# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- COX1 PF00115.20 ABU97452.1 - 1.7e-108 363.3 57.7 1.9e-108 363.1 57.7 1.0 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I zf-CHCC PF10276.9 ABU97452.1 - 0.16 12.0 0.5 0.51 10.4 0.5 1.8 1 1 0 1 1 1 0 Zinc-finger domain COX3 PF00510.18 ABU97453.1 - 1.1e-09 38.5 20.3 5.9e-09 36.1 20.3 2.0 1 1 0 1 1 1 1 Cytochrome c oxidase subunit III DUF1230 PF06799.11 ABU97453.1 - 0.17 12.0 1.9 0.19 11.8 0.3 1.9 2 0 0 2 2 2 0 Conserved in the green lineage and diatoms 27 Cytochrome_B PF00033.19 ABU97454.1 - 1.4e-46 158.7 25.5 1.4e-46 158.7 25.5 1.7 2 0 0 2 2 2 1 Cytochrome b/b6/petB Cytochrom_B_N_2 PF13631.6 ABU97454.1 - 1.9e-21 76.8 16.5 2.7e-21 76.3 12.2 2.3 2 0 0 2 2 2 1 Cytochrome b(N-terminal)/b6/petB Cytochrom_B_C PF00032.17 ABU97454.1 - 1.2e-17 64.0 2.3 1.2e-17 64.0 2.3 3.0 2 1 1 3 3 3 1 Cytochrome b(C-terminal)/b6/petD DUF3619 PF12279.8 ABU97454.1 - 0.11 12.9 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3619) OHCU_decarbox PF09349.10 EDO05048.1 - 1.3 9.5 6.1 8.1 6.9 0.2 2.7 2 0 0 2 2 2 0 OHCU decarboxylase VESA1_N PF12785.7 EDO05049.1 - 4.9e-16 58.8 2.2 3.1e-11 42.9 0.1 4.1 3 1 1 4 4 4 3 Variant erythrocyte surface antigen-1 Sporozoite_P67 PF05642.11 EDO05049.1 - 0.085 10.9 0.1 0.13 10.3 0.1 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2510 PF10708.9 EDO05049.1 - 1.6 8.5 4.0 5.1 6.9 0.4 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2510) VESA1_N PF12785.7 EDO05050.1 - 2.4e-175 583.9 25.1 4.4e-104 349.0 3.9 2.0 1 1 1 2 2 2 2 Variant erythrocyte surface antigen-1 DDE_Tnp_1_assoc PF13808.6 EDO05050.1 - 0.0024 17.9 0.0 0.005 16.8 0.0 1.4 1 0 0 1 1 1 1 DDE_Tnp_1-associated VESA1_N PF12785.7 EDO05051.1 - 3.4e-224 744.9 17.9 3.4e-224 744.9 17.9 2.1 2 0 0 2 2 2 1 Variant erythrocyte surface antigen-1 DUF5104 PF17117.5 EDO05051.1 - 0.032 14.7 0.2 0.12 12.8 0.2 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF5104) Apolipoprotein PF01442.18 EDO05051.1 - 0.076 12.9 2.7 0.12 12.3 1.5 1.6 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain DUF4795 PF16043.5 EDO05051.1 - 0.085 12.4 2.3 0.45 10.1 1.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) Baculo_PEP_C PF04513.12 EDO05051.1 - 0.15 12.1 1.1 4.1 7.4 0.1 2.8 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Prefoldin_2 PF01920.20 EDO05051.1 - 0.26 11.2 7.8 0.056 13.4 1.9 2.5 2 1 1 3 3 3 0 Prefoldin subunit CdvA PF18822.1 EDO05051.1 - 0.27 11.1 3.7 3.5 7.5 1.3 2.6 2 0 0 2 2 2 0 CdvA-like coiled-coil domain VESA1_N PF12785.7 EDO05052.1 - 1.2e-13 50.9 12.8 4.1e-09 35.9 0.8 6.2 3 1 2 6 6 6 3 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO05054.1 - 1.9e-20 73.3 17.2 1.1e-16 60.9 12.6 3.1 1 1 1 2 2 2 2 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO05055.1 - 1.5e-221 736.2 22.0 1.5e-221 736.2 22.0 2.8 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO05057.1 - 6.1e-27 94.7 20.7 7.5e-26 91.1 13.8 4.9 3 2 1 4 4 4 2 Variant erythrocyte surface antigen-1 DUF5638 PF18688.1 EDO05057.1 - 0.17 12.2 0.1 0.36 11.2 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5638) DUF2510 PF10708.9 EDO05057.1 - 1.1 9.1 3.4 0.52 10.1 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2510) VESA1_N PF12785.7 EDO05058.1 - 1.2e-229 762.9 18.5 1.2e-229 762.9 18.5 2.4 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 DUF3439 PF11921.8 EDO05058.1 - 0.04 13.9 8.9 0.12 12.4 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3439) FliS PF02561.14 EDO05058.1 - 9.4 6.5 6.0 3.2 8.1 0.2 2.7 3 0 0 3 3 3 0 Flagellar protein FliS VESA1_N PF12785.7 EDO05060.1 - 4.1e-21 75.5 27.8 3.2e-12 46.2 0.1 4.0 1 1 2 3 3 3 2 Variant erythrocyte surface antigen-1 CBF_beta PF02312.17 EDO05060.1 - 0.13 11.9 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 Core binding factor beta subunit VESA1_N PF12785.7 EDO05061.1 - 7.5e-228 757.0 19.7 7.5e-228 757.0 19.7 2.5 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 Spc7 PF08317.11 EDO05061.1 - 0.12 11.2 2.1 0.95 8.3 0.0 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein YlqD PF11068.8 EDO05061.1 - 6.8 7.1 5.5 9.1 6.7 0.3 2.4 1 1 1 2 2 2 0 YlqD protein VESA1_N PF12785.7 EDO05062.1 - 1.3e-17 63.9 27.1 2.8e-10 39.8 0.0 4.4 3 1 1 4 4 4 3 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO05063.1 - 2e-217 722.6 18.9 2e-217 722.6 18.9 2.6 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 Ribosomal_S2 PF00318.20 EDO05064.1 - 4.3e-32 111.1 11.4 5e-32 110.9 11.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S2 SLATT_1 PF18181.1 EDO05065.1 - 0.035 14.0 0.1 0.066 13.1 0.1 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 RNA_pol_Rpb1_5 PF04998.17 EDO05066.1 - 5.1e-24 85.1 0.0 8.1e-24 84.5 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EDO05067.1 - 2.5e-26 92.9 0.1 7e-26 91.4 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_1 PF04997.12 EDO05067.1 - 0.3 10.4 15.5 0.4 10.0 1.0 3.9 2 1 0 3 3 3 0 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb2_6 PF00562.28 EDO05068.1 - 2.7e-37 128.8 5.1 2.7e-37 128.8 5.1 2.3 2 1 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 PF04560.20 EDO05068.1 - 4.6e-09 36.6 0.1 3.7e-08 33.7 0.1 2.7 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 EDO05068.1 - 0.0062 16.7 0.0 0.013 15.6 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 AAA_2 PF07724.14 EDO05070.1 - 2e-38 132.2 0.0 7.4e-38 130.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 EDO05070.1 - 3.2e-11 43.8 0.3 3.1e-07 30.9 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EDO05070.1 - 2.7e-08 33.9 0.0 6.8e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EDO05070.1 - 7.1e-07 29.1 0.0 1.2e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_7 PF12775.7 EDO05070.1 - 2e-05 24.2 0.4 0.00016 21.2 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region Mg_chelatase PF01078.21 EDO05070.1 - 0.0041 16.5 0.1 0.46 9.8 0.0 2.3 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 EDO05070.1 - 0.011 15.0 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin RuvB_N PF05496.12 EDO05070.1 - 0.026 14.3 0.9 0.79 9.5 0.0 3.1 3 1 1 4 4 4 0 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EDO05070.1 - 0.029 14.6 0.1 0.16 12.3 0.1 2.2 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDO05070.1 - 0.048 14.0 0.7 0.048 14.0 0.7 3.2 3 2 1 4 4 4 0 RNA helicase TFIID-18kDa PF02269.16 EDO05070.1 - 0.061 13.4 0.3 0.19 11.8 0.3 1.9 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit ABC_tran PF00005.27 EDO05070.1 - 0.078 13.5 0.0 0.21 12.1 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_3 PF07726.11 EDO05070.1 - 0.093 12.6 0.1 0.3 11.0 0.0 1.9 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Serum_albumin PF00273.20 EDO05070.1 - 0.13 12.1 1.0 0.36 10.6 0.1 2.3 2 1 1 3 3 3 0 Serum albumin family AAA_33 PF13671.6 EDO05070.1 - 0.22 11.7 0.0 0.58 10.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 EDO05071.1 - 1.8e-40 138.9 0.1 4.7e-40 137.5 0.0 1.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EDO05071.1 - 2.5e-09 37.2 0.0 1.2e-08 35.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 EDO05071.1 - 2.9e-07 31.0 0.0 8.8e-07 29.4 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EDO05071.1 - 6.1e-07 29.3 0.0 1.3e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_7 PF12775.7 EDO05071.1 - 4.3e-06 26.3 0.2 1.8e-05 24.3 0.1 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region Torsin PF06309.11 EDO05071.1 - 0.0044 17.1 0.0 0.015 15.4 0.0 2.0 1 0 0 1 1 1 1 Torsin Zeta_toxin PF06414.12 EDO05071.1 - 0.0079 15.5 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.6 EDO05071.1 - 0.013 15.7 0.7 0.082 13.2 0.2 2.5 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EDO05071.1 - 0.022 15.2 0.0 0.056 13.8 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.27 EDO05071.1 - 0.022 15.3 0.5 0.044 14.3 0.5 1.7 1 1 0 1 1 1 0 ABC transporter DUF815 PF05673.13 EDO05071.1 - 0.028 13.6 0.1 0.31 10.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) DUF2153 PF09921.9 EDO05071.1 - 0.07 12.9 0.0 0.31 10.9 0.0 2.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2153) DUF87 PF01935.17 EDO05071.1 - 0.12 12.5 9.6 0.057 13.5 2.7 3.3 3 1 0 3 3 3 0 Helicase HerA, central domain NTPase_1 PF03266.15 EDO05071.1 - 0.12 12.3 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 NTPase AAA_18 PF13238.6 EDO05071.1 - 0.15 12.6 0.3 0.76 10.3 0.0 2.4 3 0 0 3 3 2 0 AAA domain T2SSE PF00437.20 EDO05071.1 - 0.2 10.7 0.0 0.32 10.0 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF2533 PF10752.9 EDO05071.1 - 0.71 10.4 3.5 11 6.6 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2533) DHHC PF01529.20 EDO05072.1 - 0.28 11.3 4.8 0.38 10.9 4.8 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase GTP_EFTU PF00009.27 EDO05077.1 - 2.1e-53 180.8 0.6 3e-53 180.3 0.6 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EDO05077.1 - 6.4e-24 84.4 0.0 1.3e-23 83.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EDO05077.1 - 7.4e-13 48.7 0.6 5.9e-12 45.8 0.8 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDO05077.1 - 4.3e-05 23.6 0.1 8.8e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 EDO05077.1 - 0.0085 16.0 1.5 0.028 14.3 0.3 2.5 3 0 0 3 3 3 1 Elongation factor Tu domain 4 RsgA_GTPase PF03193.16 EDO05077.1 - 0.015 15.2 1.1 0.052 13.4 0.1 2.2 2 1 1 3 3 3 0 RsgA GTPase ExoD PF06055.12 EDO05078.1 - 0.0081 15.6 0.3 0.0099 15.3 0.3 1.1 1 0 0 1 1 1 1 Exopolysaccharide synthesis, ExoD Caveolin PF01146.17 EDO05078.1 - 0.16 11.9 3.2 0.19 11.7 2.4 1.5 1 1 0 1 1 1 0 Caveolin Vac14_Fab1_bd PF12755.7 EDO05079.1 - 0.23 12.1 4.1 7.1 7.3 0.7 2.2 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region DUF2639 PF11121.8 EDO05080.1 - 0.036 14.1 1.6 0.062 13.3 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2639) DUF2639 PF11121.8 EDO05081.1 - 0.036 14.1 1.6 0.062 13.3 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2639) DUF2639 PF11121.8 EDO05082.1 - 0.036 14.1 1.6 0.062 13.3 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2639) Ribosom_S12_S23 PF00164.25 EDO05084.1 - 5.4e-23 80.8 5.8 6.3e-23 80.6 5.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Ribosomal_S12 PF17487.2 EDO05084.1 - 0.011 16.5 0.0 0.016 15.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein S12 Ribosomal_S8 PF00410.19 EDO05088.1 - 2.3e-10 40.5 0.3 2.6e-10 40.3 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S8 DUF4866 PF16160.5 EDO05088.1 - 0.0018 17.7 0.6 0.002 17.5 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4866) Ribosomal_L14 PF00238.19 EDO05090.1 - 4.1e-10 39.8 0.5 4.4e-10 39.7 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e PRD PF00874.20 EDO05090.1 - 0.068 13.5 0.7 0.12 12.7 0.7 1.3 1 0 0 1 1 1 0 PRD domain Ribosomal_L16 PF00252.18 EDO05091.1 - 2.4e-31 108.5 0.0 2.7e-31 108.3 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Ribosomal_S3_C PF00189.20 EDO05092.1 - 5.2e-10 39.7 0.3 8.2e-10 39.1 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein S3, C-terminal domain Ribosomal_L2_C PF03947.18 EDO05093.1 - 2.7e-30 105.2 0.0 3.7e-30 104.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EDO05093.1 - 0.00017 21.5 1.1 0.00017 21.5 1.1 1.9 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain DUF4283 PF14111.6 EDO05094.1 - 0.055 13.0 0.0 0.11 12.0 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4283) S4 PF01479.25 EDO05095.1 - 2e-06 27.4 0.0 4.9e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 S4 domain Lipase PF00151.19 EDO05095.1 - 0.052 12.8 0.8 0.07 12.4 0.8 1.1 1 0 0 1 1 1 0 Lipase VESA1_N PF12785.7 EDO05096.1 - 6.8e-19 68.2 10.9 6.8e-19 68.2 10.9 5.3 3 1 1 4 4 4 2 Variant erythrocyte surface antigen-1 DUF5638 PF18688.1 EDO05096.1 - 0.27 11.6 0.7 2.1 8.7 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5638) VESA1_N PF12785.7 EDO05097.1 - 1.5e-228 759.3 17.5 1.5e-228 759.3 17.5 2.5 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 MnmE_helical PF12631.7 EDO05097.1 - 0.062 13.5 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 MnmE helical domain ApoLp-III PF07464.11 EDO05097.1 - 0.41 10.7 5.1 0.94 9.6 5.1 1.6 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) CC2-LZ PF16516.5 EDO05097.1 - 1.6 9.2 5.2 3.8 7.9 5.2 1.7 1 0 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator CdvA PF18822.1 EDO05097.1 - 2.4 8.0 6.9 11 5.9 5.8 2.4 2 0 0 2 2 2 0 CdvA-like coiled-coil domain Spc7 PF08317.11 EDO05097.1 - 5.4 5.8 9.9 1.8 7.4 4.9 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein VESA1_N PF12785.7 EDO05099.1 - 5.3e-15 55.3 17.2 2.3e-10 40.1 0.1 4.6 4 1 1 5 5 5 3 Variant erythrocyte surface antigen-1 Med3 PF11593.8 EDO05099.1 - 0.054 12.7 10.3 0.008 15.4 6.1 1.6 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal VESA1_N PF12785.7 EDO05100.1 - 6e-220 730.9 15.2 1.6e-219 729.6 15.2 1.7 1 0 0 1 1 1 1 Variant erythrocyte surface antigen-1 Exonuc_VII_L PF02601.15 EDO05100.1 - 0.048 13.2 1.5 0.086 12.4 1.5 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit PLU-1 PF08429.11 EDO05100.1 - 0.055 12.6 0.9 0.12 11.6 0.9 1.5 1 0 0 1 1 1 0 PLU-1-like protein DUF4398 PF14346.6 EDO05100.1 - 0.063 13.9 7.1 0.07 13.8 0.9 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4398) Spc7 PF08317.11 EDO05100.1 - 0.35 9.7 9.0 0.2 10.5 6.8 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF2959 PF11172.8 EDO05100.1 - 0.5 10.5 3.3 1.5 8.9 3.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2959) DUF4618 PF15397.6 EDO05100.1 - 1.2 8.5 4.8 3.1 7.2 4.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) DUF2564 PF10819.8 EDO05100.1 - 8.5 6.9 8.2 6.9 7.1 1.6 3.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2564) VESA1_N PF12785.7 EDO05101.1 - 1.4e-24 86.9 20.3 9.8e-11 41.3 0.1 3.1 2 1 1 3 3 3 3 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO05102.1 - 8.8e-211 700.7 22.5 8.8e-211 700.7 22.5 3.0 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 Apolipoprotein PF01442.18 EDO05102.1 - 0.0043 16.9 1.0 0.01 15.7 1.0 1.6 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain DUF5104 PF17117.5 EDO05102.1 - 0.025 15.0 0.3 0.11 13.0 0.3 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5104) DUF4795 PF16043.5 EDO05102.1 - 0.028 14.0 2.5 0.18 11.4 1.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) ABC_tran_CTD PF16326.5 EDO05102.1 - 0.085 13.1 1.8 0.18 12.1 0.7 2.1 2 0 0 2 2 2 0 ABC transporter C-terminal domain PEP-utilisers_N PF05524.13 EDO05102.1 - 0.11 12.6 0.8 2.7 8.2 0.2 2.4 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal Baculo_PEP_C PF04513.12 EDO05102.1 - 0.19 11.7 2.4 2.6 8.1 0.1 3.1 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus CdvA PF18822.1 EDO05102.1 - 0.35 10.7 5.1 3.1 7.6 2.4 2.9 2 0 0 2 2 2 0 CdvA-like coiled-coil domain Prefoldin_2 PF01920.20 EDO05102.1 - 1.7 8.6 13.3 0.04 13.9 3.7 3.0 3 1 0 3 3 3 0 Prefoldin subunit SecY PF00344.20 EDO05103.1 - 1e-68 231.9 11.6 1.3e-68 231.5 11.6 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 EDO05103.1 - 2.3e-17 62.5 1.3 6.4e-17 61.1 0.0 2.4 2 0 0 2 2 2 1 Plug domain of Sec61p vATP-synt_E PF01991.18 EDO05104.1 - 3.5e-29 101.6 8.5 4e-29 101.5 8.5 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit Aa_trans PF01490.18 EDO05104.1 - 0.16 10.6 0.0 0.23 10.1 0.0 1.1 1 0 0 1 1 1 0 Transmembrane amino acid transporter protein AP2 PF00847.20 EDO05105.1 - 5.5e-06 26.5 1.8 5.5e-06 26.5 1.8 2.0 2 0 0 2 2 2 1 AP2 domain polyprenyl_synt PF00348.17 EDO05106.1 - 3.4e-60 203.3 0.1 8.1e-38 129.9 0.0 2.1 1 1 1 2 2 2 2 Polyprenyl synthetase MBF1 PF08523.10 EDO05107.1 - 1.5e-19 70.2 0.9 1.9e-19 69.8 0.2 1.5 2 0 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 EDO05107.1 - 6.5e-12 45.3 0.2 1e-11 44.7 0.2 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 EDO05107.1 - 2.8e-08 34.0 0.0 4.3e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 EDO05107.1 - 0.00018 21.4 0.0 0.00036 20.5 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_25 PF13413.6 EDO05107.1 - 0.0059 16.4 0.1 0.0094 15.8 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 EDO05107.1 - 0.0063 16.9 0.0 0.0094 16.4 0.0 1.3 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_37 PF13744.6 EDO05107.1 - 0.025 14.5 0.1 0.037 14.0 0.1 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain RPA_C PF08784.11 EDO05108.1 - 0.0066 17.1 0.0 0.011 16.4 0.0 1.5 1 1 0 1 1 1 1 Replication protein A C terminal TFIIF_beta PF02270.15 EDO05108.1 - 0.0075 16.4 0.0 0.016 15.4 0.0 1.6 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain CdiA_C_tRNase PF18664.1 EDO05108.1 - 0.04 14.1 0.6 0.11 12.7 0.1 2.0 3 0 0 3 3 3 0 CdiA C-terminal tRNase domain ThiF PF00899.21 EDO05109.1 - 5.8e-16 58.6 0.0 8.9e-16 58.0 0.0 1.3 1 1 0 1 1 1 1 ThiF family Ish1 PF10281.9 EDO05110.1 - 0.013 15.7 0.9 0.05 13.9 0.4 2.2 2 0 0 2 2 2 0 Putative stress-responsive nuclear envelope protein Pkinase PF00069.25 EDO05111.1 - 1.9e-55 188.1 0.0 1.7e-54 185.0 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO05111.1 - 3.2e-26 92.2 0.0 2e-18 66.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase FTA2 PF13095.6 EDO05111.1 - 0.0038 16.9 0.2 0.87 9.2 0.0 2.5 3 0 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EDO05111.1 - 0.0087 15.7 0.4 0.12 11.9 0.0 2.2 1 1 0 2 2 2 1 RIO1 family APH PF01636.23 EDO05111.1 - 0.014 15.3 1.3 0.54 10.1 0.3 2.4 2 1 1 3 3 3 0 Phosphotransferase enzyme family CBFD_NFYB_HMF PF00808.23 EDO05112.1 - 3.8e-23 81.5 0.2 6.1e-23 80.9 0.2 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDO05112.1 - 0.00068 20.0 0.0 0.0011 19.3 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Peptidase_C13 PF01650.18 EDO05114.1 - 7e-09 35.6 1.1 2.3e-06 27.4 0.1 2.2 2 0 0 2 2 2 2 Peptidase C13 family ParA PF10609.9 EDO05116.1 - 1e-61 208.5 0.4 1.5e-39 135.9 0.0 2.0 2 0 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EDO05116.1 - 1.5e-10 41.2 0.0 1.7e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EDO05116.1 - 1.7e-08 34.6 0.6 2.3e-07 30.9 0.3 2.4 2 1 0 2 2 2 1 AAA domain ArsA_ATPase PF02374.15 EDO05116.1 - 1.1e-06 28.1 1.1 0.0022 17.2 0.2 2.7 2 1 1 3 3 3 2 Anion-transporting ATPase MipZ PF09140.11 EDO05116.1 - 1.3e-05 24.6 0.1 2.6e-05 23.6 0.1 1.5 1 0 0 1 1 1 1 ATPase MipZ CBP_BcsQ PF06564.12 EDO05116.1 - 0.0004 19.9 0.1 0.0074 15.8 0.1 2.1 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ SRP54 PF00448.22 EDO05116.1 - 0.077 12.6 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain CLP1_P PF16575.5 EDO05116.1 - 0.083 12.7 0.2 0.18 11.6 0.0 1.6 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_26 PF13500.6 EDO05116.1 - 0.085 12.7 0.2 0.91 9.3 0.1 2.1 2 0 0 2 2 2 0 AAA domain VirC1 PF07015.11 EDO05116.1 - 0.1 11.9 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 VirC1 protein MeaB PF03308.16 EDO05116.1 - 0.13 11.2 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Ribosomal_S7 PF00177.21 EDO05117.1 - 4.8e-38 130.1 1.0 6.2e-38 129.8 1.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Arf PF00025.21 EDO05118.1 - 2.3e-13 50.0 0.0 2.6e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EDO05118.1 - 0.00024 20.6 0.0 0.00029 20.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EDO05118.1 - 0.0023 18.2 0.0 0.0047 17.1 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EDO05118.1 - 0.013 15.6 0.0 0.024 14.7 0.0 1.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_33 PF13671.6 EDO05118.1 - 0.015 15.5 0.0 0.021 15.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain Gtr1_RagA PF04670.12 EDO05118.1 - 0.028 13.8 0.0 0.033 13.6 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_14 PF13173.6 EDO05118.1 - 0.12 12.4 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF1192 PF06698.11 EDO05119.1 - 0.018 15.1 0.1 0.046 13.8 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) KxDL PF10241.9 EDO05119.1 - 0.082 13.2 4.5 5.2 7.4 0.4 3.5 2 1 0 2 2 2 0 Uncharacterized conserved protein DUF948 PF06103.11 EDO05119.1 - 0.5 10.7 4.3 28 5.1 0.9 3.8 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) BST2 PF16716.5 EDO05119.1 - 0.91 10.2 4.9 0.76 10.4 0.8 2.8 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 FlxA PF14282.6 EDO05119.1 - 2.3 8.3 6.5 0.21 11.6 0.6 2.3 2 0 0 2 2 2 0 FlxA-like protein TPR_MLP1_2 PF07926.12 EDO05119.1 - 2.9 8.0 10.1 3.9 7.5 4.4 2.9 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein ABC_tran_CTD PF16326.5 EDO05119.1 - 2.9 8.2 9.1 1 9.7 2.5 3.2 2 1 0 2 2 2 0 ABC transporter C-terminal domain DUF745 PF05335.13 EDO05119.1 - 3.6 7.3 7.1 7.5 6.2 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF745) BLOC1_2 PF10046.9 EDO05119.1 - 4.1 7.8 8.2 3.7 7.9 1.2 3.1 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Alpha_adaptinC2 PF02883.20 EDO05120.1 - 0.032 14.6 0.1 0.75 10.1 0.0 2.7 2 0 0 2 2 2 0 Adaptin C-terminal domain VCX_VCY PF15231.6 EDO05120.1 - 0.089 13.5 0.0 0.16 12.6 0.0 1.3 1 0 0 1 1 1 0 Variable charge X/Y family Importin_rep PF18773.1 EDO05121.1 - 0.33 10.7 4.1 0.6 9.9 4.1 1.4 1 0 0 1 1 1 0 Importin 13 repeat Pro_isomerase PF00160.21 EDO05122.1 - 2.7e-47 161.0 0.8 4.4e-47 160.3 0.8 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD FKBP_C PF00254.28 EDO05122.1 - 8.4e-30 103.0 0.0 1.7e-29 102.0 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.28 EDO05122.1 - 1.7e-07 30.8 0.0 0.0099 15.7 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDO05122.1 - 3.4e-06 26.8 0.6 0.34 11.1 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EDO05122.1 - 8.3e-05 22.7 0.0 0.00016 21.8 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDO05122.1 - 0.00012 22.0 0.1 0.97 9.8 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EDO05122.1 - 0.00044 20.2 0.3 0.0012 18.9 0.1 1.8 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 EDO05122.1 - 0.019 15.6 0.4 36 5.3 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 EDO05122.1 - 0.026 14.8 3.9 3.2 8.1 0.1 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EDO05122.1 - 0.027 15.0 0.9 4.3 7.9 0.0 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 EDO05122.1 - 0.033 14.3 0.6 1.7 8.8 0.0 2.6 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_7 PF13176.6 EDO05122.1 - 0.13 12.4 1.7 5.6 7.2 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDO05122.1 - 0.14 12.9 2.0 17 6.2 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat PIG-S PF10510.9 EDO05123.1 - 0.11 11.3 0.3 9.6 4.9 0.0 2.1 2 0 0 2 2 2 0 Phosphatidylinositol-glycan biosynthesis class S protein Actin PF00022.19 EDO05124.1 - 1.8e-142 474.7 0.0 1.4e-141 471.9 0.0 1.8 1 1 0 1 1 1 1 Actin FAD_binding_3 PF01494.19 EDO05125.1 - 2.3e-40 138.9 0.0 4.3e-24 85.4 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain SE PF08491.10 EDO05125.1 - 0.042 12.9 0.2 0.48 9.4 0.2 2.1 1 1 0 1 1 1 0 Squalene epoxidase RNase_P_p30 PF01876.16 EDO05128.1 - 6.1e-17 61.8 0.0 7.9e-17 61.4 0.0 1.2 1 0 0 1 1 1 1 RNase P subunit p30 Pkinase PF00069.25 EDO05129.1 - 1.7e-40 139.1 0.0 2.1e-40 138.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO05129.1 - 5.1e-20 71.8 0.0 6.8e-20 71.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDO05129.1 - 0.0001 22.3 0.0 0.016 15.1 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EDO05129.1 - 0.00011 21.6 0.0 0.00018 20.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EDO05129.1 - 0.00053 19.4 0.0 0.00072 18.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Choline_kinase PF01633.20 EDO05129.1 - 0.052 13.1 0.0 0.075 12.6 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase XPG_I PF00867.18 EDO05131.1 - 1.7e-26 92.4 0.1 3.5e-26 91.4 0.1 1.6 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 EDO05131.1 - 1.7e-24 86.2 0.0 4.2e-24 85.0 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 EDO05131.1 - 8.8e-05 23.0 0.0 0.00043 20.8 0.0 2.3 1 1 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold 5_3_exonuc_N PF02739.16 EDO05131.1 - 0.0079 16.1 0.0 0.022 14.7 0.0 1.7 1 1 0 1 1 1 1 5'-3' exonuclease, N-terminal resolvase-like domain Fe_dep_repr_C PF02742.15 EDO05131.1 - 0.017 15.2 0.1 1.7 8.8 0.0 4.0 4 2 2 6 6 6 0 Iron dependent repressor, metal binding and dimerisation domain HHH_2 PF12826.7 EDO05131.1 - 0.039 14.0 0.0 0.25 11.5 0.0 2.4 2 1 0 2 2 2 0 Helix-hairpin-helix motif HHH_5 PF14520.6 EDO05131.1 - 0.1 13.2 0.1 1.2 9.9 0.0 2.5 2 0 0 2 2 2 0 Helix-hairpin-helix domain PRCC PF10253.9 EDO05131.1 - 4.8 7.9 4.7 5.5 7.7 2.0 2.2 2 0 0 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting zf-RanBP PF00641.18 EDO05132.1 - 8.1e-09 34.6 17.3 7.9e-05 21.9 7.8 2.5 2 1 0 2 2 2 2 Zn-finger in Ran binding protein and others DZR PF12773.7 EDO05132.1 - 0.066 13.2 12.3 1.1 9.3 10.6 2.3 1 1 1 2 2 2 0 Double zinc ribbon RecR PF02132.15 EDO05132.1 - 0.093 12.3 1.7 0.093 12.3 1.7 2.8 3 1 0 3 3 3 0 RecR protein GBP PF02263.19 EDO05133.1 - 7.2e-06 25.5 0.1 5.2e-05 22.6 0.0 2.2 2 0 0 2 2 2 1 Guanylate-binding protein, N-terminal domain AAA_22 PF13401.6 EDO05133.1 - 0.06 13.6 0.0 0.31 11.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF4795 PF16043.5 EDO05133.1 - 2.1 7.9 9.2 0.19 11.3 3.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) LUC7 PF03194.15 EDO05133.1 - 3 7.5 10.5 0.039 13.6 0.7 2.5 3 0 0 3 3 3 0 LUC7 N_terminus PRESAN PF09687.10 EDO05133.1 - 3.8 8.1 12.2 0.2 12.2 3.4 2.9 3 0 0 3 3 3 0 Plasmodium RESA N-terminal AAA PF00004.29 EDO05134.1 - 1.6e-36 125.6 0.0 2.7e-36 124.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EDO05134.1 - 2.4e-05 24.1 0.0 4.2e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EDO05134.1 - 5.2e-05 23.3 0.0 0.00032 20.7 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EDO05134.1 - 7e-05 23.0 0.0 0.00015 21.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_lid_3 PF17862.1 EDO05134.1 - 0.00023 20.9 0.0 0.00067 19.4 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EDO05134.1 - 0.00069 20.0 0.0 0.0022 18.4 0.0 1.8 2 1 0 2 2 1 1 AAA ATPase domain AAA_22 PF13401.6 EDO05134.1 - 0.0012 19.1 0.1 0.006 16.9 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EDO05134.1 - 0.0066 16.5 0.0 0.014 15.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 EDO05134.1 - 0.0071 16.3 0.0 0.013 15.5 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 EDO05134.1 - 0.0086 15.7 0.1 0.021 14.4 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDO05134.1 - 0.0092 16.1 0.0 0.017 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDO05134.1 - 0.0096 16.5 0.0 0.024 15.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain Vps4_C PF09336.10 EDO05134.1 - 0.015 15.3 0.0 0.037 14.0 0.0 1.7 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain IstB_IS21 PF01695.17 EDO05134.1 - 0.022 14.5 0.0 0.043 13.6 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 EDO05134.1 - 0.025 14.0 0.0 0.045 13.1 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI MCM PF00493.23 EDO05134.1 - 0.025 13.7 0.2 0.074 12.1 0.0 1.8 2 0 0 2 2 2 0 MCM P-loop domain NACHT PF05729.12 EDO05134.1 - 0.028 14.3 0.1 0.052 13.5 0.1 1.4 1 0 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 EDO05134.1 - 0.031 14.0 0.0 0.061 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EDO05134.1 - 0.033 14.4 0.0 0.056 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EDO05134.1 - 0.05 14.1 0.0 0.15 12.6 0.0 1.8 2 0 0 2 2 1 0 ABC transporter AAA_8 PF12780.7 EDO05134.1 - 0.059 12.7 0.0 0.096 12.0 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region D4 TIP49 PF06068.13 EDO05134.1 - 0.064 12.5 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain RNA_helicase PF00910.22 EDO05134.1 - 0.064 13.6 0.0 0.25 11.7 0.0 2.0 2 0 0 2 2 2 0 RNA helicase MMR_HSR1 PF01926.23 EDO05134.1 - 0.091 12.9 0.0 0.27 11.3 0.0 1.8 2 0 0 2 2 1 0 50S ribosome-binding GTPase AAA_7 PF12775.7 EDO05134.1 - 0.11 12.0 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 EDO05134.1 - 0.14 11.9 0.6 0.22 11.2 0.1 1.5 2 0 0 2 2 1 0 AAA domain Form_Nir_trans PF01226.17 EDO05135.1 - 5.6e-55 186.2 20.0 6.4e-55 186.1 20.0 1.0 1 0 0 1 1 1 1 Formate/nitrite transporter zf-RING_2 PF13639.6 EDO05136.1 - 2.9e-07 30.7 9.6 2.9e-07 30.7 9.6 2.5 2 0 0 2 2 2 1 Ring finger domain FANCL_C PF11793.8 EDO05136.1 - 1.2e-06 28.6 5.2 6.2e-06 26.3 5.2 2.3 1 0 0 1 1 1 1 FANCL C-terminal domain zf-rbx1 PF12678.7 EDO05136.1 - 4e-05 23.8 11.9 0.00035 20.8 10.8 3.0 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EDO05136.1 - 4.1e-05 23.5 2.1 0.00021 21.3 2.1 2.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 EDO05136.1 - 0.00011 21.9 10.3 0.013 15.3 10.9 3.0 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EDO05136.1 - 0.0012 18.5 9.4 0.004 16.8 6.2 2.6 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 EDO05136.1 - 0.0049 16.9 8.3 0.015 15.3 8.3 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EDO05136.1 - 0.0057 16.5 11.9 0.015 15.2 10.3 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 EDO05136.1 - 0.73 9.7 4.9 2.4 8.0 4.9 2.0 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 EDO05136.1 - 1.5 8.8 6.0 3.7 7.5 3.1 2.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING-like PF08746.11 EDO05136.1 - 2.2 8.6 12.8 0.35 11.2 8.1 2.3 2 0 0 2 2 1 0 RING-like domain Zf_RING PF16744.5 EDO05136.1 - 2.6 8.2 5.4 2.2 8.5 2.6 2.5 2 0 0 2 2 1 0 KIAA1045 RING finger C1_1 PF00130.22 EDO05136.1 - 3 7.8 9.1 1.3 9.0 5.0 2.5 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_11 PF17123.5 EDO05136.1 - 6.1 6.7 7.7 23 4.8 7.7 2.1 1 0 0 1 1 1 0 RING-like zinc finger Bax1-I PF01027.20 EDO05137.1 - 2.8e-27 95.9 27.6 3.3e-27 95.7 27.6 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF2583 PF10762.9 EDO05137.1 - 3.7 8.0 6.8 2.3 8.7 4.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2583) FTA4 PF13093.6 EDO05138.1 - 0.019 14.9 0.4 0.028 14.3 0.4 1.2 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 MRP-L28 PF09812.9 EDO05138.1 - 0.026 14.7 0.1 0.026 14.7 0.1 1.8 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L28 TruD PF01142.18 EDO05139.1 - 2.7e-55 187.9 0.3 3.1e-36 125.1 0.1 4.2 4 1 0 4 4 4 3 tRNA pseudouridine synthase D (TruD) Synaptobrevin PF00957.21 EDO05140.1 - 7.6e-08 32.1 0.5 1.3e-07 31.3 0.5 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EDO05140.1 - 1.4e-07 31.4 0.0 2.3e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Mce4_CUP1 PF11887.8 EDO05140.1 - 0.0031 17.0 0.3 0.0043 16.5 0.3 1.1 1 0 0 1 1 1 1 Cholesterol uptake porter CUP1 of Mce4, putative VitK2_biosynth PF02621.14 EDO05140.1 - 0.11 12.0 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 Menaquinone biosynthesis IMS PF00817.20 EDO05141.1 - 4.3e-37 127.4 1.6 8.5e-37 126.5 0.3 2.2 2 0 0 2 2 2 1 impB/mucB/samB family BRCT_2 PF16589.5 EDO05141.1 - 4e-07 30.4 0.2 2.1e-06 28.0 0.0 2.4 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain IMS_HHH PF11798.8 EDO05141.1 - 0.00084 19.5 0.0 0.0026 18.0 0.0 1.9 1 0 0 1 1 1 1 IMS family HHH motif DUF1805 PF08827.11 EDO05141.1 - 0.085 13.2 0.0 0.35 11.2 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1805) AAA PF00004.29 EDO05142.1 - 2.3e-43 147.8 0.0 1.3e-42 145.4 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO05142.1 - 7e-11 41.8 0.8 1.5e-10 40.7 0.1 1.9 2 0 0 2 2 1 1 AAA+ lid domain AAA_5 PF07728.14 EDO05142.1 - 1.9e-09 37.6 0.1 1.9e-08 34.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EDO05142.1 - 1e-06 29.0 0.0 2e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EDO05142.1 - 4.3e-06 27.2 0.3 6.5e-05 23.4 0.1 2.4 1 1 0 2 2 2 1 AAA ATPase domain Prot_ATP_ID_OB PF16450.5 EDO05142.1 - 5.8e-05 23.0 0.2 0.00017 21.5 0.2 1.8 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain RuvB_N PF05496.12 EDO05142.1 - 6.8e-05 22.7 0.0 0.00015 21.5 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EDO05142.1 - 0.00011 22.4 0.3 0.0072 16.6 0.3 2.5 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDO05142.1 - 0.0008 19.6 0.6 0.0024 18.0 0.0 2.2 3 0 0 3 3 3 1 AAA domain TIP49 PF06068.13 EDO05142.1 - 0.0012 18.2 0.0 0.0026 17.0 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_18 PF13238.6 EDO05142.1 - 0.0027 18.2 0.1 0.018 15.6 0.0 2.4 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 EDO05142.1 - 0.0034 17.1 0.0 0.006 16.3 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.11 EDO05142.1 - 0.0064 16.4 0.0 0.016 15.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EDO05142.1 - 0.0074 16.5 0.3 0.023 14.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EDO05142.1 - 0.01 15.2 0.1 0.026 13.9 0.1 1.6 2 0 0 2 2 1 0 Magnesium chelatase, subunit ChlI TsaE PF02367.17 EDO05142.1 - 0.017 15.2 0.0 0.032 14.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 EDO05142.1 - 0.019 14.3 0.0 0.06 12.7 0.0 1.8 2 0 0 2 2 2 0 KaiC AAA_7 PF12775.7 EDO05142.1 - 0.02 14.4 0.0 0.035 13.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EDO05142.1 - 0.024 15.0 0.0 0.055 13.9 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 EDO05142.1 - 0.024 14.4 0.0 0.082 12.6 0.0 1.9 1 1 1 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EDO05142.1 - 0.027 14.2 0.0 0.12 12.1 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain PhoH PF02562.16 EDO05142.1 - 0.028 13.9 0.0 0.15 11.5 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein Parvo_NS1 PF01057.17 EDO05142.1 - 0.043 12.9 0.0 0.08 12.0 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_11 PF13086.6 EDO05142.1 - 0.052 13.3 0.1 0.31 10.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 EDO05142.1 - 0.055 12.6 0.0 0.11 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_25 PF13481.6 EDO05142.1 - 0.059 12.9 0.2 0.17 11.4 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_14 PF13173.6 EDO05142.1 - 0.071 13.1 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EDO05142.1 - 0.077 13.5 0.1 0.31 11.5 0.1 2.4 2 1 0 2 2 2 0 ABC transporter Zeta_toxin PF06414.12 EDO05142.1 - 0.08 12.2 0.1 0.24 10.6 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin AAA_17 PF13207.6 EDO05142.1 - 0.11 12.9 0.2 0.37 11.2 0.0 2.0 3 0 0 3 3 1 0 AAA domain NACHT PF05729.12 EDO05142.1 - 0.13 12.2 0.0 0.74 9.7 0.0 2.0 2 0 0 2 2 2 0 NACHT domain PP2C PF00481.21 EDO05145.1 - 7.9e-43 146.9 0.1 1.6e-42 146.0 0.1 1.5 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EDO05145.1 - 0.026 14.5 0.0 0.053 13.4 0.0 1.5 1 0 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) Tho2 PF11262.8 EDO05146.1 - 1.1e-71 241.6 0.1 1.6e-71 241.0 0.1 1.3 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 THOC2_N PF16134.5 EDO05146.1 - 1.5e-22 80.1 0.0 1.4e-10 40.4 0.4 3.2 3 0 0 3 3 3 3 THO complex subunit 2 N-terminus Thoc2 PF11732.8 EDO05146.1 - 2.4e-07 30.7 0.0 6.1e-07 29.4 0.0 1.7 1 0 0 1 1 1 1 Transcription- and export-related complex subunit Spectrin PF00435.21 EDO05146.1 - 0.051 14.1 1.0 0.14 12.6 1.0 1.7 1 0 0 1 1 1 0 Spectrin repeat GAS PF13851.6 EDO05146.1 - 3 7.2 5.6 6.8 6.0 1.4 2.5 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding Fcf2 PF08698.11 EDO05147.1 - 1.6e-14 54.1 0.3 3.7e-14 52.9 0.3 1.6 1 0 0 1 1 1 1 Fcf2 pre-rRNA processing Peptidase_C1 PF00112.23 EDO05148.1 - 2.4e-41 142.2 1.4 5.5e-41 141.0 1.4 1.6 1 0 0 1 1 1 1 Papain family cysteine protease CathepsinC_exc PF08773.11 EDO05148.1 - 2.1e-11 44.2 0.2 2.4e-10 40.7 0.2 2.4 1 1 0 1 1 1 1 Cathepsin C exclusion domain Peptidase_C1_2 PF03051.15 EDO05148.1 - 0.13 11.0 2.3 0.23 10.2 1.2 1.9 3 0 0 3 3 3 0 Peptidase C1-like family zf_CCCH_4 PF18345.1 EDO05150.1 - 2.6e-06 27.3 1.3 6.4e-06 26.1 1.3 1.7 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 EDO05150.1 - 7.4e-06 25.8 0.4 2.1e-05 24.3 0.4 1.9 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EDO05150.1 - 0.00027 20.6 1.0 0.0006 19.5 1.0 1.6 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 EDO05150.1 - 0.0033 17.8 0.8 0.012 16.1 0.8 2.0 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger Torus PF16131.5 EDO05150.1 - 0.0081 16.8 0.6 0.02 15.6 0.3 1.8 1 1 0 1 1 1 1 Torus domain Bud13 PF09736.9 EDO05151.1 - 5.4e-41 140.4 2.0 7.8e-41 139.9 2.0 1.2 1 0 0 1 1 1 1 Pre-mRNA-splicing factor of RES complex DUF4604 PF15377.6 EDO05151.1 - 8.7 6.7 8.5 30 5.0 8.6 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4604) B9-C2 PF07162.11 EDO05152.1 - 0.12 12.6 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Ciliary basal body-associated, B9 protein SRPRB PF09439.10 EDO05153.1 - 6e-11 42.1 0.2 6.3e-11 42.0 0.2 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 EDO05153.1 - 6e-08 32.3 0.0 8.1e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EDO05153.1 - 0.00012 22.1 0.0 0.00027 21.0 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 EDO05153.1 - 0.0014 18.3 0.0 0.0017 18.0 0.0 1.2 1 0 0 1 1 1 1 Ras family GTP_EFTU PF00009.27 EDO05153.1 - 0.0027 17.3 0.0 0.0032 17.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain NOG1 PF06858.14 EDO05153.1 - 0.039 13.7 0.1 0.066 13.0 0.1 1.4 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) Arg_decarbox_C PF17944.1 EDO05153.1 - 0.097 13.2 0.0 0.18 12.4 0.0 1.5 1 0 0 1 1 1 0 Arginine decarboxylase C-terminal helical extension ABC_tran PF00005.27 EDO05154.1 - 7.5e-33 114.0 0.1 1.2e-32 113.2 0.1 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EDO05154.1 - 1.4e-25 90.5 15.4 1.8e-25 90.1 15.4 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 EDO05154.1 - 6e-09 35.7 0.2 2.4e-07 30.4 0.2 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EDO05154.1 - 7.6e-07 29.2 0.1 0.0055 16.6 0.1 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EDO05154.1 - 0.00017 22.0 0.0 0.00043 20.7 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain DLIC PF05783.11 EDO05154.1 - 0.00055 18.9 0.0 0.0013 17.6 0.0 1.6 2 0 0 2 2 2 1 Dynein light intermediate chain (DLIC) RsgA_GTPase PF03193.16 EDO05154.1 - 0.0013 18.7 0.5 0.021 14.7 0.2 2.5 1 1 1 2 2 2 1 RsgA GTPase AAA PF00004.29 EDO05154.1 - 0.015 15.7 0.1 0.23 11.9 0.1 2.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDO05154.1 - 0.02 15.2 0.5 0.11 12.8 0.5 2.1 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EDO05154.1 - 0.033 14.2 0.1 0.17 11.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 EDO05154.1 - 0.034 14.1 1.6 2.8 7.9 0.0 2.7 3 0 0 3 3 3 0 NACHT domain DEAD PF00270.29 EDO05154.1 - 0.036 13.8 0.1 0.12 12.1 0.1 1.9 1 1 0 1 1 1 0 DEAD/DEAH box helicase Rad17 PF03215.15 EDO05154.1 - 0.051 13.5 0.4 11 5.8 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_29 PF13555.6 EDO05154.1 - 0.064 13.0 0.2 0.21 11.3 0.2 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain CobA_CobO_BtuR PF02572.15 EDO05154.1 - 0.067 13.5 0.1 0.15 12.3 0.1 1.5 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP ATP-synt_ab PF00006.25 EDO05154.1 - 0.09 12.4 0.2 0.53 9.9 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_15 PF13175.6 EDO05154.1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain FtsK_gamma PF09397.10 EDO05155.1 - 0.029 14.2 0.1 0.078 12.8 0.1 1.7 1 0 0 1 1 1 0 Ftsk gamma domain FAST_1 PF06743.15 EDO05157.1 - 0.033 14.1 0.0 0.43 10.6 0.0 2.5 1 1 2 3 3 3 0 FAST kinase-like protein, subdomain 1 DUF913 PF06025.12 EDO05157.1 - 0.071 12.1 0.1 0.072 12.1 0.1 1.3 1 1 0 1 1 1 0 Domain of Unknown Function (DUF913) ATP11 PF06644.11 EDO05158.1 - 3.6e-11 43.4 0.0 4e-11 43.2 0.0 1.1 1 0 0 1 1 1 1 ATP11 protein DHC_N2 PF08393.13 EDO05161.1 - 0.049 12.7 6.0 0.088 11.9 6.0 1.3 1 0 0 1 1 1 0 Dynein heavy chain, N-terminal region 2 Pyr_redox_2 PF07992.14 EDO05162.1 - 3.1e-08 33.2 0.0 1.1e-06 28.1 0.0 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDO05162.1 - 5.7e-05 23.3 0.0 0.00014 22.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EDO05162.1 - 0.012 16.1 0.0 0.56 10.8 0.0 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDO05162.1 - 0.017 15.1 0.1 0.065 13.2 0.0 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding Thi4 PF01946.17 EDO05162.1 - 0.044 13.0 0.0 0.19 10.9 0.0 1.9 2 0 0 2 2 2 0 Thi4 family FF PF01846.19 EDO05162.1 - 0.05 13.8 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 FF domain SPACA7 PF15307.6 EDO05163.1 - 0.046 14.0 0.5 0.14 12.5 0.5 1.8 1 0 0 1 1 1 0 Sperm acrosome-associated protein 7 Ribosomal_S14 PF00253.21 EDO05164.1 - 4.1e-18 64.9 0.3 8.7e-18 63.8 0.3 1.6 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e PP2C PF00481.21 EDO05165.1 - 8.2e-59 199.3 0.0 1.4e-50 172.4 0.0 2.4 2 0 0 2 2 2 2 Protein phosphatase 2C PIG-F PF06699.11 EDO05166.1 - 0.49 10.5 14.8 2.5 8.2 14.8 2.3 1 1 0 1 1 1 0 GPI biosynthesis protein family Pig-F Wzz PF02706.15 EDO05166.1 - 2.6 8.4 4.9 1.3 9.4 0.2 2.4 2 0 0 2 2 2 0 Chain length determinant protein DivIC PF04977.15 EDO05167.1 - 0.0012 18.6 11.9 0.0089 15.8 5.6 2.8 1 1 1 2 2 2 2 Septum formation initiator Seryl_tRNA_N PF02403.22 EDO05167.1 - 0.0033 17.6 4.7 0.0033 17.6 4.7 2.2 1 1 1 2 2 2 1 Seryl-tRNA synthetase N-terminal domain HALZ PF02183.18 EDO05167.1 - 0.031 14.5 5.8 0.12 12.6 5.8 2.0 1 0 0 1 1 1 0 Homeobox associated leucine zipper Syntaxin-6_N PF09177.11 EDO05167.1 - 0.033 14.7 3.3 0.4 11.3 3.5 2.7 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Bcl-2_3 PF15286.6 EDO05167.1 - 0.16 12.6 0.0 0.41 11.3 0.0 1.7 1 0 0 1 1 1 0 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like V_ATPase_I PF01496.19 EDO05167.1 - 0.27 9.1 4.0 0.41 8.5 4.0 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 EDO05167.1 - 0.38 10.0 7.4 0.62 9.4 7.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Snapin_Pallidin PF14712.6 EDO05167.1 - 0.46 10.9 9.4 0.26 11.7 5.9 2.4 1 1 1 2 2 2 0 Snapin/Pallidin Prominin PF05478.11 EDO05167.1 - 0.61 8.0 5.0 0.9 7.4 5.0 1.3 1 0 0 1 1 1 0 Prominin APG6_N PF17675.1 EDO05167.1 - 1.2 9.7 13.8 4.4 7.8 13.8 2.0 1 0 0 1 1 1 0 Apg6 coiled-coil region JIP_LZII PF16471.5 EDO05167.1 - 1.4 9.1 7.8 3.1 8.0 5.7 2.7 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II FapA PF03961.13 EDO05167.1 - 1.5 7.4 4.7 2.7 6.5 4.7 1.5 1 0 0 1 1 1 0 Flagellar Assembly Protein A APC_N_CC PF16689.5 EDO05167.1 - 3.6 7.7 7.5 0.56 10.3 2.9 2.1 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain ZapB PF06005.12 EDO05167.1 - 5.7 7.5 18.3 0.59 10.6 10.1 3.2 2 1 1 3 3 3 0 Cell division protein ZapB DUF4446 PF14584.6 EDO05167.1 - 8.5 6.4 8.5 0.41 10.6 2.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF4446) Metallophos PF00149.28 EDO05168.1 - 3e-35 122.6 0.1 5.6e-35 121.7 0.1 1.4 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 EDO05168.1 - 0.021 14.5 0.0 0.032 13.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain DUF5378 PF17349.2 EDO05168.1 - 0.048 13.0 0.0 0.069 12.5 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5378) Metallophos_2 PF12850.7 EDO05168.1 - 0.049 13.8 0.0 0.085 13.0 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Urm1 PF09138.11 EDO05169.1 - 2.4e-23 82.3 0.0 2.9e-23 82.0 0.0 1.1 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) US6 PF17616.2 EDO05170.1 - 0.46 10.4 3.3 1.7 8.6 0.1 2.1 2 0 0 2 2 2 0 Viral unique short region 6 Guanylate_cyc PF00211.20 EDO05171.1 - 6.9e-78 260.5 1.1 1e-38 132.8 0.4 2.3 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain PhoLip_ATPase_C PF16212.5 EDO05171.1 - 3.5e-29 102.3 20.1 3.5e-29 102.3 20.1 4.4 4 0 0 4 4 4 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 EDO05171.1 - 1.3e-09 38.6 0.1 0.00056 20.3 0.0 3.4 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EDO05171.1 - 7.3e-09 35.4 0.1 7.3e-09 35.4 0.1 3.8 4 1 0 4 4 4 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EDO05171.1 - 6.7e-07 29.3 0.0 1.9e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDO05171.1 - 0.024 14.7 0.0 0.075 13.1 0.0 1.8 1 0 0 1 1 1 0 Cation transport ATPase (P-type) AcrZ PF10766.9 EDO05171.1 - 0.34 10.5 1.7 1.5 8.4 1.7 2.3 1 0 0 1 1 1 0 Multidrug efflux pump-associated protein AcrZ ELMO_CED12 PF04727.13 EDO05172.1 - 5.6e-29 101.5 0.2 8.2e-29 100.9 0.2 1.3 1 0 0 1 1 1 1 ELMO/CED-12 family zf_C2H2_6 PF18450.1 EDO05173.1 - 0.0012 18.5 0.2 0.0026 17.4 0.2 1.5 1 0 0 1 1 1 1 Zinc Finger domain zf-C2H2_11 PF16622.5 EDO05173.1 - 0.018 14.8 0.4 0.018 14.8 0.4 1.9 2 0 0 2 2 2 0 zinc-finger C2H2-type CEP63 PF17045.5 EDO05174.1 - 0.0024 17.8 6.9 0.004 17.1 6.9 1.3 1 0 0 1 1 1 1 Centrosomal protein of 63 kDa Transcrip_act PF04949.13 EDO05174.1 - 0.0042 17.0 3.7 0.0073 16.2 3.7 1.3 1 0 0 1 1 1 1 Transcriptional activator APG6_N PF17675.1 EDO05174.1 - 0.0084 16.6 8.8 0.02 15.4 8.8 1.6 1 0 0 1 1 1 1 Apg6 coiled-coil region DUF2205 PF10224.9 EDO05174.1 - 0.022 14.7 2.1 0.065 13.2 2.1 1.8 1 0 0 1 1 1 0 Short coiled-coil protein DUF3972 PF13118.6 EDO05174.1 - 0.038 14.4 2.6 0.038 14.4 2.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3972) ERM PF00769.19 EDO05174.1 - 0.041 13.7 8.0 0.064 13.1 8.0 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family AAA_13 PF13166.6 EDO05174.1 - 0.044 12.4 6.7 0.041 12.5 5.6 1.5 2 0 0 2 2 2 0 AAA domain DUF641 PF04859.12 EDO05174.1 - 0.048 14.0 3.8 0.11 12.9 3.8 1.6 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) DUF1319 PF07028.11 EDO05174.1 - 0.15 12.3 4.4 0.27 11.5 4.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1319) CHDCT2 PF08074.11 EDO05174.1 - 0.24 11.6 3.3 0.53 10.4 3.0 1.8 1 1 0 1 1 1 0 CHDCT2 (NUC038) domain FlaC_arch PF05377.11 EDO05174.1 - 0.31 11.5 2.8 0.93 9.9 2.8 1.9 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) OmpH PF03938.14 EDO05174.1 - 0.41 11.0 7.6 0.76 10.1 7.6 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Atg14 PF10186.9 EDO05174.1 - 0.42 9.7 8.1 0.7 8.9 8.1 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 V_ATPase_I PF01496.19 EDO05174.1 - 0.43 8.4 3.5 0.59 8.0 3.