7 EKX74058.1 - 1.8e-05 24.6 0.0 0.00014 21.6 0.0 2.1 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 WD40 PF00400.32 EKX74058.1 - 0.007 17.2 7.4 0.059 14.3 0.1 4.8 4 0 0 4 4 4 1 WD domain, G-beta repeat IBN_N PF03810.19 EKX74059.1 - 0.036 14.0 0.4 0.036 14.0 0.4 2.7 3 0 0 3 3 3 0 Importin-beta N-terminal domain E1-E2_ATPase PF00122.20 EKX74061.1 - 4.5e-18 65.4 0.2 1.4e-17 63.8 0.2 1.9 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EKX74061.1 - 6.2e-12 46.3 0.0 1.7e-05 25.2 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EKX74061.1 - 0.0014 18.7 0.0 0.0034 17.4 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Ytp1 PF10355.9 EKX74061.1 - 0.02 14.1 1.4 0.033 13.4 0.2 1.9 2 1 0 2 2 2 0 Protein of unknown function (Ytp1) LisH_2 PF16045.5 EKX74061.1 - 0.99 8.5 3.5 2.3 7.3 0.1 2.8 2 0 0 2 2 2 0 LisH DEAD PF00270.29 EKX74062.1 - 9.6e-24 84.1 4.4 8.7e-23 81.0 0.3 2.2 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 EKX74062.1 - 3.1e-22 79.0 6.6 7.3e-22 77.8 0.4 3.0 3 1 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKX74062.1 - 3.5e-06 27.1 4.5 1.7e-05 24.9 0.0 2.5 1 1 0 2 2 2 1 Type III restriction enzyme, res subunit Fe-ADH PF00465.19 EKX74062.1 - 0.29 9.9 0.7 1.1 7.9 0.1 2.2 3 0 0 3 3 3 0 Iron-containing alcohol dehydrogenase Toprim PF01751.22 EKX74062.1 - 0.58 10.4 4.3 5.5 7.3 3.8 2.7 2 1 0 2 2 2 0 Toprim domain Ribosomal_L31e PF01198.19 EKX74063.1 - 1.2e-39 134.4 4.2 1.5e-39 134.1 4.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e Cnd1 PF12717.7 EKX74064.1 - 2.2e-06 27.8 2.4 0.00041 20.4 0.1 3.3 1 1 3 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EKX74064.1 - 5.5e-06 26.2 0.5 0.22 11.9 0.0 4.8 5 0 0 5 5 5 2 HEAT repeat Vac14_Fab1_bd PF12755.7 EKX74064.1 - 0.00018 22.0 1.9 0.85 10.3 0.1 3.8 1 1 3 4 4 4 3 Vacuolar 14 Fab1-binding region Pkinase PF00069.25 EKX74064.1 - 0.0007 19.0 0.0 0.0017 17.8 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain CLASP_N PF12348.8 EKX74064.1 - 0.0062 16.1 0.2 0.11 12.0 0.1 2.2 1 1 0 1 1 1 1 CLASP N terminal Cofilin_ADF PF00241.20 EKX74065.1 - 1.1e-11 44.6 0.0 1.4e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein RRM_1 PF00076.22 EKX74066.1 - 7.6e-21 73.7 0.0 1.1e-20 73.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EKX74066.1 - 0.0002 20.9 0.0 0.00028 20.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EKX74066.1 - 0.0048 16.7 0.0 0.011 15.6 0.0 1.5 1 1 0 1 1 1 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EKX74066.1 - 0.015 15.3 0.0 0.023 14.7 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Prefoldin PF02996.17 EKX74067.1 - 1.1e-21 76.9 0.1 1.4e-21 76.6 0.1 1.1 1 0 0 1 1 1 1 Prefoldin subunit KxDL PF10241.9 EKX74067.1 - 0.0047 17.2 0.3 0.072 13.4 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein BLOC1_2 PF10046.9 EKX74067.1 - 0.056 13.8 1.3 1.9 8.8 0.2 2.4 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Prefoldin_2 PF01920.20 EKX74067.1 - 0.061 13.3 0.3 1.1 9.2 0.0 2.2 2 0 0 2 2 2 0 Prefoldin subunit DUF4448 PF14610.6 EKX74069.1 - 0.01 15.6 0.2 0.055 13.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) TMEM154 PF15102.6 EKX74069.1 - 0.016 15.1 0.0 0.029 14.3 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family Orf78 PF06024.12 EKX74069.1 - 0.016 15.5 0.0 0.035 14.4 0.0 1.6 1 1 0 1 1 1 0 Orf78 (ac78) DUF4825 PF16107.5 EKX74069.1 - 0.058 13.5 0.3 0.13 12.4 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4825) p25-alpha PF05517.12 EKX74071.1 - 9.2e-18 64.9 0.1 1e-17 64.7 0.1 1.0 1 0 0 1 1 1 1 p25-alpha DUF4250 PF14056.6 EKX74071.1 - 0.034 14.1 0.6 0.16 12.0 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4250) OSCP PF00213.18 EKX74072.1 - 1.7e-42 145.4 0.1 2e-42 145.2 0.1 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit Myb_DNA-binding PF00249.31 EKX74073.1 - 0.067 13.4 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain UIM PF02809.20 EKX74073.1 - 0.082 12.9 1.0 0.2 11.7 1.0 1.7 1 0 0 1 1 1 0 Ubiquitin interaction motif TRAPPC-Trs85 PF12739.7 EKX74075.1 - 7.1e-13 48.3 3.1 7.2e-13 48.3 1.7 1.8 2 1 0 2 2 2 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit HSP90 PF00183.18 EKX74076.1 - 5.5e-143 477.6 22.7 2.9e-141 471.9 18.1 3.6 3 1 1 4 4 4 2 Hsp90 protein HATPase_c_3 PF13589.6 EKX74076.1 - 2.5e-11 43.5 0.1 1.1e-10 41.5 0.1 2.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EKX74076.1 - 3.1e-09 37.3 0.3 8.8e-09 35.9 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DB_JBP1 PF18526.1 EKX74076.1 - 0.041 13.8 1.1 0.17 11.9 0.4 2.3 2 0 0 2 2 2 0 Thymine dioxygenase JBP1 DNA-binding domain AP2 PF00847.20 EKX74077.1 - 1.4e-12 47.7 0.2 2.6e-12 46.8 0.2 1.5 1 0 0 1 1 1 1 AP2 domain ACDC PF14733.6 EKX74077.1 - 5e-12 46.0 1.0 8.8e-12 45.2 1.0 1.4 1 0 0 1 1 1 1 AP2-coincident C-terminal Fumble PF03630.14 EKX74078.1 - 2.7e-23 82.7 0.0 4.7e-23 81.9 0.0 1.3 1 0 0 1 1 1 1 Fumble SNF2_N PF00176.23 EKX74079.1 - 1.5e-68 231.1 0.1 3.4e-68 229.9 0.1 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 EKX74079.1 - 7.6e-26 90.4 1.3 7.6e-26 90.4 1.3 2.3 2 0 0 2 2 2 1 SLIDE Helicase_C PF00271.31 EKX74079.1 - 2.1e-20 73.1 0.2 1.6e-19 70.3 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKX74079.1 - 1e-12 48.4 0.1 4.4e-12 46.3 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EKX74079.1 - 1e-05 25.4 0.0 5.6e-05 23.0 0.0 2.4 2 1 0 2 2 2 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EKX74079.1 - 0.00023 20.9 0.0 0.0027 17.4 0.0 2.5 2 0 0 2 2 2 1 SWI2/SNF2 ATPase AAA_14 PF13173.6 EKX74079.1 - 0.0035 17.4 0.1 0.018 15.1 0.1 2.2 1 0 0 1 1 1 1 AAA domain Myb_DNA-binding PF00249.31 EKX74079.1 - 0.011 15.9 0.2 0.12 12.6 0.0 2.8 3 0 0 3 3 3 0 Myb-like DNA-binding domain SRR1 PF07985.12 EKX74080.1 - 3.9e-05 23.6 0.0 8.5e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 SRR1 AAA PF00004.29 EKX74081.1 - 8.4e-96 317.5 0.0 8.5e-47 158.9 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EKX74081.1 - 7.3e-21 73.7 2.4 8.4e-11 41.5 0.8 3.0 2 1 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 EKX74081.1 - 9.2e-21 73.8 0.1 2.7e-20 72.3 0.1 1.9 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_16 PF13191.6 EKX74081.1 - 4.9e-13 49.8 0.1 0.00032 21.1 0.0 4.2 2 2 1 3 3 3 2 AAA ATPase domain RuvB_N PF05496.12 EKX74081.1 - 7.5e-13 48.5 0.0 2.7e-05 24.0 0.0 3.1 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EKX74081.1 - 5.7e-12 46.1 0.0 5.1e-06 26.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EKX74081.1 - 5.5e-11 42.8 0.0 2.4e-05 24.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EKX74081.1 - 2e-10 40.8 0.1 1.7e-05 24.8 0.0 3.2 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) CDC48_2 PF02933.17 EKX74081.1 - 2.8e-09 36.6 0.0 6e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 TIP49 PF06068.13 EKX74081.1 - 1.6e-08 34.2 0.0 0.00073 18.8 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 EKX74081.1 - 1.8e-08 34.7 0.2 0.028 14.7 0.0 3.8 2 2 1 3 3 3 2 AAA domain AAA_18 PF13238.6 EKX74081.1 - 1.3e-07 32.3 0.0 0.024 15.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 EKX74081.1 - 5e-07 29.8 0.0 0.02 14.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 EKX74081.1 - 7.4e-07 28.7 0.2 0.036 13.5 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EKX74081.1 - 1e-06 29.0 0.0 0.018 15.4 0.0 2.9 2 0 0 2 2 2 2 RNA helicase AAA_25 PF13481.6 EKX74081.1 - 4.8e-06 26.3 1.7 0.79 9.3 0.1 3.8 2 2 0 3 3 3 2 AAA domain ATPase_2 PF01637.18 EKX74081.1 - 1.1e-05 25.5 0.0 0.91 9.4 0.0 3.5 3 1 1 4 4 3 1 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 EKX74081.1 - 1.4e-05 24.9 0.0 0.17 11.6 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein Vps4_C PF09336.10 EKX74081.1 - 2.4e-05 24.3 0.5 0.0021 18.0 0.1 2.6 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain NACHT PF05729.12 EKX74081.1 - 4.6e-05 23.4 0.0 0.54 10.2 0.0 3.5 2 1 0 3 3 3 2 NACHT domain ABC_tran PF00005.27 EKX74081.1 - 4.7e-05 23.9 0.0 0.25 11.9 0.0 3.3 2 1 0 2 2 2 2 ABC transporter ATPase PF06745.13 EKX74081.1 - 7.6e-05 22.2 0.1 2.4 7.4 0.0 3.4 3 0 0 3 3 3 1 KaiC AAA_24 PF13479.6 EKX74081.1 - 8.7e-05 22.3 0.0 0.18 11.5 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EKX74081.1 - 9.1e-05 22.0 0.0 0.34 10.4 0.0 2.6 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_28 PF13521.6 EKX74081.1 - 9.5e-05 22.7 0.0 0.52 10.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.6 EKX74081.1 - 0.00013 22.4 0.0 0.39 11.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 EKX74081.1 - 0.00015 21.6 0.0 0.013 15.3 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase TsaE PF02367.17 EKX74081.1 - 0.0002 21.4 0.0 0.97 9.4 0.0 2.7 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 EKX74081.1 - 0.00032 19.9 0.0 0.53 9.3 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Zeta_toxin PF06414.12 EKX74081.1 - 0.00053 19.3 0.0 0.74 9.0 0.0 2.8 3 0 0 3 3 2 1 Zeta toxin NB-ARC PF00931.22 EKX74081.1 - 0.00057 19.2 0.0 0.89 8.7 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain Sigma54_activat PF00158.26 EKX74081.1 - 0.00057 19.6 0.0 1.2 8.9 0.0 3.3 2 1 0 2 2 2 1 Sigma-54 interaction domain DUF815 PF05673.13 EKX74081.1 - 0.0015 17.7 0.0 0.42 9.7 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Bac_DnaA PF00308.18 EKX74081.1 - 0.0023 17.8 0.0 1 9.1 0.0 2.4 2 0 0 2 2 2 1 Bacterial dnaA protein PhoH PF02562.16 EKX74081.1 - 0.0023 17.4 0.1 1.9 7.9 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein AAA_3 PF07726.11 EKX74081.1 - 0.0036 17.2 0.0 3.1 7.7 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) UFD1 PF03152.14 EKX74081.1 - 0.0048 16.4 0.0 0.009 15.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 DUF2075 PF09848.9 EKX74081.1 - 0.0058 15.9 0.0 0.66 9.2 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 EKX74081.1 - 0.0072 16.3 0.0 0.35 10.9 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Rad17 PF03215.15 EKX74081.1 - 0.0077 16.2 0.0 0.9 9.4 0.0 2.7 2 1 0 2 2 2 1 Rad17 P-loop domain Sigma54_activ_2 PF14532.6 EKX74081.1 - 0.0082 16.3 0.0 1.5 8.9 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_19 PF13245.6 EKX74081.1 - 0.013 15.8 0.1 6.1 7.2 0.1 3.0 2 1 1 3 3 2 0 AAA domain AAA_30 PF13604.6 EKX74081.1 - 0.033 13.9 0.1 7.7 6.2 0.1 2.5 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EKX74081.1 - 0.037 13.9 0.2 13 5.7 0.0 3.5 3 1 0 3 3 3 0 NTPase AAA_11 PF13086.6 EKX74081.1 - 0.037 13.8 0.0 11 5.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 EKX74081.1 - 0.045 13.5 0.1 7.2 6.3 0.0 2.6 2 0 0 2 2 2 0 Cytidylate kinase AAA_29 PF13555.6 EKX74081.1 - 0.05 13.4 0.0 5.8 6.7 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain Cytidylate_kin2 PF13189.6 EKX74081.1 - 0.063 13.4 0.0 15 5.6 0.0 2.6 2 0 0 2 2 2 0 Cytidylate kinase-like family SKI PF01202.22 EKX74081.1 - 0.082 13.0 0.1 17 5.5 0.0 2.4 2 0 0 2 2 2 0 Shikimate kinase SRPRB PF09439.10 EKX74081.1 - 0.094 12.1 0.0 36 3.7 0.0 3.5 3 1 0 3 3 3 0 Signal recognition particle receptor beta subunit Adeno_IVa2 PF02456.15 EKX74081.1 - 0.22 10.3 0.1 26 3.4 0.0 3.0 3 0 0 3 3 3 0 Adenovirus IVa2 protein AAA_21 PF13304.6 EKX74081.1 - 6.8 6.4 6.8 12 5.6 0.6 3.5 4 0 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system LSM PF01423.22 EKX74084.1 - 2.3e-12 46.4 0.0 3.9e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EKX74084.1 - 0.031 14.4 0.0 0.068 13.3 0.0 1.5 1 0 0 1 1 1 0 Ataxin 2 SM domain Bromodomain PF00439.25 EKX74085.1 - 0.011 15.8 0.0 0.028 14.5 0.0 1.8 1 0 0 1 1 1 0 Bromodomain Choline_kinase PF01633.20 EKX74086.1 - 5.9e-51 173.1 0.3 5.1e-50 170.0 0.0 2.1 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 EKX74086.1 - 4.2e-12 46.5 0.0 4.4e-11 43.2 0.0 2.3 2 1 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.20 EKX74086.1 - 0.082 12.2 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase Pkinase PF00069.25 EKX74086.1 - 0.085 12.2 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain Pkinase PF00069.25 EKX74087.1 - 1.1e-60 205.2 0.0 1.3e-60 205.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKX74087.1 - 6e-40 137.2 0.0 8.2e-40 136.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EKX74087.1 - 0.00013 21.1 0.6 0.00021 20.3 0.6 1.3 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EKX74087.1 - 0.0016 17.3 0.1 0.0018 17.1 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EKX74087.1 - 0.0045 16.4 0.0 0.0068 15.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EKX74087.1 - 0.068 12.5 0.2 0.12 11.7 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RRM_1 PF00076.22 EKX74089.1 - 6.5e-81 266.2 0.6 1.3e-20 73.0 0.1 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 EKX74089.1 - 4.6e-25 87.6 0.9 2.7e-24 85.1 0.1 2.5 3 0 0 3 3 3 1 Poly-adenylate binding protein, unique domain Nup35_RRM_2 PF14605.6 EKX74089.1 - 3.9e-06 26.7 1.1 0.1 12.6 0.0 4.3 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 EKX74089.1 - 3e-05 23.6 0.0 0.35 10.5 0.0 4.1 2 2 2 4 4 4 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EKX74089.1 - 0.00018 21.5 0.0 0.16 12.1 0.0 3.7 4 0 0 4 4 4 1 Limkain b1 RRM_3 PF08777.11 EKX74089.1 - 0.00023 21.2 0.1 2.1 8.4 0.0 3.7 4 0 0 4 4 4 1 RNA binding motif RRM_7 PF16367.5 EKX74089.1 - 0.00086 19.4 0.2 5.4 7.2 0.1 4.0 4 1 0 4 4 4 2 RNA recognition motif DUF4523 PF15023.6 EKX74089.1 - 0.0014 18.5 0.0 0.4 10.5 0.0 3.4 3 1 1 4 4 4 1 Protein of unknown function (DUF4523) DbpA PF03880.15 EKX74089.1 - 0.016 15.2 0.1 11 6.1 0.0 3.6 3 0 0 3 3 3 0 DbpA RNA binding domain Ish1 PF10281.9 EKX74089.1 - 0.082 13.2 0.0 0.22 11.8 0.0 1.7 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein RRS1 PF04939.12 EKX74090.1 - 3.4e-29 101.8 7.2 3.4e-29 101.8 7.2 1.5 2 0 0 2 2 2 1 Ribosome biogenesis regulatory protein (RRS1) GrpE PF01025.19 EKX74091.1 - 1.4e-40 138.7 18.0 1.1e-39 135.7 18.0 1.9 1 1 0 1 1 1 1 GrpE UPF0242 PF06785.11 EKX74091.1 - 0.0022 18.1 11.7 0.0035 17.5 11.7 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus POX PF07526.11 EKX74091.1 - 0.18 12.4 2.6 0.33 11.5 2.6 1.4 1 0 0 1 1 1 0 Associated with HOX Pinin_SDK_memA PF04696.13 EKX74091.1 - 0.32 11.1 11.5 0.46 10.6 11.5 1.2 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region DUF4407 PF14362.6 EKX74091.1 - 0.49 9.7 2.6 0.61 9.4 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PAP_central PF04928.17 EKX74091.1 - 0.63 9.0 7.1 21 4.0 7.1 2.1 1 1 0 1 1 1 0 Poly(A) polymerase central domain DUF1664 PF07889.12 EKX74091.1 - 0.94 9.5 5.5 2.3 8.3 5.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF1644 PF07800.12 EKX74091.1 - 1.1 9.3 4.7 6.2 6.9 4.7 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) DUF2730 PF10805.8 EKX74091.1 - 1.3 9.2 7.6 2.5 8.3 7.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) TPD52 PF04201.15 EKX74091.1 - 1.4 8.5 13.2 1.6 8.3 12.1 1.6 2 0 0 2 2 2 0 Tumour protein D52 family DUF5320 PF17253.2 EKX74091.1 - 3.1 8.9 5.7 6.9 7.8 5.7 1.8 1 1 0 1 1 1 0 Family of unknown function (DUF5320) LSM PF01423.22 EKX74093.1 - 1.3e-15 56.8 2.5 1.7e-15 56.5 2.5 1.1 1 0 0 1 1 1 1 LSM domain BPL_C PF02237.17 EKX74093.1 - 0.0028 17.5 0.4 0.0069 16.3 0.2 1.7 2 0 0 2 2 2 1 Biotin protein ligase C terminal domain SM-ATX PF14438.6 EKX74093.1 - 0.077 13.2 0.2 0.097 12.8 0.2 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain Tim44 PF04280.15 EKX74094.1 - 2e-31 109.1 0.0 4.3e-31 108.0 0.0 1.6 1 0 0 1 1 1 1 Tim44-like domain DivIVA PF05103.13 EKX74094.1 - 2.7 8.1 9.5 1 9.4 0.7 2.6 2 1 0 2 2 2 0 DivIVA protein Tim17 PF02466.19 EKX74095.1 - 1.6e-25 89.6 7.4 2.4e-25 89.1 7.4 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family MMS19_N PF14500.6 EKX74096.1 - 1e-27 97.4 4.3 2.9e-27 95.9 4.3 1.8 1 0 0 1 1 1 1 Dos2-interacting transcription regulator of RNA-Pol-II PhyH PF05721.13 EKX74097.1 - 0.011 16.0 0.0 0.036 14.3 0.0 1.9 1 1 0 1 1 1 0 Phytanoyl-CoA dioxygenase (PhyH) FAINT PF04385.15 EKX74098.1 - 4e-13 49.2 9.1 0.0077 16.3 0.2 4.6 4 0 0 4 4 4 4 Domain of unknown function, DUF529 MOLO1 PF17175.4 EKX74100.1 - 6.1e-11 42.5 0.2 1e-10 41.8 0.2 1.3 1 0 0 1 1 1 1 Modulator of levamisole receptor-1 Transket_pyr PF02779.24 EKX74102.1 - 2.6e-40 138.0 0.0 3.6e-40 137.5 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EKX74102.1 - 1.5e-36 125.0 0.1 2.3e-36 124.4 0.1 1.3 1 0 0 1 1 1 1 Transketolase, C-terminal domain PFOR_II PF17147.4 EKX74102.1 - 0.088 13.1 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II DUF498 PF04430.14 EKX74102.1 - 0.13 12.3 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF498/DUF598) tRNA-synt_2b PF00587.25 EKX74103.1 - 1e-32 113.6 0.0 4.6e-31 108.2 0.0 2.6 2 1 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EKX74103.1 - 6.6e-19 67.9 0.9 1.2e-18 67.1 0.1 1.9 2 0 0 2 2 2 1 Anticodon binding domain tRNA_SAD PF07973.14 EKX74103.1 - 9e-09 35.3 0.0 2e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Endonuc_Holl PF10107.9 EKX74103.1 - 0.084 12.7 0.0 0.53 10.1 0.0 2.2 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase ThiF PF00899.21 EKX74104.1 - 5.7e-28 97.9 0.0 8.9e-28 97.3 0.0 1.2 1 0 0 1 1 1 1 ThiF family ATG7_N PF16420.5 EKX74104.1 - 5.1e-12 46.1 0.0 8.7e-12 45.