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ATG16 PF08614.11 EDO05174.1 - 0.52 10.5 12.4 0.89 9.8 12.4 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Cep57_CLD_2 PF14197.6 EDO05174.1 - 1.1 9.4 9.1 0.41 10.8 4.1 2.7 3 1 0 3 3 3 0 Centrosome localisation domain of PPC89 FAM76 PF16046.5 EDO05174.1 - 2.4 7.4 4.5 3.8 6.8 4.5 1.2 1 0 0 1 1 1 0 FAM76 protein TMPIT PF07851.13 EDO05174.1 - 2.6 7.2 6.0 3.8 6.7 6.0 1.2 1 0 0 1 1 1 0 TMPIT-like protein Sin_N PF04801.13 EDO05175.1 - 3.5e-30 105.6 1.6 1.4e-21 77.2 0.1 3.2 3 0 0 3 3 3 3 Sin-like protein conserved region Kelch_4 PF13418.6 EDO05176.1 - 1.7e-40 136.8 16.3 1.4e-09 37.8 0.1 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.25 EDO05176.1 - 1.6e-25 88.4 15.5 2.1e-05 24.0 0.0 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 EDO05176.1 - 2.3e-25 88.3 16.3 0.00021 21.5 0.0 6.1 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 EDO05176.1 - 3.9e-24 84.1 21.4 6.5e-06 26.2 0.1 6.6 5 1 1 6 6 6 4 Kelch motif Kelch_5 PF13854.6 EDO05176.1 - 5.3e-24 83.7 13.6 6.7e-06 26.0 0.1 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 EDO05176.1 - 7.7e-17 60.5 16.5 6.5e-05 22.7 0.7 6.2 6 1 0 6 6 6 5 Kelch motif EGF_2 PF07974.13 EDO05176.1 - 0.014 15.8 10.9 0.014 15.8 10.9 2.1 2 0 0 2 2 2 0 EGF-like domain EGF_alliinase PF04863.13 EDO05176.1 - 0.33 11.4 3.5 0.84 10.1 3.5 1.7 1 0 0 1 1 1 0 Alliinase EGF-like domain hEGF PF12661.7 EDO05176.1 - 1.1 10.0 8.8 6.7 7.5 5.1 3.0 2 0 0 2 2 2 0 Human growth factor-like EGF EGF PF00008.27 EDO05176.1 - 8.2 6.8 12.0 2.3 8.6 8.6 1.8 2 0 0 2 2 2 0 EGF-like domain Fib_alpha PF08702.10 EDO05177.1 - 0.51 10.5 3.2 0.32 11.2 0.4 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Syntaxin_2 PF14523.6 EDO05177.1 - 1.6 9.1 4.6 16 5.9 0.1 3.5 3 0 0 3 3 3 0 Syntaxin-like protein ApoLp-III PF07464.11 EDO05177.1 - 2.6 8.1 5.8 0.63 10.1 1.0 2.2 2 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) CPW_WPC PF09717.10 EDO05178.1 - 4.9e-17 62.6 8.3 9.6e-17 61.7 8.3 1.5 1 0 0 1 1 1 1 Plasmodium falciparum domain of unknown function (CPW_WPC) Phage_min_cap2 PF06152.11 EDO05178.1 - 0.034 13.0 0.6 0.044 12.7 0.6 1.1 1 0 0 1 1 1 0 Phage minor capsid protein 2 TTRAP PF14203.6 EDO05178.1 - 0.049 13.6 0.9 0.097 12.7 0.9 1.4 1 0 0 1 1 1 0 Putative tranposon-transfer assisting protein Swm2 PF17083.5 EDO05178.1 - 0.071 13.1 0.7 0.086 12.9 0.2 1.4 2 0 0 2 2 2 0 Nucleolar protein Swm2 Hexokinase_1 PF00349.21 EDO05180.1 - 7.6e-53 179.4 0.0 1e-52 178.9 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 EDO05180.1 - 2.1e-47 161.6 0.1 2.8e-47 161.2 0.1 1.2 1 0 0 1 1 1 1 Hexokinase DUF3883 PF13020.6 EDO05181.1 - 2.5e-21 75.5 0.2 4.8e-21 74.6 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3883) zf-CCHC_5 PF14787.6 EDO05181.1 - 0.54 10.0 1.7 1.4 8.7 1.7 1.6 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger AKAP7_NLS PF10469.9 EDO05182.1 - 0.0017 18.3 0.2 0.0037 17.2 0.1 1.7 2 0 0 2 2 2 1 AKAP7 2'5' RNA ligase-like domain LigT_PEase PF02834.16 EDO05182.1 - 0.0026 17.9 0.1 0.081 13.1 0.0 2.8 2 0 0 2 2 2 1 LigT like Phosphoesterase BMFP PF04380.13 EDO05182.1 - 0.77 10.3 2.5 1.8 9.1 0.3 2.5 2 1 0 2 2 2 0 Membrane fusogenic activity DUF1840 PF08895.11 EDO05182.1 - 1 9.8 3.9 61 4.0 0.0 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF1840) RNase_HII PF01351.18 EDO05183.1 - 3.4e-48 164.1 0.0 4.1e-48 163.9 0.0 1.0 1 0 0 1 1 1 1 Ribonuclease HII Exo5 PF09810.9 EDO05184.1 - 2e-57 195.4 13.4 2.6e-32 112.8 1.2 3.1 1 1 2 3 3 3 3 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.7 EDO05184.1 - 6.4e-07 29.5 0.2 1e-06 28.9 0.2 1.3 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily CBP PF12192.8 EDO05184.1 - 0.16 12.2 0.0 0.31 11.2 0.0 1.4 1 0 0 1 1 1 0 Fungal calcium binding protein Brix PF04427.18 EDO05185.1 - 9.9e-34 117.1 1.0 1.2e-33 116.8 0.2 1.5 2 0 0 2 2 2 1 Brix domain PAP_central PF04928.17 EDO05187.1 - 1.3e-97 325.7 0.0 1.7e-97 325.3 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 EDO05187.1 - 1.2e-17 64.1 0.5 2e-10 40.5 0.1 2.4 1 1 1 2 2 2 2 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 EDO05187.1 - 1.4e-07 31.7 0.0 3.5e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 EDO05187.1 - 0.0015 18.3 0.0 0.0028 17.4 0.0 1.4 1 0 0 1 1 1 1 Nrap protein PAP/OAS-like domain ORC2 PF04084.14 EDO05188.1 - 1.3e-36 126.2 0.0 1.5e-36 126.0 0.0 1.0 1 0 0 1 1 1 1 Origin recognition complex subunit 2 DnaJ_C PF01556.18 EDO05190.1 - 7.6e-33 113.7 0.0 1e-32 113.3 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EDO05190.1 - 5.5e-21 74.5 0.6 9.6e-21 73.7 0.6 1.4 1 0 0 1 1 1 1 DnaJ domain zf-RING_10 PF16685.5 EDO05190.1 - 0.021 15.0 0.0 0.055 13.6 0.0 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 SabA_adhesion PF18304.1 EDO05190.1 - 0.2 10.8 0.0 0.31 10.3 0.0 1.2 1 0 0 1 1 1 0 SabA N-terminal extracellular adhesion domain DnaJ_CXXCXGXG PF00684.19 EDO05190.1 - 0.37 11.2 2.5 0.71 10.3 2.5 1.4 1 0 0 1 1 1 0 DnaJ central domain GatB_N PF02934.15 EDO05193.1 - 1.8e-50 171.9 0.0 1.4e-46 159.1 0.0 2.1 2 0 0 2 2 2 2 GatB/GatE catalytic domain GatB_Yqey PF02637.18 EDO05193.1 - 6.6e-05 22.8 0.0 0.00011 22.1 0.0 1.4 1 0 0 1 1 1 1 GatB domain MnmE_helical PF12631.7 EDO05194.1 - 1.1e-38 133.5 6.2 1.6e-38 133.0 6.2 1.3 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 EDO05194.1 - 2.4e-32 111.7 0.1 7.2e-32 110.1 0.1 1.9 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 EDO05194.1 - 1.9e-23 82.7 1.1 3.7e-23 81.8 0.2 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDO05194.1 - 2.4e-13 49.9 1.9 4.6e-13 49.0 1.9 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EDO05194.1 - 1.2e-08 35.2 6.9 0.00087 19.4 0.0 3.2 3 1 1 4 4 3 2 Dynamin family RsgA_GTPase PF03193.16 EDO05194.1 - 3.6e-07 30.2 4.5 0.0039 17.1 0.0 3.1 2 2 1 3 3 3 2 RsgA GTPase Gtr1_RagA PF04670.12 EDO05194.1 - 7.4e-06 25.5 1.9 8.4e-06 25.3 0.3 1.9 2 1 0 2 2 2 1 Gtr1/RagA G protein conserved region Roc PF08477.13 EDO05194.1 - 7e-05 23.0 0.1 0.007 16.6 0.1 2.8 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 EDO05194.1 - 0.00027 20.3 1.0 0.00062 19.1 0.9 1.7 1 1 0 1 1 1 1 AIG1 family ABC_tran PF00005.27 EDO05194.1 - 0.00069 20.1 1.4 0.0015 19.0 0.4 2.2 1 1 1 2 2 2 1 ABC transporter AAA_23 PF13476.6 EDO05194.1 - 0.0013 19.2 0.5 0.0013 19.2 0.5 1.9 2 0 0 2 2 2 1 AAA domain Septin PF00735.18 EDO05194.1 - 0.0036 16.6 1.8 0.3 10.3 1.8 2.4 1 1 0 1 1 1 1 Septin AAA PF00004.29 EDO05194.1 - 0.025 15.0 0.6 0.21 12.0 0.0 2.5 1 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) cobW PF02492.19 EDO05194.1 - 0.042 13.4 1.0 5.7 6.5 0.0 2.7 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain GIT1_C PF12205.8 EDO05194.1 - 0.062 13.4 2.4 2.5 8.2 0.3 2.7 1 1 1 2 2 2 0 G protein-coupled receptor kinase-interacting protein 1 C term AAA_24 PF13479.6 EDO05194.1 - 0.07 12.8 1.1 0.32 10.7 1.1 2.1 1 1 0 1 1 1 0 AAA domain Nuc_deoxyri_tr2 PF15891.5 EDO05194.1 - 0.15 12.4 0.4 0.55 10.6 0.1 2.1 3 0 0 3 3 1 0 Nucleoside 2-deoxyribosyltransferase like HEPN_RES_NTD1 PF18870.1 EDO05194.1 - 0.46 10.7 1.8 0.91 9.7 0.2 2.3 2 0 0 2 2 2 0 HEPN/RES N-terminal domain 1 Kei1 PF08552.11 EDO05195.1 - 0.027 14.4 0.8 0.036 13.9 0.8 1.3 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 ThiF PF00899.21 EDO05196.1 - 9.3e-45 152.9 1.3 1.3e-44 152.4 1.3 1.1 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 EDO05196.1 - 5.6e-05 23.2 0.1 0.00013 22.1 0.1 1.6 1 0 0 1 1 1 1 E2 binding domain Shikimate_DH PF01488.20 EDO05196.1 - 0.028 14.5 0.7 0.028 14.5 0.7 4.0 3 1 1 4 4 4 0 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.21 EDO05196.1 - 0.033 13.5 2.9 0.053 12.8 0.3 2.3 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 EDO05196.1 - 0.26 11.6 4.1 0.16 12.3 1.4 2.1 2 1 0 2 2 2 0 TrkA-N domain Pyr_redox PF00070.27 EDO05196.1 - 0.54 10.8 3.0 0.47 11.1 0.5 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase PglD_N PF17836.1 EDO05196.1 - 2.9 8.6 7.5 1.5 9.5 3.1 2.9 3 1 0 3 3 3 0 PglD N-terminal domain Sacchrp_dh_NADP PF03435.18 EDO05196.1 - 4.4 7.6 12.5 0.1 12.9 1.5 3.0 4 1 0 4 4 4 0 Saccharopine dehydrogenase NADP binding domain DUF3546 PF12066.8 EDO05197.1 - 6.6e-10 39.2 4.2 1.5e-09 38.0 4.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3546) ARS2 PF04959.13 EDO05197.1 - 3.5e-05 24.3 0.5 8.5e-05 23.0 0.5 1.6 1 0 0 1 1 1 1 Arsenite-resistance protein 2 DUF4187 PF13821.6 EDO05197.1 - 0.0001 22.0 0.0 0.00024 20.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) Zf_RING PF16744.5 EDO05197.1 - 0.019 15.1 2.1 0.019 15.1 2.1 2.0 2 0 0 2 2 2 0 KIAA1045 RING finger zf-C2H2_4 PF13894.6 EDO05197.1 - 0.089 13.7 2.1 0.39 11.7 2.1 2.2 1 0 0 1 1 1 0 C2H2-type zinc finger Actin_micro PF17003.5 EDO05197.1 - 0.098 11.8 0.4 0.17 11.1 0.4 1.3 1 0 0 1 1 1 0 Putative actin-like family zf-C2H2 PF00096.26 EDO05197.1 - 7.2 7.3 7.2 0.67 10.5 1.8 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type CheR PF01739.18 EDO05200.1 - 0.026 14.0 0.0 0.036 13.5 0.0 1.2 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain TBPIP PF07106.13 EDO05201.1 - 0.087 12.8 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 TBPIP/Hop2 winged helix domain SDA1 PF05285.12 EDO05202.1 - 3.7e-05 23.3 9.1 4.4e-05 23.1 9.1 1.3 1 0 0 1 1 1 1 SDA1 BUD22 PF09073.10 EDO05202.1 - 6.5e-05 22.5 6.3 7.2e-05 22.3 6.3 1.2 1 0 0 1 1 1 1 BUD22 DUF3391 PF11871.8 EDO05202.1 - 0.00059 20.4 0.6 0.00059 20.4 0.6 1.8 2 1 0 2 2 1 1 Domain of unknown function (DUF3391) Zip PF02535.22 EDO05202.1 - 0.00078 18.8 0.5 0.0011 18.2 0.5 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter SpoIIP PF07454.11 EDO05202.1 - 0.0012 18.4 2.8 0.0014 18.1 2.8 1.2 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) DUF913 PF06025.12 EDO05202.1 - 0.004 16.2 2.1 0.0059 15.6 2.1 1.3 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) DUF5523 PF17661.1 EDO05202.1 - 0.0047 16.6 14.2 0.008 15.9 14.2 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5523) TRAP_alpha PF03896.16 EDO05202.1 - 0.0048 16.2 5.1 0.0075 15.5 5.1 1.3 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit CPSF100_C PF13299.6 EDO05202.1 - 0.0059 16.8 4.6 0.0097 16.1 4.6 1.4 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal RNA_pol_Rpc4 PF05132.14 EDO05202.1 - 0.011 16.2 2.8 0.011 16.2 2.8 1.6 2 0 0 2 2 1 0 RNA polymerase III RPC4 Presenilin PF01080.17 EDO05202.1 - 0.012 14.4 0.3 0.012 14.4 0.3 1.2 1 0 0 1 1 1 0 Presenilin DNA_pol_phi PF04931.13 EDO05202.1 - 0.016 13.3 18.4 0.029 12.5 18.4 1.3 1 0 0 1 1 1 0 DNA polymerase phi NPR3 PF03666.13 EDO05202.1 - 0.019 13.7 0.8 0.023 13.5 0.8 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 AIF_C PF14721.6 EDO05202.1 - 0.02 15.3 1.6 0.039 14.3 1.6 1.4 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term V_ATPase_I PF01496.19 EDO05202.1 - 0.026 12.5 2.4 0.032 12.2 2.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Connexin PF00029.19 EDO05202.1 - 0.028 14.2 4.2 0.042 13.6 4.2 1.2 1 0 0 1 1 1 0 Connexin RPN2_C PF18004.1 EDO05202.1 - 0.033 14.1 11.0 0.053 13.4 11.0 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Pox_Ag35 PF03286.14 EDO05202.1 - 0.035 13.9 12.9 0.065 13.0 12.9 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein U1snRNP70_N PF12220.8 EDO05202.1 - 0.037 14.7 6.8 0.076 13.7 6.8 1.7 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal NARP1 PF12569.8 EDO05202.1 - 0.043 12.7 6.9 0.061 12.2 6.9 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF2052 PF09747.9 EDO05202.1 - 0.047 13.8 15.8 0.028 14.6 13.6 1.7 2 0 0 2 2 1 0 Coiled-coil domain containing protein (DUF2052) Afi1 PF07792.12 EDO05202.1 - 0.12 12.8 7.4 0.26 11.8 7.4 1.5 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking GNAT_acetyltr_2 PF13718.6 EDO05202.1 - 0.13 11.6 2.7 0.2 11.0 2.7 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase 2 MDM10 PF12519.8 EDO05202.1 - 0.13 11.1 0.2 0.14 11.0 0.2 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Paf1 PF03985.13 EDO05202.1 - 0.15 11.1 19.3 0.2 10.6 19.3 1.2 1 0 0 1 1 1 0 Paf1 PEX11 PF05648.14 EDO05202.1 - 0.15 11.5 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) Fmp27 PF10344.9 EDO05202.1 - 0.15 10.1 5.6 0.48 8.4 5.3 1.8 2 0 0 2 2 2 0 Mitochondrial protein from FMP27 RR_TM4-6 PF06459.12 EDO05202.1 - 0.17 11.7 12.8 0.25 11.1 12.8 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PPL5 PF18168.1 EDO05202.1 - 0.18 11.1 6.6 0.29 10.4 6.6 1.3 1 0 0 1 1 1 0 Prim-pol family 5 RRN3 PF05327.11 EDO05202.1 - 0.18 10.3 13.5 0.27 9.7 13.5 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DDHD PF02862.17 EDO05202.1 - 0.21 11.7 4.4 0.68 10.0 4.9 1.3 1 1 0 1 1 1 0 DDHD domain SMN PF06003.12 EDO05202.1 - 0.22 10.7 3.6 43 3.2 6.5 2.1 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) RPA43_OB PF17875.1 EDO05202.1 - 0.31 11.7 4.8 0.72 10.5 4.8 1.6 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I Tim54 PF11711.8 EDO05202.1 - 0.34 9.7 8.8 0.49 9.1 8.8 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Nop14 PF04147.12 EDO05202.1 - 0.46 8.6 19.7 0.62 8.2 19.7 1.1 1 0 0 1 1 1 0 Nop14-like family FAM176 PF14851.6 EDO05202.1 - 0.47 10.1 11.7 1.5 8.5 11.7 1.8 1 0 0 1 1 1 0 FAM176 family PPP4R2 PF09184.11 EDO05202.1 - 0.62 9.6 18.3 1.1 8.8 18.3 1.4 1 0 0 1 1 1 0 PPP4R2 SID-1_RNA_chan PF13965.6 EDO05202.1 - 0.65 8.3 1.6 0.76 8.1 1.6 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Vfa1 PF08432.10 EDO05202.1 - 0.7 10.2 13.0 1.2 9.4 13.0 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF1682 PF07946.14 EDO05202.1 - 0.75 8.9 12.9 1.1 8.4 12.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Peptidase_S49_N PF08496.10 EDO05202.1 - 0.82 9.7 7.3 1.4 9.0 7.3 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Serinc PF03348.15 EDO05202.1 - 1 8.2 2.4 1.3 7.9 2.4 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Usp PF00582.26 EDO05202.1 - 1.3 9.6 6.9 2.9 8.4 6.9 1.6 1 0 0 1 1 1 0 Universal stress protein family TFIIF_alpha PF05793.12 EDO05202.1 - 1.5 7.4 23.7 2.1 6.8 23.7 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Coilin_N PF15862.5 EDO05202.1 - 1.6 8.5 11.2 2.9 7.7 11.2 1.4 1 0 0 1 1 1 0 Coilin N-terminus TFIIA PF03153.13 EDO05202.1 - 2.2 8.2 12.3 3 7.8 12.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FYDLN_acid PF09538.10 EDO05202.1 - 2.2 9.0 18.4 0.55 10.9 15.0 1.7 2 0 0 2 2 1 0 Protein of unknown function (FYDLN_acid) TFB6 PF17110.5 EDO05202.1 - 2.9 7.6 13.9 5.7 6.7 13.9 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH MDM31_MDM32 PF08118.11 EDO05202.1 - 3.3 6.3 5.8 5 5.7 5.8 1.3 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins TMEM119 PF15724.5 EDO05202.1 - 3.3 7.7 6.4 5.6 6.9 6.4 1.3 1 0 0 1 1 1 0 TMEM119 family NOA36 PF06524.12 EDO05202.1 - 3.4 6.9 16.8 5 6.4 16.8 1.2 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 EDO05202.1 - 3.5 5.8 18.0 4.8 5.3 18.0 1.1 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_3_Rpc31 PF11705.8 EDO05202.1 - 5.1 7.3 24.1 9.8 6.3 24.1 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 CobT PF06213.12 EDO05202.1 - 5.1 6.4 22.5 0.23 10.8 16.9 1.5 2 0 0 2 2 1 0 Cobalamin biosynthesis protein CobT DUF4820 PF16091.5 EDO05202.1 - 5.3 6.3 11.0 8.8 5.6 11.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF2722 PF10846.8 EDO05202.1 - 5.5 5.8 10.9 7.6 5.4 10.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) HA2 PF04408.23 EDO05202.1 - 6.1 7.2 6.0 2.9 8.2 3.4 1.8 2 0 0 2 2 1 0 Helicase associated domain (HA2) ATP-synt_E PF05680.12 EDO05202.1 - 7.5 7.0 12.5 19 5.7 12.5 1.6 1 0 0 1 1 1 0 ATP synthase E chain ORC_WH_C PF18137.1 EDO05202.1 - 8 6.5 13.1 16 5.5 13.1 1.4 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Ferlin_C PF16165.5 EDO05202.1 - 9.6 6.1 10.0 17 5.3 10.0 1.4 1 0 0 1 1 1 0 Ferlin C-terminus LapA_dom PF06305.11 EDO05203.1 - 0.85 9.5 17.0 1.9 8.4 0.2 4.7 4 0 0 4 4 4 0 Lipopolysaccharide assembly protein A domain LapA_dom PF06305.11 EDO05204.1 - 1 9.2 17.4 1.9 8.4 0.2 4.5 4 0 0 4 4 4 0 Lipopolysaccharide assembly protein A domain F-box-like_2 PF13013.6 EDO05205.1 - 1.8e-13 50.4 10.5 9.1e-06 25.6 0.5 3.5 1 1 2 3 3 3 3 F-box-like domain Band_7 PF01145.25 EDO05205.1 - 0.1 12.6 0.0 5.8 6.9 0.0 2.7 1 1 2 3 3 3 0 SPFH domain / Band 7 family F-box-like_2 PF13013.6 EDO05206.1 - 1.6e-05 24.8 0.1 2.4e-05 24.2 0.1 1.3 1 0 0 1 1 1 1 F-box-like domain VESA1_N PF12785.7 EDO05207.1 - 2.1e-123 412.7 6.4 1.7e-122 409.7 1.7 3.8 3 1 1 4 4 4 2 Variant erythrocyte surface antigen-1 F-box-like_2 PF13013.6 EDO05209.1 - 1.7e-07 31.2 0.6 4.2e-07 29.9 0.4 1.7 1 1 1 2 2 2 1 F-box-like domain DUF3484 PF11983.8 EDO05209.1 - 9.5 7.4 12.3 2.5e+02 2.9 7.9 3.2 1 1 1 2 2 2 0 Membrane-attachment and polymerisation-promoting switch F-box-like_2 PF13013.6 EDO05210.1 - 6.5e-10 38.9 2.2 4.9e-06 26.5 0.3 2.3 1 1 1 2 2 2 2 F-box-like domain DUF2076 PF09849.9 EDO05210.1 - 0.069 13.2 0.1 0.14 12.2 0.3 1.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) F-box-like_2 PF13013.6 EDO05211.1 - 2.6e-09 37.0 4.3 0.0042 17.0 0.0 3.2 2 1 1 3 3 3 3 F-box-like domain Methyltransf_FA PF12248.8 EDO05211.1 - 0.12 12.7 0.1 0.74 10.2 0.0 2.0 2 0 0 2 2 2 0 Farnesoic acid 0-methyl transferase VESA1_N PF12785.7 EDO05212.1 - 9.9e-11 41.3 0.1 1.1e-10 41.2 0.1 1.0 1 0 0 1 1 1 1 Variant erythrocyte surface antigen-1 UbiA PF01040.18 EDO05214.1 - 0.0038 16.6 1.5 0.0038 16.6 1.5 1.8 2 0 0 2 2 2 1 UbiA prenyltransferase family DUF2207 PF09972.9 EDO05214.1 - 0.031 13.0 0.0 0.035 12.9 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Phage_holin_3_6 PF07332.11 EDO05214.1 - 1.3 9.1 8.9 0.16 12.0 4.6 1.6 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III FA_desaturase PF00487.24 EDO05214.1 - 3.8 7.3 7.4 0.53 10.1 2.8 1.7 1 1 1 2 2 2 0 Fatty acid desaturase Fer4_5 PF12801.7 EDO05215.1 - 0.021 14.8 2.1 0.021 14.8 2.1 4.5 5 0 0 5 5 5 0 4Fe-4S binding domain DUF3671 PF12420.8 EDO05215.1 - 0.88 9.7 9.9 16 5.6 4.0 3.2 2 1 1 3 3 3 0 Protein of unknown function Baculo_11_kDa PF06143.11 EDO05215.1 - 3.8 7.2 10.4 9.4 5.9 2.5 3.2 3 0 0 3 3 3 0 Baculovirus 11 kDa family VESA1_N PF12785.7 EDO05216.1 - 3.3e-13 49.4 12.3 9.9e-11 41.3 8.1 2.1 1 1 1 2 2 2 2 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO05217.1 - 7.6e-219 727.3 18.5 7.6e-219 727.3 18.5 2.1 2 0 0 2 2 2 1 Variant erythrocyte surface antigen-1 I_LWEQ PF01608.17 EDO05217.1 - 0.055 13.7 0.3 0.055 13.7 0.3 2.2 2 1 0 2 2 2 0 I/LWEQ domain Collagen_mid PF15984.5 EDO05217.1 - 0.1 12.4 2.9 2.3 7.9 0.8 2.5 1 1 1 2 2 2 0 Bacterial collagen, middle region RRF PF01765.19 EDO05217.1 - 0.44 10.5 1.6 0.53 10.2 0.1 1.8 2 0 0 2 2 2 0 Ribosome recycling factor VESA1_N PF12785.7 EDO05218.1 - 2.6e-08 33.3 2.6 8.3e-08 31.6 0.2 2.0 1 1 1 2 2 2 2 Variant erythrocyte surface antigen-1 DUF2070 PF09843.9 EDO05219.1 - 0.0009 17.7 11.3 0.0012 17.3 11.3 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2070) EphA2_TM PF14575.6 EDO05219.1 - 0.49 11.3 3.1 15 6.6 0.0 3.1 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Flavi_NS4A PF01350.17 EDO05219.1 - 2.6 8.0 10.0 0.29 11.1 1.5 2.8 3 0 0 3 3 3 0 Flavivirus non-structural protein NS4A AsmA PF05170.14 EDO05219.1 - 4.9 5.8 5.2 4.7 5.9 0.4 2.0 2 0 0 2 2 2 0 AsmA family SPC25 PF06703.11 EDO05219.1 - 6.2 6.6 8.7 3.7 7.3 0.1 2.7 1 1 1 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF3357 PF11837.8 EDO05219.1 - 7.6 7.0 6.8 56 4.2 1.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3357) Glucos_trans_II PF14264.6 EDO05220.1 - 0.003 17.0 0.1 0.0036 16.7 0.1 1.1 1 0 0 1 1 1 1 Glucosyl transferase GtrII Sulfate_transp PF00916.20 EDO05220.1 - 0.0066 15.3 0.0 0.0096 14.7 0.0 1.2 1 0 0 1 1 1 1 Sulfate permease family DUF2207 PF09972.9 EDO05220.1 - 0.0069 15.2 0.0 0.0082 15.0 0.0 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF4191 PF13829.6 EDO05220.1 - 0.052 12.9 0.2 0.091 12.1 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) TraE PF05309.11 EDO05220.1 - 0.072 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 TraE protein TMCCDC2 PF15844.5 EDO05220.1 - 0.073 13.0 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 Transmembrane and coiled-coil domain-containing protein 2 TadE PF07811.12 EDO05220.1 - 0.35 11.2 8.6 1.1 9.5 0.0 3.1 3 0 0 3 3 3 0 TadE-like protein DUF4519 PF15012.6 EDO05220.1 - 3.9 7.7 4.7 1.5 9.1 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4519) F-box-like_2 PF13013.6 EDO05221.1 - 6.3e-06 26.1 0.8 0.005 16.8 0.1 2.2 1 1 1 2 2 2 2 F-box-like domain DUF4276 PF14103.6 EDO05221.1 - 0.12 12.6 0.2 0.23 11.7 0.1 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4276) PsbH PF00737.20 EDO05222.1 - 8.4 6.2 0.0 8.4 6.2 0.0 4.5 7 0 0 7 7 7 0 Photosystem II 10 kDa phosphoprotein TctB PF07331.11 EDO05223.1 - 0.0063 16.8 0.2 0.0084 16.4 0.2 1.1 1 0 0 1 1 1 1 Tripartite tricarboxylate transporter TctB family FeoB_associated PF12669.7 EDO05223.1 - 0.018 15.5 7.1 0.37 11.2 0.7 2.3 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein DUF4134 PF13572.6 EDO05223.1 - 0.02 15.2 1.0 0.029 14.7 0.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4134) Phage_holin_3_6 PF07332.11 EDO05223.1 - 0.025 14.6 0.1 0.025 14.6 0.1 1.5 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Oxidored_q3 PF00499.20 EDO05223.1 - 0.06 13.1 1.5 0.52 10.0 0.9 1.9 1 1 1 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Flp1_like PF16982.5 EDO05223.1 - 0.49 9.8 5.1 5.5 6.5 1.6 2.4 2 0 0 2 2 2 0 Putative Flagellin, Flp1-like, domain DUF2768 PF10966.8 EDO05223.1 - 0.95 10.0 8.1 2.8 8.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2768) EphA2_TM PF14575.6 EDO05223.1 - 1.3 9.9 5.8 21 6.1 5.8 2.2 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain FixQ PF05545.11 EDO05223.1 - 6.3 6.9 5.1 10 6.2 0.1 2.8 3 0 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ CoA_binding_3 PF13727.6 EDO05224.1 - 0.34 10.9 4.8 0.19 11.7 0.6 2.3 2 0 0 2 2 2 0 CoA-binding domain VESA1_N PF12785.7 EDO05225.1 - 1.1e-18 67.5 10.5 3.2e-10 39.6 0.0 5.0 5 1 1 6 6 6 3 Variant erythrocyte surface antigen-1 F-box-like_2 PF13013.6 EDO05226.1 - 2.5e-15 56.3 6.6 5.9e-05 23.0 0.2 3.8 2 1 2 4 4 4 4 F-box-like domain VESA1_N PF12785.7 EDO05227.1 - 4.1e-225 748.0 19.7 4.1e-225 748.0 19.7 3.4 4 0 0 4 4 4 1 Variant erythrocyte surface antigen-1 SCAB_CC PF16712.5 EDO05227.1 - 0.093 12.6 0.4 0.21 11.4 0.4 1.5 1 0 0 1 1 1 0 Coiled-coil regions of plant-specific actin-binding protein DDE_Tnp_1_assoc PF13808.6 EDO05227.1 - 0.13 12.3 0.0 0.51 10.4 0.0 2.0 1 0 0 1 1 1 0 DDE_Tnp_1-associated ALIX_LYPXL_bnd PF13949.6 EDO05227.1 - 0.15 11.4 0.0 0.27 10.5 0.0 1.4 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV VESA1_N PF12785.7 EDO05228.1 - 1.1e-210 700.4 22.8 1.1e-210 700.4 22.8 3.0 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 DUF745 PF05335.13 EDO05228.1 - 0.0079 15.9 1.5 0.0079 15.9 1.5 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF745) HemX PF04375.14 EDO05228.1 - 0.17 11.2 2.0 1.6 7.9 0.0 2.1 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Snapin_Pallidin PF14712.6 EDO05228.1 - 0.91 10.0 5.3 3.3 8.2 0.1 2.9 2 1 1 3 3 3 0 Snapin/Pallidin Baculo_PEP_C PF04513.12 EDO05228.1 - 1.4 9.0 6.1 0.7 9.9 0.9 3.1 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus NPV_P10 PF05531.12 EDO05228.1 - 3.6 8.1 4.9 1.2 9.6 0.7 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein SesA PF17107.5 EDO05228.1 - 4.1 7.6 6.0 7 6.9 0.3 2.8 2 1 1 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Spc7 PF08317.11 EDO05228.1 - 9.3 5.0 10.7 0.63 8.9 5.0 1.8 2 0 0 2 2 2 0 Spc7 kinetochore protein RRM_1 PF00076.22 EDO05229.1 - 1.2e-14 53.9 0.0 2.2e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Succ_DH_flav_C PF02910.20 EDO05229.1 - 0.058 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Fumarate reductase flavoprotein C-term DUF4144 PF13642.6 EDO05229.1 - 0.1 13.2 0.0 0.22 12.1 0.0 1.6 1 0 0 1 1 1 0 protein structure with unknown function RAP PF08373.10 EDO05230.1 - 5.6e-16 58.4 0.3 1.5e-15 57.0 0.3 1.8 1 0 0 1 1 1 1 RAP domain MTES_1575 PF18741.1 EDO05230.1 - 0.00057 20.0 0.6 0.0012 18.9 0.6 1.6 1 0 0 1 1 1 1 REase_MTES_1575 FAST_1 PF06743.15 EDO05230.1 - 0.01 15.8 0.1 0.038 13.9 0.0 2.1 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 Apis_Csd PF11671.8 EDO05230.1 - 0.042 13.9 0.0 0.042 13.9 0.0 1.9 2 0 0 2 2 2 0 Complementary sex determiner protein A_deaminase PF00962.22 EDO05231.1 - 2.1e-43 148.9 0.0 2.6e-43 148.6 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase ER PF01133.17 EDO05231.1 - 0.077 13.0 0.3 0.17 11.9 0.3 1.5 1 0 0 1 1 1 0 Enhancer of rudimentary Proteasome PF00227.26 EDO05232.1 - 2.2e-52 177.3 0.0 3e-52 176.9 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDO05232.1 - 3.1e-12 45.9 0.0 5.2e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature CLASP_N PF12348.8 EDO05233.1 - 0.00014 21.5 1.1 0.00024 20.7 1.1 1.4 1 1 0 1 1 1 1 CLASP N terminal SdrG_C_C PF10425.9 EDO05233.1 - 0.0057 16.8 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 C-terminus of bacterial fibrinogen-binding adhesin Cadherin-like PF12733.7 EDO05233.1 - 0.26 11.8 4.3 0.4 11.2 2.5 2.2 2 1 1 3 3 3 0 Cadherin-like beta sandwich domain Ribosomal_L33 PF00471.20 EDO05235.1 - 0.00065 20.1 0.1 0.0016 18.9 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L33 Sad1_UNC PF07738.13 EDO05236.1 - 1.3e-12 47.9 0.2 2.6e-12 46.9 0.2 1.6 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Sec63 PF02889.16 EDO05237.1 - 2.7e-65 220.1 10.8 1.3e-30 106.4 0.9 3.3 3 0 0 3 3 3 3 Sec63 Brl domain DEAD PF00270.29 EDO05237.1 - 7.5e-51 172.4 0.5 1.4e-26 93.3 0.2 3.6 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.15 EDO05237.1 - 1.9e-29 102.8 0.1 1.2e-13 51.5 0.0 2.9 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDO05237.1 - 7.9e-19 68.0 2.1 6.8e-09 36.1 0.3 3.6 2 1 0 2 2 2 2 Helicase conserved C-terminal domain AAA_19 PF13245.6 EDO05237.1 - 3.5e-08 33.9 0.2 0.028 14.7 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.6 EDO05237.1 - 4.7e-07 30.2 7.4 0.079 13.2 0.1 5.3 5 2 0 5 5 5 2 AAA domain AAA PF00004.29 EDO05237.1 - 5.9e-07 30.0 0.3 0.038 14.4 0.3 3.5 2 2 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 EDO05237.1 - 7.9e-06 25.5 0.1 0.15 11.5 0.1 2.6 2 0 0 2 2 2 2 PhoH-like protein T2SSE PF00437.20 EDO05237.1 - 0.0001 21.5 0.0 0.39 9.7 0.0 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_11 PF13086.6 EDO05237.1 - 0.014 15.2 0.3 0.45 10.3 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 EDO05237.1 - 0.03 13.8 0.1 10 5.6 0.0 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region UvrD-helicase PF00580.21 EDO05237.1 - 0.043 13.3 0.1 46 3.4 0.0 3.5 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain AAA_16 PF13191.6 EDO05237.1 - 0.047 14.1 0.1 14 6.1 0.0 3.2 4 0 0 4 4 4 0 AAA ATPase domain CBFD_NFYB_HMF PF00808.23 EDO05238.1 - 1.7e-16 60.2 0.1 2.6e-16 59.7 0.1 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDO05238.1 - 5.9e-12 46.1 0.0 1e-11 45.3 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 EDO05238.1 - 0.18 12.0 0.3 0.44 10.7 0.1 1.6 1 1 0 1 1 1 0 TATA box binding protein associated factor (TAF) Pkinase PF00069.25 EDO05240.1 - 7.2e-35 120.6 0.0 5e-19 68.7 0.0 2.5 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO05240.1 - 1.1e-12 47.8 0.0 8.2e-06 25.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EDO05240.1 - 0.0049 16.2 0.0 3 7.1 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 EDO05240.1 - 0.016 14.5 0.0 0.029 13.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pro-MCH PF05824.12 EDO05243.1 - 0.022 14.7 0.0 0.024 14.6 0.0 1.1 1 0 0 1 1 1 0 Pro-melanin-concentrating hormone (Pro-MCH) PPR_2 PF13041.6 EDO05244.1 - 5.2e-39 132.2 7.1 8.3e-11 41.9 0.0 6.8 4 1 3 7 7 7 6 PPR repeat family PPR_3 PF13812.6 EDO05244.1 - 4.6e-30 103.5 3.1 4.7e-07 29.8 0.0 6.5 7 0 0 7 7 7 5 Pentatricopeptide repeat domain PPR PF01535.20 EDO05244.1 - 8e-24 82.2 13.0 3.3e-05 23.8 0.1 8.3 8 1 0 8 8 8 5 PPR repeat PPR_long PF17177.4 EDO05244.1 - 5.1e-23 81.6 0.5 3.4e-14 52.7 0.0 4.0 1 1 3 4 4 4 3 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EDO05244.1 - 2.5e-16 59.0 0.2 0.0039 16.8 0.0 7.4 7 0 0 7 7 7 3 PPR repeat RPM2 PF08579.11 EDO05244.1 - 1.5e-07 31.8 0.3 0.095 13.1 0.0 5.0 3 2 2 5 5 5 1 Mitochondrial ribonuclease P subunit (RPM2) ECSIT PF06239.11 EDO05244.1 - 0.0009 18.4 0.0 0.058 12.5 0.0 3.6 5 0 0 5 5 5 1 Evolutionarily conserved signalling intermediate in Toll pathway ATP13 PF12921.7 EDO05244.1 - 0.0057 16.5 0.6 12 5.8 0.0 4.3 3 1 1 4 4 4 1 Mitochondrial ATPase expression Kri1_C PF12936.7 EDO05244.1 - 0.13 12.4 0.8 1.1 9.5 0.4 2.3 2 0 0 2 2 2 0 KRI1-like family C-terminal DUF3994 PF13159.6 EDO05245.1 - 0.031 14.8 2.1 0.065 13.8 2.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3994) YtxH PF12732.7 EDO05245.1 - 3.8 8.1 7.1 8.4 7.0 0.3 2.8 3 1 0 3 3 3 0 YtxH-like protein RIBIOP_C PF04950.12 EDO05246.1 - 6.9e-97 324.4 0.0 1.1e-96 323.8 0.0 1.3 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EDO05246.1 - 2.1e-11 43.7 0.0 9e-11 41.7 0.0 2.2 1 0 0 1 1 1 1 AARP2CN (NUC121) domain CLAG PF03805.13 EDO05247.1 - 2.2e-15 55.4 0.3 3.3e-11 41.6 0.2 2.2 2 0 0 2 2 2 2 Cytoadherence-linked asexual protein DUF3292 PF11696.8 EDO05247.1 - 0.13 10.6 0.0 0.13 10.6 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3292) LRR_4 PF12799.7 EDO05248.1 - 4.9e-38 128.5 69.1 9.3e-08 32.3 3.5 6.5 2 2 7 9 9 9 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDO05248.1 - 1.6e-21 75.9 36.3 1.3e-07 31.3 2.2 5.7 1 1 4 5 5 5 5 Leucine rich repeat LRR_9 PF14580.6 EDO05248.1 - 2.1e-10 40.4 22.6 7.5e-05 22.3 4.4 3.8 2 1 1 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 EDO05248.1 - 3.8e-05 23.7 33.2 0.33 11.7 0.1 9.4 7 2 1 8 8 8 2 Leucine Rich Repeat LRR_6 PF13516.6 EDO05248.1 - 0.0013 18.7 43.3 0.19 11.9 0.1 9.2 11 0 0 11 11 11 4 Leucine Rich repeat LRR_2 PF07723.13 EDO05248.1 - 0.085 13.6 11.1 0.7 10.7 0.2 5.0 5 0 0 5 5 5 0 Leucine Rich Repeat CLU_N PF15044.6 EDO05248.1 - 0.19 12.1 2.5 0.91 9.9 0.5 2.7 2 1 0 2 2 2 0 Mitochondrial function, CLU-N-term GCV_T PF01571.21 EDO05249.1 - 4.7e-06 26.2 0.0 7e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain CelTOS PF18659.1 EDO05251.1 - 0.0045 17.4 0.1 0.0092 16.4 0.1 1.5 1 1 0 1 1 1 1 Cell-traversal protein for ookinetes and sporozoites TetR_C_19 PF17924.1 EDO05251.1 - 0.023 15.3 0.3 0.11 13.1 0.0 2.1 1 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain HMG_box PF00505.19 EDO05252.1 - 0.053 14.0 1.4 11 6.5 0.1 2.7 2 0 0 2 2 2 0 HMG (high mobility group) box DUF4342 PF14242.6 EDO05252.1 - 0.1 12.6 0.2 0.29 11.2 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4342) UvrD-helicase PF00580.21 EDO05252.1 - 0.11 12.0 2.3 0.14 11.6 2.3 1.1 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Dpoe2NT PF12213.8 EDO05252.1 - 0.12 12.6 0.1 0.61 10.4 0.0 2.2 2 0 0 2 2 2 0 DNA polymerases epsilon N terminal DUF2497 PF10691.9 EDO05252.1 - 0.17 12.3 3.7 4.9 7.6 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2497) TetR_C_19 PF17924.1 EDO05252.1 - 0.23 12.1 1.9 1.2 9.7 0.3 2.7 2 2 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain RecG_N PF17190.4 EDO05252.1 - 0.65 10.8 4.4 7.6 7.3 0.1 2.7 3 0 0 3 3 3 0 RecG N-terminal helical domain Hypoth_Ymh PF09509.10 EDO05253.1 - 0.097 12.6 0.0 0.26 11.2 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (Hypoth_ymh) AAA_lid_9 PF17871.1 EDO05254.1 - 1.6e-23 82.6 3.6 4.9e-23 81.0 0.0 2.5 2 0 0 2 2 2 1 AAA lid domain AAA PF00004.29 EDO05254.1 - 3.5e-21 76.0 0.0 2.3e-14 54.0 0.0 3.3 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDO05254.1 - 3.8e-11 43.7 0.5 1.9e-08 34.9 0.1 3.2 2 1 1 3 3 3 1 AAA ATPase domain TniB PF05621.11 EDO05254.1 - 4.3e-10 39.3 0.2 7.5e-05 22.2 0.0 2.6 2 0 0 2 2 2 2 Bacterial TniB protein AAA_2 PF07724.14 EDO05254.1 - 1.4e-09 38.3 0.0 1.1e-05 25.6 0.0 3.0 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EDO05254.1 - 2.5e-08 34.0 0.6 0.0019 18.2 0.2 3.8 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EDO05254.1 - 1.2e-07 31.6 0.3 0.00017 21.4 0.2 3.2 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EDO05254.1 - 4.8e-07 30.1 1.5 0.044 14.1 0.0 4.5 4 1 1 5 5 4 2 AAA domain AAA_7 PF12775.7 EDO05254.1 - 1.5e-06 27.9 0.1 2.6e-05 23.8 0.0 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 EDO05254.1 - 9.1e-06 25.5 0.1 0.00015 21.6 0.0 2.6 3 0 0 3 3 2 1 IstB-like ATP binding protein AAA_14 PF13173.6 EDO05254.1 - 1.2e-05 25.4 0.1 2.7e-05 24.2 0.1 1.7 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EDO05254.1 - 1.7e-05 24.8 2.4 5.2e-05 23.3 0.2 2.8 3 1 0 3 3 1 1 ATPase domain predominantly from Archaea RsgA_GTPase PF03193.16 EDO05254.1 - 0.0003 20.8 0.3 0.045 13.7 0.0 2.9 3 0 0 3 3 3 1 RsgA GTPase RNA_helicase PF00910.22 EDO05254.1 - 0.0013 19.1 0.0 0.25 11.8 0.0 2.7 2 0 0 2 2 2 1 RNA helicase NACHT PF05729.12 EDO05254.1 - 0.0017 18.3 0.0 0.031 14.2 0.0 2.9 3 0 0 3 3 3 1 NACHT domain Roc PF08477.13 EDO05254.1 - 0.0025 18.0 0.0 0.044 14.0 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Mg_chelatase PF01078.21 EDO05254.1 - 0.0039 16.6 0.6 0.22 10.9 0.0 2.8 3 1 0 3 3 2 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EDO05254.1 - 0.005 17.4 0.0 3 8.4 0.0 3.0 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 EDO05254.1 - 0.0059 16.6 0.0 0.056 13.4 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 EDO05254.1 - 0.0082 15.7 0.1 0.038 13.5 0.0 2.2 3 0 0 3 3 1 1 AAA domain MCM PF00493.23 EDO05254.1 - 0.014 14.5 0.0 0.42 9.7 0.0 2.4 2 0 0 2 2 2 0 MCM P-loop domain AAA_24 PF13479.6 EDO05254.1 - 0.02 14.7 0.1 0.14 11.9 0.0 2.4 3 0 0 3 3 2 0 AAA domain Zeta_toxin PF06414.12 EDO05254.1 - 0.021 14.1 0.0 0.8 8.9 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin Clp_N PF02861.20 EDO05254.1 - 0.022 14.9 0.0 0.53 10.5 0.0 2.6 2 0 0 2 2 2 0 Clp amino terminal domain, pathogenicity island component NTPase_1 PF03266.15 EDO05254.1 - 0.029 14.3 0.1 1.7 8.6 0.0 3.5 4 0 0 4 4 4 0 NTPase TIP49 PF06068.13 EDO05254.1 - 0.035 13.3 0.2 3.4 6.8 0.0 2.4 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_33 PF13671.6 EDO05254.1 - 0.037 14.2 0.0 1 9.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain Ploopntkinase3 PF18751.1 EDO05254.1 - 0.073 13.0 0.1 31 4.4 0.0 3.4 3 0 0 3 3 3 0 P-loop Nucleotide Kinase3 NB-ARC PF00931.22 EDO05254.1 - 0.075 12.2 0.1 0.46 9.6 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain ResIII PF04851.15 EDO05254.1 - 0.079 13.0 0.2 7 6.6 0.0 2.8 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EDO05254.1 - 0.087 13.2 0.1 1.6 9.1 0.0 2.6 2 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EDO05254.1 - 0.089 12.5 0.0 3.2 7.4 0.0 2.8 3 0 0 3 3 3 0 Sigma-54 interaction domain SRP54 PF00448.22 EDO05254.1 - 0.1 12.3 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_17 PF13207.6 EDO05254.1 - 0.11 13.0 0.0 22 5.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain Med4 PF10018.9 EDO05254.1 - 0.13 12.0 0.7 0.26 11.0 0.7 1.4 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 SesA PF17107.5 EDO05254.1 - 0.14 12.3 1.5 24 5.1 0.0 3.3 3 0 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases MeaB PF03308.16 EDO05254.1 - 0.15 11.0 0.0 0.54 9.2 0.0 1.9 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB SlyX PF04102.12 EDO05254.1 - 0.62 10.7 2.7 24 5.6 0.7 2.9 2 0 0 2 2 2 0 SlyX CDC37_N PF03234.14 EDO05255.1 - 1e-05 26.5 2.2 1e-05 26.5 2.2 2.0 3 0 0 3 3 3 1 Cdc37 N terminal kinase binding V-SNARE_C PF12352.8 EDO05256.1 - 3.3e-07 30.5 6.2 6.1e-07 29.6 1.8 2.5 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus DUF4407 PF14362.6 EDO05256.1 - 0.014 14.8 6.7 0.016 14.5 6.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Med30 PF11315.8 EDO05256.1 - 0.014 15.6 5.8 0.014 15.6 5.8 2.0 1 1 1 2 2 2 0 Mediator complex subunit 30 MRFAP1 PF15155.6 EDO05256.1 - 0.057 14.0 1.7 0.61 10.6 0.4 2.3 1 1 1 2 2 2 0 MORF4 family-associated protein1 DUF3053 PF11254.8 EDO05256.1 - 0.061 12.9 6.1 0.12 11.9 0.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3053) LMBR1 PF04791.16 EDO05256.1 - 0.076 11.9 5.6 0.098 11.5 5.6 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein ApoC-I PF04691.12 EDO05256.1 - 0.077 12.9 6.6 5.6 7.0 0.0 3.6 2 1 1 3 3 3 0 Apolipoprotein C-I (ApoC-1) DASH_Duo1 PF08651.10 EDO05256.1 - 0.099 12.4 11.8 0.1 12.4 0.4 2.8 2 1 0 2 2 2 0 DASH complex subunit Duo1 NPV_P10 PF05531.12 EDO05256.1 - 0.16 12.5 10.0 1.7 9.2 1.3 3.0 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 EDO05256.1 - 0.26 11.3 5.4 1.6 8.8 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DP PF08781.10 EDO05256.1 - 0.39 10.6 8.7 0.11 12.4 5.4 1.8 2 0 0 2 2 2 0 Transcription factor DP EMC3_TMCO1 PF01956.16 EDO05256.1 - 0.41 10.3 5.9 51 3.6 5.9 2.3 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Bcr-Abl_Oligo PF09036.10 EDO05256.1 - 0.45 10.6 0.1 0.45 10.6 0.1 3.1 3 1 0 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain BORCS7 PF16088.5 EDO05256.1 - 0.52 10.6 7.5 0.29 11.4 2.4 2.9 2 1 1 3 3 3 0 BLOC-1-related complex sub-unit 7 XhlA PF10779.9 EDO05256.1 - 0.57 10.4 9.2 2.3 8.5 1.0 2.9 2 0 0 2 2 2 0 Haemolysin XhlA T3SS_needle_E PF08988.10 EDO05256.1 - 0.6 10.3 9.6 5.2 7.3 0.6 3.2 3 0 0 3 3 3 0 Type III secretion system, cytoplasmic E component of needle DUF16 PF01519.16 EDO05256.1 - 1.1 9.8 15.0 0.26 11.8 2.8 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 FliD_N PF02465.18 EDO05256.1 - 1.5 9.6 7.3 5.3 7.8 6.1 2.4 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus PIEZO PF15917.5 EDO05256.1 - 2.4 7.6 7.5 1.7 8.1 5.9 1.5 1 1 0 1 1 1 0 Piezo V-SNARE PF05008.15 EDO05256.1 - 3.5 8.1 12.1 4.9 7.6 6.7 2.6 2 2 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Poty_PP PF08440.10 EDO05256.1 - 4.5 6.3 11.2 2.2 7.3 7.0 2.0 1 1 1 2 2 2 0 Potyviridae polyprotein SlyX PF04102.12 EDO05256.1 - 8.8 7.0 12.5 3.4 8.3 0.5 3.5 3 1 0 3 3 3 0 SlyX AdoHcyase PF05221.17 EDO05258.1 - 5.9e-86 288.3 0.0 7.3e-86 288.0 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 EDO05258.1 - 1.3e-60 204.2 0.8 1.8e-60 203.7 0.8 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EDO05258.1 - 5.7e-10 38.8 0.4 1e-09 38.0 0.4 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EDO05258.1 - 1.5e-06 27.9 0.3 2.3e-06 27.3 0.3 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 EDO05258.1 - 0.00092 19.5 0.2 0.0019 18.5 0.2 1.6 1 0 0 1 1 1 1 TrkA-N domain Shikimate_DH PF01488.20 EDO05258.1 - 0.0043 17.1 0.1 0.0088 16.1 0.1 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 EDO05258.1 - 0.0066 16.3 0.3 0.012 15.5 0.3 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 EDO05258.1 - 0.023 15.2 0.1 0.042 14.3 0.1 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding F420_oxidored PF03807.17 EDO05258.1 - 0.023 15.3 0.3 0.052 14.1 0.3 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent THF_DHG_CYH_C PF02882.19 EDO05258.1 - 0.025 13.9 0.1 0.19 11.1 0.1 2.1 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Phasin PF05597.11 EDO05261.1 - 0.11 12.5 6.4 0.11 12.5 3.4 2.1 1 1 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DegS PF05384.11 EDO05261.1 - 0.68 9.4 11.9 1.5 8.3 11.9 1.7 1 1 0 1 1 1 0 Sensor protein DegS DUF4047 PF13256.6 EDO05261.1 - 2 8.6 7.1 17 5.6 1.7 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4047) Myc-LZ PF02344.15 EDO05261.1 - 3.5 7.8 7.3 0.32 11.1 2.1 2.0 2 0 0 2 2 2 0 Myc leucine zipper domain GWT1 PF06423.12 EDO05262.1 - 0.0036 17.4 0.0 0.0083 16.3 0.0 1.6 1 0 0 1 1 1 1 GWT1 eIF3_subunit PF08597.10 EDO05263.1 - 5.5e-12 46.1 11.0 1.7e-11 44.5 8.4 1.9 1 1 1 2 2 2 1 Translation initiation factor eIF3 subunit DUF4795 PF16043.5 EDO05263.1 - 0.00015 21.5 2.2 0.00023 20.9 2.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4795) Corona_M PF01635.18 EDO05264.1 - 0.17 11.2 4.7 0.096 12.0 2.5 1.6 1 1 0 1 1 1 0 Coronavirus M matrix/glycoprotein DUF1218 PF06749.12 EDO05264.1 - 0.3 11.6 5.8 0.12 12.9 3.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) Histone PF00125.24 EDO05265.1 - 6.4e-52 175.4 2.7 7.1e-52 175.2 2.7 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EDO05265.1 - 0.00012 22.3 0.0 0.00019 21.8 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 EDO05265.1 - 0.00035 21.2 1.5 0.00042 20.9 1.5 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 EDO05265.1 - 0.00044 20.3 0.1 0.00087 19.4 0.1 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EDO05265.1 - 0.0058 16.9 0.1 0.012 15.9 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EDO05265.1 - 0.0078 16.3 0.1 0.015 15.3 0.0 1.5 2 0 0 2 2 2 1 Transcription initiation factor IID, 31kD subunit eIF3_subunit PF08597.10 EDO05267.1 - 5.5e-12 46.1 11.0 1.7e-11 44.5 8.4 1.9 1 1 1 2 2 2 1 Translation initiation factor eIF3 subunit DUF4795 PF16043.5 EDO05267.1 - 0.00015 21.5 2.2 0.00023 20.9 2.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4795) Histone PF00125.24 EDO05270.1 - 6.4e-52 175.4 2.7 7.1e-52 175.2 2.7 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EDO05270.1 - 0.00012 22.3 0.0 0.00019 21.8 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 EDO05270.1 - 0.00035 21.2 1.5 0.00042 20.9 1.5 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 EDO05270.1 - 0.00044 20.3 0.1 0.00087 19.4 0.1 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EDO05270.1 - 0.0058 16.9 0.1 0.012 15.9 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EDO05270.1 - 0.0078 16.3 0.1 0.015 15.3 0.0 1.5 2 0 0 2 2 2 1 Transcription initiation factor IID, 31kD subunit DUF2443 PF10398.9 EDO05271.1 - 0.15 12.2 6.9 9.6 6.3 0.1 4.3 3 1 0 3 3 3 0 Protein of unknown function (DUF2443) DUF4407 PF14362.6 EDO05271.1 - 4.7 6.5 43.1 13 5.0 0.1 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) Adaptin_N PF01602.20 EDO05272.1 - 6.2e-40 137.2 1.6 7.6e-40 136.9 1.6 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.6 EDO05272.1 - 0.00018 21.8 0.1 0.38 11.2 0.0 4.3 4 2 1 5 5 5 1 HEAT repeats HEAT_EZ PF13513.6 EDO05272.1 - 0.0025 18.3 2.0 0.032 14.8 0.0 3.4 4 0 0 4 4 4 1 HEAT-like repeat HEAT PF02985.22 EDO05272.1 - 0.0025 17.9 0.4 0.071 13.4 0.1 3.4 2 0 0 2 2 2 1 HEAT repeat Arm PF00514.23 EDO05272.1 - 0.1 12.7 1.8 0.45 10.6 0.0 3.2 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Synaptobrevin PF00957.21 EDO05274.1 - 1.2e-10 41.0 0.0 1.7e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EDO05274.1 - 0.00042 20.3 0.0 0.0011 18.9 0.0 1.7 1 1 0 1 1 1 1 Regulated-SNARE-like domain Aquarius_N PF16399.5 EDO05275.1 - 6.1e-129 431.4 3.4 2.8e-128 429.2 3.4 1.8 1 1 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_12 PF13087.6 EDO05275.1 - 3.3e-30 105.2 0.0 6.4e-30 104.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EDO05275.1 - 6.1e-22 78.7 0.0 5.2e-21 75.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDO05275.1 - 3.3e-06 27.5 0.0 1.2e-05 25.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDO05275.1 - 3.1e-05 23.8 0.0 0.089 12.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 EDO05275.1 - 7.2e-05 22.6 0.4 0.031 14.0 0.0 4.0 4 0 0 4 4 4 1 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.6 EDO05275.1 - 0.00018 21.2 0.0 0.00041 20.1 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_22 PF13401.6 EDO05275.1 - 0.044 14.1 0.0 0.82 9.9 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EDO05275.1 - 0.05 13.6 0.0 0.24 11.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 EDO05275.1 - 0.16 12.5 0.0 0.32 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EDO05275.1 - 0.25 10.5 0.8 0.45 9.7 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) ArsA_ATPase PF02374.15 EDO05277.1 - 2.7e-84 283.0 4.2 7.2e-78 261.8 0.7 2.2 1 1 0 2 2 2 2 Anion-transporting ATPase CbiA PF01656.23 EDO05277.1 - 2.6e-12 46.9 0.0 2.5e-11 43.8 0.0 2.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EDO05277.1 - 1.1e-09 38.5 0.0 3e-09 37.0 0.0 1.9 1 0 0 1 1 1 1 AAA domain CBP_BcsQ PF06564.12 EDO05277.1 - 6.7e-06 25.7 0.0 1.1e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ ParA PF10609.9 EDO05277.1 - 8.5e-06 25.4 0.1 4.6e-05 23.0 0.0 2.0 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase NB-ARC PF00931.22 EDO05277.1 - 7.9e-05 22.0 0.0 0.00016 20.9 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain Fer4_NifH PF00142.18 EDO05277.1 - 0.00026 20.6 0.0 0.00054 19.5 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.22 EDO05277.1 - 0.0017 18.0 0.2 0.043 13.4 0.0 2.2 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 EDO05277.1 - 0.0022 17.3 0.0 0.0045 16.3 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 EDO05277.1 - 0.0062 16.9 0.0 0.011 16.1 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain PIF1 PF05970.14 EDO05277.1 - 0.0067 15.6 0.2 0.027 13.6 0.0 2.0 2 1 1 3 3 3 1 PIF1-like helicase NACHT PF05729.12 EDO05277.1 - 0.0089 16.0 0.7 0.05 13.5 0.3 2.4 2 1 0 2 2 2 1 NACHT domain AAA_18 PF13238.6 EDO05277.1 - 0.035 14.6 0.2 0.56 10.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EDO05277.1 - 0.045 14.3 0.2 0.17 12.4 0.0 2.0 2 1 0 2 2 2 0 ABC transporter APS_kinase PF01583.20 EDO05277.1 - 0.064 13.2 0.1 0.28 11.1 0.1 2.1 1 1 1 2 2 2 0 Adenylylsulphate kinase AAA_25 PF13481.6 EDO05277.1 - 0.11 12.0 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDO05277.1 - 0.11 12.9 0.1 0.75 10.2 0.0 2.4 2 1 0 2 2 2 0 RNA helicase PhoH PF02562.16 EDO05277.1 - 0.12 11.9 0.0 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_30 PF13604.6 EDO05277.1 - 0.12 12.1 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EDO05277.1 - 0.14 12.1 0.2 0.35 10.8 0.2 1.7 1 0 0 1 1 1 0 NTPase ATP_bind_1 PF03029.17 EDO05277.1 - 0.83 9.4 4.5 0.52 10.1 0.8 2.6 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein Arm PF00514.23 EDO05278.1 - 3.6e-09 36.4 0.0 0.0008 19.4 0.0 4.4 4 1 0 4 4 4 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 EDO05278.1 - 0.087 13.2 0.7 5.3 7.5 0.0 2.9 2 1 0 2 2 2 0 HEAT repeats Atx10homo_assoc PF09759.9 EDO05278.1 - 0.098 12.7 0.0 0.29 11.2 0.0 1.8 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain Pkinase PF00069.25 EDO05279.1 - 3.8e-62 210.1 0.0 8.2e-62 208.9 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO05279.1 - 1.4e-27 96.6 0.0 2.2e-27 96.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDO05279.1 - 0.0015 17.6 0.1 0.17 10.8 0.0 2.3 2 0 0 2 2 2 2 Haspin like kinase domain Kinase-like PF14531.6 EDO05279.1 - 0.0032 16.8 0.0 0.0069 15.7 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Cortex-I_coil PF09304.10 EDO05280.1 - 0.13 12.5 6.6 0.043 14.0 2.2 2.3 2 0 0 2 2 2 0 Cortexillin I, coiled coil tRNA-synt_1g PF09334.11 EDO05281.1 - 1.2e-85 287.7 0.0 1.5e-51 175.4 0.0 2.1 1 1 1 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EDO05281.1 - 1.4e-30 106.1 0.6 2e-19 69.3 0.3 4.0 2 1 2 4 4 4 4 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EDO05281.1 - 1.2e-10 41.3 0.0 1.9e-06 27.5 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 EDO05281.1 - 3.5e-07 29.5 0.0 0.00029 19.9 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (K) Anticodon_1 PF08264.13 EDO05281.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Anticodon-binding domain of tRNA tRNA-synt_1b PF00579.25 EDO05281.1 - 0.16 11.2 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) MMR_HSR1 PF01926.23 EDO05284.1 - 9.2e-20 70.8 0.0 1.7e-19 70.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EDO05284.1 - 1.9e-05 24.8 0.0 0.011 15.8 0.0 2.3 1 1 1 2 2 2 2 Dynamin family FeoB_N PF02421.18 EDO05284.1 - 3.1e-05 23.6 0.0 4.5e-05 23.0 0.0 1.4 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EDO05284.1 - 6.5e-05 22.6 0.1 0.0019 17.8 0.1 2.4 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EDO05284.1 - 0.00035 20.5 0.2 0.7 9.8 0.0 2.8 3 1 0 3 3 3 2 RsgA GTPase ABC_tran PF00005.27 EDO05284.1 - 0.11 13.0 0.0 0.32 11.5 0.0 1.7 2 0 0 2 2 2 0 ABC transporter Evr1_Alr PF04777.13 EDO05285.1 - 1.3e-06 28.8 0.1 2e-06 28.2 0.1 1.3 1 0 0 1 1 1 1 Erv1 / Alr family CRAL_TRIO PF00650.20 EDO05286.1 - 2.7e-35 121.5 0.1 5.1e-35 120.6 0.0 1.5 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EDO05286.1 - 1.6e-05 25.1 0.0 2.7e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain TFIIS_M PF07500.14 EDO05288.1 - 7.3e-17 61.9 0.4 1.6e-16 60.8 0.4 1.6 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain TIC20 PF16166.5 EDO05289.1 - 0.038 13.8 0.9 0.047 13.5 0.9 1.1 1 0 0 1 1 1 0 Chloroplast import apparatus Tic20-like E1_dh PF00676.20 EDO05290.1 - 2.4e-54 184.3 0.0 3.5e-54 183.8 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component Transket_pyr PF02779.24 EDO05290.1 - 1.7e-50 171.2 0.0 2.8e-50 170.4 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 EDO05290.1 - 6.7e-38 129.8 0.0 1.1e-37 129.1 0.0 1.3 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal STI1 PF17830.1 EDO05293.1 - 0.064 13.2 0.0 0.092 12.7 0.0 1.3 1 0 0 1 1 1 0 STI1 domain CAP_C PF08603.11 EDO05293.1 - 0.095 12.3 0.1 0.14 11.8 0.1 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) C terminal HEAT_2 PF13646.6 EDO05294.1 - 3.2e-05 24.2 0.0 0.0001 22.6 0.0 2.0 1 1 0 1 1 1 1 HEAT repeats HEAT PF02985.22 EDO05294.1 - 0.044 14.1 0.0 21 5.7 0.0 3.3 3 0 0 3 3 3 0 HEAT repeat NolV PF06635.12 EDO05294.1 - 0.11 11.9 0.0 0.25 10.7 0.0 1.5 1 0 0 1 1 1 0 Nodulation protein NolV Trp_Tyr_perm PF03222.13 EDO05295.1 - 0.00014 21.1 11.3 0.0016 17.6 1.0 2.5 2 1 0 2 2 2 2 Tryptophan/tyrosine permease family Aa_trans PF01490.18 EDO05295.1 - 0.00019 20.3 15.6 0.00079 18.2 15.6 2.0 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein B12D PF06522.11 EDO05295.1 - 1.8 8.4 11.1 2.2 8.1 0.6 3.5 3 0 0 3 3 3 0 NADH-ubiquinone reductase complex 1 MLRQ subunit Arf PF00025.21 EDO05297.1 - 1.9e-67 226.1 0.3 2.1e-67 225.9 0.3 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EDO05297.1 - 2.1e-11 44.1 0.1 2.8e-11 43.7 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EDO05297.1 - 1.6e-10 40.7 2.1 1.6e-06 27.6 0.4 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EDO05297.1 - 6.8e-09 35.4 0.0 8.3e-09 35.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EDO05297.1 - 1.5e-08 34.3 0.0 2e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EDO05297.1 - 1.8e-08 34.4 0.0 2.7e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 EDO05297.1 - 7.1e-08 32.2 0.0 8.2e-08 32.0 0.0 1.1 1 0 0 1 1 1 1 Ras family GTP_EFTU PF00009.27 EDO05297.1 - 0.0039 16.7 0.1 0.032 13.8 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 EDO05297.1 - 0.009 16.5 0.4 0.027 15.0 0.4 1.7 1 1 0 1 1 1 1 ABC transporter cobW PF02492.19 EDO05297.1 - 0.038 13.6 0.3 0.19 11.3 0.1 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 EDO05297.1 - 0.15 11.8 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Tfb5 PF06331.12 EDO05298.1 - 7.6e-20 70.7 0.1 8.4e-20 70.5 0.1 1.1 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 SRA1 PF07304.11 EDO05298.1 - 0.068 12.9 0.0 0.079 12.8 0.0 1.1 1 0 0 1 1 1 0 Steroid receptor RNA activator (SRA1) SDA1 PF05285.12 EDO05299.1 - 4.3e-23 82.3 43.4 5.4e-17 62.2 12.8 2.7 2 1 1 3 3 3 2 SDA1 Cnd2 PF05786.14 EDO05300.1 - 1.2e-28 100.3 0.0 4.8e-20 71.8 0.2 2.3 2 0 0 2 2 2 2 Condensin complex subunit 2 CNDH2_N PF06278.11 EDO05300.1 - 0.0043 17.2 0.1 0.02 15.1 0.0 2.0 2 0 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Pyr_redox_2 PF07992.14 EDO05301.1 - 2.5e-51 174.7 0.0 3.4e-51 174.2 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EDO05301.1 - 7.4e-24 84.1 0.0 1.8e-23 82.9 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EDO05301.1 - 2.4e-19 69.7 0.8 1e-14 54.9 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDO05301.1 - 2.2e-08 33.7 0.2 1.8e-05 24.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EDO05301.1 - 3.4e-06 26.4 0.7 1.2e-05 24.6 0.3 1.9 2 0 0 2 2 2 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EDO05301.1 - 5.5e-06 25.8 0.1 0.0003 20.2 0.0 2.3 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 EDO05301.1 - 8.3e-06 25.1 0.4 3.4e-05 23.1 0.0 2.2 2 1 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 EDO05301.1 - 2.3e-05 24.0 0.4 3.4e-05 23.4 0.4 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EDO05301.1 - 0.00042 20.5 5.3 0.004 17.3 0.3 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EDO05301.1 - 0.00089 18.1 0.2 0.0021 16.8 0.2 1.7 1 0 0 1 1 1 1 HI0933-like protein K_oxygenase PF13434.6 EDO05301.1 - 0.0029 16.8 0.1 0.053 12.6 0.0 2.6 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EDO05301.1 - 0.0032 17.1 0.0 0.0077 15.9 0.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EDO05301.1 - 0.016 14.5 0.3 0.042 13.1 0.2 1.6 1 1 0 1 1 1 0 Thi4 family LMF1 PF06762.14 EDO05302.1 - 6e-94 315.7 0.5 6e-94 315.7 0.5 1.4 2 0 0 2 2 2 1 Lipase maturation factor Sec1 PF00995.23 EDO05303.1 - 2e-87 294.8 0.0 2.4e-87 294.5 0.0 1.0 1 0 0 1 1 1 1 Sec1 family RisS_PPD PF16524.5 EDO05305.1 - 0.018 15.3 0.0 0.059 13.6 0.0 1.9 1 0 0 1 1 1 0 Periplasmic domain of Sensor histidine kinase RisS Ribosomal_L18p PF00861.22 EDO05306.1 - 2.7e-21 76.1 1.2 2.2e-20 73.1 1.2 2.0 1 1 0 1 1 1 1 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast ANAPC_CDC26 PF10471.9 EDO05307.1 - 3.4 8.6 9.7 5.4 7.9 7.1 2.5 2 1 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Syntaxin-18_N PF10496.9 EDO05307.1 - 5.9 7.2 8.4 0.96 9.7 1.1 2.4 1 1 1 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus zf-RING_2 PF13639.6 EDO05309.1 - 6.5e-10 39.2 9.7 1.6e-09 37.9 9.7 1.7 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EDO05309.1 - 7.7e-06 26.1 8.0 2.2e-05 24.7 8.0 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EDO05309.1 - 2e-05 24.2 5.5 7.4e-05 22.4 5.3 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 EDO05309.1 - 2.7e-05 24.1 4.3 7.2e-05 22.7 4.3 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EDO05309.1 - 3e-05 23.8 8.8 7e-05 22.6 8.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDO05309.1 - 7.8e-05 22.6 10.0 0.00019 21.3 10.0 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EDO05309.1 - 0.00015 21.6 7.5 0.00042 20.1 7.5 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EDO05309.1 - 0.00043 20.3 3.8 0.0012 18.8 3.8 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EDO05309.1 - 0.0006 19.6 6.8 0.0014 18.5 6.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EDO05309.1 - 0.008 15.8 8.3 0.018 14.7 8.3 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 EDO05309.1 - 0.012 15.4 2.7 0.012 15.4 2.7 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING-like PF08746.11 EDO05309.1 - 0.028 14.7 10.4 0.085 13.2 10.4 1.9 1 0 0 1 1 1 0 RING-like domain zf-C3H2C3 PF17122.5 EDO05309.1 - 0.18 11.9 6.1 0.41 10.7 6.1 1.7 1 0 0 1 1 1 0 Zinc-finger zf-RING_4 PF14570.6 EDO05309.1 - 0.67 9.8 8.3 1.8 8.4 8.3 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain PHD PF00628.29 EDO05309.1 - 2.2 8.3 10.1 5.6 6.9 10.1 1.8 1 0 0 1 1 1 0 PHD-finger C1_2 PF03107.16 EDO05309.1 - 3 8.2 7.3 0.49 10.8 2.6 2.1 2 0 0 2 2 2 0 C1 domain DUF2053 PF09767.9 EDO05310.1 - 1.1e-34 119.9 5.1 1.4e-34 119.5 5.1 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2053) DJ-1_PfpI PF01965.24 EDO05311.1 - 4.2e-39 134.0 2.5 4.9e-39 133.8 2.5 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family CRAL_TRIO_2 PF13716.6 EDO05312.1 - 6e-28 97.7 0.6 9.9e-28 97.0 0.6 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain RhoGAP PF00620.27 EDO05312.1 - 1.5e-08 34.6 0.0 2.6e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain Filamin PF00630.19 EDO05313.1 - 0.0001 23.0 0.0 0.099 13.5 0.0 2.5 2 0 0 2 2 2 2 Filamin/ABP280 repeat Seryl_tRNA_N PF02403.22 EDO05313.1 - 0.14 12.4 0.9 0.57 10.4 0.5 2.0 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Vir_act_alpha_C PF10400.9 EDO05313.1 - 0.32 11.7 1.9 1.3 9.7 1.9 2.1 1 1 0 1 1 1 0 Virulence activator alpha C-term bZIP_Maf PF03131.17 EDO05313.1 - 1.1 9.8 3.4 0.76 10.3 0.8 2.0 1 1 0 2 2 2 0 bZIP Maf transcription factor AP2 PF00847.20 EDO05314.1 - 2e-10 40.7 2.1 5.7e-10 39.3 2.1 1.8 1 0 0 1 1 1 1 AP2 domain Flavodoxin_1 PF00258.25 EDO05315.1 - 6.2e-27 94.6 0.0 1.1e-26 93.7 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EDO05315.1 - 4.2e-14 53.1 0.0 1.8e-13 51.0 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_1 PF00667.20 EDO05315.1 - 1.4e-13 50.9 0.1 2.7e-13 50.0 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_binding_6 PF00970.24 EDO05315.1 - 0.014 15.7 0.2 0.085 13.2 0.0 2.2 2 1 0 2 2 2 0 Oxidoreductase FAD-binding domain gerPA PF10676.9 EDO05315.1 - 0.029 14.6 0.0 0.11 12.8 0.0 1.9 1 0 0 1 1 1 0 Spore germination protein gerPA/gerPF PAPS_reduct PF01507.19 EDO05316.1 - 6.5e-17 62.1 0.0 8.6e-11 42.2 0.0 2.1 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family RRM_1 PF00076.22 EDO05317.1 - 1.1e-15 57.2 0.0 1.8e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDO05317.1 - 0.016 14.8 0.1 0.079 12.6 0.0 1.8 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDO05317.1 - 0.078 13.0 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif CKS PF01111.19 EDO05318.1 - 1.2e-21 76.8 0.2 1.9e-21 76.1 0.2 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit Med29 PF11568.8 EDO05318.1 - 0.039 14.2 0.0 0.062 13.5 0.0 1.3 1 0 0 1 1 1 0 Mediator complex subunit 29 DUF4362 PF14275.6 EDO05319.1 - 0.024 14.9 0.1 0.049 13.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4362) DUF572 PF04502.13 EDO05321.1 - 8.2e-44 150.6 4.5 9.6e-44 150.3 4.5 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) NACHT PF05729.12 EDO05321.1 - 0.12 12.3 0.1 0.27 11.1 0.1 1.5 1 0 0 1 1 1 0 NACHT domain MMR_HSR1_C PF08438.10 EDO05321.1 - 0.4 11.3 2.7 2.7 8.6 2.7 2.2 1 1 0 1 1 1 0 GTPase of unknown function C-terminal tRNA-synt_1e PF01406.19 EDO05322.1 - 9e-119 396.3 0.1 1.3e-118 395.7 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EDO05322.1 - 6.4e-09 35.0 0.1 0.0023 16.7 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EDO05322.1 - 0.0015 16.9 0.0 0.0022 16.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1c PF00749.21 EDO05322.1 - 0.0099 14.8 0.0 0.028 13.3 0.0 1.8 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain PSD4 PF07631.11 EDO05322.1 - 0.11 13.0 0.9 0.32 11.6 0.9 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1592) FtsH_ext PF06480.15 EDO05325.1 - 0.11 12.9 0.7 0.13 12.6 0.7 1.2 1 0 0 1 1 1 0 FtsH Extracellular IMP2_N PF18590.1 EDO05326.1 - 3.9e-27 94.6 0.2 7.3e-27 93.7 0.2 1.5 1 0 0 1 1 1 1 Immune Mapped Protein 2 (IMP2) N-terminal domain 4HBT PF03061.22 EDO05329.1 - 1.2e-06 28.8 0.2 4.3e-06 27.0 0.2 1.9 1 1 0 1 1 1 1 Thioesterase superfamily CHCH PF06747.13 EDO05332.1 - 0.0036 17.4 0.2 0.0081 16.3 0.2 1.7 1 0 0 1 1 1 1 CHCH domain Urb2 PF10441.9 EDO05332.1 - 0.054 13.4 0.0 0.086 12.8 0.0 1.3 1 0 0 1 1 1 0 Urb2/Npa2 family Pet191_N PF10203.9 EDO05332.1 - 0.087 13.1 0.9 0.19 12.0 0.6 1.9 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 CS PF04969.16 EDO05333.1 - 5.4e-16 59.4 0.7 8.1e-16 58.8 0.7 1.3 1 0 0 1 1 1 1 CS domain HSP20 PF00011.21 EDO05333.1 - 0.13 12.4 0.2 0.69 10.1 0.1 2.0 1 1 1 2 2 2 0 Hsp20/alpha crystallin family Wax2_C PF12076.8 EDO05333.1 - 0.16 11.6 0.0 0.22 11.2 0.0 1.1 1 0 0 1 1 1 0 WAX2 C-terminal domain DUF3449 PF11931.8 EDO05335.1 - 1.3e-75 253.3 2.8 1.3e-75 253.3 2.8 2.8 3 1 0 3 3 3 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 EDO05335.1 - 8.8e-21 74.2 2.3 8.8e-21 74.2 2.3 3.9 3 1 0 3 3 3 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 SF3a60_bindingd PF12108.8 EDO05335.1 - 5.3e-06 26.2 1.5 0.00011 22.0 0.3 2.7 2 0 0 2 2 2 1 Splicing factor SF3a60 binding domain MIase PF02426.16 EDO05335.1 - 0.061 13.5 0.1 0.22 11.7 0.0 2.0 2 0 0 2 2 2 0 Muconolactone delta-isomerase zf-met PF12874.7 EDO05335.1 - 0.066 13.6 0.3 0.24 11.8 0.3 2.1 1 0 0 1 1 1 0 Zinc-finger of C2H2 type DUF5344 PF17279.2 EDO05335.1 - 0.1 13.2 7.3 3.9 8.1 0.4 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF5344) Desulfoferrod_N PF06397.12 EDO05335.1 - 0.26 11.0 0.9 0.49 10.0 0.9 1.4 1 0 0 1 1 1 0 Desulfoferrodoxin, N-terminal domain Imm51 PF15595.6 EDO05335.1 - 0.71 9.8 5.6 0.28 11.2 0.4 3.0 3 0 0 3 3 3 0 Immunity protein 51 Fumerase PF05681.14 EDO05336.1 - 3e-83 279.4 0.0 4.1e-83 278.9 0.0 1.2 1 0 0 1 1 1 1 Fumarate hydratase (Fumerase) Fumerase_C PF05683.12 EDO05336.1 - 4.6e-81 271.1 0.0 7.7e-81 270.3 0.0 1.4 1 0 0 1 1 1 1 Fumarase C-terminus IBN_N PF03810.19 EDO05336.1 - 0.019 14.9 0.0 0.041 13.8 0.0 1.5 1 0 0 1 1 1 0 Importin-beta N-terminal domain CECR6_TMEM121 PF14997.6 EDO05337.1 - 1.8e-06 27.9 10.3 0.0036 17.2 0.6 3.3 3 0 0 3 3 3 2 CECR6/TMEM121 family UIM PF02809.20 EDO05338.1 - 0.48 10.5 3.7 2 8.5 3.7 2.2 1 0 0 1 1 1 0 Ubiquitin interaction motif G-patch_2 PF12656.7 EDO05339.1 - 1.3e-15 57.2 0.0 2.7e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 G-patch domain UPF0086 PF01868.16 EDO05339.1 - 0.088 12.7 2.3 0.24 11.4 2.3 1.7 1 0 0 1 1 1 0 Domain of unknown function UPF0086 Lipin_N PF04571.14 EDO05339.1 - 0.09 12.8 1.4 0.32 11.0 0.1 2.1 2 0 0 2 2 2 0 lipin, N-terminal conserved region GCS PF03074.16 EDO05340.1 - 1.4e-109 366.8 0.7 1.8e-109 366.5 0.7 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase 2OG-FeII_Oxy_2 PF13532.6 EDO05341.1 - 2.3e-21 76.9 0.0 2.7e-21 76.6 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RNA_pol_A_bac PF01000.26 EDO05342.1 - 4.5e-22 78.6 0.0 2.4e-21 76.2 0.0 2.2 1 1 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EDO05342.1 - 3.3e-18 64.9 0.0 5.3e-18 64.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Dus PF01207.17 EDO05343.1 - 6.1e-58 196.3 0.0 7.5e-58 196.0 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 EDO05343.1 - 0.00021 20.8 0.0 0.0004 19.9 0.0 1.4 1 0 0 1 1 1 1 Histidine biosynthesis protein DUF86 PF01934.17 EDO05344.1 - 0.13 12.1 3.2 3.5 7.5 0.1 2.6 1 1 1 2 2 2 0 Protein of unknown function DUF86 CS PF04969.16 EDO05347.1 - 0.0014 19.6 0.5 0.0054 17.7 0.2 2.2 2 0 0 2 2 2 1 CS domain HD_5 PF13487.6 EDO05347.1 - 0.016 15.5 0.0 0.035 14.4 0.0 1.6 1 0 0 1 1 1 0 HD domain Siah-Interact_N PF09032.11 EDO05347.1 - 0.055 13.8 4.1 4.5 7.6 0.1 2.6 1 1 1 2 2 2 0 Siah interacting protein, N terminal RRF PF01765.19 EDO05347.1 - 0.082 12.9 1.2 0.13 12.2 1.2 1.4 1 0 0 1 1 1 0 Ribosome recycling factor Aminotran_5 PF00266.19 EDO05348.1 - 3.2e-83 279.7 0.0 4.9e-83 279.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EDO05348.1 - 2.3e-07 30.4 0.0 3.3e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EDO05348.1 - 4.9e-07 29.4 0.0 9.3e-07 28.5 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family DUF3369 PF11849.8 EDO05348.1 - 0.15 12.2 0.1 0.3 11.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3369) NuA4 PF09340.10 EDO05349.1 - 0.41 10.5 2.9 1.5 8.8 0.2 2.5 2 0 0 2 2 2 0 Histone acetyltransferase subunit NuA4 WSD PF15613.6 EDO05350.1 - 0.00027 21.3 1.3 0.012 16.0 1.3 2.9 1 1 0 1 1 1 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DNMT1-RFD PF12047.8 EDO05350.1 - 0.043 13.9 0.0 0.2 11.7 0.0 2.1 2 0 0 2 2 2 0 Cytosine specific DNA methyltransferase replication foci domain DUF3738 PF12543.8 EDO05352.1 - 0.013 15.7 0.0 0.02 15.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3738) cwf18 PF08315.12 EDO05353.1 - 1.2e-12 48.6 1.9 1.6e-12 48.3 1.9 1.1 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor PA14 PF07691.12 EDO05354.1 - 3.4e-21 75.6 0.0 6.3e-21 74.7 0.0 1.4 1 0 0 1 1 1 1 PA14 domain fn2 PF00040.19 EDO05354.1 - 0.0031 17.8 1.0 0.0072 16.6 1.0 1.7 1 0 0 1 1 1 1 Fibronectin type II domain GLEYA PF10528.9 EDO05354.1 - 0.019 15.4 0.0 0.06 13.8 0.0 1.9 1 0 0 1 1 1 0 GLEYA domain Fib_alpha PF08702.10 EDO05354.1 - 1.2 9.3 3.3 2 8.6 3.3 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Sortilin-Vps10 PF15902.5 EDO05355.1 - 2.1e-104 349.8 0.0 5.9e-104 348.3 0.0 1.7 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 EDO05355.1 - 9.4e-37 127.0 0.8 1.4e-36 126.4 0.8 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 EDO05355.1 - 0.021 14.7 14.4 3.1 8.2 0.0 7.3 8 0 0 8 8 8 0 BNR/Asp-box repeat BNR_2 PF13088.6 EDO05355.1 - 0.046 13.0 0.0 13 4.9 0.0 3.3 3 0 0 3 3 3 0 BNR repeat-like domain TSP_1 PF00090.19 EDO05356.1 - 0.0022 18.2 0.5 0.2 11.9 0.5 4.8 1 0 0 1 1 1 1 Thrombospondin type 1 domain NADH_dhqG_C PF09326.11 EDO05357.1 - 0.21 12.3 0.1 0.21 12.3 0.1 2.4 2 1 0 2 2 2 0 NADH-ubiquinone oxidoreductase subunit G, C-terminal ISK_Channel PF02060.15 EDO05357.1 - 0.24 11.1 1.1 0.54 10.0 1.1 1.6 1 1 1 2 2 2 0 Slow voltage-gated potassium channel zf-CCCH PF00642.24 EDO05358.1 - 0.005 16.7 0.9 0.005 16.7 0.9 3.8 3 1 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDO05358.1 - 0.11 12.6 13.6 0.1 12.7 1.9 3.3 3 0 0 3 3 3 0 Zinc finger domain zf-CCHC PF00098.23 EDO05359.1 - 1.1e-15 56.9 24.2 0.00018 21.4 0.6 4.3 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_5 PF14787.6 EDO05359.1 - 0.00084 19.0 23.8 0.14 11.9 0.1 4.3 4 0 0 4 4 4 3 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.6 EDO05359.1 - 0.034 13.9 26.3 0.19 11.5 1.5 4.2 4 0 0 4 4 4 0 Zinc knuckle OrfB_IS605 PF01385.19 EDO05359.1 - 6 7.1 5.7 2.7 8.2 0.3 2.1 2 0 0 2 2 2 0 Probable transposase DHHC PF01529.20 EDO05360.1 - 7.7e-25 87.5 14.5 8.4e-25 87.4 11.5 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase COX2_TM PF02790.15 EDO05360.1 - 0.011 15.8 1.6 0.65 10.2 1.6 2.1 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain Methyltransf_11 PF08241.12 EDO05361.1 - 2.4e-13 50.5 0.1 5e-13 49.5 0.1 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDO05361.1 - 1e-11 45.4 0.1 3.4e-11 43.7 0.1 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDO05361.1 - 5.2e-07 29.6 0.0 7.8e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDO05361.1 - 0.0029 17.4 0.0 0.004 17.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDO05361.1 - 0.0054 16.1 0.0 0.009 15.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.12 EDO05361.1 - 0.0062 16.1 0.0 0.0088 15.6 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_12 PF08242.12 EDO05361.1 - 0.018 15.8 0.1 0.045 14.5 0.1 1.7 1 0 0 1 1 1 0 Methyltransferase domain Cys_rich_CWC PF14375.6 EDO05361.1 - 0.043 14.2 0.1 0.08 13.4 0.1 1.4 1 0 0 1 1 1 0 Cysteine-rich CWC Ebp2 PF05890.12 EDO05362.1 - 1.4e-39 136.3 26.9 1.7e-39 136.0 26.9 1.0 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 LMBR1 PF04791.16 EDO05362.1 - 2.4 7.0 4.8 2.7 6.8 4.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Brix PF04427.18 EDO05363.1 - 1.4e-25 90.5 0.0 1.9e-25 90.1 0.0 1.2 1 0 0 1 1 1 1 Brix domain Josephin PF02099.17 EDO05364.1 - 2.8e-18 66.5 0.0 4.2e-18 66.0 0.0 1.2 1 0 0 1 1 1 1 Josephin UBX PF00789.20 EDO05364.1 - 1.7e-06 28.2 0.0 4.5e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 UBX domain EF-hand_6 PF13405.6 EDO05365.1 - 3.4e-05 23.4 0.9 0.0015 18.3 0.2 3.1 2 1 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 EDO05365.1 - 8.2e-05 23.0 0.2 0.0086 16.5 0.1 2.5 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EDO05365.1 - 0.0002 20.6 0.1 0.0081 15.6 0.0 3.4 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.6 EDO05365.1 - 0.0021 17.8 1.2 1.5 8.7 0.0 3.8 5 0 0 5 5 5 1 EF-hand domain pair EF-hand_5 PF13202.6 EDO05365.1 - 0.056 13.0 0.5 0.38 10.3 0.0 2.5 3 0 0 3 3 3 0 EF hand baeRF_family6 PF18848.1 EDO05365.1 - 0.061 13.7 0.0 0.093 13.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 6 E3_binding PF02817.17 EDO05365.1 - 1.2 9.6 3.7 8.1 6.9 0.1 3.4 4 0 0 4 4 4 0 e3 binding domain Lipoprotein_20 PF13942.6 EDO05366.1 - 0.0033 17.4 1.6 0.0037 17.2 0.5 1.6 2 0 0 2 2 2 1 YfhG lipoprotein DUF948 PF06103.11 EDO05366.1 - 0.023 14.9 3.2 38 4.6 0.1 4.2 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF29 PF01724.16 EDO05366.1 - 0.056 13.7 0.8 0.94 9.7 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function DUF29 TK PF00265.18 EDO05366.1 - 0.11 12.3 1.9 0.5 10.2 0.1 2.4 2 0 0 2 2 2 0 Thymidine kinase Sec34 PF04136.15 EDO05366.1 - 0.12 12.2 1.9 2.4 8.0 0.1 3.3 3 1 0 3 3 3 0 Sec34-like family YabA PF06156.13 EDO05366.1 - 0.76 10.4 2.9 5.7 7.6 0.0 3.1 4 0 0 4 4 4 0 Initiation control protein YabA DUF1759 PF03564.15 EDO05366.1 - 9.5 6.1 10.3 2 8.3 0.4 3.6 2 2 2 4 4 4 0 Protein of unknown function (DUF1759) Ribosomal_L3 PF00297.22 EDO05367.1 - 4.7e-162 539.2 2.3 5.3e-162 539.0 2.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 ENTH PF01417.20 EDO05369.1 - 7.1e-22 77.8 0.0 1.2e-21 77.0 0.0 1.4 1 0 0 1 1 1 1 ENTH domain ocr PF08684.10 EDO05370.1 - 0.036 14.5 1.9 0.071 13.6 0.2 2.1 2 0 0 2 2 2 0 DNA mimic ocr EMG1 PF03587.14 EDO05371.1 - 1.3e-46 158.8 0.0 1.5e-46 158.5 0.0 1.1 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase ImcF-related_N PF14331.6 EDO05372.1 - 0.12 11.7 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 ImcF-related N-terminal domain TFIIS_M PF07500.14 EDO05373.1 - 9.7e-24 84.0 1.2 9.7e-24 84.0 1.2 2.2 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 EDO05373.1 - 3.6e-19 68.3 3.4 6.7e-19 67.5 3.4 1.5 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 EDO05373.1 - 6.4e-10 38.9 0.5 1.8e-09 37.4 0.5 1.8 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Elf1 PF05129.13 EDO05373.1 - 0.022 14.8 1.0 0.054 13.5 1.0 1.7 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like RNA_POL_M_15KD PF02150.16 EDO05373.1 - 0.76 9.7 4.5 0.97 9.4 0.1 2.4 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit Cytochrome_C554 PF13435.6 EDO05373.1 - 8.6 7.4 7.6 1.3 10.0 1.9 2.4 2 1 0 2 2 2 0 Cytochrome c554 and c-prime Tho2 PF11262.8 EDO05374.1 - 0.089 12.0 0.0 0.21 10.7 0.0 1.5 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 WD40 PF00400.32 EDO05375.1 - 0.056 14.3 20.9 0.8 10.7 0.0 7.1 8 1 0 8 8 8 0 WD domain, G-beta repeat HA2 PF04408.23 EDO05376.1 - 5.2e-26 91.0 0.1 2.1e-25 89.1 0.1 2.1 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EDO05376.1 - 2e-22 79.3 0.0 4.1e-22 78.3 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EDO05376.1 - 2.1e-10 40.9 0.0 8.9e-10 38.9 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain S1 PF00575.23 EDO05376.1 - 1.8e-06 28.2 1.1 4.8e-06 26.8 0.7 2.0 2 0 0 2 2 2 1 S1 RNA binding domain DEAD PF00270.29 EDO05376.1 - 3e-05 23.9 0.1 7.1e-05 22.6 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDO05376.1 - 5.1e-05 23.6 0.1 0.00024 21.4 0.1 2.2 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 EDO05376.1 - 0.012 14.7 0.0 0.023 13.7 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_29 PF13555.6 EDO05376.1 - 0.088 12.6 0.0 0.41 10.4 0.0 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EDO05376.1 - 0.13 12.8 0.1 0.77 10.3 0.1 2.3 1 1 0 1 1 1 0 ABC transporter Spt4 PF06093.13 EDO05377.1 - 3e-17 62.5 0.2 1e-16 60.8 0.2 1.7 1 1 0 1 1 1 1 Spt4/RpoE2 zinc finger GLE1 PF07817.13 EDO05378.1 - 3.6e-18 65.7 0.1 8.2e-18 64.5 0.1 1.5 1 0 0 1 1 1 1 GLE1-like protein DUF4455 PF14643.6 EDO05378.1 - 0.016 13.9 3.7 0.58 8.7 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4455) DUF3510 PF12022.8 EDO05378.1 - 0.021 15.2 0.8 0.021 15.2 0.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3510) LMBR1 PF04791.16 EDO05378.1 - 0.023 13.6 2.2 0.038 12.9 2.2 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF713 PF05218.14 EDO05378.1 - 0.054 13.2 0.6 0.054 13.2 0.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF713) Mis14 PF08641.12 EDO05378.1 - 0.42 10.9 12.7 6.3 7.1 1.7 2.9 3 0 0 3 3 3 0 Kinetochore protein Mis14 like Mitofilin PF09731.9 EDO05378.1 - 0.42 9.4 12.1 0.075 11.9 5.2 2.2 2 0 0 2 2 2 0 Mitochondrial inner membrane protein Tho2 PF11262.8 EDO05378.1 - 1 8.5 6.8 0.32 10.2 1.0 2.1 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 Fib_alpha PF08702.10 EDO05378.1 - 1.6 8.9 13.8 0.12 12.5 3.9 2.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Cdh1_DBD_1 PF18196.1 EDO05378.1 - 2.2 8.6 10.8 6.9 7.0 1.0 2.3 2 0 0 2 2 2 0 Chromodomain helicase DNA-binding domain 1 YlqD PF11068.8 EDO05378.1 - 3.6 8.0 5.9 1.5 9.2 0.5 2.2 2 0 0 2 2 2 0 YlqD protein DUF4298 PF14131.6 EDO05378.1 - 4.3 7.4 8.7 0.35 10.9 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4298) IMD PF08397.11 EDO05378.1 - 4.8 6.5 8.2 6.8 6.0 0.9 2.3 2 0 0 2 2 2 0 IRSp53/MIM homology domain PI3_PI4_kinase PF00454.27 EDO05379.1 - 4e-32 112.0 0.1 1e-23 84.4 0.0 2.3 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EDO05379.1 - 2.4e-10 40.1 0.0 4.6e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 EDO05379.1 - 0.066 12.5 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) QueF PF14489.6 EDO05379.1 - 0.083 13.1 0.0 9.8 6.4 0.0 2.7 2 0 0 2 2 2 0 QueF-like protein Thiolase_N PF00108.23 EDO05380.1 - 1.2e-34 119.9 0.0 1.5e-34 119.6 0.0 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EDO05380.1 - 2.5e-19 69.1 0.0 4.7e-19 68.2 0.0 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 EDO05380.1 - 0.0071 16.2 0.0 3 7.8 0.0 2.7 2 0 0 2 2 2 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III MSA-2c PF12238.8 EDO05381.1 - 2e-91 305.8 5.2 2.9e-91 305.3 5.2 1.2 1 0 0 1 1 1 1 Merozoite surface antigen 2c Velvet PF11754.8 EDO05381.1 - 0.0068 16.4 0.6 0.011 15.7 0.6 1.3 1 0 0 1 1 1 1 Velvet factor DUF2004 PF09406.10 EDO05381.1 - 1.7 9.0 6.7 1.4 9.3 0.5 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF2004) MSA-2c PF12238.8 EDO05382.1 - 3.4e-62 210.2 32.6 2.1e-54 184.8 11.4 2.2 1 1 1 2 2 2 2 Merozoite surface antigen 2c SRP-alpha_N PF04086.13 EDO05382.1 - 0.92 9.4 7.3 1.6 8.6 7.3 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF2004 PF09406.10 EDO05382.1 - 1.7 9.0 4.9 1.7 9.0 0.4 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF2004) DUF2486 PF10667.9 EDO05382.1 - 4.7 7.4 15.1 7.5 6.7 15.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2486) MSA-2c PF12238.8 EDO05383.1 - 5.6e-45 154.0 35.1 3.3e-42 144.9 35.1 2.2 1 1 0 1 1 1 1 Merozoite surface antigen 2c Peptidase_C65 PF10275.9 EDO05383.1 - 0.049 13.1 2.0 0.07 12.6 2.0 1.3 1 0 0 1 1 1 0 Peptidase C65 Otubain YfbU PF03887.14 EDO05383.1 - 0.14 12.2 1.5 0.28 11.2 0.1 2.0 1 1 0 2 2 2 0 YfbU domain SOG2 PF10428.9 EDO05383.1 - 4.5 6.3 10.4 7.4 5.7 10.4 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein MSA-2c PF12238.8 EDO05384.1 - 5.2e-64 216.2 15.9 7.6e-63 212.4 15.9 2.6 1 1 0 1 1 1 1 Merozoite surface antigen 2c LUD_dom PF02589.15 EDO05384.1 - 0.019 14.7 0.0 0.03 14.0 0.0 1.3 1 1 0 1 1 1 0 LUD domain Lipoprotein_19 PF13617.6 EDO05386.1 - 0.098 12.5 0.3 0.3 10.9 0.3 1.8 1 0 0 1 1 1 0 YnbE-like lipoprotein Bax1-I PF01027.20 EDO05387.1 - 2.2e-25 89.7 32.1 2.5e-25 89.5 32.1 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 OST3_OST6 PF04756.13 EDO05387.1 - 5.5 6.2 15.3 0.11 11.8 2.9 2.4 2 1 0 2 2 2 0 OST3 / OST6 family, transporter family DUF1003 PF06210.11 EDO05387.1 - 5.7 7.1 9.9 6.7 6.9 1.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) DUF2070 PF09843.9 EDO05387.1 - 8.6 4.5 26.0 11 4.2 26.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) MSA-2c PF12238.8 EDO05388.1 - 8.2e-107 356.1 1.3 1.2e-106 355.6 1.3 1.2 1 0 0 1 1 1 1 Merozoite surface antigen 2c PseudoU_synth_1 PF01416.20 EDO05388.1 - 0.0033 17.9 0.0 0.0066 16.9 0.0 1.7 1 1 0 1 1 1 1 tRNA pseudouridine synthase SIR2 PF02146.17 EDO05389.1 - 1.1e-26 93.9 0.0 1.6e-26 93.3 0.0 1.3 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 EDO05389.1 - 0.063 13.0 0.0 7 6.4 0.0 2.5 3 0 0 3 3 3 0 Thiamine pyrophosphate enzyme, central domain zf-Nse PF11789.8 EDO05390.1 - 4.6e-12 45.6 0.1 8.2e-12 44.8 0.1 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 EDO05390.1 - 0.005 16.8 0.8 0.012 15.7 0.4 1.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 EDO05390.1 - 0.03 14.6 1.7 0.12 12.8 0.2 2.4 3 1 0 3 3 3 0 Ring finger domain GTP_EFTU PF00009.27 EDO05391.1 - 1.9e-63 213.5 0.0 2.8e-63 213.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EDO05391.1 - 4.5e-29 100.7 0.0 1.6e-28 98.9 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 EDO05391.1 - 6.7e-22 77.3 0.0 1.4e-21 76.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 EDO05391.1 - 7.8e-15 54.7 0.0 1.5e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EDO05391.1 - 5.1e-13 49.2 0.1 1.3e-12 47.9 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDO05391.1 - 0.0018 18.3 0.1 0.0036 17.4 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RF3_C PF16658.5 EDO05391.1 - 0.062 13.1 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain cwf21 PF08312.12 EDO05392.1 - 3.4e-05 23.9 4.4 9.4e-05 22.5 4.4 1.8 1 0 0 1 1 1 1 cwf21 domain Apolipoprotein PF01442.18 EDO05394.1 - 1.2e-05 25.3 23.0 0.0055 16.6 6.0 4.2 3 1 1 4 4 4 3 Apolipoprotein A1/A4/E domain ANAPC4 PF12896.7 EDO05394.1 - 0.17 11.4 9.9 0.99 8.9 0.2 4.0 3 2 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 4 REF PF05755.12 EDO05394.1 - 0.19 11.5 9.4 0.049 13.4 2.0 3.0 1 1 3 4 4 4 0 Rubber elongation factor protein (REF) Snapin_Pallidin PF14712.6 EDO05394.1 - 6.5 7.2 21.6 10 6.6 0.3 5.3 4 1 2 6 6 6 0 Snapin/Pallidin Cep57_MT_bd PF06657.13 EDO05395.1 - 0.068 13.6 0.1 0.16 12.5 0.1 1.6 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 HhH-GPD PF00730.25 EDO05396.1 - 2.5e-25 89.0 0.0 3.1e-25 88.7 0.0 1.1 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EDO05396.1 - 5.7e-08 32.2 0.0 1.3e-07 31.1 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 EDO05396.1 - 0.019 15.6 0.1 0.74 10.5 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix domain Cdd1 PF11731.8 EDO05396.1 - 0.029 14.6 0.0 0.093 13.0 0.0 1.8 1 1 0 1 1 1 0 Pathogenicity locus UTP15_C PF09384.10 EDO05396.1 - 0.031 14.0 0.0 0.049 13.3 0.0 1.3 1 0 0 1 1 1 0 UTP15 C terminal Glycos_trans_3N PF02885.17 EDO05396.1 - 0.068 13.0 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase family, helical bundle domain Rota_VP4_MID PF17477.2 EDO05397.1 - 0.057 12.8 0.1 0.36 10.2 0.0 1.9 2 0 0 2 2 2 0 Rotavirus VP4 membrane interaction domain Ribosomal_L19e PF01280.20 EDO05398.1 - 6.4e-59 198.1 6.3 6.4e-59 198.1 6.3 1.4 2 0 0 2 2 2 1 Ribosomal protein L19e GAT PF03127.14 EDO05398.1 - 0.042 14.1 0.1 0.93 9.8 0.0 2.1 1 1 1 2 2 2 0 GAT domain Fe_hyd_lg_C PF02906.14 EDO05399.1 - 1.7e-45 155.6 0.0 8.5e-45 153.3 0.0 2.1 1 1 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain ABC_tran PF00005.27 EDO05400.1 - 1.8e-29 103.0 0.0 8.9e-15 55.4 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EDO05400.1 - 9.1e-12 45.2 29.3 2.5e-11 43.7 8.4 3.6 3 0 0 3 3 3 2 ABC transporter transmembrane region RsgA_GTPase PF03193.16 EDO05400.1 - 3.2e-08 33.7 0.4 0.00052 19.9 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EDO05400.1 - 8.5e-08 31.8 0.5 0.014 15.1 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EDO05400.1 - 2.4e-07 31.5 0.9 0.025 15.1 0.1 2.2 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 EDO05400.1 - 7.3e-07 29.3 0.9 0.0089 16.1 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_30 PF13604.6 EDO05400.1 - 2.1e-05 24.3 1.4 0.61 9.8 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_21 PF13304.6 EDO05400.1 - 8.9e-05 22.4 1.7 0.08 12.7 0.1 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDO05400.1 - 0.00013 21.5 0.3 0.86 9.0 0.0 3.4 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain FtsK_SpoIIIE PF01580.18 EDO05400.1 - 0.00013 21.4 0.0 0.064 12.6 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_16 PF13191.6 EDO05400.1 - 0.00021 21.7 1.5 0.15 12.4 0.1 2.5 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 EDO05400.1 - 0.00031 20.7 1.7 0.42 10.5 0.1 2.7 2 0 0 2 2 2 2 NACHT domain Dynamin_N PF00350.23 EDO05400.1 - 0.00036 20.6 1.3 0.89 9.6 0.0 2.3 2 0 0 2 2 2 2 Dynamin family AAA PF00004.29 EDO05400.1 - 0.00037 20.9 0.5 0.018 15.4 0.1 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDO05400.1 - 0.00063 20.0 0.3 1.8 8.8 0.0 2.9 2 0 0 2 2 2 2 AAA domain T2SSE PF00437.20 EDO05400.1 - 0.0024 17.0 1.3 0.47 9.5 0.0 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein Zeta_toxin PF06414.12 EDO05400.1 - 0.0029 16.9 0.7 2.2 7.5 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin cobW PF02492.19 EDO05400.1 - 0.0033 17.0 4.2 0.084 12.4 0.5 2.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 EDO05400.1 - 0.0048 16.1 0.3 3.1 6.9 0.0 2.3 2 0 0 2 2 2 2 NB-ARC domain DUF87 PF01935.17 EDO05400.1 - 0.0072 16.4 5.4 0.013 15.6 0.9 2.9 3 0 0 3 3 3 1 Helicase HerA, central domain AAA_18 PF13238.6 EDO05400.1 - 0.011 16.3 0.2 7.5 7.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EDO05400.1 - 0.015 14.9 0.4 4.5 6.8 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EDO05400.1 - 0.031 14.4 2.2 3.1 8.0 0.1 2.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EDO05400.1 - 0.032 14.6 0.1 9.2 6.7 0.0 2.8 2 0 0 2 2 2 0 RNA helicase ATPase_2 PF01637.18 EDO05400.1 - 0.037 13.9 0.0 1.2 9.0 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 EDO05400.1 - 0.039 13.5 0.1 5.5 6.5 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region SbcCD_C PF13558.6 EDO05400.1 - 0.062 13.6 0.0 0.17 12.2 0.0 1.7 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit FeoB_N PF02421.18 EDO05400.1 - 0.068 12.7 0.4 3.9 7.0 0.1 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_5 PF07728.14 EDO05400.1 - 0.077 13.0 2.7 2.9 7.9 0.2 2.7 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 EDO05400.1 - 0.082 13.2 0.1 0.082 13.2 0.1 2.8 3 0 0 3 3 3 0 AAA domain ATP_bind_1 PF03029.17 EDO05400.1 - 0.094 12.5 0.2 21 4.8 0.0 2.7 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 EDO05400.1 - 0.11 12.3 0.1 7 6.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain MobB PF03205.14 EDO05400.1 - 0.11 12.4 0.5 13 5.7 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B NTPase_1 PF03266.15 EDO05400.1 - 0.12 12.3 1.1 14 5.5 0.1 2.3 2 0 0 2 2 2 0 NTPase Mg_chelatase PF01078.21 EDO05400.1 - 0.12 11.7 0.2 3.9 6.8 0.1 2.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EDO05400.1 - 0.14 12.3 2.4 8.6 6.6 0.1 2.4 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 EDO05400.1 - 0.15 11.0 0.5 4.3 6.2 0.2 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Ploopntkinase3 PF18751.1 EDO05400.1 - 0.18 11.7 0.3 3.5 7.5 0.1 2.3 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 TsaE PF02367.17 EDO05400.1 - 0.2 11.7 0.2 7.9 6.5 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_15 PF13175.6 EDO05400.1 - 0.24 11.0 1.1 7.5 6.1 0.3 2.1 2 0 0 2 2 2 0 AAA ATPase domain DLIC PF05783.11 EDO05400.1 - 0.27 10.0 0.2 18 4.0 0.1 2.3 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) IstB_IS21 PF01695.17 EDO05400.1 - 0.29 10.8 1.1 19 4.9 0.1 2.6 2 0 0 2 2 2 0 IstB-like ATP binding protein Roc PF08477.13 EDO05400.1 - 0.36 11.1 0.9 12 6.2 0.1 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_17 PF13207.6 EDO05400.1 - 0.5 10.8 1.3 9.8 6.6 0.1 2.4 2 0 0 2 2 2 0 AAA domain DUF4195 PF13836.6 EDO05401.1 - 0.0054 16.9 0.5 0.0072 16.5 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4195) Beta-Casp PF10996.8 EDO05406.1 - 5.1e-22 78.3 0.0 2.1e-21 76.3 0.0 2.1 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 EDO05406.1 - 2.7e-15 56.0 0.1 5.4e-15 55.1 0.1 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_6 PF16661.5 EDO05406.1 - 5e-15 55.4 0.0 1.9e-14 53.6 0.0 1.9 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 EDO05406.1 - 1e-10 42.0 0.1 1.4e-08 35.0 0.1 3.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EDO05406.1 - 5.9e-06 25.9 0.5 0.0082 15.7 0.0 3.3 4 0 0 4 4 4 2 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EDO05406.1 - 0.051 13.5 0.0 0.58 10.0 0.0 2.6 1 1 0 1 1 1 0 Beta-lactamase superfamily domain FtsJ PF01728.19 EDO05407.1 - 9.7e-34 117.0 0.4 2e-25 89.9 0.0 2.7 3 0 0 3 3 3 2 FtsJ-like methyltransferase CARD PF00619.21 EDO05407.1 - 0.016 15.2 0.1 5.5 7.1 0.0 3.4 3 0 0 3 3 3 0 Caspase recruitment domain Methyltrans_Mon PF14314.6 EDO05407.1 - 0.049 11.7 0.2 0.087 10.8 0.2 1.3 1 0 0 1 1 1 0 Virus-capping methyltransferase HTH_23 PF13384.6 EDO05408.1 - 0.038 13.8 0.0 0.089 12.6 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain HTH_10 PF04967.12 EDO05408.1 - 0.066 13.0 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 HTH DNA binding domain DUF4366 PF14283.6 EDO05409.1 - 0.079 13.0 3.5 2.8 8.0 3.5 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) CAP_C PF08603.11 EDO05410.1 - 7.7e-38 129.6 7.2 8.8e-38 129.4 7.2 1.0 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 EDO05410.1 - 0.44 10.3 10.2 1.1 9.0 9.8 1.8 1 1 0 1 1 1 0 Tubulin binding cofactor C SAP PF02037.27 EDO05411.1 - 1.5e-06 27.8 3.9 3.3e-06 26.7 3.9 1.6 1 0 0 1 1 1 1 SAP domain Telomere_Sde2_2 PF13297.6 EDO05411.1 - 0.093 12.4 0.3 0.093 12.4 0.3 2.3 2 0 0 2 2 2 0 Telomere stability C-terminal PhoD PF09423.10 EDO05412.1 - 2.8e-17 62.8 0.2 8.5e-08 31.6 0.0 3.6 4 0 0 4 4 4 3 PhoD-like phosphatase Lysis_col PF02402.16 EDO05412.1 - 0.096 12.4 0.2 0.2 11.4 0.2 1.5 1 0 0 1 1 1 0 Lysis protein Ank_4 PF13637.6 EDO05413.1 - 3.9e-39 132.5 4.3 1.2e-12 48.0 0.1 5.0 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDO05413.1 - 1.6e-32 111.9 4.3 7e-12 45.8 0.0 3.2 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) RNA_GG_bind PF10258.9 EDO05413.1 - 6.5e-25 87.0 0.0 1.4e-24 86.0 0.0 1.6 1 0 0 1 1 1 1 PHAX RNA-binding domain Ank_5 PF13857.6 EDO05413.1 - 1.2e-22 79.6 2.1 3e-08 33.8 0.1 4.8 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 EDO05413.1 - 2.5e-20 72.0 1.4 0.00013 22.3 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EDO05413.1 - 4.9e-20 69.5 0.4 0.00061 20.0 0.0 5.7 5 0 0 5 5 5 4 Ankyrin repeat Methyltransf_16 PF10294.9 EDO05414.1 - 9.9e-07 28.7 0.0 0.00084 19.1 0.0 2.3 2 0 0 2 2 2 2 Lysine methyltransferase MTS PF05175.14 EDO05414.1 - 0.0071 15.9 0.0 0.013 15.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Cpn60_TCP1 PF00118.24 EDO05416.1 - 1.9e-155 518.2 6.0 2.2e-155 518.1 6.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family GlcNAc-1_reg PF18440.1 EDO05416.1 - 0.016 15.4 0.1 4.5 7.6 0.0 2.7 2 0 0 2 2 2 0 Putative GlcNAc-1 phosphotransferase regulatory domain CDC50 PF03381.15 EDO05417.1 - 8.2e-25 87.9 2.1 1.5e-24 87.0 1.8 1.5 1 1 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family CD20 PF04103.15 EDO05417.1 - 0.078 13.1 0.7 8.1 6.5 0.0 2.3 2 0 0 2 2 2 0 CD20-like family Caveolin PF01146.17 EDO05417.1 - 0.47 10.4 0.0 0.47 10.4 0.0 1.8 2 0 0 2 2 2 0 Caveolin RNA_pol_Rpb1_5 PF04998.17 EDO05418.1 - 3.7e-100 334.8 0.2 6.3e-100 334.0 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 EDO05418.1 - 3.9e-95 318.8 0.8 7.1e-95 317.9 0.2 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 EDO05418.1 - 1.5e-72 243.2 0.0 2.9e-72 242.3 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 EDO05418.1 - 6e-49 166.5 0.1 1.3e-48 165.4 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 EDO05418.1 - 5.2e-46 156.4 0.0 1.3e-45 155.1 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.12 EDO05418.1 - 1.4e-43 148.1 3.7 3e-43 147.1 3.7 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 EDO05418.1 - 2.2e-37 127.3 0.0 5.4e-37 126.0 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 EDO05418.1 - 1.3e-17 63.1 223.0 0.0063 16.8 12.5 15.0 9 1 9 19 19 19 15 RNA polymerase Rpb1 C-terminal repeat Band_7 PF01145.25 EDO05419.1 - 4.7e-27 95.1 0.2 1e-26 94.0 0.2 1.5 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_C PF16200.5 EDO05419.1 - 2.3e-23 82.0 0.4 5.2e-23 80.9 0.4 1.6 1 0 0 1 1 1 1 C-terminal region of band_7 Band_7_1 PF13421.6 EDO05419.1 - 0.011 15.4 0.4 0.031 14.0 0.1 1.8 2 0 0 2 2 2 0 SPFH domain-Band 7 family L_biotic_typeA PF04604.13 EDO05421.1 - 0.075 12.9 0.0 0.19 11.6 0.0 1.7 1 0 0 1 1 1 0 Type-A lantibiotic Terminase_3C PF17288.2 EDO05422.1 - 0.011 16.1 0.5 0.018 15.4 0.5 1.3 1 0 0 1 1 1 0 Terminase RNAseH like domain Ribosomal_L21p PF00829.21 EDO05423.1 - 4.1e-24 84.8 0.5 6.6e-24 84.1 0.1 1.5 2 0 0 2 2 2 1 Ribosomal prokaryotic L21 protein GTP_EFTU PF00009.27 EDO05424.1 - 4.9e-28 98.0 3.2 3.2e-26 92.1 3.2 2.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDO05424.1 - 4.5e-08 33.2 0.0 9.8e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 EDO05424.1 - 7.5e-06 25.9 0.0 2.6e-05 24.2 0.0 1.9 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain Ras PF00071.22 EDO05424.1 - 2e-05 24.2 0.0 4e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Ras family IF-2 PF11987.8 EDO05424.1 - 0.0002 21.4 0.0 0.037 14.1 0.0 2.8 1 1 0 1 1 1 1 Translation-initiation factor 2 Arf PF00025.21 EDO05424.1 - 0.0012 18.4 0.0 0.0023 17.4 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.9 EDO05424.1 - 0.0059 16.4 0.1 0.016 14.9 0.1 1.8 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 EDO05424.1 - 0.011 15.3 0.3 0.09 12.3 0.3 2.4 1 1 0 1 1 1 0 Ferrous iron transport protein B Roc PF08477.13 EDO05424.1 - 0.046 13.9 0.0 0.092 13.0 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase DEAD PF00270.29 EDO05425.1 - 2e-43 148.2 0.0 4.3e-43 147.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO05425.1 - 3.7e-26 91.6 0.2 6.8e-25 87.6 0.0 2.9 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 EDO05425.1 - 1.7e-10 41.0 3.4 1.7e-10 41.0 3.4 3.0 3 0 0 3 3 3 1 DBP10CT (NUC160) domain AAA_22 PF13401.6 EDO05425.1 - 0.018 15.3 0.1 0.17 12.2 0.1 2.5 1 1 0 1 1 1 0 AAA domain HSP70 PF00012.20 EDO05426.1 - 8.7e-30 103.5 0.7 1.8e-27 95.8 0.0 2.5 2 1 0 2 2 2 1 Hsp70 protein TPR_1 PF00515.28 EDO05426.1 - 8.3e-07 28.6 11.8 0.017 14.9 0.1 4.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 EDO05426.1 - 8.9e-06 25.3 0.4 0.18 11.5 0.1 2.8 2 0 0 2 2 2 2 TPR repeat TPR_17 PF13431.6 EDO05426.1 - 6.7e-05 23.0 0.2 0.015 15.7 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDO05426.1 - 9e-05 22.3 8.6 0.27 11.4 0.1 4.6 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 EDO05426.1 - 0.00064 20.2 0.1 0.00064 20.2 0.1 3.4 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDO05426.1 - 0.026 15.3 3.8 10 7.2 0.0 3.8 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 EDO05426.1 - 0.071 13.3 0.1 0.22 11.7 0.1 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF627 PF04781.12 EDO05426.1 - 0.089 12.8 0.4 1.7 8.7 0.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF627) TPR_12 PF13424.6 EDO05426.1 - 0.42 10.9 0.0 0.42 10.9 0.0 2.7 3 1 0 3 3 3 0 Tetratricopeptide repeat HSA PF07529.13 EDO05426.1 - 7.3 7.0 12.2 0.38 11.1 1.1 3.3 3 0 0 3 3 3 0 HSA Flavokinase PF01687.17 EDO05427.1 - 5.9e-22 78.1 0.0 1.4e-21 76.9 0.0 1.6 1 0 0 1 1 1 1 Riboflavin kinase MMR_HSR1_Xtn PF16897.5 EDO05428.1 - 3e-40 136.5 0.9 6.8e-40 135.4 0.9 1.6 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 EDO05428.1 - 2.9e-20 72.5 0.0 5.3e-20 71.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 EDO05428.1 - 4e-14 52.4 0.0 1e-13 51.1 0.0 1.7 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EDO05428.1 - 1.1e-11 44.6 0.0 1.6e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EDO05428.1 - 0.00064 19.8 0.1 0.23 11.5 0.0 2.4 1 1 1 2 2 2 2 Dynamin family AAA_28 PF13521.6 EDO05428.1 - 0.0055 17.0 0.0 0.01 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain Roc PF08477.13 EDO05428.1 - 0.011 16.0 0.1 0.76 10.0 0.0 2.5 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 EDO05428.1 - 0.015 15.9 0.2 0.054 14.0 0.0 2.1 2 1 0 2 2 2 0 AAA domain MeaB PF03308.16 EDO05428.1 - 0.026 13.5 0.1 0.34 9.8 0.0 2.5 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AIG1 PF04548.16 EDO05428.1 - 0.031 13.6 0.0 0.053 12.8 0.0 1.4 1 0 0 1 1 1 0 AIG1 family Mg_chelatase PF01078.21 EDO05428.1 - 0.033 13.6 0.0 0.078 12.4 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA PF00004.29 EDO05428.1 - 0.04 14.3 0.1 5.2 7.5 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EDO05428.1 - 0.053 13.4 0.4 0.51 10.2 0.0 2.4 3 0 0 3 3 3 0 RsgA GTPase Ribosomal_S13_N PF08069.12 EDO05429.1 - 1e-27 95.9 0.8 1.8e-27 95.2 0.8 1.4 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 EDO05429.1 - 8.2e-13 48.4 0.4 1.3e-12 47.7 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein S15 HMG_box_2 PF09011.10 EDO05430.1 - 0.00026 21.5 0.0 0.00043 20.8 0.0 1.3 1 0 0 1 1 1 1 HMG-box domain CBFD_NFYB_HMF PF00808.23 EDO05430.1 - 0.0018 18.5 0.0 0.004 17.4 0.0 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Myosin_head PF00063.21 EDO05431.1 - 1.7e-184 614.8 1.7 2e-184 614.6 1.7 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) CbiA PF01656.23 EDO05431.1 - 0.058 13.5 0.0 0.37 10.9 0.0 2.2 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_22 PF13401.6 EDO05431.1 - 0.12 12.6 0.0 0.93 9.8 0.0 2.5 3 0 0 3 3 3 0 AAA domain NDUFB10 PF10249.9 EDO05432.1 - 0.1 13.1 1.9 0.38 11.3 0.0 2.4 2 1 1 3 3 3 0 NADH-ubiquinone oxidoreductase subunit 10 Exo_endo_phos PF03372.23 EDO05434.1 - 4.8e-17 62.3 0.0 1.7e-16 60.5 0.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RRM_1 PF00076.22 EDO05435.1 - 4.4e-56 186.6 0.0 1.3e-19 69.7 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDO05435.1 - 3.7e-12 45.9 0.1 0.0031 17.1 0.0 3.2 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WW PF00397.26 EDO05435.1 - 4.4e-10 39.5 3.0 1.1e-09 38.1 3.0 1.7 1 0 0 1 1 1 1 WW domain RRM_7 PF16367.5 EDO05435.1 - 1.7e-08 34.5 0.1 0.23 11.6 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif RNA_bind PF08675.11 EDO05435.1 - 6.9e-08 32.4 0.0 0.0012 18.8 0.0 3.5 3 2 0 3 3 3 2 RNA binding domain RRM_occluded PF16842.5 EDO05435.1 - 8e-06 25.6 0.0 3.4 7.6 0.0 3.3 3 0 0 3 3 3 3 Occluded RNA-recognition motif PHM7_cyt PF14703.6 EDO05435.1 - 6.9e-05 23.2 0.2 0.94 9.7 0.0 3.7 3 1 1 4 4 4 2 Cytosolic domain of 10TM putative phosphate transporter Nup35_RRM PF05172.13 EDO05435.1 - 0.0027 17.7 0.0 0.071 13.1 0.0 2.7 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif BRAP2 PF07576.12 EDO05435.1 - 0.0041 17.3 0.1 2.4 8.4 0.0 2.4 2 0 0 2 2 2 2 BRCA1-associated protein 2 Limkain-b1 PF11608.8 EDO05435.1 - 0.0054 16.8 0.1 0.68 10.0 0.0 2.4 2 0 0 2 2 2 1 Limkain b1 Glyco_hyd_101C PF17451.2 EDO05435.1 - 0.11 12.7 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase 101 beta sandwich domain RNB PF00773.19 EDO05436.1 - 5.4e-98 328.3 0.0 7.8e-98 327.8 0.0 1.2 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 EDO05436.1 - 2.3e-16 59.6 0.0 4.4e-16 58.7 0.0 1.5 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 EDO05436.1 - 1.4e-06 28.4 0.4 5.1e-06 26.6 0.1 2.2 2 0 0 2 2 2 1 Cold shock domain Rrp44_CSD1 PF17216.3 EDO05436.1 - 0.032 13.9 0.0 0.2 11.4 0.0 2.3 2 0 0 2 2 2 0 Rrp44-like cold shock domain PEPCK_ATP PF01293.20 EDO05437.1 - 1.2e-209 696.7 0.0 1.5e-209 696.5 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.6 EDO05437.1 - 0.16 12.1 0.0 0.34 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EDO05437.1 - 0.22 11.3 1.3 0.67 9.8 0.4 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain AP2 PF00847.20 EDO05438.1 - 6.9e-06 26.2 0.2 0.19 12.0 0.0 3.3 3 0 0 3 3 3 2 AP2 domain DUF192 PF02643.15 EDO05439.1 - 0.002 18.3 0.0 0.0034 17.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized ACR, COG1430 UDPGP PF01704.18 EDO05440.1 - 1.1e-22 80.3 0.0 1.4e-22 80.0 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 EDO05440.1 - 0.0012 19.2 0.0 0.0022 18.4 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain Kelch_1 PF01344.25 EDO05441.1 - 3.1e-48 161.1 5.4 1.7e-12 46.7 0.6 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 EDO05441.1 - 8.2e-32 108.4 0.4 1.5e-06 28.2 0.0 6.3 4 1 2 6 6 6 6 Kelch motif Kelch_4 PF13418.6 EDO05441.1 - 1.7e-20 72.7 0.8 0.0024 17.8 0.0 5.7 4 2 2 6 6 6 4 Galactose oxidase, central domain BTB_2 PF02214.22 EDO05441.1 - 4.3e-18 65.4 0.0 1.4e-17 63.8 0.0 1.9 1 0 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.6 EDO05441.1 - 1.3e-16 60.4 3.7 0.0013 19.0 0.0 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 EDO05441.1 - 2.1e-09 37.1 0.1 5 7.2 0.0 6.6 7 0 0 7 7 7 2 Kelch motif Kelch_2 PF07646.15 EDO05441.1 - 1.7e-08 34.1 4.2 0.79 9.8 0.1 6.6 7 0 0 7 7 7 3 Kelch motif DUF501 PF04417.12 EDO05441.1 - 0.00093 19.0 0.9 0.00093 19.0 0.9 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF501) Atg14 PF10186.9 EDO05441.1 - 0.14 11.2 4.6 0.2 10.7 4.6 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Exonuc_VII_L PF02601.15 EDO05441.1 - 2 7.9 8.8 2.9 7.4 8.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Chorein_N PF12624.7 EDO05442.1 - 2.6e-18 66.2 0.2 6.5e-18 64.9 0.2 1.7 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 VPS13_C PF16909.5 EDO05442.1 - 8.6e-10 38.7 0.0 2.1e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal VPS13 PF16908.5 EDO05442.1 - 2.7e-07 30.6 0.0 2.4e-06 27.5 0.0 2.6 2 0 0 2 2 2 1 Vacuolar sorting-associated protein 13, N-terminal WD40 PF00400.32 EDO05443.1 - 9.8e-22 76.9 5.0 0.005 17.7 0.0 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat PRP4 PF08799.11 EDO05443.1 - 1.1e-12 47.2 1.6 1.1e-12 47.2 1.6 1.9 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like ANAPC4_WD40 PF12894.7 EDO05443.1 - 3e-12 46.7 0.0 0.013 15.8 0.0 5.7 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDO05443.1 - 0.00035 20.5 0.1 0.68 9.8 0.0 2.9 2 1 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.6 EDO05443.1 - 0.0077 15.8 0.0 0.015 14.9 0.0 1.4 1 1 0 1 1 1 1 PQQ-like domain Ge1_WD40 PF16529.5 EDO05443.1 - 0.021 13.8 0.5 3 6.7 0.0 3.6 3 1 2 5 5 5 0 WD40 region of Ge1, enhancer of mRNA-decapping protein HCBP_related PF06594.11 EDO05443.1 - 0.11 12.5 0.0 0.28 11.2 0.0 1.8 1 0 0 1 1 1 0 Haemolysin-type calcium binding protein related domain MFS_1 PF07690.16 EDO05444.1 - 1.2e-10 40.9 7.5 1.2e-10 40.9 7.5 4.0 2 2 0 4 4 4 2 Major Facilitator Superfamily Connexin PF00029.19 EDO05444.1 - 0.00098 18.9 0.0 0.0026 17.6 0.0 1.7 1 0 0 1 1 1 1 Connexin S1FA PF04689.13 EDO05444.1 - 9.9 6.4 6.6 1.5 9.0 1.4 2.4 2 0 0 2 2 2 0 DNA binding protein S1FA GCV_T PF01571.21 EDO05445.1 - 3.2e-38 131.6 0.0 4.8e-38 131.0 0.0 1.3 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 EDO05445.1 - 3.2e-05 23.8 0.0 8.2e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain HSP70 PF00012.20 EDO05446.1 - 2.2e-49 168.2 14.6 2.2e-49 168.2 14.6 2.7 2 1 0 2 2 2 1 Hsp70 protein Serine_rich PF08824.10 EDO05446.1 - 0.004 17.2 2.1 0.0074 16.3 1.0 1.9 2 0 0 2 2 2 1 Serine rich protein interaction domain Sec8_exocyst PF04048.14 EDO05446.1 - 0.15 12.0 4.3 0.45 10.4 2.4 2.8 2 1 0 2 2 2 0 Sec8 exocyst complex component specific domain FHA PF00498.26 EDO05447.1 - 1.7e-12 47.5 2.0 2.8e-11 43.6 0.2 3.1 3 0 0 3 3 3 1 FHA domain RINGv PF12906.7 EDO05447.1 - 5.5e-10 39.2 7.5 5.5e-10 39.2 7.5 1.8 2 0 0 2 2 2 1 RING-variant domain Yop-YscD_cpl PF16697.5 EDO05447.1 - 0.00098 19.4 0.0 0.0032 17.7 0.0 1.8 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain FANCL_C PF11793.8 EDO05447.1 - 0.15 12.3 5.6 0.15 12.3 3.9 1.9 2 0 0 2 2 2 0 FANCL C-terminal domain zf-RING_2 PF13639.6 EDO05447.1 - 0.31 11.4 6.2 0.8 10.1 6.2 1.8 1 0 0 1 1 1 0 Ring finger domain OTCace_N PF02729.21 EDO05448.1 - 9.6e-46 155.5 0.1 1.7e-45 154.7 0.1 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 EDO05448.1 - 1.5e-32 112.9 0.0 3.8e-32 111.5 0.0 1.7 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain SPOB_a PF14689.6 EDO05449.1 - 0.04 13.6 0.1 0.32 10.7 0.0 2.7 2 0 0 2 2 2 0 Sensor_kinase_SpoOB-type, alpha-helical domain HVSL PF09749.9 EDO05450.1 - 5.2e-25 88.3 0.2 6e-25 88.1 0.2 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein 2_5_RNA_ligase2 PF13563.6 EDO05450.1 - 6.3e-06 26.2 0.0 9.1e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily Thioredoxin PF00085.20 EDO05451.1 - 2.1e-18 66.2 0.0 3e-18 65.7 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EDO05451.1 - 1.6e-05 25.3 0.0 0.0001 22.7 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EDO05451.1 - 0.00039 20.7 0.0 0.012 15.9 0.0 2.2 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_7 PF13899.6 EDO05451.1 - 0.0035 17.5 0.0 0.0065 16.6 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Phosducin PF02114.16 EDO05451.1 - 0.0097 14.9 0.0 0.013 14.4 0.0 1.1 1 0 0 1 1 1 1 Phosducin AhpC-TSA PF00578.21 EDO05451.1 - 0.061 13.3 0.0 0.095 12.6 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA family HyaE PF07449.11 EDO05451.1 - 0.07 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE OST3_OST6 PF04756.13 EDO05451.1 - 0.072 12.4 0.0 0.099 12.0 0.