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus 2-Hacid_dh_C PF02826.19 EKX74104.1 - 0.00088 18.7 0.0 0.0088 15.4 0.0 2.1 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EKX74104.1 - 0.0026 17.8 0.0 0.53 10.3 0.0 2.4 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EKX74104.1 - 0.095 13.3 1.1 1 10.0 1.1 2.4 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 EKX74104.1 - 0.16 11.8 0.0 0.26 11.1 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PLU-1 PF08429.11 EKX74105.1 - 3.7e-34 118.4 6.0 3.1e-33 115.4 4.0 2.2 2 0 0 2 2 2 2 PLU-1-like protein EGF_3 PF12947.7 EKX74106.1 - 1.7e-07 31.3 27.9 5.6e-05 23.3 5.8 4.0 3 0 0 3 3 3 3 EGF domain FOG_N PF15888.5 EKX74106.1 - 0.0017 18.7 0.3 0.0043 17.4 0.3 1.8 1 0 0 1 1 1 1 Folded gastrulation N-terminus FXa_inhibition PF14670.6 EKX74106.1 - 0.0038 17.5 5.6 0.0038 17.5 5.6 4.3 3 1 1 4 4 4 1 Coagulation Factor Xa inhibitory site cEGF PF12662.7 EKX74106.1 - 0.013 15.4 26.9 0.22 11.5 5.7 4.7 4 0 0 4 4 4 0 Complement Clr-like EGF-like YrbL-PhoP_reg PF10707.9 EKX74106.1 - 0.31 10.5 0.9 0.42 10.1 0.0 1.5 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Plasmod_Pvs28 PF06247.11 EKX74106.1 - 1.4 9.3 21.7 3.2 8.1 4.3 3.6 3 0 0 3 3 3 0 Pvs28 EGF domain ABC_tran PF00005.27 EKX74107.1 - 1e-38 133.0 6.6 1.2e-18 68.0 0.0 4.5 3 2 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 EKX74107.1 - 1.3e-19 71.1 11.8 4.3e-06 26.8 0.9 4.5 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EKX74107.1 - 9.7e-10 38.2 7.8 4.6e-07 29.5 0.3 3.1 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EKX74107.1 - 2.1e-07 31.5 0.0 0.0069 16.8 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EKX74107.1 - 2.2e-07 30.5 0.1 0.012 15.3 0.1 3.2 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EKX74107.1 - 4.9e-07 29.8 0.2 0.014 15.3 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EKX74107.1 - 3e-06 27.6 1.3 1.2 9.4 0.0 4.2 4 0 0 4 4 3 2 AAA domain NACHT PF05729.12 EKX74107.1 - 3.2e-06 27.2 0.0 0.027 14.4 0.0 2.6 2 0 0 2 2 2 2 NACHT domain MMR_HSR1 PF01926.23 EKX74107.1 - 9.2e-06 25.7 0.7 0.024 14.7 0.1 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_24 PF13479.6 EKX74107.1 - 7.3e-05 22.6 2.5 0.0061 16.3 0.1 3.0 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EKX74107.1 - 8.6e-05 22.1 0.1 0.0097 15.4 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region Roc PF08477.13 EKX74107.1 - 0.00013 22.2 0.5 0.14 12.4 0.1 2.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 EKX74107.1 - 0.00016 20.9 0.0 0.12 11.5 0.0 2.5 2 0 0 2 2 2 2 NB-ARC domain AAA_18 PF13238.6 EKX74107.1 - 0.00038 21.0 0.2 0.83 10.2 0.0 2.9 2 0 0 2 2 2 2 AAA domain Septin PF00735.18 EKX74107.1 - 0.00096 18.5 0.6 0.89 8.8 0.1 2.6 2 0 0 2 2 2 2 Septin RNA_helicase PF00910.22 EKX74107.1 - 0.001 19.4 0.4 2 8.9 0.0 3.2 3 0 0 3 3 2 1 RNA helicase AAA_23 PF13476.6 EKX74107.1 - 0.0018 18.8 0.3 0.0018 18.8 0.3 3.8 3 1 1 4 4 3 2 AAA domain AAA PF00004.29 EKX74107.1 - 0.0025 18.2 0.0 4.4 7.7 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EKX74107.1 - 0.0042 17.4 0.0 0.53 10.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 EKX74107.1 - 0.0046 16.9 0.1 1.3 9.0 0.0 2.6 2 0 0 2 2 2 1 NTPase AAA_14 PF13173.6 EKX74107.1 - 0.0064 16.5 1.3 5.3 7.1 0.1 3.7 3 1 0 3 3 2 1 AAA domain FeoB_N PF02421.18 EKX74107.1 - 0.012 15.2 0.3 2.5 7.6 0.1 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B DUF815 PF05673.13 EKX74107.1 - 0.012 14.8 0.0 2 7.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 EKX74107.1 - 0.02 15.1 0.0 9.6 6.4 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EKX74107.1 - 0.025 14.5 0.2 15 5.6 0.0 3.0 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) MeaB PF03308.16 EKX74107.1 - 0.066 12.2 0.0 3.1 6.7 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran_Xtn PF12848.7 EKX74107.1 - 0.2 11.7 0.0 0.2 11.7 0.0 2.9 2 1 1 3 3 2 0 ABC transporter WSN PF02206.18 EKX74107.1 - 0.28 11.1 2.2 0.5 10.3 0.6 2.4 2 0 0 2 2 1 0 Domain of unknown function AAA_15 PF13175.6 EKX74107.1 - 0.46 10.1 40.1 0.49 10.0 2.3 4.9 1 1 2 3 3 2 0 AAA ATPase domain dNK PF01712.19 EKX74107.1 - 0.74 9.6 7.1 0.43 10.4 0.1 3.2 3 1 0 3 3 3 0 Deoxynucleoside kinase DUF87 PF01935.17 EKX74107.1 - 1.9 8.5 11.1 3.4 7.7 1.2 4.0 2 2 0 3 3 3 0 Helicase HerA, central domain Dynamin_N PF00350.23 EKX74107.1 - 5.8 6.9 7.4 16 5.5 0.5 3.8 3 0 0 3 3 3 0 Dynamin family EAP30 PF04157.16 EKX74109.1 - 2e-11 43.7 0.0 3.4e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 EAP30/Vps36 family RRM_1 PF00076.22 EKX74110.1 - 1.1e-11 44.4 0.0 1.6e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EKX74110.1 - 0.011 15.5 0.0 0.027 14.3 0.0 1.6 1 1 0 1 1 1 0 Occluded RNA-recognition motif DUF4523 PF15023.6 EKX74110.1 - 0.053 13.3 0.0 0.079 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) ADK PF00406.22 EKX74111.1 - 7.1e-29 100.8 0.0 9.4e-29 100.5 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EKX74111.1 - 1.8e-16 60.8 0.0 2.7e-16 60.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EKX74111.1 - 1e-09 39.0 0.0 2.5e-09 37.8 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EKX74111.1 - 3.5e-05 24.2 0.0 6.3e-05 23.4 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ADK_lid PF05191.14 EKX74111.1 - 0.00017 21.5 1.3 0.00039 20.3 1.3 1.7 1 1 0 1 1 1 1 Adenylate kinase, active site lid Cytidylate_kin PF02224.18 EKX74111.1 - 0.0003 20.6 0.0 0.00048 19.9 0.0 1.3 1 0 0 1 1 1 1 Cytidylate kinase AAA_33 PF13671.6 EKX74111.1 - 0.00049 20.3 0.0 0.00068 19.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EKX74111.1 - 0.00052 20.3 0.0 0.00082 19.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 EKX74111.1 - 0.00099 19.1 0.0 0.0021 18.0 0.0 1.7 1 1 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 EKX74111.1 - 0.0042 16.8 0.0 0.0088 15.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain SKI PF01202.22 EKX74111.1 - 0.0098 16.0 0.0 0.022 14.9 0.0 1.6 1 0 0 1 1 1 1 Shikimate kinase AAA_7 PF12775.7 EKX74111.1 - 0.013 15.1 0.2 0.35 10.3 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EKX74111.1 - 0.015 15.7 0.0 0.031 14.7 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_5 PF07728.14 EKX74111.1 - 0.041 13.9 0.0 0.087 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 EKX74111.1 - 0.047 14.2 0.0 0.086 13.4 0.0 1.6 1 1 0 1 1 1 0 ABC transporter AAA_25 PF13481.6 EKX74111.1 - 0.08 12.5 0.1 0.14 11.7 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EKX74111.1 - 0.091 12.5 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EKX74111.1 - 0.11 12.4 0.2 0.21 11.5 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase IstB_IS21 PF01695.17 EKX74111.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein TsaE PF02367.17 EKX74111.1 - 0.18 11.8 0.0 0.34 10.9 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Ribosomal_L29 PF00831.23 EKX74112.1 - 2.8e-17 62.4 1.6 2.8e-17 62.4 1.6 2.5 2 1 0 2 2 2 1 Ribosomal L29 protein TolA_bind_tri PF16331.5 EKX74112.1 - 0.039 14.0 2.4 0.094 12.8 0.2 2.2 2 0 0 2 2 2 0 TolA binding protein trimerisation Mlo PF03094.15 EKX74112.1 - 0.17 10.2 4.7 0.18 10.1 4.7 1.0 1 0 0 1 1 1 0 Mlo family Muted PF14942.6 EKX74112.1 - 0.31 11.4 10.3 0.92 9.8 10.3 1.7 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein DUF4407 PF14362.6 EKX74112.1 - 1.1 8.5 8.1 1.4 8.2 8.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2637 PF10935.8 EKX74113.1 - 1.7 8.5 7.7 0.96 9.3 2.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2637) PGK PF00162.19 EKX74114.1 - 2.6e-13 49.7 2.7 3.4e-13 49.3 2.7 1.1 1 0 0 1 1 1 1 Phosphoglycerate kinase ATPase-cat_bd PF12156.8 EKX74116.1 - 0.25 12.1 0.8 3.4 8.5 0.1 2.8 2 0 0 2 2 2 0 Putative metal-binding domain of cation transport ATPase FAINT PF04385.15 EKX74117.1 - 1.1e-07 31.9 21.6 0.00031 20.7 0.3 6.0 4 2 1 5 5 5 3 Domain of unknown function, DUF529 PRA-CH PF01502.18 EKX74119.1 - 0.18 11.7 0.4 2.7 7.9 0.0 3.2 2 0 0 2 2 2 0 Phosphoribosyl-AMP cyclohydrolase PGK PF00162.19 EKX74121.1 - 6.2e-148 492.8 0.0 6.9e-148 492.6 0.0 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase OGG_N PF07934.12 EKX74123.1 - 4.4e-19 68.8 0.1 7.4e-19 68.0 0.1 1.4 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 EKX74123.1 - 8.6e-15 55.1 0.0 1.3e-14 54.5 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EKX74123.1 - 7.1e-07 28.8 0.0 1.7e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 EKX74123.1 - 0.043 14.4 0.0 2.4 8.9 0.0 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix domain AP2 PF00847.20 EKX74124.1 - 3.6e-09 36.7 3.6 7.8e-09 35.6 3.6 1.6 1 0 0 1 1 1 1 AP2 domain ClpS PF02617.17 EKX74125.1 - 2.5e-15 56.0 0.0 5.3e-15 55.0 0.0 1.5 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS GATase_7 PF13537.6 EKX74125.1 - 0.11 12.5 0.0 0.44 10.5 0.0 1.8 2 0 0 2 2 2 0 Glutamine amidotransferase domain Peptidase_S26 PF10502.9 EKX74126.1 - 2.2e-05 24.2 0.0 0.0001 22.1 0.0 1.9 1 1 1 2 2 2 1 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.23 EKX74126.1 - 0.034 14.1 0.0 0.053 13.5 0.0 1.3 1 0 0 1 1 1 0 Peptidase S24-like DUF948 PF06103.11 EKX74127.1 - 0.0016 18.7 1.6 0.041 14.1 0.1 2.5 3 0 0 3 3 3 1 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 EKX74127.1 - 0.011 15.7 0.5 4.4 7.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF16 PF01519.16 EKX74127.1 - 0.014 15.9 0.1 1.6 9.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF16 Cor1 PF04803.12 EKX74127.1 - 0.019 15.2 0.9 0.85 9.8 0.0 2.1 2 0 0 2 2 2 0 Cor1/Xlr/Xmr conserved region PspB PF06667.12 EKX74127.1 - 0.02 14.9 0.5 0.044 13.8 0.5 1.6 1 0 0 1 1 1 0 Phage shock protein B CHD5 PF04420.14 EKX74127.1 - 0.034 14.0 0.5 0.2 11.5 0.0 1.9 2 0 0 2 2 2 0 CHD5-like protein DASH_Duo1 PF08651.10 EKX74127.1 - 0.069 12.9 6.1 2.6 7.9 0.2 2.4 2 0 0 2 2 2 0 DASH complex subunit Duo1 Fib_alpha PF08702.10 EKX74127.1 - 0.082 13.1 1.8 5.4 7.2 0.2 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family NPV_P10 PF05531.12 EKX74127.1 - 0.14 12.6 3.1 0.88 10.1 0.9 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein SlyX PF04102.12 EKX74127.1 - 1.4 9.6 5.1 0.7 10.6 0.3 2.6 2 1 0 2 2 2 0 SlyX DASH_Dad4 PF08650.10 EKX74127.1 - 2.3 8.3 6.0 7.6 6.6 0.2 2.6 2 1 1 3 3 3 0 DASH complex subunit Dad4 FAINT PF04385.15 EKX74128.1 - 6.9e-09 35.6 0.0 0.00028 20.9 0.0 2.8 3 0 0 3 3 3 2 Domain of unknown function, DUF529 IucA_IucC PF04183.12 EKX74128.1 - 0.13 11.8 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 IucA / IucC family DUF1134 PF06577.12 EKX74128.1 - 0.15 11.8 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1134) zf-C3HC4_3 PF13920.6 EKX74129.1 - 1.1e-09 38.0 9.9 3.1e-09 36.5 9.9 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Agenet PF05641.12 EKX74129.1 - 0.051 14.1 1.9 0.085 13.3 0.1 2.4 2 1 1 3 3 3 0 Agenet domain DNA_binding_2 PF13724.6 EKX74130.1 - 0.12 12.8 1.4 0.72 10.3 0.1 2.2 2 0 0 2 2 2 0 DNA-binding domain FAINT PF04385.15 EKX74132.1 - 1.7e-18 66.4 0.1 7e-08 32.4 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX74133.1 - 1.5e-24 85.8 17.9 6.6e-07 29.3 0.6 6.6 6 1 0 6 6 6 5 Domain of unknown function, DUF529 DUF5037 PF16440.5 EKX74133.1 - 0.027 14.0 0.0 1.9 8.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5037) Cu_bind_like PF02298.17 EKX74133.1 - 0.034 14.2 0.5 6.3 6.9 0.0 3.6 4 0 0 4 4 4 0 Plastocyanin-like domain RcnB PF11776.8 EKX74133.1 - 0.82 9.8 2.7 18 5.5 0.3 2.4 2 0 0 2 2 2 0 Nickel/cobalt transporter regulator FAINT PF04385.15 EKX74134.1 - 1.3e-08 34.8 0.7 0.00072 19.6 0.1 2.9 2 0 0 2 2 2 2 Domain of unknown function, DUF529 Fimbrial_PilY2 PF14481.6 EKX74134.1 - 0.21 11.3 0.0 0.41 10.3 0.0 1.4 1 0 0 1 1 1 0 Type 4 fimbrial biogenesis protein PilY2 Hydrolase_4 PF12146.8 EKX74135.1 - 6.1e-23 81.3 0.0 5.3e-22 78.3 0.0 2.4 2 1 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX74135.1 - 2.7e-09 37.0 6.2 0.084 12.9 0.0 5.3 5 0 0 5 5 5 3 Domain of unknown function, DUF529 Abhydrolase_6 PF12697.7 EKX74135.1 - 1.4e-06 29.0 0.0 3.5e-06 27.8 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EKX74135.1 - 0.00032 20.4 0.3 0.0034 17.1 0.2 2.7 2 1 0 2 2 2 1 alpha/beta hydrolase fold LIDHydrolase PF10230.9 EKX74135.1 - 0.0023 17.5 0.1 0.0048 16.5 0.1 1.4 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Peptidase_S9 PF00326.21 EKX74135.1 - 0.0083 15.6 0.0 8.5 5.8 0.0 3.1 3 0 0 3 3 3 2 Prolyl oligopeptidase family DUF676 PF05057.14 EKX74135.1 - 0.012 15.1 0.0 0.024 14.1 0.0 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_4 PF08386.10 EKX74135.1 - 0.017 15.3 0.0 0.04 14.0 0.0 1.6 1 0 0 1 1 1 0 TAP-like protein Abhydrolase_3 PF07859.13 EKX74135.1 - 0.021 14.7 0.0 0.045 13.6 0.0 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.13 EKX74135.1 - 0.046 13.4 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein DUF900 PF05990.12 EKX74135.1 - 0.11 11.9 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Hydrolase_4 PF12146.8 EKX74136.1 - 3e-18 66.0 0.0 1.3e-17 63.8 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX74136.1 - 4.8e-17 61.8 20.8 2.2e-07 30.8 2.3 4.4 4 0 0 4 4 4 3 Domain of unknown function, DUF529 Abhydrolase_1 PF00561.20 EKX74136.1 - 0.0012 18.6 0.0 0.0078 15.9 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 EKX74136.1 - 0.0012 18.7 0.0 0.0026 17.6 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Gly-zipper_Omp PF13488.6 EKX74137.1 - 0.008 16.2 3.5 0.011 15.7 3.5 1.3 1 0 0 1 1 1 1 Glycine zipper Romo1 PF10247.9 EKX74137.1 - 0.014 15.8 0.1 0.016 15.5 0.1 1.3 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 DUF456 PF04306.13 EKX74137.1 - 0.041 14.2 0.6 0.044 14.1 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF456) CD225 PF04505.12 EKX74137.1 - 0.15 12.2 0.2 0.67 10.1 0.2 2.1 1 1 0 1 1 1 0 Interferon-induced transmembrane protein Mid2 PF04478.12 EKX74137.1 - 8.2 6.2 7.5 9.7 6.0 7.5 1.3 1 1 0 1 1 1 0 Mid2 like cell wall stress sensor RNA_pol PF00940.19 EKX74139.1 - 5.5e-130 433.9 0.0 2.6e-129 431.7 0.0 2.0 1 1 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 EKX74139.1 - 3.4e-20 72.7 0.0 1.2e-18 67.7 0.0 2.5 1 1 0 1 1 1 1 DNA-directed RNA polymerase N-terminal VirK PF06903.12 EKX74139.1 - 0.081 13.0 0.0 0.35 11.0 0.0 2.0 2 0 0 2 2 2 0 VirK protein HlyD_D23 PF16576.5 EKX74139.1 - 0.11 11.7 0.1 1.2 8.3 0.0 2.1 2 0 0 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion DUF4519 PF15012.6 EKX74139.1 - 2.9 8.1 4.2 12 6.1 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) AGOG PF09171.10 EKX74140.1 - 0.051 12.9 2.8 0.14 11.4 2.8 1.7 1 0 0 1 1 1 0 N-glycosylase/DNA lyase ubiquitin PF00240.23 EKX74141.1 - 2.4e-08 33.6 0.1 3.5e-08 33.1 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family SPC25 PF06703.11 EKX74141.1 - 0.055 13.3 2.2 0.11 12.3 2.2 1.4 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) CitMHS PF03600.16 EKX74141.1 - 0.088 12.0 0.1 0.11 11.7 0.1 1.1 1 0 0 1 1 1 0 Citrate transporter Rep_fac_C PF08542.11 EKX74142.1 - 0.00019 21.7 0.0 0.00026 21.4 0.0 1.1 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EKX74144.1 - 1.2e-15 57.7 0.2 6.9e-15 55.2 0.2 2.0 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 EKX74144.1 - 7.9e-13 49.0 0.0 1.3e-12 48.2 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EKX74144.1 - 4.5e-08 33.1 0.0 7.1e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 EKX74144.1 - 1.6e-07 31.4 0.1 4.6e-07 29.9 0.0 1.7 2 1 0 2 2 2 1 Rad17 P-loop domain AAA_11 PF13086.6 EKX74144.1 - 2.5e-07 30.7 0.0 3.1e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EKX74144.1 - 2.1e-05 24.8 0.1 0.00015 22.0 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EKX74144.1 - 2.1e-05 24.9 0.1 6.6e-05 23.3 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EKX74144.1 - 6.8e-05 22.9 0.1 0.00015 21.8 0.1 1.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DEAD PF00270.29 EKX74144.1 - 0.0001 22.1 0.3 0.079 12.7 0.1 2.3 1 1 1 2 2 2 2 DEAD/DEAH box helicase AAA_24 PF13479.6 EKX74144.1 - 0.00018 21.3 0.0 0.0003 20.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EKX74144.1 - 0.0003 20.6 0.0 0.00058 19.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_assoc_2 PF16193.5 EKX74144.1 - 0.00096 19.5 0.0 0.0032 17.8 0.0 1.9 1 0 0 1 1 1 1 AAA C-terminal domain PhoH PF02562.16 EKX74144.1 - 0.0017 17.9 0.5 0.02 14.4 0.5 2.2 1 1 1 2 2 2 1 PhoH-like protein AAA_16 PF13191.6 EKX74144.1 - 0.0019 18.6 0.0 0.0095 16.3 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain ResIII PF04851.15 EKX74144.1 - 0.0024 17.9 0.2 0.1 12.6 0.0 2.1 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit DNA_pol3_delta PF06144.13 EKX74144.1 - 0.0042 16.9 0.1 0.0069 16.2 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit IstB_IS21 PF01695.17 EKX74144.1 - 0.0048 16.6 0.0 0.079 12.7 0.0 2.1 2 0 0 2 2 2 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 EKX74144.1 - 0.0062 15.9 0.1 0.086 12.2 0.0 2.4 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI DUF2075 PF09848.9 EKX74144.1 - 0.0071 15.6 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) TPR_6 PF13174.6 EKX74144.1 - 0.0076 16.8 0.7 2.5 8.9 0.0 3.6 4 0 0 4 4 3 1 Tetratricopeptide repeat TIP49 PF06068.13 EKX74144.1 - 0.0077 15.5 0.1 0.023 13.9 0.0 1.6 1 1 1 2 2 2 1 TIP49 P-loop domain SNF2_N PF00176.23 EKX74144.1 - 0.0084 14.9 0.1 0.015 14.0 0.1 1.3 1 1 0 1 1 1 1 SNF2 family N-terminal domain Hydin_ADK PF17213.3 EKX74144.1 - 0.0092 16.3 0.1 0.015 15.6 0.1 1.3 1 0 0 1 1 1 1 Hydin Adenylate kinase-like domain KTI12 PF08433.10 EKX74144.1 - 0.011 15.2 0.0 0.016 14.7 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_25 PF13481.6 EKX74144.1 - 0.014 15.0 0.1 0.045 13.3 0.1 1.8 1 1 0 1 1 1 0 AAA domain DnaB_C PF03796.15 EKX74144.1 - 0.045 13.1 0.3 0.11 11.8 0.3 1.5 1 1 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_33 PF13671.6 EKX74144.1 - 0.046 13.9 0.1 0.075 13.2 0.1 1.5 1 1 0 1 1 1 0 AAA domain PRONE PF03759.13 EKX74144.1 - 0.057 12.2 0.1 0.072 11.9 0.1 1.1 1 0 0 1 1 1 0 PRONE (Plant-specific Rop nucleotide exchanger) AAA_28 PF13521.6 EKX74144.1 - 0.075 13.3 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Zot PF05707.12 EKX74144.1 - 0.082 12.5 0.3 0.2 11.3 0.0 1.8 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) RNA_helicase PF00910.22 EKX74144.1 - 0.087 13.2 0.0 0.17 12.3 0.0 1.8 1 1 0 1 1 1 0 RNA helicase TniB PF05621.11 EKX74144.1 - 0.089 12.2 0.3 0.36 10.2 0.3 1.9 1 1 0 1 1 1 0 Bacterial TniB protein AAA_18 PF13238.6 EKX74144.1 - 0.14 12.7 0.0 0.28 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain FAINT PF04385.15 EKX74146.1 - 1.3e-06 28.3 1.4 2.4e-06 27.5 1.4 1.4 1 0 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 EKX74147.1 - 9.5e-25 86.5 0.0 6.5e-07 29.3 0.0 4.4 4 0 0 4 4 4 4 Domain of unknown function, DUF529 FAINT PF04385.15 EKX74149.1 - 6.1e-12 45.4 0.1 0.00017 21.6 0.1 2.6 2 0 0 2 2 2 2 Domain of unknown function, DUF529 FAINT PF04385.15 EKX74151.1 - 1.4e-17 63.5 16.7 6.7e-07 29.3 1.4 4.7 5 0 0 5 5 5 4 Domain of unknown function, DUF529 Ribosomal_S26e PF01283.19 EKX74154.1 - 1e-46 157.8 9.3 1.2e-46 157.6 9.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e SRP19 PF01922.17 EKX74154.1 - 0.014 16.3 0.1 0.026 15.5 0.1 1.5 1 1 0 1 1 1 0 SRP19 protein Eapp_C PF10238.9 EKX74155.1 - 2.5e-18 66.6 6.9 6.2e-17 62.1 6.9 2.0 1 1 0 1 1 1 1 E2F-associated phosphoprotein PH PF00169.29 EKX74156.1 - 0.042 14.4 0.0 0.28 11.7 0.0 2.3 1 1 0 1 1 1 0 PH domain Peptidase_C23 PF05379.11 EKX74156.1 - 0.055 13.6 0.0 0.28 11.3 0.0 2.2 2 0 0 2 2 2 0 Carlavirus endopeptidase LRR_5 PF13306.6 EKX74156.1 - 6 6.8 7.7 6.1 6.8 2.0 3.0 3 0 0 3 3 3 0 BspA type Leucine rich repeat region (6 copies) Pkinase PF00069.25 EKX74157.1 - 1.9e-79 266.8 0.0 3e-79 266.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKX74157.1 - 1.7e-41 142.3 0.0 2.3e-41 141.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 EKX74157.1 - 3.8e-26 88.6 11.5 1.6e-07 30.3 0.8 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EKX74157.1 - 5.4e-22 75.8 7.9 2.4e-05 23.9 0.2 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 EKX74157.1 - 1.8e-21 76.4 4.3 6.7e-11 42.5 0.2 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EKX74157.1 - 1.2e-19 69.9 7.9 6.3e-06 25.9 0.5 4.7 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 EKX74157.1 - 5.3e-19 66.8 14.6 3.7e-05 23.0 1.4 4.8 4 1 0 4 4 4 4 EF hand Kinase-like PF14531.6 EKX74157.1 - 6.5e-08 32.2 0.0 1.9e-07 30.7 0.0 1.7 2 0 0 2 2 2 1 Kinase-like SPARC_Ca_bdg PF10591.9 EKX74157.1 - 3.1e-07 30.7 1.5 0.018 15.4 0.0 3.3 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EKX74157.1 - 5.9e-07 29.4 4.3 0.00097 19.1 0.1 3.4 1 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand Kdo PF06293.14 EKX74157.1 - 6.4e-06 25.7 0.0 1.1e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EKX74157.1 - 8.4e-06 24.8 0.0 1.5e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EKX74157.1 - 2.5e-05 24.3 0.0 0.0067 16.4 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Dockerin_1 PF00404.18 EKX74157.1 - 0.012 15.8 2.6 15 5.9 0.6 4.5 4 1 0 4 4 4 0 Dockerin type I domain FTA2 PF13095.6 EKX74157.1 - 0.013 15.1 0.1 0.27 10.8 0.2 2.4 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DUF5580 PF17743.1 EKX74157.1 - 0.069 11.7 0.0 0.095 11.2 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5580) YrbL-PhoP_reg PF10707.9 EKX74157.1 - 0.083 12.4 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL EF-hand_11 PF08976.11 EKX74157.1 - 0.097 13.5 0.1 1.6 9.7 0.0 2.5 1 1 0 2 2 2 0 EF-hand domain RMI2 PF16100.5 EKX74158.1 - 0.00023 21.0 0.0 0.0004 20.2 0.0 1.4 1 0 0 1 1 1 1 RecQ-mediated genome instability protein 2 ANAPC4_WD40 PF12894.7 EKX74158.1 - 0.13 12.6 0.1 0.62 10.4 0.0 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain DUF4794 PF16042.5 EKX74159.1 - 0.054 14.5 1.6 0.054 14.5 1.6 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4794) WD40 PF00400.32 EKX74160.1 - 1e-07 32.5 2.3 2.1e-05 25.2 1.4 3.4 2 1 0 2 2 2 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKX74160.1 - 0.014 15.7 0.0 0.72 10.2 0.0 2.0 1 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EKX74160.1 - 0.13 12.1 0.1 1.6 8.5 0.1 2.4 1 1 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Topo-VIb_trans PF09239.11 EKX74161.1 - 0.13 12.1 0.0 2 8.2 0.0 2.2 2 0 0 2 2 2 0 Topoisomerase VI B subunit, transducer FAINT PF04385.15 EKX74163.1 - 3.3e-24 84.8 1.9 1.1e-06 28.6 0.0 5.4 5 0 0 5 5 5 5 Domain of unknown function, DUF529 LEM PF03020.15 EKX74164.1 - 0.094 12.3 0.0 0.24 11.0 0.0 1.7 1 0 0 1 1 1 0 LEM domain Tfb2 PF03849.14 EKX74165.1 - 1.8e-53 181.8 10.1 3e-35 121.9 4.8 2.8 1 1 1 2 2 2 2 Transcription factor Tfb2 Tfb2_C PF18307.1 EKX74165.1 - 0.00012 22.4 1.1 0.00032 21.1 1.1 1.7 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 EKX74165.1 - 0.00032 20.9 0.0 0.00083 19.5 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HIN PF02760.15 EKX74165.1 - 0.065 12.9 1.7 0.24 11.1 0.5 2.2 2 0 0 2 2 2 0 HIN-200/IF120x domain PH PF00169.29 EKX74166.1 - 0.0024 18.4 0.8 0.0042 17.6 0.8 1.4 1 0 0 1 1 1 1 PH domain Synaptobrevin PF00957.21 EKX74167.1 - 1.8e-06 27.6 1.8 3.3e-06 26.8 1.8 1.5 1 0 0 1 1 1 1 Synaptobrevin I_LWEQ PF01608.17 EKX74167.1 - 0.013 15.7 0.0 0.033 14.4 0.0 1.6 2 0 0 2 2 2 0 I/LWEQ domain LSM PF01423.22 EKX74168.1 - 4.3e-14 51.9 0.1 4.9e-14 51.8 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EKX74168.1 - 0.00063 19.8 0.0 0.00079 19.5 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain Pribosyltran_N PF13793.6 EKX74169.1 - 4.2e-39 133.1 0.0 1.1e-37 128.6 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EKX74169.1 - 2.9e-24 86.1 1.9 2.9e-24 86.1 1.9 1.6 2 0 0 2 2 2 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EKX74169.1 - 5.9e-12 45.4 0.4 1.9e-11 43.7 0.2 1.9 3 0 0 3 3 3 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EKX74169.1 - 0.0013 18.3 0.0 0.002 17.6 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Sterol_MT_C PF08498.10 EKX74169.1 - 0.052 13.9 0.1 0.13 12.6 0.1 1.6 1 0 0 1 1 1 0 Sterol methyltransferase C-terminal Rad10 PF03834.14 EKX74171.1 - 3.1e-32 111.0 0.9 4.5e-32 110.4 0.9 1.2 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.6 EKX74171.1 - 5e-06 27.0 0.0 1.2e-05 25.8 0.0 1.6 2 0 0 2 2 2 1 Helix-hairpin-helix domain TOPRIM_C PF16898.5 EKX74171.1 - 0.0042 17.4 0.0 0.0076 16.5 0.0 1.5 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM HHH_2 PF12826.7 EKX74171.1 - 0.0056 16.7 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif RNA_pol_A_CTD PF03118.15 EKX74171.1 - 0.013 15.3 0.1 0.027 14.2 0.1 1.6 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain Spc7 PF08317.11 EKX74172.1 - 0.002 17.1 2.9 0.0035 16.3 2.9 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein ANAPC15 PF15243.6 EKX74172.1 - 0.014 15.8 7.7 0.014 15.8 7.7 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 15 Golgin_A5 PF09787.9 EKX74172.1 - 0.022 14.2 6.6 0.031 13.7 6.6 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF745 PF05335.13 EKX74172.1 - 0.071 12.8 2.0 0.094 12.4 2.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) PPP4R2 PF09184.11 EKX74172.1 - 0.077 12.6 11.7 0.11 12.1 11.7 1.2 1 0 0 1 1 1 0 PPP4R2 DUF4446 PF14584.6 EKX74172.1 - 0.34 10.9 5.7 1.8 8.6 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) pRN1_helical PF13010.6 EKX74172.1 - 0.6 10.1 6.6 0.46 10.5 1.4 2.5 1 1 1 2 2 2 0 Primase helical domain KxDL PF10241.9 EKX74172.1 - 0.69 10.2 5.5 1.1 9.6 0.4 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein UPF0242 PF06785.11 EKX74172.1 - 0.72 9.9 7.9 0.98 9.5 7.9 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF724 PF05266.14 EKX74172.1 - 0.73 9.6 10.1 1.9 8.2 10.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF724) KLRAQ PF10205.9 EKX74172.1 - 1.6 9.1 11.9 1.8 8.8 4.6 2.3 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein GOLD_2 PF13897.6 EKX74172.1 - 6.9 7.2 9.6 53 4.3 0.0 2.2 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking Vps53_N PF04100.12 EKX74173.1 - 6.6e-60 203.1 5.4 6.6e-60 203.1 5.4 2.2 3 0 0 3 3 3 1 Vps53-like, N-terminal Importin_rep_3 PF18806.1 EKX74173.1 - 0.017 15.2 0.0 0.078 13.0 0.0 2.2 1 0 0 1 1 1 0 Importin 13 repeat FlxA PF14282.6 EKX74173.1 - 0.05 13.6 2.1 0.2 11.7 2.1 2.0 1 0 0 1 1 1 0 FlxA-like protein FapA PF03961.13 EKX74173.1 - 3.3 6.2 8.7 0.54 8.8 1.8 2.6 3 0 0 3 3 3 0 Flagellar Assembly Protein A DAD PF02109.16 EKX74174.1 - 0.00013 22.2 1.3 0.00015 22.0 1.3 1.1 1 0 0 1 1 1 1 DAD family Herpes_gE PF02480.16 EKX74174.1 - 0.0051 15.6 0.3 0.0051 15.6 0.3 1.2 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E DUF4173 PF13777.6 EKX74174.1 - 0.012 15.0 2.9 0.014 14.9 2.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4173) Col_cuticle_N PF01484.17 EKX74174.1 - 0.14 12.3 5.0 4.6 7.4 0.5 2.3 2 0 0 2 2 2 0 Nematode cuticle collagen N-terminal domain DUF5408 PF17402.2 EKX74174.1 - 0.96 9.4 0.0 0.96 9.4 0.0 2.6 3 0 0 3 3 3 0 Family of unknown function (DUF5408) tRNA-synt_2c PF01411.19 EKX74175.1 - 7.4e-193 642.0 0.0 1e-192 641.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EKX74175.1 - 7.3e-12 45.2 0.8 1.5e-11 44.2 0.8 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 EKX74175.1 - 0.0054 17.1 0.1 0.023 15.1 0.0 2.2 3 0 0 3 3 3 1 DHHA1 domain DUF1848 PF08902.11 EKX74175.1 - 0.08 12.7 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1848) NFACT-R_1 PF05670.13 EKX74177.1 - 1e-10 42.2 0.1 5.3e-09 36.7 0.0 2.5 2 0 0 2 2 2 1 NFACT protein RNA binding domain NFACT-R_2 PF18297.1 EKX74177.1 - 5.7e-07 29.7 0.0 1.4e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 NFACT protein RNA binding domain FbpA PF05833.11 EKX74177.1 - 6.5e-07 28.5 0.4 9.5e-07 27.9 0.4 1.3 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) CPSF_A PF03178.15 EKX74177.1 - 0.06 12.6 0.0 3.9 6.7 0.0 2.3 2 0 0 2 2 2 0 CPSF A subunit region BST2 PF16716.5 EKX74179.1 - 0.0089 16.6 6.9 0.0089 16.6 6.9 2.6 1 1 0 2 2 2 1 Bone marrow stromal antigen 2 FAM76 PF16046.5 EKX74179.1 - 4.4 6.6 19.0 7.4 5.8 19.0 1.4 1 0 0 1 1 1 0 FAM76 protein NIF PF03031.18 EKX74180.1 - 2.9e-33 114.9 0.3 4.8e-33 114.1 0.3 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Glyco_transf_4 PF13439.6 EKX74180.1 - 0.059 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase Family 4 DWNN PF08783.11 EKX74181.1 - 1.1e-08 35.2 0.0 3.3e-08 33.7 0.0 1.9 1 0 0 1 1 1 1 DWNN domain zf-RING_UBOX PF13445.6 EKX74181.1 - 0.034 14.2 12.5 0.85 9.7 9.2 2.4 2 0 0 2 2 2 0 RING-type zinc-finger DUF4139 PF13598.6 EKX74181.1 - 0.1 12.3 1.4 0.18 11.5 1.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4139) PseudoU_synth_2 PF00849.22 EKX74182.1 - 6e-28 97.9 0.1 8.8e-28 97.4 0.1 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase DBD_Tnp_Mut PF03108.15 EKX74182.1 - 0.04 13.9 0.1 0.13 12.3 0.1 1.9 1 0 0 1 1 1 0 MuDR family transposase Tcf25 PF04910.14 EKX74183.1 - 3.5e-32 111.8 4.7 4.5e-32 111.5 4.7 1.1 1 0 0 1 1 1 1 Transcriptional repressor TCF25 Actin PF00022.19 EKX74184.1 - 3.9e-49 167.3 0.0 4.9e-49 167.0 0.0 1.1 1 0 0 1 1 1 1 Actin Ppx-GppA PF02541.16 EKX74184.1 - 0.21 11.0 0.1 0.36 10.2 0.1 1.2 1 0 0 1 1 1 0 Ppx/GppA phosphatase family MtN3_slv PF03083.16 EKX74185.1 - 1.2e-24 86.2 17.7 2.1e-12 46.9 1.7 3.0 2 1 1 3 3 3 2 Sugar efflux transporter for intercellular exchange LAB_N PF07578.11 EKX74185.1 - 0.55 10.4 8.9 0.74 9.9 0.1 3.0 3 0 0 3 3 3 0 Lipid A Biosynthesis N-terminal domain MG4 PF17789.1 EKX74185.1 - 1.1 9.5 4.0 0.46 10.7 0.8 1.9 2 0 0 2 2 2 0 Macroglobulin domain MG4 SNAPc_SNAP43 PF09808.9 EKX74186.1 - 9.2e-08 32.2 0.6 1.1e-07 31.9 0.6 1.1 1 0 0 1 1 1 1 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 ATP_bind_1 PF03029.17 EKX74187.1 - 1.3e-66 224.9 0.0 1.5e-66 224.6 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 EKX74187.1 - 0.0032 17.7 0.0 0.011 16.0 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.6 EKX74187.1 - 0.0077 16.7 0.2 0.024 15.1 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EKX74187.1 - 0.012 15.6 0.0 0.03 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) MMR_HSR1 PF01926.23 EKX74187.1 - 0.021 14.9 0.0 0.1 12.7 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.6 EKX74187.1 - 0.028 15.0 0.0 0.093 13.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EKX74187.1 - 0.034 14.7 0.0 0.39 11.2 0.0 2.2 2 0 0 2 2 2 0 ABC transporter AAA_31 PF13614.6 EKX74187.1 - 0.04 13.8 0.0 0.23 11.3 0.0 2.1 1 1 0 1 1 1 0 AAA domain MeaB PF03308.16 EKX74187.1 - 0.057 12.4 0.0 0.11 11.5 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 EKX74187.1 - 0.086 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain ADK PF00406.22 EKX74187.1 - 0.11 12.6 0.0 0.28 11.3 0.0 1.7 1 0 0 1 1 1 0 Adenylate kinase Fer4_NifH PF00142.18 EKX74187.1 - 0.11 11.9 0.0 15 4.9 0.0 2.3 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_24 PF13479.6 EKX74187.1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EKX74187.1 - 0.13 12.0 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ThiF PF00899.21 EKX74189.1 - 8.8e-47 159.5 0.1 1.2e-46 159.1 0.1 1.2 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 EKX74189.1 - 0.00014 22.4 0.0 0.00085 19.8 0.0 2.3 2 1 0 2 2 2 1 Rhodanese-like domain Shikimate_DH PF01488.20 EKX74189.1 - 0.078 13.0 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase PglD_N PF17836.1 EKX74189.1 - 0.083 13.5 0.9 0.23 12.1 0.9 1.8 1 0 0 1 1 1 0 PglD N-terminal domain UDPG_MGDP_dh_N PF03721.14 EKX74189.1 - 0.15 11.6 0.4 0.25 10.9 0.4 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Herpes_U44 PF04533.13 EKX74190.1 - 0.0033 17.1 0.4 0.0059 16.2 0.4 1.4 1 0 0 1 1 1 1 Herpes virus U44 protein DnaJ PF00226.31 EKX74190.1 - 0.021 15.0 0.1 0.09 12.9 0.0 2.1 2 0 0 2 2 2 0 DnaJ domain Goodbye PF17109.5 EKX74190.1 - 0.49 10.9 2.5 7.4 7.1 0.2 2.6 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain HA2 PF04408.23 EKX74191.1 - 5.1e-19 68.6 0.0 1.3e-18 67.2 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EKX74191.1 - 5.4e-19 68.3 0.0 1.4e-18 67.1 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EKX74191.1 - 1.3e-12 48.1 0.0 3.4e-12 46.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EKX74191.1 - 2.8e-08 33.7 0.1 6.2e-08 32.6 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EKX74191.1 - 8.1e-07 29.4 0.1 2.3e-06 27.9 0.1 1.7 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EKX74191.1 - 7.6e-05 22.8 0.1 0.19 11.7 0.0 2.3 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EKX74191.1 - 0.00071 19.3 0.0 0.0012 18.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EKX74191.1 - 0.00092 19.6 0.1 0.0017 18.7 0.1 1.4 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 EKX74191.1 - 0.0027 17.7 0.1 0.0055 16.7 0.1 1.5 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_7 PF12775.7 EKX74191.1 - 0.0045 16.5 0.1 0.014 14.9 0.1 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region Cue1_U7BR PF18499.1 EKX74191.1 - 0.011 15.8 0.5 0.025 14.6 0.5 1.5 1 0 0 1 1 1 0 Ubc7p-binding region of Cue1 PhoH PF02562.16 EKX74191.1 - 0.021 14.3 0.1 0.045 13.2 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein SRP54 PF00448.22 EKX74191.1 - 0.024 14.3 0.7 0.1 12.2 0.7 1.9 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain T2SSE PF00437.20 EKX74191.1 - 0.032 13.3 0.0 0.07 12.2 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase PF06745.13 EKX74191.1 - 0.061 12.7 0.1 0.12 11.7 0.1 1.4 1 0 0 1 1 1 0 KaiC AAA_25 PF13481.6 EKX74191.1 - 0.067 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EKX74191.1 - 0.077 13.0 0.1 0.76 9.8 0.1 2.3 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EKX74191.1 - 0.079 12.7 0.0 0.53 10.0 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein ABC_tran PF00005.27 EKX74191.1 - 0.086 13.4 0.2 0.26 11.8 0.1 1.9 2 0 0 2 2 1 0 ABC transporter DUF2075 PF09848.9 EKX74191.1 - 0.18 11.0 0.0 0.27 10.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TsaE PF02367.17 EKX74191.1 - 0.19 11.7 0.1 0.5 10.4 0.1 1.7 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Phage_Mu_Gam PF07352.12 EKX74193.1 - 0.04 13.8 0.1 0.053 13.4 0.1 1.2 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein DUF573 PF04504.14 EKX74193.1 - 0.066 13.9 0.2 0.13 13.0 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function, DUF573 Atg8 PF02991.16 EKX74193.1 - 0.082 13.1 0.0 0.18 12.0 0.0 1.4 1 1 0 1 1 1 0 Autophagy protein Atg8 ubiquitin like DUF3519 PF12033.8 EKX74194.1 - 0.071 13.5 0.3 0.27 11.7 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3519) zf-C3HC4_3 PF13920.6 EKX74196.1 - 4.2e-13 48.9 5.2 9e-13 47.9 5.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EKX74196.1 - 1.1e-08 34.8 4.9 1.1e-08 34.8 4.9 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EKX74196.1 - 5.3e-06 26.7 7.1 5.3e-06 26.7 7.1 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EKX74196.1 - 2.1e-05 24.3 7.2 2.1e-05 24.3 7.2 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EKX74196.1 - 8.3e-05 22.3 7.3 8.3e-05 22.3 7.