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Rhomboid PF01694.22 EDO05452.1 - 1.1e-15 57.9 16.7 2.5e-13 50.3 5.1 2.3 2 0 0 2 2 2 2 Rhomboid family dDENN PF03455.19 EDO05452.1 - 0.48 10.5 4.8 4.2 7.4 4.5 2.5 1 1 1 2 2 2 0 dDENN domain IMCp PF12314.8 EDO05455.1 - 6.1e-19 68.1 50.2 3.4e-12 46.5 29.4 2.8 1 1 1 2 2 2 2 Inner membrane complex protein Dopey_N PF04118.14 EDO05456.1 - 7.8e-94 314.2 4.0 2.1e-93 312.8 4.0 1.8 1 0 0 1 1 1 1 Dopey, N-terminal Bromodomain PF00439.25 EDO05457.1 - 2.1e-23 82.2 1.5 6.2e-23 80.7 1.5 1.8 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 EDO05457.1 - 2.1e-12 47.3 0.1 5.3e-12 46.0 0.1 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDO05457.1 - 5.3e-08 32.9 0.1 1.2e-07 31.7 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDO05457.1 - 3.4e-07 30.6 0.8 7.5e-07 29.5 0.8 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDO05457.1 - 0.013 15.5 0.0 0.028 14.4 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_9 PF13527.7 EDO05457.1 - 0.021 14.9 0.3 0.067 13.3 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain CIAPIN1 PF05093.13 EDO05458.1 - 6.8e-18 65.0 11.9 3.8e-17 62.7 2.7 2.3 1 1 1 2 2 2 2 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis HGTP_anticodon PF03129.20 EDO05459.1 - 1.2e-22 79.8 0.0 3.4e-21 75.2 0.0 2.8 3 0 0 3 3 3 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EDO05459.1 - 1.6e-09 38.0 0.0 3.9e-08 33.5 0.0 2.5 2 1 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) zf-DNL PF05180.12 EDO05460.1 - 3.6e-26 90.9 0.2 5.3e-26 90.3 0.2 1.2 1 0 0 1 1 1 1 DNL zinc finger MutS_V PF00488.21 EDO05463.1 - 3.7e-73 245.6 0.1 6.2e-73 244.8 0.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EDO05463.1 - 7e-29 101.4 0.3 3e-28 99.3 0.1 2.3 3 0 0 3 3 3 1 MutS domain III MutS_IV PF05190.18 EDO05463.1 - 2.1e-07 31.2 1.1 5.2e-07 29.9 1.1 1.7 1 0 0 1 1 1 1 MutS family domain IV Glyc_hyd_38C_2 PF18230.1 EDO05463.1 - 0.1 12.7 0.1 0.34 11.1 0.1 1.9 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 C-terminal sub-domain FlaC_arch PF05377.11 EDO05463.1 - 2.6 8.5 8.5 2 8.8 0.2 3.5 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) LigT_PEase PF02834.16 EDO05464.1 - 0.014 15.5 0.0 0.024 14.8 0.0 1.4 1 0 0 1 1 1 0 LigT like Phosphoesterase VESA1_N PF12785.7 EDO05465.1 - 7.1e-203 674.7 20.1 7.1e-203 674.7 20.1 1.8 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO05466.1 - 2.3e-212 705.9 21.6 2.3e-212 705.9 21.6 2.6 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 Apolipoprotein PF01442.18 EDO05466.1 - 0.0033 17.3 2.1 0.0067 16.3 2.1 1.4 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain SMBP PF16785.5 EDO05466.1 - 0.47 10.7 9.2 0.074 13.3 3.3 2.4 2 0 0 2 2 2 0 Small metal-binding protein SesA PF17107.5 EDO05466.1 - 0.64 10.2 8.6 0.18 12.0 3.6 2.6 2 1 1 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases L31 PF09784.9 EDO05466.1 - 1.3 9.5 3.7 0.68 10.4 0.6 2.1 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L31 FliE PF02049.18 EDO05466.1 - 1.5 9.0 7.0 0.23 11.6 1.9 2.2 2 1 0 2 2 2 0 Flagellar hook-basal body complex protein FliE REF PF05755.12 EDO05466.1 - 5.8 6.7 5.6 3.2 7.5 2.2 2.1 1 1 1 2 2 2 0 Rubber elongation factor protein (REF) F-box-like_2 PF13013.6 EDO05467.1 - 0.014 15.3 0.1 0.026 14.5 0.1 1.4 1 0 0 1 1 1 0 F-box-like domain TRAPPC-Trs85 PF12739.7 EDO05468.1 - 0.06 12.3 0.0 0.068 12.1 0.0 1.0 1 0 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit DUF2149 PF09919.9 EDO05468.1 - 0.14 12.4 0.0 0.22 11.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2149) VESA1_N PF12785.7 EDO05469.1 - 2.1e-150 501.7 9.2 3.1e-150 501.1 9.2 1.2 1 0 0 1 1 1 1 Variant erythrocyte surface antigen-1 Zw10 PF06248.13 EDO05469.1 - 0.09 11.3 1.4 7 5.1 0.0 2.1 2 0 0 2 2 2 0 Centromere/kinetochore Zw10 F-box-like_2 PF13013.6 EDO05470.1 - 5.6e-09 35.9 0.3 0.00092 19.2 0.0 2.4 2 0 0 2 2 2 2 F-box-like domain F-box-like_2 PF13013.6 EDO05471.1 - 1.4e-12 47.5 2.2 0.0004 20.3 0.1 3.3 2 1 1 3 3 3 3 F-box-like domain Telomerase_RBD PF12009.8 EDO05471.1 - 0.27 11.3 2.1 2.9 8.0 0.1 2.3 2 0 0 2 2 2 0 Telomerase ribonucleoprotein complex - RNA binding domain ATP-synt_E PF05680.12 EDO05471.1 - 0.3 11.4 4.4 0.58 10.5 0.2 2.3 2 0 0 2 2 2 0 ATP synthase E chain DUF4630 PF15443.6 EDO05471.1 - 0.38 10.9 1.9 5.9 7.1 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4630) VESA1_N PF12785.7 EDO05472.1 - 8.1e-184 611.8 31.4 8.1e-184 611.8 31.4 3.4 3 1 0 3 3 3 1 Variant erythrocyte surface antigen-1 Apolipoprotein PF01442.18 EDO05472.1 - 0.11 12.3 5.9 2.8 7.8 0.6 2.3 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF4164 PF13747.6 EDO05472.1 - 0.16 12.3 1.0 0.74 10.1 1.0 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) SHE3 PF17078.5 EDO05472.1 - 0.31 10.7 3.1 0.13 12.0 0.4 1.6 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 CdvA PF18822.1 EDO05472.1 - 1.4 8.8 6.8 0.76 9.6 0.5 2.7 2 0 0 2 2 2 0 CdvA-like coiled-coil domain Spc7 PF08317.11 EDO05472.1 - 1.5 7.6 10.0 0.04 12.8 2.1 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein RPW8 PF05659.11 EDO05472.1 - 1.9 8.2 4.8 0.47 10.1 0.6 2.0 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Prominin PF05478.11 EDO05472.1 - 2.1 6.2 4.2 1.7 6.5 0.3 2.4 1 1 0 2 2 2 0 Prominin VESA1_N PF12785.7 EDO05473.1 - 5.2e-219 727.8 21.2 5.2e-219 727.8 21.2 2.6 3 0 0 3 3 2 1 Variant erythrocyte surface antigen-1 Baculo_PEP_C PF04513.12 EDO05473.1 - 0.051 13.6 0.7 15 5.7 0.1 3.7 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Latarcin PF10279.9 EDO05473.1 - 0.057 13.8 1.6 0.17 12.3 0.0 2.4 2 0 0 2 2 2 0 Latarcin precursor FliJ PF02050.16 EDO05473.1 - 0.071 13.3 0.3 0.071 13.3 0.3 3.1 2 1 1 3 3 3 0 Flagellar FliJ protein RsbRD_N PF14361.6 EDO05473.1 - 0.079 13.7 4.2 0.9 10.3 0.1 3.6 3 1 0 3 3 3 0 RsbT co-antagonist protein rsbRD N-terminal domain DUF4535 PF15054.6 EDO05473.1 - 0.19 11.5 0.1 0.68 9.7 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4535) Focal_AT PF03623.13 EDO05473.1 - 0.2 11.7 5.7 0.06 13.3 2.5 1.7 2 0 0 2 2 2 0 Focal adhesion targeting region RNase_H2-Ydr279 PF09468.10 EDO05473.1 - 0.29 11.3 1.1 0.72 10.0 1.1 1.7 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) wHTH domain DUF4423 PF14394.6 EDO05473.1 - 0.29 10.8 1.1 1.3 8.7 1.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4423) DUF3810 PF12725.7 EDO05473.1 - 0.38 10.0 1.6 8.7 5.6 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3810) VASP_tetra PF08776.11 EDO05473.1 - 1.8 8.2 10.8 0.044 13.3 3.6 2.1 2 0 0 2 2 2 0 VASP tetramerisation domain ApoLp-III PF07464.11 EDO05473.1 - 1.8 8.6 15.3 5 7.2 5.3 3.3 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) DUF1515 PF07439.11 EDO05473.1 - 3.2 7.8 4.3 6.6 6.8 0.2 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1515) Apolipoprotein PF01442.18 EDO05473.1 - 5.6 6.8 13.0 1.8e+02 1.9 13.0 2.5 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain PEP-utilisers_N PF05524.13 EDO05473.1 - 5.9 7.1 6.0 5.4 7.2 0.2 2.8 1 1 0 2 2 2 0 PEP-utilising enzyme, N-terminal RPN7 PF10602.9 EDO05473.1 - 7.5 6.2 7.6 0.57 9.9 1.1 2.3 1 1 0 1 1 1 0 26S proteasome subunit RPN7 Adeno_IVa2 PF02456.15 EDO05474.1 - 0.0097 14.7 0.1 0.011 14.6 0.1 1.1 1 0 0 1 1 1 1 Adenovirus IVa2 protein BPL_LplA_LipB PF03099.19 EDO05475.1 - 7.2e-10 38.9 0.0 4.3e-08 33.1 0.0 3.4 3 1 0 3 3 3 1 Biotin/lipoate A/B protein ligase family Lip_prot_lig_C PF10437.9 EDO05475.1 - 1.2e-07 31.6 0.0 4.2e-07 29.9 0.0 1.9 1 0 0 1 1 1 1 Bacterial lipoate protein ligase C-terminus SidC_N PF18219.1 EDO05475.1 - 0.014 14.4 0.1 0.02 13.9 0.1 1.2 1 0 0 1 1 1 0 SidC N-terminal domain RCC1_2 PF13540.6 EDO05476.1 - 1.8e-05 24.4 0.2 0.01 15.6 0.0 2.5 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EDO05476.1 - 0.0078 16.8 0.1 6.8 7.4 0.0 2.5 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat CWC25 PF12542.8 EDO05477.1 - 9.8e-12 45.7 0.0 9.8e-12 45.7 0.0 3.3 4 1 0 4 4 4 1 Pre-mRNA splicing factor Pantoate_ligase PF02569.15 EDO05477.1 - 0.053 12.7 1.7 0.1 11.8 1.7 1.4 1 0 0 1 1 1 0 Pantoate-beta-alanine ligase GTP_EFTU PF00009.27 EDO05478.1 - 1.5e-20 73.5 0.4 7.5e-19 68.0 0.4 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EDO05478.1 - 1.2e-12 47.9 0.0 2.6e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 EDO05478.1 - 8.4e-09 35.5 0.0 1.7e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 EDO05478.1 - 2.4e-05 24.0 0.0 4.4e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO05478.1 - 0.00015 21.9 0.0 0.00036 20.7 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 EDO05478.1 - 0.0038 17.0 0.0 0.03 14.0 0.0 2.2 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 EDO05478.1 - 0.008 16.2 0.0 0.022 14.8 0.0 1.7 1 0 0 1 1 1 1 Dynamin family SRPRB PF09439.10 EDO05478.1 - 0.015 14.8 0.0 0.032 13.6 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EDO05478.1 - 0.019 14.5 0.0 0.093 12.3 0.0 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.5 EDO05478.1 - 0.091 12.8 0.0 0.33 11.0 0.0 1.9 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Septin PF00735.18 EDO05478.1 - 0.11 11.8 0.0 0.23 10.7 0.0 1.4 1 0 0 1 1 1 0 Septin zf-B_box PF00643.24 EDO05479.1 - 3.7e-11 43.0 20.4 7.5e-06 26.0 7.6 2.6 2 0 0 2 2 2 2 B-box zinc finger PH PF00169.29 EDO05479.1 - 2.3e-06 28.1 0.0 4.9e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 PH domain HU-CCDC81_euk_2 PF18289.1 EDO05479.1 - 0.23 11.6 0.6 5.5 7.2 0.0 2.7 3 0 0 3 3 3 0 CCDC81 eukaryotic HU domain 2 HEAT PF02985.22 EDO05480.1 - 0.023 14.9 0.3 7.3 7.1 0.1 3.7 3 0 0 3 3 3 0 HEAT repeat BSP_II PF05432.11 EDO05481.1 - 0.026 14.2 3.8 0.03 14.0 3.8 1.0 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Phe_hydrox_dim PF07976.12 EDO05481.1 - 0.09 12.8 0.0 0.1 12.6 0.0 1.2 1 0 0 1 1 1 0 Phenol hydroxylase, C-terminal dimerisation domain Actin PF00022.19 EDO05482.1 - 3.6e-75 253.1 0.0 1e-72 245.0 0.0 2.7 1 1 0 1 1 1 1 Actin NGP1NT PF08153.12 EDO05483.1 - 4.5e-32 110.9 0.5 8.6e-32 110.0 0.5 1.4 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 EDO05483.1 - 1.4e-16 60.6 0.0 5.5e-14 52.2 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase PP-binding PF00550.25 EDO05483.1 - 1.2e-07 32.0 0.1 2.4e-07 31.0 0.1 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site FeoB_N PF02421.18 EDO05483.1 - 1.6e-07 31.0 0.0 7e-05 22.4 0.0 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EDO05483.1 - 8.8e-06 25.7 0.0 2.2e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase PP-binding_2 PF14573.6 EDO05483.1 - 1.2e-05 25.4 0.4 4.1e-05 23.7 0.4 1.8 1 0 0 1 1 1 1 Acyl-carrier Arf PF00025.21 EDO05483.1 - 0.00073 19.0 0.1 0.6 9.5 0.0 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Dynamin_N PF00350.23 EDO05483.1 - 0.0017 18.5 1.5 1.6 8.8 0.1 3.8 3 1 1 4 4 4 1 Dynamin family GTP_EFTU PF00009.27 EDO05483.1 - 0.0086 15.6 0.2 1 8.9 0.1 2.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Vac7 PF12751.7 EDO05483.1 - 0.041 13.3 0.1 0.07 12.6 0.1 1.3 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 CLP1_P PF16575.5 EDO05483.1 - 0.095 12.5 0.2 0.57 9.9 0.0 2.2 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop SHS2_Rpb7-N PF03876.17 EDO05484.1 - 1.1e-09 38.5 0.0 2.1e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RRF PF01765.19 EDO05485.1 - 1.5e-25 90.0 1.0 2.4e-25 89.4 1.0 1.3 1 0 0 1 1 1 1 Ribosome recycling factor DUF883 PF05957.13 EDO05485.1 - 0.19 12.4 2.3 0.69 10.6 0.2 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Macro PF01661.21 EDO05486.1 - 0.00028 20.9 0.0 0.00055 20.0 0.0 1.5 1 0 0 1 1 1 1 Macro domain DUF866 PF05907.13 EDO05487.1 - 6.1e-33 113.9 0.0 6.8e-33 113.8 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) PepSY_like PF11396.8 EDO05487.1 - 0.092 13.3 0.0 0.21 12.2 0.0 1.6 1 0 0 1 1 1 0 Putative beta-lactamase-inhibitor-like, PepSY-like Molydop_binding PF01568.21 EDO05487.1 - 0.1 12.6 0.1 0.16 12.0 0.1 1.3 1 0 0 1 1 1 0 Molydopterin dinucleotide binding domain IP_trans PF02121.18 EDO05488.1 - 9.4e-63 212.1 0.2 1.3e-62 211.6 0.2 1.2 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein PH PF00169.29 EDO05488.1 - 1.2e-10 41.8 0.2 3.2e-10 40.4 0.2 1.7 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 EDO05488.1 - 0.0019 18.6 0.0 0.0058 17.0 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EDO05488.1 - 0.012 16.1 0.7 0.075 13.5 0.7 2.3 1 1 0 1 1 1 0 Pleckstrin homology domain EF-hand_1 PF00036.32 EDO05489.1 - 4.5e-37 122.8 8.3 1.5e-09 36.7 0.4 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EDO05489.1 - 5.9e-33 113.1 1.1 3.6e-17 62.6 0.5 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EDO05489.1 - 6.2e-29 97.4 6.3 5.1e-09 35.3 0.1 4.5 4 1 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EDO05489.1 - 2.5e-28 97.7 8.5 1.2e-14 53.9 0.3 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 EDO05489.1 - 2.8e-24 83.5 7.0 6.7e-07 28.5 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 EDO05489.1 - 5e-12 46.0 0.0 4.2e-06 27.0 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EDO05489.1 - 3.9e-09 36.4 0.2 0.00023 21.1 0.1 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EDO05489.1 - 1.2e-06 28.8 0.1 0.0017 18.6 0.0 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 EDO05489.1 - 2.1e-05 24.4 0.0 0.17 11.9 0.0 2.6 3 0 0 3 3 2 2 Uncharacterised protein family (UPF0154) Dockerin_1 PF00404.18 EDO05489.1 - 3.1e-05 24.1 1.1 0.0052 16.9 1.2 3.0 1 1 1 2 2 2 1 Dockerin type I domain EF-hand_11 PF08976.11 EDO05489.1 - 0.00012 22.9 0.0 0.00075 20.3 0.0 1.9 1 1 1 2 2 2 1 EF-hand domain Caleosin PF05042.13 EDO05489.1 - 0.00021 21.2 0.2 0.18 11.8 0.0 2.8 2 1 1 3 3 3 1 Caleosin related protein DUF3349 PF11829.8 EDO05489.1 - 0.0028 18.4 0.1 1.7 9.5 0.0 2.7 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) EFhand_Ca_insen PF08726.10 EDO05489.1 - 0.0048 17.0 0.7 0.017 15.2 0.1 2.2 2 2 0 2 2 2 1 Ca2+ insensitive EF hand DUF5580 PF17743.1 EDO05489.1 - 0.01 14.5 0.0 0.01 14.5 0.0 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5580) SapB_1 PF05184.15 EDO05489.1 - 0.017 15.1 0.3 27 4.9 0.0 3.4 3 0 0 3 3 3 0 Saposin-like type B, region 1 Fe_hyd_lg_C PF02906.14 EDO05489.1 - 0.026 14.2 0.3 0.09 12.4 0.3 1.7 1 1 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain TerB PF05099.13 EDO05489.1 - 0.028 14.4 0.1 5.2 7.0 0.0 2.3 1 1 1 2 2 2 0 Tellurite resistance protein TerB RNA_pol_Rpb4 PF03874.16 EDO05489.1 - 0.041 14.2 0.2 3.5 8.0 0.1 2.3 2 0 0 2 2 2 0 RNA polymerase Rpb4 Sigma54_CBD PF04963.13 EDO05489.1 - 0.044 13.6 0.0 0.088 12.7 0.0 1.6 1 1 0 1 1 1 0 Sigma-54 factor, core binding domain DUF853 PF05872.12 EDO05489.1 - 0.087 11.4 0.0 0.9 8.1 0.0 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF853) MotA_activ PF09114.10 EDO05489.1 - 0.15 12.2 0.1 0.82 9.8 0.0 2.0 2 0 0 2 2 2 0 Transcription factor MotA, activation domain DUF4413 PF14372.6 EDO05490.1 - 0.031 14.6 0.0 0.073 13.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) DUF3223 PF11523.8 EDO05490.1 - 0.081 13.8 0.4 5 8.1 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3223) STIMATE PF12400.8 EDO05491.1 - 3e-22 79.5 2.4 7.1e-21 75.0 2.4 2.3 1 1 0 1 1 1 1 STIMATE family DUF2207 PF09972.9 EDO05491.1 - 3.7 6.2 5.0 0.65 8.7 1.2 1.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) Ribosomal_L22 PF00237.19 EDO05492.1 - 3.1e-35 120.5 0.1 5.4e-35 119.7 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e INCENP_N PF12178.8 EDO05495.1 - 0.041 13.9 0.3 0.086 12.9 0.3 1.5 1 0 0 1 1 1 0 Chromosome passenger complex (CPC) protein INCENP N terminal FRQ PF09421.10 EDO05495.1 - 0.055 11.5 7.7 0.066 11.2 7.7 1.0 1 0 0 1 1 1 0 Frequency clock protein DUF3246 PF11596.8 EDO05495.1 - 0.16 11.4 5.3 0.2 11.1 5.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) CDC45 PF02724.14 EDO05495.1 - 0.2 9.9 5.6 0.21 9.8 5.6 1.1 1 0 0 1 1 1 0 CDC45-like protein IMCp PF12314.8 EDO05496.1 - 4.9e-23 81.2 103.7 4.4e-21 75.0 39.1 4.6 2 2 2 4 4 4 4 Inner membrane complex protein TolA_bind_tri PF16331.5 EDO05497.1 - 0.015 15.4 1.1 0.015 15.4 1.1 5.2 4 1 0 4 4 4 0 TolA binding protein trimerisation FGGY_N PF00370.21 EDO05498.1 - 1e-62 211.9 0.5 1.6e-62 211.3 0.5 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 EDO05498.1 - 1.6e-45 155.3 0.0 2.5e-45 154.7 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 EDO05498.1 - 0.026 14.0 0.0 3 7.2 0.0 2.2 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family Pox_A14 PF05767.12 EDO05499.1 - 0.02 15.0 0.1 0.02 15.0 0.1 2.1 1 1 1 2 2 2 0 Poxvirus virion envelope protein A14 Pkinase PF00069.25 EDO05500.1 - 6.4e-60 202.8 0.0 8.8e-60 202.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO05500.1 - 1e-33 116.7 0.0 1.8e-31 109.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EDO05500.1 - 1.7e-08 34.2 0.0 2.5e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EDO05500.1 - 0.00083 19.3 0.1 0.012 15.6 0.1 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 EDO05500.1 - 0.047 13.0 0.2 0.078 12.3 0.2 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EDO05500.1 - 0.13 11.2 0.2 0.18 10.7 0.2 1.1 1 0 0 1 1 1 0 Haspin like kinase domain DEAD PF00270.29 EDO05501.1 - 2.4e-50 170.7 0.1 7.9e-50 169.0 0.1 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO05501.1 - 1.6e-26 92.8 0.0 1.2e-25 90.0 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO05501.1 - 1.6e-06 28.3 0.0 2.8e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EDO05501.1 - 1e-05 24.9 0.0 1.7e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_30 PF13604.6 EDO05501.1 - 0.0088 15.8 0.0 0.058 13.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain DUF4242 PF14026.6 EDO05501.1 - 0.027 14.6 0.0 0.068 13.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4242) AAA_22 PF13401.6 EDO05501.1 - 0.04 14.2 0.1 0.12 12.7 0.1 1.9 1 1 0 1 1 1 0 AAA domain FAINT PF04385.15 EDO05502.1 - 2.5e-22 78.7 9.8 2e-06 27.7 0.9 6.6 6 0 0 6 6 6 6 Domain of unknown function, DUF529 DEAD PF00270.29 EDO05503.1 - 2.7e-50 170.6 0.1 8.8e-50 168.9 0.1 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO05503.1 - 1.8e-26 92.7 0.0 1.3e-25 89.9 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO05503.1 - 1.7e-06 28.2 0.0 3.1e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EDO05503.1 - 1.1e-05 24.8 0.0 1.8e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_19 PF13245.6 EDO05503.1 - 0.0059 16.9 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDO05503.1 - 0.0099 15.6 0.0 0.062 13.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain DUF4242 PF14026.6 EDO05503.1 - 0.027 14.6 0.0 0.072 13.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4242) AAA_22 PF13401.6 EDO05503.1 - 0.039 14.2 0.5 0.13 12.5 0.0 2.1 2 1 0 2 2 2 0 AAA domain LSM PF01423.22 EDO05504.1 - 4.1e-17 61.6 0.3 6.2e-17 61.1 0.3 1.2 1 0 0 1 1 1 1 LSM domain zf-C3H2C3 PF17122.5 EDO05505.1 - 3.2e-06 27.1 11.2 3.2e-06 27.1 11.2 2.3 2 0 0 2 2 2 1 Zinc-finger Vps39_2 PF10367.9 EDO05505.1 - 0.016 15.6 1.5 0.033 14.6 1.5 1.6 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 zf-C3HC4_2 PF13923.6 EDO05505.1 - 0.092 12.6 11.2 0.21 11.4 11.2 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EDO05505.1 - 3.5 8.0 7.1 10 6.5 7.1 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain V-SNARE_C PF12352.8 EDO05506.1 - 0.00047 20.4 8.0 0.0012 19.1 1.4 2.5 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus NPV_P10 PF05531.12 EDO05506.1 - 0.00097 19.5 10.2 0.29 11.6 0.4 2.6 2 1 0 2 2 2 2 Nucleopolyhedrovirus P10 protein DUF4407 PF14362.6 EDO05506.1 - 0.0039 16.6 2.6 0.0049 16.3 2.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) HIP1_clath_bdg PF16515.5 EDO05506.1 - 0.0082 16.7 5.2 0.31 11.7 0.4 2.5 2 0 0 2 2 2 1 Clathrin-binding domain of Huntingtin-interacting protein 1 MitMem_reg PF13012.6 EDO05506.1 - 0.0093 16.4 3.9 0.5 10.8 0.5 2.6 1 1 1 2 2 2 1 Maintenance of mitochondrial structure and function Sec20 PF03908.13 EDO05506.1 - 0.018 14.9 3.6 0.018 14.9 3.6 2.3 2 1 0 2 2 2 0 Sec20 DUF1664 PF07889.12 EDO05506.1 - 0.018 15.0 9.7 0.23 11.5 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF669 PF05037.13 EDO05506.1 - 0.024 14.7 2.1 0.88 9.7 0.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF669) BLOC1_2 PF10046.9 EDO05506.1 - 0.039 14.2 8.0 0.31 11.4 1.6 2.4 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.12 EDO05506.1 - 0.06 13.4 12.6 0.79 9.7 3.4 2.5 2 1 0 2 2 2 0 Laminin Domain II UPF0242 PF06785.11 EDO05506.1 - 0.092 12.8 8.5 0.1 12.7 0.8 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF769 PF05590.11 EDO05506.1 - 0.11 12.0 1.2 0.14 11.5 0.5 1.6 1 1 1 2 2 2 0 Xylella fastidiosa protein of unknown function (DUF769) Fib_alpha PF08702.10 EDO05506.1 - 0.13 12.4 11.7 1.3 9.2 2.2 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family CREPT PF16566.5 EDO05506.1 - 0.25 11.5 7.6 0.79 9.9 1.7 2.2 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DASH_Dam1 PF08653.10 EDO05506.1 - 0.26 11.1 4.8 1.6 8.6 0.5 3.1 2 1 0 2 2 2 0 DASH complex subunit Dam1 DUF948 PF06103.11 EDO05506.1 - 0.26 11.6 12.8 0.11 12.8 4.1 2.7 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF745 PF05335.13 EDO05506.1 - 0.45 10.2 9.7 2.2 8.0 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) LMBR1 PF04791.16 EDO05506.1 - 0.53 9.1 6.6 0.64 8.9 6.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DASH_Duo1 PF08651.10 EDO05506.1 - 0.62 9.9 11.1 1.7 8.5 0.7 3.3 2 2 1 3 3 3 0 DASH complex subunit Duo1 Sec34 PF04136.15 EDO05506.1 - 0.82 9.5 9.6 3.5 7.5 2.2 2.2 2 0 0 2 2 2 0 Sec34-like family MCPsignal PF00015.21 EDO05506.1 - 1 9.2 11.2 1.8 8.3 2.0 2.3 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Muted PF14942.6 EDO05506.1 - 1 9.7 10.7 0.23 11.8 1.1 2.2 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein DUF3053 PF11254.8 EDO05506.1 - 1.3 8.6 7.0 1.4 8.4 1.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3053) Sec8_exocyst PF04048.14 EDO05506.1 - 4.3 7.2 12.9 3.3 7.6 3.8 3.1 2 2 0 2 2 2 0 Sec8 exocyst complex component specific domain Peptidase_S26 PF10502.9 EDO05507.1 - 1.6e-07 31.2 0.0 2.3e-06 27.4 0.0 2.0 1 1 1 2 2 2 1 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.23 EDO05507.1 - 0.0016 18.3 0.2 0.0041 17.0 0.2 1.7 1 1 0 1 1 1 1 Peptidase S24-like ClpS PF02617.17 EDO05508.1 - 8.8e-12 44.7 1.5 1.6e-11 43.8 0.1 1.9 2 0 0 2 2 2 1 ATP-dependent Clp protease adaptor protein ClpS AP2 PF00847.20 EDO05509.1 - 4e-10 39.8 2.6 7.3e-10 38.9 2.6 1.5 1 0 0 1 1 1 1 AP2 domain OGG_N PF07934.12 EDO05510.1 - 5.2e-13 49.1 0.0 1.6e-12 47.6 0.0 1.9 1 1 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 EDO05510.1 - 6.5e-10 39.4 0.0 1e-09 38.8 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EDO05510.1 - 1.4e-07 31.0 0.0 3.7e-07 29.7 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_2 PF12826.7 EDO05510.1 - 0.17 12.0 0.0 1.3 9.2 0.0 2.3 3 0 0 3 3 3 0 Helix-hairpin-helix motif HHH_5 PF14520.6 EDO05510.1 - 0.18 12.4 0.0 0.51 11.0 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain CTP_transf_like PF01467.26 EDO05511.1 - 5.7e-39 133.6 0.0 1.7e-22 80.1 0.0 2.3 2 0 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 EDO05511.1 - 3.4e-05 23.8 3.0 0.58 10.0 0.1 3.3 2 1 0 2 2 2 2 FAD synthetase CytoC_RC PF02276.18 EDO05513.1 - 0.1 11.9 0.1 0.16 11.3 0.1 1.2 1 0 0 1 1 1 0 Photosynthetic reaction centre cytochrome C subunit HA2 PF04408.23 EDO05515.1 - 2.3e-22 79.3 0.0 4.6e-22 78.4 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EDO05515.1 - 2.1e-15 56.8 0.7 4.8e-15 55.7 0.3 1.9 2 0 0 2 2 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EDO05515.1 - 9.8e-14 51.6 0.1 2.3e-13 50.5 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDO05515.1 - 2.3e-10 40.5 0.3 5e-10 39.4 0.3 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Flavi_DEAD PF07652.14 EDO05515.1 - 8.4e-08 32.3 0.1 2e-07 31.1 0.1 1.6 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_19 PF13245.6 EDO05515.1 - 7.8e-06 26.3 0.2 1.7e-05 25.2 0.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDO05515.1 - 6.8e-05 23.2 0.2 0.00036 20.8 0.0 2.3 2 0 0 2 2 1 1 AAA domain AAA_30 PF13604.6 EDO05515.1 - 0.00051 19.8 0.1 0.00089 19.0 0.1 1.3 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EDO05515.1 - 0.0015 18.2 1.5 0.0034 17.1 0.6 2.0 2 1 0 2 2 2 1 SRP54-type protein, GTPase domain ABC_tran PF00005.27 EDO05515.1 - 0.0018 18.8 0.2 0.23 12.0 0.1 2.5 1 1 1 2 2 2 1 ABC transporter ResIII PF04851.15 EDO05515.1 - 0.0032 17.5 0.0 0.015 15.3 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 EDO05515.1 - 0.0038 16.5 0.1 0.0067 15.7 0.1 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ATPase PF06745.13 EDO05515.1 - 0.0048 16.3 0.0 0.0093 15.3 0.0 1.4 1 0 0 1 1 1 1 KaiC AAA_7 PF12775.7 EDO05515.1 - 0.014 14.9 0.6 0.027 14.0 0.1 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region cobW PF02492.19 EDO05515.1 - 0.026 14.1 0.2 0.26 10.9 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.20 EDO05515.1 - 0.027 13.5 0.0 0.062 12.3 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein PhoH PF02562.16 EDO05515.1 - 0.052 13.0 0.0 0.17 11.3 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein AAA_25 PF13481.6 EDO05515.1 - 0.069 12.7 0.1 0.27 10.8 0.1 2.0 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EDO05515.1 - 0.11 12.4 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Zeta_toxin PF06414.12 EDO05515.1 - 0.14 11.4 0.1 0.38 10.0 0.0 1.7 1 1 1 2 2 2 0 Zeta toxin DUF4231 PF14015.6 EDO05516.1 - 2 8.9 7.6 0.4 11.2 4.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) PHO4 PF01384.20 EDO05516.1 - 2 7.4 7.7 3 6.8 7.7 1.4 1 1 0 1 1 1 0 Phosphate transporter family zf-C3HC4_3 PF13920.6 EDO05518.1 - 6e-14 51.6 4.8 1.1e-13 50.8 4.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDO05518.1 - 5.3e-09 35.8 5.8 9.5e-09 35.0 5.8 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EDO05518.1 - 2.7e-07 30.8 8.7 6.7e-07 29.5 8.7 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EDO05518.1 - 1.4e-06 28.0 9.1 2.9e-06 27.1 9.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDO05518.1 - 7.7e-05 22.6 7.1 0.00016 21.5 7.1 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EDO05518.1 - 0.00014 21.7 8.7 0.00027 20.7 8.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDO05518.1 - 0.01 15.8 7.5 0.041 13.9 3.1 2.6 2 0 0 2 2 2 0 RING-type zinc-finger DZR PF12773.7 EDO05518.1 - 0.29 11.2 3.1 0.75 9.9 3.1 1.6 1 0 0 1 1 1 0 Double zinc ribbon DUF1272 PF06906.11 EDO05518.1 - 0.3 11.2 4.5 0.7 10.0 4.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-RING_4 PF14570.6 EDO05518.1 - 0.44 10.4 4.6 0.98 9.3 4.6 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 EDO05518.1 - 1.1 9.4 11.7 0.2 11.9 6.7 2.3 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 EDO05518.1 - 4.6 7.1 6.3 4.7 7.1 3.5 2.5 1 1 1 2 2 2 0 RING-like zinc finger RL10P_insert PF17777.1 EDO05519.1 - 2.6e-25 88.2 0.0 4.3e-25 87.5 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 EDO05519.1 - 3.3e-11 43.2 0.1 5.5e-11 42.5 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 tRNA-synt_1d PF00750.19 EDO05520.1 - 2.4e-58 197.8 0.0 3.4e-34 118.4 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (R) DALR_1 PF05746.15 EDO05520.1 - 3.3e-16 59.5 0.6 6.3e-16 58.6 0.1 1.8 2 0 0 2 2 2 1 DALR anticodon binding domain DUF2279 PF10043.9 EDO05520.1 - 0.079 13.7 0.0 0.36 11.6 0.0 2.1 2 0 0 2 2 2 0 Predicted periplasmic lipoprotein (DUF2279) Utp12 PF04003.12 EDO05521.1 - 2.9e-15 56.5 0.5 4.7e-15 55.8 0.5 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family Ribosomal_L36 PF00444.18 EDO05521.1 - 9.3e-06 25.8 0.1 9.3e-06 25.8 0.1 2.3 2 0 0 2 2 2 1 Ribosomal protein L36 CLTH PF10607.9 EDO05522.1 - 1.3e-19 70.5 0.8 1.3e-19 70.5 0.8 1.7 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain CCDC144C PF14915.6 EDO05522.1 - 0.0074 15.4 0.0 0.014 14.5 0.0 1.4 1 0 0 1 1 1 1 CCDC144C protein coiled-coil region Utp11 PF03998.13 EDO05523.1 - 4.2e-29 102.2 11.1 5.6e-29 101.8 11.1 1.2 1 0 0 1 1 1 1 Utp11 protein SLATT_5 PF18160.1 EDO05523.1 - 0.02 14.2 0.3 0.02 14.2 0.3 1.6 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 Dala_Dala_lig_N PF01820.21 EDO05523.1 - 0.056 13.9 0.0 0.17 12.3 0.0 1.7 1 0 0 1 1 1 0 D-ala D-ala ligase N-terminus MutS_V PF00488.21 EDO05524.1 - 1e-69 234.3 0.2 2.2e-69 233.3 0.2 1.5 1 0 0 1 1 1 1 MutS domain V MutS_I PF01624.20 EDO05524.1 - 1.1e-31 109.4 0.0 2.8e-31 108.1 0.0 1.8 1 0 0 1 1 1 1 MutS domain I MutS_III PF05192.18 EDO05524.1 - 6.7e-28 98.2 0.8 1.4e-27 97.2 0.2 1.9 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.17 EDO05524.1 - 0.076 13.3 0.0 0.21 11.9 0.0 1.7 1 0 0 1 1 1 0 MutS domain II AAA_28 PF13521.6 EDO05524.1 - 0.11 12.8 0.4 7.2 6.8 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EDO05524.1 - 0.14 12.6 0.0 0.53 10.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain SRP72 PF08492.12 EDO05525.1 - 1.1e-08 35.4 2.4 1.1e-08 35.4 2.4 2.2 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_2 PF07719.17 EDO05525.1 - 1.2e-08 34.4 1.3 0.017 15.2 0.1 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDO05525.1 - 4.6e-06 27.1 0.0 0.015 15.8 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDO05525.1 - 1.3e-05 25.1 0.5 0.12 12.6 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO05525.1 - 4e-05 23.8 13.0 0.19 12.0 0.0 5.3 5 0 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 SRP_TPR_like PF17004.5 EDO05525.1 - 5.1e-05 23.3 0.4 0.14 12.2 0.0 3.6 3 1 0 3 3 3 2 Putative TPR-like repeat TPR_14 PF13428.6 EDO05525.1 - 0.00015 22.3 0.0 0.13 13.2 0.0 4.8 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDO05525.1 - 0.0016 18.9 1.0 16 6.4 0.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 EDO05525.1 - 0.0024 18.1 1.5 1.1 9.6 0.1 4.5 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 EDO05525.1 - 0.008 16.0 2.1 3.4 7.6 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDO05525.1 - 0.018 15.1 0.9 0.1 12.7 0.0 2.8 3 0 0 3 3 1 0 Tetratricopeptide repeat TPR_4 PF07721.14 EDO05525.1 - 0.025 15.2 0.0 0.47 11.2 0.0 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDO05525.1 - 0.064 13.9 0.1 0.33 11.6 0.0 2.3 2 0 0 2 2 1 0 Tetratricopeptide repeat NARP1 PF12569.8 EDO05525.1 - 0.13 11.1 0.0 1.2 8.0 0.0 2.3 3 0 0 3 3 3 0 NMDA receptor-regulated protein 1 BTAD PF03704.17 EDO05525.1 - 0.27 11.7 1.7 8.5 6.8 0.0 3.4 5 0 0 5 5 4 0 Bacterial transcriptional activator domain Proteasome PF00227.26 EDO05526.1 - 5.4e-37 127.1 0.0 6.1e-37 127.0 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit PB1 PF00564.24 EDO05526.1 - 0.054 13.4 0.1 0.34 10.9 0.0 2.2 2 0 0 2 2 2 0 PB1 domain ADSL_C PF10397.9 EDO05526.1 - 0.19 12.3 0.2 2.3 8.8 0.0 2.4 2 1 0 2 2 2 0 Adenylosuccinate lyase C-terminus Band_7 PF01145.25 EDO05527.1 - 2.6e-24 86.2 0.7 2.6e-24 86.2 0.7 1.4 2 0 0 2 2 2 1 SPFH domain / Band 7 family Lactamase_B_2 PF12706.7 EDO05528.1 - 3.4e-09 36.5 0.0 6e-09 35.7 0.0 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EDO05528.1 - 4.2e-05 23.5 0.0 9.5e-05 22.3 0.0 1.7 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Cpn10 PF00166.21 EDO05529.1 - 1.5e-26 92.2 0.0 1.7e-26 92.1 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Pro_isomerase PF00160.21 EDO05530.1 - 2.7e-21 76.5 0.0 3.4e-21 76.2 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD AhpC-TSA PF00578.21 EDO05531.1 - 6.8e-29 100.3 0.0 9.2e-29 99.9 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EDO05531.1 - 1e-13 51.2 0.0 1.4e-13 50.8 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EDO05531.1 - 2.3e-05 24.2 0.0 3.9e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin AhpC-TSA_2 PF13911.6 EDO05531.1 - 0.026 14.6 0.0 0.13 12.4 0.0 2.1 2 1 0 2 2 2 0 AhpC/TSA antioxidant enzyme VESA1_N PF12785.7 EDO05532.1 - 4.3e-18 65.5 7.2 2.2e-11 43.4 0.0 5.3 4 2 1 5 5 5 3 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO05533.1 - 1.7e-219 729.4 21.6 1.7e-219 729.4 21.6 2.3 2 0 0 2 2 2 1 Variant erythrocyte surface antigen-1 APG17 PF04108.12 EDO05533.1 - 0.0086 15.2 0.5 0.02 14.1 0.5 1.6 1 0 0 1 1 1 1 Autophagy protein Apg17 Senescence PF06911.12 EDO05533.1 - 0.0088 16.4 2.9 0.4 11.0 2.3 2.8 2 1 0 2 2 2 1 Senescence-associated protein DUF5082 PF16888.5 EDO05533.1 - 0.021 15.1 0.4 0.078 13.3 0.4 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) Spc7 PF08317.11 EDO05533.1 - 0.03 13.2 3.8 0.058 12.3 3.8 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein NPV_P10 PF05531.12 EDO05533.1 - 0.038 14.5 9.1 3.4 8.2 1.8 3.6 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Spectrin PF00435.21 EDO05533.1 - 0.1 13.1 6.8 0.053 14.0 1.4 2.6 2 0 0 2 2 2 0 Spectrin repeat DUF2959 PF11172.8 EDO05533.1 - 0.16 12.1 1.6 0.65 10.1 1.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2959) Baculo_p24 PF05073.12 EDO05533.1 - 0.2 11.4 0.3 0.76 9.5 0.2 1.9 1 1 1 2 2 2 0 Baculovirus P24 capsid protein SesA PF17107.5 EDO05533.1 - 0.4 10.9 9.8 0.089 13.0 4.3 2.7 2 1 1 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases CAGE1 PF15066.6 EDO05533.1 - 0.45 9.1 5.1 0.14 10.8 0.1 2.0 2 0 0 2 2 2 0 Cancer-associated gene protein 1 family PHM7_cyt PF14703.6 EDO05533.1 - 4 7.6 5.0 2.1 8.5 2.1 2.0 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter BACK PF07707.15 EDO05534.1 - 0.025 14.6 0.0 0.14 12.3 0.0 2.2 1 1 1 2 2 2 0 BTB And C-terminal Kelch Sde2_N_Ubi PF13019.6 EDO05536.1 - 9.5e-13 48.3 1.3 1.7e-12 47.5 1.3 1.4 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain PRELI PF04707.14 EDO05537.1 - 1.1e-09 38.4 0.2 1.2e-09 38.2 0.2 1.0 1 0 0 1 1 1 1 PRELI-like family DUF4239 PF14023.6 EDO05537.1 - 0.12 12.0 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) zf-CSL PF05207.13 EDO05538.1 - 1.4e-16 59.9 0.8 1.9e-16 59.5 0.8 1.2 1 0 0 1 1 1 1 CSL zinc finger zf-like PF04071.12 EDO05538.1 - 0.043 13.7 0.6 0.069 13.1 0.6 1.3 1 0 0 1 1 1 0 Cysteine-rich small domain MMR_HSR1 PF01926.23 EDO05539.1 - 7.7e-29 100.1 0.2 4.9e-21 74.9 0.0 2.3 2 0 0 2 2 2 2 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDO05539.1 - 4.4e-14 52.5 0.5 2.6e-08 33.6 0.0 3.5 2 2 0 2 2 2 2 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EDO05539.1 - 1.3e-11 44.3 0.1 4.8e-10 39.2 0.2 2.5 2 1 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EDO05539.1 - 7.6e-07 29.3 0.6 0.02 14.9 0.3 3.1 2 1 1 3 3 3 2 Dynamin family cobW PF02492.19 EDO05539.1 - 8.5e-06 25.5 0.1 3e-05 23.7 0.0 1.8 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AIG1 PF04548.16 EDO05539.1 - 3.3e-05 23.3 0.2 0.01 15.2 0.1 2.2 2 0 0 2 2 2 2 AIG1 family RsgA_GTPase PF03193.16 EDO05539.1 - 5.1e-05 23.2 1.0 0.07 13.0 0.2 2.8 1 1 1 2 2 2 2 RsgA GTPase Ras PF00071.22 EDO05539.1 - 0.0001 22.0 0.0 0.0049 16.5 0.0 2.6 2 1 0 2 2 2 1 Ras family Roc PF08477.13 EDO05539.1 - 0.00017 21.8 0.1 0.12 12.6 0.0 2.7 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EDO05539.1 - 0.0078 15.7 0.1 0.13 11.6 0.0 2.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Ligase_CoA PF00549.19 EDO05539.1 - 0.016 15.0 0.7 0.11 12.3 0.1 2.4 3 0 0 3 3 3 0 CoA-ligase ABC_tran PF00005.27 EDO05539.1 - 0.024 15.2 0.1 0.043 14.3 0.1 1.6 1 1 0 1 1 1 0 ABC transporter DUF4062 PF13271.6 EDO05539.1 - 0.15 12.5 0.0 7 7.1 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4062) Endosulfine PF04667.17 EDO05540.1 - 1.4 9.1 6.2 0.26 11.5 1.1 2.6 2 1 0 2 2 2 0 cAMP-regulated phosphoprotein/endosulfine conserved region Prenyltrans PF00432.21 EDO05541.1 - 8.1e-45 150.2 5.4 4.9e-13 48.6 0.2 5.6 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 EDO05541.1 - 8.4e-10 38.2 0.0 0.026 13.6 0.0 3.4 1 1 1 3 3 3 3 Squalene-hopene cyclase N-terminal domain SQHop_cyclase_C PF13243.6 EDO05541.1 - 0.00011 21.5 0.0 0.067 12.3 0.0 3.1 1 1 2 3 3 3 3 Squalene-hopene cyclase C-terminal domain SAC3_GANP PF03399.16 EDO05542.1 - 3.6e-12 46.3 13.7 7.2e-10 38.7 13.7 3.0 1 1 0 1 1 1 1 SAC3/GANP family DDHD PF02862.17 EDO05542.1 - 0.041 14.0 0.7 0.074 13.2 0.7 1.5 1 0 0 1 1 1 0 DDHD domain Helicase_C_2 PF13307.6 EDO05543.1 - 3.3e-41 141.3 0.0 1.1e-40 139.6 0.0 1.9 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 EDO05543.1 - 5e-34 117.4 3.4 1.5e-33 115.9 3.4 1.8 1 1 0 1 1 1 1 DEAD_2 DEAD PF00270.29 EDO05543.1 - 0.00012 22.0 0.0 0.17 11.7 0.0 2.8 2 1 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 EDO05543.1 - 0.00025 21.1 0.0 0.27 11.2 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit HBB PF06777.11 EDO05543.1 - 0.0074 16.0 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 Helical and beta-bridge domain AAA PF00004.29 EDO05543.1 - 0.018 15.4 0.0 0.47 10.9 0.0 2.9 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) SNF2_N PF00176.23 EDO05543.1 - 0.021 13.6 0.0 0.04 12.6 0.0 1.4 1 0 0 1 1 1 0 SNF2 family N-terminal domain ESCRT-II PF05871.12 EDO05544.1 - 6.6e-17 62.1 0.1 5.5e-16 59.1 0.0 2.3 1 1 1 2 2 2 1 ESCRT-II complex subunit DDRGK PF09756.9 EDO05545.1 - 1.2e-55 188.1 20.2 1.4e-55 187.8 20.2 1.1 1 0 0 1 1 1 1 DDRGK domain DUF2254 PF10011.9 EDO05545.1 - 0.0043 15.9 1.2 0.014 14.3 1.2 1.7 1 1 0 1 1 1 1 Predicted membrane protein (DUF2254) Atg14 PF10186.9 EDO05545.1 - 0.0079 15.3 10.6 0.0098 15.0 10.6 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4407 PF14362.6 EDO05545.1 - 0.0088 15.4 5.0 0.012 14.9 5.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) MVP_shoulder PF11978.8 EDO05545.1 - 0.03 14.3 0.1 0.054 13.5 0.1 1.4 1 0 0 1 1 1 0 Shoulder domain Peptidase_S49_N PF08496.10 EDO05545.1 - 0.057 13.5 18.0 2 8.5 17.8 2.1 1 1 1 2 2 2 0 Peptidase family S49 N-terminal Zip PF02535.22 EDO05545.1 - 0.057 12.6 0.9 0.068 12.4 0.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter PA26 PF04636.13 EDO05545.1 - 0.072 12.0 6.2 0.09 11.7 6.2 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DDHD PF02862.17 EDO05545.1 - 0.079 13.1 2.2 0.1 12.7 2.2 1.2 1 0 0 1 1 1 0 DDHD domain PPL5 PF18168.1 EDO05545.1 - 0.1 11.9 4.7 0.12 11.6 4.7 1.2 1 0 0 1 1 1 0 Prim-pol family 5 Neur_chan_memb PF02932.16 EDO05545.1 - 0.12 12.4 2.5 0.17 11.9 2.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2756 PF10956.8 EDO05545.1 - 0.26 11.8 3.7 0.38 11.3 3.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2756) eIF3_subunit PF08597.10 EDO05545.1 - 0.36 10.7 21.0 0.49 10.3 21.0 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit SOBP PF15279.6 EDO05545.1 - 2.8 8.5 4.6 3.5 8.2 4.6 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein BPL_N PF09825.9 EDO05545.1 - 3.6 6.6 8.0 4.8 6.2 8.0 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal V_ATPase_I PF01496.19 EDO05545.1 - 4.9 4.9 10.4 6 4.7 10.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3332 PF11810.8 EDO05545.1 - 6.7 6.3 9.4 7.5 6.2 5.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3332) RR_TM4-6 PF06459.12 EDO05545.1 - 7 6.4 16.0 9.4 6.0 16.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PolyA_pol PF01743.20 EDO05546.1 - 2.7e-28 98.9 0.1 6.2e-28 97.8 0.1 1.6 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EDO05546.1 - 0.00069 19.3 0.0 0.0015 18.3 0.0 1.5 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A LnmK_N_HDF PF18238.1 EDO05548.1 - 0.11 12.2 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 LnmK N-terminal Hot Dog Fold domain DHHC PF01529.20 EDO05549.1 - 4.2e-30 104.6 16.7 4.9e-30 104.4 16.7 1.1 1 0 0 1 1 1 1 DHHC palmitoyltransferase MspA PF09203.11 EDO05549.1 - 0.22 11.4 0.1 0.28 11.0 0.1 1.1 1 0 0 1 1 1 0 MspA Pkinase PF00069.25 EDO05550.1 - 5.7e-61 206.2 0.0 1.3e-60 205.0 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.29 EDO05550.1 - 2.1e-60 200.8 0.1 1.1e-17 63.8 0.0 4.5 4 0 0 4 4 4 4 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 EDO05550.1 - 2.2e-29 102.5 0.0 3.9e-29 101.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO05550.1 - 5.2e-05 22.7 0.0 0.00011 21.6 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Cupin_2 PF07883.11 EDO05550.1 - 0.00018 21.1 1.5 1.4 8.6 0.0 3.8 4 0 0 4 4 4 1 Cupin domain Kdo PF06293.14 EDO05550.1 - 0.0096 15.3 0.0 0.022 14.1 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDO05550.1 - 0.011 15.6 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EDO05550.1 - 0.012 14.5 0.0 0.022 13.6 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 EDO05550.1 - 0.021 13.7 0.0 0.041 12.8 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 EDO05550.1 - 0.022 13.8 0.1 0.7 8.9 0.0 2.6 3 0 0 3 3 3 0 Seadornavirus VP7 Flu_B_M2 PF04772.12 EDO05550.1 - 0.13 12.5 2.2 0.64 10.3 0.7 2.6 2 0 0 2 2 2 0 Influenza B matrix protein 2 (BM2) DUF3316 PF11777.8 EDO05551.1 - 0.029 14.4 0.1 0.088 12.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3316) Zip PF02535.22 EDO05552.1 - 1.2e-17 64.2 9.4 1.9e-17 63.5 9.4 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter DctQ PF04290.12 EDO05552.1 - 0.00025 20.9 2.6 0.00062 19.7 2.6 1.7 1 0 0 1 1 1 1 Tripartite ATP-independent periplasmic transporters, DctQ component DUF1385 PF07136.11 EDO05552.1 - 0.087 12.1 1.6 0.12 11.7 0.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1385) DPM3 PF08285.11 EDO05552.1 - 0.12 12.6 0.5 0.12 12.6 0.5 2.8 3 1 0 3 3 3 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) DUF997 PF06196.12 EDO05552.1 - 0.98 9.5 3.6 0.82 9.7 1.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF997) Cyt-b5 PF00173.28 EDO05553.1 - 1.9e-23 82.4 0.0 2.3e-23 82.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain CotJB PF12652.7 EDO05553.1 - 0.012 15.8 0.2 0.46 10.7 0.0 2.2 1 1 1 2 2 2 0 CotJB protein MHB PF16525.5 EDO05553.1 - 0.094 13.0 0.0 18 5.7 0.0 2.2 1 1 1 2 2 2 0 Haemophore, haem-binding R2K_3 PF14243.6 EDO05553.1 - 0.11 12.5 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 3 Ribosomal_L3 PF00297.22 EDO05554.1 - 8.2e-15 54.7 0.2 1.4e-14 53.9 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L3 RRM_1 PF00076.22 EDO05555.1 - 5.9e-12 45.2 0.0 7.4e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDO05555.1 - 0.0016 18.4 0.1 0.0056 16.7 0.0 1.8 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EDO05555.1 - 0.016 15.3 0.0 0.036 14.2 0.0 1.5 1 1 0 1 1 1 0 RNA recognition motif RRM_1 PF00076.22 EDO05556.1 - 9.3e-14 51.0 0.0 1.6e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO05556.1 - 0.027 14.6 0.0 0.055 13.6 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif Nup35_RRM_2 PF14605.6 EDO05556.1 - 0.039 14.0 0.0 0.063 13.3 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif LSM PF01423.22 EDO05557.1 - 1.6e-11 43.7 0.0 2.6e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 LSM domain Telomerase_RBD PF12009.8 EDO05561.1 - 1.3e-28 99.8 0.6 3.2e-28 98.5 0.6 1.7 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 EDO05561.1 - 3.3e-07 30.1 0.1 0.00023 20.8 0.0 2.8 3 0 0 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4417 PF14386.6 EDO05561.1 - 0.096 12.3 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4417) Macro PF01661.21 EDO05562.1 - 6.8e-05 22.9 0.0 0.00016 21.7 0.0 1.6 1 0 0 1 1 1 1 Macro domain Nckap1 PF09735.9 EDO05562.1 - 0.0076 14.3 0.0 0.0096 13.9 0.0 1.1 1 0 0 1 1 1 1 Membrane-associated apoptosis protein Peptidase_S39 PF02122.15 EDO05562.1 - 0.13 11.8 0.0 1.5 8.4 0.0 2.1 2 0 0 2 2 2 0 Peptidase S39 AmpE PF17113.5 EDO05563.1 - 0.039 13.3 0.1 0.044 13.1 0.1 1.1 1 0 0 1 1 1 0 Regulatory signalling modulator protein AmpE SieB PF14163.6 EDO05563.1 - 0.059 12.9 0.1 0.092 12.2 0.1 1.4 1 1 0 1 1 1 0 Super-infection exclusion protein B DUF1129 PF06570.11 EDO05563.1 - 0.17 11.4 0.0 0.21 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) FYVE PF01363.21 EDO05564.1 - 0.052 13.7 5.4 0.13 12.4 5.4 1.7 1 0 0 1 1 1 0 FYVE zinc finger zf-Sec23_Sec24 PF04810.15 EDO05564.1 - 1.1 9.4 8.9 0.14 12.2 2.8 2.5 2 1 1 3 3 3 0 Sec23/Sec24 zinc finger AP2 PF00847.20 EDO05566.1 - 1.5e-44 150.0 16.4 2.5e-15 56.4 0.4 3.4 3 0 0 3 3 3 3 AP2 domain DUF1610 PF07754.11 EDO05567.1 - 0.0018 18.2 4.5 0.015 15.3 4.5 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF1610) Zn_Tnp_IS1595 PF12760.7 EDO05567.1 - 0.0048 16.8 0.4 0.25 11.3 0.1 2.3 2 0 0 2 2 2 1 Transposase zinc-ribbon domain Rubredoxin PF00301.20 EDO05567.1 - 0.0049 16.9 3.3 0.35 10.9 3.3 2.3 1 1 0 1 1 1 1 Rubredoxin Headcase PF16002.5 EDO05567.1 - 0.012 15.1 0.4 0.018 14.5 0.4 1.2 1 0 0 1 1 1 0 Headcase protein zf-Mss51 PF13824.6 EDO05567.1 - 0.021 14.9 1.8 3 8.0 0.1 2.2 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zinc_ribbon_10 PF10058.9 EDO05567.1 - 0.023 14.4 0.4 3.4 7.5 0.1 2.3 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein OrfB_Zn_ribbon PF07282.11 EDO05567.1 - 0.067 13.1 2.1 0.77 9.7 0.2 2.2 1 1 1 2 2 2 0 Putative transposase DNA-binding domain TFIIS_C PF01096.18 EDO05567.1 - 0.086 12.7 1.3 8.3 6.4 0.2 2.3 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zf-nanos PF05741.13 EDO05567.1 - 0.1 12.8 0.7 5.6 7.3 0.1 2.2 2 0 0 2 2 2 0 Nanos RNA binding domain HypA PF01155.19 EDO05567.1 - 0.13 12.3 0.7 0.25 11.4 0.7 1.6 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF35_N PF12172.8 EDO05567.1 - 0.13 12.2 3.9 1.1 9.2 0.3 2.3 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Zn-ribbon_8 PF09723.10 EDO05567.1 - 0.24 11.6 3.3 0.62 10.2 3.3 1.7 1 1 0 1 1 1 0 Zinc ribbon domain zf-RING_7 PF02591.15 EDO05567.1 - 1.3 9.3 4.9 34 4.7 4.9 2.4 1 1 0 1 1 1 0 C4-type zinc ribbon domain zf-C2H2 PF00096.26 EDO05567.1 - 1.4 9.5 3.2 26 5.5 0.3 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type TF_Zn_Ribbon PF08271.12 EDO05567.1 - 3 7.4 5.0 1.2 8.7 0.3 2.0 1 1 2 3 3 3 0 TFIIB zinc-binding CpXC PF14353.6 EDO05567.1 - 3.9 7.5 5.1 10 6.2 0.5 2.6 2 1 1 3 3 3 0 CpXC protein Ribonuc_red_lgC PF02867.15 EDO05568.1 - 1.2e-185 618.0 0.0 1.7e-185 617.5 0.0 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 EDO05568.1 - 1e-22 79.9 0.0 2.9e-22 78.5 0.0 1.8 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 EDO05568.1 - 6e-12 46.0 0.0 1.5e-11 44.7 0.0 1.8 1 0 0 1 1 1 1 ATP cone domain Pyrid_oxidase_2 PF13883.6 EDO05569.1 - 0.07 13.1 0.3 0.14 12.1 0.3 1.4 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase MoeA_C PF03454.15 EDO05571.1 - 0.17 12.1 0.0 0.43 10.8 0.0 1.7 1 0 0 1 1 1 0 MoeA C-terminal region (domain IV) HIT PF01230.23 EDO05572.1 - 1e-20 74.3 0.1 1.8e-20 73.5 0.1 1.3 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EDO05572.1 - 8.1e-05 23.1 0.0 0.00018 21.9 0.0 1.6 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Peptidase_M30 PF10460.9 EDO05572.1 - 0.021 13.8 0.0 0.028 13.4 0.0 1.1 1 0 0 1 1 1 0 Peptidase M30 DEAD PF00270.29 EDO05573.1 - 1.9e-46 158.0 0.0 3.9e-46 157.