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EKX74196.1 - 0.00011 22.1 6.7 0.00011 22.1 6.7 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EKX74196.1 - 0.027 14.5 2.2 0.027 14.5 2.2 3.3 2 1 1 3 3 3 0 RING-type zinc-finger zf-RING_4 PF14570.6 EKX74196.1 - 8.3 6.3 9.8 2.2 8.2 6.3 1.9 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain RL10P_insert PF17777.1 EKX74197.1 - 5.4e-25 87.2 0.0 1e-24 86.3 0.0 1.5 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 EKX74197.1 - 6.4e-11 42.3 0.0 2.2e-10 40.6 0.0 1.8 1 1 0 1 1 1 1 Ribosomal protein L10 DUF2247 PF10004.9 EKX74197.1 - 0.091 12.5 0.4 0.16 11.8 0.4 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2247) tRNA-synt_1d PF00750.19 EKX74198.1 - 3.7e-51 174.1 0.5 4.3e-27 95.0 0.3 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (R) DALR_1 PF05746.15 EKX74198.1 - 4.6e-11 42.9 0.0 9.6e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 DALR anticodon binding domain CactinC_cactus PF09732.9 EKX74199.1 - 0.038 13.9 1.2 0.17 11.8 1.2 2.1 1 1 0 1 1 1 0 Cactus-binding C-terminus of cactin protein PhoU_div PF01865.16 EKX74200.1 - 0.0072 15.7 0.1 0.032 13.6 0.0 2.1 2 1 0 2 2 2 1 Protein of unknown function DUF47 UTP15_C PF09384.10 EKX74201.1 - 1.5e-25 89.6 0.2 2.3e-25 89.0 0.2 1.2 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 EKX74201.1 - 4.6e-19 68.4 16.2 1.9e-07 31.6 0.8 7.5 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKX74201.1 - 4.5e-07 30.1 0.0 0.78 10.1 0.0 5.1 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EKX74201.1 - 5.9e-05 22.2 0.0 0.13 11.2 0.0 2.6 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Utp12 PF04003.12 EKX74201.1 - 0.0027 18.0 1.8 0.008 16.5 0.9 2.2 2 0 0 2 2 2 1 Dip2/Utp12 Family Hira PF07569.11 EKX74201.1 - 0.1 12.3 0.4 13 5.5 0.0 2.8 3 0 0 3 3 3 0 TUP1-like enhancer of split Pkinase PF00069.25 EKX74202.1 - 1.1e-34 120.0 0.4 2e-34 119.1 0.4 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKX74202.1 - 1.4e-11 44.2 0.1 2.2e-11 43.5 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKX74202.1 - 0.0018 17.1 0.1 0.0028 16.5 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Bromodomain PF00439.25 EKX74203.1 - 2.6e-11 43.4 0.1 1.1e-10 41.4 0.1 2.2 1 0 0 1 1 1 1 Bromodomain ANAPC4_WD40 PF12894.7 EKX74203.1 - 2.4e-05 24.5 0.4 0.77 10.1 0.1 4.2 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain zf-HC5HC2H PF13771.6 EKX74203.1 - 0.00017 21.8 1.4 0.00017 21.8 1.4 2.6 2 0 0 2 2 2 1 PHD-like zinc-binding domain WD40 PF00400.32 EKX74203.1 - 0.0014 19.4 21.7 0.25 12.3 0.8 5.8 5 0 0 5 5 5 3 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 EKX74203.1 - 0.087 11.3 0.1 9 4.7 0.1 2.9 3 0 0 3 3 3 0 Cytochrome D1 heme domain AAR2 PF05282.11 EKX74204.1 - 1.2e-61 209.1 0.1 1.4e-61 208.9 0.1 1.0 1 0 0 1 1 1 1 AAR2 protein L_protein_N PF15518.6 EKX74204.1 - 0.098 12.5 0.7 0.32 10.9 0.3 2.0 2 0 0 2 2 2 0 L protein N-terminus RRM_1 PF00076.22 EKX74205.1 - 1.7e-21 75.8 0.7 4.6e-21 74.4 0.1 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EKX74205.1 - 9.1e-07 28.5 1.7 1.1e-06 28.3 0.9 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EKX74205.1 - 0.00031 20.6 0.0 0.00075 19.3 0.0 1.7 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_7 PF16367.5 EKX74205.1 - 0.0021 18.2 0.1 0.005 16.9 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif FlgI PF02119.16 EKX74205.1 - 0.0058 15.6 2.5 0.01 14.8 1.0 1.8 1 1 1 2 2 2 1 Flagellar P-ring protein IL2 PF00715.17 EKX74205.1 - 0.037 14.0 2.6 0.058 13.3 2.6 1.4 1 0 0 1 1 1 0 Interleukin 2 SseB_C PF14581.6 EKX74205.1 - 0.067 13.3 0.1 0.21 11.7 0.0 1.8 2 0 0 2 2 2 0 SseB protein C-terminal domain Pullulanase_N2 PF17967.1 EKX74205.1 - 0.13 13.2 0.0 0.2 12.5 0.0 1.3 1 0 0 1 1 1 0 Pullulanase N2 domain PHM7_cyt PF14703.6 EKX74205.1 - 0.32 11.2 11.2 0.64 10.2 0.1 3.1 1 1 2 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter WD40 PF00400.32 EKX74206.1 - 0.0035 18.1 4.7 38 5.4 0.2 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat Hira PF07569.11 EKX74206.1 - 0.13 12.0 0.0 0.33 10.7 0.0 1.6 1 0 0 1 1 1 0 TUP1-like enhancer of split Ipi1_N PF12333.8 EKX74207.1 - 0.029 14.9 0.1 0.04 14.5 0.1 1.2 1 0 0 1 1 1 0 Rix1 complex component involved in 60S ribosome maturation MCPVI PF02993.14 EKX74207.1 - 0.041 13.7 0.6 0.05 13.4 0.5 1.2 1 1 0 1 1 1 0 Minor capsid protein VI UCH PF00443.29 EKX74207.1 - 0.053 13.0 0.5 0.059 12.9 0.5 1.1 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Cyclin_C PF02984.19 EKX74207.1 - 0.18 11.9 0.2 0.44 10.6 0.1 1.7 1 1 0 1 1 1 0 Cyclin, C-terminal domain Myb_DNA-bind_6 PF13921.6 EKX74208.1 - 3.9e-10 39.8 0.2 9.9e-07 28.9 0.2 3.5 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EKX74208.1 - 2e-07 31.1 6.3 0.00012 22.1 0.4 4.2 5 0 0 5 5 5 3 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EKX74208.1 - 0.05 14.0 2.3 0.16 12.4 0.3 2.9 3 1 0 3 3 3 0 Myb/SANT-like DNA-binding domain RAP PF08373.10 EKX74209.1 - 6.3e-16 58.2 0.5 2e-15 56.6 0.5 2.0 1 0 0 1 1 1 1 RAP domain MTES_1575 PF18741.1 EKX74209.1 - 9.4e-05 22.5 0.2 0.045 13.9 0.1 3.1 2 1 0 2 2 2 1 REase_MTES_1575 DUF559 PF04480.12 EKX74209.1 - 0.0014 18.5 0.0 0.004 17.0 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF559) Surp PF01805.20 EKX74210.1 - 1.4e-37 127.4 1.1 2.2e-18 66.0 0.1 2.4 2 0 0 2 2 2 2 Surp module PRP21_like_P PF12230.8 EKX74210.1 - 2e-36 125.9 11.3 4.2e-35 121.6 11.3 2.3 1 1 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein MscS_TM PF12794.7 EKX74210.1 - 0.089 11.6 1.0 0.13 11.1 1.0 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 zf-WRNIP1_ubi PF18279.1 EKX74210.1 - 0.21 12.3 0.6 0.43 11.3 0.6 1.5 1 0 0 1 1 1 0 Werner helicase-interacting protein 1 ubiquitin-binding domain EAV_GP5 PF15981.5 EKX74211.1 - 0.014 15.8 0.1 0.077 13.4 0.0 2.3 2 1 0 2 2 2 0 Envelope glycoprotein GP 5 of equine arteritis virus Collagen PF01391.18 EKX74212.1 - 0.0026 17.5 9.1 0.0026 17.5 9.1 1.9 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) Calc_CGRP_IAPP PF00214.19 EKX74212.1 - 0.092 13.1 0.0 0.26 11.7 0.0 1.7 1 0 0 1 1 1 0 Calcitonin / CGRP / IAPP family ABC_tran PF00005.27 EKX74214.1 - 1.3e-31 109.9 0.0 1.3e-17 64.6 0.0 2.7 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EKX74214.1 - 1.3e-06 28.5 0.8 0.021 14.6 0.1 2.9 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EKX74214.1 - 6.4e-06 25.8 1.7 0.097 12.4 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EKX74214.1 - 1.3e-05 25.1 0.2 0.015 15.3 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 EKX74214.1 - 7.5e-05 23.3 3.3 0.19 12.2 0.2 2.7 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EKX74214.1 - 0.00019 21.8 0.0 0.11 12.9 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 EKX74214.1 - 0.00045 20.0 0.1 0.32 10.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 EKX74214.1 - 0.00075 18.8 0.3 0.24 10.6 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin MMR_HSR1 PF01926.23 EKX74214.1 - 0.00087 19.4 0.1 0.075 13.1 0.1 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_18 PF13238.6 EKX74214.1 - 0.0022 18.5 0.2 3.7 8.1 0.0 2.8 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 EKX74214.1 - 0.0034 16.8 0.3 0.82 9.0 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family Dynamin_N PF00350.23 EKX74214.1 - 0.0042 17.2 1.2 0.87 9.6 0.0 2.9 3 0 0 3 3 3 1 Dynamin family SMC_N PF02463.19 EKX74214.1 - 0.0049 16.3 1.7 0.078 12.4 0.2 2.6 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain MeaB PF03308.16 EKX74214.1 - 0.0049 15.9 0.6 0.042 12.8 0.1 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB DnaB_C PF03796.15 EKX74214.1 - 0.009 15.4 0.1 0.37 10.1 0.0 2.2 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_15 PF13175.6 EKX74214.1 - 0.013 15.3 0.6 3.7 7.2 0.1 2.5 2 0 0 2 2 2 0 AAA ATPase domain DUF87 PF01935.17 EKX74214.1 - 0.018 15.2 6.1 0.16 12.0 0.2 2.7 3 0 0 3 3 2 0 Helicase HerA, central domain Fer4_NifH PF00142.18 EKX74214.1 - 0.027 13.9 0.2 7.7 5.9 0.0 2.3 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family NACHT PF05729.12 EKX74214.1 - 0.048 13.6 0.7 8.7 6.2 0.1 2.7 2 0 0 2 2 2 0 NACHT domain T2SSE PF00437.20 EKX74214.1 - 0.053 12.6 0.3 4.4 6.3 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_22 PF13401.6 EKX74214.1 - 0.061 13.6 0.2 5.8 7.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain Peptidase_C30 PF05409.13 EKX74214.1 - 0.075 12.3 0.0 0.16 11.2 0.0 1.5 1 0 0 1 1 1 0 Coronavirus endopeptidase C30 AAA_25 PF13481.6 EKX74214.1 - 0.11 12.1 0.1 3.4 7.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EKX74214.1 - 0.13 11.8 0.4 18 4.8 0.1 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region SbcCD_C PF13558.6 EKX74214.1 - 0.13 12.5 0.0 0.31 11.3 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit cobW PF02492.19 EKX74214.1 - 0.18 11.4 1.0 7.9 6.0 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 EKX74214.1 - 0.2 10.8 2.4 0.76 8.9 0.1 2.5 3 0 0 3 3 2 0 NB-ARC domain GAS PF13851.6 EKX74215.1 - 0.21 10.9 15.0 0.35 10.2 15.0 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Nipped-B_C PF12830.7 EKX74216.1 - 0.0004 20.4 0.1 0.0014 18.7 0.1 1.9 1 0 0 1 1 1 1 Sister chromatid cohesion C-terminus Ca_bind_SSO6904 PF18249.1 EKX74216.1 - 0.12 12.7 2.8 2.7 8.4 0.3 3.5 2 0 0 2 2 2 0 Calcium binding protein SSO6904 Rad60-SLD PF11976.8 EKX74217.1 - 2.2e-21 75.5 0.0 2.7e-21 75.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EKX74217.1 - 6.4e-11 41.9 0.1 7.4e-11 41.7 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin family CLP_protease PF00574.23 EKX74218.1 - 8.2e-63 211.6 0.1 9.9e-63 211.3 0.1 1.1 1 0 0 1 1 1 1 Clp protease Glyco_transf_20 PF00982.21 EKX74218.1 - 0.02 13.6 0.1 0.031 12.9 0.1 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 20 Ephrin_rec_like PF07699.13 EKX74219.1 - 3.3e-38 129.2 115.7 2.6e-08 33.5 3.0 11.5 10 1 1 11 11 11 10 Putative ephrin-receptor like RANK_CRD_2 PF18278.1 EKX74219.1 - 0.82 9.9 39.4 1.2 9.4 1.1 8.8 9 0 0 9 9 9 0 Receptor activator of the NF-KB cysteine-rich repeat domain 2 Ephrin_rec_like PF07699.13 EKX74220.1 - 1.9e-40 136.3 123.1 2.7e-07 30.3 10.7 11.4 10 1 1 11 11 11 10 Putative ephrin-receptor like DUF4618 PF15397.6 EKX74220.1 - 0.02 14.3 0.9 0.033 13.6 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) CENP-F_leu_zip PF10473.9 EKX74220.1 - 0.021 14.9 1.8 0.037 14.0 1.8 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Syntaxin_2 PF14523.6 EKX74220.1 - 0.092 13.1 0.1 0.22 11.9 0.1 1.6 1 0 0 1 1 1 0 Syntaxin-like protein Nsp1_C PF05064.13 EKX74220.1 - 0.2 11.4 1.0 0.43 10.4 1.0 1.4 1 0 0 1 1 1 0 Nsp1-like C-terminal region DivIC PF04977.15 EKX74220.1 - 0.33 10.8 1.6 0.87 9.4 1.6 1.7 1 0 0 1 1 1 0 Septum formation initiator AAA_23 PF13476.6 EKX74220.1 - 0.65 10.5 6.1 2 8.9 6.1 1.8 1 1 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 EKX74221.1 - 3.2e-50 170.4 0.8 5.1e-50 169.7 0.8 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 EKX74221.1 - 2e-34 117.9 0.1 4.3e-34 116.9 0.1 1.6 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 EKX74221.1 - 6.7e-22 77.3 0.0 1.9e-21 75.9 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EKX74221.1 - 1.9e-09 37.8 0.9 5.2e-09 36.4 0.9 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EKX74221.1 - 6.4e-07 29.5 0.1 1.4e-06 28.3 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 EKX74221.1 - 8.7e-06 25.7 0.0 2.3e-05 24.4 0.0 1.7 1 1 0 1 1 1 1 Elongation Factor G, domain II Ras PF00071.22 EKX74221.1 - 1.6e-05 24.6 0.1 3.8e-05 23.4 0.1 1.6 1 1 0 1 1 1 1 Ras family PduV-EutP PF10662.9 EKX74221.1 - 0.00023 20.9 0.6 0.0011 18.7 0.9 2.0 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation RF3_C PF16658.5 EKX74221.1 - 0.0058 16.5 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain Roc PF08477.13 EKX74221.1 - 0.011 16.0 0.6 0.12 12.6 0.0 2.7 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Cpn10 PF00166.21 EKX74221.1 - 0.012 15.6 0.1 0.033 14.2 0.1 1.7 1 0 0 1 1 1 0 Chaperonin 10 Kd subunit Septin PF00735.18 EKX74221.1 - 0.065 12.5 0.3 0.39 9.9 0.0 2.0 2 0 0 2 2 2 0 Septin MMR_HSR1_Xtn PF16897.5 EKX74221.1 - 0.12 12.4 0.1 0.28 11.2 0.1 1.6 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Porin_3 PF01459.22 EKX74222.1 - 8.5e-25 87.7 0.2 2.9e-24 86.0 0.2 1.7 1 1 0 1 1 1 1 Eukaryotic porin Patatin PF01734.22 EKX74224.1 - 3.2e-08 34.0 0.1 1.2e-07 32.1 0.0 2.0 2 1 0 2 2 2 1 Patatin-like phospholipase Phage_Coat_A PF05357.13 EKX74224.1 - 0.00018 21.2 1.4 0.00025 20.8 0.3 1.8 2 0 0 2 2 2 1 Phage Coat Protein A Myc_target_1 PF15179.6 EKX74224.1 - 0.017 15.1 1.7 0.029 14.3 1.7 1.3 1 0 0 1 1 1 0 Myc target protein 1 Aconitase PF00330.20 EKX74225.1 - 1e-172 575.3 0.0 1.3e-172 574.9 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EKX74225.1 - 4.1e-42 143.6 0.0 7.6e-42 142.7 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Ribosomal_L2_C PF03947.18 EKX74226.1 - 6.7e-45 152.4 1.4 6.7e-45 152.4 1.4 1.7 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EKX74226.1 - 1.7e-18 66.3 0.3 4.6e-18 64.9 0.3 1.8 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain RNase_PH PF01138.21 EKX74227.1 - 4e-17 62.9 0.0 5e-17 62.6 0.0 1.1 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 GCP_C_terminal PF04130.13 EKX74228.1 - 4.5e-09 36.2 0.3 8.1e-09 35.4 0.3 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal Yos1 PF08571.10 EKX74228.1 - 7e-06 26.2 0.6 2.3e-05 24.6 0.1 2.2 2 0 0 2 2 2 1 Yos1-like tRNA-synt_1c PF00749.21 EKX74229.1 - 9e-104 346.7 0.1 1.3e-103 346.2 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EKX74229.1 - 8.4e-34 116.9 0.0 4.1e-33 114.7 0.0 2.2 3 0 0 3 3 3 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C PF00043.25 EKX74229.1 - 1e-08 35.2 0.0 3.1e-08 33.7 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EKX74229.1 - 9.3e-08 32.2 0.0 3.3e-07 30.4 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EKX74229.1 - 0.0013 18.7 0.0 0.0027 17.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Ribonuc_P_40 PF08584.11 EKX74231.1 - 9.9e-05 21.7 0.4 0.00014 21.2 0.4 1.5 1 1 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit EMA PF02488.15 EKX74232.1 - 1.4e-31 110.1 10.3 1.6e-31 109.8 10.3 1.1 1 0 0 1 1 1 1 Merozoite Antigen Peptidase_C97 PF05903.14 EKX74233.1 - 1.2e-32 112.8 0.5 2e-32 112.1 0.2 1.5 2 0 0 2 2 2 1 PPPDE putative peptidase domain LRAT PF04970.13 EKX74233.1 - 0.012 15.9 0.1 0.063 13.6 0.0 2.0 2 0 0 2 2 2 0 Lecithin retinol acyltransferase RRM_1 PF00076.22 EKX74234.1 - 1.4e-28 98.5 0.2 1.7e-14 53.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EKX74234.1 - 0.00011 21.8 0.0 0.015 14.9 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EKX74234.1 - 0.00017 21.4 0.0 0.069 13.0 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_7 PF16367.5 EKX74234.1 - 0.014 15.5 0.0 0.026 14.6 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif Nup35_RRM_2 PF14605.6 EKX74234.1 - 0.017 15.1 0.0 0.033 14.2 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif LUC7 PF03194.15 EKX74235.1 - 0.0091 15.7 0.8 0.015 15.0 0.8 1.3 1 0 0 1 1 1 1 LUC7 N_terminus CREPT PF16566.5 EKX74235.1 - 0.0096 16.1 0.2 0.018 15.2 0.2 1.5 1 0 0 1 1 1 1 Cell-cycle alteration and expression-elevated protein in tumour Mito_carr PF00153.27 EKX74237.1 - 6.2e-26 90.2 4.9 1.8e-11 43.8 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein SRP_SPB PF02978.19 EKX74238.1 - 0.11 13.2 0.0 0.19 12.4 0.0 1.4 1 0 0 1 1 1 0 Signal peptide binding domain tRNA-synt_1g PF09334.11 EKX74239.1 - 1.8e-68 231.1 0.1 7.9e-34 117.0 0.0 2.2 1 1 1 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EKX74239.1 - 2.6e-19 69.0 1.4 6.3e-10 37.9 0.1 4.0 2 1 0 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EKX74239.1 - 3.3e-09 36.5 0.0 5.1e-05 22.8 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 EKX74239.1 - 0.023 13.6 0.3 2.4 7.0 0.0 3.0 3 0 0 3 3 3 0 tRNA synthetases class I (K) UTP25 PF06862.12 EKX74240.1 - 6.9e-125 417.5 1.1 8.3e-125 417.2 1.1 1.1 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 zf-RING_2 PF13639.6 EKX74241.1 - 1.7e-12 47.4 6.3 1.7e-12 47.4 6.3 2.3 2 1 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 EKX74241.1 - 1.5e-08 34.7 8.5 1.5e-08 34.7 8.5 2.3 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EKX74241.1 - 1.3e-07 31.4 6.8 1.3e-07 31.4 6.8 2.5 2 2 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EKX74241.1 - 1.5e-07 31.0 2.1 4.4e-07 29.5 2.1 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 EKX74241.1 - 1.8e-06 27.7 5.1 1.8e-06 27.7 5.1 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EKX74241.1 - 4.9e-05 23.3 0.7 4.9e-05 23.3 0.7 2.4 2 1 0 2 2 2 1 RING-type zinc-finger zinc_ribbon_9 PF14369.6 EKX74241.1 - 0.00011 22.3 4.5 0.00011 22.3 1.0 2.5 2 0 0 2 2 2 1 zinc-ribbon zf-RING_5 PF14634.6 EKX74241.1 - 0.00019 21.3 4.5 0.00019 21.3 4.5 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EKX74241.1 - 0.0012 18.8 3.6 0.0035 17.4 3.6 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EKX74241.1 - 0.0032 17.3 2.2 0.0032 17.3 2.2 2.5 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 EKX74241.1 - 0.0035 17.5 5.2 0.0035 17.5 5.2 2.6 2 1 0 2 2 2 1 FANCL C-terminal domain Rad50_zn_hook PF04423.14 EKX74241.1 - 0.037 13.9 0.2 0.25 11.2 0.0 2.4 2 0 0 2 2 2 0 Rad50 zinc hook motif Zn-ribbon_8 PF09723.10 EKX74241.1 - 0.32 11.1 9.3 