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO05573.1 - 8.4e-28 96.9 0.0 1e-26 93.5 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO05573.1 - 0.0033 17.4 0.3 0.025 14.6 0.0 2.7 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDO05573.1 - 0.0052 17.1 1.1 0.89 9.8 0.0 3.3 3 1 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EDO05573.1 - 0.015 15.0 0.0 0.09 12.5 0.0 2.3 2 1 0 2 2 2 0 AAA domain RCC1 PF00415.18 EDO05574.1 - 1.9e-32 111.6 20.8 8e-12 45.6 0.2 5.2 5 1 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EDO05574.1 - 7.7e-12 44.7 26.7 9.1e-06 25.3 2.0 5.5 5 1 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EDO05575.1 - 5.5e-63 209.4 20.8 1.3e-13 51.3 0.1 12.1 12 1 0 12 12 12 9 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EDO05575.1 - 1.4e-33 114.0 48.7 1.7e-07 30.9 0.2 10.1 10 0 0 10 10 10 9 Regulator of chromosome condensation (RCC1) repeat TPT PF03151.16 EDO05576.1 - 8.6e-89 297.7 23.4 1.1e-88 297.4 23.4 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EDO05576.1 - 3.6e-13 49.8 33.4 1.8e-08 34.7 15.1 2.4 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 EDO05576.1 - 0.0011 18.3 21.0 0.0014 17.9 21.0 1.2 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.16 EDO05577.1 - 6.3e-78 262.1 15.8 7.5e-78 261.8 15.8 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EDO05577.1 - 2.6e-15 56.8 23.0 6.9e-08 32.7 9.8 2.2 2 0 0 2 2 2 2 EamA-like transporter family DUF3899 PF13038.6 EDO05577.1 - 0.02 15.4 8.0 0.078 13.5 0.3 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3899) UAA PF08449.11 EDO05577.1 - 1.3 8.1 16.5 5.5 6.1 16.5 2.4 1 1 0 1 1 1 0 UAA transporter family TPT PF03151.16 EDO05578.1 - 1.5e-73 247.7 23.5 1.7e-73 247.5 23.5 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EDO05578.1 - 3.4e-10 40.2 32.0 1.1e-06 28.8 14.8 2.2 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 EDO05578.1 - 0.013 14.8 19.9 0.039 13.2 19.1 2.0 1 1 0 1 1 1 0 UAA transporter family Pyr_redox_2 PF07992.14 EDO05579.1 - 5.7e-40 137.4 0.0 7.4e-40 137.0 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDO05579.1 - 2.3e-05 24.9 0.0 0.00016 22.2 0.2 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Ank_2 PF12796.7 EDO05580.1 - 2.2e-24 85.8 2.2 1.4e-13 51.2 0.2 4.1 2 2 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDO05580.1 - 1.3e-12 48.0 2.4 2.8e-05 24.6 0.1 4.6 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDO05580.1 - 5.8e-12 44.7 0.5 0.003 17.9 0.0 5.7 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 EDO05580.1 - 1e-09 38.4 6.2 0.00019 21.7 0.1 5.5 6 0 0 6 6 6 2 Ankyrin repeat Ank_5 PF13857.6 EDO05580.1 - 3.6e-09 36.7 1.1 3.5e-05 24.0 0.2 4.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) MHB PF16525.5 EDO05580.1 - 0.11 12.8 0.1 0.32 11.3 0.1 1.7 1 0 0 1 1 1 0 Haemophore, haem-binding DUF2183 PF09949.9 EDO05581.1 - 6.6e-06 26.4 0.0 1.5e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) PPV_E2_C PF00511.17 EDO05581.1 - 0.16 12.1 0.0 0.31 11.2 0.0 1.4 1 0 0 1 1 1 0 E2 (early) protein, C terminal RLL PF10036.9 EDO05582.1 - 8.7e-13 48.7 0.0 9.4e-13 48.6 0.0 1.0 1 0 0 1 1 1 1 RNA transcription, translation and transport factor protein Trp_repressor PF01371.19 EDO05583.1 - 0.056 13.6 0.1 0.18 11.9 0.1 1.8 1 0 0 1 1 1 0 Trp repressor protein Sld5 PF05916.11 EDO05584.1 - 6.4e-06 26.6 0.0 1.1e-05 25.8 0.0 1.5 1 1 0 1 1 1 1 GINS complex protein MFS_1 PF07690.16 EDO05585.1 - 6.6e-16 58.2 21.8 6.6e-16 58.2 21.8 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily UQ_con PF00179.26 EDO05586.1 - 4.7e-42 143.0 0.0 5.4e-42 142.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDO05586.1 - 0.026 14.2 0.0 0.03 14.0 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B UQ_con PF00179.26 EDO05587.1 - 4.7e-42 143.0 0.0 5.4e-42 142.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDO05587.1 - 0.026 14.2 0.0 0.03 14.0 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B MFS_1 PF07690.16 EDO05588.1 - 6.6e-16 58.2 21.8 6.6e-16 58.2 21.8 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sld5 PF05916.11 EDO05589.1 - 6.4e-06 26.6 0.0 1.1e-05 25.8 0.0 1.5 1 1 0 1 1 1 1 GINS complex protein Elf1 PF05129.13 EDO05590.1 - 1.6e-22 79.3 1.3 1.6e-22 79.3 1.3 1.6 2 0 0 2 2 2 1 Transcription elongation factor Elf1 like Vps36-NZF-N PF16988.5 EDO05590.1 - 0.0035 16.7 0.0 0.0069 15.7 0.0 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain Trp_repressor PF01371.19 EDO05591.1 - 0.061 13.5 0.1 0.14 12.3 0.1 1.6 1 0 0 1 1 1 0 Trp repressor protein VESA1_N PF12785.7 EDO05592.1 - 4e-162 540.3 13.2 4e-162 540.3 13.2 3.3 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 WEMBL PF05701.11 EDO05592.1 - 0.024 13.4 11.4 0.029 13.1 10.4 1.5 1 1 1 2 2 2 0 Weak chloroplast movement under blue light TBCA PF02970.16 EDO05592.1 - 0.048 14.0 2.1 0.23 11.8 2.1 2.2 1 0 0 1 1 1 0 Tubulin binding cofactor A DDE_Tnp_1_assoc PF13808.6 EDO05592.1 - 0.082 12.9 0.0 0.29 11.2 0.0 1.9 1 0 0 1 1 1 0 DDE_Tnp_1-associated Spc7 PF08317.11 EDO05592.1 - 0.097 11.5 8.2 0.22 10.4 8.2 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein APG17 PF04108.12 EDO05592.1 - 8.5 5.4 9.1 4.5 6.3 3.6 2.1 1 1 1 2 2 2 0 Autophagy protein Apg17 VESA1_N PF12785.7 EDO05594.1 - 1.7e-16 60.3 8.4 7.6e-10 38.4 0.0 4.9 4 1 1 5 5 5 3 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO05595.1 - 5.2e-218 724.5 21.6 5.2e-218 724.5 21.6 2.3 2 0 0 2 2 2 1 Variant erythrocyte surface antigen-1 Senescence PF06911.12 EDO05595.1 - 0.0019 18.5 3.7 0.065 13.5 2.9 2.7 2 0 0 2 2 2 1 Senescence-associated protein APG17 PF04108.12 EDO05595.1 - 0.0056 15.8 0.8 0.013 14.7 0.8 1.6 1 0 0 1 1 1 1 Autophagy protein Apg17 Spectrin PF00435.21 EDO05595.1 - 0.0072 16.8 3.3 0.0072 16.8 3.3 2.6 2 0 0 2 2 2 1 Spectrin repeat BAR PF03114.18 EDO05595.1 - 0.013 15.2 3.2 0.038 13.6 3.2 1.9 1 0 0 1 1 1 0 BAR domain Spc7 PF08317.11 EDO05595.1 - 0.015 14.2 6.2 0.029 13.3 6.2 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF5082 PF16888.5 EDO05595.1 - 0.021 15.1 0.8 0.078 13.3 0.8 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) BAR_2 PF10455.9 EDO05595.1 - 0.024 13.8 7.2 0.8 8.8 3.0 2.2 2 0 0 2 2 2 0 Bin/amphiphysin/Rvs domain for vesicular trafficking Arfaptin PF06456.13 EDO05595.1 - 0.028 14.0 0.3 0.064 12.8 0.3 1.6 1 0 0 1 1 1 0 Arfaptin-like domain NPV_P10 PF05531.12 EDO05595.1 - 0.029 14.8 10.7 2.4 8.7 1.6 3.6 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein TSNAXIP1_N PF15739.5 EDO05595.1 - 0.035 14.5 0.1 0.11 12.9 0.1 1.9 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus Baculo_p24 PF05073.12 EDO05595.1 - 0.086 12.6 0.5 0.26 11.1 0.3 1.9 1 1 1 2 2 2 0 Baculovirus P24 capsid protein ERM PF00769.19 EDO05595.1 - 0.094 12.5 5.0 0.2 11.4 5.0 1.5 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF2959 PF11172.8 EDO05595.1 - 0.15 12.2 3.5 0.53 10.4 2.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2959) Sec8_exocyst PF04048.14 EDO05595.1 - 0.18 11.7 3.8 0.14 12.1 0.6 2.2 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain AIP3 PF03915.13 EDO05595.1 - 0.18 10.8 5.4 0.32 10.0 5.4 1.3 1 0 0 1 1 1 0 Actin interacting protein 3 DUF3987 PF13148.6 EDO05595.1 - 0.23 10.4 2.5 0.39 9.7 2.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) SesA PF17107.5 EDO05595.1 - 0.38 10.9 10.6 0.12 12.5 4.7 2.9 2 1 1 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases YkyA PF10368.9 EDO05595.1 - 0.48 10.1 9.2 0.1 12.3 5.1 1.9 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein GARP PF16731.5 EDO05595.1 - 0.8 9.4 12.3 0.77 9.4 10.3 1.9 1 1 0 1 1 1 0 Glutamic acid/alanine-rich protein of Trypanosoma LemA PF04011.12 EDO05595.1 - 1.1 9.0 3.6 2.7 7.8 3.5 1.7 1 1 0 1 1 1 0 LemA family CAGE1 PF15066.6 EDO05595.1 - 1.4 7.5 9.2 0.15 10.7 0.2 2.1 2 0 0 2 2 2 0 Cancer-associated gene protein 1 family FliJ PF02050.16 EDO05595.1 - 1.6 9.0 6.3 1.3 9.2 1.0 3.1 4 0 0 4 4 2 0 Flagellar FliJ protein FTCD_C PF04961.12 EDO05595.1 - 3.1 7.5 11.4 1.1 9.0 3.8 2.3 1 1 1 2 2 2 0 Formiminotransferase-cyclodeaminase PHM7_cyt PF14703.6 EDO05595.1 - 4.8 7.4 6.8 1.3 9.2 2.5 2.2 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter DUF745 PF05335.13 EDO05595.1 - 5.6 6.7 14.8 0.3 10.8 7.2 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF745) LMP PF04778.12 EDO05595.1 - 7.2 6.5 9.3 7.1 6.5 0.9 2.5 1 1 1 2 2 2 0 LMP repeated region IFT57 PF10498.9 EDO05595.1 - 8.3 5.3 8.6 0.86 8.5 2.0 2.3 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 FH2 PF02181.23 EDO05595.1 - 10 5.2 11.0 0.12 11.5 2.1 2.2 3 0 0 3 3 3 0 Formin Homology 2 Domain F-box-like_2 PF13013.6 EDO05596.1 - 7.4e-09 35.5 1.5 3.5e-05 23.7 0.2 2.2 1 1 1 2 2 2 2 F-box-like domain VESA1_N PF12785.7 EDO05598.1 - 9.3e-22 77.6 18.6 1.9e-17 63.4 13.2 3.6 1 1 1 2 2 2 2 Variant erythrocyte surface antigen-1 CBF_beta PF02312.17 EDO05598.1 - 0.25 11.0 0.0 0.45 10.1 0.0 1.3 1 0 0 1 1 1 0 Core binding factor beta subunit DUF308 PF03729.13 EDO05598.1 - 0.76 10.1 9.7 5.5 7.4 0.4 3.2 3 0 0 3 3 3 0 Short repeat of unknown function (DUF308) VESA1_N PF12785.7 EDO05599.1 - 2.4e-212 705.9 23.7 2.4e-212 705.9 23.7 2.5 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 Baculo_PEP_C PF04513.12 EDO05599.1 - 0.12 12.4 1.2 0.72 9.9 0.1 2.8 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Apolipoprotein PF01442.18 EDO05599.1 - 0.12 12.2 1.4 0.32 10.8 1.4 1.7 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Syndecan PF01034.20 EDO05599.1 - 0.15 12.0 0.3 0.33 10.9 0.3 1.4 1 0 0 1 1 1 0 Syndecan domain DUF4407 PF14362.6 EDO05599.1 - 0.92 8.8 2.0 12 5.1 2.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) HAP1_N PF04849.13 EDO05599.1 - 4.6 6.3 8.2 5.9 6.0 0.4 2.2 2 0 0 2 2 2 0 HAP1 N-terminal conserved region VESA1_N PF12785.7 EDO05600.1 - 3e-215 715.5 18.2 3e-215 715.5 18.2 3.0 3 0 0 3 3 2 1 Variant erythrocyte surface antigen-1 SKA2 PF16740.5 EDO05600.1 - 0.011 15.5 0.3 0.081 12.7 0.0 2.6 2 1 0 2 2 2 0 Spindle and kinetochore-associated protein 2 CdvA PF18822.1 EDO05600.1 - 0.014 15.2 3.1 2.2 8.1 0.0 3.0 2 0 0 2 2 2 0 CdvA-like coiled-coil domain HisKA_3 PF07730.13 EDO05600.1 - 0.027 15.0 0.0 3.2 8.4 0.0 2.9 2 0 0 2 2 2 0 Histidine kinase Apolipoprotein PF01442.18 EDO05600.1 - 0.058 13.3 2.4 0.22 11.4 2.2 2.0 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.12 EDO05600.1 - 0.077 13.0 0.7 0.71 9.9 0.1 2.7 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus COG6 PF06419.11 EDO05600.1 - 0.28 9.4 0.0 0.52 8.5 0.0 1.5 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 Spc7 PF08317.11 EDO05600.1 - 0.57 9.0 4.2 1.1 8.1 2.5 2.2 2 1 1 3 3 3 0 Spc7 kinetochore protein DUF1664 PF07889.12 EDO05600.1 - 0.78 9.8 7.4 7.9 6.5 0.1 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) ApoLp-III PF07464.11 EDO05600.1 - 1.4 9.0 8.6 1.9 8.6 0.1 3.5 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Jnk-SapK_ap_N PF09744.9 EDO05600.1 - 1.7 8.9 4.5 0.62 10.3 0.8 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF4870 PF09685.10 EDO05601.1 - 0.018 15.2 2.2 0.028 14.5 2.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4870) MLANA PF14991.6 EDO05602.1 - 1.1 9.5 3.3 5.7 7.2 0.1 3.2 3 0 0 3 3 3 0 Protein melan-A Orf78 PF06024.12 EDO05602.1 - 1.7 8.9 7.9 0.52 10.6 0.2 3.2 3 0 0 3 3 3 0 Orf78 (ac78) Baculo_11_kDa PF06143.11 EDO05602.1 - 5.5 6.6 10.2 2.6 7.7 0.2 3.3 3 0 0 3 3 3 0 Baculovirus 11 kDa family VESA1_N PF12785.7 EDO05603.1 - 6.5e-12 45.2 2.5 1.9e-07 30.4 0.4 2.1 1 1 1 2 2 2 2 Variant erythrocyte surface antigen-1 F-box-like_2 PF13013.6 EDO05604.1 - 8.6e-05 22.5 0.2 0.00041 20.3 0.1 1.9 1 1 1 2 2 2 2 F-box-like domain UL45 PF05473.12 EDO05605.1 - 0.39 10.3 6.5 11 5.6 0.3 3.4 3 0 0 3 3 3 0 UL45 protein, carbohydrate-binding C-type lectin-like PHO4 PF01384.20 EDO05605.1 - 2.1 7.3 20.0 1.4e+02 1.3 20.0 2.7 1 1 0 1 1 1 0 Phosphate transporter family Cadherin_C_2 PF16492.5 EDO05605.1 - 7.9 7.3 10.0 3.4 8.5 2.2 3.5 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal VESA1_N PF12785.7 EDO05606.1 - 1e-158 529.1 17.5 1e-158 529.1 17.5 2.1 2 0 0 2 2 2 2 Variant erythrocyte surface antigen-1 DUF3886 PF13025.6 EDO05606.1 - 0.1 12.8 2.2 0.26 11.5 2.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3886) LMP PF04778.12 EDO05606.1 - 1.7 8.5 3.9 0.66 9.9 0.5 1.9 2 0 0 2 2 2 0 LMP repeated region DUF1056 PF06341.11 EDO05607.1 - 0.98 9.8 4.4 1.7 9.0 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1056) DUF3522 PF12036.8 EDO05610.1 - 0.0011 19.3 1.3 0.0011 19.3 1.3 4.3 2 2 2 4 4 4 1 Protein of unknown function (DUF3522) RNase_PH PF01138.21 EDO05612.1 - 2.9e-19 69.9 0.0 3.6e-19 69.6 0.0 1.1 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 DUF3157 PF11355.8 EDO05612.1 - 0.018 14.7 0.0 0.026 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3157) Aldo_ket_red PF00248.21 EDO05613.1 - 1.9e-64 217.7 0.0 2.7e-64 217.2 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family NIF PF03031.18 EDO05615.1 - 5.3e-24 84.8 0.3 1.2e-23 83.7 0.3 1.6 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BRCT PF00533.26 EDO05615.1 - 0.011 16.1 0.1 0.026 14.9 0.1 1.6 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Metallophos PF00149.28 EDO05616.1 - 2.1e-30 106.8 0.0 4e-30 105.9 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 EDO05616.1 - 2.9e-16 59.5 0.2 4.1e-15 55.8 0.1 2.6 2 1 0 2 2 2 1 PPP5 TPR repeat region TPR_1 PF00515.28 EDO05616.1 - 1.4e-09 37.3 4.5 4e-05 23.3 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDO05616.1 - 8.6e-08 31.7 3.7 0.023 14.8 0.1 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EDO05616.1 - 0.0001 22.2 1.2 0.27 11.6 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat MIT PF04212.18 EDO05616.1 - 0.00056 19.9 0.1 0.0036 17.3 0.0 2.2 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain TPR_12 PF13424.6 EDO05616.1 - 0.062 13.6 1.0 34 4.8 0.0 3.7 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 EDO05616.1 - 0.12 12.1 0.3 2.7 7.7 0.0 2.6 2 0 0 2 2 2 0 TPR repeat Thioredoxin PF00085.20 EDO05617.1 - 9.5e-06 25.5 0.1 1.4e-05 25.0 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.16 EDO05617.1 - 1.7e-05 23.9 0.0 2.1e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Phosducin Thioredoxin_2 PF13098.6 EDO05617.1 - 0.018 15.5 0.0 0.034 14.6 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain Ribosomal_S8e PF01201.22 EDO05619.1 - 6.3e-54 181.9 0.0 7.5e-54 181.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e VESA1_N PF12785.7 EDO05620.1 - 1.2e-11 44.3 12.0 1.8e-07 30.5 7.4 2.1 1 1 1 2 2 2 2 Variant erythrocyte surface antigen-1 BRX_N PF13713.6 EDO05620.1 - 0.15 11.9 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 Transcription factor BRX N-terminal domain SseC PF04888.12 EDO05621.1 - 1.7 8.2 5.6 3.5 7.1 5.6 1.5 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family CnrY PF17524.2 EDO05621.1 - 5.6 7.3 6.4 10 6.4 0.0 2.7 3 0 0 3 3 3 0 Anti-sigma factor CnrY DUF3638 PF12340.8 EDO05622.1 - 1.3e-22 80.2 0.5 3e-20 72.5 0.1 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF3638) DUF3645 PF12359.8 EDO05622.1 - 8.9e-15 53.8 0.0 2e-14 52.7 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) Vps62 PF06101.11 EDO05622.1 - 2.3e-07 29.5 0.0 4.2e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 LPD11 PF18824.1 EDO05622.1 - 0.044 13.9 0.0 0.14 12.3 0.0 1.8 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 11 Cpn60_TCP1 PF00118.24 EDO05623.1 - 2.9e-168 560.5 0.2 3.3e-168 560.3 0.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family ATP12 PF07542.11 EDO05624.1 - 0.00018 21.6 0.2 0.00038 20.5 0.0 1.7 2 0 0 2 2 2 1 ATP12 chaperone protein SIS PF01380.22 EDO05625.1 - 4.1e-33 114.0 2.1 1.3e-15 57.4 0.1 2.4 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 EDO05625.1 - 2.9e-14 53.4 0.0 6.6e-14 52.3 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EDO05625.1 - 1.6e-08 34.5 0.0 7e-08 32.4 0.0 2.1 1 1 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 EDO05625.1 - 0.0046 15.9 0.0 0.0085 15.0 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_2 PF00310.21 EDO05625.1 - 0.13 11.0 0.0 0.27 9.9 0.0 1.5 1 0 0 1 1 1 0 Glutamine amidotransferases class-II EF-hand_4 PF12763.7 EDO05626.1 - 5.6e-17 61.6 0.3 3.7e-07 30.0 0.1 2.7 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EDO05626.1 - 1.9e-10 39.5 1.4 0.042 13.4 0.1 3.7 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EDO05626.1 - 2.5e-08 34.3 0.9 2.5e-08 34.3 0.9 3.3 3 1 1 4 4 4 1 EF-hand domain pair EF-hand_6 PF13405.6 EDO05626.1 - 8.5e-07 28.4 2.9 0.045 13.7 0.1 4.5 4 0 0 4 4 4 1 EF-hand domain FAD_SOX PF18371.1 EDO05626.1 - 0.00021 21.6 2.3 0.0082 16.5 0.0 2.6 1 1 1 2 2 2 1 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase EF-hand_5 PF13202.6 EDO05626.1 - 0.0011 18.4 0.3 2.4 7.8 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EDO05626.1 - 0.0021 17.9 2.9 1.5 8.7 0.0 3.6 4 0 0 4 4 3 2 EF-hand domain pair Spc7 PF08317.11 EDO05626.1 - 0.0037 16.2 19.8 0.0066 15.4 19.8 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein TSC22 PF01166.18 EDO05626.1 - 0.0083 16.4 1.6 0.0083 16.4 1.6 3.2 2 1 0 3 3 2 1 TSC-22/dip/bun family WD40_alt PF14077.6 EDO05626.1 - 0.0091 15.8 2.6 0.2 11.6 0.2 3.1 3 0 0 3 3 3 1 Alternative WD40 repeat motif CENP-F_leu_zip PF10473.9 EDO05626.1 - 0.027 14.5 23.0 0.025 14.6 5.4 2.7 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HAP1_N PF04849.13 EDO05626.1 - 0.13 11.4 21.8 0.058 12.6 4.0 2.2 1 1 1 2 2 2 0 HAP1 N-terminal conserved region DUF4988 PF16378.5 EDO05626.1 - 0.25 11.0 1.9 8.7 6.0 0.2 2.5 2 1 0 2 2 2 0 Domain of unknown function AAA_23 PF13476.6 EDO05626.1 - 0.59 10.6 5.5 0.93 10.0 5.5 1.4 1 0 0 1 1 1 0 AAA domain FUSC PF04632.12 EDO05626.1 - 1.1 7.8 9.8 1.4 7.3 9.8 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family TMF_TATA_bd PF12325.8 EDO05626.1 - 1.2 9.3 24.7 0.38 11.0 4.5 2.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DivIC PF04977.15 EDO05626.1 - 1.7 8.5 13.2 1.8 8.4 1.0 2.6 1 1 0 2 2 2 0 Septum formation initiator Ly49 PF08391.10 EDO05626.1 - 4.7 7.6 6.7 15 6.0 6.7 1.8 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region DUF4407 PF14362.6 EDO05626.1 - 5.5 6.2 10.4 8.3 5.7 10.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RRM_1 PF00076.22 EDO05627.1 - 3.5e-36 122.9 4.7 4.7e-15 55.2 0.0 6.5 7 0 0 7 7 7 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDO05627.1 - 3.2e-09 36.5 0.2 0.00013 21.8 0.0 4.8 5 1 0 5 5 5 2 Occluded RNA-recognition motif Limkain-b1 PF11608.8 EDO05627.1 - 0.00039 20.4 5.0 0.43 10.7 0.0 5.1 5 1 0 5 5 5 2 Limkain b1 RRM_5 PF13893.6 EDO05627.1 - 0.00095 18.8 0.0 0.71 9.5 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Phage_TAC_13 PF16459.5 EDO05627.1 - 0.0016 18.8 0.0 0.98 9.9 0.0 2.6 2 0 0 2 2 2 2 Phage tail assembly chaperone, TAC RRM_Rrp7 PF17799.1 EDO05627.1 - 0.0031 17.3 3.1 1.4 8.7 0.0 4.2 5 1 0 5 5 5 2 Rrp7 RRM-like N-terminal domain TRAP_alpha PF03896.16 EDO05627.1 - 4.2 6.5 6.7 0.69 9.1 1.8 2.1 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Cgr1 PF03879.14 EDO05628.1 - 3.1e-08 34.0 21.6 3.6e-08 33.7 21.6 1.1 1 0 0 1 1 1 1 Cgr1 family DUF2514 PF10721.9 EDO05628.1 - 0.082 12.9 7.0 0.1 12.7 7.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) Peptidase_Mx1 PF15890.5 EDO05629.1 - 0.087 12.2 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Putative zinc-binding metallo-peptidase DER1 PF04511.15 EDO05630.1 - 1.2e-14 54.7 6.9 1.6e-14 54.3 6.9 1.1 1 0 0 1 1 1 1 Der1-like family Peptidase_M48_N PF16491.5 EDO05631.1 - 2.7e-57 193.6 7.9 5.8e-57 192.5 7.9 1.5 1 0 0 1 1 1 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 EDO05631.1 - 5.7e-35 120.9 0.0 1e-34 120.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M48 DUF1634 PF07843.11 EDO05631.1 - 0.33 11.1 7.9 0.91 9.6 7.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1634) DUF973 PF06157.11 EDO05631.1 - 0.44 9.6 4.1 0.82 8.7 4.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF973) MARVEL PF01284.23 EDO05631.1 - 0.73 9.9 11.8 2.2 8.3 0.0 3.2 3 0 0 3 3 3 0 Membrane-associating domain Proteasome PF00227.26 EDO05632.1 - 4.8e-48 163.2 0.7 5.7e-48 162.9 0.7 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDO05632.1 - 1.5e-13 50.2 0.0 2.6e-13 49.3 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature RL11D PF11088.8 EDO05632.1 - 0.044 14.1 0.3 9.7 6.6 0.1 2.3 2 0 0 2 2 2 0 Glycoprotein encoding membrane proteins RL5A and RL6 Cation_ATPase_C PF00689.21 EDO05634.1 - 0.0062 16.3 7.0 0.0062 16.3 7.0 3.0 2 1 1 3 3 3 1 Cation transporting ATPase, C-terminus DUF2206 PF09971.9 EDO05634.1 - 1.1 8.0 8.5 1.9 7.1 0.0 2.6 1 1 0 2 2 2 0 Predicted membrane protein (DUF2206) SPC25 PF06703.11 EDO05634.1 - 1.4 8.7 5.5 1.3 8.8 3.5 2.1 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) GWT1 PF06423.12 EDO05634.1 - 7.5 6.7 19.7 0.8 9.8 4.3 3.9 1 1 2 3 3 3 0 GWT1 COPI_assoc PF08507.10 EDO05634.1 - 9.7 6.3 19.5 12 6.0 9.4 3.1 3 0 0 3 3 3 0 COPI associated protein VESA1_N PF12785.7 EDO05635.1 - 7.1e-10 38.4 9.9 2.2e-06 27.0 0.3 2.2 1 1 1 2 2 2 2 Variant erythrocyte surface antigen-1 Ad_cyc_g-alpha PF08509.11 EDO05636.1 - 0.063 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Adenylate cyclase G-alpha binding domain GWT1 PF06423.12 EDO05636.1 - 8.4 6.5 11.9 1.1 9.4 1.6 3.3 1 1 1 3 3 3 0 GWT1 DUF1772 PF08592.11 EDO05637.1 - 0.02 15.2 5.5 4 7.8 2.2 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF1772) DUF751 PF05421.11 EDO05637.1 - 0.046 14.4 0.4 0.046 14.4 0.4 4.5 5 0 0 5 5 5 0 Protein of unknown function (DUF751) OPA3 PF07047.12 EDO05638.1 - 1.9e-31 108.4 0.0 2.5e-31 108.1 0.0 1.1 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) GTP_EFTU PF00009.27 EDO05639.1 - 1.7e-07 31.0 1.9 0.01 15.4 0.0 3.3 2 2 1 3 3 3 2 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDO05639.1 - 4.1e-07 30.1 0.6 3.4e-06 27.1 0.1 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDO05639.1 - 3.4e-06 27.1 0.0 8.8e-06 25.7 0.0 1.6 1 1 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 EDO05639.1 - 0.0031 17.6 0.0 0.11 12.5 0.0 2.6 2 0 0 2 2 2 1 Dynamin family PduV-EutP PF10662.9 EDO05639.1 - 0.0098 15.6 0.0 0.12 12.1 0.0 2.3 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Spore_IV_A PF09547.10 EDO05639.1 - 0.032 13.2 0.0 0.049 12.6 0.0 1.2 1 0 0 1 1 1 0 Stage IV sporulation protein A (spore_IV_A) AAA_16 PF13191.6 EDO05639.1 - 0.081 13.3 0.0 0.29 11.5 0.1 1.8 2 0 0 2 2 2 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 EDO05639.1 - 0.14 11.5 0.1 0.36 10.2 0.0 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family DEAD PF00270.29 EDO05640.1 - 4.3e-27 95.0 0.0 7e-27 94.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO05640.1 - 5.1e-23 81.5 0.1 3.1e-22 79.0 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO05640.1 - 0.0078 16.2 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit TPR_19 PF14559.6 EDO05643.1 - 7.9e-16 58.3 10.3 0.00013 22.4 0.0 7.2 8 0 0 8 8 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 EDO05643.1 - 2e-12 46.8 4.1 0.0062 17.3 0.1 8.8 9 1 2 11 11 8 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDO05643.1 - 5.8e-09 35.4 23.1 0.026 14.6 0.1 10.8 12 0 0 12 12 11 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDO05643.1 - 8.4e-09 35.9 0.3 0.00014 22.4 0.0 4.7 3 1 1 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO05643.1 - 0.00087 19.5 12.6 0.062 13.5 0.2 5.5 4 1 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EDO05643.1 - 0.0037 17.8 7.3 0.032 14.9 0.1 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 EDO05643.1 - 0.0055 16.5 1.0 12 5.9 0.0 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 EDO05643.1 - 0.0073 16.6 5.9 13 6.4 0.0 6.0 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 EDO05643.1 - 0.026 14.2 1.9 32 4.3 0.0 4.8 5 0 0 5 5 5 0 TPR repeat TPR_8 PF13181.6 EDO05643.1 - 0.032 14.4 5.5 11 6.5 0.1 5.6 6 0 0 6 6 5 0 Tetratricopeptide repeat Ribosomal_L5 PF00281.19 EDO05643.1 - 0.077 13.3 0.0 0.22 11.9 0.0 1.8 1 0 0 1 1 1 0 Ribosomal protein L5 Cyclin_C PF02984.19 EDO05643.1 - 0.084 13.0 1.8 0.26 11.4 0.0 2.7 3 0 0 3 3 3 0 Cyclin, C-terminal domain TPR_12 PF13424.6 EDO05643.1 - 0.32 11.3 20.2 8.3 6.8 0.3 7.6 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_1 PF00515.28 EDO05643.1 - 0.51 10.2 16.8 16 5.5 0.3 7.1 7 0 0 7 7 7 0 Tetratricopeptide repeat RAP PF08373.10 EDO05644.1 - 0.017 15.2 0.0 0.068 13.3 0.0 2.1 2 0 0 2 2 2 0 RAP domain DUF4853 PF16145.5 EDO05644.1 - 0.14 12.3 0.0 7.4 6.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4853) PP2C PF00481.21 EDO05646.1 - 2.9e-42 145.1 0.0 3.6e-42 144.8 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EDO05646.1 - 7.3e-05 22.5 0.0 0.0006 19.5 0.0 2.0 2 0 0 2 2 2 1 Protein phosphatase 2C SpoIIE PF07228.12 EDO05646.1 - 0.0011 18.9 0.0 0.12 12.3 0.0 2.4 2 1 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) Mig-14 PF07395.11 EDO05646.1 - 0.18 11.2 0.0 0.71 9.2 0.0 1.8 1 1 1 2 2 2 0 Mig-14 ABC1 PF03109.16 EDO05647.1 - 1.3e-28 99.5 0.0 4.8e-28 97.7 0.0 1.9 2 0 0 2 2 2 1 ABC1 family DUF4325 PF14213.6 EDO05647.1 - 0.034 13.8 0.1 0.11 12.2 0.1 1.9 1 0 0 1 1 1 0 STAS-like domain of unknown function (DUF4325) APH PF01636.23 EDO05647.1 - 0.059 13.3 0.0 0.43 10.5 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Ribosomal_L33 PF00471.20 EDO05648.1 - 2.4e-19 69.5 1.9 3.3e-19 69.1 1.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L33 ACBP PF00887.19 EDO05649.1 - 2.5e-28 98.1 1.0 2.8e-28 98.0 1.0 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein AP2 PF00847.20 EDO05650.1 - 4.4e-13 49.2 4.6 7.7e-13 48.5 4.6 1.4 1 0 0 1 1 1 1 AP2 domain JmjC PF02373.22 EDO05651.1 - 2.1e-35 121.6 0.1 4.5e-35 120.5 0.1 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-C5HC2 PF02928.16 EDO05651.1 - 6.5e-08 32.9 14.0 1.5e-07 31.7 14.0 1.7 1 0 0 1 1 1 1 C5HC2 zinc finger JmjN PF02375.17 EDO05651.1 - 0.0038 17.1 0.0 0.01 15.8 0.0 1.8 1 0 0 1 1 1 1 jmjN domain HEAT_EZ PF13513.6 EDO05652.1 - 2.6e-12 46.9 0.6 4e-07 30.4 0.0 5.0 5 0 0 5 5 5 2 HEAT-like repeat IBN_N PF03810.19 EDO05652.1 - 1.2e-07 31.5 0.1 5.5e-07 29.4 0.0 2.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT PF02985.22 EDO05652.1 - 1.1e-06 28.4 1.0 0.014 15.6 0.0 5.0 5 0 0 5 5 5 2 HEAT repeat Arm PF00514.23 EDO05652.1 - 8.3e-05 22.5 0.1 0.014 15.4 0.0 3.8 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 EDO05652.1 - 0.00019 21.8 0.6 1.2 9.6 0.0 5.1 3 2 1 4 4 4 1 HEAT repeats Xpo1 PF08389.12 EDO05652.1 - 0.0054 16.8 0.9 0.68 10.0 0.0 4.0 2 2 1 3 3 3 1 Exportin 1-like protein UME PF08064.13 EDO05652.1 - 0.03 14.2 0.9 2 8.4 0.0 3.9 2 1 1 3 3 3 0 UME (NUC010) domain DRIM PF07539.12 EDO05652.1 - 0.091 11.0 0.4 6.2 5.0 0.0 3.1 2 2 1 3 3 3 0 Down-regulated in metastasis FTR_C PF02741.15 EDO05652.1 - 0.11 12.5 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 FTR, proximal lobe Pribosyltran PF00156.27 EDO05653.1 - 2e-12 46.9 0.1 3.7e-12 46.0 0.1 1.4 2 0 0 2 2 2 1 Phosphoribosyl transferase domain CPT PF07931.12 EDO05653.1 - 0.035 13.9 0.0 0.047 13.5 0.0 1.2 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein PSDC PF12588.8 EDO05654.1 - 0.14 12.1 0.1 1.2 9.1 0.0 2.2 2 0 0 2 2 2 0 Phophatidylserine decarboxylase RIIa PF02197.17 EDO05655.1 - 0.014 15.0 0.6 0.054 13.2 0.0 2.3 2 0 0 2 2 2 0 Regulatory subunit of type II PKA R-subunit DNA_pol_alpha_N PF12254.8 EDO05655.1 - 0.066 13.3 0.3 0.13 12.3 0.0 1.6 2 0 0 2 2 2 0 DNA polymerase alpha subunit p180 N terminal Methyltr_RsmB-F PF01189.17 EDO05656.1 - 2.7e-31 108.8 0.0 1.9e-29 102.7 0.0 2.6 2 1 0 2 2 2 2 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EDO05656.1 - 0.00077 19.6 0.0 0.0014 18.8 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase HECT PF00632.25 EDO05657.1 - 2.1e-66 224.5 0.0 3.5e-66 223.8 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) LSM PF01423.22 EDO05658.1 - 0.0085 15.8 0.1 0.037 13.7 0.0 2.0 2 0 0 2 2 2 1 LSM domain UvrB_inter PF17757.1 EDO05658.1 - 0.025 14.8 0.1 0.045 13.9 0.1 1.5 1 1 0 1 1 1 0 UvrB interaction domain IncF PF17626.2 EDO05659.1 - 0.31 11.4 5.9 0.6 10.5 5.9 1.4 1 0 0 1 1 1 0 Inclusion membrane protein F IMP2_N PF18590.1 EDO05660.1 - 2.3e-25 88.9 0.2 3.7e-25 88.3 0.2 1.3 1 0 0 1 1 1 1 Immune Mapped Protein 2 (IMP2) N-terminal domain B56 PF01603.20 EDO05661.1 - 6.8e-146 486.5 4.2 8.9e-146 486.1 4.2 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) CPDase PF07823.11 EDO05661.1 - 0.15 11.8 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 Cyclic phosphodiesterase-like protein V-SNARE PF05008.15 EDO05662.1 - 0.00044 20.6 4.6 0.00066 20.0 4.6 1.3 1 1 0 1 1 1 1 Vesicle transport v-SNARE protein N-terminus Allexi_40kDa PF05549.11 EDO05662.1 - 0.002 17.7 4.1 0.0024 17.4 4.1 1.0 1 0 0 1 1 1 1 Allexivirus 40kDa protein WEMBL PF05701.11 EDO05662.1 - 0.0075 15.0 3.8 0.0083 14.9 3.8 1.0 1 0 0 1 1 1 1 Weak chloroplast movement under blue light DUF5131 PF07505.11 EDO05662.1 - 0.013 15.0 0.1 0.015 14.7 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF5131) DUF5339 PF17274.2 EDO05662.1 - 0.019 15.8 0.3 0.15 12.9 0.0 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5339) FPP PF05911.11 EDO05662.1 - 0.02 13.1 5.0 0.025 12.8 5.0 1.0 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil BLOC1_2 PF10046.9 EDO05662.1 - 0.036 14.4 4.6 0.43 10.9 0.2 2.2 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 YlqD PF11068.8 EDO05662.1 - 0.062 13.7 4.8 0.039 14.3 3.3 1.4 2 0 0 2 2 1 0 YlqD protein Phage_pRha PF09669.10 EDO05662.1 - 0.067 13.7 1.1 0.12 12.9 1.1 1.6 1 1 0 1 1 1 0 Phage regulatory protein Rha (Phage_pRha) CoA_transf_3 PF02515.17 EDO05662.1 - 0.077 12.1 0.4 0.082 12.0 0.4 1.0 1 0 0 1 1 1 0 CoA-transferase family III Com_YlbF PF06133.11 EDO05662.1 - 0.094 13.3 5.6 0.066 13.8 3.7 1.6 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA Seryl_tRNA_N PF02403.22 EDO05662.1 - 0.1 12.8 6.4 0.58 10.4 0.6 2.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Muted PF14942.6 EDO05662.1 - 0.16 12.3 5.4 0.21 11.9 5.4 1.1 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Fib_alpha PF08702.10 EDO05662.1 - 0.18 12.0 6.1 2 8.6 6.1 2.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Frataxin_Cyay PF01491.16 EDO05662.1 - 0.19 11.8 2.1 2.2 8.4 1.9 2.2 1 1 0 1 1 1 0 Frataxin-like domain TMPIT PF07851.13 EDO05662.1 - 0.24 10.6 2.3 0.29 10.3 2.3 1.1 1 0 0 1 1 1 0 TMPIT-like protein MCU PF04678.13 EDO05662.1 - 0.27 11.3 1.6 0.33 11.0 0.5 1.6 1 1 1 2 2 2 0 Mitochondrial calcium uniporter Spc7 PF08317.11 EDO05662.1 - 0.3 9.9 5.9 0.47 9.3 5.9 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein Fzo_mitofusin PF04799.13 EDO05662.1 - 0.41 10.2 5.1 4.6 6.8 4.4 1.9 1 1 1 2 2 2 0 fzo-like conserved region Csm1_N PF18504.1 EDO05662.1 - 0.86 10.0 7.3 1.4 9.3 1.4 2.5 1 1 1 2 2 2 0 Csm1 N-terminal domain XhlA PF10779.9 EDO05662.1 - 1.2 9.4 8.8 0.81 9.9 0.5 2.7 2 1 1 3 3 3 0 Haemolysin XhlA RRM_1 PF00076.22 EDO05663.1 - 3e-16 59.0 0.0 2.4e-11 43.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WW PF00397.26 EDO05663.1 - 1.3e-09 38.0 3.7 2.6e-09 37.0 3.7 1.5 1 0 0 1 1 1 1 WW domain RNA_bind PF08675.11 EDO05663.1 - 0.052 13.6 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 RNA binding domain Suf PF05843.14 EDO05664.1 - 1.5e-06 28.5 10.1 0.11 12.5 0.9 5.8 5 1 0 5 5 5 2 Suppressor of forked protein (Suf) TPR_8 PF13181.6 EDO05664.1 - 1.8e-05 24.5 3.5 0.066 13.4 0.1 5.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_15 PF13429.6 EDO05664.1 - 0.00038 19.8 0.2 0.06 12.6 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDO05664.1 - 0.001 19.7 8.0 70 4.6 0.0 8.3 9 2 2 11 11 11 0 Tetratricopeptide repeat TPR_12 PF13424.6 EDO05664.1 - 0.0028 17.9 0.2 1.9 8.9 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EDO05664.1 - 0.0084 16.1 0.8 0.0084 16.1 0.8 6.0 4 4 1 6 6 6 1 Mad3/BUB1 homology region 1 TPR_MalT PF17874.1 EDO05664.1 - 0.017 14.5 0.1 3.7 6.8 0.0 2.7 2 0 0 2 2 2 0 MalT-like TPR region TPR_2 PF07719.17 EDO05664.1 - 0.058 13.5 9.1 0.3 11.3 0.1 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF1411 PF07199.11 EDO05665.1 - 8.7e-08 32.0 0.0 0.087 12.5 0.0 3.1 3 0 0 3 3 3 3 Protein of unknown function (DUF1411) CK2S PF15011.6 EDO05666.1 - 0.0088 15.9 0.1 0.08 12.8 0.0 2.6 2 0 0 2 2 2 1 Casein Kinase 2 substrate IFT57 PF10498.9 EDO05666.1 - 0.048 12.6 0.8 0.099 11.6 0.8 1.4 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF948 PF06103.11 EDO05666.1 - 0.076 13.3 1.1 0.27 11.5 0.4 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.12 EDO05666.1 - 0.92 10.0 5.9 10 6.7 0.5 3.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein PNK3P PF08645.11 EDO05667.1 - 1.6e-41 141.7 0.0 2.6e-41 141.0 0.0 1.4 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 EDO05667.1 - 2.1e-10 40.9 0.0 5.4e-05 23.4 0.0 2.8 2 1 1 3 3 3 2 AAA domain KTI12 PF08433.10 EDO05667.1 - 0.00032 20.2 0.9 0.022 14.2 0.2 2.3 1 1 1 2 2 2 1 Chromatin associated protein KTI12 SRPRB PF09439.10 EDO05667.1 - 0.061 12.8 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA PF00004.29 EDO05667.1 - 0.062 13.7 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EDO05667.1 - 0.091 12.8 0.0 0.25 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EDO05667.1 - 0.094 13.0 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EDO05667.1 - 0.11 11.7 0.0 15 4.8 0.0 2.4 1 1 1 2 2 2 0 Zeta toxin AAA_16 PF13191.6 EDO05667.1 - 0.21 12.0 0.0 0.38 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 EDO05667.1 - 0.22 11.0 0.0 0.46 10.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain API5 PF05918.11 EDO05668.1 - 0.0032 16.3 1.1 0.48 9.2 0.0 3.1 3 0 0 3 3 3 2 Apoptosis inhibitory protein 5 (API5) TFCD_C PF12612.8 EDO05668.1 - 0.005 16.7 11.6 17 5.2 0.0 7.0 5 2 1 6 6 6 1 Tubulin folding cofactor D C terminal ParcG PF10274.9 EDO05668.1 - 0.15 12.2 3.1 0.48 10.5 0.1 3.4 4 0 0 4 4 4 0 Parkin co-regulated protein HEAT_2 PF13646.6 EDO05668.1 - 0.23 11.9 8.9 59 4.1 0.0 6.6 7 0 0 7 7 7 0 HEAT repeats STAT_int PF02865.17 EDO05668.1 - 0.29 11.6 1.5 12 6.4 0.0 4.0 4 0 0 4 4 4 0 STAT protein, protein interaction domain Tuberin PF03542.16 EDO05668.1 - 0.4 9.7 9.1 4.6 6.2 0.1 4.1 4 1 0 4 4 4 0 Tuberin DRIM PF07539.12 EDO05668.1 - 1.7 6.8 21.3 0.089 11.1 0.2 5.7 6 1 0 6 6 6 0 Down-regulated in metastasis Xpo1 PF08389.12 EDO05668.1 - 1.8 8.6 13.2 10 6.2 0.0 6.7 8 0 0 8 8 8 0 Exportin 1-like protein COX2 PF00116.20 EDO05669.1 - 0.0014 18.5 0.1 0.0033 17.3 0.1 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, periplasmic domain Use1 PF09753.9 EDO05670.1 - 6.8e-06 26.0 2.4 9.6e-06 25.5 2.4 1.4 1 1 0 1 1 1 1 Membrane fusion protein Use1 Sigma70_ner PF04546.13 EDO05670.1 - 0.2 11.5 3.4 0.22 11.4 1.4 1.8 2 0 0 2 2 2 0 Sigma-70, non-essential region Sec23_trunk PF04811.15 EDO05672.1 - 2.5e-40 138.6 0.0 4e-40 137.9 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EDO05672.1 - 3.5e-22 79.0 0.1 9.2e-22 77.6 0.1 1.8 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EDO05672.1 - 1.7e-14 53.5 4.8 3.3e-14 52.6 4.8 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_helical PF04815.15 EDO05672.1 - 5.5e-14 51.8 0.0 1.6e-13 50.4 0.0 1.8 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Gelsolin PF00626.22 EDO05672.1 - 1.8e-06 27.7 0.0 4.1e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat VWA_2 PF13519.6 EDO05672.1 - 0.003 18.2 0.1 0.027 15.1 0.1 2.5 2 0 0 2 2 2 1 von Willebrand factor type A domain Vps36-NZF-N PF16988.5 EDO05672.1 - 0.0064 15.9 0.1 0.015 14.7 0.1 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-RanBP PF00641.18 EDO05672.1 - 0.88 9.0 5.2 0.083 12.2 0.4 1.8 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others PRMT5 PF05185.16 EDO05673.1 - 1.6e-62 210.4 0.0 3e-62 209.5 0.0 1.4 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 EDO05673.1 - 1.4e-51 174.9 4.4 2.4e-51 174.1 4.4 1.4 1 0 0 1 1 1 1 PRMT5 oligomerisation domain PRMT5_TIM PF17285.2 EDO05673.1 - 6.4e-35 120.6 0.0 1.3e-34 119.6 0.0 1.5 1 0 0 1 1 1 1 PRMT5 TIM barrel domain Met_10 PF02475.16 EDO05673.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein DUF1411 PF07199.11 EDO05674.1 - 0.00022 20.9 0.2 0.44 10.2 0.0 2.2 1 1 0 2 2 2 2 Protein of unknown function (DUF1411) DUF1411 PF07199.11 EDO05675.1 - 7.3e-06 25.8 0.0 2.5e-05 24.0 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1411) Glycolytic PF00274.19 EDO05677.1 - 1.1e-160 534.1 0.0 1.2e-160 534.0 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I Prefoldin PF02996.17 EDO05678.1 - 4.4e-23 81.5 0.8 6.3e-23 81.0 0.8 1.3 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 EDO05678.1 - 0.0056 16.6 1.8 0.12 12.3 0.0 2.3 2 0 0 2 2 2 1 Prefoldin subunit Fib_alpha PF08702.10 EDO05678.1 - 0.0059 16.8 5.4 0.81 9.9 0.2 2.2 2 0 0 2 2 2 2 Fibrinogen alpha/beta chain family DUF1192 PF06698.11 EDO05678.1 - 0.012 15.7 0.2 0.029 14.4 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) SlyX PF04102.12 EDO05678.1 - 0.013 16.1 6.8 0.071 13.7 0.7 2.2 2 0 0 2 2 2 0 SlyX DUF4600 PF15372.6 EDO05678.1 - 0.015 15.7 2.6 0.62 10.5 0.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4600) Cep57_MT_bd PF06657.13 EDO05678.1 - 0.036 14.5 3.4 2.5 8.6 0.1 2.4 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Trimer_CC PF08954.11 EDO05678.1 - 0.12 12.0 3.1 0.96 9.1 1.0 2.3 2 0 0 2 2 2 0 Trimerisation motif COG5 PF10392.9 EDO05678.1 - 0.12 12.5 3.6 0.29 11.3 0.4 2.1 2 0 0 2 2 2 0 Golgi transport complex subunit 5 DUF16 PF01519.16 EDO05678.1 - 0.21 12.1 4.4 7 7.2 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF16 Filament PF00038.21 EDO05678.1 - 0.25 10.9 5.7 1.9 8.0 0.6 2.0 2 0 0 2 2 2 0 Intermediate filament protein BLOC1_2 PF10046.9 EDO05678.1 - 0.26 11.6 5.8 0.88 9.9 0.5 2.5 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF5082 PF16888.5 EDO05678.1 - 0.34 11.2 6.3 0.99 9.7 0.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) ABC_tran_CTD PF16326.5 EDO05678.1 - 0.38 11.0 3.2 4.9 7.5 0.2 2.4 2 0 0 2 2 2 0 ABC transporter C-terminal domain DUF1664 PF07889.12 EDO05678.1 - 0.86 9.7 4.9 3.9 7.5 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) ZapB PF06005.12 EDO05678.1 - 1.4 9.4 7.0 9.1 6.8 0.9 2.3 2 1 0 2 2 2 0 Cell division protein ZapB OB_NTP_bind PF07717.16 EDO05679.1 - 2.3e-11 43.9 0.0 5.8e-11 42.6 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EDO05679.1 - 3.4e-11 43.4 0.0 6.2e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) CtaG_Cox11 PF04442.14 EDO05680.1 - 1.9e-52 177.3 0.1 2.6e-52 176.8 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 Chordopox_A33R PF05966.12 EDO05681.1 - 0.0022 17.3 2.5 0.0035 16.7 2.5 1.3 1 0 0 1 1 1 1 Chordopoxvirus A33R protein Longin PF13774.6 EDO05681.1 - 0.01 15.9 0.0 0.02 14.9 0.0 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain DUF2615 PF11027.8 EDO05681.1 - 0.032 14.4 0.0 0.063 13.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) DUF4408 PF14364.6 EDO05681.1 - 7.5 6.4 7.5 15 5.4 7.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4408) Kin17_mid PF10357.9 EDO05683.1 - 2e-43 147.3 0.8 3.4e-43 146.6 0.8 1.4 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein KN17_SH3 PF18131.1 EDO05683.1 - 3.9e-05 23.7 0.2 0.00014 21.9 0.1 2.0 2 0 0 2 2 2 1 KN17 SH3-like C-terminal domain zf-met PF12874.7 EDO05683.1 - 0.011 16.1 3.4 0.034 14.5 3.4 1.9 1 0 0 1 1 1 0 Zinc-finger of C2H2 type KOW PF00467.29 EDO05683.1 - 0.013 15.4 0.1 0.075 13.0 0.0 2.4 2 0 0 2 2 2 0 KOW motif zf-C2H2_jaz PF12171.8 EDO05683.1 - 0.023 15.0 5.0 0.055 13.8 5.0 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding DUF3593 PF12159.8 EDO05683.1 - 0.16 12.0 0.0 0.25 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3593) zf-C2H2_2 PF12756.7 EDO05683.1 - 3.9 7.9 9.9 3.1 8.2 5.6 2.3 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) ISP1_C PF18161.1 EDO05684.1 - 1.2e-26 92.7 1.0 2e-26 92.0 1.0 1.3 1 0 0 1 1 1 1 ISP1 C-terminal ISP3_C PF18045.1 EDO05684.1 - 1.5e-25 89.2 1.6 2.5e-25 88.5 1.6 1.3 1 0 0 1 1 1 1 ISP3 C-terminal Ribosomal_L22 PF00237.19 EDO05684.1 - 1.2e-06 28.7 0.0 2.8e-06 27.5 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e MgtE_N PF03448.17 EDO05684.1 - 0.019 15.5 0.0 0.037 14.6 0.0 1.4 1 0 0 1 1 1 0 MgtE intracellular N domain Phage_RpbA PF10789.9 EDO05684.1 - 0.048 13.7 1.0 4.8 7.3 0.1 2.5 2 0 0 2 2 2 0 Phage RNA polymerase binding, RpbA TPR_8 PF13181.6 EDO05685.1 - 0.0002 21.3 0.3 0.19 12.1 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDO05685.1 - 0.0062 17.3 0.0 7.8 7.6 0.0 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDO05685.1 - 0.011 16.0 0.2 0.99 9.7 0.0 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EDO05685.1 - 0.019 15.5 0.8 9.4 6.8 0.0 3.4 3 2 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EDO05685.1 - 0.066 13.1 0.3 7.1 6.6 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat L27 PF02828.16 EDO05685.1 - 0.13 12.1 0.8 0.62 9.9 0.2 2.1 2 0 0 2 2 2 0 L27 domain Clathrin PF00637.20 EDO05685.1 - 0.43 10.4 5.7 3.7 7.4 0.2 3.4 3 1 0 3 3 3 0 Region in Clathrin and VPS SPOC PF07744.13 EDO05686.1 - 3.9e-10 39.8 0.0 7.8e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 SPOC domain RRM_1 PF00076.22 EDO05686.1 - 5.1e-06 26.2 0.0 0.0012 18.6 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PAC4 PF16093.5 EDO05688.1 - 7.2e-13 48.5 0.0 8.8e-13 48.3 0.0 1.1 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 FOXO-TAD PF16676.5 EDO05688.1 - 0.028 14.8 0.1 0.069 13.6 0.1 1.8 1 0 0 1 1 1 0 Transactivation domain of FOXO protein family TPK_catalytic PF04263.16 EDO05688.1 - 0.069 13.2 0.0 0.074 13.1 0.0 1.2 1 0 0 1 1 1 0 Thiamin pyrophosphokinase, catalytic domain DUF4434 PF14488.6 EDO05688.1 - 0.12 12.4 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4434) Methyltransf_5 PF01795.19 EDO05689.1 - 1.7e-79 267.5 0.1 2.5e-78 263.7 0.1 2.0 1 1 0 1 1 1 1 MraW methylase family Methyltr_RsmB-F PF01189.17 EDO05689.1 - 0.07 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Rotamase PF00639.21 EDO05690.1 - 2.4e-20 73.3 0.0 3.3e-20 72.8 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 EDO05690.1 - 9.2e-17 61.6 0.0 1.5e-16 61.0 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 EDO05690.1 - 5e-05 24.1 0.0 6e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain TAP42 PF04177.12 EDO05691.1 - 2.2e-48 165.0 1.2 2.8e-48 164.7 1.2 1.1 1 0 0 1 1 1 1 TAP42-like family Focal_AT PF03623.13 EDO05691.1 - 0.057 13.4 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 Focal adhesion targeting region Rhabdo_ncap PF00945.18 EDO05691.1 - 0.25 10.2 1.3 0.4 9.5 1.3 1.2 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein Lactamase_B_2 PF12706.7 EDO05692.1 - 2.4e-06 27.2 0.0 0.00057 19.5 0.0 2.4 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EDO05692.1 - 7.1e-06 26.2 0.0 1.4e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily ERAP1_C PF11838.8 EDO05692.1 - 0.1 12.1 0.0 0.27 10.8 0.0 1.6 1 0 0 1 1 1 0 ERAP1-like C-terminal domain Glycos_transf_4 PF00953.21 EDO05693.1 - 1.2e-34 119.6 13.9 2.4e-34 118.6 13.9 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 4 AMP-binding PF00501.28 EDO05694.1 - 2.7e-82 276.6 0.0 3.5e-82 276.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDO05694.1 - 3.4e-06 27.9 0.0 1.3e-05 26.1 0.0 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain SMC_N PF02463.19 EDO05695.1 - 5.2e-11 42.4 0.0 5.8e-11 42.3 0.0 1.0 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EDO05695.1 - 2.3e-10 41.3 0.0 2.6e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EDO05695.1 - 0.024 14.4 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_15 PF13175.6 EDO05695.1 - 0.026 14.3 0.0 0.026 14.3 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain SbcCD_C PF13558.6 EDO05696.1 - 0.00088 19.5 0.2 0.067 13.4 0.0 2.7 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Spc7 PF08317.11 EDO05696.1 - 0.0025 16.8 85.1 0.0032 16.4 19.4 6.3 2 2 4 7 7 7 6 Spc7 kinetochore protein DUF4201 PF13870.6 EDO05696.1 - 0.0041 16.9 8.0 0.0041 16.9 8.0 6.3 3 3 2 5 5 5 1 Domain of unknown function (DUF4201) RPW8 PF05659.11 EDO05696.1 - 0.01 15.5 2.1 0.01 15.5 2.1 5.0 2 2 1 4 4 4 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 SlyX PF04102.12 EDO05696.1 - 0.023 15.3 2.3 0.023 15.3 2.3 6.8 6 2 2 8 8 8 0 SlyX FAA_hydro_N_2 PF18288.1 EDO05696.1 - 0.12 12.8 5.4 41 4.7 0.0 5.2 4 1 0 4 4 4 0 Fumarylacetoacetase N-terminal domain 2 AAA_13 PF13166.6 EDO05696.1 - 0.15 10.7 71.4 0.0099 14.6 20.3 3.7 2 2 1 4 4 4 0 AAA domain SMC_N PF02463.19 EDO05696.1 - 0.23 10.9 28.8 0.024 14.1 23.7 1.8 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain DUF1722 PF08349.11 EDO05696.1 - 0.97 9.7 18.2 0.55 10.5 1.4 4.3 3 1 1 4 4 4 0 Protein of unknown function (DUF1722) MscS_porin PF12795.7 EDO05696.1 - 2.4 7.6 56.8 0.0087 15.6 14.5 4.6 3 1 2 5 5 5 0 Mechanosensitive ion channel porin domain Filament PF00038.21 EDO05696.1 - 5.8 6.4 79.6 0.35 10.4 33.8 5.5 3 2 2 5 5 5 0 Intermediate filament protein DUF948 PF06103.11 EDO05696.1 - 7.8 6.8 29.5 0.66 10.3 0.2 6.4 5 1 1 6 6 6 0 Bacterial protein of unknown function (DUF948) Methyltransf_32 PF13679.6 EDO05697.1 - 0.15 12.1 0.0 0.17 11.9 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain Wyosine_form PF08608.12 EDO05698.1 - 1.6e-25 89.3 0.1 3.6e-25 88.1 0.1 1.7 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.21 EDO05698.1 - 9.5e-20 71.6 0.0 2e-19 70.6 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Hydrolase_6 PF13344.6 EDO05698.1 - 0.043 13.9 0.0 0.15 12.2 0.0 1.9 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDO05698.1 - 0.21 11.8 0.0 0.35 11.1 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase RNA_pol_A_bac PF01000.26 EDO05699.1 - 1.1e-09 38.6 0.0 2.6e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EDO05699.1 - 0.00068 19.0 0.0 0.0014 18.1 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain HHH_5 PF14520.6 EDO05699.1 - 0.089 13.4 0.0 0.21 12.2 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix domain RNA_pol_A_CTD PF03118.15 EDO05699.1 - 0.1 12.3 0.0 0.27 11.0 0.0 1.6 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain DUF1411 PF07199.11 EDO05700.1 - 2.7e-09 37.0 0.1 1.5e-05 24.7 0.1 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF1411) zf-C2H2_assoc2 PF16624.5 EDO05701.1 - 0.14 13.2 2.5 0.11 13.5 1.0 1.5 2 0 0 2 2 2 0 Unstructured region upstream of a zinc-finger ThiF PF00899.21 EDO05702.1 - 3.5e-62 209.9 0.0 5.2e-62 209.4 0.0 1.2 1 0 0 1 1 1 1 ThiF family UBA_e1_thiolCys PF10585.9 EDO05702.1 - 2.4e-11 44.1 0.1 1e-06 28.9 0.0 2.8 1 1 0 2 2 2 2 Ubiquitin-activating enzyme active site UAE_UbL PF14732.6 EDO05702.1 - 7.9e-07 29.6 0.2 5.4e-06 26.9 0.0 2.4 3 0 0 3 3 3 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain NAD_binding_7 PF13241.6 EDO05702.1 - 0.0068 16.8 0.1 0.022 15.2 0.1 1.8 1 0 0 1 1 1 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 EDO05702.1 - 0.026 14.6 0.3 0.11 12.6 0.1 2.1 1 1 1 2 2 2 0 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 EDO05702.1 - 0.17 12.5 0.2 0.45 11.1 0.2 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EDO05702.1 - 0.18 11.0 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Myb_DNA-binding PF00249.31 EDO05703.1 - 2e-06 27.9 0.3 8.2e-06 25.9 0.0 2.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain ZZ PF00569.17 EDO05703.1 - 0.00016 21.4 11.0 0.00041 20.1 11.0 1.7 1 0 0 1 1 1 1 Zinc finger, ZZ type Thioredoxin PF00085.20 EDO05704.1 - 2.8e-17 62.6 0.0 9.1e-17 60.9 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_6 PF13848.6 EDO05704.1 - 1.3e-06 28.5 6.2 0.0021 18.0 2.0 3.9 2 1 3 5 5 5 2 Thioredoxin-like domain Glutaredoxin PF00462.24 EDO05704.1 - 1.8e-05 24.9 0.0 4.2e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_2 PF13098.6 EDO05704.1 - 0.0023 18.3 0.1 0.011 16.1 0.1 2.2 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 EDO05704.1 - 0.033 14.4 0.0 0.083 13.1 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin-like TraF PF13728.6 EDO05704.1 - 0.19 11.5 0.0 0.33 10.7 0.0 1.3 1 0 0 1 1 1 0 F plasmid transfer operon protein Suf PF05843.14 EDO05705.1 - 1.1e-07 32.1 5.7 0.0001 22.4 0.0 3.8 4 0 0 4 4 4 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 EDO05705.1 - 1.2e-06 28.8 0.0 0.0053 17.5 0.0 4.3 2 1 1 3 3 3 2 Tetratricopeptide repeat Flp_N PF03930.14 EDO05705.1 - 0.032 14.2 0.4 0.069 13.1 0.4 1.5 1 0 0 1 1 1 0 Recombinase Flp protein N-terminus DUF760 PF05542.11 EDO05706.1 - 2.1e-31 108.1 0.5 2.7e-15 56.5 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF760) DUF1720 PF08226.11 EDO05706.1 - 0.017 15.5 1.3 0.055 13.9 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1720) MCR_beta PF02241.18 EDO05706.1 - 0.092 12.3 0.1 0.16 11.5 0.1 1.4 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, C-terminal domain ArfGap PF01412.18 EDO05709.1 - 3.1e-37 127.2 0.0 4.9e-37 126.6 0.0 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Macro_2 PF14519.6 EDO05709.1 - 0.011 15.1 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 Macro-like domain IMCp PF12314.8 EDO05710.1 - 2e-19 69.7 53.4 2.2e-12 47.1 26.7 2.3 1 1 1 2 2 2 2 Inner membrane complex protein Sof1 PF04158.14 EDO05710.1 - 6.8 7.0 10.2 4.8 7.5 1.9 2.6 1 1 1 2 2 2 0 Sof1-like domain SpoU_methylase PF00588.19 EDO05711.1 - 4.6e-07 30.1 0.0 8.2e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 SpoU rRNA Methylase family WD40 PF00400.32 EDO05712.1 - 5e-13 49.3 18.2 0.0052 17.6 0.8 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat WD40_like PF17005.5 EDO05712.1 - 0.022 14.1 0.0 2.5 7.4 0.0 2.1 2 0 0 2 2 2 0 WD40-like domain CAF1C_H4-bd PF12265.8 EDO05713.1 - 1.4e-12 47.6 0.0 3.2e-12 46.5 0.0 1.6 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EDO05713.1 - 4.3e-08 33.7 7.8 0.22 12.4 0.0 6.3 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO05713.1 - 0.039 14.2 0.0 2.1 8.7 0.0 3.0 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain DUF4841 PF16129.5 EDO05715.1 - 0.2 11.9 0.6 2 8.8 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4841) tRNA-synt_His PF13393.6 EDO05716.1 - 6.5e-44 150.5 0.0 9.8e-44 149.9 0.0 1.3 1 0 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 EDO05716.1 - 2.6e-08 33.9 0.1 8.1e-08 32.3 0.0 1.8 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2 PF00152.20 EDO05716.1 - 0.00011 21.5 0.6 0.0039 16.3 0.0 2.9 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 EDO05716.1 - 0.0085 15.6 0.0 0.017 14.6 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) HGTP_anticodon2 PF12745.7 EDO05716.1 - 0.054 13.0 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs DEAD PF00270.29 EDO05717.1 - 2.3e-33 115.4 0.2 5.3e-33 114.2 0.2 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO05717.1 - 4.6e-19 68.8 4.6 6.7e-19 68.3 1.4 2.8 3 1 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO05717.1 - 1.1e-05 25.5 0.6 3.5e-05 23.9 0.0 2.1 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDO05717.1 - 0.00011 22.5 2.1 0.0082 16.4 0.6 3.3 2 2 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EDO05717.1 - 0.031 14.6 0.1 0.087 13.2 0.0 1.9 2 1 0 2 2 2 0 AAA domain FSH1 PF03959.13 EDO05718.1 - 3.1e-31 108.7 0.0 4.4e-31 108.2 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.18 EDO05718.1 - 0.013 15.1 0.0 0.021 14.4 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family Lipase_3 PF01764.25 EDO05718.1 - 0.015 15.2 0.0 0.031 14.1 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Hydrolase_4 PF12146.8 EDO05718.1 - 0.028 13.7 0.1 1.4 8.1 0.0 2.6 2 1 1 3 3 3 0 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 EDO05718.1 - 0.13 12.1 0.0 0.39 10.5 0.0 1.8 1 1 1 2 2 2 0 alpha/beta hydrolase fold DAP3 PF10236.9 EDO05719.1 - 2e-21 76.5 0.0 9.6e-13 48.0 0.0 2.1 2 0 0 2 2 2 2 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 EDO05719.1 - 0.00088 19.7 0.0 0.0028 18.1 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 EDO05719.1 - 0.024 14.4 0.0 0.045 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EDO05719.1 - 0.057 13.7 0.0 0.44 10.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EDO05719.1 - 0.14 12.2 0.2 6.6 6.8 0.0 2.6 3 0 0 3 3 3 0 AAA domain Pkinase PF00069.25 EDO05720.1 - 9.7e-43 146.4 0.0 1.2e-42 146.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO05720.1 - 6.6e-21 74.8 0.0 1.2e-20 74.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EDO05720.1 - 0.021 14.4 1.4 0.093 12.3 0.0 2.4 2 0 0 2 2 2 0 RIO1 family Rdx PF10262.9 EDO05721.1 - 0.088 13.0 0.0 0.48 10.6 0.0 2.2 2 1 0 2 2 2 0 Rdx family Peptidase_M16 PF00675.20 EDO05723.1 - 7.4e-45 152.6 0.0 1.5e-44 151.6 0.0 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EDO05723.1 - 5e-27 95.1 0.0 2.8e-26 92.7 0.0 2.1 2 0 0 2 2 2 1 Peptidase M16 inactive domain PEGA PF08308.11 EDO05723.1 - 0.14 12.1 0.0 0.48 10.3 0.0 1.8 2 0 0 2 2 2 0 PEGA domain GCP_N_terminal PF17681.1 EDO05724.1 - 5.2e-33 115.0 0.6 5.7e-32 111.6 0.2 2.4 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal TPR_MLP1_2 PF07926.12 EDO05725.1 - 8.8e-05 22.6 21.6 0.00018 21.5 1.8 4.1 4 0 0 4 4 4 1 TPR/MLP1/MLP2-like protein JIP_LZII PF16471.5 EDO05725.1 - 0.037 14.2 0.5 0.037 14.2 0.5 4.8 4 2 1 6 6 5 0 JNK-interacting protein leucine zipper II Csm1_N PF18504.1 EDO05725.1 - 0.045 14.1 0.5 0.045 14.1 0.5 4.9 3 2 3 6 6 6 0 Csm1 N-terminal domain ATG16 PF08614.11 EDO05725.1 - 0.087 13.0 29.1 0.11 12.7 6.2 3.8 2 2 1 3 3 3 0 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.9 EDO05725.1 - 0.088 12.8 34.9 0.023 14.7 6.4 5.0 2 2 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MAD PF05557.13 EDO05725.1 - 0.17 10.2 20.7 0.29 9.5 7.8 2.6 2 1 0 2 2 2 0 Mitotic checkpoint protein RILP PF11461.8 EDO05725.1 - 0.2 11.9 4.9 0.58 10.4 0.2 3.3 1 1 2 3 3 3 0 Rab interacting lysosomal protein UPF0242 PF06785.11 EDO05725.1 - 0.41 10.7 19.3 1.6 8.8 4.6 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Phage_GP20 PF06810.11 EDO05725.1 - 0.69 9.7 12.3 1.7 8.4 0.3 3.2 3 1 0 3 3 3 0 Phage minor structural protein GP20 Golgin_A5 PF09787.9 EDO05725.1 - 0.84 9.0 23.7 0.053 13.0 6.3 2.8 2 1 1 3 3 3 0 Golgin subfamily A member 5 DUF724 PF05266.14 EDO05725.1 - 0.95 9.3 14.6 1.6 8.5 0.9 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF724) DUF4472 PF14739.6 EDO05725.1 - 1.3 9.8 16.8 0.39 11.5 1.7 4.2 3 2 2 5 5 4 0 Domain of unknown function (DUF4472) ABC_tran_CTD PF16326.5 EDO05725.1 - 1.8 8.8 14.2 1.6 9.0 0.2 4.0 4 0 0 4 4 4 0 ABC transporter C-terminal domain Prefoldin_2 PF01920.20 EDO05725.1 - 4.1 7.4 20.1 0.21 11.5 2.3 4.3 2 2 2 4 4 4 0 Prefoldin subunit Jnk-SapK_ap_N PF09744.9 EDO05725.1 - 5.1 7.3 24.9 7.6 6.7 9.3 2.8 2 2 0 2 2 2 0 JNK_SAPK-associated protein-1 GAS PF13851.6 EDO05725.1 - 6.3 6.1 25.3 0.91 8.8 5.6 3.3 2 2 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF3450 PF11932.8 EDO05725.1 - 7.1 5.9 16.4 0.83 8.9 2.0 3.8 3 1 0 3 3 3 0 Protein of unknown function (DUF3450) SlyX PF04102.12 EDO05725.1 - 8.3 7.1 13.6 41 4.9 2.1 4.9 2 2 3 5 5 5 0 SlyX NB-ARC PF00931.22 EDO05726.1 - 0.029 13.6 0.0 0.034 13.3 0.0 1.0 1 0 0 1 1 1 0 NB-ARC domain Helicase_C_2 PF13307.6 EDO05727.1 - 1e-41 142.9 0.0 3.7e-41 141.2 0.0 1.9 2 0 0 2 2 2 1 Helicase C-terminal domain HBB PF06777.11 EDO05727.1 - 5.4e-30 104.5 0.2 2.7e-24 85.9 0.0 2.4 2 0 0 2 2 2 2 Helical and beta-bridge domain DEAD_2 PF06733.15 EDO05727.1 - 7.9e-23 81.0 0.8 7.5e-13 48.5 0.0 3.3 2 1 0 2 2 2 2 DEAD_2 ResIII PF04851.15 EDO05727.1 - 2.6e-08 34.0 0.0 5.1e-05 23.3 0.0 2.3 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.29 EDO05727.1 - 0.0091 15.8 0.2 0.091 12.5 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase CytadhesinP1 PF12378.8 EDO05727.1 - 0.075 13.2 0.1 0.2 11.9 0.1 1.7 1 0 0 1 1 1 0 Trypsin-sensitive surface-exposed protein UBX PF00789.20 EDO05728.1 - 1.4e-13 50.9 0.0 2.9e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 UBX domain MORN PF02493.20 EDO05729.1 - 1e-80 261.0 97.0 8.1e-08 31.7 4.2 14.2 14 0 0 14 14 14 14 MORN repeat Peptidase_S55 PF05580.12 EDO05729.1 - 0.45 10.4 10.3 2 8.3 0.1 5.0 4 2 2 6 6 6 0 SpoIVB peptidase S55 Mpp10 PF04006.12 EDO05730.1 - 2.1e-33 115.7 64.7 9.2e-33 113.6 64.7 2.1 1 1 0 1 1 1 1 Mpp10 protein PIN_12 PF16289.5 EDO05730.1 - 2 8.9 12.1 0.084 13.4 2.2 2.8 1 1 1 2 2 2 0 PIN domain tRNA-synt_2b PF00587.25 EDO05731.1 - 9.5e-27 94.1 0.0 1.6e-26 93.4 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EDO05731.1 - 2.5e-06 27.7 0.4 5.1e-06 26.7 0.4 1.5 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain FliD_C PF07195.12 EDO05731.1 - 0.031 13.7 0.7 0.06 12.8 0.7 1.4 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus LXG PF04740.12 EDO05731.1 - 0.083 12.6 0.5 0.18 11.5 0.5 1.5 1 0 0 1 1 1 0 LXG domain of WXG superfamily DivIC PF04977.15 EDO05731.1 - 0.2 11.4 1.5 3.5 7.5 0.0 2.4 2 0 0 2 2 2 0 Septum formation initiator Phage_holin_3_5 PF16085.5 EDO05732.1 - 0.15 12.2 1.6 0.2 11.8 1.6 1.2 1 0 0 1 1 1 0 Bacteriophage holin Hol, superfamily III SRP19 PF01922.17 EDO05733.1 - 1.2e-24 87.0 0.0 1.8e-24 86.5 0.0 1.2 1 0 0 1 1 1 1 SRP19 protein MACPF PF01823.19 EDO05734.1 - 4.7e-46 157.5 1.8 4.7e-46 157.5 1.8 1.9 2 0 0 2 2 2 1 MAC/Perforin domain Gemini_mov PF01708.16 EDO05735.1 - 3.9 7.3 11.6 7.9 6.3 1.5 2.8 2 0 0 2 2 2 0 Geminivirus putative movement protein ProRS-C_1 PF09180.11 EDO05736.1 - 5.2e-27 93.9 0.2 1.3e-24 86.2 0.0 2.7 2 0 0 2 2 2 2 Prolyl-tRNA synthetase, C-terminal tRNA_edit PF04073.15 EDO05736.1 - 1e-22 80.5 0.0 1.9e-22 79.6 0.0 1.4 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain tRNA-synt_2b PF00587.25 EDO05736.1 - 5.4e-20 72.1 0.0 1.5e-19 70.6 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EDO05736.1 - 2.8e-17 62.7 0.2 1.2e-16 60.6 0.0 2.3 2 0 0 2 2 2 1 Anticodon binding domain Fucokinase PF07959.12 EDO05737.1 - 2.1e-05 23.6 0.3 2.1e-05 23.6 0.3 2.2 3 0 0 3 3 3 1 L-fucokinase Hexapep PF00132.24 EDO05737.1 - 0.00032 20.3 11.3 0.0057 16.3 5.2 2.9 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.23 EDO05737.1 - 0.0053 16.4 0.1 0.02 14.5 0.0 1.9 2 0 0 2 2 2 1 Nucleotidyl transferase DUF4954 PF16314.5 EDO05737.1 - 0.01 14.0 0.6 0.017 13.3 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) W2 PF02020.18 EDO05737.1 - 0.017 15.3 2.7 0.018 15.2 0.6 2.3 3 0 0 3 3 3 0 eIF4-gamma/eIF5/eIF2-epsilon Pox_RNA_Pol_19 PF05320.12 EDO05737.1 - 0.077 13.0 2.5 0.17 11.9 2.5 1.5 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit tRNA-synt_His PF13393.6 EDO05737.1 - 0.11 11.8 0.5 0.19 10.9 0.5 1.4 1 0 0 1 1 1 0 Histidyl-tRNA synthetase FGF-BP1 PF06473.12 EDO05738.1 - 0.041 13.7 0.5 0.046 13.6 0.5 1.1 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) Sec23_helical PF04815.15 EDO05738.1 - 0.12 12.2 0.2 0.25 11.2 0.0 1.9 2 1 0 2 2 2 0 Sec23/Sec24 helical domain CHCH PF06747.13 EDO05738.1 - 1.8 8.8 5.8 16 5.7 0.7 2.5 2 0 0 2 2 2 0 CHCH domain Phosphodiest PF01663.22 EDO05739.1 - 0.002 17.8 0.1 0.0038 16.9 0.0 1.5 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 EDO05739.1 - 0.021 14.2 0.0 0.065 12.6 0.0 1.7 2 0 0 2 2 2 0 Metalloenzyme superfamily Cornichon PF03311.14 EDO05739.1 - 1.1 9.5 8.5 1.3 9.4 1.2 2.9 2 0 0 2 2 2 0 Cornichon protein Prenyltrans PF00432.21 EDO05741.1 - 1.1e-15 57.1 2.6 0.00091 18.9 0.0 5.1 5 0 0 5 5 5 4 Prenyltransferase and squalene oxidase repeat Phage_holin_3_5 PF16085.5 EDO05741.1 - 0.11 12.7 0.1 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 Bacteriophage holin Hol, superfamily III Fer2 PF00111.27 EDO05743.1 - 7.8e-06 25.8 4.0 5.1e-05 23.2 4.0 2.0 1 1 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain MCR PF18509.1 EDO05743.1 - 1.1 8.9 4.9 0.73 9.5 2.6 1.9 1 1 0 1 1 1 0 Magnetochrome domain Tim17 PF02466.19 EDO05745.1 - 0.0011 19.3 1.6 0.0091 16.4 0.1 2.4 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family PHO4 PF01384.20 EDO05745.1 - 2.5 7.0 10.5 42 3.0 10.7 2.0 1 1 1 2 2 2 0 Phosphate transporter family Polysacc_synt_C PF14667.6 EDO05745.1 - 3.7 7.6 23.2 2.2 8.3 10.7 3.0 1 1 1 2 2 2 0 Polysaccharide biosynthesis C-terminal domain VESA1_N PF12785.7 EDO05746.1 - 1.6e-27 96.6 6.3 5.6e-27 94.8 2.1 3.6 3 1 1 4 4 4 2 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO05747.1 - 4e-217 721.6 24.8 4e-217 721.6 24.8 2.4 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 IL13 PF03487.13 EDO05747.1 - 0.0088 15.8 0.1 0.12 12.2 0.0 2.5 2 0 0 2 2 2 1 Interleukin-13 DDE_Tnp_1_assoc PF13808.6 EDO05747.1 - 0.17 11.9 0.0 3.4 7.7 0.0 2.7 2 0 0 2 2 2 0 DDE_Tnp_1-associated DUF2956 PF11169.8 EDO05748.1 - 0.034 14.3 0.1 0.049 13.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) TAFH PF07531.14 EDO05748.1 - 0.093 12.8 0.6 0.14 12.2 0.6 1.2 1 0 0 1 1 1 0 NHR1 homology to TAF DNA_ligase_A_M PF01068.21 EDO05749.1 - 7.6e-61 205.3 0.8 1.2e-60 204.7 0.1 1.7 2 0 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EDO05749.1 - 5.3e-34 118.0 0.1 1.3e-33 116.7 0.1 1.7 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EDO05749.1 - 3.1e-25 88.6 0.0 6.6e-25 87.6 0.0 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 EDO05749.1 - 6.9e-05 23.2 0.0 0.00012 22.4 0.0 1.4 1 0 0 1 1 1 1 RNA ligase DUF5644 PF18712.1 EDO05749.1 - 0.025 14.6 0.0 0.86 9.6 0.0 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5644) DNA_ligase_OB_2 PF14743.6 EDO05749.1 - 0.13 12.3 0.1 3.8 7.6 0.0 3.0 3 0 0 3 3 3 0 DNA ligase OB-like domain PUB PF09409.10 EDO05750.1 - 2.8e-08 33.6 0.0 5.3e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 PUB domain Acyltransferase PF01553.21 EDO05751.1 - 4.7e-15 55.4 0.0 8.3e-15 54.6 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase SET PF00856.28 EDO05752.1 - 3.1e-13 50.5 1.7 2e-11 44.6 1.7 2.7 1 1 0 1 1 1 1 SET domain SAF PF08666.12 EDO05752.1 - 0.19 12.4 0.0 45 4.8 0.0 3.0 3 0 0 3 3 3 0 SAF domain Pom PF17251.2 EDO05755.1 - 0.0018 17.7 0.1 0.0032 16.8 0.1 1.3 1 0 0 1 1 1 1 Protochlamydia outer membrane protein TFIIE_beta PF02186.15 EDO05756.1 - 0.0022 18.2 0.2 0.0076 16.5 0.1 2.0 2 0 0 2 2 2 1 TFIIE beta subunit core domain FGF-BP1 PF06473.12 EDO05756.1 - 0.015 15.2 0.1 0.022 14.6 0.1 1.2 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) G6PD_C PF02781.16 EDO05757.1 - 2.4e-53 181.2 0.0 3.9e-53 180.5 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain Glucosamine_iso PF01182.20 EDO05757.1 - 1.1e-40 139.9 0.0 1.7e-40 139.3 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase G6PD_N PF00479.22 EDO05757.1 - 8.1e-39 134.1 0.0 1.7e-38 133.0 0.0 1.5 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain DUF4134 PF13572.6 EDO05758.1 - 0.01 16.1 0.3 0.013 15.7 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4134) DUF3995 PF13160.6 EDO05758.1 - 0.035 14.4 0.1 0.039 14.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3995) DUF410 PF04190.13 EDO05759.1 - 1.8e-18 67.3 0.0 2.2e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) DUF4479 PF14794.6 EDO05759.1 - 0.0076 16.1 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4479) BRCA-2_OB3 PF09104.10 EDO05759.1 - 0.052 13.2 0.0 0.096 12.3 0.0 1.3 1 0 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 SNAP PF14938.6 EDO05759.1 - 0.065 12.7 0.0 0.094 12.1 0.0 1.4 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP Beta-Casp PF10996.8 EDO05760.1 - 1.1e-27 96.5 0.0 2.5e-27 95.3 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 EDO05760.1 - 2.2e-18 65.9 0.0 4.6e-18 64.9 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 EDO05760.1 - 1.6e-15 57.6 0.0 6e-15 55.8 0.0 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily CPSF73-100_C PF11718.8 EDO05760.1 - 1.1e-14 54.6 0.1 1.8e-14 53.8 0.1 1.3 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Lactamase_B_6 PF16661.5 EDO05760.1 - 7.5e-14 51.6 0.0 1.6e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 EDO05760.1 - 2.3e-06 27.3 0.2 0.0005 19.7 0.0 2.7 3 0 0 3 3 3 2 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EDO05760.1 - 0.0053 16.7 0.0 0.055 13.4 0.0 2.4 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 EDO05760.1 - 0.13 11.5 0.0 0.27 10.5 0.0 1.4 1 0 0 1 1 1 0 Putative beta-lactamase-like family MMR_HSR1_C PF08438.10 EDO05761.1 - 7.5e-31 107.0 0.0 1.3e-30 106.3 0.0 1.4 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 EDO05761.1 - 2.4e-18 66.3 0.0 5.8e-18 65.0 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 EDO05761.1 - 0.00054 19.9 0.0 0.0011 18.9 0.0 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EDO05761.1 - 0.0016 18.0 0.1 0.0073 15.9 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EDO05761.1 - 0.022 14.7 0.0 0.36 10.7 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase HSP20 PF00011.21 EDO05762.1 - 1.4e-12 47.6 0.1 2.3e-12 47.0 0.1 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EDO05762.1 - 5.7e-07 29.0 0.0 1e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA Plasmo_rep PF12135.8 EDO05762.1 - 0.027 14.0 0.0 0.061 12.9 0.0 1.5 1 0 0 1 1 1 0 Plasmodium repeat family Lung_7-TM_R PF06814.13 EDO05763.1 - 1.5e-06 27.7 10.7 2.3e-06 27.1 10.7 1.2 1 0 0 1 1 1 1 Lung seven transmembrane receptor GpcrRhopsn4 PF10192.9 EDO05763.1 - 0.00032 20.2 6.7 0.00072 19.0 6.7 1.7 1 0 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain Ribosomal_L34e PF01199.18 EDO05765.1 - 3.1e-41 139.6 9.6 3.1e-41 139.6 9.6 1.9 2 0 0 2 2 2 1 Ribosomal protein L34e Nup54_C PF18437.1 EDO05765.1 - 0.085 12.8 0.1 0.14 12.1 0.1 1.2 1 0 0 1 1 1 0 Nup54 C-terminal interacting domain Pox_A3L PF05288.11 EDO05765.1 - 0.16 12.0 1.6 0.22 11.5 0.1 1.9 2 0 0 2 2 2 0 Poxvirus A3L Protein tRNA-synt_2 PF00152.20 EDO05766.1 - 5.3e-64 216.3 0.2 8e-64 215.7 0.2 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDO05766.1 - 3.7e-09 36.4 0.1 7.3e-09 35.5 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Lzipper-MIP1 PF14389.6 EDO05766.1 - 0.01 16.1 0.0 0.025 14.9 0.0 1.6 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 AAA PF00004.29 EDO05767.1 - 3.4e-93 309.0 0.0 3.2e-45 153.8 0.1 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO05767.1 - 4e-26 90.6 6.6 7e-13 48.2 0.2 3.0 2 1 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 EDO05767.1 - 2.2e-14 53.5 0.0 8.4e-06 25.6 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDO05767.1 - 2.1e-13 51.0 0.2 7.8e-05 23.1 0.0 4.0 2 2 0 2 2 2 2 AAA ATPase domain AAA_2 PF07724.14 EDO05767.1 - 5.2e-12 46.2 0.0 1.2e-05 25.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EDO05767.1 - 8.3e-12 45.3 0.1 3.4e-05 23.8 0.1 3.6 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EDO05767.1 - 9.6e-11 42.0 0.0 1.6e-05 25.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 EDO05767.1 - 4.1e-10 39.4 1.6 7.8e-05 22.0 0.1 2.7 3 0 0 3 3 3 2 TIP49 P-loop domain AAA_22 PF13401.6 EDO05767.1 - 8.8e-10 39.0 0.6 0.046 14.0 0.0 4.0 3 2 1 4 4 3 2 AAA domain AAA_14 PF13173.6 EDO05767.1 - 1.5e-09 38.0 0.0 0.0007 19.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 EDO05767.1 - 1.1e-07 31.7 0.1 0.015 15.1 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein RNA_helicase PF00910.22 EDO05767.1 - 2.1e-07 31.3 0.0 0.016 15.6 0.0 2.7 2 0 0 2 2 2 2 RNA helicase Vps4_C PF09336.10 EDO05767.1 - 6.5e-07 29.3 0.1 7.6e-06 25.8 0.0 2.6 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain Mg_chelatase PF01078.21 EDO05767.1 - 8.2e-07 28.6 0.3 0.019 14.4 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EDO05767.1 - 9e-07 29.3 0.0 0.017 15.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EDO05767.1 - 1e-06 29.3 0.1 0.087 13.4 0.0 2.9 2 1 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 EDO05767.1 - 1.2e-06 28.4 0.0 0.0041 16.9 0.0 2.4 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase Bac_DnaA PF00308.18 EDO05767.1 - 3.1e-06 27.2 0.0 0.092 12.6 0.0 3.4 3 0 0 3 3 3 2 Bacterial dnaA protein Parvo_NS1 PF01057.17 EDO05767.1 - 5.8e-06 25.6 0.1 0.034 13.2 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 NACHT PF05729.12 EDO05767.1 - 6.5e-06 26.2 0.5 0.33 10.9 0.0 3.5 3 1 0 3 3 3 2 NACHT domain TsaE PF02367.17 EDO05767.1 - 7.6e-06 25.9 0.0 0.11 12.6 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 EDO05767.1 - 1.2e-05 24.7 1.2 0.031 13.6 0.0 3.1 3 0 0 3 3 2 2 Zeta toxin ABC_tran PF00005.27 EDO05767.1 - 2.3e-05 24.9 0.0 0.27 11.8 0.0 2.6 2 0 0 2 2 2 2 ABC transporter CDC48_N PF02359.18 EDO05767.1 - 2.5e-05 24.3 0.2 0.00011 22.3 0.3 2.0 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain Sigma54_activat PF00158.26 EDO05767.1 - 2.6e-05 24.0 0.1 0.32 10.7 0.0 3.4 2 2 0 2 2 2 2 Sigma-54 interaction domain AAA_17 PF13207.6 EDO05767.1 - 3.6e-05 24.2 0.0 0.62 10.5 0.0 3.0 2 0 0 2 2 2 2 AAA domain ATPase PF06745.13 EDO05767.1 - 4.5e-05 22.9 0.1 0.037 13.4 0.0 2.7 2 1 0 2 2 2 1 KaiC Sigma54_activ_2 PF14532.6 EDO05767.1 - 6.2e-05 23.1 0.0 0.56 10.3 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_7 PF12775.7 EDO05767.1 - 7.4e-05 22.3 0.1 0.25 10.8 0.0 2.5 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_25 PF13481.6 EDO05767.1 - 0.00011 21.9 0.3 1.5 8.4 0.0 3.4 2 1 0 3 3 3 1 AAA domain AAA_3 PF07726.11 EDO05767.1 - 0.00013 21.8 0.0 0.35 10.7 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 EDO05767.1 - 0.0003 20.1 0.0 0.44 9.7 0.0 2.6 3 0 0 3 3 3 2 NB-ARC domain AAA_11 PF13086.6 EDO05767.1 - 0.00033 20.5 0.0 0.5 10.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain PhoH PF02562.16 EDO05767.1 - 0.00037 20.0 0.1 0.6 9.5 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_19 PF13245.6 EDO05767.1 - 0.00064 20.1 0.4 1.4 9.3 0.4 3.5 4 0 0 4 4 2 1 AAA domain DUF2075 PF09848.9 EDO05767.1 - 0.00067 19.0 0.2 0.23 10.7 0.0 2.6 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) DUF815 PF05673.13 EDO05767.1 - 0.00092 18.4 0.0 0.49 9.5 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Hydin_ADK PF17213.3 EDO05767.1 - 0.0011 19.3 1.6 0.24 11.7 0.0 3.3 3 0 0 3 3 3 1 Hydin Adenylate kinase-like domain NTPase_1 PF03266.15 EDO05767.1 - 0.0014 18.6 0.2 17 5.3 0.0 4.1 3 1 1 4 4 4 0 NTPase AAA_24 PF13479.6 EDO05767.1 - 0.0016 18.2 0.0 2 8.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EDO05767.1 - 0.0029 17.3 0.1 0.38 10.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain Cytidylate_kin2 PF13189.6 EDO05767.1 - 0.0042 17.2 0.4 1.6 8.8 0.0 2.9 3 0 0 3 3 3 1 Cytidylate kinase-like family Rad17 PF03215.15 EDO05767.1 - 0.0063 16.5 0.0 1.1 9.2 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain ATPase_2 PF01637.18 EDO05767.1 - 0.0099 15.8 0.2 1.2 9.0 0.0 2.9 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_23 PF13476.6 EDO05767.1 - 0.014 15.9 0.1 6.9 7.1 0.1 2.8 2 1 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 EDO05767.1 - 0.015 15.0 0.1 1.9 8.2 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase ResIII PF04851.15 EDO05767.1 - 0.017 15.2 0.0 4.7 7.2 0.0 2.6 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit DAP3 PF10236.9 EDO05767.1 - 0.033 13.4 0.0 3.9 6.6 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_6 PF12774.7 EDO05767.1 - 0.042 12.8 0.1 0.15 11.0 0.0 1.8 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region KAP_NTPase PF07693.14 EDO05767.1 - 0.047 12.9 0.0 2.1 7.5 0.0 2.2 2 0 0 2 2 2 0 KAP family P-loop domain Torsin PF06309.11 EDO05767.1 - 0.12 12.5 0.0 3.7 7.7 0.0 2.5 2 0 0 2 2 2 0 Torsin SKI PF01202.22 EDO05767.1 - 0.14 12.3 0.1 10 6.2 0.0 2.6 2 0 0 2 2 2 0 Shikimate kinase DNA_mis_repair PF01119.19 EDO05768.1 - 1.2e-26 92.8 0.1 2.6e-26 91.6 0.1 1.6 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain MutL_C PF08676.11 EDO05768.1 - 2.2e-14 53.4 0.0 3.5e-13 49.5 0.0 2.6 1 1 0 1 1 1 1 MutL C terminal dimerisation domain HATPase_c_3 PF13589.6 EDO05768.1 - 2.5e-08 33.9 0.3 2.5e-08 33.9 0.3 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EDO05768.1 - 0.00065 20.2 0.1 0.0022 18.5 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase UCH PF00443.29 EDO05770.1 - 5.9e-43 147.2 0.3 9.5e-43 146.5 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDO05770.1 - 5.1e-12 46.0 0.6 1.3e-06 28.3 0.1 2.5 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 EDO05770.1 - 9.4e-08 32.0 0.1 4.5e-07 29.8 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin-specific protease C-terminal USP7_ICP0_bdg PF12436.8 EDO05770.1 - 0.073 12.4 0.0 0.59 9.4 0.0 2.6 2 1 0 2 2 2 0 ICP0-binding domain of Ubiquitin-specific protease 7 LINES_C PF14695.6 EDO05770.1 - 0.16 11.4 0.0 0.42 10.1 0.0 1.8 1 0 0 1 1 1 0 Lines C-terminus RPA_interact_M PF14767.6 EDO05771.1 - 0.11 13.1 5.9 0.19 12.3 5.9 1.3 1 0 0 1 1 1 0 Replication protein A interacting middle Wbp11 PF09429.10 EDO05772.1 - 0.025 15.0 2.4 0.05 14.0 2.4 1.5 1 0 0 1 1 1 0 WW domain binding protein 11 Fzo_mitofusin PF04799.13 EDO05772.1 - 0.049 13.2 0.6 0.079 12.5 0.6 1.3 1 0 0 1 1 1 0 fzo-like conserved region CCDC-167 PF15188.6 EDO05772.1 - 0.094 13.1 4.7 0.26 11.6 4.7 1.8 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 COX16 PF14138.6 EDO05772.1 - 0.65 10.5 2.9 3.4 8.2 2.3 2.5 2 1 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 EPSP_synthase PF00275.20 EDO05773.1 - 0.072 11.8 0.1 0.12 11.0 0.1 1.2 1 0 0 1 1 1 0 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAS_I_H PF18314.1 EDO05773.1 - 0.12 12.0 7.1 0.16 11.6 0.3 3.3 3 0 0 3 3 3 0 Fatty acid synthase type I helical domain Methyltr_RsmB-F PF01189.17 EDO05774.1 - 3.8e-21 75.6 0.0 9.6e-21 74.3 0.0 1.7 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.6 EDO05774.1 - 0.0011 18.8 0.0 0.0025 17.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDO05774.1 - 0.021 15.5 0.0 0.16 12.7 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Vps51 PF08700.11 EDO05775.1 - 4.4e-11 42.7 0.8 3.9e-10 39.7 0.2 2.8 2 0 0 2 2 2 1 Vps51/Vps67 DegQ PF08181.11 EDO05775.1 - 0.17 12.0 0.8 0.64 10.2 0.2 2.4 2 0 0 2 2 2 0 DegQ (SacQ) family Hist_deacetyl PF00850.19 EDO05777.1 - 3.5e-69 233.6 0.0 6.6e-69 232.7 0.0 1.4 1 0 0 1 1 1 1 Histone deacetylase domain Ank_4 PF13637.6 EDO05777.1 - 1e-08 35.5 0.7 0.0005 20.6 0.1 3.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EDO05777.1 - 2e-07 31.1 0.0 0.0052 17.1 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDO05777.1 - 9.8e-06 26.1 1.3 0.18 12.4 0.0 3.6 4 0 0 4 4 4 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDO05777.1 - 0.00018 21.7 0.9 1.6 9.5 0.1 4.0 3 0 0 3 3 3 2 Ankyrin repeat Ssl1 PF04056.14 EDO05778.1 - 1.3e-50 171.9 0.0 1.8e-50 171.4 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like VWA_2 PF13519.6 EDO05778.1 - 2.6e-09 37.7 0.0 5.3e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EDO05778.1 - 2.8e-06 27.7 0.0 5.6e-06 26.7 0.0 1.5 2 0 0 2 2 2 1 von Willebrand factor type A domain Tfb4 PF03850.14 EDO05778.1 - 0.0025 17.3 1.8 0.003 17.1 1.8 1.4 1 1 0 1 1 1 1 Transcription factor Tfb4 VWA_3 PF13768.6 EDO05778.1 - 0.032 14.2 0.0 0.27 11.2 0.0 2.0 1 1 1 2 2 2 0 von Willebrand factor type A domain Clathrin PF00637.20 EDO05779.1 - 6.3e-148 486.5 18.3 1.8e-29 102.4 0.5 7.5 7 0 0 7 7 7 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 EDO05779.1 - 3e-22 78.3 0.1 2.9e-21 75.1 0.0 2.8 3 0 0 3 3 3 1 Clathrin-H-link Coatomer_WDAD PF04053.14 EDO05779.1 - 8.1e-06 25.1 2.1 0.15 11.0 0.1 3.6 3 0 0 3 3 3 2 Coatomer WD associated region TPR_1 PF00515.28 EDO05779.1 - 6.6e-05 22.6 6.5 0.12 12.2 0.0 5.1 4 0 0 4 4 4 1 Tetratricopeptide repeat Clathrin_propel PF01394.20 EDO05779.1 - 0.00063 19.9 0.0 0.17 12.3 0.0 2.8 2 0 0 2 2 2 1 Clathrin propeller repeat TPR_2 PF07719.17 EDO05779.1 - 0.0017 18.3 10.9 0.062 13.4 0.0 5.8 5 0 0 5 5 4 1 Tetratricopeptide repeat AEP1 PF17049.5 EDO05779.1 - 0.018 14.1 1.6 4.3 6.3 0.0 3.4 3 0 0 3 3 3 0 ATPase expression protein 1 TPR_8 PF13181.6 EDO05779.1 - 0.024 14.9 2.7 1.4 9.3 0.0 4.8 5 0 0 5 5 4 0 Tetratricopeptide repeat Calpain_inhib PF00748.19 EDO05779.1 - 0.22 12.0 1.5 5.7 7.4 0.3 2.6 2 1 1 3 3 3 0 Calpain inhibitor TPR_14 PF13428.6 EDO05779.1 - 0.24 12.3 9.8 2.6e+02 2.9 0.1 7.6 9 0 0 9 9 7 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO05779.1 - 0.39 11.0 5.2 7.6 6.8 0.1 5.2 6 0 0 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EDO05779.1 - 2.4 8.4 13.4 20 5.5 0.1 6.6 8 0 0 8 8 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDO05779.1 - 3.2 8.5 6.0 11 6.8 0.8 4.2 3 1 0 3 3 3 0 Tetratricopeptide repeat PhoLip_ATPase_C PF16212.5 EDO05780.1 - 1.7e-57 195.0 21.7 1.7e-57 195.0 21.7 2.2 2 0 0 2 2 2 2 Phospholipid-translocating P-type ATPase C-terminal E1-E2_ATPase PF00122.20 EDO05780.1 - 3.6e-07 29.9 9.3 9.4e-07 28.5 0.1 3.3 3 0 0 3 3 3 2 E1-E2 ATPase Hydrolase PF00702.26 EDO05780.1 - 5e-07 30.2 0.0 0.0061 16.9 0.0 3.4 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EDO05780.1 - 0.011 15.5 0.0 0.046 13.5 0.0 2.1 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase GATase_4 PF13230.6 EDO05780.1 - 0.077 11.9 0.0 0.17 10.8 0.0 1.5 1 0 0 1 1 1 0 Glutamine amidotransferases class-II DEAD PF00270.29 EDO05781.1 - 2.9e-51 173.7 0.0 4.8e-51 173.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO05781.1 - 3.1e-34 117.6 0.1 1.1e-32 112.6 0.1 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO05781.1 - 0.00043 20.3 0.0 0.00074 19.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 EDO05781.1 - 0.12 11.1 0.0 0.32 9.7 0.0 1.7 1 1 0 1 1 1 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Med6 PF04934.14 EDO05783.1 - 6.4e-21 74.5 0.0 9.5e-21 74.0 0.0 1.3 1 0 0 1 1 1 1 MED6 mediator sub complex component DUF5380 PF17351.2 EDO05783.1 - 0.14 12.1 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5380) HECT_2 PF09814.9 EDO05784.1 - 0.00023 20.1 2.1 0.00078 18.4 0.0 2.3 2 1 0 3 3 3 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding SWM_repeat PF13753.6 EDO05784.1 - 0.043 14.0 3.1 0.06 13.5 0.7 2.1 2 0 0 2 2 2 0 Putative flagellar system-associated repeat Sua5_yciO_yrdC PF01300.18 EDO05785.1 - 1.1e-38 132.5 0.0 1.8e-38 131.8 0.0 1.2 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 EDO05785.1 - 3e-13 50.5 0.0 4.8e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding AAA PF00004.29 EDO05787.1 - 5.1e-16 59.3 0.2 4.1e-15 56.4 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDO05787.1 - 1.7e-10 41.3 0.0 4.6e-10 39.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDO05787.1 - 1.1e-08 35.6 0.0 3.8e-06 27.4 0.0 2.7 1 1 0 2 2 2 1 AAA ATPase domain AAA_lid_10 PF17872.1 EDO05787.1 - 5.6e-06 26.4 0.1 1.3e-05 25.2 0.1 1.5 1 0 0 1 1 1 1 AAA lid domain DUF2075 PF09848.9 EDO05787.1 - 3.3e-05 23.3 0.0 5.9e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 EDO05787.1 - 0.00059 19.8 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 NACHT domain RNA_helicase PF00910.22 EDO05787.1 - 0.0011 19.4 2.2 0.25 11.7 0.4 3.0 2 1 0 2 2 2 1 RNA helicase AAA_19 PF13245.6 EDO05787.1 - 0.0016 18.7 0.6 0.053 13.8 0.2 2.5 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 EDO05787.1 - 0.0038 17.2 8.1 0.0063 16.5 4.0 2.7 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea KAP_NTPase PF07693.14 EDO05787.1 - 0.028 13.7 1.5 0.28 10.4 0.4 2.3 1 1 1 2 2 2 0 KAP family P-loop domain ORC4_C PF14629.6 EDO05787.1 - 0.03 13.7 0.3 0.05 13.0 0.3 1.3 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 4 C-terminus RuvB_N PF05496.12 EDO05787.1 - 0.032 14.0 0.0 0.089 12.5 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 EDO05787.1 - 0.032 13.9 0.0 0.39 10.4 0.1 2.3 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 EDO05787.1 - 0.053 12.6 0.2 0.099 11.7 0.2 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ResIII PF04851.15 EDO05787.1 - 0.34 10.9 1.6 2 8.4 1.5 2.2 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit HMG_box PF00505.19 EDO05788.1 - 7.6e-26 90.3 2.3 1e-25 89.9 2.3 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EDO05788.1 - 7.2e-15 55.3 2.1 9.5e-15 54.9 2.1 1.2 1 0 0 1 1 1 1 HMG-box domain HMG_box_5 PF14887.6 EDO05788.1 - 0.016 15.2 2.1 0.028 14.4 2.1 1.6 1 1 0 1 1 1 0 HMG (high mobility group) box 5 DUF2582 PF10771.9 EDO05788.1 - 0.041 14.0 0.1 0.091 12.9 0.0 1.6 1 1 1 2 2 2 0 Winged helix-turn-helix domain (DUF2582) YABBY PF04690.13 EDO05788.1 - 0.19 12.3 1.4 0.25 11.9 1.1 1.3 1 1 0 1 1 1 0 YABBY protein AATF-Che1 PF13339.6 EDO05789.1 - 7e-06 26.8 6.2 8.1e-05 23.3 6.2 2.3 1 1 0 1 1 1 1 Apoptosis antagonizing transcription factor Dynein_attach_N PF15867.5 EDO05789.1 - 0.41 10.6 3.6 0.87 9.6 1.8 2.5 2 1 0 2 2 2 0 Dynein attachment factor N-terminus NFACT-R_1 PF05670.13 EDO05790.1 - 1.5e-30 106.0 0.0 2.8e-30 105.2 0.0 1.4 1 0 0 1 1 1 1 NFACT protein RNA binding domain FbpA PF05833.11 EDO05790.1 - 5.2e-28 98.0 0.2 3.1e-19 69.1 0.0 2.2 2 0 0 2 2 2 2 Fibronectin-binding protein A N-terminus (FbpA) NFACT-C PF11923.8 EDO05790.1 - 1e-16 60.8 0.0 2.6e-16 59.4 0.0 1.6 1 0 0 1 1 1 1 NFACT protein C-terminal domain Rav1p_C PF12234.8 EDO05791.1 - 9.8e-22 77.1 0.0 7.4e-19 67.6 0.3 2.4 2 1 0 2 2 2 2 RAVE protein 1 C terminal YqgF PF14639.6 EDO05791.1 - 0.13 12.1 0.0 0.33 10.7 0.0 1.6 1 0 0 1 1 1 0 Holliday-junction resolvase-like of SPT6 Peptidase_M24 PF00557.24 EDO05792.1 - 1.9e-46 158.4 0.5 6.6e-26 91.3 0.2 2.2 2 0 0 2 2 2 2 Metallopeptidase family M24 FHA PF00498.26 EDO05793.1 - 7.2e-21 74.3 0.9 1.5e-10 41.3 1.2 2.7 2 0 0 2 2 2 2 FHA domain zf-C3HC4_3 PF13920.6 EDO05793.1 - 2.6e-08 33.6 5.0 2.6e-08 33.6 5.0 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDO05793.1 - 2.9e-08 33.7 11.3 9.5e-08 32.1 11.3 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 EDO05793.1 - 2.1e-07 30.7 8.4 6.8e-07 29.1 8.4 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDO05793.1 - 5.1e-07 29.4 9.3 5.1e-07 29.4 9.3 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDO05793.1 - 7.1e-07 29.2 9.6 2.5e-06 27.4 9.6 2.0 1 0 0 1 1 1 1 RING-type zinc-finger Yop-YscD_cpl PF16697.5 EDO05793.1 - 4.4e-06 26.9 0.0 0.034 14.5 0.0 2.9 2 1 1 3 3 3 2 Inner membrane component of T3SS, cytoplasmic domain zf-RING_2 PF13639.6 EDO05793.1 - 6.4e-06 26.4 9.8 6.4e-06 26.4 9.8 2.7 3 0 0 3 3 2 1 Ring finger domain Prok-RING_4 PF14447.6 EDO05793.1 - 0.00055 19.7 6.6 0.0021 17.9 6.6 2.0 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EDO05793.1 - 0.0068 16.3 9.9 0.021 14.8 9.9 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_10 PF16685.5 EDO05793.1 - 0.032 14.4 3.7 0.086 13.0 3.7 1.7 1 0 0 1 1 1 0 zinc RING finger of MSL2 RGCC PF15151.6 EDO05793.1 - 0.093 13.0 0.0 0.28 11.4 0.0 1.8 1 0 0 1 1 1 0 Response gene to complement 32 protein family zf-RING_6 PF14835.6 EDO05793.1 - 0.37 10.7 8.2 0.33 10.9 5.8 2.2 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 EDO05793.1 - 0.58 10.5 8.0 1.8 8.9 8.0 1.9 1 0 0 1 1 1 0 RING-H2 zinc finger domain CactinC_cactus PF09732.9 EDO05797.1 - 4.5e-46 155.9 0.2 8e-46 155.1 0.2 1.4 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein Cactin_mid PF10312.9 EDO05797.1 - 1.5e-24 86.8 0.5 1.4e-23 83.7 0.5 2.1 1 1 0 1 1 1 1 Conserved mid region of cactin SHNi-TPR PF10516.9 EDO05798.1 - 2.1e-15 55.9 0.0 4.6e-14 51.6 0.0 2.3 2 0 0 2 2 2 1 SHNi-TPR TPR_12 PF13424.6 EDO05798.1 - 1.8e-09 37.7 0.2 1.2e-05 25.5 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDO05798.1 - 1.3e-08 34.3 0.1 0.013 15.5 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDO05798.1 - 1.8e-08 33.8 0.1 0.042 13.7 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDO05798.1 - 1.4e-06 28.1 1.5 0.11 12.7 0.0 4.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 EDO05798.1 - 9.1e-06 25.3 0.0 0.00049 19.7 0.0 2.9 3 0 0 3 3 3 1 TPR repeat SNAP PF14938.6 EDO05798.1 - 1.3e-05 24.7 5.6 3.5e-05 23.4 3.8 2.3 1 1 0 2 2 2 1 Soluble NSF attachment protein, SNAP TPR_MalT PF17874.1 EDO05798.1 - 0.00053 19.5 0.0 0.00079 18.9 0.0 1.3 1 0 0 1 1 1 1 MalT-like TPR region TPR_7 PF13176.6 EDO05798.1 - 0.0022 17.9 0.0 0.83 9.8 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDO05798.1 - 0.03 15.0 0.8 1.7 9.4 0.0 3.1 2 2 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 EDO05798.1 - 0.036 13.9 0.2 0.87 9.5 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDO05798.1 - 0.04 14.8 0.1 27 5.9 0.0 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat Myb_DNA-bind_7 PF15963.5 EDO05799.1 - 3.5e-22 78.1 0.5 3.5e-22 78.1 0.5 1.7 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 EDO05799.1 - 0.0056 16.9 0.0 0.039 14.2 0.0 2.1 1 1 1 2 2 2 1 Myb-like DNA-binding domain DUF726 PF05277.12 EDO05800.1 - 3.9e-81 272.7 0.2 7e-81 271.8 0.1 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF726) Cutinase PF01083.22 EDO05800.1 - 0.034 14.1 0.0 0.11 12.5 0.0 1.8 2 0 0 2 2 2 0 Cutinase DUF676 PF05057.14 EDO05800.1 - 0.054 13.0 0.0 0.14 11.6 0.0 1.6 1 0 0 1 1 1 0 Putative serine esterase (DUF676) VirJ PF06057.11 EDO05800.1 - 0.095 12.6 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) LIDHydrolase PF10230.9 EDO05800.1 - 0.15 11.5 0.1 4.7 6.7 0.0 2.5 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase DDR PF08841.10 EDO05800.1 - 1.7 7.5 5.0 3.3 6.6 5.0 1.4 1 1 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain UQ_con PF00179.26 EDO05801.1 - 2.9e-54 182.5 0.1 3.2e-54 182.4 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDO05801.1 - 6.3e-05 22.7 0.0 8.1e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EDO05801.1 - 0.012 15.9 0.0 0.013 15.8 0.0 1.3 1 0 0 1 1 1 0 RWD domain UEV PF05743.13 EDO05801.1 - 0.019 14.8 0.1 0.032 14.1 0.1 1.4 1 0 0 1 1 1 0 UEV domain NAP PF00956.18 EDO05802.1 - 2.3e-64 217.2 10.8 1.7e-62 211.1 10.8 2.2 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) Mst1_SARAH PF11629.8 EDO05802.1 - 0.91 9.6 6.3 0.14 12.3 1.5 2.1 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 Proteasome PF00227.26 EDO05803.1 - 5.6e-24 84.7 0.0 7.4e-24 84.3 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit PCNA_N PF00705.18 EDO05804.1 - 4.5e-43 146.0 1.6 8.3e-43 145.1 1.6 1.4 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 EDO05804.1 - 1.2e-25 90.1 0.0 2.2e-25 89.3 0.0 1.4 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 EDO05804.1 - 0.026 14.0 0.2 0.042 13.3 0.2 1.3 1 0 0 1 1 1 0 Rad9 EMC3_TMCO1 PF01956.16 EDO05805.1 - 0.003 17.3 0.0 0.0032 17.2 0.0 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like TIP49 PF06068.13 EDO05806.1 - 3.9e-143 476.9 0.0 5.1e-143 476.5 0.0 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EDO05806.1 - 1.2e-20 73.4 0.9 3.3e-20 72.0 0.9 1.9 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 EDO05806.1 - 9e-08 32.6 0.0 6.5e-05 23.4 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDO05806.1 - 1.1e-05 25.8 0.0 0.11 12.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 EDO05806.1 - 3.4e-05 23.3 1.0 0.00037 19.9 0.1 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 EDO05806.1 - 6.2e-05 23.5 1.2 0.00034 21.0 0.2 2.6 1 1 1 2 2 2 1 AAA ATPase domain DnaB_C PF03796.15 EDO05806.1 - 0.00017 21.0 0.0 0.00037 19.9 0.0 1.6 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain Zeta_toxin PF06414.12 EDO05806.1 - 0.00018 20.8 0.1 0.00054 19.3 0.0 1.7 2 0 0 2 2 2 1 Zeta toxin RuvB_N PF05496.12 EDO05806.1 - 0.0003 20.6 0.2 0.007 16.1 0.0 2.3 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain CPT PF07931.12 EDO05806.1 - 0.0017 18.2 0.0 0.07 13.0 0.0 2.4 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein AAA_17 PF13207.6 EDO05806.1 - 0.002 18.5 0.2 0.021 15.3 0.0 2.9 3 1 0 3 3 2 1 AAA domain Sigma54_activat PF00158.26 EDO05806.1 - 0.0032 17.2 0.1 0.17 11.6 0.0 2.3 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_19 PF13245.6 EDO05806.1 - 0.004 17.5 0.4 0.036 14.4 0.4 2.2 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EDO05806.1 - 0.0046 17.0 0.1 0.029 14.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 EDO05806.1 - 0.0082 15.9 0.2 0.04 13.7 0.1 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.6 EDO05806.1 - 0.015 15.8 0.0 0.081 13.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EDO05806.1 - 0.027 14.4 0.0 0.051 13.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_25 PF13481.6 EDO05806.1 - 0.027 14.0 0.7 0.06 12.9 0.2 1.8 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 EDO05806.1 - 0.074 12.4 0.4 0.16 11.3 0.4 1.5 1 0 0 1 1 1 0 KaiC IstB_IS21 PF01695.17 EDO05806.1 - 0.091 12.5 0.1 0.18 11.5 0.1 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.6 EDO05806.1 - 0.11 12.7 0.0 0.21 11.7 0.0 1.6 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 EDO05806.1 - 0.13 12.3 0.1 0.28 11.2 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NPCC PF08058.11 EDO05808.1 - 0.19 11.8 0.1 0.19 11.8 0.1 2.3 2 1 0 2 2 2 0 Nuclear pore complex component DUF382 PF04037.13 EDO05811.1 - 6.8e-53 178.2 3.4 6.8e-53 178.2 3.4 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF382) PSP PF04046.16 EDO05811.1 - 4.2e-22 77.8 2.9 1e-21 76.5 2.9 1.7 1 0 0 1 1 1 1 PSP DUF1676 PF07898.13 EDO05811.1 - 1.7 8.7 5.0 4.9 7.2 5.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) GlutR_dimer PF00745.20 EDO05811.1 - 6.5 7.3 10.9 4.7 7.7 3.1 3.3 3 0 0 3 3 3 0 Glutamyl-tRNAGlu reductase, dimerisation domain TPR_1 PF00515.28 EDO05812.1 - 5.4e-10 38.7 2.3 0.0021 17.8 0.6 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDO05812.1 - 6.1e-10 38.5 3.6 0.0011 18.9 0.7 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EDO05812.1 - 1.2e-06 28.0 5.8 0.00051 19.7 0.1 3.4 3 0 0 3 3 3 2 TPR repeat TPR_16 PF13432.6 EDO05812.1 - 1.5e-05 25.5 1.9 0.0029 18.2 0.5 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDO05812.1 - 1.6e-05 24.8 3.8 0.00027 20.9 0.7 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDO05812.1 - 0.0016 18.7 4.1 0.063 13.6 0.4 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 EDO05812.1 - 0.0018 18.4 0.3 0.0043 17.2 0.2 1.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 EDO05812.1 - 0.014 15.7 0.8 0.2 12.1 0.0 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDO05812.1 - 0.29 11.9 4.7 4.1 8.2 1.3 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat DEAD PF00270.29 EDO05813.1 - 1.9e-14 53.8 0.0 2.3e-14 53.6 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EDO05813.1 - 0.013 15.5 0.0 0.017 15.1 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 EDO05813.1 - 0.065 12.8 0.0 0.075 12.5 0.0 1.1 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain SBF_like PF13593.6 EDO05813.1 - 0.093 12.0 0.0 0.093 12.0 0.0 1.1 1 0 0 1 1 1 0 SBF-like CPA transporter family (DUF4137) TPR_2 PF07719.17 EDO05816.1 - 0.0053 16.8 0.3 0.13 12.4 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EDO05816.1 - 0.013 15.3 0.1 2.9 7.8 0.3 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 EDO05816.1 - 0.043 14.1 0.2 0.07 13.4 0.2 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat DEAD PF00270.29 EDO05817.1 - 1.7e-31 109.4 0.8 2.8e-31 108.6 0.8 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO05817.1 - 9.3e-22 77.5 0.0 2.3e-21 76.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO05817.1 - 2e-06 27.9 0.1 3.9e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDO05817.1 - 0.0021 18.3 2.4 0.011 16.0 0.6 3.0 2 1 1 3 3 3 1 AAA domain DUF2075 PF09848.9 EDO05817.1 - 0.0024 17.2 0.1 0.0044 16.3 0.1 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 EDO05818.1 - 1.3e-15 58.0 0.0 2.6e-15 57.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EDO05818.1 - 4.7e-13 49.2 0.1 4.1e-11 42.9 0.3 2.4 1 1 1 2 2 2 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 EDO05818.1 - 7.4e-13 48.7 0.2 4e-12 46.4 0.0 2.3 3 1 0 3 3 2 1 Replication factor C C-terminal domain AAA_16 PF13191.6 EDO05818.1 - 6.2e-07 30.0 0.0 0.0013 19.1 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_14 PF13173.6 EDO05818.1 - 1.8e-06 28.0 0.0 2.7e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EDO05818.1 - 2.1e-06 27.6 0.1 1.8e-05 24.5 0.1 2.2 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EDO05818.1 - 2.3e-06 28.0 0.5 0.0052 17.1 0.4 2.5 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EDO05818.1 - 2.4e-06 27.1 0.0 6.9e-05 22.3 0.0 2.2 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI Rad17 PF03215.15 EDO05818.1 - 8.2e-06 25.9 0.0 8.4e-05 22.6 0.0 2.3 1 1 1 2 2 2 1 Rad17 P-loop domain AAA_5 PF07728.14 EDO05818.1 - 2.1e-05 24.5 0.0 5.7e-05 23.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EDO05818.1 - 0.00023 21.0 0.0 0.00043 20.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EDO05818.1 - 0.00026 20.9 0.0 0.00034 20.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDO05818.1 - 0.00027 21.3 0.2 0.0085 16.4 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_25 PF13481.6 EDO05818.1 - 0.00044 19.9 0.2 0.0024 17.5 0.1 2.2 2 1 0 2 2 2 1 AAA domain DNA_pol3_delta PF06144.13 EDO05818.1 - 0.00045 20.0 0.2 0.0008 19.2 0.2 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit TniB PF05621.11 EDO05818.1 - 0.00048 19.6 0.1 0.17 11.3 0.0 2.3 2 0 0 2 2 2 1 Bacterial TniB protein AAA_7 PF12775.7 EDO05818.1 - 0.00083 18.9 0.0 0.0014 18.2 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region MCM PF00493.23 EDO05818.1 - 0.0033 16.6 0.0 0.0056 15.8 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain NTPase_1 PF03266.15 EDO05818.1 - 0.0033 17.3 1.0 1.7 8.5 0.1 2.4 1 1 1 2 2 2 2 NTPase AAA_assoc_2 PF16193.5 EDO05818.1 - 0.0034 17.7 0.0 0.0092 16.3 0.0 1.8 2 0 0 2 2 1 1 AAA C-terminal domain IstB_IS21 PF01695.17 EDO05818.1 - 0.0035 17.1 0.1 0.0089 15.8 0.1 1.7 1 1 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 EDO05818.1 - 0.0051 17.3 0.0 0.017 15.7 0.0 1.8 1 1 1 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.6 EDO05818.1 - 0.0052 16.9 0.0 0.022 14.9 0.0 1.9 1 1 0 1 1 1 1 Sigma-54 interaction domain DEAD PF00270.29 EDO05818.1 - 0.0052 16.6 0.2 0.59 9.9 0.0 2.4 1 1 1 2 2 2 1 DEAD/DEAH box helicase AAA_3 PF07726.11 EDO05818.1 - 0.0057 16.5 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 EDO05818.1 - 0.0089 15.8 0.0 0.019 14.7 0.0 1.5 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase SRP54 PF00448.22 EDO05818.1 - 0.031 13.9 0.0 0.073 12.7 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain RNA_helicase PF00910.22 EDO05818.1 - 0.039 14.3 0.0 0.17 12.3 0.0 2.1 1 1 0 1 1 1 0 RNA helicase AAA_30 PF13604.6 EDO05818.1 - 0.052 13.3 0.1 0.13 12.0 0.1 1.7 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 EDO05818.1 - 0.06 12.7 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF2385 PF09539.10 EDO05818.1 - 0.072 13.6 0.0 0.26 11.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2385) AAA_33 PF13671.6 EDO05818.1 - 0.086 13.0 0.2 0.14 12.3 0.2 1.6 1 1 0 1 1 1 0 AAA domain DUF2247 PF10004.9 EDO05818.1 - 0.11 12.2 0.0 0.3 10.8 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2247) Sigma54_activat PF00158.26 EDO05818.1 - 0.13 12.0 0.0 8 6.1 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF815 PF05673.13 EDO05818.1 - 0.13 11.4 0.0 0.23 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RBFA PF02033.18 EDO05819.1 - 1.6e-13 51.0 0.0 3.7e-13 49.8 0.0 1.6 1 0 0 1 1 1 1 Ribosome-binding factor A RseA_C PF03873.13 EDO05819.1 - 0.091 13.0 0.6 0.091 13.0 0.6 2.2 2 0 0 2 2 2 0 Anti sigma-E protein RseA, C-terminal domain S4 PF01479.25 EDO05820.1 - 9.6e-09 34.8 0.0 2.3e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 EDO05820.1 - 1e-08 36.0 3.2 1.6e-08 35.4 3.2 1.5 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain Ribosomal_L22e PF01776.17 EDO05820.1 - 0.053 13.9 2.3 0.14 12.5 2.3 1.8 1 0 0 1 1 1 0 Ribosomal L22e protein family Ribosomal_S28e PF01200.18 EDO05821.1 - 3.3e-32 110.3 1.3 3.6e-32 110.1 1.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e KCT2 PF17818.1 EDO05823.1 - 0.11 12.6 0.3 0.23 11.5 0.3 1.5 1 0 0 1 1 1 0 Keratinocyte-associated gene product MORN PF02493.20 EDO05825.1 - 1.2e-29 100.4 39.3 4.6e-06 26.2 0.2 7.9 7 0 0 7 7 7 7 MORN repeat ParA PF10609.9 EDO05826.1 - 2.6e-70 236.7 0.1 3.2e-70 236.4 0.1 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EDO05826.1 - 5.9e-10 39.3 0.0 9.8e-10 38.6 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EDO05826.1 - 1.1e-08 35.2 0.0 2.4e-08 34.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 EDO05826.1 - 2.1e-05 23.9 1.1 3.5e-05 23.1 0.1 1.9 2 1 1 3 3 3 1 Anion-transporting ATPase MipZ PF09140.11 EDO05826.1 - 0.00078 18.8 0.1 0.0037 16.6 0.1 1.9 2 0 0 2 2 2 1 ATPase MipZ NB-ARC PF00931.22 EDO05826.1 - 0.0012 18.1 0.2 0.0036 16.5 0.1 1.8 2 0 0 2 2 2 1 NB-ARC domain RsgA_GTPase PF03193.16 EDO05826.1 - 0.02 14.8 0.1 0.037 13.9 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase CBP_BcsQ PF06564.12 EDO05826.1 - 0.022 14.3 0.0 0.22 11.0 0.0 2.1 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ MeaB PF03308.16 EDO05826.1 - 0.024 13.6 0.2 0.035 13.1 0.2 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Mg_chelatase PF01078.21 EDO05826.1 - 0.037 13.4 0.1 0.063 12.7 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDO05826.1 - 0.053 13.5 0.0 0.19 11.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EDO05826.1 - 0.053 13.1 0.0 0.083 12.