0.51 10.5 0.5 3.0 3 0 0 3 3 3 0 Zinc ribbon domain CTU2 PF10288.9 EKX74241.1 - 0.5 10.6 5.2 3 8.1 1.4 3.0 2 1 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 Baculo_IE-1 PF05290.11 EKX74241.1 - 0.97 9.4 4.0 0.22 11.5 0.3 1.7 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) zinc_ribbon_16 PF17034.5 EKX74241.1 - 0.99 9.6 5.0 1.9 8.7 2.3 2.3 1 1 1 2 2 2 0 Zinc-ribbon like family zf-CHY PF05495.12 EKX74241.1 - 2.8 8.5 8.1 1 9.9 0.2 2.5 2 1 0 2 2 2 0 CHY zinc finger Prok-RING_4 PF14447.6 EKX74241.1 - 4.7 7.1 13.6 0.1 12.4 4.1 2.7 2 2 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 EKX74241.1 - 5.4 6.9 9.7 0.43 10.4 3.2 2.3 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain MCM6_C PF18263.1 EKX74242.1 - 1.4e-08 34.9 0.1 1.5e-08 34.8 0.1 1.1 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain Cyclin_N PF00134.23 EKX74243.1 - 1e-07 31.7 0.1 8.8e-07 28.7 0.1 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EKX74243.1 - 0.0064 16.6 0.1 0.22 11.6 0.0 2.3 2 0 0 2 2 2 1 Cyclin, C-terminal domain TFIIB PF00382.19 EKX74243.1 - 0.11 12.6 1.3 0.48 10.5 0.1 2.1 2 0 0 2 2 2 0 Transcription factor TFIIB repeat NARP1 PF12569.8 EKX74244.1 - 3.4e-36 125.3 18.5 4.2e-26 91.9 9.5 4.0 3 1 0 3 3 3 2 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 EKX74244.1 - 3.3e-19 67.4 8.3 4.1e-05 23.4 0.1 7.4 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_1 PF00515.28 EKX74244.1 - 3.2e-15 55.2 6.6 1.7e-06 27.6 0.2 6.4 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 EKX74244.1 - 1.6e-08 34.7 0.5 0.58 10.5 0.0 5.5 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 EKX74244.1 - 1.9e-08 34.4 0.0 2.8 9.0 0.0 6.6 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 EKX74244.1 - 6.7e-08 32.1 10.9 0.026 14.7 0.3 6.8 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 EKX74244.1 - 2.3e-06 27.2 1.4 0.22 11.2 0.0 4.3 4 0 0 4 4 4 2 TPR repeat TPR_6 PF13174.6 EKX74244.1 - 3.1e-06 27.5 0.2 5.8 7.8 0.0 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EKX74244.1 - 1.1e-05 25.6 3.2 0.54 10.5 0.7 4.1 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EKX74244.1 - 1.9e-05 24.7 0.0 0.016 15.3 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 EKX74244.1 - 2.4e-05 23.7 0.0 0.36 10.0 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EKX74244.1 - 3.8e-05 23.4 0.2 0.13 12.3 0.0 5.6 7 0 0 7 7 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 EKX74244.1 - 0.00018 22.1 0.0 0.035 14.7 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EKX74244.1 - 0.0011 19.0 6.4 2.7 8.1 0.0 4.1 4 0 0 4 4 4 2 Fis1 C-terminal tetratricopeptide repeat TPR_17 PF13431.6 EKX74244.1 - 0.0035 17.6 0.0 15 6.2 0.2 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EKX74244.1 - 0.0038 17.7 0.1 93 3.6 0.0 5.0 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 EKX74244.1 - 0.03 14.2 0.2 3.7 7.5 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Prp18 PF02840.15 EKX74245.1 - 2.2e-53 180.2 0.3 2.2e-53 180.2 0.3 1.9 2 0 0 2 2 2 1 Prp18 domain PRP4 PF08799.11 EKX74245.1 - 6.7e-08 31.9 2.8 1.5e-07 30.8 2.8 1.6 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like DnaI_N PF07319.11 EKX74245.1 - 3.5 8.4 8.1 0.95 10.2 0.6 2.9 3 0 0 3 3 3 0 Primosomal protein DnaI N-terminus Ldh_1_N PF00056.23 EKX74246.1 - 1.2e-29 103.2 1.5 1.4e-29 103.0 0.4 1.6 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EKX74246.1 - 1.2e-23 83.8 0.0 2.2e-23 83.0 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.16 EKX74246.1 - 1.2e-06 28.2 0.1 4e-06 26.5 0.1 1.8 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase DUF1168 PF06658.12 EKX74247.1 - 4.3e-22 78.4 14.0 5.2e-22 78.1 14.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) Peptidase_S49_N PF08496.10 EKX74247.1 - 1.6 8.8 13.6 0.79 9.8 11.6 1.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF3987 PF13148.6 EKX74247.1 - 3.1 6.7 11.3 4 6.3 11.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) NAD_binding_1 PF00175.21 EKX74248.1 - 7.9e-18 65.1 0.0 1.2e-17 64.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EKX74248.1 - 0.00026 21.2 0.0 0.054 13.6 0.0 2.4 2 0 0 2 2 2 2 Ferric reductase NAD binding domain NPA PF16469.5 EKX74249.1 - 0.0087 16.6 1.6 1.3 9.7 0.2 2.5 2 0 0 2 2 2 2 Nematode polyprotein allergen ABA-1 RVT_1 PF00078.27 EKX74249.1 - 0.011 15.3 2.9 0.031 13.8 0.1 2.6 2 1 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) PBECR5 PF18814.1 EKX74249.1 - 0.08 12.9 1.2 0.75 9.7 0.0 2.2 1 1 1 2 2 2 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease5 EGF PF00008.27 EKX74250.1 - 0.0098 16.2 40.2 0.35 11.2 4.0 5.0 4 1 0 4 4 4 3 EGF-like domain FXa_inhibition PF14670.6 EKX74250.1 - 0.049 13.9 7.4 0.049 13.9 7.4 4.4 3 1 0 3 3 3 0 Coagulation Factor Xa inhibitory site hEGF PF12661.7 EKX74250.1 - 0.2 12.4 28.5 0.22 12.2 1.9 4.7 4 1 0 4 4 4 0 Human growth factor-like EGF Acetyltransf_1 PF00583.25 EKX74251.1 - 1.1e-10 41.7 0.0 1.3e-10 41.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EKX74251.1 - 1.6e-08 34.5 0.0 2.7e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EKX74251.1 - 4.3e-08 33.5 0.0 6.8e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EKX74251.1 - 0.0024 17.8 0.0 0.009 16.0 0.0 1.9 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EKX74251.1 - 0.0031 17.6 0.0 0.0059 16.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EKX74251.1 - 0.015 15.0 0.0 0.14 11.8 0.0 2.1 2 1 1 3 3 3 0 Acetyltransferase (GNAT) domain HECT PF00632.25 EKX74252.1 - 3.2e-46 158.2 1.3 8.7e-46 156.8 0.3 2.4 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) Ank_2 PF12796.7 EKX74252.1 - 3.2e-08 34.0 0.0 0.00015 22.3 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EKX74252.1 - 1.6e-07 31.7 0.4 0.49 11.0 0.0 4.4 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EKX74252.1 - 1.6e-06 28.3 0.0 0.0072 16.6 0.0 3.7 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EKX74252.1 - 2e-05 24.8 0.0 0.15 12.6 0.0 3.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 EKX74252.1 - 0.0084 16.5 0.2 11 7.0 0.0 4.8 3 1 0 3 3 3 1 Ankyrin repeat G3P_antiterm PF04309.12 EKX74252.1 - 0.15 11.5 0.5 7.4 5.9 0.1 2.7 3 0 0 3 3 3 0 Glycerol-3-phosphate responsive antiterminator ER PF01133.17 EKX74252.1 - 0.16 12.0 6.3 0.23 11.5 1.3 3.6 2 0 0 2 2 2 0 Enhancer of rudimentary XPG_N PF00752.17 EKX74252.1 - 1.1 9.8 3.4 2.3 8.7 1.2 2.7 2 0 0 2 2 2 0 XPG N-terminal domain UPF0086 PF01868.16 EKX74253.1 - 8.6e-21 73.7 0.0 1.3e-20 73.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function UPF0086 SANT_DAMP1_like PF16282.5 EKX74254.1 - 3.7e-23 81.5 1.6 3.7e-23 81.5 1.6 2.7 4 0 0 4 4 4 1 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_6 PF13921.6 EKX74254.1 - 0.013 15.7 1.8 0.26 11.5 0.3 3.0 2 0 0 2 2 2 0 Myb-like DNA-binding domain DUF1974 PF09317.11 EKX74254.1 - 0.038 13.6 0.8 0.078 12.5 0.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1974) FAA_hydro_N_2 PF18288.1 EKX74254.1 - 0.18 12.2 1.2 0.73 10.3 0.0 2.6 3 0 0 3 3 3 0 Fumarylacetoacetase N-terminal domain 2 CDP-OH_P_transf PF01066.21 EKX74255.1 - 1.8e-13 51.1 1.4 1.8e-13 51.1 1.4 2.1 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Pkinase PF00069.25 EKX74256.1 - 2.1e-33 115.8 0.0 1.4e-24 86.9 0.0 2.6 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EKX74256.1 - 1.7e-15 57.0 0.0 2.9e-11 43.2 0.0 3.1 2 1 0 2 2 2 2 Protein tyrosine kinase FTA2 PF13095.6 EKX74256.1 - 0.056 13.1 0.1 7.9 6.0 0.0 2.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 KNOX2 PF03791.13 EKX74256.1 - 0.16 11.5 0.0 0.35 10.4 0.0 1.6 1 0 0 1 1 1 0 KNOX2 domain SF1-HH PF16275.5 EKX74257.1 - 2.7e-30 105.0 0.1 2.7e-30 105.0 0.1 2.8 2 0 0 2 2 2 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.29 EKX74257.1 - 6.4e-08 32.3 1.1 6.9e-07 29.0 0.1 2.5 2 0 0 2 2 2 1 KH domain zf-CCHC PF00098.23 EKX74257.1 - 4.9e-06 26.4 9.8 0.028 14.5 0.1 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 EKX74257.1 - 0.0019 18.1 3.8 0.3 11.1 1.1 2.5 1 1 1 2 2 2 2 Zinc knuckle zf-RING_9 PF13901.6 EKX74257.1 - 0.0033 17.4 0.6 0.0033 17.4 0.6 2.2 1 1 1 2 2 2 1 Putative zinc-RING and/or ribbon zf-CCHC_4 PF14392.6 EKX74257.1 - 0.041 13.6 7.3 0.72 9.6 0.2 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.6 EKX74257.1 - 1.2 9.0 7.3 1.8 8.5 0.0 2.7 2 0 0 2 2 2 0 Zinc knuckle TORC_N PF12884.7 EKX74257.1 - 3.5 8.5 7.9 5.6 7.8 6.4 2.1 2 0 0 2 2 2 0 Transducer of regulated CREB activity, N terminus DnaJ_CXXCXGXG PF00684.19 EKX74257.1 - 3.5 8.1 9.2 0.075 13.4 1.9 2.0 2 0 0 2 2 2 0 DnaJ central domain SUV3_C PF12513.8 EKX74258.1 - 1.6e-11 44.0 0.1 4.1e-11 42.6 0.1 1.7 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 EKX74258.1 - 7.4e-11 42.4 0.1 2.1e-10 40.9 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain MFS_1 PF07690.16 EKX74261.1 - 2.3e-19 69.5 29.2 2.3e-19 69.5 29.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily GATase PF00117.28 EKX74261.1 - 2.2e-10 40.6 0.0 1.1e-09 38.4 0.0 2.0 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EKX74261.1 - 0.003 17.4 0.2 0.16 11.7 0.1 3.0 4 0 0 4 4 4 1 Peptidase C26 GATase_3 PF07685.14 EKX74261.1 - 0.031 13.9 0.0 0.052 13.1 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain Cadherin_C_2 PF16492.5 EKX74261.1 - 0.046 14.5 0.1 0.23 12.2 0.0 2.2 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal TSLP PF15216.6 EKX74261.1 - 0.072 13.4 0.7 0.17 12.2 0.7 1.5 1 0 0 1 1 1 0 Thymic stromal lymphopoietin DUF3007 PF11460.8 EKX74261.1 - 0.16 12.2 2.2 0.22 11.8 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3007) Helicase_C PF00271.31 EKX74263.1 - 9.4e-13 48.5 0.0 2.4e-09 37.5 0.0 3.9 2 1 0 3 3 3 2 Helicase conserved C-terminal domain GUCT PF08152.12 EKX74263.1 - 3.2e-06 27.3 0.0 7.9e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 GUCT (NUC152) domain STD1 PF17235.2 EKX74265.1 - 0.011 15.4 0.1 0.03 14.0 0.1 1.8 1 0 0 1 1 1 0 STD1/MTH1 RAP PF08373.10 EKX74265.1 - 0.032 14.3 0.2 0.032 14.3 0.2 2.6 2 0 0 2 2 2 0 RAP domain RNase_H2-Ydr279 PF09468.10 EKX74265.1 - 0.041 14.1 0.0 0.14 12.3 0.0 1.9 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) wHTH domain AAA PF00004.29 EKX74266.1 - 2e-83 277.4 0.0 4.4e-46 156.6 0.0 3.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EKX74266.1 - 2e-26 91.5 0.2 4.3e-12 45.6 0.1 2.7 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 EKX74266.1 - 2e-12 47.1 0.0 4.2e-05 23.4 0.0 3.0 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EKX74266.1 - 4.2e-11 43.5 1.5 0.00064 20.1 0.0 4.3 2 2 2 4 4 4 2 AAA ATPase domain AAA_5 PF07728.14 EKX74266.1 - 1.3e-10 41.5 0.1 0.0017 18.4 0.0 4.0 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EKX74266.1 - 4.1e-09 36.1 0.9 0.0019 17.5 0.0 3.0 3 0 0 3 3 3 2 TIP49 P-loop domain RNA_helicase PF00910.22 EKX74266.1 - 8.8e-09 35.7 0.1 0.0039 17.6 0.0 3.8 3 1 1 4 4 3 2 RNA helicase AAA_18 PF13238.6 EKX74266.1 - 1.7e-08 35.1 0.0 0.009 16.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 EKX74266.1 - 4.2e-08 33.1 0.0 0.0052 16.5 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_22 PF13401.6 EKX74266.1 - 5.2e-08 33.3 0.5 0.024 14.9 0.0 4.4 3 2 1 5 5 4 2 AAA domain AAA_2 PF07724.14 EKX74266.1 - 6.4e-08 32.9 0.0 0.00092 19.4 0.0 2.9 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) ABC_tran PF00005.27 EKX74266.1 - 1.2e-07 32.3 0.2 0.029 14.9 0.0 2.9 3 0 0 3 3 2 2 ABC transporter AAA_33 PF13671.6 EKX74266.1 - 3.6e-07 30.5 0.0 0.027 14.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 EKX74266.1 - 7.7e-07 28.7 0.5 0.019 14.4 0.0 2.7 3 0 0 3 3 2 2 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EKX74266.1 - 4.3e-06 27.1 0.2 0.2 11.9 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA_14 PF13173.6 EKX74266.1 - 1.1e-05 25.4 0.0 0.0022 18.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 EKX74266.1 - 1.2e-05 25.8 0.3 0.14 12.6 0.0 3.1 3 0 0 3 3 2 2 AAA domain ATPase_2 PF01637.18 EKX74266.1 - 2.3e-05 24.4 0.9 0.32 10.9 0.0 3.6 2 1 1 3 3 3 2 ATPase domain predominantly from Archaea Parvo_NS1 PF01057.17 EKX74266.1 - 2.9e-05 23.3 0.1 0.24 10.5 0.0 2.8 3 0 0 3 3 3 2 Parvovirus non-structural protein NS1 AAA_24 PF13479.6 EKX74266.1 - 3e-05 23.8 0.0 0.2 11.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EKX74266.1 - 3.4e-05 23.5 2.0 1.3 8.6 0.0 4.0 3 1 1 4 4 4 1 AAA domain AAA_3 PF07726.11 EKX74266.1 - 3.5e-05 23.7 0.0 0.25 11.2 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 EKX74266.1 - 4.1e-05 23.6 0.0 0.08 13.0 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 EKX74266.1 - 8e-05 21.9 0.0 0.34 10.0 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF815) Vps4_C PF09336.10 EKX74266.1 - 8.4e-05 22.5 0.6 0.015 15.3 0.1 2.7 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain Sigma54_activat PF00158.26 EKX74266.1 - 0.0001 22.0 0.0 0.55 9.9 0.0 3.9 4 0 0 4 4 4 1 Sigma-54 interaction domain Zeta_toxin PF06414.12 EKX74266.1 - 0.00012 21.5 0.1 0.48 9.7 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin NACHT PF05729.12 EKX74266.1 - 0.00026 20.9 0.1 0.48 10.3 0.0 2.7 3 0 0 3 3 2 2 NACHT domain AAA_7 PF12775.7 EKX74266.1 - 0.00058 19.4 0.0 0.78 9.2 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region NB-ARC PF00931.22 EKX74266.1 - 0.00087 18.5 0.0 0.14 11.3 0.0 2.5 2 1 0 2 2 2 1 NB-ARC domain Rad17 PF03215.15 EKX74266.1 - 0.001 19.0 0.1 0.53 10.2 0.0 3.0 3 0 0 3 3 2 1 Rad17 P-loop domain CPT PF07931.12 EKX74266.1 - 0.0029 17.5 0.0 0.66 9.8 0.0 2.5 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein AAA_29 PF13555.6 EKX74266.1 - 0.0031 17.2 0.1 0.23 11.2 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain SMC_N PF02463.19 EKX74266.1 - 0.0043 16.5 0.1 1.4 8.4 0.0 3.3 2 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain NTPase_1 PF03266.15 EKX74266.1 - 0.0077 16.2 0.0 1.5 8.7 0.0 3.0 2 1 0 2 2 2 1 NTPase Viral_helicase1 PF01443.18 EKX74266.1 - 0.011 15.5 0.0 3.5 7.3 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Nucleolin_bd PF16725.5 EKX74266.1 - 0.012 15.2 0.2 0.36 10.5 0.0 2.5 2 0 0 2 2 2 0 Nucleolin binding domain Cytidylate_kin PF02224.18 EKX74266.1 - 0.019 14.7 0.2 3 7.5 0.0 2.6 2 0 0 2 2 2 0 Cytidylate kinase T2SSE PF00437.20 EKX74266.1 - 0.021 13.9 0.3 10 5.1 0.0 2.9 3 0 0 3 3 3 0 Type II/IV secretion system protein ATPase PF06745.13 EKX74266.1 - 0.023 14.1 0.1 1.9 7.8 0.0 2.7 2 0 0 2 2 2 0 KaiC SKI PF01202.22 EKX74266.1 - 0.024 14.8 1.2 9.7 6.3 0.0 3.1 4 0 0 4 4 2 0 Shikimate kinase ATP-synt_ab PF00006.25 EKX74266.1 - 0.04 13.6 0.0 0.13 11.9 0.0 1.9 2 0 0 2 2 1 0 ATP synthase alpha/beta family, nucleotide-binding domain MMR_HSR1 PF01926.23 EKX74266.1 - 0.047 13.8 0.1 6.2 6.9 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_23 PF13476.6 EKX74266.1 - 0.047 14.2 2.9 5.3 7.5 0.0 3.2 3 0 0 3 3 3 0 AAA domain PduV-EutP PF10662.9 EKX74266.1 - 0.061 13.1 0.0 3 7.6 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation CobU PF02283.16 EKX74266.1 - 0.064 12.8 0.0 0.15 11.6 0.0 1.7 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase Bac_DnaA PF00308.18 EKX74266.1 - 0.071 12.9 0.0 1.6 8.5 0.0 2.7 2 0 0 2 2 2 0 Bacterial dnaA protein AAA_11 PF13086.6 EKX74266.1 - 0.072 12.9 2.2 11 5.8 0.0 3.2 3 0 0 3 3 3 0 AAA domain Sigma54_activ_2 PF14532.6 EKX74266.1 - 0.087 12.9 0.0 6.1 7.0 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_19 PF13245.6 EKX74266.1 - 0.1 12.9 0.2 15 5.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain DDHD PF02862.17 EKX74267.1 - 7.5e-36 124.4 1.0 7.9e-36 124.3 0.1 1.5 2 0 0 2 2 2 1 DDHD domain Lipase_2 PF01674.18 EKX74267.1 - 0.015 14.8 0.0 0.029 13.9 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 2) DUF676 PF05057.14 EKX74267.1 - 0.042 13.4 0.0 0.13 11.8 0.0 1.8 2 0 0 2 2 2 0 Putative serine esterase (DUF676) Sod_Fe_C PF02777.18 EKX74268.1 - 4.9e-38 129.4 1.8 8.7e-37 125.4 0.0 2.3 2 1 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EKX74268.1 - 1.3e-30 105.7 1.8 1.9e-30 105.1 0.3 1.9 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Urb2 PF10441.9 EKX74270.1 - 0.035 14.1 0.4 0.14 12.1 0.0 1.9 1 1 1 2 2 2 0 Urb2/Npa2 family RAP PF08373.10 EKX74271.1 - 1.3e-16 60.4 0.1 1.5e-16 60.2 0.1 1.1 1 0 0 1 1 1 1 RAP domain DnaJ PF00226.31 EKX74273.1 - 1.8e-20 72.8 0.7 5.1e-20 71.3 0.7 1.9 1 0 0 1 1 1 1 DnaJ domain DUF1977 PF09320.11 EKX74273.1 - 9.4e-07 29.1 3.0 9.4e-07 29.1 3.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1977) TPR_2 PF07719.17 EKX74273.1 - 0.015 15.4 0.0 0.048 13.8 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat Foie-gras_1 PF11817.8 EKX74273.1 - 0.028 14.0 0.2 0.081 12.5 0.0 1.8 2 0 0 2 2 2 0 Foie gras liver health family 1 ANAPC3 PF12895.7 EKX74273.1 - 0.031 14.5 1.5 0.052 13.8 0.5 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 YfiO PF13525.6 EKX74273.1 - 0.04 13.6 0.1 0.04 13.6 0.1 1.7 2 0 0 2 2 2 0 Outer membrane lipoprotein TPR_8 PF13181.6 EKX74273.1 - 0.11 12.7 0.1 0.57 10.5 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat CLPTM1 PF05602.12 EKX74275.1 - 6.7e-85 285.7 8.7 8.7e-85 285.3 8.7 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 EKX74275.1 - 6.4e-07 29.0 1.8 0.039 13.7 0.1 2.9 2 0 0 2 2 2 2 PQ loop repeat H_PPase PF03030.16 EKX74275.1 - 0.041 12.5 1.8 0.066 11.8 1.8 1.3 1 0 0 1 1 1 0 Inorganic H+ pyrophosphatase Peptidase_M18 PF02127.15 EKX74276.1 - 7.6e-123 410.5 0.0 8.7e-123 410.3 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 EKX74276.1 - 0.00064 18.8 0.0 0.056 12.5 0.0 2.3 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase Syja_N PF02383.18 EKX74277.1 - 3.5e-64 217.2 0.0 5.4e-64 216.5 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 EKX74277.1 - 1.2e-09 38.0 0.0 2.4e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Helicase_C PF00271.31 EKX74278.1 - 6.8e-18 65.0 0.3 2.5e-17 63.2 0.2 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EKX74278.1 - 2.4e-12 47.0 0.1 6.2e-10 39.1 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase Colicin_D PF11429.8 EKX74278.1 - 0.045 14.2 0.5 0.12 12.8 0.5 1.7 1 0 0 1 1 1 0 Colicin D GPI2 PF06432.11 EKX74280.1 - 1.8e-29 103.1 10.0 2.1e-29 102.8 10.