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EDO05826.1 - 0.11 12.9 0.0 0.18 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain DNA_primase_lrg PF04104.14 EDO05827.1 - 1.1e-65 221.8 0.0 1.6e-65 221.1 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Prenyltransf PF01255.19 EDO05828.1 - 1.5e-59 201.2 0.0 1.8e-59 201.0 0.0 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase SET PF00856.28 EDO05829.1 - 3.6e-18 66.5 0.6 3.1e-17 63.5 0.6 2.3 1 1 0 1 1 1 1 SET domain SAD_SRA PF02182.17 EDO05829.1 - 4.5e-14 52.4 0.0 8.8e-14 51.5 0.0 1.4 1 0 0 1 1 1 1 SAD/SRA domain Pre-SET PF05033.16 EDO05829.1 - 3.6e-12 46.9 1.1 1e-11 45.5 1.1 1.8 1 0 0 1 1 1 1 Pre-SET motif Thioredoxin PF00085.20 EDO05830.1 - 6.5e-46 154.6 0.0 3.3e-27 94.5 0.0 3.5 3 0 0 3 3 3 3 Thioredoxin Thioredoxin_6 PF13848.6 EDO05830.1 - 2.7e-29 102.4 0.1 1.3e-17 64.3 0.3 4.1 3 2 1 4 4 4 3 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EDO05830.1 - 1.2e-09 38.4 0.0 0.0016 18.7 0.0 4.3 4 2 2 6 6 6 2 Thioredoxin-like AhpC-TSA PF00578.21 EDO05830.1 - 4.4e-09 36.3 0.0 0.004 17.1 0.0 2.7 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_2 PF13098.6 EDO05830.1 - 1.2e-08 35.3 0.1 0.00097 19.6 0.0 3.2 4 0 0 4 4 4 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EDO05830.1 - 2.7e-07 30.2 0.0 0.00039 19.9 0.0 3.2 3 1 0 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 EDO05830.1 - 1.2e-06 28.6 0.0 0.045 13.9 0.0 3.0 3 0 0 3 3 3 2 Thioredoxin-like TraF PF13728.6 EDO05830.1 - 0.0081 16.0 0.0 3 7.6 0.0 2.6 2 0 0 2 2 2 2 F plasmid transfer operon protein Redoxin PF08534.10 EDO05830.1 - 0.02 14.6 0.1 0.5 10.1 0.0 2.5 3 0 0 3 3 3 0 Redoxin 2OG-FeII_Oxy_3 PF13640.6 EDO05831.1 - 3.7e-10 40.6 0.1 1.8e-09 38.4 0.0 2.0 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily LSM PF01423.22 EDO05832.1 - 5e-16 58.1 0.0 6.3e-16 57.8 0.0 1.1 1 0 0 1 1 1 1 LSM domain tRNA-synt_1 PF00133.22 EDO05834.1 - 5.6e-39 133.9 4.7 3.6e-24 85.0 0.1 6.0 2 2 4 6 6 6 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EDO05834.1 - 3.2e-24 85.4 0.1 8.6e-16 57.7 0.0 3.4 4 0 0 4 4 4 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EDO05834.1 - 1.2e-09 38.3 0.1 3.7e-09 36.7 0.1 1.8 1 1 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1_2 PF13603.6 EDO05834.1 - 3.3e-07 30.0 0.0 5.2e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EDO05834.1 - 0.00045 19.7 0.2 0.028 13.8 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain UPF0542 PF15086.6 EDO05834.1 - 0.013 15.5 0.0 0.028 14.3 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 ubiquitin PF00240.23 EDO05836.1 - 2.8e-14 52.6 0.0 4.8e-14 51.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EDO05836.1 - 1.1e-08 34.8 0.1 3.7e-08 33.1 0.1 1.9 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EDO05836.1 - 0.00025 21.5 0.0 0.00078 19.9 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EDO05836.1 - 0.02 15.0 0.0 0.088 12.9 0.0 2.0 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like PI_PP_I PF18363.1 EDO05836.1 - 0.1 12.8 0.1 0.26 11.5 0.1 1.7 2 0 0 2 2 2 0 Phosphoinositide phosphatase insertion domain DASH_Dam1 PF08653.10 EDO05836.1 - 0.13 12.1 1.0 0.27 11.1 0.3 1.9 2 0 0 2 2 2 0 DASH complex subunit Dam1 Methyltransf_11 PF08241.12 EDO05837.1 - 3.6e-13 50.0 0.0 5.4e-13 49.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDO05837.1 - 4.5e-10 40.1 0.0 7e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDO05837.1 - 1.7e-09 37.3 0.0 2.2e-09 37.0 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EDO05837.1 - 4.4e-08 33.1 0.0 6.4e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDO05837.1 - 7e-06 25.9 0.0 9.9e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDO05837.1 - 0.025 15.3 0.0 0.038 14.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF5475 PF17569.2 EDO05837.1 - 0.026 14.8 0.3 0.043 14.1 0.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5475) Tim17 PF02466.19 EDO05838.1 - 5.8e-19 68.5 4.4 7.3e-19 68.2 4.4 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family ERO1 PF04137.15 EDO05839.1 - 4.8e-69 233.2 0.0 5.8e-69 233.0 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) Beach PF02138.18 EDO05840.1 - 4.4e-95 318.2 0.1 6.3e-95 317.7 0.1 1.2 1 0 0 1 1 1 1 Beige/BEACH domain FIST PF08495.10 EDO05840.1 - 0.049 13.6 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 FIST N domain PLATZ PF04640.14 EDO05840.1 - 0.08 13.6 0.9 0.68 10.6 0.2 2.8 3 0 0 3 3 3 0 PLATZ transcription factor 60KD_IMP PF02096.20 EDO05841.1 - 5.3e-06 26.4 5.5 1e-05 25.5 5.5 1.5 1 1 0 1 1 1 1 60Kd inner membrane protein RVT_N PF13655.6 EDO05841.1 - 0.022 15.0 0.9 0.056 13.7 0.2 2.0 2 0 0 2 2 2 0 N-terminal domain of reverse transcriptase Band_7 PF01145.25 EDO05842.1 - 4.8e-25 88.6 1.0 7.6e-25 87.9 0.6 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family Capsid_VP7 PF17071.5 EDO05842.1 - 0.1 11.8 0.1 0.16 11.2 0.1 1.3 1 0 0 1 1 1 0 Outer capsid protein VP7 BT1 PF03092.16 EDO05843.1 - 8.3e-61 205.8 18.4 1.6e-42 145.4 5.7 2.0 2 0 0 2 2 2 2 BT1 family MFS_1 PF07690.16 EDO05843.1 - 1.5e-10 40.5 41.3 5.1e-08 32.2 22.7 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EDO05843.1 - 0.00066 18.6 8.8 0.00076 18.4 6.3 2.1 2 1 0 2 2 2 1 MFS_1 like family Cornifin PF02389.15 EDO05844.1 - 2.3e-05 24.6 35.1 2.3e-05 24.6 35.1 3.9 3 0 0 3 3 3 2 Cornifin (SPRR) family FliH PF02108.16 EDO05844.1 - 0.14 12.2 2.3 0.17 11.9 0.2 2.1 2 0 0 2 2 2 0 Flagellar assembly protein FliH RMI1_N PF08585.12 EDO05845.1 - 2.8e-10 40.4 0.6 8.4e-05 22.4 0.0 2.5 2 1 1 3 3 3 2 RecQ mediated genome instability protein Prok-RING_1 PF14446.6 EDO05846.1 - 0.0016 18.3 1.2 0.0031 17.4 1.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 zf-UDP PF14569.6 EDO05846.1 - 0.002 18.2 0.3 0.0039 17.3 0.3 1.5 1 0 0 1 1 1 1 Zinc-binding RING-finger zinc_ribbon_4 PF13717.6 EDO05846.1 - 0.016 15.1 4.3 0.094 12.7 0.4 2.5 2 0 0 2 2 2 0 zinc-ribbon domain DZR PF12773.7 EDO05846.1 - 0.027 14.5 3.5 0.043 13.9 3.5 1.3 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_5 PF13719.6 EDO05846.1 - 0.03 14.1 1.2 0.23 11.3 0.0 2.2 2 0 0 2 2 2 0 zinc-ribbon domain TerY_C PF15616.6 EDO05846.1 - 0.06 13.5 0.9 0.13 12.4 0.9 1.5 1 0 0 1 1 1 0 TerY-C metal binding domain PPR_2 PF13041.6 EDO05847.1 - 6.7e-58 192.7 22.0 1.4e-14 54.0 0.2 9.5 3 2 7 10 10 10 7 PPR repeat family PPR_1 PF12854.7 EDO05847.1 - 8e-49 163.0 15.3 1.4e-07 31.1 0.2 9.6 10 0 0 10 10 10 8 PPR repeat PPR PF01535.20 EDO05847.1 - 9e-49 160.4 24.3 3.5e-08 33.2 0.2 11.3 11 0 0 11 11 11 9 PPR repeat PPR_3 PF13812.6 EDO05847.1 - 3.1e-41 139.3 9.5 2.6e-11 43.4 0.1 7.8 7 1 2 9 9 9 6 Pentatricopeptide repeat domain PPR_long PF17177.4 EDO05847.1 - 1e-23 83.8 0.0 1.9e-11 43.7 0.0 5.2 4 1 1 5 5 5 3 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 EDO05847.1 - 2.9e-05 23.9 0.1 4.5 7.2 0.0 4.6 1 1 3 4 4 4 2 Mitochondrial ATPase expression MRP-S27 PF10037.9 EDO05847.1 - 0.00027 19.9 0.5 0.016 14.1 0.2 2.7 2 1 0 2 2 2 1 Mitochondrial 28S ribosomal protein S27 RPM2 PF08579.11 EDO05847.1 - 0.03 14.7 3.3 1.3 9.4 0.1 3.4 2 1 0 3 3 3 0 Mitochondrial ribonuclease P subunit (RPM2) TPR_19 PF14559.6 EDO05847.1 - 0.15 12.6 0.2 29 5.3 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat Brix PF04427.18 EDO05849.1 - 1.2e-24 87.4 0.1 1.7e-24 87.0 0.1 1.2 1 0 0 1 1 1 1 Brix domain EF-hand_8 PF13833.6 EDO05849.1 - 0.048 13.5 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain pair ParG PF09274.10 EDO05849.1 - 0.13 12.5 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 ParG Gaa1 PF04114.14 EDO05850.1 - 1e-07 31.4 7.3 7.8e-07 28.5 0.0 2.8 2 1 0 2 2 2 2 Gaa1-like, GPI transamidase component Vps36_ESCRT-II PF11605.8 EDO05851.1 - 0.16 12.1 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 ERCC4 PF02732.15 EDO05852.1 - 8.4e-18 65.1 0.0 4.9e-17 62.6 0.0 2.4 2 0 0 2 2 2 1 ERCC4 domain HA2 PF04408.23 EDO05853.1 - 4.8e-20 71.9 0.0 1.6e-19 70.2 0.0 1.9 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EDO05853.1 - 1.5e-15 57.3 0.0 5.5e-15 55.5 0.0 2.0 2 0 0 2 2 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EDO05853.1 - 9.9e-12 45.2 0.0 3.5e-11 43.4 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDO05853.1 - 9.5e-06 25.5 0.0 1.9e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDO05853.1 - 1.5e-05 25.3 0.0 5.2e-05 23.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDO05853.1 - 0.0014 18.4 0.0 0.0031 17.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDO05853.1 - 0.002 18.4 0.0 0.0058 17.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EDO05853.1 - 0.0088 16.1 0.1 0.15 12.1 0.1 2.5 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 EDO05853.1 - 0.018 14.4 0.0 0.044 13.1 0.0 1.6 1 0 0 1 1 1 0 KaiC Roc PF08477.13 EDO05853.1 - 0.022 15.0 0.2 7.1 6.9 0.0 2.9 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase DUF2075 PF09848.9 EDO05853.1 - 0.031 13.5 0.0 0.058 12.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) SRP54 PF00448.22 EDO05853.1 - 0.041 13.5 0.1 0.079 12.6 0.1 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ResIII PF04851.15 EDO05853.1 - 0.065 13.2 0.0 15 5.6 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 EDO05853.1 - 0.085 12.8 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain T2SSE PF00437.20 EDO05853.1 - 0.12 11.4 0.0 0.25 10.4 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC_tran PF00005.27 EDO05853.1 - 0.16 12.5 0.3 0.68 10.4 0.1 2.1 1 1 1 2 2 2 0 ABC transporter NUC173 PF08161.12 EDO05854.1 - 6.5e-11 42.3 0.7 9.2e-10 38.5 0.0 3.3 3 1 1 4 4 4 1 NUC173 domain CTD_bind PF04818.13 EDO05856.1 - 0.003 18.3 0.1 0.0092 16.8 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase II-binding domain. DUF4917 PF16263.5 EDO05858.1 - 0.059 12.7 0.0 0.12 11.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4917) DUF4602 PF15375.6 EDO05859.1 - 1.2e-11 45.1 11.1 3.4e-11 43.6 11.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4602) DUF5572 PF17733.1 EDO05859.1 - 0.058 13.2 0.9 0.058 13.2 0.9 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5572) DAAD PF18752.1 EDO05859.1 - 0.08 12.8 0.4 0.093 12.6 0.4 1.1 1 0 0 1 1 1 0 Dictyosteliid AID/APOBEC-like Deaminase tRNA-synt_2 PF00152.20 EDO05860.1 - 5.9e-73 245.7 0.0 8.3e-73 245.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDO05860.1 - 1.1e-11 44.5 0.0 2.8e-11 43.3 0.0 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EDO05860.1 - 6.6e-09 35.6 0.0 4.9e-05 22.9 0.0 2.5 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) LSM PF01423.22 EDO05861.1 - 2.3e-15 56.0 0.0 2.7e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EDO05861.1 - 0.016 14.9 0.0 0.024 14.3 0.0 1.5 1 1 0 1 1 1 0 Hfq protein PhnA PF03831.14 EDO05861.1 - 0.094 12.6 0.0 2.7 7.9 0.0 2.2 2 0 0 2 2 2 0 PhnA domain DNA_pol_A_exo1 PF01612.20 EDO05862.1 - 5.7e-43 146.7 0.1 1e-42 145.8 0.1 1.4 1 0 0 1 1 1 1 3'-5' exonuclease ERCC4 PF02732.15 EDO05864.1 - 1.8e-19 70.5 0.0 4.3e-19 69.2 0.0 1.7 1 1 0 1 1 1 1 ERCC4 domain DUF2959 PF11172.8 EDO05865.1 - 0.002 18.3 1.4 0.34 11.0 0.1 2.8 2 1 0 2 2 2 2 Protein of unknown function (DUF2959) Syntaxin-6_N PF09177.11 EDO05865.1 - 0.035 14.7 1.1 0.3 11.7 0.2 2.5 2 1 0 2 2 2 0 Syntaxin 6, N-terminal DUF818 PF05677.12 EDO05867.1 - 0.0011 17.9 0.0 0.0018 17.3 0.0 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Lipase_3 PF01764.25 EDO05867.1 - 0.051 13.4 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 Lipase (class 3) Xpo1 PF08389.12 EDO05868.1 - 8.7e-05 22.6 0.1 8.7e-05 22.6 0.1 3.4 4 1 1 5 5 5 1 Exportin 1-like protein TFIIB PF00382.19 EDO05869.1 - 4.4e-24 84.3 0.4 1.9e-12 47.0 0.1 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 EDO05869.1 - 6.3e-15 55.4 5.9 1.2e-14 54.5 5.9 1.4 1 0 0 1 1 1 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 EDO05869.1 - 2e-07 30.4 1.8 5e-07 29.1 1.8 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding A2L_zn_ribbon PF08792.10 EDO05869.1 - 0.0014 18.3 5.3 0.0035 17.0 5.3 1.7 1 0 0 1 1 1 1 A2L zinc ribbon domain zinc_ribbon_2 PF13240.6 EDO05869.1 - 0.031 14.0 1.3 0.76 9.6 0.1 2.8 2 0 0 2 2 2 0 zinc-ribbon domain zf-ribbon_3 PF13248.6 EDO05869.1 - 0.076 12.4 3.2 5.9 6.4 0.5 2.6 2 0 0 2 2 2 0 zinc-ribbon domain DUF2318 PF10080.9 EDO05869.1 - 0.17 12.0 3.6 0.4 10.8 3.6 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) HTH_28 PF13518.6 EDO05869.1 - 0.17 12.0 2.6 19 5.5 0.0 2.9 3 0 0 3 3 3 0 Helix-turn-helix domain OrfB_Zn_ribbon PF07282.11 EDO05869.1 - 0.37 10.8 4.2 1.3 9.0 4.2 1.9 1 0 0 1 1 1 0 Putative transposase DNA-binding domain E1-E2_ATPase PF00122.20 EDO05870.1 - 1.1e-22 80.4 1.9 1.4e-22 80.1 0.1 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EDO05870.1 - 3.8e-16 60.0 0.0 2e-07 31.5 0.0 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EDO05870.1 - 0.012 15.3 0.2 0.074 12.8 0.0 2.3 2 0 0 2 2 2 0 Cation transporter/ATPase, N-terminus DEAD PF00270.29 EDO05872.1 - 4.8e-36 124.1 0.0 8.1e-36 123.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO05872.1 - 2.5e-27 95.4 0.1 4.6e-26 91.3 0.1 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO05872.1 - 0.033 14.2 0.0 0.064 13.3 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit CMS1 PF14617.6 EDO05872.1 - 0.062 12.6 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Phage_TTP_13 PF16463.5 EDO05872.1 - 0.15 11.6 0.1 0.7 9.4 0.0 2.1 3 0 0 3 3 3 0 Phage tail tube protein family Ribosomal_L37ae PF01780.19 EDO05873.1 - 7.5e-36 122.1 6.2 8.5e-36 121.9 6.2 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.7 EDO05873.1 - 6.7e-05 22.8 3.1 9.8e-05 22.3 3.1 1.3 1 0 0 1 1 1 1 Transposase zinc-ribbon domain Elf1 PF05129.13 EDO05873.1 - 0.021 14.9 1.0 0.042 13.9 1.0 1.6 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-H2C2_2 PF13465.6 EDO05873.1 - 0.035 14.6 2.1 0.38 11.3 0.3 2.3 2 0 0 2 2 2 0 Zinc-finger double domain zf_UBZ PF18439.1 EDO05873.1 - 0.053 13.1 1.0 3.2 7.4 0.1 2.2 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Lar_restr_allev PF14354.6 EDO05873.1 - 0.063 13.7 2.0 0.11 12.9 2.0 1.4 1 1 0 1 1 1 0 Restriction alleviation protein Lar A2L_zn_ribbon PF08792.10 EDO05873.1 - 0.077 12.7 1.9 0.69 9.7 0.0 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain Zn-ribbon_8 PF09723.10 EDO05873.1 - 0.14 12.3 1.1 0.28 11.3 1.1 1.5 1 1 0 1 1 1 0 Zinc ribbon domain SecE PF00584.20 EDO05874.1 - 3.7e-13 49.2 0.0 4.5e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Sec20 PF03908.13 EDO05874.1 - 0.1 12.5 0.0 0.13 12.2 0.0 1.1 1 0 0 1 1 1 0 Sec20 ATP-synt_Eps PF04627.13 EDO05874.1 - 0.19 11.7 0.0 0.38 10.8 0.0 1.6 1 1 0 1 1 1 0 Mitochondrial ATP synthase epsilon chain SNF PF00209.18 EDO05875.1 - 7.6e-12 44.7 29.6 7.6e-12 44.7 29.6 2.1 2 0 0 2 2 2 2 Sodium:neurotransmitter symporter family HMW1C_N PF18071.1 EDO05876.1 - 0.1 12.4 0.7 0.45 10.3 0.1 2.2 2 0 0 2 2 2 0 HMW1C N-terminal Atg14 PF10186.9 EDO05876.1 - 9.3 5.2 8.0 23 3.9 8.0 1.6 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 NAD_kinase PF01513.21 EDO05877.1 - 4.2e-57 193.6 1.1 1.3e-56 192.0 1.0 1.7 1 1 1 2 2 2 1 ATP-NAD kinase DAGK_cat PF00781.24 EDO05877.1 - 9.7e-07 28.4 0.1 7.6e-06 25.6 0.0 2.2 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain YgbB PF02542.16 EDO05878.1 - 2.3e-45 154.7 0.2 2.7e-45 154.4 0.2 1.1 1 0 0 1 1 1 1 YgbB family DUF308 PF03729.13 EDO05880.1 - 0.068 13.5 5.6 4.8 7.6 0.6 2.8 2 0 0 2 2 2 0 Short repeat of unknown function (DUF308) YL1_C PF08265.11 EDO05880.1 - 0.097 12.5 0.0 11 5.8 0.0 2.5 2 0 0 2 2 2 0 YL1 nuclear protein C-terminal domain RBP_receptor PF14752.6 EDO05880.1 - 0.12 11.0 0.1 7.4 5.0 0.0 2.1 2 0 0 2 2 2 0 Retinol binding protein receptor DUF2530 PF10745.9 EDO05880.1 - 3.3 8.0 7.6 26 5.2 0.8 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) VESA1_N PF12785.7 EDO05881.1 - 2.6e-21 76.1 22.5 2e-11 43.6 5.9 4.1 3 1 1 4 4 4 3 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO05882.1 - 7.8e-197 654.7 19.7 3.3e-134 448.3 1.5 3.4 2 1 1 3 3 3 2 Variant erythrocyte surface antigen-1 UPF0020 PF01170.18 EDO05885.1 - 4e-10 39.7 0.0 0.00021 21.1 0.0 2.8 2 1 0 2 2 2 2 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 EDO05885.1 - 1.6e-06 28.0 0.0 0.0039 16.9 0.0 2.4 2 0 0 2 2 2 2 DNA methylase N6_Mtase PF02384.16 EDO05885.1 - 0.012 14.9 0.0 0.056 12.7 0.0 2.1 1 1 0 1 1 1 0 N-6 DNA Methylase N6-adenineMlase PF10237.9 EDO05885.1 - 0.056 13.3 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase DUF1764 PF08576.10 EDO05886.1 - 6.8e-24 84.7 0.8 6.8e-24 84.7 0.8 1.7 1 1 1 2 2 2 1 Eukaryotic protein of unknown function (DUF1764) Ndc1_Nup PF09531.10 EDO05886.1 - 0.037 12.7 6.5 0.04 12.6 6.5 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup THEG PF14912.6 EDO05886.1 - 0.15 12.5 1.8 0.37 11.3 0.1 2.1 1 1 1 2 2 2 0 Testicular haploid expressed repeat EFP PF01132.20 EDO05887.1 - 3.2e-06 27.1 0.1 4.9e-06 26.5 0.1 1.3 1 0 0 1 1 1 1 Elongation factor P (EF-P) OB domain Ras PF00071.22 EDO05888.1 - 2.3e-57 193.1 0.1 2.8e-57 192.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO05888.1 - 5.6e-34 116.9 0.0 1.1e-33 115.9 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO05888.1 - 3.4e-13 49.4 0.0 4.4e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EDO05888.1 - 2.5e-05 24.3 0.0 3.4e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDO05888.1 - 8.5e-05 22.2 0.1 0.0024 17.4 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EDO05888.1 - 0.00094 19.1 0.0 0.76 9.7 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EDO05888.1 - 0.025 13.9 0.0 0.031 13.6 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Dynamin_N PF00350.23 EDO05888.1 - 0.084 12.9 0.3 0.15 12.1 0.3 1.7 1 1 0 1 1 1 0 Dynamin family TP_methylase PF00590.20 EDO05889.1 - 3.6e-27 95.7 0.0 5.1e-27 95.2 0.0 1.2 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases PetM PF08041.11 EDO05889.1 - 0.33 10.6 2.7 0.63 9.7 2.7 1.5 1 0 0 1 1 1 0 PetM family of cytochrome b6f complex subunit 7 ADK PF00406.22 EDO05890.1 - 3.4e-51 173.3 0.0 4.4e-51 173.0 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EDO05890.1 - 1.2e-23 84.0 0.0 2.6e-23 83.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 EDO05890.1 - 5.7e-14 51.8 0.1 1.4e-13 50.6 0.1 1.7 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 EDO05890.1 - 5.2e-06 27.0 0.0 1.1e-05 26.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDO05890.1 - 7.1e-05 23.0 0.0 0.00016 21.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain Hydin_ADK PF17213.3 EDO05890.1 - 0.072 13.4 0.1 6.6 7.0 0.0 2.2 1 1 1 2 2 2 0 Hydin Adenylate kinase-like domain zf-C2H2_4 PF13894.6 EDO05891.1 - 2.7e-05 24.6 2.3 0.045 14.6 0.1 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EDO05891.1 - 0.0013 19.1 2.3 0.022 15.2 0.1 2.6 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EDO05891.1 - 0.011 16.0 6.0 0.21 11.9 1.0 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EDO05891.1 - 0.015 15.3 0.6 2.4 8.2 0.5 2.4 1 1 1 2 2 2 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 EDO05891.1 - 0.025 14.5 0.1 0.098 12.6 0.1 2.0 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zf-Di19 PF05605.12 EDO05891.1 - 0.099 13.0 4.5 2.2 8.6 0.9 2.4 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_12 PF11331.8 EDO05891.1 - 0.17 11.7 0.9 0.38 10.6 0.9 1.6 1 0 0 1 1 1 0 Probable zinc-ribbon domain LIM PF00412.22 EDO05891.1 - 0.28 11.4 2.7 0.52 10.6 2.7 1.4 1 0 0 1 1 1 0 LIM domain AMP-binding PF00501.28 EDO05892.1 - 0.00053 18.7 0.0 0.0014 17.3 0.0 1.7 1 1 0 1 1 1 1 AMP-binding enzyme Lactamase_B_6 PF16661.5 EDO05893.1 - 0.006 16.0 0.0 0.92 8.9 0.0 2.8 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily domain TBP PF00352.21 EDO05894.1 - 3.2e-55 184.0 0.5 1.2e-26 92.5 0.1 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) HTH_21 PF13276.6 EDO05894.1 - 0.073 13.2 0.0 0.46 10.7 0.0 2.1 1 1 1 2 2 2 0 HTH-like domain MIF4G PF02854.19 EDO05895.1 - 5.7e-23 81.7 0.2 8.3e-23 81.1 0.2 1.2 1 0 0 1 1 1 1 MIF4G domain DUF4551 PF15087.6 EDO05895.1 - 7 5.4 6.8 0.17 10.7 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4551) Wtap PF17098.5 EDO05896.1 - 5.7e-35 120.5 6.4 5.7e-35 120.5 6.4 3.1 2 1 0 2 2 2 1 WTAP/Mum2p family Ge1_WD40 PF16529.5 EDO05898.1 - 0.085 11.8 0.4 1.5 7.7 0.0 2.8 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40 PF00400.32 EDO05898.1 - 0.094 13.6 1.9 0.5 11.3 0.1 3.1 4 0 0 4 4 4 0 WD domain, G-beta repeat Myb_DNA-binding PF00249.31 EDO05900.1 - 6.2e-19 67.9 6.0 9.8e-11 41.7 1.3 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDO05900.1 - 3.5e-16 59.2 2.8 7.1e-11 42.2 2.6 2.9 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_Cef PF11831.8 EDO05900.1 - 4.3e-13 49.4 3.5 4.3e-13 49.4 3.5 2.9 2 2 1 3 3 3 1 pre-mRNA splicing factor component Rap1_C PF11626.8 EDO05900.1 - 0.14 12.3 1.1 0.75 9.9 0.1 2.6 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain SANT_DAMP1_like PF16282.5 EDO05900.1 - 0.18 12.0 0.9 0.7 10.1 0.7 2.2 1 1 0 1 1 1 0 SANT/Myb-like domain of DAMP1 Goodbye PF17109.5 EDO05900.1 - 0.21 12.1 0.6 0.48 10.9 0.0 1.9 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain FAM193_C PF15914.5 EDO05900.1 - 0.49 10.2 3.3 0.92 9.3 1.0 2.4 1 1 1 2 2 2 0 FAM193 family C-terminal RAP PF08373.10 EDO05901.1 - 4.2e-17 62.0 3.9 9e-17 60.9 3.9 1.6 1 0 0 1 1 1 1 RAP domain MTES_1575 PF18741.1 EDO05901.1 - 1.6e-05 24.9 0.0 3e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 REase_MTES_1575 DUF559 PF04480.12 EDO05901.1 - 0.00023 21.0 0.1 0.00055 19.8 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF559) MORN PF02493.20 EDO05903.1 - 1.9e-28 96.7 19.7 1.9e-06 27.4 0.1 7.7 8 0 0 8 8 8 7 MORN repeat DNA_pol3_delta2 PF13177.6 EDO05904.1 - 4.5e-11 42.8 0.0 7.4e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EDO05904.1 - 0.0037 17.2 0.0 0.0063 16.5 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 EDO05904.1 - 0.011 16.1 0.1 0.034 14.5 0.1 2.0 1 1 0 1 1 1 0 AAA ATPase domain FF PF01846.19 EDO05905.1 - 4.5e-09 36.4 4.5 4.5e-07 29.9 0.3 3.6 4 0 0 4 4 4 2 FF domain WW PF00397.26 EDO05905.1 - 0.00047 20.2 4.0 0.00085 19.4 4.0 1.4 1 0 0 1 1 1 1 WW domain CNOT1_CAF1_bind PF16415.5 EDO05906.1 - 5.5e-69 232.0 2.0 1.4e-68 230.6 2.0 1.7 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain Not1 PF04054.15 EDO05906.1 - 8.8e-41 140.0 0.3 6.9e-40 137.1 0.0 2.4 2 1 0 2 2 2 1 CCR4-Not complex component, Not1 CNOT1_TTP_bind PF16417.5 EDO05906.1 - 9.8e-39 132.5 0.1 2.5e-38 131.2 0.1 1.6 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain DUF3819 PF12842.7 EDO05906.1 - 7.4e-36 123.3 2.8 7.4e-36 123.3 2.8 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3819) zf-CHY PF05495.12 EDO05907.1 - 2.2e-12 47.3 11.7 2.2e-12 47.3 11.7 4.2 5 0 0 5 5 5 1 CHY zinc finger Myb_DNA-binding PF00249.31 EDO05907.1 - 3.6e-05 23.8 0.1 7.8e-05 22.8 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain zf-C3HC4_3 PF13920.6 EDO05907.1 - 0.013 15.3 4.5 0.013 15.3 4.5 3.9 4 1 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) Myb_DNA-bind_6 PF13921.6 EDO05907.1 - 0.021 15.0 0.3 0.042 14.1 0.3 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain Ribosomal_L40e PF01020.17 EDO05907.1 - 0.41 10.6 0.1 0.41 10.6 0.1 3.6 3 1 0 3 3 3 0 Ribosomal L40e family HD_3 PF13023.6 EDO05908.1 - 0.012 15.6 2.2 0.019 14.9 2.2 1.3 1 0 0 1 1 1 0 HD domain DUF760 PF05542.11 EDO05908.1 - 0.028 14.8 0.2 1.1 9.6 0.2 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF760) Gastrin PF00918.17 EDO05908.1 - 0.059 14.3 2.9 0.063 14.3 0.3 2.0 1 1 1 2 2 2 0 Gastrin/cholecystokinin family DUF5327 PF17261.2 EDO05908.1 - 0.76 10.5 6.3 0.59 10.9 0.2 2.4 1 1 1 2 2 2 0 Family of unknown function (DUF5327) cwf18 PF08315.12 EDO05908.1 - 4.2 8.0 7.6 21 5.8 7.6 1.9 1 1 0 1 1 1 0 cwf18 pre-mRNA splicing factor FmiP_Thoc5 PF09766.9 EDO05909.1 - 0.0068 15.7 0.9 0.011 15.1 0.9 1.2 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 Bap31_Bap29_C PF18035.1 EDO05909.1 - 0.071 13.1 0.2 0.15 12.1 0.2 1.5 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF2067 PF09840.9 EDO05909.1 - 0.096 12.3 0.1 0.15 11.6 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2067) DnaJ PF00226.31 EDO05910.1 - 0.061 13.5 0.1 0.22 11.7 0.1 2.0 1 1 0 1 1 1 0 DnaJ domain DUF3731 PF12531.8 EDO05910.1 - 0.25 11.1 1.2 0.41 10.4 1.2 1.2 1 0 0 1 1 1 0 DNA-K related protein Thioredoxin_8 PF13905.6 EDO05911.1 - 7.7e-17 61.4 0.0 1.1e-16 60.9 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 EDO05911.1 - 5.4e-06 26.3 0.0 6.4e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EDO05911.1 - 0.00062 19.5 0.0 0.00076 19.2 0.0 1.1 1 0 0 1 1 1 1 Redoxin SCO1-SenC PF02630.14 EDO05911.1 - 0.051 13.5 0.0 0.072 13.0 0.0 1.2 1 0 0 1 1 1 0 SCO1/SenC SNARE_assoc PF09335.11 EDO05912.1 - 1.4e-16 61.0 13.9 1.4e-16 61.0 13.9 2.4 2 1 1 3 3 3 1 SNARE associated Golgi protein Pex14_N PF04695.13 EDO05912.1 - 0.12 13.0 0.1 7.3 7.2 0.1 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Sugar_tr PF00083.24 EDO05913.1 - 3.3e-69 233.9 36.4 6e-69 233.0 36.4 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDO05913.1 - 1.6e-18 66.8 33.8 1.6e-18 66.8 33.8 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EDO05913.1 - 0.00035 19.1 7.1 0.00035 19.1 7.1 2.3 2 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF3302 PF11742.8 EDO05913.1 - 0.03 14.4 2.3 7.2 6.8 0.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3302) YscJ_FliF PF01514.17 EDO05913.1 - 0.063 12.9 0.2 0.1 12.3 0.2 1.3 1 0 0 1 1 1 0 Secretory protein of YscJ/FliF family Sugar_tr PF00083.24 EDO05914.1 - 4.8e-63 213.6 21.1 3.1e-45 154.9 8.7 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EDO05914.1 - 2.2e-20 72.9 8.1 2.2e-20 72.9 8.1 2.3 2 1 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EDO05914.1 - 9.7e-06 24.4 18.8 6.1e-05 21.8 0.4 4.0 3 1 0 4 4 4 4 MFS/sugar transport protein PPR PF01535.20 EDO05914.1 - 0.15 12.4 0.6 1.7 9.0 0.0 3.0 3 0 0 3 3 3 0 PPR repeat ubiquitin PF00240.23 EDO05915.1 - 5.8e-35 118.9 0.3 7.4e-35 118.5 0.3 1.1 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 EDO05915.1 - 5.1e-30 103.1 8.7 7.7e-30 102.5 8.7 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 EDO05915.1 - 6e-17 61.2 0.4 7.9e-17 60.9 0.4 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EDO05915.1 - 6e-06 26.6 0.1 2.1e-05 24.9 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EDO05915.1 - 0.0036 17.2 0.0 0.0048 16.8 0.0 1.2 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EDO05915.1 - 0.0055 16.8 0.0 0.013 15.6 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EDO05915.1 - 0.007 16.7 0.0 0.011 16.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_4 PF18036.1 EDO05915.1 - 0.024 14.7 0.7 6.9 6.8 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 EDO05915.1 - 0.062 13.9 0.0 0.069 13.7 0.0 1.3 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain TrmB PF01978.19 EDO05916.1 - 7.3e-05 22.6 0.5 0.00043 20.1 0.1 2.2 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB B-block_TFIIIC PF04182.12 EDO05916.1 - 0.0014 18.7 0.0 0.0035 17.4 0.0 1.7 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC DUF4423 PF14394.6 EDO05916.1 - 0.0041 16.8 0.0 0.011 15.4 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4423) GntR PF00392.21 EDO05916.1 - 0.01 15.5 0.2 0.027 14.1 0.2 1.7 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family HTH_24 PF13412.6 EDO05916.1 - 0.011 15.3 0.4 0.037 13.6 0.1 2.1 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding FaeA PF04703.12 EDO05916.1 - 0.018 15.4 0.1 0.042 14.2 0.1 1.6 1 0 0 1 1 1 0 FaeA-like protein HTH_20 PF12840.7 EDO05916.1 - 0.058 13.5 0.1 0.13 12.3 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_IclR PF09339.10 EDO05916.1 - 0.081 12.7 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_5 PF01022.20 EDO05916.1 - 0.096 12.6 0.1 0.18 11.7 0.1 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family DUF2250 PF10007.9 EDO05916.1 - 0.096 12.8 0.3 0.44 10.7 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) PaaX PF07848.12 EDO05916.1 - 0.12 12.6 0.0 0.24 11.7 0.0 1.4 1 0 0 1 1 1 0 PaaX-like protein MarR_2 PF12802.7 EDO05916.1 - 0.14 12.1 0.1 0.28 11.1 0.1 1.4 1 0 0 1 1 1 0 MarR family Pkinase PF00069.25 EDO05917.1 - 2.5e-80 269.6 0.1 3.3e-80 269.3 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO05917.1 - 3.2e-42 144.6 0.0 4.5e-42 144.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 EDO05917.1 - 3.6e-28 95.0 11.1 1.1e-06 27.8 0.1 4.7 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EDO05917.1 - 2.1e-22 77.1 9.7 2.7e-06 26.8 0.1 5.0 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 EDO05917.1 - 3.7e-22 78.5 7.7 1.5e-10 41.4 0.5 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EDO05917.1 - 3.6e-21 73.6 12.3 3.2e-06 26.4 0.2 4.7 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EDO05917.1 - 1.1e-15 57.3 9.8 0.00052 19.8 0.3 4.6 2 1 2 4 4 4 4 EF-hand domain pair Kinase-like PF14531.6 EDO05917.1 - 7.2e-07 28.8 0.0 0.079 12.3 0.0 3.1 3 0 0 3 3 3 3 Kinase-like Kdo PF06293.14 EDO05917.1 - 2.9e-06 26.8 0.1 7.9e-06 25.4 0.1 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EDO05917.1 - 4.5e-06 25.7 0.0 7.4e-06 25.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase SPARC_Ca_bdg PF10591.9 EDO05917.1 - 2.1e-05 24.8 0.6 0.54 10.6 0.0 3.3 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region APH PF01636.23 EDO05917.1 - 0.0012 18.9 0.1 0.018 15.0 0.0 2.4 2 1 0 3 3 3 1 Phosphotransferase enzyme family EF-hand_4 PF12763.7 EDO05917.1 - 0.0036 17.2 7.3 0.55 10.2 0.6 4.1 2 1 2 4 4 4 1 Cytoskeletal-regulatory complex EF hand DUF1654 PF07867.11 EDO05917.1 - 0.1 12.3 0.1 0.71 9.7 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1654) Hydrolase_3 PF08282.12 EDO05918.1 - 3.3e-38 131.9 1.7 3.8e-38 131.7 1.7 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EDO05918.1 - 2.4e-05 24.0 0.0 0.038 13.5 0.0 2.3 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EDO05918.1 - 0.011 16.0 0.0 0.056 13.7 0.0 2.0 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Acid_phosphat_B PF03767.14 EDO05918.1 - 0.045 13.3 1.8 2.3 7.8 0.1 2.9 2 2 1 3 3 3 0 HAD superfamily, subfamily IIIB (Acid phosphatase) Hydrolase_3 PF08282.12 EDO05919.1 - 8e-39 133.9 0.0 9.9e-39 133.6 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EDO05919.1 - 4.3e-08 33.0 0.0 3.8e-05 23.4 0.0 2.3 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EDO05919.1 - 1.9e-05 25.0 0.0 0.00024 21.5 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EDO05919.1 - 0.014 15.5 0.0 0.066 13.3 0.0 2.0 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase HAD PF12710.7 EDO05919.1 - 0.029 14.8 0.0 0.35 11.2 0.0 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EDO05920.1 - 3e-34 118.9 0.0 3.5e-34 118.7 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EDO05920.1 - 2.1e-07 30.7 0.0 0.0019 17.8 0.0 2.2 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EDO05920.1 - 0.0041 17.4 0.0 0.045 14.0 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase SecA_PP_bind PF01043.20 EDO05920.1 - 0.052 14.2 0.1 0.12 13.1 0.1 1.6 1 0 0 1 1 1 0 SecA preprotein cross-linking domain DUF3756 PF12581.8 EDO05921.1 - 0.11 12.4 0.1 0.19 11.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3756) NAP PF00956.18 EDO05923.1 - 7.9e-17 61.3 5.2 1.9e-13 50.3 0.1 2.2 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) Inhibitor_I71 PF12628.7 EDO05924.1 - 0.00069 19.5 0.0 0.021 14.6 0.0 2.0 1 1 0 1 1 1 1 Falstatin, cysteine peptidase inhibitor GTP_EFTU PF00009.27 EDO05925.1 - 9.9e-56 188.4 0.0 2e-55 187.4 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EDO05925.1 - 2.9e-15 56.1 0.0 6.2e-15 55.0 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 EDO05925.1 - 4.3e-06 26.7 0.0 8.3e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EDO05925.1 - 0.0012 19.2 0.0 0.0029 17.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDO05925.1 - 0.02 15.0 0.0 0.085 12.9 0.0 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase EFG_IV PF03764.18 EDO05925.1 - 0.082 12.7 0.0 0.96 9.2 0.0 2.4 2 0 0 2 2 2 0 Elongation factor G, domain IV PDCD2_C PF04194.13 EDO05926.1 - 3.2e-27 95.7 0.8 3.7e-25 89.0 0.2 2.2 2 0 0 2 2 2 2 Programmed cell death protein 2, C-terminal putative domain Lar_restr_allev PF14354.6 EDO05926.1 - 2.6 8.5 8.9 14 6.2 1.8 3.4 3 1 0 3 3 3 0 Restriction alleviation protein Lar Hydrolase_3 PF08282.12 EDO05927.1 - 4e-38 131.6 0.0 5e-38 131.3 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EDO05927.1 - 2.6e-05 23.9 0.0 0.059 12.9 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EDO05927.1 - 0.0002 21.8 0.0 0.0007 19.9 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase MBT PF02820.18 EDO05927.1 - 0.14 12.5 0.0 2.6 8.4 0.0 2.8 3 0 0 3 3 3 0 mbt repeat HAD_2 PF13419.6 EDO05927.1 - 0.16 12.0 0.0 0.65 10.1 0.0 1.9 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DMAP1_like PF17024.5 EDO05927.1 - 0.21 11.8 0.0 0.38 10.9 0.0 1.4 1 0 0 1 1 1 0 Putative DMAP1-like FIVAR PF07554.13 EDO05928.1 - 0.049 14.4 0.5 0.13 13.1 0.5 1.7 1 0 0 1 1 1 0 FIVAR domain WD40 PF00400.32 EDO05929.1 - 3.5e-23 81.5 0.8 1.2e-05 26.0 0.0 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO05929.1 - 4.6e-10 39.7 0.7 0.08 13.3 0.2 4.1 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ricin_B_lectin PF00652.22 EDO05929.1 - 0.013 15.7 2.5 0.29 11.4 0.2 2.3 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain DUF5046 PF16465.5 EDO05929.1 - 0.1 12.0 0.1 0.74 9.2 0.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF5046) Mcl1_mid PF12341.8 EDO05929.1 - 0.12 11.7 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Minichromosome loss protein, Mcl1, middle region Aminotran_5 PF00266.19 EDO05931.1 - 1.9e-112 375.9 0.3 5e-112 374.5 0.3 1.6 1 1 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EDO05931.1 - 4.8e-10 39.1 0.3 7.6e-10 38.5 0.3 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EDO05931.1 - 4.8e-05 22.1 0.1 6.7e-05 21.6 0.1 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EDO05931.1 - 5.4e-05 22.7 0.5 0.00011 21.7 0.2 1.5 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 EDO05931.1 - 0.00011 21.6 0.1 0.0005 19.4 0.0 1.8 1 1 0 2 2 2 1 Beta-eliminating lyase DUF5122 PF17164.4 EDO05931.1 - 0.099 12.9 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5122) beta-propeller NAD_kinase PF01513.21 EDO05932.1 - 1.9e-09 37.1 0.0 0.0014 17.8 0.0 2.8 3 0 0 3 3 3 2 ATP-NAD kinase DAGK_cat PF00781.24 EDO05932.1 - 0.0023 17.5 0.0 0.011 15.3 0.0 2.0 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain Glyco_trans_4_3 PF12000.8 EDO05932.1 - 0.17 11.6 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 4 group EF1_GNE PF00736.19 EDO05933.1 - 2.6e-28 98.0 2.4 2.6e-28 98.0 2.4 1.7 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 EDO05933.1 - 0.0048 17.3 3.1 0.0048 17.3 3.1 3.3 2 1 1 3 3 3 1 Eukaryotic elongation factor 1 beta central acidic region BDHCT_assoc PF16204.5 EDO05933.1 - 0.014 15.1 0.7 0.023 14.4 0.7 1.3 1 0 0 1 1 1 0 BDHCT-box associated domain on Bloom syndrome protein PBP1_TM PF14812.6 EDO05933.1 - 0.11 12.9 7.6 0.33 11.3 1.0 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FAM176 PF14851.6 EDO05933.1 - 0.46 10.1 5.2 7 6.3 0.2 2.1 2 0 0 2 2 2 0 FAM176 family DUF4611 PF15387.6 EDO05933.1 - 3 8.1 13.4 0.62 10.3 2.2 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4611) Kinesin PF00225.23 EDO05934.1 - 3.2e-86 289.3 0.4 4.2e-86 288.9 0.4 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EDO05934.1 - 1.6e-21 76.8 0.2 4.5e-21 75.3 0.1 1.8 2 0 0 2 2 2 1 Microtubule binding TFIIA PF03153.13 EDO05935.1 - 5.8e-06 26.6 0.1 7.6e-06 26.2 0.1 1.3 1 1 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Pro_isomerase PF00160.21 EDO05936.1 - 5.4e-42 143.7 0.0 6.9e-42 143.4 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Mito_carr PF00153.27 EDO05937.1 - 2.3e-40 136.4 2.2 6.7e-21 74.0 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein ATP_bind_1 PF03029.17 EDO05938.1 - 1.1e-54 185.7 0.1 1.4e-54 185.5 0.1 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MeaB PF03308.16 EDO05938.1 - 3.2e-05 23.0 0.0 8.7e-05 21.6 0.0 1.6 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB cobW PF02492.19 EDO05938.1 - 0.00036 20.2 0.0 0.00059 19.5 0.0 1.4 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_31 PF13614.6 EDO05938.1 - 0.00043 20.3 0.2 0.12 12.3 0.0 2.4 1 1 1 2 2 2 1 AAA domain NTPase_1 PF03266.15 EDO05938.1 - 0.001 19.0 0.2 0.0082 16.1 0.2 2.1 1 1 0 1 1 1 1 NTPase AAA_30 PF13604.6 EDO05938.1 - 0.0014 18.4 0.0 0.0017 18.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain CLP1_P PF16575.5 EDO05938.1 - 0.002 18.0 0.0 0.58 9.9 0.0 2.2 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop MobB PF03205.14 EDO05938.1 - 0.0024 17.8 0.0 0.0087 16.0 0.0 1.9 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B GTP_EFTU PF00009.27 EDO05938.1 - 0.0026 17.3 0.0 0.027 14.0 0.0 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain NACHT PF05729.12 EDO05938.1 - 0.0026 17.7 0.0 0.0038 17.2 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Pox_A32 PF04665.12 EDO05938.1 - 0.0028 17.2 0.0 0.0059 16.1 0.0 1.5 1 0 0 1 1 1 1 Poxvirus A32 protein AAA_7 PF12775.7 EDO05938.1 - 0.0036 16.9 0.0 0.0067 16.0 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region ATPase_2 PF01637.18 EDO05938.1 - 0.0048 16.8 0.0 0.007 16.3 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EDO05938.1 - 0.0065 16.8 0.0 0.012 15.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EDO05938.1 - 0.0098 15.5 0.2 0.084 12.5 0.2 2.1 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_14 PF13173.6 EDO05938.1 - 0.01 15.9 0.1 0.017 15.2 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EDO05938.1 - 0.013 15.9 0.0 0.02 15.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain MipZ PF09140.11 EDO05938.1 - 0.014 14.7 0.0 0.066 12.5 0.0 1.9 1 1 0 1 1 1 0 ATPase MipZ Septin PF00735.18 EDO05938.1 - 0.014 14.7 0.0 0.76 9.0 0.0 2.1 2 0 0 2 2 2 0 Septin MMR_HSR1 PF01926.23 EDO05938.1 - 0.015 15.4 0.0 0.027 14.6 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase T2SSE PF00437.20 EDO05938.1 - 0.016 14.3 0.0 0.024 13.7 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein TrwB_AAD_bind PF10412.9 EDO05938.1 - 0.016 14.1 0.0 0.022 13.7 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Gemini_BL1 PF00845.19 EDO05938.1 - 0.021 14.4 0.0 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 Geminivirus BL1 movement protein AAA_19 PF13245.6 EDO05938.1 - 0.031 14.6 0.0 0.047 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Flavoprotein PF02441.19 EDO05938.1 - 0.035 13.9 0.0 0.05 13.4 0.0 1.3 1 0 0 1 1 1 0 Flavoprotein CbiA PF01656.23 EDO05938.1 - 0.042 13.9 0.0 0.057 13.5 0.0 1.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_33 PF13671.6 EDO05938.1 - 0.053 13.7 0.0 0.093 12.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain KTI12 PF08433.10 EDO05938.1 - 0.057 12.9 0.0 0.091 12.2 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 DUF463 PF04317.12 EDO05938.1 - 0.057 12.3 0.0 0.12 11.3 0.0 1.5 1 1 0 1 1 1 0 YcjX-like family, DUF463 LpxK PF02606.14 EDO05938.1 - 0.062 12.4 0.1 0.087 11.9 0.1 1.2 1 0 0 1 1 1 0 Tetraacyldisaccharide-1-P 4'-kinase NB-ARC PF00931.22 EDO05938.1 - 0.073 12.2 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain DUF815 PF05673.13 EDO05938.1 - 0.075 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Thymidylate_kin PF02223.17 EDO05938.1 - 0.078 12.6 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Thymidylate kinase AAA_24 PF13479.6 EDO05938.1 - 0.082 12.6 0.1 0.16 11.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 EDO05938.1 - 0.085 12.9 0.1 0.17 12.0 0.1 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain ArsA_ATPase PF02374.15 EDO05938.1 - 0.12 11.6 0.1 0.28 10.3 0.1 1.6 1 1 0 1 1 1 0 Anion-transporting ATPase Roc PF08477.13 EDO05938.1 - 0.12 12.6 0.0 0.37 11.0 0.1 1.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 EDO05938.1 - 0.13 11.5 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family Zeta_toxin PF06414.12 EDO05938.1 - 0.14 11.4 0.1 0.32 10.2 0.0 1.6 2 0 0 2 2 1 0 Zeta toxin AAA PF00004.29 EDO05938.1 - 0.15 12.4 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EDO05938.1 - 0.19 12.3 0.1 0.35 11.4 0.1 1.6 1 1 0 1 1 1 0 AAA domain GAF PF01590.26 EDO05939.1 - 4.3e-13 50.1 0.3 1.1e-09 39.0 0.1 2.5 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.6 EDO05939.1 - 9.5e-09 35.7 0.0 2.1e-07 31.3 0.0 2.2 2 0 0 2 2 2 1 GAF domain GAF_3 PF13492.6 EDO05939.1 - 4.8e-07 30.2 0.0 2.3e-06 28.0 0.0 2.0 2 0 0 2 2 2 1 GAF domain Patatin PF01734.22 EDO05940.1 - 0.013 15.7 0.5 0.45 10.7 0.0 2.6 1 1 1 2 2 2 0 Patatin-like phospholipase CPSF_A PF03178.15 EDO05941.1 - 4.1e-16 59.2 0.0 3.7e-11 42.9 0.0 2.9 2 0 0 2 2 2 2 CPSF A subunit region DUF1869 PF08956.10 EDO05941.1 - 0.021 14.7 0.3 0.24 11.4 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1869) SICA_beta PF12878.7 EDO05941.1 - 0.036 14.2 1.1 0.58 10.3 0.0 2.6 2 0 0 2 2 2 0 SICA extracellular beta domain eRF1_2 PF03464.15 EDO05942.1 - 1e-45 155.3 0.0 1.6e-45 154.6 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EDO05942.1 - 2.8e-35 121.2 0.4 5.8e-35 120.2 0.4 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 EDO05942.1 - 2e-19 69.8 0.0 3.7e-19 69.0 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 EDO05942.1 - 6.6e-08 32.9 0.0 1.1e-07 32.2 0.0 1.4 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 EDO05942.1 - 8.1e-07 29.4 0.0 1.3e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 HSP70 PF00012.20 EDO05945.1 - 1.3e-268 892.1 7.6 1.5e-268 892.0 7.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDO05945.1 - 7.7e-17 61.1 4.4 2e-15 56.4 0.9 2.4 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 EDO05945.1 - 0.0051 16.6 0.0 0.014 15.2 0.0 1.8 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 EDO05945.1 - 0.0082 16.5 1.1 9.1 6.8 0.0 3.4 3 1 0 3 3 3 2 Cell division protein FtsA BcrAD_BadFG PF01869.20 EDO05945.1 - 0.021 14.3 0.2 3.1 7.2 0.0 2.4 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family DUF3135 PF11333.8 EDO05945.1 - 0.11 12.7 1.6 0.31 11.3 1.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3135) ATP-synt_B PF00430.18 EDO05945.1 - 0.39 10.8 5.4 0.72 9.9 4.5 1.9 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) CAML PF14963.6 EDO05945.1 - 3 7.9 9.4 5.5 7.0 9.4 1.4 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand Tom37 PF10568.9 EDO05946.1 - 0.0017 18.7 1.1 0.0028 17.9 1.1 1.6 1 1 0 1 1 1 1 Outer mitochondrial membrane transport complex protein MMTV_SAg PF01054.17 EDO05946.1 - 0.033 13.7 0.4 2.7 7.5 0.1 2.1 2 0 0 2 2 2 0 Mouse mammary tumour virus superantigen Ribosomal_S14 PF00253.21 EDO05947.1 - 2.6e-05 23.9 4.0 2.8e-05 23.8 0.8 2.3 3 0 0 3 3 3 1 Ribosomal protein S14p/S29e YL1 PF05764.13 EDO05948.1 - 0.0023 18.1 5.6 0.0023 18.1 5.6 2.3 2 1 0 2 2 2 1 YL1 nuclear protein EF-hand_9 PF14658.6 EDO05948.1 - 0.076 13.3 0.0 0.65 10.4 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain Folliculin PF11704.8 EDO05948.1 - 0.42 10.5 4.0 0.2 11.5 1.6 1.7 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport Presenilin PF01080.17 EDO05948.1 - 3.5 6.3 5.6 3.8 6.2 5.6 1.2 1 0 0 1 1 1 0 Presenilin RSB_motif PF16294.5 EDO05948.1 - 7.9 6.8 12.5 0.58 10.5 6.8 2.0 2 0 0 2 2 2 0 RNSP1-SAP18 binding (RSB) motif Ribosomal_S5 PF00333.20 EDO05950.1 - 2.6e-26 91.4 0.2 5.8e-26 90.3 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EDO05950.1 - 5.9e-20 70.5 0.0 1.1e-19 69.6 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain DUF3389 PF11869.8 EDO05951.1 - 0.0049 17.0 0.0 0.008 16.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3389) Glu_cyclase_2 PF05096.12 EDO05952.1 - 8e-26 91.0 0.0 4.9e-25 88.4 0.0 1.9 1 1 0 1 1 1 1 Glutamine cyclotransferase DHHC PF01529.20 EDO05953.1 - 1.1e-15 57.9 26.8 1.1e-15 57.9 26.8 3.4 2 2 0 2 2 2 1 DHHC palmitoyltransferase Phage_holin_3_6 PF07332.11 EDO05953.1 - 2.9 7.9 6.5 5.5 7.1 4.5 2.0 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III ORC5_C PF14630.6 EDO05955.1 - 0.00023 20.8 0.0 0.00048 19.7 0.0 1.5 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus Ribosomal_L12 PF00542.19 EDO05956.1 - 3.8e-22 78.4 1.0 5.8e-19 68.2 1.2 2.2 2 0 0 2 2 2 2 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 EDO05956.1 - 0.15 11.8 0.1 0.15 11.8 0.1 3.0 4 0 0 4 4 4 0 Ribosomal protein L7/L12 dimerisation domain TF_Zn_Ribbon PF08271.12 EDO05958.1 - 0.031 13.8 0.8 0.09 12.3 0.8 1.8 1 0 0 1 1 1 0 TFIIB zinc-binding DZR PF12773.7 EDO05958.1 - 0.19 11.8 0.8 0.4 10.7 0.8 1.5 1 0 0 1 1 1 0 Double zinc ribbon PhoLip_ATPase_C PF16212.5 EDO05959.1 - 1.7e-31 109.9 31.0 1.7e-31 109.9 31.0 2.3 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 EDO05959.1 - 1.6e-13 51.5 0.8 6.1e-08 33.2 0.4 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EDO05959.1 - 4.3e-10 39.4 8.1 3e-06 26.9 0.0 3.9 4 0 0 4 4 4 2 E1-E2 ATPase Cation_ATPase PF13246.6 EDO05959.1 - 2.5e-09 37.1 0.1 8.1e-09 35.5 0.0 1.8 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EDO05959.1 - 0.0013 18.6 0.1 0.0039 17.0 0.1 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase PhoLip_ATPase_N PF16209.5 EDO05959.1 - 0.087 12.5 0.4 0.24 11.1 0.4 1.8 1 0 0 1 1 1 0 Phospholipid-translocating ATPase N-terminal DNA_topoisoIV PF00521.20 EDO05960.1 - 4.1e-118 395.0 0.0 6.5e-118 394.3 0.0 1.3 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseA_C PF03989.13 EDO05960.1 - 4.2e-06 26.1 0.4 7.2 6.2 0.0 5.3 5 1 0 5 5 5 3 DNA gyrase C-terminal domain, beta-propeller HTH_3 PF01381.22 EDO05960.1 - 0.1 12.7 0.2 0.26 11.4 0.2 1.7 1 0 0 1 1 1 0 Helix-turn-helix HTH_31 PF13560.6 EDO05960.1 - 0.13 12.6 0.1 0.28 11.5 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_25 PF13413.6 EDO05960.1 - 2.3 8.2 3.8 0.49 10.3 0.2 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain YajC PF02699.15 EDO05961.1 - 0.0085 15.9 0.0 1.1e+02 2.7 0.0 4.4 4 0 0 4 4 4 2 Preprotein translocase subunit Big_3_3 PF13750.6 EDO05963.1 - 0.23 11.1 0.0 0.57 9.8 0.0 1.6 1 1 0 1 1 1 0 Bacterial Ig-like domain (group 3) VESA1_N PF12785.7 EDO05964.1 - 7e-10 38.5 9.4 8.7e-09 34.9 7.4 2.1 1 1 1 2 2 2 2 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO05965.1 - 3.6e-217 721.8 20.7 3.6e-217 721.8 20.7 2.4 3 0 0 3 3 1 1 Variant erythrocyte surface antigen-1 ALIX_LYPXL_bnd PF13949.6 EDO05965.1 - 0.017 14.4 0.8 0.028 13.7 0.8 1.2 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV Baculo_PEP_C PF04513.12 EDO05965.1 - 0.021 14.8 1.1 0.087 12.9 0.7 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus CdvA PF18822.1 EDO05965.1 - 0.11 12.3 3.8 0.5 10.2 3.8 2.1 1 1 0 1 1 1 0 CdvA-like coiled-coil domain TBCA PF02970.16 EDO05965.1 - 0.22 11.9 3.6 1.5 9.2 0.4 2.6 2 0 0 2 2 2 0 Tubulin binding cofactor A DUF1978 PF09321.10 EDO05965.1 - 0.28 10.5 2.1 0.46 9.7 2.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1978) DUF3584 PF12128.8 EDO05965.1 - 0.59 7.6 3.5 0.86 7.0 3.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Syntaxin_2 PF14523.6 EDO05965.1 - 0.7 10.3 2.9 5.1 7.5 0.1 2.7 3 0 0 3 3 3 0 Syntaxin-like protein PspA_IM30 PF04012.12 EDO05965.1 - 0.9 9.1 4.3 1.7 8.2 4.3 1.4 1 0 0 1 1 1 0 PspA/IM30 family APG17 PF04108.12 EDO05965.1 - 1.2 8.2 3.4 5.8 5.9 0.2 2.1 1 1 0 2 2 2 0 Autophagy protein Apg17 Prefoldin_2 PF01920.20 EDO05965.1 - 2 8.4 5.8 6.7 6.7 0.5 2.8 3 0 0 3 3 3 0 Prefoldin subunit Uso1_p115_C PF04871.13 EDO05965.1 - 3.9 7.8 9.7 12 6.3 2.1 2.3 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region HSCB_C PF07743.13 EDO05965.1 - 7.4 7.1 5.4 23 5.6 0.2 2.5 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain F-box-like_2 PF13013.6 EDO05967.1 - 3.7e-22 78.3 0.5 4.1e-18 65.3 0.2 2.1 2 0 0 2 2 2 2 F-box-like domain RseC_MucC PF04246.12 EDO05969.1 - 0.011 15.7 0.6 0.017 15.0 0.6 1.3 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Tmemb_55A PF09788.9 EDO05969.1 - 0.07 12.2 0.2 0.089 11.9 0.2 1.1 1 0 0 1 1 1 0 Transmembrane protein 55A OppC_N PF12911.7 EDO05969.1 - 0.11 12.5 0.7 0.11 12.5 0.7 2.8 3 1 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C ETRAMP PF09716.10 EDO05969.1 - 0.13 12.3 1.7 0.21 11.7 0.2 2.0 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Flp1_like PF16982.5 EDO05969.1 - 0.2 11.1 5.4 2.2 7.8 1.8 2.5 2 0 0 2 2 2 0 Putative Flagellin, Flp1-like, domain DUF2178 PF09946.9 EDO05969.1 - 0.33 11.2 6.1 0.14 12.4 3.7 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2178) DUF2207 PF09972.9 EDO05969.1 - 0.34 9.6 2.2 0.36 9.6 2.