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase DUF2115 PF09888.9 EKX74281.1 - 0.18 12.3 0.8 0.3 11.6 0.4 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) Exo_endo_phos PF03372.23 EKX74283.1 - 0.0032 17.0 0.0 0.0069 15.9 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PriCT_1 PF08708.11 EKX74283.1 - 0.046 13.5 0.1 0.12 12.1 0.1 1.6 1 0 0 1 1 1 0 Primase C terminal 1 (PriCT-1) mRNA_cap_enzyme PF01331.19 EKX74284.1 - 0.00017 21.5 0.5 0.0017 18.2 0.0 2.5 2 1 0 2 2 2 1 mRNA capping enzyme, catalytic domain Acylphosphatase PF00708.18 EKX74285.1 - 2.7e-20 72.6 0.7 3.3e-20 72.3 0.7 1.1 1 0 0 1 1 1 1 Acylphosphatase DUF2871 PF11070.8 EKX74285.1 - 0.086 13.1 0.1 0.13 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2871) FerI PF08151.12 EKX74285.1 - 0.15 12.2 0.0 0.26 11.4 0.0 1.3 1 0 0 1 1 1 0 FerI (NUC094) domain DSPc PF00782.20 EKX74286.1 - 4.2e-10 39.5 0.0 1.5e-09 37.7 0.0 1.7 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EKX74286.1 - 0.00053 19.6 0.0 0.00079 19.1 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EKX74286.1 - 0.038 14.1 0.0 0.059 13.5 0.0 1.3 1 1 0 1 1 1 0 Inositol hexakisphosphate AP2 PF00847.20 EKX74287.1 - 9.2e-13 48.2 1.9 5.2e-05 23.4 0.0 2.5 2 0 0 2 2 2 2 AP2 domain SUIM_assoc PF16619.5 EKX74287.1 - 0.0081 16.2 1.6 0.13 12.4 0.0 2.7 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 CaATP_NAI PF12515.8 EKX74287.1 - 0.066 12.8 0.2 0.18 11.5 0.2 1.7 1 0 0 1 1 1 0 Ca2+-ATPase N terminal autoinhibitory domain TPR_1 PF00515.28 EKX74288.1 - 3.5e-12 45.6 0.5 0.0033 17.2 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EKX74288.1 - 4.4e-12 45.1 0.1 0.0016 18.4 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EKX74288.1 - 1.5e-05 25.0 2.4 0.0045 17.0 0.1 2.7 2 1 1 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 EKX74288.1 - 0.00026 21.4 0.0 20 6.1 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EKX74288.1 - 0.00065 19.7 5.7 2.4 8.6 0.0 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat YfiO PF13525.6 EKX74288.1 - 0.0069 16.1 1.9 0.22 11.2 1.9 2.4 1 1 0 1 1 1 1 Outer membrane lipoprotein COPI_C PF06957.11 EKX74288.1 - 0.016 14.0 0.9 1.1 8.0 0.1 2.1 2 0 0 2 2 2 0 Coatomer (COPI) alpha subunit C-terminus Alkyl_sulf_dimr PF14863.6 EKX74288.1 - 0.042 14.3 0.3 0.3 11.5 0.3 2.2 1 1 0 1 1 1 0 Alkyl sulfatase dimerisation ANAPC3 PF12895.7 EKX74288.1 - 0.046 13.9 0.6 0.41 10.9 0.1 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EKX74288.1 - 0.047 13.8 0.0 0.074 13.2 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 EKX74288.1 - 0.14 12.9 0.0 14 6.4 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 EKX74288.1 - 0.21 11.9 0.5 5.5 7.3 0.1 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat ubiquitin PF00240.23 EKX74289.1 - 3.5e-19 68.3 0.0 6.7e-19 67.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EKX74289.1 - 6e-08 32.4 0.0 1.1e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.31 EKX74289.1 - 0.00011 22.1 0.1 0.00025 20.9 0.1 1.7 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD_2 PF13881.6 EKX74289.1 - 0.0006 19.9 0.4 0.0024 18.0 0.1 2.1 2 1 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like HOIP-UBA PF16678.5 EKX74289.1 - 0.012 15.6 0.2 0.028 14.4 0.0 1.7 2 0 0 2 2 2 0 HOIP UBA domain pair Joubert PF15392.6 EKX74289.1 - 0.016 14.9 1.9 0.019 14.7 0.1 1.8 2 0 0 2 2 2 0 Joubert syndrome-associated DUF2407 PF10302.9 EKX74289.1 - 0.018 15.6 0.3 0.072 13.7 0.0 1.9 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain DUF5018 PF16410.5 EKX74289.1 - 0.072 11.8 0.1 0.12 11.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5018) TFIIA PF03153.13 EKX74289.1 - 0.13 12.3 12.4 0.16 12.0 12.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF5421 PF17458.2 EKX74289.1 - 0.37 10.1 2.4 0.6 9.5 2.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5421) ArsC PF03960.15 EKX74289.1 - 0.39 10.8 2.8 12 6.0 0.3 2.5 1 1 1 2 2 2 0 ArsC family UAA PF08449.11 EKX74290.1 - 4.8e-36 124.5 21.2 1.9e-35 122.5 21.0 2.0 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 EKX74290.1 - 1.6e-08 34.8 27.9 7.6e-07 29.4 10.6 2.7 2 1 1 3 3 3 2 EamA-like transporter family UFD1 PF03152.14 EKX74291.1 - 3.9e-36 124.1 0.5 1.6e-35 122.1 0.5 1.8 1 1 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 PRORP PF16953.5 EKX74292.1 - 1.6e-05 24.5 0.0 0.51 9.8 0.0 3.4 3 0 0 3 3 3 3 Protein-only RNase P OMPdecase PF00215.24 EKX74293.1 - 4.1e-25 88.7 0.0 5.1e-25 88.4 0.0 1.1 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family SNF2_N PF00176.23 EKX74294.1 - 2.8e-60 203.9 0.1 2.8e-60 203.9 0.1 2.2 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EKX74294.1 - 6e-18 65.2 0.0 3.2e-17 62.9 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HSA PF07529.13 EKX74294.1 - 0.0029 17.9 4.0 0.0029 17.9 4.0 3.3 3 1 1 4 4 4 2 HSA PLDc_2 PF13091.6 EKX74296.1 - 2.2e-11 43.8 0.0 3.6e-05 23.7 0.0 2.6 2 1 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EKX74296.1 - 0.0061 16.7 4.8 0.1 12.8 0.1 3.6 3 0 0 3 3 3 1 Phospholipase D Active site motif DUF1959 PF09218.10 EKX74296.1 - 0.049 13.8 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1959) zf_Rg PF17915.1 EKX74297.1 - 0.09 12.2 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 Reverse gyrase zinc finger Ribosomal_L23 PF00276.20 EKX74298.1 - 3.1e-14 53.1 0.1 5.9e-14 52.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L23 ACDC PF14733.6 EKX74299.1 - 7.2e-12 45.5 0.0 1.9e-11 44.1 0.0 1.7 1 0 0 1 1 1 1 AP2-coincident C-terminal AP2 PF00847.20 EKX74299.1 - 3.6e-11 43.1 1.2 8e-11 42.0 1.2 1.6 1 0 0 1 1 1 1 AP2 domain ELK PF03789.13 EKX74299.1 - 0.13 12.4 0.2 0.4 10.8 0.2 1.9 1 0 0 1 1 1 0 ELK domain DUF3287 PF11690.8 EKX74300.1 - 0.0032 17.2 0.4 0.0041 16.8 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3287) HtrL_YibB PF09612.10 EKX74300.1 - 0.018 14.6 0.2 0.022 14.3 0.2 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (HtrL_YibB) DNA_gyraseB PF00204.25 EKX74301.1 - 6.7e-43 146.2 0.1 1.3e-42 145.3 0.1 1.5 1 0 0 1 1 1 1 DNA gyrase B DNA_gyraseB_C PF00986.21 EKX74301.1 - 2e-23 82.3 0.1 4e-23 81.4 0.1 1.5 1 0 0 1 1 1 1 DNA gyrase B subunit, carboxyl terminus Toprim PF01751.22 EKX74301.1 - 5.7e-16 58.6 0.1 4.9e-14 52.4 0.0 3.3 3 0 0 3 3 3 1 Toprim domain HATPase_c PF02518.26 EKX74301.1 - 4e-13 49.8 0.1 6.6e-12 45.9 0.1 2.7 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EKX74301.1 - 0.06 13.2 0.2 0.23 11.3 0.2 2.1 1 1 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HK PF02110.15 EKX74302.1 - 0.00015 21.2 0.0 0.00022 20.7 0.0 1.2 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family Peptidase_M41 PF01434.18 EKX74303.1 - 1.2e-62 211.2 0.4 1.8e-62 210.6 0.4 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EKX74303.1 - 1.9e-42 144.8 0.1 6.6e-42 143.1 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EKX74303.1 - 2.2e-12 46.6 0.0 5.5e-12 45.3 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 EKX74303.1 - 4.5e-06 26.5 0.4 2e-05 24.4 0.0 2.2 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EKX74303.1 - 1.9e-05 25.1 0.2 0.0057 17.0 0.0 2.6 2 1 1 3 3 2 1 AAA ATPase domain AAA_22 PF13401.6 EKX74303.1 - 7.6e-05 23.0 2.1 0.057 13.7 0.1 4.0 2 1 2 4 4 4 1 AAA domain TIP49 PF06068.13 EKX74303.1 - 0.00022 20.6 0.0 0.0004 19.7 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_5 PF07728.14 EKX74303.1 - 0.00076 19.5 1.0 0.0025 17.8 0.1 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EKX74303.1 - 0.0025 17.9 0.6 0.021 15.0 0.0 2.6 2 1 0 3 3 3 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 EKX74303.1 - 0.0043 16.8 0.0 0.0094 15.7 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_28 PF13521.6 EKX74303.1 - 0.0056 16.9 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EKX74303.1 - 0.0056 16.1 0.2 0.011 15.1 0.2 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 EKX74303.1 - 0.0076 15.5 0.1 0.021 14.1 0.1 1.7 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.6 EKX74303.1 - 0.016 15.4 0.0 0.03 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EKX74303.1 - 0.017 15.1 0.0 0.044 13.8 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 EKX74303.1 - 0.021 14.0 0.0 0.039 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_17 PF13207.6 EKX74303.1 - 0.028 14.8 0.0 0.068 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EKX74303.1 - 0.075 12.5 0.1 0.25 10.8 0.1 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 EKX74303.1 - 0.078 12.9 0.2 0.16 11.9 0.2 1.5 1 0 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 EKX74303.1 - 0.1 12.3 0.0 0.31 10.7 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_18 PF13238.6 EKX74303.1 - 0.11 13.1 0.0 0.26 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EKX74303.1 - 0.14 11.9 0.1 0.59 9.8 0.1 2.0 1 1 0 1 1 1 0 Sigma-54 interaction domain Vps16_N PF04841.13 EKX74304.1 - 1.8e-21 76.4 0.0 1.7e-20 73.2 0.0 2.1 1 1 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.12 EKX74304.1 - 6.5e-16 58.3 1.9 9.1e-08 31.5 0.1 2.4 2 0 0 2 2 2 2 Vps16, C-terminal region WD40 PF00400.32 EKX74305.1 - 3.5e-26 90.9 10.4 0.00015 22.5 0.1 7.0 6 1 1 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKX74305.1 - 9.7e-11 41.8 0.0 0.011 16.1 0.0 5.6 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EKX74305.1 - 1.2e-05 25.3 0.2 0.004 17.0 0.0 3.1 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EKX74305.1 - 0.0031 16.5 0.0 0.48 9.3 0.0 2.8 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Ribosomal_L1 PF00687.21 EKX74306.1 - 3.3e-18 66.2 0.9 4.8e-18 65.6 0.7 1.4 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family Syntaxin_2 PF14523.6 EKX74307.1 - 2.3 8.6 7.1 8.6 6.8 1.0 2.8 2 0 0 2 2 2 0 Syntaxin-like protein SH3_1 PF00018.28 EKX74308.1 - 0.065 12.9 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 SH3 domain SPC22 PF04573.12 EKX74310.1 - 0.32 10.4 2.6 3.8 7.0 0.0 2.6 2 1 1 3 3 3 0 Signal peptidase subunit Rpp20 PF12328.8 EKX74311.1 - 2.7e-05 24.2 0.1 0.063 13.2 0.0 2.9 2 1 0 2 2 2 2 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 EKX74311.1 - 0.013 15.3 0.0 0.03 14.1 0.0 1.6 1 1 0 1 1 1 0 Alba RPAP2_Rtr1 PF04181.13 EKX74314.1 - 1.8e-15 57.0 1.4 3.2e-15 56.2 1.4 1.4 1 0 0 1 1 1 1 Rtr1/RPAP2 family Glyco_tranf_2_2 PF10111.9 EKX74314.1 - 0.011 15.2 0.0 0.021 14.3 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Cpn60_TCP1 PF00118.24 EKX74315.1 - 3.4e-147 491.0 5.5 3.9e-147 490.8 5.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family zf-C3HC4_3 PF13920.6 EKX74319.1 - 1.5e-14 53.6 8.8 2.7e-14 52.8 8.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EKX74319.1 - 2.5e-06 27.2 10.1 6e-06 26.0 10.1 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EKX74319.1 - 2.5e-05 24.5 11.2 5.6e-05 23.4 11.2 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EKX74319.1 - 0.00021 21.1 11.2 0.00046 20.0 11.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EKX74319.1 - 0.0066 16.4 9.5 0.0066 16.4 9.5 2.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EKX74319.1 - 0.032 14.3 8.3 0.088 12.9 8.0 2.0 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EKX74319.1 - 0.55 10.4 11.2 1.3 9.2 11.2 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-P11 PF03854.14 EKX74319.1 - 1.3 8.8 10.0 3.3 7.4 10.0 1.7 1 1 0 1 1 1 0 P-11 zinc finger zf-RING_4 PF14570.6 EKX74319.1 - 3.2 7.6 9.7 8.3 6.3 9.7 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain PqiA PF04403.13 EKX74321.1 - 1.1e-06 28.5 14.0 0.00028 20.8 2.8 3.0 3 0 0 3 3 3 2 Paraquat-inducible protein A Neurensin PF14927.6 EKX74321.1 - 0.0098 15.6 0.5 0.1 12.3 0.1 2.8 2 1 0 2 2 2 1 Neurensin TerB_N PF13208.6 EKX74321.1 - 0.062 13.0 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 TerB N-terminal domain Myosin_head PF00063.21 EKX74322.1 - 2e-176 588.1 19.7 3e-176 587.6 19.7 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) RCC1 PF00415.18 EKX74322.1 - 2.1e-33 114.7 1.4 2.1e-12 47.4 0.0 5.7 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EKX74322.1 - 1.1e-21 76.0 11.6 4e-07 29.7 0.0 5.4 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat IQ PF00612.27 EKX74322.1 - 4.6e-15 53.9 28.2 0.00041 19.9 0.8 6.8 8 0 0 8 8 8 4 IQ calmodulin-binding motif CagY_M PF07337.11 EKX74322.1 - 0.0025 17.4 0.0 0.031 13.9 0.0 2.5 2 0 0 2 2 2 1 DC-EC Repeat AAA_16 PF13191.6 EKX74322.1 - 0.012 16.0 0.1 0.16 12.3 0.0 2.5 3 0 0 3 3 3 0 AAA ATPase domain AAA_22 PF13401.6 EKX74322.1 - 0.037 14.3 0.0 0.11 12.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain CbiA PF01656.23 EKX74322.1 - 0.07 13.2 0.1 1.5 8.8 0.0 2.7 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain BBS1 PF14779.6 EKX74323.1 - 0.014 14.9 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 1 Pkinase PF00069.25 EKX74324.1 - 2.2e-18 66.6 0.0 3.8e-18 65.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKX74324.1 - 7.5e-09 35.2 0.0 1.3e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase ArfGap PF01412.18 EKX74325.1 - 6.6e-29 100.4 0.0 1.6e-28 99.1 0.0 1.7 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Sec34 PF04136.15 EKX74325.1 - 0.044 13.7 1.9 0.39 10.6 1.0 2.3 1 1 1 2 2 2 0 Sec34-like family Pro_isomerase PF00160.21 EKX74326.1 - 3.7e-39 134.5 0.2 4.3e-39 134.3 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PseudoU_synth_1 PF01416.20 EKX74327.1 - 8.8e-14 51.9 0.1 1.8e-11 44.5 0.0 2.6 2 1 0 2 2 2 2 tRNA pseudouridine synthase DUF2344 PF10105.9 EKX74327.1 - 0.069 13.0 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) ATP_bind_1 PF03029.17 EKX74328.1 - 4.6e-72 242.7 0.3 5.4e-72 242.5 0.3 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MeaB PF03308.16 EKX74328.1 - 8.5e-05 21.7 0.1 0.00023 20.3 0.1 1.5 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 EKX74328.1 - 0.00018 21.1 0.1 0.0044 16.6 0.1 2.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain NTPase_1 PF03266.15 EKX74328.1 - 0.00023 21.1 0.1 0.00052 20.0 0.1 1.6 1 1 0 1 1 1 1 NTPase AAA_31 PF13614.6 EKX74328.1 - 0.00054 19.9 0.6 0.13 12.1 0.5 2.3 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EKX74328.1 - 0.00064 19.5 0.1 0.0011 18.7 0.1 1.5 1 0 0 1 1 1 1 AAA domain Pox_A32 PF04665.12 EKX74328.1 - 0.0019 17.7 0.0 0.0046 16.5 0.0 1.6 1 0 0 1 1 1 1 Poxvirus A32 protein SRP54 PF00448.22 EKX74328.1 - 0.0021 17.7 0.5 0.015 15.0 0.2 2.0 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_22 PF13401.6 EKX74328.1 - 0.0025 18.1 0.0 0.0045 17.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EKX74328.1 - 0.0027 16.9 0.0 0.0037 16.5 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain MobB PF03205.14 EKX74328.1 - 0.003 17.5 0.0 0.0062 16.4 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B NACHT PF05729.12 EKX74328.1 - 0.0042 17.0 0.1 0.0064 16.4 0.1 1.5 1 1 0 1 1 1 1 NACHT domain MipZ PF09140.11 EKX74328.1 - 0.0044 16.3 0.0 0.008 15.5 0.0 1.4 1 1 0 1 1 1 1 ATPase MipZ AAA_16 PF13191.6 EKX74328.1 - 0.0045 17.4 0.0 0.0055 17.1 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain ATPase_2 PF01637.18 EKX74328.1 - 0.0046 16.9 0.1 0.007 16.3 0.1 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_33 PF13671.6 EKX74328.1 - 0.0061 16.7 0.0 0.0096 16.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EKX74328.1 - 0.0091 16.1 0.0 0.027 14.5 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 EKX74328.1 - 0.011 15.4 0.0 0.65 9.6 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 EKX74328.1 - 0.021 14.4 0.1 0.04 13.4 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region TrwB_AAD_bind PF10412.9 EKX74328.1 - 0.021 13.8 0.0 0.034 13.1 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_14 PF13173.6 EKX74328.1 - 0.025 14.6 0.2 0.05 13.6 0.2 1.7 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 EKX74328.1 - 0.036 13.1 0.0 0.054 12.6 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.6 EKX74328.1 - 0.042 13.6 0.1 0.064 13.0 0.1 1.2 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EKX74328.1 - 0.066 13.5 0.1 0.18 12.1 0.1 1.6 2 0 0 2 2 1 0 AAA domain DUF87 PF01935.17 EKX74328.1 - 0.068 13.3 0.1 0.15 12.1 0.1 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain Viral_helicase1 PF01443.18 EKX74328.1 - 0.072 12.8 0.1 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase CbiA PF01656.23 EKX74328.1 - 0.097 12.7 0.0 0.1 12.7 0.0 1.2 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Septin PF00735.18 EKX74328.1 - 0.11 11.8 0.0 5.6 6.1 0.0 2.1 2 0 0 2 2 2 0 Septin CLP1_P PF16575.5 EKX74328.1 - 0.12 12.2 0.0 3.6 7.3 0.0 2.2 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop TsaE PF02367.17 EKX74328.1 - 0.17 11.9 0.1 0.38 10.8 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EKX74328.1 - 0.17 12.4 0.0 0.29 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 EKX74328.1 - 0.18 11.1 0.0 0.36 10.1 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family Sec34 PF04136.15 EKX74328.1 - 0.21 11.5 2.0 8 6.3 0.0 2.6 1 1 1 2 2 2 0 Sec34-like family Mito_carr PF00153.27 EKX74329.1 - 3.4e-34 116.6 6.9 3e-17 62.3 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Pro_isomerase PF00160.21 EKX74330.1 - 9e-38 130.0 0.0 1.2e-37 129.6 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TFIIA PF03153.13 EKX74331.1 - 6.3e-08 33.0 8.8 1.2e-07 32.1 8.8 1.5 1 1 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF5089 PF17002.5 EKX74331.1 - 0.062 13.2 6.1 0.094 12.6 6.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5089) BUD22 PF09073.10 EKX74331.1 - 0.39 10.0 11.6 0.51 9.6 11.6 1.0 1 0 0 1 1 1 0 BUD22 Pheromone PF08015.11 EKX74331.1 - 2.4 9.3 6.9 0.5 11.4 1.8 2.3 1 1 1 2 2 2 0 Fungal mating-type pheromone Kinesin PF00225.23 EKX74332.1 - 3.8e-91 305.5 4.5 6.7e-91 304.7 4.5 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EKX74332.1 - 1.6e-25 89.8 1.1 3.8e-25 88.6 1.1 1.6 1 0 0 1 1 1 1 Microtubule binding EF1_GNE PF00736.19 EKX74333.1 - 2.8e-28 97.9 1.3 5.5e-28 97.0 1.3 1.5 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain E7 PF00527.18 EKX74333.1 - 1.7 8.9 3.9 55 4.1 0.6 3.2 3 0 0 3 3 3 0 E7 protein, Early protein NAD_kinase PF01513.21 EKX74334.1 - 4.8e-06 26.0 0.0 0.096 11.9 0.0 2.9 3 0 0 3 3 3 2 ATP-NAD kinase DAGK_cat PF00781.24 EKX74334.1 - 0.14 11.8 0.0 0.3 10.7 0.0 1.6 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Aminotran_5 PF00266.19 EKX74335.1 - 8.9e-118 393.4 0.0 1e-117 393.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EKX74335.1 - 1.9e-09 37.2 0.1 3e-09 36.5 0.1 1.4 1 1 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EKX74335.1 - 0.00044 18.9 0.1 0.00072 18.2 0.1 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 EKX74335.1 - 0.00071 18.9 0.0 0.00086 18.7 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase GDC-P PF02347.16 EKX74335.1 - 0.01 14.7 0.0 0.017 14.0 0.0 1.3 1 0 0 1 1 1 0 Glycine cleavage system P-protein DegT_DnrJ_EryC1 PF01041.17 EKX74335.1 - 0.081 12.2 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family tRNA-synt_1g PF09334.11 EKX74337.1 - 1.8e-83 280.5 0.1 9.5e-47 159.6 0.0 2.2 1 1 1 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EKX74337.1 - 1.1e-27 96.6 1.0 1.9e-17 62.8 0.0 3.4 1 1 3 4 4 4 4 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EKX74337.1 - 5.3e-14 52.3 0.0 2.5e-06 27.0 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 EKX74337.1 - 6.5e-05 22.0 0.0 0.00098 18.1 0.0 2.4 2 0 0 2 2 2 1 tRNA synthetases class I (K) tRNA-synt_1d PF00750.19 EKX74337.1 - 0.11 11.5 0.0 0.35 9.8 0.0 1.7 2 0 0 2 2 2 0 tRNA synthetases class I (R) ABC_tran PF00005.27 EKX74338.1 - 4e-31 108.4 0.0 1.4e-17 64.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EKX74338.1 - 2.7e-06 27.4 0.4 0.23 11.3 0.1 3.4 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EKX74338.1 - 1.5e-05 25.4 0.0 0.035 14.5 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EKX74338.1 - 7.5e-05 22.4 0.8 0.22 11.3 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_30 PF13604.6 EKX74338.1 - 0.00017 21.4 0.1 0.14 11.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 EKX74338.1 - 0.00053 19.3 0.2 0.36 10.1 0.0 2.8 2 0 0 2 2 2 1 Zeta toxin DnaB_C PF03796.15 EKX74338.1 - 0.00058 19.3 0.0 0.066 12.5 0.0 2.2 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain RsgA_GTPase PF03193.16 EKX74338.1 - 0.00078 19.4 1.1 0.065 13.1 0.2 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_18 PF13238.6 EKX74338.1 - 0.002 18.7 0.1 1.6 9.3 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EKX74338.1 - 0.0024 18.1 0.0 0.57 10.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 EKX74338.1 - 0.0051 16.9 2.3 0.1 12.6 0.1 2.4 2 0 0 2 2 2 1 Helicase HerA, central domain MMR_HSR1 PF01926.23 EKX74338.1 - 0.012 15.7 0.2 0.2 11.8 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase SMC_N PF02463.19 EKX74338.1 - 0.012 15.1 0.3 0.18 11.2 0.0 2.4 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EKX74338.1 - 0.014 15.9 5.7 0.84 10.1 1.0 2.5 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EKX74338.1 - 0.015 15.2 0.5 2.9 7.8 0.1 2.6 2 0 0 2 2 2 0 NACHT domain T2SSE PF00437.20 EKX74338.1 - 0.016 14.3 1.4 2.2 7.3 0.1 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein MeaB PF03308.16 EKX74338.1 - 0.023 13.7 0.7 0.049 12.6 0.1 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP_bind_1 PF03029.17 EKX74338.1 - 0.038 13.8 0.1 6.1 6.6 0.0 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_15 PF13175.6 EKX74338.1 - 0.038 13.7 1.6 6 6.5 0.2 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_25 PF13481.6 EKX74338.1 - 0.055 13.1 0.1 1 8.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EKX74338.1 - 0.06 12.5 0.9 1 8.5 0.1 2.5 2 0 0 2 2 2 0 NB-ARC domain FtsK_SpoIIIE PF01580.18 EKX74338.1 - 0.076 12.4 3.5 1.7 7.9 0.1 2.5 3 0 0 3 3 3 0 FtsK/SpoIIIE family cobW PF02492.19 EKX74338.1 - 0.086 12.4 2.6 6.7 6.3 0.1 2.6 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.23 EKX74338.1 - 0.11 12.6 2.0 7.6 6.6 0.0 2.7 3 0 0 3 3 2 0 Dynamin family ATPase_2 PF01637.18 EKX74338.1 - 0.11 12.4 0.0 18 5.1 0.0 2.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 EKX74338.1 - 0.12 12.1 1.0 4.8 6.9 0.0 3.2 4 0 0 4 4 4 0 IstB-like ATP binding protein NTPase_1 PF03266.15 EKX74338.1 - 0.15 11.9 0.3 8.1 6.3 0.1 2.4 2 0 0 2 2 2 0 NTPase TsaE PF02367.17 EKX74338.1 - 0.19 11.7 1.2 3.1 7.8 0.1 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE BCLP PF12304.8 EKX74338.1 - 0.85 9.1 10.6 0.099 12.2 1.6 3.3 3 0 0 3 3 3 0 Beta-casein like protein WD40 PF00400.32 EKX74339.1 - 2.7e-23 81.8 8.0 4.3e-05 24.2 0.0 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKX74339.1 - 2.7e-12 46.8 0.2 8.8e-06 25.9 0.2 4.6 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain EntA_Immun PF08951.10 EKX74340.1 - 0.13 12.6 2.6 0.24 11.8 1.5 2.0 2 0 0 2 2 2 0 Enterocin A Immunity PDCD2_C PF04194.13 EKX74341.1 - 8.7e-30 104.1 2.0 2e-28 99.7 1.4 2.1 2 0 0 2 2 2 1 Programmed cell death protein 2, C-terminal putative domain Zn-ribbon_8 PF09723.10 EKX74341.1 - 1.3 9.2 5.4 2.5 8.3 0.0 3.7 4 0 0 4 4 4 0 Zinc ribbon domain Cir_N PF10197.9 EKX74342.1 - 1e-12 48.0 9.0 1e-12 48.0 9.0 2.6 2 0 0 2 2 2 1 N-terminal domain of CBF1 interacting co-repressor CIR Slu7 PF11708.8 EKX74342.1 - 0.0019 18.0 0.2 0.0019 18.0 0.2 2.8 2 1 1 3 3 3 1 Pre-mRNA splicing Prp18-interacting factor Med26_C PF15693.5 EKX74342.1 - 2.4 8.2 8.9 0.41 10.8 4.3 1.8 2 0 0 2 2 2 0 Mediator complex subunit 26 C-terminal GTP_EFTU PF00009.27 EKX74343.1 - 1.7e-53 181.0 0.0 3.5e-53 180.0 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EKX74343.1 - 3.5e-16 59.0 0.0 5.5e-15 55.2 0.0 2.5 2 0 0 2 2 2 1 Elongation factor G C-terminus EFG_II PF14492.6 EKX74343.1 - 7.7e-06 25.9 0.0 1.7e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EKX74343.1 - 0.003 17.9 0.0 0.0063 16.9 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EKX74343.1 - 0.0062 16.6 0.1 0.027 14.5 0.1 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase EFG_IV PF03764.18 EKX74343.1 - 0.098 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Elongation factor G, domain IV Inhibitor_I42 PF09394.10 EKX74344.1 - 0.093 13.2 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 Chagasin family peptidase inhibitor I42 NAP PF00956.18 EKX74345.1 - 1.2e-19 70.5 6.5 2.8e-13 49.7 0.1 2.5 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) Mst1_SARAH PF11629.8 EKX74345.1 - 6.9e-05 22.9 2.5 0.00019 21.4 2.5 1.8 1 0 0 1 1 1 1 C terminal SARAH domain of Mst1 Branch_AA_trans PF05525.13 EKX74347.1 - 0.059 12.2 0.1 0.09 11.6 0.1 1.2 1 0 0 1 1 1 0 Branched-chain amino acid transport protein Vut_1 PF02592.15 EKX74347.1 - 0.059 13.7 0.3 0.1 12.9 0.3 1.3 1 0 0 1 1 1 0 Putative vitamin uptake transporter Pkinase PF00069.25 EKX74349.1 - 1.7e-78 263.6 0.2 2.4e-78 263.1 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKX74349.1 - 1.2e-40 139.4 0.0 1.7e-40 138.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 EKX74349.1 - 2.7e-28 95.4 7.9 2.6e-07 29.7 0.1 4.9 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EKX74349.1 - 2.9e-25 88.5 9.2 8.6e-12 45.3 0.3 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EKX74349.1 - 1.1e-22 77.9 6.9 8.3e-05 22.2 0.0 4.9 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EKX74349.1 - 2.2e-21 74.3 8.1 5.6e-05 22.4 0.2 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EKX74349.1 - 1.2e-20 73.1 8.2 3.3e-07 30.0 0.1 5.2 3 1 2 5 5 5 4 EF-hand domain pair Kinase-like PF14531.6 EKX74349.1 - 1.3e-07 31.2 0.0 9.5e-05 21.8 0.0 2.6 2 1 0 2 2 2 2 Kinase-like SPARC_Ca_bdg PF10591.9 EKX74349.1 - 1.2e-05 25.6 1.3 0.059 13.7 0.1 3.2 1 1 2 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region Pkinase_fungal PF17667.1 EKX74349.1 - 2.6e-05 23.2 0.0 4.5e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase EF-hand_4 PF12763.7 EKX74349.1 - 0.00036 20.4 4.7 0.46 10.5 0.4 4.3 2 1 2 4 4 4 1 Cytoskeletal-regulatory complex EF hand Kdo PF06293.14 EKX74349.1 - 0.00041 19.8 0.0 0.0012 18.2 0.0 1.8 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family EF-hand_9 PF14658.6 EKX74349.1 - 0.0006 20.1 0.2 0.15 12.4 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain APH PF01636.23 EKX74349.1 - 0.0063 16.5 0.0 0.018 14.9 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 EKX74349.1 - 0.021 14.5 1.1 1.6 8.3 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 EF-hand_11 PF08976.11 EKX74349.1 - 0.025 15.5 0.3 2.1 9.2 0.1 2.7 1 1 1 2 2 2 0 EF-hand domain TGT PF01702.18 EKX74350.1 - 4.8e-127 423.9 0.0 5.7e-127 423.7 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase TFIIE_alpha PF02002.17 EKX74351.1 - 0.0023 17.7 3.1 0.057 13.3 3.1 2.5 1 1 0 1 1 1 1 TFIIE alpha subunit HTH_12 PF08461.10 EKX74351.1 - 0.02 14.8 1.2 0.35 10.8 0.1 3.4 4 0 0 4 4 4 0 Ribonuclease R winged-helix domain HTH_20 PF12840.7 EKX74351.1 - 0.079 13.0 0.1 0.18 11.9 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Imm3 PF14425.6 EKX74351.1 - 0.085 12.9 0.3 0.19 11.8 0.3 1.6 1 0 0 1 1 1 0 Immunity protein Imm3 GntR PF00392.21 EKX74351.1 - 0.13 11.9 0.1 0.26 10.9 0.1 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family ubiquitin PF00240.23 EKX74352.1 - 5.7e-35 118.9 0.3 7.4e-35 118.5 0.3 1.1 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 EKX74352.1 - 1.2e-30 105.2 11.0 1.8e-30 104.6 11.0 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 EKX74352.1 - 5.9e-17 61.3 0.4 7.9e-17 60.9 0.4 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EKX74352.1 - 6e-06 26.6 0.1 2.1e-05 24.9 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EKX74352.1 - 0.0036 17.2 0.0 0.0048 16.8 0.0 1.2 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EKX74352.1 - 0.0054 16.8 0.0 0.013 15.5 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EKX74352.1 - 0.0067 16.8 0.0 0.011 16.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_4 PF18036.1 EKX74352.1 - 0.024 14.7 0.7 6.9 6.8 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 EKX74352.1 - 0.059 13.9 0.0 0.069 13.7 0.0 1.3 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Fer2_3 PF13085.6 EKX74352.1 - 1.5 8.8 5.0 74 3.4 4.1 2.5 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain DDOST_48kD PF03345.14 EKX74354.1 - 2.7e-11 43.0 0.1 3.6e-11 42.5 0.1 1.3 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Sugar_tr PF00083.24 EKX74355.1 - 6.8e-60 203.2 33.0 8.5e-60 202.9 33.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EKX74355.1 - 7.9e-10 38.2 30.2 7.9e-10 38.2 30.2 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EKX74355.1 - 0.00024 19.7 1.4 0.00024 19.7 1.4 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) HATPase_c PF02518.26 EKX74356.1 - 2.4e-09 37.7 0.0 2.8e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EKX74356.1 - 1.2e-07 31.6 0.0 1.5e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 EKX74356.1 - 0.011 15.6 0.2 0.018 14.9 0.2 1.4 1 1 0 1 1 1 0 GHKL domain SNARE_assoc PF09335.11 EKX74358.1 - 1.3e-24 87.0 10.7 1.3e-24 87.0 10.7 1.8 2 0 0 2 2 2 1 SNARE associated Golgi protein CoA_binding_3 PF13727.6 EKX74358.1 - 0.33 11.0 8.5 1.4 8.9 3.5 2.4 2 0 0 2 2 2 0 CoA-binding domain PNTB PF02233.16 EKX74358.1 - 0.43 9.4 3.1 0.67 8.8 2.3 1.6 2 0 0 2 2 2 0 NAD(P) transhydrogenase beta subunit DnaJ PF00226.31 EKX74359.1 - 0.00078 19.5 0.3 0.0035 17.4 0.3 2.1 1 1 0 1 1 1 1 DnaJ domain CDC24 PF06395.11 EKX74359.1 - 0.076 13.3 0.2 0.26 11.6 0.1 1.9 2 0 0 2 2 2 0 CDC24 Calponin FmiP_Thoc5 PF09766.9 EKX74360.1 - 0.016 14.5 0.3 0.034 13.4 0.3 1.4 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 FtsJ PF01728.19 EKX74360.1 - 0.031 14.4 0.0 0.055 13.6 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Myb_DNA-binding PF00249.31 EKX74362.1 - 3e-06 27.3 0.2 7.3e-06 26.1 0.2 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EKX74362.1 - 6.8e-06 26.3 0.5 1.9e-05 24.8 0.5 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain CNOT1_CAF1_bind PF16415.5 EKX74363.1 - 8.5e-71 237.9 4.4 8.5e-71 237.9 4.4 1.7 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain Not1 PF04054.15 EKX74363.1 - 2.7e-46 158.1 1.2 3.4e-37 128.2 0.0 3.0 3 0 0 3 3 3 2 CCR4-Not complex component, Not1 CNOT1_TTP_bind PF16417.5 EKX74363.1 - 3.1e-40 137.4 1.1 2.5e-39 134.4 0.1 2.6 3 0 0 3 3 3 1 CCR4-NOT transcription complex subunit 1 TTP binding domain DUF3819 PF12842.7 EKX74363.1 - 5.8e-37 126.9 4.4 1.9e-36 125.2 4.4 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) FXR_C3 PF16097.5 EKX74363.1 - 0.31 11.8 2.3 0.66 10.7 2.3 1.5 1 0 0 1 1 1 0 Fragile X-related 1 protein C-terminal region 3 WW PF00397.26 EKX74364.1 - 1.3e-05 25.2 7.3 2.9e-05 24.1 7.3 1.7 1 0 0 1 1 1 1 WW domain DUF507 PF04368.13 EKX74364.1 - 0.11 12.4 12.1 0.11 12.4 1.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF507) DNA_pol3_delta2 PF13177.6 EKX74365.1 - 4.9e-14 52.4 0.0 7.8e-14 51.8 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EKX74365.1 - 0.0019 18.2 0.1 0.004 17.1 0.1 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 EKX74365.1 - 0.11 12.2 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EKX74365.1 - 0.18 12.2 0.1 1.1 9.7 0.1 2.1 1 1 0 1 1 1 0 AAA ATPase domain Hydrolase_4 PF12146.8 EKX74366.1 - 1e-18 67.5 0.1 5.9e-18 65.0 0.0 2.2 2 1 0 2 2 2 1 Serine aminopeptidase, S33 FAINT PF04385.15 EKX74366.1 - 7.2e-12 45.2 8.9 0.0003 20.8 0.0 5.3 5 0 0 5 5 5 3 Domain of unknown function, DUF529 Abhydrolase_6 PF12697.7 EKX74366.1 - 0.00027 21.6 0.0 0.00072 20.2 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EKX74366.1 - 0.00094 18.9 0.3 0.011 15.5 0.1 2.6 3 1 0 3 3 3 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 EKX74366.1 - 0.013 15.6 0.0 0.033 14.3 0.0 1.6 1 0 0 1 1 1 0 TAP-like protein Abhydrolase_2 PF02230.16 EKX74366.1 - 0.11 12.3 0.1 18 5.0 0.0 3.0 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Sterile PF03015.19 EKX74366.1 - 0.11 12.7 3.2 0.31 11.3 0.3 2.9 3 0 0 3 3 3 0 Male sterility protein Peptidase_S9 PF00326.21 EKX74366.1 - 0.12 11.9 0.0 1.6 8.2 0.1 2.6 3 0 0 3 3 3 0 Prolyl oligopeptidase family FAINT PF04385.15 EKX74367.1 - 0.054 13.6 0.1 0.13 12.4 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function, DUF529 RAP PF08373.10 EKX74369.1 - 6.4e-15 55.0 2.1 1.5e-14 53.8 2.1 1.7 1 0 0 1 1 1 1 RAP domain MTES_1575 PF18741.1 EKX74369.1 - 4e-08 33.3 0.2 9e-08 32.2 0.0 1.7 2 0 0 2 2 2 1 REase_MTES_1575 DUF559 PF04480.12 EKX74369.1 - 0.00098 19.0 0.0 0.0027 17.6 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF559) TetR PF13972.6 EKX74369.1 - 0.0049 16.6 0.0 0.013 15.2 0.0 1.7 1 0 0 1 1 1 1 Bacterial transcriptional repressor FAST_1 PF06743.15 EKX74369.1 - 0.14 12.1 3.6 0.15 12.0 0.1 2.9 3 0 0 3 3 3 0 FAST kinase-like protein, subdomain 1 Myb_Cef PF11831.8 EKX74370.1 - 5.1e-27 95.0 5.5 5.1e-27 95.0 5.5 2.6 3 0 0 3 3 3 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 EKX74370.1 - 9.4e-21 73.8 6.9 3e-10 40.1 1.1 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EKX74370.1 - 2e-16 59.9 5.8 1.2e-10 41.5 2.7 3.1 1 1 1 2 2 2 2 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 EKX74370.1 - 0.013 15.7 1.8 0.046 13.9 0.8 2.6 2 1 0 2 2 2 0 SANT/Myb-like domain of DAMP1 Hormone_2 PF00123.20 EKX74370.1 - 0.063 13.2 0.1 1.2 9.1 0.0 2.9 2 0 0 2 2 2 0 Peptide hormone Ras PF00071.22 EKX74372.1 - 8e-57 191.4 0.3 9.8e-57 191.1 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKX74372.1 - 1.6e-34 118.7 0.2 2.2e-34 118.2 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKX74372.1 - 1.6e-13 50.5 0.0 2.1e-13 50.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKX74372.1 - 9.6e-08 32.1 0.1 1.5e-07 31.5 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKX74372.1 - 2.9e-06 27.0 0.0 0.00021 20.9 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EKX74372.1 - 0.00011 21.7 0.0 0.00025 20.5 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EKX74372.1 - 0.00027 20.9 0.4 0.7 9.8 0.0 2.1 1 1 1 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EKX74372.1 - 0.0015 18.0 0.0 0.002 17.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_24 PF13479.6 EKX74372.1 - 0.023 14.4 0.1 0.75 9.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.18 EKX74372.1 - 0.026 14.0 0.3 0.065 12.8 0.3 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B TniB PF05621.11 EKX74372.1 - 0.096 12.1 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA_21 PF13304.6 EKX74372.1 - 0.11 12.3 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_14 PF13173.6 EKX74372.1 - 0.11 12.6 0.1 0.27 11.3 0.1 1.7 1 1 0 1 1 1 0 AAA domain Ribosomal_S8 PF00410.19 EKX74373.1 - 1.2e-17 64.1 0.0 1.3e-17 63.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S8 MA3 PF02847.17 EKX74374.1 - 3.2e-17 62.5 1.1 3.2e-17 62.5 1.1 1.9 2 0 0 2 2 2 1 MA3 domain MIF4G PF02854.19 EKX74374.1 - 4.1e-13 49.5 1.1 6.8e-13 48.7 0.0 1.9 2 0 0 2 2 2 1 MIF4G domain DUF5523 PF17661.1 EKX74374.1 - 0.00078 19.2 0.4 0.00078 19.2 0.4 1.7 2 0 0 2 2 2 1 Family of unknown function (DUF5523) Cnd1 PF12717.7 EKX74374.1 - 0.0015 18.6 0.2 0.0038 17.3 0.2 1.6 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 RRM_1 PF00076.22 EKX74375.1 - 8.2e-34 115.3 0.1 1.9e-16 59.6 0.0 2.4 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WW PF00397.26 EKX74375.1 - 2.9e-09 36.8 3.3 5.9e-09 35.9 3.3 1.5 1 0 0 1 1 1 1 WW domain RRM_7 PF16367.5 EKX74375.1 - 4.1e-07 30.0 0.1 6.8e-05 22.9 0.0 2.8 2 2 0 2 2 2 1 RNA recognition motif Nup35_RRM PF05172.13 EKX74375.1 - 0.00017 21.5 0.2 0.056 13.4 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RNA_bind PF08675.11 EKX74375.1 - 0.0011 19.0 0.4 0.025 14.6 0.2 2.8 2 1 0 2 2 2 1 RNA binding domain Nup35_RRM_2 PF14605.6 EKX74375.1 - 0.0027 17.7 0.0 0.86 9.7 0.0 2.4 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif DUF1866 PF08952.11 EKX74375.1 - 0.0033 17.3 0.0 1.2 9.0 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF1866) BRAP2 PF07576.12 EKX74375.1 - 0.0079 16.4 0.0 0.7 10.2 0.0 2.2 2 0 0 2 2 2 1 BRCA1-associated protein 2 RRM_occluded PF16842.5 EKX74375.1 - 0.046 13.6 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Occluded RNA-recognition motif RRM_2 PF04059.12 EKX74375.1 - 0.067 13.4 0.1 0.47 10.7 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif 2 RL PF17797.1 EKX74375.1 - 0.13 12.2 0.0 0.5 10.4 0.0 1.8 2 0 0 2 2 2 0 RL domain PHM7_cyt PF14703.6 EKX74375.1 - 0.14 12.4 0.3 2.4 8.4 0.1 2.8 2 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter PDEase_I PF00233.19 EKX74377.1 - 1.7e-70 237.5 0.1 2.6e-70 236.9 0.1 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 EKX74377.1 - 0.00019 21.6 0.1 0.00043 20.5 0.1 1.7 1 1 0 1 1 1 1 HD domain Exo_endo_phos PF03372.23 EKX74378.1 - 3.6e-07 29.9 0.0 1.9e-06 27.6 0.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SpoIISA_toxin PF14171.6 EKX74380.1 - 0.006 16.3 0.5 0.014 15.1 0.1 1.9 2 0 0 2 2 2 1 Toxin SpoIISA, type II toxin-antitoxin system Ribonuc_red_sm PF00268.21 EKX74382.1 - 3e-51 174.6 3.9 5.2e-51 173.8 3.9 1.4 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain EMP24_GP25L PF01105.24 EKX74383.1 - 3.1e-22 79.4 0.0 3.8e-22 79.1 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD TBCC PF07986.12 EKX74384.1 - 2.1e-27 95.3 0.4 3.8e-27 94.4 0.4 1.5 1 0 0 1 1 1 1 Tubulin binding cofactor C Pinin_SDK_memA PF04696.13 EKX74385.1 - 1.6e-19 70.3 11.5 1.6e-19 70.3 11.5 1.7 2 0 0 2 2 2 1 pinin/SDK/memA/ protein conserved region DUF5082 PF16888.5 EKX74385.1 - 0.37 11.1 19.4 0.88 9.9 0.8 2.9 1 1 0 2 2 2 0 Domain of unknown function (DUF5082) Prefoldin_2 PF01920.20 EKX74385.1 - 0.38 10.7 17.0 4 7.4 12.1 2.6 2 0 0 2 2 2 0 Prefoldin subunit DUF2536 PF10750.9 EKX74385.1 - 0.81 9.6 9.0 12 5.8 0.1 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2536) THOC7 PF05615.13 EKX74385.1 - 0.89 9.8 13.1 11 6.3 12.9 2.4 1 1 0 1 1 1 0 Tho complex subunit 7 EMC3_TMCO1 PF01956.16 EKX74385.1 - 1.2 8.9 4.5 2.1 8.1 4.5 1.6 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like RRF_GI PF12614.8 EKX74385.1 - 1.5 9.0 7.3 4.5 7.4 4.6 2.7 2 1 1 3 3 3 0 Ribosome recycling factor Med9 PF07544.13 EKX74385.1 - 1.6 8.8 18.3 15 5.8 0.1 2.7 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF1788 PF08747.11 EKX74385.1 - 7.2 6.6 7.1 37 4.4 4.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1788) BPL_LplA_LipB PF03099.19 EKX74386.1 - 6.8e-08 32.5 0.0 6.5e-07 29.3 0.0 2.1 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Lip_prot_lig_C PF10437.9 EKX74386.1 - 1.3e-07 31.5 0.7 3.2e-07 30.2 0.1 2.0 2 0 0 2 2 2 1 Bacterial lipoate protein ligase C-terminus DUF4883 PF16224.5 EKX74386.1 - 0.0021 18.3 0.6 0.0021 18.3 0.6 2.2 2 1 0 2 2 2 1 DOmain of unknown function (DUF4883) CheR PF01739.18 EKX74386.1 - 0.082 12.4 0.2 0.39 10.2 0.1 1.9 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain DUF4720 PF15846.5 EKX74386.1 - 0.11 12.4 0.3 1.9 8.4 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4720) RCC1_2 PF13540.6 EKX74387.1 - 6.3e-28 96.0 17.8 3.7e-08 33.0 0.1 6.0 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EKX74387.1 - 1.4e-23 83.3 1.2 1.2e-07 32.3 0.0 7.6 8 1 0 8 8 8 3 Regulator of chromosome condensation (RCC1) repeat SBBP PF06739.11 EKX74387.1 - 0.012 15.6 5.9 0.09 12.8 1.3 2.6 2 0 0 2 2 2 0 Beta-propeller repeat CWC25 PF12542.8 EKX74388.1 - 2e-11 44.7 0.1 2e-11 44.7 0.1 4.2 3 2 0 3 3 3 1 Pre-mRNA splicing factor CKS PF01111.19 EKX74389.1 - 2.1e-18 66.4 0.0 2.8e-18 65.9 0.0 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit GTP_EFTU PF00009.27 EKX74390.1 - 7.4e-23 81.1 1.8 1.6e-20 73.4 1.8 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EKX74390.1 - 7.2e-13 48.6 0.0 1.3e-11 44.5 0.0 2.4 2 0 0 2 2 2 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 EKX74390.1 - 1.6e-05 24.9 0.0 3.4e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EKX74390.1 - 4.9e-05 23.4 0.3 0.00038 20.6 0.0 2.4 2 1 1 3 3 3 1 Dynamin family SRPRB PF09439.10 EKX74390.1 - 0.00049 19.6 0.0 0.00087 18.8 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EKX74390.1 - 0.00087 19.0 0.1 0.042 13.6 0.1 2.9 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 EKX74390.1 - 0.0012 18.8 0.1 0.4 10.6 0.0 2.4 1 1 1 2 2 2 2 RsgA GTPase MMR_HSR1_Xtn PF16897.5 EKX74390.1 - 0.021 14.8 0.3 0.093 12.8 0.3 2.0 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain DUF2753 PF10952.8 EKX74390.1 - 0.062 13.4 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2753) Ras PF00071.22 EKX74390.1 - 0.067 12.8 0.0 0.19 11.3 0.0 1.7 1 1 0 1 1 1 0 Ras family Roc PF08477.13 EKX74390.1 - 0.081 13.2 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase zf-B_box PF00643.24 EKX74391.1 - 1.2e-10 41.3 14.9 4.3e-07 30.0 3.9 2.5 2 0 0 2 2 2 2 B-box zinc finger PH PF00169.29 EKX74391.1 - 4.8e-07 30.3 0.7 1.1e-06 29.1 0.2 1.9 2 0 0 2 2 2 1 PH domain Baculo_PEP_C PF04513.12 EKX74391.1 - 0.032 14.3 7.6 1.5 8.9 0.2 3.0 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus zf-UBR PF02207.20 EKX74391.1 - 2.8 8.2 12.6 0.071 13.3 2.2 2.7 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) zf-C4pol PF14260.6 EKX74391.1 - 6.9 7.2 9.1 1.1 9.7 0.6 3.4 2 0 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta CLASP_N PF12348.8 EKX74392.1 - 5.7e-06 26.1 2.4 0.00016 21.3 0.3 2.1 1 1 1 2 2 2 2 CLASP N terminal Mo25 PF08569.11 EKX74392.1 - 0.002 17.6 1.5 0.0024 17.3 1.5 1.3 1 0 0 1 1 1 1 Mo25-like DUF29 PF01724.16 EKX74392.1 - 0.011 16.0 0.4 0.023 14.9 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF29 FAINT PF04385.15 EKX74393.1 - 1.7e-05 24.8 0.1 2.4e-05 24.3 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 EKX74394.1 - 2e-07 30.9 0.0 3.4e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function, DUF529 FAINT PF04385.15 EKX74397.1 - 2.1e-17 62.9 0.1 0.00016 21.7 0.0 5.4 4 2 1 5 5 5 3 Domain of unknown function, DUF529 Insulin_TMD PF17870.1 EKX74398.1 - 1.3 9.1 4.5 0.88 9.7 1.2 2.3 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment Atracotoxin PF05353.11 EKX74398.1 - 6.3 6.9 8.9 0.18 11.9 1.9 2.1 2 0 0 2 2 2 0 Delta Atracotoxin MFS_1 PF07690.16 EKX74402.1 - 3.3e-16 59.2 38.0 8.6e-16 57.8 35.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3007 PF11460.8 EKX74402.1 - 0.13 12.6 0.7 0.48 10.7 0.7 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3007) MHCassoc_trimer PF08831.10 EKX74404.1 - 0.16 12.0 0.0 0.49 10.5 0.0 1.7 1 0 0 1 1 1 0 Class II MHC-associated invariant chain trimerisation domain ThiF PF00899.21 EKX74405.1 - 5.5e-09 35.8 0.0 9.4e-09 35.0 0.0 1.3 1 0 0 1 1 1 1 ThiF family DUF4234 PF14018.6 EKX74405.1 - 0.026 14.6 0.0 0.091 12.9 0.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4234) BBS2_Mid PF14783.6 EKX74405.1 - 0.031 14.3 0.6 14 5.8 0.0 3.3 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region TSCPD PF12637.7 EKX74405.1 - 0.062 13.5 0.1 0.18 12.0 0.1 1.7 1 0 0 1 1 1 0 TSCPD domain Pkinase PF00069.25 EKX74406.1 - 9e-55 185.9 0.5 1.5e-54 185.2 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKX74406.1 - 1.7e-27 96.4 0.0 3e-26 92.3 0.0 2.4 2 1 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EKX74406.1 - 0.00035 20.6 0.0 0.042 13.8 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EKX74406.1 - 0.0021 17.4 0.0 0.042 13.2 0.0 2.2 2 0 0 2 2 2 1 Kinase-like DUF5305 PF17231.2 EKX74406.1 - 0.0084 15.5 2.1 0.014 14.8 2.1 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5305) LIDHydrolase PF10230.9 EKX74406.1 - 0.024 14.2 1.8 0.038 13.5 1.8 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Troponin PF00992.20 EKX74406.1 - 0.13 12.6 4.5 0.27 11.5 4.5 1.5 1 0 0 1 1 1 0 Troponin PH PF00169.29 EKX74407.1 - 0.037 14.5 0.1 0.052 14.1 0.1 1.5 1 1 0 1 1 1 0 PH domain CBFD_NFYB_HMF PF00808.23 EKX74409.1 - 6.3e-23 80.8 0.0 9.8e-23 80.2 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EKX74409.1 - 0.00018 21.8 0.0 0.00029 21.2 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID_20kDa PF03847.13 EKX74409.1 - 0.016 15.7 0.0 0.034 14.6 0.0 1.5 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A CENP-T_C PF15511.6 EKX74409.1 - 0.02 15.0 0.0 0.038 14.1 0.0 1.5 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold Bromo_TP PF07524.13 EKX74409.1 - 0.024 14.6 0.0 0.069 13.2 0.0 1.8 1 1 1 2 2 2 0 Bromodomain associated Peptidase_C13 PF01650.18 EKX74411.1 - 3.4e-07 30.1 0.7 9.8e-07 28.5 0.7 1.7 1 1 0 1 1 1 1 Peptidase C13 family GH115_C PF17829.1 EKX74411.1 - 0.069 13.0 0.8 0.13 12.1 0.8 1.3 1 0 0 1 1 1 0 Gylcosyl hydrolase family 115 C-terminal domain DUF1548 PF07579.11 EKX74411.1 - 1.1 9.6 4.8 0.37 11.1 0.3 2.5 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1548) Lectin_like PF18560.1 EKX74412.1 - 0.043 14.0 0.3 0.14 12.3 0.0 1.9 2 0 0 2 2 2 0 Lectin like domain ParA PF10609.9 EKX74413.1 - 1.9e-63 214.2 0.2 5.6e-43 147.2 0.0 2.1 2 0 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EKX74413.1 - 5.9e-10 39.3 0.0 8.2e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EKX74413.1 - 1.6e-08 34.7 0.6 1.2e-07 31.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain ArsA_ATPase PF02374.15 EKX74413.1 - 7.2e-06 25.4 0.3 0.00028 20.2 0.1 2.4 2 1 0 2 2 2 1 Anion-transporting ATPase MipZ PF09140.11 EKX74413.1 - 0.00034 20.0 0.0 0.0019 17.5 0.0 2.0 2 0 0 2 2 2 1 ATPase MipZ CBP_BcsQ PF06564.12 EKX74413.1 - 0.04 13.4 0.1 0.29 10.6 0.0 2.0 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ Choline_kinase PF01633.20 EKX74414.1 - 3.1e-34 118.4 0.0 4.7e-34 117.8 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EKX74414.1 - 3.3e-05 23.9 0.0 5e-05 23.3 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family FixS PF03597.15 EKX74415.1 - 0.036 13.8 1.6 0.067 12.9 1.6 1.3 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type Ribosomal_S7 PF00177.21 EKX74416.1 - 5.7e-39 133.1 1.4 7.3e-39 132.8 1.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Arf PF00025.21 EKX74417.1 - 2e-14 53.4 0.0 2.1e-14 53.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EKX74417.1 - 2.2e-06 27.9 0.0 3.6e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EKX74417.1 - 8.3e-06 25.3 0.0 9.5e-06 25.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EKX74417.1 - 2.5e-05 23.8 0.0 2.9e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EKX74417.1 - 0.00017 21.2 0.0 0.00022 20.9 0.0 1.1 1 0 0 1 1 1 1 Ras family AAA_16 PF13191.6 EKX74417.1 - 0.036 14.5 0.0 0.083 13.3 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_14 PF13173.6 EKX74417.1 - 0.12 12.4 0.0 0.28 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain TFIIF_beta_N PF17683.1 EKX74418.1 - 0.0027 18.4 0.8 0.0047 17.6 0.6 1.8 1 1 0 1 1 1 1 TFIIF, beta subunit N-terminus MBF1 PF08523.10 EKX74419.1 - 1.2e-18 67.3 0.4 1.2e-18 67.3 0.4 1.9 2 0 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 EKX74419.1 - 1.1e-12 47.8 0.1 1.8e-12 47.1 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 EKX74419.1 - 3.5e-07 30.5 0.0 9e-07 29.2 0.0 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_19 PF12844.7 EKX74419.1 - 3.9e-05 23.6 0.3 8e-05 22.6 0.3 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 EKX74419.1 - 0.0048 17.3 0.0 0.0076 16.7 0.0 1.3 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain DUF5530 PF17670.1 EKX74419.1 - 0.092 12.5 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5530) DUF5315 PF17242.2 EKX74419.1 - 0.094 12.6 0.1 1.1 9.1 0.1 2.2 2 0 0 2 2 2 0 Disordered region of unknown function (DUF5315) polyprenyl_synt PF00348.17 EKX74420.1 - 1.6e-71 240.4 0.5 1.9e-71 240.1 0.5 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase CD20 PF04103.15 EKX74422.1 - 0.27 11.3 6.5 0.2 11.7 0.3 2.1 2 0 0 2 2 2 0 CD20-like family PGF-CTERM PF18204.1 EKX74422.1 - 5.2 7.2 7.9 0.32 11.0 1.8 2.3 2 0 0 2 2 2 0 PGF-CTERM motif AP2 PF00847.20 EKX74423.1 - 1.4e-11 44.4 3.4 2.7e-11 43.5 3.4 1.5 1 0 0 1 1 1 1 AP2 domain vATP-synt_E PF01991.18 EKX74424.1 - 1e-35 123.0 10.4 1.2e-35 122.7 10.4 1.1 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit DUF2710 PF10921.8 EKX74424.1 - 0.0039 17.6 1.8 0.007 16.8 0.3 2.2 2 1 2 4 4 4 1 Protein of unknown function (DUF2710) BLOC1S3 PF15753.5 EKX74424.1 - 0.0086 16.2 5.6 0.017 15.3 2.9 2.0 2 0 0 2 2 2 1 Biogenesis of lysosome-related organelles complex 1 subunit 3 IL32 PF15225.6 EKX74424.1 - 0.011 16.1 0.9 0.047 14.1 0.1 2.2 2 0 0 2 2 2 0 Interleukin 32 Dehydratase_SU PF02287.15 EKX74424.1 - 0.029 14.5 0.5 0.029 14.5 0.5 2.1 2 0 0 2 2 2 0 Dehydratase small subunit Med26 PF08711.11 EKX74424.1 - 0.03 14.3 0.6 0.47 10.5 0.5 2.4 2 0 0 2 2 2 0 TFIIS helical bundle-like domain Peptidase_C41 PF05417.11 EKX74424.1 - 0.056 13.3 0.1 0.088 12.6 0.1 1.3 1 0 0 1 1 1 0 Hepatitis E cysteine protease CheR_N PF03705.15 EKX74424.1 - 0.089 12.5 0.7 0.67 9.7 0.2 2.4 2 0 0 2 2 2 0 CheR methyltransferase, all-alpha domain DUF4047 PF13256.6 EKX74424.1 - 0.46 10.7 8.3 4.9 7.4 0.2 2.6 1 1 0 2 2 2 0 Domain of unknown function (DUF4047) DivIVA PF05103.13 EKX74424.1 - 3.5 7.7 12.6 0.52 10.4 0.2 3.1 2 1 0 2 2 2 0 DivIVA protein SecY PF00344.20 EKX74425.1 - 2.5e-69 233.9 12.0 2.5e-69 233.9 12.0 1.3 2 0 0 2 2 2 1 SecY translocase Plug_translocon PF10559.9 EKX74425.1 - 3.9e-17 61.8 1.8 7.8e-17 60.8 0.1 2.5 2 0 0 2 2 2 1 Plug domain of Sec61p Mog1 PF04603.12 EKX74426.1 - 9.2e-21 74.7 0.0 1.3e-20 74.2 0.0 1.2 1 0 0 1 1 1 1 Ran-interacting Mog1 protein Spindle_Spc25 PF08234.12 EKX74427.1 - 2.8e-17 62.7 0.0 6e-17 61.6 0.0 1.6 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 Cofilin_ADF PF00241.20 EKX74427.1 - 0.0018 18.1 0.3 1 9.2 0.0 3.0 2 1 1 3 3 3 1 Cofilin/tropomyosin-type actin-binding protein RasGAP_C PF03836.15 EKX74427.1 - 0.0088 16.2 3.9 0.026 14.7 3.9 1.7 1 1 0 1 1 1 1 RasGAP C-terminus Uso1_p115_C PF04871.13 EKX74427.1 - 0.013 15.9 1.8 0.019 15.3 1.8 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Golgin_A5 PF09787.9 EKX74427.1 - 0.043 13.3 2.6 0.059 12.8 2.6 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 Cep57_CLD_2 PF14197.6 EKX74427.1 - 0.056 13.5 1.7 0.085 13.0 0.6 1.8 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 TPR_MLP1_2 PF07926.12 EKX74427.1 - 0.056 13.5 4.2 0.097 12.7 4.2 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF4200 PF13863.6 EKX74427.1 - 0.09 13.2 7.7 0.36 11.3 6.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF4140 PF13600.6 EKX74427.1 - 0.16 12.4 5.0 3.9 8.0 1.4 2.3 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) KELK PF15796.5 EKX74427.1 - 0.3 11.6 4.6 3.2 8.3 2.6 2.4 1 1 1 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase THOC7 PF05615.13 EKX74427.1 - 0.76 10.1 7.1 0.49 10.7 0.9 2.2 1 1 1 2 2 2 0 Tho complex subunit 7 DUF1664 PF07889.12 EKX74427.1 - 0.76 9.8 3.3 1.5 8.8 3.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) HIT PF01230.23 EKX74430.1 - 7.6e-26 90.7 0.1 9.5e-26 90.4 0.1 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EKX74430.1 - 1.5e-20 73.8 0.4 1.9e-20 73.4 0.4 1.0 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Babesia_equi-strainWA-JCVI-bewag-v1.1/GCA_000342415.1_JCVI-bewag-v1.1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Babesia_equi-strainWA-JCVI-bewag-v1.1/GCA_000342415.1_JCVI-bewag-v1.1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Babesia_equi-strainWA-JCVI-bewag-v1.1/GCA_000342415.1_JCVI-bewag-v1.1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Babesia_equi-strainWA-JCVI-bewag-v1.1/GCA_000342415.1_JCVI-bewag-v1.1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 00:36:48 2019 # [ok]