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Phage_holin_3_6 PF07332.11 EDO05969.1 - 0.57 10.2 10.4 0.054 13.5 5.6 1.7 1 1 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III CoA_binding_3 PF13727.6 EDO05970.1 - 0.059 13.4 0.6 0.059 13.4 0.6 2.1 2 0 0 2 2 2 0 CoA-binding domain DUF1279 PF06916.13 EDO05970.1 - 0.58 10.7 3.8 10 6.8 0.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1279) VESA1_N PF12785.7 EDO05971.1 - 1.7e-18 66.9 12.3 2.9e-10 39.7 7.1 4.0 4 1 1 5 5 5 3 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO05972.1 - 1.4e-225 749.5 15.2 1.4e-225 749.5 15.2 2.5 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 Baculo_PEP_C PF04513.12 EDO05972.1 - 0.03 14.4 6.4 5.3 7.1 0.1 4.6 4 1 1 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus MnmE_helical PF12631.7 EDO05972.1 - 0.17 12.0 2.8 0.17 12.0 0.9 2.0 2 0 0 2 2 2 0 MnmE helical domain Latarcin PF10279.9 EDO05972.1 - 0.26 11.7 1.2 6.4 7.3 1.2 2.8 1 1 0 1 1 1 0 Latarcin precursor TMEM100 PF16311.5 EDO05973.1 - 0.0023 17.5 0.3 0.88 9.2 0.1 3.3 3 0 0 3 3 3 1 Transmembrane protein 100 MscS_TM PF12794.7 EDO05973.1 - 0.014 14.2 0.1 0.014 14.2 0.1 3.9 3 1 0 4 4 4 0 Mechanosensitive ion channel inner membrane domain 1 DUF4239 PF14023.6 EDO05973.1 - 0.027 14.2 0.3 0.027 14.2 0.3 4.1 3 2 2 5 5 5 0 Protein of unknown function (DUF4239) PgaD PF13994.6 EDO05973.1 - 0.11 12.6 0.9 3.8 7.5 0.6 2.9 2 0 0 2 2 2 0 PgaD-like protein H_PPase PF03030.16 EDO05973.1 - 0.24 10.0 13.8 0.61 8.6 0.8 3.1 3 0 0 3 3 3 0 Inorganic H+ pyrophosphatase DUF1129 PF06570.11 EDO05973.1 - 2.6 7.5 25.2 0.13 11.8 2.3 4.3 3 2 1 4 4 4 0 Protein of unknown function (DUF1129) DUF5345 PF17280.2 EDO05973.1 - 4 7.5 14.2 37 4.4 0.1 5.1 4 0 0 4 4 4 0 Family of unknown function (DUF5345) Mito_carr PF00153.27 EDO05975.1 - 1.2e-41 140.6 3.0 8.2e-21 73.7 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein H2TH PF06831.14 EDO05976.1 - 0.19 11.7 0.0 0.33 11.0 0.0 1.7 1 1 0 1 1 1 0 Formamidopyrimidine-DNA glycosylase H2TH domain Peptidase_C1 PF00112.23 EDO05978.1 - 4.9e-27 95.4 12.8 5.5e-26 92.0 11.0 3.0 2 1 0 2 2 2 1 Papain family cysteine protease CathepsinC_exc PF08773.11 EDO05978.1 - 6.7e-13 49.0 0.0 1.6e-11 44.5 0.0 2.4 1 1 0 1 1 1 1 Cathepsin C exclusion domain Peptidase_C1_2 PF03051.15 EDO05978.1 - 0.28 9.9 1.9 0.28 9.9 0.6 1.5 2 0 0 2 2 2 0 Peptidase C1-like family AAA PF00004.29 EDO05980.1 - 2.1e-43 147.9 0.0 4.3e-43 146.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MIT PF04212.18 EDO05980.1 - 3.2e-15 55.9 1.7 7.6e-15 54.7 1.7 1.7 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 EDO05980.1 - 4.7e-07 29.5 0.0 1.1e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EDO05980.1 - 1.2e-06 29.0 0.3 0.00041 20.8 0.0 3.0 1 1 2 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EDO05980.1 - 3.8e-06 26.7 0.0 7.3e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EDO05980.1 - 9.3e-06 26.0 0.1 0.012 15.9 0.0 2.7 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EDO05980.1 - 2e-05 24.6 0.0 8.6e-05 22.6 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EDO05980.1 - 2.4e-05 24.5 0.0 4.6e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 EDO05980.1 - 3.7e-05 23.1 0.0 8.8e-05 21.9 0.0 1.4 1 1 1 2 2 2 1 TIP49 P-loop domain AAA_14 PF13173.6 EDO05980.1 - 8.5e-05 22.6 0.0 0.0002 21.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EDO05980.1 - 0.0004 20.2 0.0 0.00082 19.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDO05980.1 - 0.0014 18.8 0.0 0.004 17.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EDO05980.1 - 0.002 17.9 0.0 0.0038 17.0 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_7 PF12775.7 EDO05980.1 - 0.0034 16.9 0.0 0.0092 15.5 0.0 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_25 PF13481.6 EDO05980.1 - 0.0039 16.8 0.2 0.55 9.8 0.0 2.8 3 0 0 3 3 3 1 AAA domain DUF815 PF05673.13 EDO05980.1 - 0.004 16.4 0.0 0.0065 15.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 EDO05980.1 - 0.0049 17.2 0.0 0.018 15.4 0.0 2.1 2 0 0 2 2 2 1 RNA helicase AAA_18 PF13238.6 EDO05980.1 - 0.011 16.2 0.0 0.024 15.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EDO05980.1 - 0.017 14.6 0.1 0.035 13.6 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein Mg_chelatase PF01078.21 EDO05980.1 - 0.025 13.9 0.0 0.054 12.9 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase PF06745.13 EDO05980.1 - 0.029 13.7 0.0 0.45 9.8 0.0 2.3 1 1 1 2 2 2 0 KaiC TsaE PF02367.17 EDO05980.1 - 0.041 13.9 0.0 0.078 13.0 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_3 PF07726.11 EDO05980.1 - 0.055 13.3 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Bac_DnaA PF00308.18 EDO05980.1 - 0.058 13.2 0.0 0.26 11.1 0.0 1.9 1 1 0 1 1 1 0 Bacterial dnaA protein Parvo_NS1 PF01057.17 EDO05980.1 - 0.058 12.5 0.0 0.095 11.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ATPase_2 PF01637.18 EDO05980.1 - 0.064 13.2 0.0 0.9 9.4 0.0 2.3 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea AAA_17 PF13207.6 EDO05980.1 - 0.065 13.7 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EDO05980.1 - 0.066 13.1 0.2 0.53 10.2 0.0 2.4 2 1 0 3 3 2 0 NACHT domain TPR_12 PF13424.6 EDO05980.1 - 0.073 13.4 0.3 0.073 13.4 0.3 2.4 3 0 0 3 3 2 0 Tetratricopeptide repeat Sigma54_activat PF00158.26 EDO05980.1 - 0.088 12.5 0.0 0.25 11.0 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain Viral_Hsp90 PF03225.14 EDO05980.1 - 0.2 10.2 0.0 0.28 9.6 0.0 1.1 1 0 0 1 1 1 0 Viral heat shock protein Hsp90 homologue Pro_isomerase PF00160.21 EDO05981.1 - 1.2e-50 171.8 0.0 1.5e-50 171.6 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 EDO05982.1 - 6.6e-05 23.6 0.1 1.7 9.6 0.0 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat SET PF00856.28 EDO05982.1 - 0.0064 16.9 6.8 0.034 14.5 6.8 1.9 1 1 0 1 1 1 1 SET domain STT3 PF02516.14 EDO05983.1 - 5.8e-57 193.7 27.2 9e-57 193.1 27.2 1.2 1 0 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit DUF3413 PF11893.8 EDO05983.1 - 0.43 9.7 13.3 0.012 14.8 2.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3413) DUF676 PF05057.14 EDO05984.1 - 3.2e-15 56.2 0.0 4.2e-14 52.6 0.0 2.7 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 EDO05984.1 - 0.0021 17.9 0.0 0.017 15.0 0.0 2.3 1 1 0 1 1 1 1 Palmitoyl protein thioesterase PGI PF00342.19 EDO05985.1 - 1.9e-166 554.5 0.0 2.3e-166 554.2 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase CBF PF03914.17 EDO05987.1 - 2.4e-10 40.7 0.8 6.5e-10 39.3 0.8 1.7 1 0 0 1 1 1 1 CBF/Mak21 family NOG1 PF06858.14 EDO05988.1 - 1.1e-10 41.1 0.0 1e-09 38.0 0.0 2.6 2 0 0 2 2 2 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 EDO05988.1 - 6.7e-09 35.8 0.0 2.8e-07 30.6 0.0 2.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_14 PF13173.6 EDO05988.1 - 0.013 15.5 0.1 0.26 11.3 0.0 2.9 3 0 0 3 3 3 0 AAA domain NOG1_N PF17835.1 EDO05988.1 - 0.014 15.4 2.5 0.032 14.2 2.5 1.6 1 0 0 1 1 1 0 NOG1 N-terminal helical domain FeoB_N PF02421.18 EDO05988.1 - 0.024 14.2 0.2 0.11 12.1 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B T4_Rnl2_C PF18043.1 EDO05988.1 - 0.045 13.9 2.2 0.047 13.8 0.4 1.9 2 0 0 2 2 2 0 T4 RNA ligase 2 C-terminal COG4 PF08318.12 EDO05989.1 - 3.7e-17 62.4 0.1 8.7e-17 61.2 0.1 1.6 1 0 0 1 1 1 1 COG4 transport protein MBOAT_2 PF13813.6 EDO05989.1 - 0.41 11.0 2.5 14 6.0 0.3 3.3 3 0 0 3 3 3 0 Membrane bound O-acyl transferase family RabGAP-TBC PF00566.18 EDO05991.1 - 1.6e-51 175.1 8.0 1.9e-51 174.8 8.0 1.0 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF2129 PF09902.9 EDO05991.1 - 0.96 9.6 4.0 2.1 8.5 0.8 2.3 1 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2129) Glyco_transf_20 PF00982.21 EDO05992.1 - 1.5e-101 340.5 0.0 1.8e-101 340.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EDO05992.1 - 9.3e-36 123.1 0.0 2.3e-35 121.8 0.0 1.6 1 0 0 1 1 1 1 Trehalose-phosphatase CBM_20 PF00686.19 EDO05992.1 - 9.4e-13 47.9 0.0 2.2e-12 46.7 0.0 1.6 1 0 0 1 1 1 1 Starch binding domain Hydrolase_3 PF08282.12 EDO05992.1 - 0.18 11.5 0.0 0.35 10.6 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase NTP_transferase PF00483.23 EDO05994.1 - 2e-13 50.5 0.1 9.3e-13 48.3 0.0 1.8 2 0 0 2 2 2 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 EDO05994.1 - 0.00013 22.3 0.0 0.00021 21.7 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 EDO05994.1 - 0.0039 17.0 0.0 0.0066 16.2 0.0 1.3 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Hexapep PF00132.24 EDO05994.1 - 0.017 14.8 0.1 0.059 13.1 0.0 2.0 2 0 0 2 2 2 0 Bacterial transferase hexapeptide (six repeats) MP PF01107.18 EDO05994.1 - 0.039 13.5 0.1 0.074 12.6 0.1 1.4 1 0 0 1 1 1 0 Viral movement protein (MP) RRM_1 PF00076.22 EDO05995.1 - 8.6e-12 44.7 0.1 5.6e-05 22.9 0.0 2.6 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SWIRM-assoc_2 PF16496.5 EDO05995.1 - 2.2 7.1 10.2 3.3 6.5 10.2 1.3 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Topoisom_bac PF01131.20 EDO05996.1 - 1.5e-100 337.1 0.0 2e-100 336.7 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 EDO05996.1 - 8.5e-14 51.6 0.0 1.9e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Toprim domain Ribosomal_S27e PF01667.17 EDO05996.1 - 0.03 14.0 0.2 0.03 14.0 0.2 3.0 3 0 0 3 3 3 0 Ribosomal protein S27 Toprim_4 PF13662.6 EDO05996.1 - 0.062 13.8 0.0 0.15 12.6 0.0 1.6 1 0 0 1 1 1 0 Toprim domain Fer4_11 PF13247.6 EDO05996.1 - 0.075 13.2 1.0 0.28 11.3 1.0 2.1 1 0 0 1 1 1 0 4Fe-4S dicluster domain RNA_pol_N PF01194.17 EDO05996.1 - 0.11 12.8 0.0 0.11 12.8 0.0 3.1 4 0 0 4 4 4 0 RNA polymerases N / 8 kDa subunit HypA PF01155.19 EDO05996.1 - 0.53 10.3 6.7 4.2 7.4 1.1 2.9 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA VESA1_N PF12785.7 EDO05997.1 - 5.3e-231 767.4 19.8 5.3e-231 767.4 19.8 2.9 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 Baculo_PEP_C PF04513.12 EDO05997.1 - 0.6 10.1 2.4 2.9 7.9 0.0 3.0 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus VESA1_N PF12785.7 EDO05998.1 - 4.3e-22 78.7 10.0 1.1e-11 44.4 8.5 4.6 2 2 2 4 4 4 3 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO05999.1 - 2.6e-212 705.8 23.5 2.6e-212 705.8 23.5 2.5 4 0 0 4 4 4 1 Variant erythrocyte surface antigen-1 DDE_Tnp_1_assoc PF13808.6 EDO05999.1 - 0.0055 16.7 0.0 0.018 15.1 0.0 1.9 1 0 0 1 1 1 1 DDE_Tnp_1-associated MnmE_helical PF12631.7 EDO05999.1 - 0.0098 16.1 0.2 0.16 12.1 0.4 2.4 2 0 0 2 2 2 1 MnmE helical domain RsbRD_N PF14361.6 EDO05999.1 - 0.41 11.3 4.4 20 5.9 0.0 3.9 4 0 0 4 4 4 0 RsbT co-antagonist protein rsbRD N-terminal domain FliJ PF02050.16 EDO05999.1 - 1.5 9.0 6.6 36 4.6 0.0 3.8 3 1 1 4 4 4 0 Flagellar FliJ protein Baculo_PEP_C PF04513.12 EDO05999.1 - 3.4 7.7 6.2 3.7 7.6 0.4 2.9 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus F-box-like_2 PF13013.6 EDO06000.1 - 6.3e-11 42.2 0.2 9.6e-05 22.3 0.0 2.2 2 0 0 2 2 2 2 F-box-like domain R3H PF01424.22 EDO06000.1 - 0.047 13.7 0.2 14 5.8 0.0 2.3 2 0 0 2 2 2 0 R3H domain Prok-RING_4 PF14447.6 EDO06002.1 - 9.2e-09 35.0 4.0 2.2e-07 30.6 1.5 2.4 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EDO06002.1 - 1.8e-08 34.2 6.7 4.3e-08 33.0 6.7 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EDO06002.1 - 1.1e-07 32.1 7.0 3.6e-07 30.4 7.0 2.0 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EDO06002.1 - 2.4e-07 30.5 10.5 2.2e-06 27.4 10.6 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDO06002.1 - 2.1e-06 27.5 5.4 1.2e-05 25.0 2.3 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDO06002.1 - 2.8e-06 27.3 2.3 1e-05 25.4 2.3 2.0 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EDO06002.1 - 1.3e-05 24.9 6.7 3.3e-05 23.7 6.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EDO06002.1 - 2.4e-05 24.5 4.0 6.8e-05 23.1 4.0 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EDO06002.1 - 0.017 15.2 3.7 0.017 15.2 3.7 2.5 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Rtf2 PF04641.12 EDO06002.1 - 0.043 13.2 0.4 0.065 12.6 0.4 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger zf-RING_4 PF14570.6 EDO06002.1 - 0.15 11.9 9.7 0.93 9.3 9.8 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 EDO06002.1 - 0.34 10.7 4.4 1.2 8.9 1.8 2.8 2 1 0 2 2 2 0 RING-like zinc finger zinc-ribbons_6 PF07191.12 EDO06002.1 - 0.35 10.9 4.3 1.1 9.3 4.3 1.8 1 1 0 1 1 1 0 zinc-ribbons zf-ANAPC11 PF12861.7 EDO06002.1 - 0.67 10.0 4.2 1.2 9.2 1.4 2.6 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-H2C2_2 PF13465.6 EDO06002.1 - 2.8 8.5 5.0 16 6.1 1.9 2.5 2 0 0 2 2 2 0 Zinc-finger double domain SURF1 PF02104.15 EDO06003.1 - 4.9e-28 98.5 0.0 7.9e-28 97.9 0.0 1.3 1 0 0 1 1 1 1 SURF1 family RabGAP-TBC PF00566.18 EDO06004.1 - 0.00012 21.9 0.1 0.00023 20.9 0.1 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Xol-1_GHMP-like PF09109.10 EDO06005.1 - 0.068 13.0 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 Switch protein XOL-1, GHMP-like Rrf2 PF02082.20 EDO06005.1 - 0.12 12.8 0.1 0.22 11.9 0.1 1.4 1 0 0 1 1 1 0 Transcriptional regulator zf-C2H2_jaz PF12171.8 EDO06006.1 - 9.3e-07 29.0 2.6 2.2e-06 27.8 2.6 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding AKAP95 PF04988.12 EDO06006.1 - 0.00043 20.5 2.0 0.00049 20.4 1.3 1.3 1 1 0 1 1 1 1 A-kinase anchoring protein 95 (AKAP95) zf-met PF12874.7 EDO06006.1 - 0.0054 17.1 1.8 0.01 16.2 1.8 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type SPASM PF13186.6 EDO06006.1 - 0.0096 16.4 0.1 0.43 11.1 0.0 2.3 1 1 1 2 2 2 2 Iron-sulfur cluster-binding domain zf-C2H2_2 PF12756.7 EDO06006.1 - 0.011 16.0 0.8 0.015 15.7 0.8 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) OrsD PF12013.8 EDO06006.1 - 0.017 15.6 0.1 0.025 15.0 0.1 1.3 1 0 0 1 1 1 0 Orsellinic acid/F9775 biosynthesis cluster protein D Plectin PF00681.20 EDO06007.1 - 0.001 18.9 0.0 0.0021 17.9 0.0 1.5 1 0 0 1 1 1 1 Plectin repeat SurA_N_2 PF13623.6 EDO06007.1 - 0.049 13.5 5.1 0.062 13.2 0.0 2.3 2 0 0 2 2 2 0 SurA N-terminal domain ASC PF00858.24 EDO06007.1 - 0.073 12.0 1.5 0.083 11.8 1.5 1.1 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel Nop25 PF09805.9 EDO06007.1 - 0.23 11.9 23.6 9.9 6.6 21.8 2.1 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) EF-hand_7 PF13499.6 EDO06008.1 - 1.4e-07 31.9 0.4 0.0004 20.8 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EDO06008.1 - 9.4e-06 25.4 0.2 0.087 12.7 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair DUF2624 PF11116.8 EDO06008.1 - 0.00098 20.0 0.3 0.00098 20.0 0.3 2.6 3 1 0 3 3 3 1 Protein of unknown function (DUF2624) EF-hand_6 PF13405.6 EDO06008.1 - 0.012 15.4 1.7 5.9 7.1 0.0 4.2 4 1 0 4 4 4 0 EF-hand domain Caleosin PF05042.13 EDO06008.1 - 0.017 15.0 1.0 0.83 9.6 0.1 2.3 1 1 1 2 2 2 0 Caleosin related protein NADPH_Ox PF08414.10 EDO06008.1 - 0.049 14.0 0.3 0.17 12.2 0.0 2.0 3 0 0 3 3 3 0 Respiratory burst NADPH oxidase DUF4362 PF14275.6 EDO06008.1 - 0.073 13.4 1.7 0.14 12.4 1.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4362) STAS PF01740.21 EDO06008.1 - 0.074 12.7 1.0 0.28 10.8 0.9 1.8 1 1 0 1 1 1 0 STAS domain SelB-wing_1 PF09105.10 EDO06008.1 - 0.088 12.8 0.1 5.7 7.0 0.0 2.9 3 0 0 3 3 3 0 Elongation factor SelB, winged helix Lip_prot_lig_C PF10437.9 EDO06008.1 - 0.13 12.3 1.7 1.6 8.7 0.1 2.9 3 1 0 3 3 3 0 Bacterial lipoate protein ligase C-terminus zf-Tim10_DDP PF02953.15 EDO06009.1 - 7.6e-10 38.3 1.2 9.2e-10 38.0 1.2 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger CDtoxinA PF03498.14 EDO06009.1 - 0.014 15.0 0.2 0.015 14.9 0.2 1.1 1 0 0 1 1 1 0 Cytolethal distending toxin A/C domain c-SKI_SMAD_bind PF08782.10 EDO06009.1 - 0.073 13.3 0.4 0.1 12.9 0.4 1.3 1 0 0 1 1 1 0 c-SKI Smad4 binding domain XPG_I PF00867.18 EDO06010.1 - 5.1e-25 87.7 0.0 1.3e-24 86.4 0.0 1.8 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 EDO06010.1 - 1.9e-15 57.1 0.0 4e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 EDO06010.1 - 0.023 14.2 0.0 0.042 13.3 0.0 1.3 1 0 0 1 1 1 0 XPG domain containing 5_3_exonuc PF01367.20 EDO06010.1 - 0.025 15.2 0.0 0.094 13.3 0.0 2.0 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold Pox_G5 PF04599.12 EDO06010.1 - 0.042 12.9 0.0 0.073 12.1 0.0 1.3 1 0 0 1 1 1 0 Poxvirus G5 protein Herpes_LMP1 PF05297.11 EDO06010.1 - 0.62 9.2 2.8 0.96 8.6 2.8 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) TFIIS_C PF01096.18 EDO06011.1 - 1.6e-20 72.6 4.0 1.6e-20 72.6 4.0 3.1 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS) Zn_Tnp_IS1595 PF12760.7 EDO06011.1 - 7.3e-05 22.7 1.1 7.3e-05 22.7 1.1 2.4 2 0 0 2 2 2 1 Transposase zinc-ribbon domain TF_Zn_Ribbon PF08271.12 EDO06011.1 - 0.005 16.3 9.9 0.051 13.1 0.7 2.4 2 0 0 2 2 2 2 TFIIB zinc-binding zf-Dof PF02701.15 EDO06011.1 - 0.044 13.9 1.2 0.044 13.9 1.2 2.5 2 1 0 2 2 2 0 Dof domain, zinc finger PhnA_Zn_Ribbon PF08274.12 EDO06011.1 - 0.098 12.6 7.0 0.59 10.1 0.6 3.3 3 1 1 4 4 4 0 PhnA Zinc-Ribbon HNH PF01844.23 EDO06011.1 - 0.33 11.1 0.1 0.33 11.1 0.1 2.9 3 0 0 3 3 3 0 HNH endonuclease Zn_Tnp_IS1 PF03811.13 EDO06011.1 - 0.77 9.5 7.5 3.9 7.3 0.1 3.7 4 0 0 4 4 4 0 InsA N-terminal domain zinc_ribbon_10 PF10058.9 EDO06011.1 - 4 7.2 12.8 8.4 6.2 2.5 2.6 2 1 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Kelch_3 PF13415.6 EDO06012.1 - 1.2e-13 51.0 0.2 9.1e-08 32.2 0.0 3.4 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_4 PF13418.6 EDO06012.1 - 1.1e-11 44.6 2.6 0.0082 16.1 0.3 3.7 3 1 0 3 3 3 3 Galactose oxidase, central domain Kelch_6 PF13964.6 EDO06012.1 - 5.4e-09 36.0 0.1 0.015 15.6 0.0 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 EDO06012.1 - 2.8e-07 30.4 2.4 0.19 11.8 0.0 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.25 EDO06012.1 - 0.00016 21.2 0.2 0.79 9.4 0.0 2.8 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 EDO06012.1 - 0.13 12.3 0.6 39 4.4 0.0 3.3 3 0 0 3 3 3 0 Kelch motif LIN52 PF10044.9 EDO06014.1 - 0.089 13.5 0.4 1.2 9.8 0.1 2.4 2 0 0 2 2 2 0 Retinal tissue protein AdoHcyase_NAD PF00670.21 EDO06014.1 - 0.12 12.4 0.1 0.22 11.6 0.1 1.3 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Mannosyl_trans PF05007.13 EDO06015.1 - 7.7e-61 206.2 27.1 1.1e-60 205.7 27.1 1.2 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 EDO06015.1 - 8e-07 28.4 26.4 2e-06 27.1 24.7 2.4 1 1 0 1 1 1 1 GPI transamidase subunit PIG-U GT87 PF09594.10 EDO06015.1 - 0.0013 18.5 8.3 0.0013 18.5 8.3 2.6 2 1 0 3 3 3 1 Glycosyltransferase family 87 DHR10 PF18595.1 EDO06016.1 - 0.0027 17.8 5.4 0.0027 17.8 5.4 2.5 1 1 1 2 2 2 1 Designed helical repeat protein 10 domain Sec8_exocyst PF04048.14 EDO06016.1 - 0.039 13.9 3.4 0.036 14.0 1.1 2.1 2 1 0 2 2 2 0 Sec8 exocyst complex component specific domain Snapin_Pallidin PF14712.6 EDO06016.1 - 0.045 14.2 3.0 0.2 12.1 3.0 2.1 1 0 0 1 1 1 0 Snapin/Pallidin APG17 PF04108.12 EDO06016.1 - 0.095 11.8 8.2 0.031 13.4 2.7 2.5 1 1 2 3 3 3 0 Autophagy protein Apg17 BLOC1_2 PF10046.9 EDO06016.1 - 3.8 7.9 7.0 21 5.5 0.6 3.2 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 RRF PF01765.19 EDO06018.1 - 7.5e-07 29.2 0.7 1.2e-06 28.6 0.6 1.4 1 1 0 1 1 1 1 Ribosome recycling factor DUF1658 PF07871.11 EDO06019.1 - 0.49 10.4 3.6 13 5.9 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1658) zf-UBR PF02207.20 EDO06020.1 - 1e-14 54.4 14.5 1e-14 54.4 14.5 2.6 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) Pkinase PF00069.25 EDO06021.1 - 1.9e-74 250.4 0.1 3.3e-74 249.6 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO06021.1 - 4.9e-36 124.4 0.0 1e-35 123.3 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 EDO06021.1 - 5.8e-14 52.5 0.1 1.7e-13 50.9 0.1 1.9 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 EDO06021.1 - 8.3e-11 41.7 0.0 1e-09 38.1 0.0 2.1 2 0 0 2 2 2 1 Kinase-like EF-hand_6 PF13405.6 EDO06021.1 - 7.4e-10 38.0 0.7 0.0041 16.9 0.0 4.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 EDO06021.1 - 3.4e-08 32.5 3.5 0.0067 15.9 0.2 4.1 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 EDO06021.1 - 6.6e-07 29.7 3.1 0.13 12.8 0.2 4.4 4 0 0 4 4 4 2 EF-hand domain pair Pkinase_fungal PF17667.1 EDO06021.1 - 6.2e-06 25.2 0.0 4.3e-05 22.5 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EDO06021.1 - 8.2e-06 25.3 0.2 1.7e-05 24.3 0.2 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EDO06021.1 - 0.00063 19.4 0.7 0.0023 17.6 0.7 1.9 1 1 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.9 EDO06021.1 - 0.0012 18.4 0.0 0.029 13.9 0.0 2.4 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL zf-CRD PF17979.1 EDO06021.1 - 0.0013 18.9 0.1 0.004 17.3 0.1 1.9 1 0 0 1 1 1 1 Cysteine rich domain with multizinc binding regions FTA2 PF13095.6 EDO06021.1 - 0.013 15.2 0.4 0.13 11.9 0.0 2.4 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pox_ser-thr_kin PF05445.11 EDO06021.1 - 0.014 14.4 0.2 0.024 13.6 0.2 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase EF-hand_5 PF13202.6 EDO06021.1 - 0.021 14.3 1.6 1.3 8.6 0.0 2.9 2 0 0 2 2 2 0 EF hand EF-hand_8 PF13833.6 EDO06021.1 - 0.024 14.5 6.0 0.56 10.1 0.1 3.4 2 1 1 3 3 3 0 EF-hand domain pair PH_11 PF15413.6 EDO06021.1 - 0.028 14.8 2.1 0.54 10.7 1.2 2.8 2 0 0 2 2 2 0 Pleckstrin homology domain APH PF01636.23 EDO06021.1 - 0.028 14.3 0.0 5.1 7.0 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family PH_8 PF15409.6 EDO06021.1 - 0.035 14.4 1.4 0.32 11.3 1.1 2.6 2 0 0 2 2 2 0 Pleckstrin homology domain LRR_4 PF12799.7 EDO06022.1 - 1.3e-06 28.6 4.3 0.047 14.1 1.0 4.8 2 1 3 5 5 5 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EDO06022.1 - 1.9e-06 27.4 3.7 3.7 7.8 0.1 6.0 6 0 0 6 6 6 2 Leucine Rich repeat LRR_1 PF00560.33 EDO06022.1 - 0.0029 17.9 7.6 21 6.1 0.3 5.8 5 1 0 5 5 5 2 Leucine Rich Repeat LRR_8 PF13855.6 EDO06022.1 - 0.011 15.4 4.5 0.13 12.0 1.1 3.7 3 2 0 3 3 3 0 Leucine rich repeat LRR_9 PF14580.6 EDO06022.1 - 0.014 14.9 0.0 0.028 13.9 0.0 1.4 1 1 0 1 1 1 0 Leucine-rich repeat zf-C3HC4_2 PF13923.6 EDO06023.1 - 9.3e-11 41.4 8.9 2e-10 40.3 8.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDO06023.1 - 2e-09 37.3 5.5 2.9e-09 36.8 3.9 2.1 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EDO06023.1 - 8.7e-09 35.2 8.5 2.3e-08 33.8 8.5 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EDO06023.1 - 9.2e-09 35.3 9.8 9.2e-09 35.3 9.8 2.0 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EDO06023.1 - 1.6e-08 34.3 6.2 3e-08 33.4 6.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDO06023.1 - 6.3e-08 32.8 7.4 1.6e-07 31.5 7.4 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EDO06023.1 - 2e-07 30.7 8.6 5.1e-07 29.5 8.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDO06023.1 - 2.9e-07 30.2 6.9 1.2e-06 28.3 7.0 1.9 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 EDO06023.1 - 2.1e-06 27.8 4.6 5.6e-06 26.4 4.6 1.7 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-rbx1 PF12678.7 EDO06023.1 - 0.00073 19.8 7.4 0.0028 17.9 7.4 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain U-box PF04564.15 EDO06023.1 - 0.0057 16.8 0.0 0.014 15.5 0.0 1.7 1 0 0 1 1 1 1 U-box domain zf-RING_6 PF14835.6 EDO06023.1 - 0.022 14.6 2.9 0.054 13.4 2.9 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 EDO06023.1 - 0.49 10.5 4.9 0.26 11.4 1.5 2.3 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.8 EDO06023.1 - 0.86 9.5 7.5 1.1 9.1 5.7 2.1 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit Zn-C2H2_12 PF18112.1 EDO06023.1 - 2.1 8.9 5.1 9.8 6.7 0.1 3.2 3 0 0 3 3 2 0 Autophagy receptor zinc finger-C2H2 domain GTP_EFTU PF00009.27 EDO06024.1 - 1e-43 149.1 0.0 1.3e-43 148.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EDO06024.1 - 6.8e-26 90.8 1.3 1.4e-25 89.7 0.2 2.2 3 0 0 3 3 3 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EDO06024.1 - 3.3e-07 30.6 0.3 9.9e-07 29.1 0.3 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDO06024.1 - 0.0022 18.1 0.1 0.013 15.6 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase PAM2 PF07145.15 EDO06024.1 - 0.063 13.0 2.3 0.23 11.3 0.2 2.8 2 0 0 2 2 2 0 Ataxin-2 C-terminal region Ribosomal_L37 PF08561.10 EDO06025.1 - 0.00015 22.3 6.7 0.0024 18.4 1.5 2.3 1 1 0 2 2 2 2 Mitochondrial ribosomal protein L37 RAP PF08373.10 EDO06026.1 - 2.8e-13 49.7 0.3 2.8e-13 49.7 0.3 2.2 3 0 0 3 3 3 1 RAP domain MTES_1575 PF18741.1 EDO06026.1 - 0.012 15.7 0.0 0.03 14.5 0.0 1.7 1 0 0 1 1 1 0 REase_MTES_1575 DUF1411 PF07199.11 EDO06027.1 - 0.014 15.1 0.3 0.014 15.1 0.3 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1411) DUF1411 PF07199.11 EDO06029.1 - 0.014 15.1 0.1 0.027 14.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1411) NPV_P10 PF05531.12 EDO06029.1 - 0.022 15.2 0.1 0.073 13.5 0.0 1.9 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein CPSF100_C PF13299.6 EDO06029.1 - 0.048 13.8 0.3 0.09 13.0 0.1 1.5 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal TMCO5 PF14992.6 EDO06029.1 - 0.38 10.3 4.5 0.7 9.4 4.2 1.6 1 1 0 1 1 1 0 TMCO5 family Med21 PF11221.8 EDO06029.1 - 3.6 7.8 8.2 30 4.8 8.2 2.2 1 1 0 1 1 1 0 Subunit 21 of Mediator complex DUF1411 PF07199.11 EDO06031.1 - 0.0016 18.2 0.5 0.0047 16.6 0.1 1.9 2 1 0 2 2 2 1 Protein of unknown function (DUF1411) Spore_III_AB PF09548.10 EDO06031.1 - 0.0017 18.5 0.7 1.3 9.2 0.0 2.2 2 0 0 2 2 2 2 Stage III sporulation protein AB (spore_III_AB) DUF2281 PF10047.9 EDO06031.1 - 0.018 15.7 5.5 0.13 12.9 1.8 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2281) MukF_M PF17192.4 EDO06031.1 - 0.026 14.3 1.9 0.092 12.5 1.9 1.9 1 1 0 1 1 1 0 MukF middle domain DUF4698 PF15769.5 EDO06031.1 - 0.095 11.7 3.4 2.7 6.9 0.0 2.7 1 1 1 3 3 3 0 Domain of unknown function (DUF4698) DUF2617 PF10936.8 EDO06031.1 - 0.12 12.4 0.4 8.7 6.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF2617 MinE PF03776.14 EDO06031.1 - 0.37 10.8 5.9 3.8 7.6 0.1 2.9 2 1 0 3 3 3 0 Septum formation topological specificity factor MinE SMN PF06003.12 EDO06031.1 - 0.98 8.6 9.1 2 7.6 9.1 1.5 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Xpo1 PF08389.12 EDO06031.1 - 1 9.4 4.8 1.9 8.5 1.0 2.3 2 1 0 2 2 2 0 Exportin 1-like protein RRF PF01765.19 EDO06031.1 - 2 8.3 9.4 0.34 10.9 4.2 2.2 2 1 0 2 2 2 0 Ribosome recycling factor DUF1411 PF07199.11 EDO06033.1 - 0.13 11.9 2.6 0.14 11.8 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1411) Myb_DNA-binding PF00249.31 EDO06035.1 - 1.1e-09 38.3 0.2 0.00039 20.5 0.1 3.0 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDO06035.1 - 0.00027 21.1 4.3 0.0085 16.3 0.9 3.0 2 0 0 2 2 2 2 Myb-like DNA-binding domain She9_MDM33 PF05546.11 EDO06035.1 - 0.3 10.9 5.3 0.051 13.4 0.8 1.9 2 0 0 2 2 2 0 She9 / Mdm33 family Pkinase PF00069.25 EDO06036.1 - 1.2e-29 103.5 0.0 2.8e-29 102.3 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO06036.1 - 2.9e-24 85.8 0.0 6.4e-24 84.6 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO06036.1 - 0.0039 16.5 0.2 0.05 12.9 0.0 2.8 2 1 0 3 3 3 1 Kinase-like Desmo_N PF06771.11 EDO06036.1 - 0.045 14.1 0.0 0.22 11.9 0.0 2.2 1 0 0 1 1 1 0 Viral Desmoplakin N-terminus BTAD PF03704.17 EDO06036.1 - 0.065 13.7 0.0 0.21 12.0 0.0 1.8 1 0 0 1 1 1 0 Bacterial transcriptional activator domain T3SchapCesA PF11439.8 EDO06036.1 - 0.065 13.4 0.6 0.23 11.6 0.6 1.9 1 0 0 1 1 1 0 Type III secretion system filament chaperone CesA FNIP_M PF14637.6 EDO06036.1 - 0.07 13.1 0.6 0.15 12.1 0.6 1.5 1 0 0 1 1 1 0 Folliculin-interacting protein middle domain TM_helix PF05552.12 EDO06037.1 - 0.058 13.4 0.3 0.097 12.7 0.3 1.4 1 0 0 1 1 1 0 Conserved TM helix DUF4131 PF13567.6 EDO06037.1 - 0.063 12.9 0.0 0.35 10.5 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Thymidylat_synt PF00303.19 EDO06038.1 - 3.1e-108 361.0 0.0 4e-108 360.6 0.0 1.1 1 0 0 1 1 1 1 Thymidylate synthase DHFR_1 PF00186.19 EDO06038.1 - 2.7e-29 102.0 0.0 1.3e-28 99.8 0.0 1.9 1 1 0 1 1 1 1 Dihydrofolate reductase MreB_Mbl PF06723.13 EDO06038.1 - 0.083 11.7 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 MreB/Mbl protein RibD_C PF01872.17 EDO06038.1 - 0.089 12.6 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 RibD C-terminal domain AMP-binding PF00501.28 EDO06040.1 - 1.5e-05 23.8 0.0 0.00061 18.5 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme RQC PF09382.10 EDO06041.1 - 2.9e-20 72.2 0.0 6.3e-20 71.1 0.0 1.6 1 0 0 1 1 1 1 RQC domain DEAD PF00270.29 EDO06041.1 - 5.1e-17 62.2 0.0 1e-16 61.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO06041.1 - 4.6e-14 52.7 0.0 5e-13 49.4 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 EDO06041.1 - 5.7e-11 43.0 2.0 5.7e-11 43.0 2.0 3.7 3 0 0 3 3 3 1 RecQ zinc-binding ResIII PF04851.15 EDO06041.1 - 5.2e-07 29.8 0.0 1.2e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SMC_N PF02463.19 EDO06042.1 - 3.4e-15 56.1 6.3 2.5e-07 30.4 3.8 3.4 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EDO06042.1 - 5.7e-11 43.3 1.4 5.7e-11 43.3 1.4 3.8 2 2 0 2 2 2 1 AAA domain AAA_21 PF13304.6 EDO06042.1 - 0.00021 21.2 4.4 0.17 11.7 0.2 2.6 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EDO06042.1 - 0.038 13.7 0.0 0.096 12.4 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ERp29 PF07749.12 EDO06042.1 - 3.5 8.6 6.2 2.6 9.0 2.5 2.7 2 0 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain CDC45 PF02724.14 EDO06043.1 - 0.0027 16.1 5.9 0.0031 15.9 5.9 1.1 1 0 0 1 1 1 1 CDC45-like protein Nop14 PF04147.12 EDO06043.1 - 0.0084 14.4 17.1 0.012 13.9 17.1 1.1 1 0 0 1 1 1 1 Nop14-like family PH PF00169.29 EDO06043.1 - 0.033 14.7 0.0 0.082 13.4 0.0 1.6 1 0 0 1 1 1 0 PH domain SDA1 PF05285.12 EDO06043.1 - 0.082 12.3 18.2 0.11 11.8 18.2 1.2 1 0 0 1 1 1 0 SDA1 RNA_pol_Rpc4 PF05132.14 EDO06043.1 - 0.23 11.9 2.7 0.42 11.0 2.7 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 Zip PF02535.22 EDO06043.1 - 2.2 7.4 7.0 2.8 7.0 7.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Drc1-Sld2 PF11719.8 EDO06043.1 - 3.2 7.2 16.5 4.6 6.7 16.5 1.2 1 0 0 1 1 1 0 DNA replication and checkpoint protein NOA36 PF06524.12 EDO06043.1 - 3.3 7.0 16.7 5.5 6.2 16.7 1.3 1 0 0 1 1 1 0 NOA36 protein Presenilin PF01080.17 EDO06043.1 - 3.4 6.3 5.3 4.3 6.0 5.3 1.1 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 EDO06043.1 - 3.4 6.5 6.2 1.1 8.1 3.4 1.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DNA_pol_phi PF04931.13 EDO06043.1 - 5.7 4.9 21.4 8.8 4.3 21.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi Kri1_C PF12936.7 EDO06045.1 - 1.1e-19 70.4 1.8 1.1e-19 70.4 1.8 3.4 3 0 0 3 3 3 1 KRI1-like family C-terminal Kri1 PF05178.12 EDO06045.1 - 3.1e-14 53.4 3.6 3.1e-14 53.4 3.6 3.9 4 1 2 6 6 6 1 KRI1-like family ZZ PF00569.17 EDO06045.1 - 0.28 11.0 6.3 0.98 9.3 6.3 2.0 1 0 0 1 1 1 0 Zinc finger, ZZ type Peptidase_M41 PF01434.18 EDO06047.1 - 3.3e-51 173.9 1.0 4.9e-51 173.3 1.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EDO06047.1 - 9.9e-43 145.7 0.0 2.7e-42 144.3 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO06047.1 - 8.4e-08 31.9 0.1 2.4e-07 30.5 0.1 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EDO06047.1 - 8.1e-06 26.3 0.5 0.0013 19.1 0.1 2.8 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EDO06047.1 - 3.8e-05 23.5 0.0 0.00012 21.8 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EDO06047.1 - 6.3e-05 22.3 0.3 0.00019 20.7 0.0 1.8 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_22 PF13401.6 EDO06047.1 - 0.0028 17.9 1.4 0.13 12.5 0.0 3.2 2 1 0 3 3 3 1 AAA domain AAA_28 PF13521.6 EDO06047.1 - 0.003 17.8 0.0 0.016 15.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 EDO06047.1 - 0.0055 16.7 0.0 0.013 15.5 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 EDO06047.1 - 0.008 16.2 0.1 0.032 14.2 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EDO06047.1 - 0.0098 15.6 0.1 0.027 14.2 0.0 1.7 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_18 PF13238.6 EDO06047.1 - 0.021 15.4 0.1 0.069 13.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EDO06047.1 - 0.022 14.9 0.1 0.19 11.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EDO06047.1 - 0.023 14.1 0.2 0.052 12.9 0.2 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_2 PF07724.14 EDO06047.1 - 0.028 14.5 0.0 0.074 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) GCP_C_terminal PF04130.13 EDO06047.1 - 0.065 12.7 0.4 1.3 8.4 0.0 2.4 3 0 0 3 3 3 0 Gamma tubulin complex component C-terminal AAA_24 PF13479.6 EDO06047.1 - 0.076 12.7 0.1 2.4 7.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EDO06047.1 - 0.082 12.2 0.1 0.2 10.9 0.1 1.6 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.12 EDO06047.1 - 0.097 12.6 0.1 0.76 9.7 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.6 EDO06047.1 - 0.12 12.0 0.4 2.4 7.7 0.2 2.3 1 1 1 2 2 2 0 AAA domain DUF3461 PF11944.8 EDO06047.1 - 1.1 9.4 3.5 3 8.0 0.5 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3461) Ribosomal_L6e PF01159.19 EDO06048.1 - 1.2e-27 96.7 0.2 1.5e-27 96.3 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L6e EF1G PF00647.19 EDO06049.1 - 2.7e-30 104.6 1.7 5.3e-30 103.6 1.1 1.8 2 0 0 2 2 2 1 Elongation factor 1 gamma, conserved domain GST_C_3 PF14497.6 EDO06049.1 - 0.0011 19.1 0.0 0.0023 18.1 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EDO06049.1 - 0.017 15.1 0.0 0.11 12.5 0.0 2.3 3 0 0 3 3 3 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EDO06049.1 - 0.017 15.3 0.0 0.039 14.2 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain VESA1_N PF12785.7 EDO06050.1 - 2.4e-225 748.7 23.2 2.4e-225 748.7 23.2 2.8 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 DUF148 PF02520.17 EDO06050.1 - 0.051 13.7 4.6 0.08 13.1 0.7 2.7 2 0 0 2 2 2 0 Domain of unknown function DUF148 ApoLp-III PF07464.11 EDO06050.1 - 2.8 8.0 10.6 9.7 6.3 1.9 3.2 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Cauli_DNA-bind PF03310.13 EDO06050.1 - 5.2 7.1 8.3 0.76 9.8 2.9 2.4 2 0 0 2 2 2 0 Caulimovirus DNA-binding protein VESA1_N PF12785.7 EDO06051.1 - 4.6e-17 62.1 8.6 8.7e-10 38.1 0.1 5.0 4 2 1 5 5 5 3 Variant erythrocyte surface antigen-1 DUF5638 PF18688.1 EDO06051.1 - 0.065 13.5 0.0 0.29 11.5 0.1 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5638) MFS_1 PF07690.16 EDO06053.1 - 6.5e-17 61.5 17.9 6.5e-17 61.5 17.9 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily VESA1_N PF12785.7 EDO06054.1 - 2.2e-37 129.1 0.7 3.3e-37 128.5 0.7 1.2 1 0 0 1 1 1 1 Variant erythrocyte surface antigen-1 SprT-like PF10263.9 EDO06055.1 - 3.3e-23 81.7 0.3 1.1e-22 80.0 0.3 1.7 1 1 0 1 1 1 1 SprT-like family Peptidase_M76 PF09768.9 EDO06055.1 - 0.012 15.4 0.1 0.016 15.0 0.1 1.3 1 0 0 1 1 1 0 Peptidase M76 family DUF2258 PF10015.9 EDO06055.1 - 0.033 14.3 0.0 0.048 13.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2258) DUF4368 PF14287.6 EDO06055.1 - 0.1 12.9 0.2 5.6 7.3 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4368) Peptidase_M91 PF14891.6 EDO06055.1 - 0.12 12.7 0.0 0.12 12.7 0.0 1.2 1 0 0 1 1 1 0 Effector protein zf-rbx1 PF12678.7 EDO06056.1 - 0.096 13.0 4.3 0.18 12.1 3.3 2.0 1 1 1 2 2 2 0 RING-H2 zinc finger domain DUF150_C PF17384.2 EDO06057.1 - 0.011 15.8 0.0 0.02 15.0 0.0 1.4 1 0 0 1 1 1 0 RimP C-terminal SH3 domain WD40 PF00400.32 EDO06060.1 - 1.3e-26 92.3 42.9 6.7e-07 29.9 0.4 11.9 12 1 0 12 12 12 7 WD domain, G-beta repeat Utp12 PF04003.12 EDO06060.1 - 5.6e-18 65.2 0.1 1e-17 64.4 0.1 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EDO06060.1 - 4e-12 46.3 0.1 0.27 11.6 0.0 8.0 6 2 2 8 8 8 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDO06060.1 - 3.5e-05 22.9 0.2 0.16 10.9 0.0 5.4 6 1 0 6 6 6 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EDO06060.1 - 0.00055 19.9 2.1 0.38 10.6 0.0 5.0 7 0 0 7 7 7 1 Eukaryotic translation initiation factor eIF2A DUF1513 PF07433.11 EDO06060.1 - 0.007 15.5 0.9 4.8 6.2 0.0 4.1 4 0 0 4 4 4 1 Protein of unknown function (DUF1513) Nup160 PF11715.8 EDO06060.1 - 0.011 14.4 5.0 4.1 5.9 0.3 4.0 2 1 2 4 4 4 0 Nucleoporin Nup120/160 Kelch_6 PF13964.6 EDO06060.1 - 0.023 15.0 2.1 4.6 7.7 0.1 4.1 3 0 0 3 3 3 0 Kelch motif OHA PF14418.6 EDO06061.1 - 1.3e-21 76.2 0.0 2.8e-21 75.1 0.0 1.6 1 0 0 1 1 1 1 OST-HTH Associated domain ANAPC3 PF12895.7 EDO06062.1 - 9.7e-06 25.7 4.9 0.00013 22.1 0.6 3.6 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 Arm PF00514.23 EDO06062.1 - 0.00042 20.3 0.3 3.9 7.7 0.1 4.7 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat TPR_8 PF13181.6 EDO06062.1 - 0.03 14.5 3.0 0.064 13.5 0.4 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat RPAP1_N PF08621.10 EDO06062.1 - 0.05 13.4 1.5 0.24 11.2 1.5 2.2 1 0 0 1 1 1 0 RPAP1-like, N-terminal TPR_19 PF14559.6 EDO06062.1 - 0.095 13.2 4.3 0.11 13.1 0.0 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 EDO06062.1 - 1.8 8.9 5.2 2.9 8.2 0.7 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EDO06062.1 - 8.4 6.8 9.7 14 6.1 0.4 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat ABA_GPCR PF12430.8 EDO06063.1 - 2e-26 92.9 9.9 5.6e-26 91.4 9.9 1.7 1 0 0 1 1 1 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 EDO06063.1 - 0.0016 18.4 0.2 0.0082 16.2 0.0 2.1 2 0 0 2 2 2 1 The Golgi pH Regulator (GPHR) Family N-terminal Ribosomal_S6 PF01250.17 EDO06064.1 - 2.6e-12 46.9 0.0 3.1e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 Ribosomal_L44 PF00935.19 EDO06065.1 - 9.8e-34 115.7 15.2 1.4e-33 115.2 15.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L44 SesA PF17107.5 EDO06066.1 - 0.0044 17.2 0.5 0.018 15.2 0.1 2.2 2 0 0 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases RPA PF10134.9 EDO06066.1 - 0.019 14.5 0.3 0.033 13.7 0.3 1.4 1 0 0 1 1 1 0 Replication initiator protein A Alpha-2-MRAP_C PF06401.11 EDO06066.1 - 0.048 13.6 1.2 0.12 12.3 1.2 1.6 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, C-terminal domain Condensin2nSMC PF12422.8 EDO06066.1 - 0.1 12.8 0.1 0.25 11.5 0.1 1.6 1 0 0 1 1 1 0 Condensin II non structural maintenance of chromosomes subunit DUF4890 PF16231.5 EDO06066.1 - 0.15 12.6 0.3 0.3 11.6 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4890) TBCC_N PF16752.5 EDO06066.1 - 0.15 12.5 2.3 0.74 10.3 2.3 2.2 1 1 0 1 1 1 0 Tubulin-specific chaperone C N-terminal domain DUF5617 PF18493.1 EDO06066.1 - 0.16 12.0 1.1 2.5 8.3 0.2 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5617) Peptidase_C14 PF00656.22 EDO06067.1 - 1.1e-26 94.3 0.0 2.4e-26 93.2 0.0 1.6 1 0 0 1 1 1 1 Caspase domain RHD3 PF05879.12 EDO06068.1 - 3.1e-96 323.2 0.0 4.1e-96 322.8 0.0 1.1 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) Dynamin_N PF00350.23 EDO06068.1 - 0.0029 17.7 0.2 0.0078 16.3 0.2 1.7 1 0 0 1 1 1 1 Dynamin family GBP PF02263.19 EDO06068.1 - 0.0037 16.6 0.0 0.0066 15.7 0.0 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.23 EDO06068.1 - 0.011 15.8 0.0 0.029 14.5 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase RrnaAD PF00398.20 EDO06069.1 - 3.6e-55 186.9 0.0 4.7e-55 186.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EDO06069.1 - 6.5e-09 36.4 0.0 1.2e-08 35.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDO06069.1 - 5.2e-08 32.8 0.0 8.1e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDO06069.1 - 2.7e-05 24.7 0.0 5.2e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDO06069.1 - 4.4e-05 22.9 0.0 7.3e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EDO06069.1 - 0.00011 21.7 0.0 0.0002 20.9 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_12 PF08242.12 EDO06069.1 - 0.0013 19.4 0.0 0.0022 18.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDO06069.1 - 0.0022 17.8 0.0 0.0032 17.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EDO06069.1 - 0.0033 17.2 0.0 0.0054 16.5 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) NodS PF05401.11 EDO06069.1 - 0.021 14.4 0.0 0.032 13.8 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) DREV PF05219.12 EDO06069.1 - 0.039 13.0 0.0 0.057 12.5 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase PrmA PF06325.13 EDO06069.1 - 0.05 13.0 0.0 0.08 12.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF43 PF01861.16 EDO06069.1 - 0.088 12.0 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain HEAT PF02985.22 EDO06070.1 - 5.7e-16 57.2 20.5 0.052 13.8 0.0 9.9 11 0 0 11 11 11 5 HEAT repeat HEAT_2 PF13646.6 EDO06070.1 - 9.5e-10 38.7 0.2 1 9.8 0.0 5.9 5 2 1 6 6 6 3 HEAT repeats CLASP_N PF12348.8 EDO06070.1 - 3.5e-05 23.5 0.4 0.15 11.6 0.1 3.6 2 2 0 2 2 2 2 CLASP N terminal Vac14_Fab1_bd PF12755.7 EDO06070.1 - 0.00031 21.3 4.0 0.22 12.2 0.0 4.9 4 1 0 5 5 5 1 Vacuolar 14 Fab1-binding region Tti2 PF10521.9 EDO06070.1 - 0.00044 19.9 0.1 0.54 9.8 0.0 3.5 4 0 0 4 4 4 2 Tti2 family Adaptin_N PF01602.20 EDO06070.1 - 0.0029 16.2 7.8 1.8 7.0 0.1 3.4 3 0 0 3 3 3 3 Adaptin N terminal region DRIM PF07539.12 EDO06070.1 - 0.0089 14.4 0.4 2.4 6.3 0.1 2.3 2 0 0 2 2 2 2 Down-regulated in metastasis MMS19_N PF14500.6 EDO06070.1 - 0.019 14.5 0.3 0.49 9.9 0.0 2.7 2 1 1 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II RYDR_ITPR PF01365.21 EDO06070.1 - 0.089 12.2 0.7 0.2 11.1 0.7 1.6 1 0 0 1 1 1 0 RIH domain HEAT_EZ PF13513.6 EDO06070.1 - 0.55 10.8 4.2 78 3.9 0.0 5.3 8 0 0 8 8 8 0 HEAT-like repeat ALAD PF00490.21 EDO06071.1 - 1.7e-82 277.2 0.0 2e-82 276.9 0.0 1.1 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase Peptidase_M16_C PF05193.21 EDO06072.1 - 8.8e-19 68.2 0.7 3.9e-09 36.8 0.0 3.9 3 1 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EDO06072.1 - 3.3e-17 62.9 0.2 3e-15 56.5 0.1 2.7 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) T3SS_needle_E PF08988.10 EDO06072.1 - 0.0041 17.2 0.6 6.2 7.1 0.1 3.6 3 0 0 3 3 3 2 Type III secretion system, cytoplasmic E component of needle zf-B_box PF00643.24 EDO06073.1 - 7e-11 42.1 15.7 3.7e-06 27.0 5.4 2.6 2 0 0 2 2 2 2 B-box zinc finger Prot_inhib_II PF02428.15 EDO06073.1 - 0.068 13.6 0.6 0.068 13.6 0.6 2.3 2 0 0 2 2 2 0 Potato type II proteinase inhibitor family RNA_pol_L_2 PF13656.6 EDO06074.1 - 6.4e-26 89.9 0.0 7.3e-26 89.7 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EDO06074.1 - 1.5e-06 27.6 0.0 2.2e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain tRNA-synt_2 PF00152.20 EDO06075.1 - 1.2e-61 208.6 0.0 2.2e-61 207.6 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDO06075.1 - 6.1e-07 29.3 0.1 1.1e-06 28.6 0.1 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EDO06075.1 - 8.3e-07 28.7 0.0 0.00013 21.6 0.0 2.6 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) Prefoldin_2 PF01920.20 EDO06076.1 - 1e-15 57.6 2.7 1.3e-15 57.3 2.7 1.1 1 0 0 1 1 1 1 Prefoldin subunit ApoLp-III PF07464.11 EDO06076.1 - 0.021 14.9 0.2 0.04 14.0 0.2 1.4 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) APG6_N PF17675.1 EDO06076.1 - 1.2 9.7 8.3 2.1 8.9 3.3 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region s48_45 PF07422.13 EDO06077.1 - 7.1e-24 84.5 8.2 3.1e-10 40.6 0.0 5.1 5 0 0 5 5 5 4 Sexual stage antigen s48/45 domain s48_45 PF07422.13 EDO06078.1 - 3.3e-20 72.7 4.5 1e-09 38.9 0.2 4.7 4 0 0 4 4 4 4 Sexual stage antigen s48/45 domain s48_45 PF07422.13 EDO06079.1 - 1.2e-21 77.3 7.2 9.9e-10 39.0 0.2 4.5 5 0 0 5 5 5 3 Sexual stage antigen s48/45 domain Torus PF16131.5 EDO06080.1 - 1e-32 113.0 0.4 1e-32 113.0 0.4 2.4 3 0 0 3 3 3 1 Torus domain RRM_1 PF00076.22 EDO06080.1 - 1e-06 28.5 0.0 2e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_4 PF18044.1 EDO06080.1 - 0.015 15.1 8.6 0.027 14.3 8.6 1.4 1 0 0 1 1 1 0 CCCH-type zinc finger Nup35_RRM_2 PF14605.6 EDO06080.1 - 0.061 13.3 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif zf_CCCH_4 PF18345.1 EDO06080.1 - 0.07 13.2 5.3 0.14 12.3 5.3 1.5 1 0 0 1 1 1 0 Zinc finger domain zf-CCCH PF00642.24 EDO06080.1 - 0.46 10.5 7.4 0.86 9.6 7.4 1.5 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF2284 PF10050.9 EDO06080.1 - 0.72 9.6 4.3 13 5.5 0.7 2.3 2 0 0 2 2 2 0 Predicted metal-binding protein (DUF2284) TIM PF00121.18 EDO06081.1 - 7.4e-80 267.8 0.0 8.4e-80 267.6 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase CLP1_P PF16575.5 EDO06082.1 - 2e-26 93.0 0.0 3.4e-26 92.2 0.0 1.4 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop DUF4288 PF14119.6 EDO06082.1 - 0.13 12.7 0.0 0.32 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4288) Rad21_Rec8 PF04824.16 EDO06083.1 - 8.8e-08 31.3 0.0 2.3e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein CNDH2_C PF16858.5 EDO06083.1 - 0.0045 16.9 0.0 0.0045 16.9 0.0 2.3 3 0 0 3 3 3 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term Motile_Sperm PF00635.26 EDO06084.1 - 1.1e-23 83.2 0.0 1.8e-23 82.5 0.0 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain ASH PF15780.5 EDO06084.1 - 0.027 14.7 0.0 0.051 13.8 0.0 1.4 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF2203 PF09969.9 EDO06084.1 - 0.06 14.1 0.0 0.093 13.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) RNA_pol_Rpb6 PF01192.22 EDO06085.1 - 1.3e-17 63.4 0.0 2.1e-17 62.7 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 LNS2 PF08235.13 EDO06086.1 - 1.9e-92 308.8 0.0 2.6e-92 308.4 0.0 1.1 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 EDO06086.1 - 2.5e-24 85.2 0.0 1.4e-18 66.7 0.0 2.4 2 0 0 2 2 2 2 lipin, N-terminal conserved region Lipin_mid PF16876.5 EDO06086.1 - 8.9e-19 67.5 0.0 1.6e-18 66.7 0.0 1.4 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain DHHC PF01529.20 EDO06087.1 - 4.4e-27 94.8 13.8 4.4e-27 94.8 13.8 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ank_4 PF13637.6 EDO06087.1 - 2.8e-21 75.6 2.3 2.6e-09 37.5 0.1 3.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDO06087.1 - 1.6e-20 73.5 0.0 5.7e-09 36.4 0.1 3.2 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDO06087.1 - 2.7e-14 51.9 7.8 0.0076 16.7 0.1 5.4 6 0 0 6 6 6 4 Ankyrin repeat Ank PF00023.30 EDO06087.1 - 3e-14 52.7 6.0 2.2e-05 24.7 0.0 5.4 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 EDO06087.1 - 5e-13 49.0 1.9 0.0084 16.4 0.1 5.4 3 2 2 5 5 5 4 Ankyrin repeats (many copies) GCP_N_terminal PF17681.1 EDO06088.1 - 1.1e-32 114.0 1.7 1.1e-32 114.0 1.7 1.9 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EDO06088.1 - 1.6e-28 100.1 15.4 1.6e-28 100.1 15.4 1.5 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal DUF1944 PF09175.10 EDO06088.1 - 0.028 14.3 0.9 0.071 13.0 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1944) Oxygenase-NA PF09859.9 EDO06088.1 - 0.075 12.6 0.5 0.17 11.4 0.5 1.6 1 0 0 1 1 1 0 Oxygenase, catalysing oxidative methylation of damaged DNA 2-oxoacid_dh PF00198.23 EDO06089.1 - 6e-64 215.7 0.0 9.4e-64 215.0 0.0 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EDO06089.1 - 2.9e-17 62.2 0.3 8.4e-17 60.8 0.3 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EDO06089.1 - 5.2e-12 45.9 0.3 2.3e-10 40.6 0.1 3.2 2 1 0 2 2 2 1 e3 binding domain HlyD_D23 PF16576.5 EDO06089.1 - 0.00026 20.3 0.2 0.00058 19.1 0.0 1.6 2 0 0 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 EDO06089.1 - 0.00058 19.6 0.0 0.0017 18.2 0.0 1.7 1 0 0 1 1 1 1 Biotin-lipoyl like GCV_H PF01597.19 EDO06089.1 - 0.11 12.3 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Glycine cleavage H-protein IMCp PF12314.8 EDO06090.1 - 3.1e-23 81.9 102.7 8.8e-17 61.2 45.9 4.3 1 1 3 4 4 4 3 Inner membrane complex protein TLD PF07534.16 EDO06091.1 - 1e-18 67.9 0.2 1.9e-18 67.0 0.2 1.4 1 0 0 1 1 1 1 TLD RabGAP-TBC PF00566.18 EDO06091.1 - 3.4e-08 33.4 2.2 3.4e-08 33.4 2.2 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Rad51 PF08423.11 EDO06092.1 - 7.3e-22 77.8 0.0 1e-21 77.4 0.0 1.2 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 EDO06092.1 - 2.8e-06 27.1 0.2 5.2e-05 22.9 0.2 2.1 1 1 0 1 1 1 1 AAA domain RecA PF00154.21 EDO06092.1 - 6.5e-06 25.8 0.2 0.00037 20.1 0.0 2.1 2 0 0 2 2 2 1 recA bacterial DNA recombination protein AAA_22 PF13401.6 EDO06092.1 - 5.1e-05 23.6 0.0 9.7e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain CobU PF02283.16 EDO06092.1 - 0.0001 21.9 0.1 0.0063 16.1 0.0 2.1 1 1 1 2 2 2 1 Cobinamide kinase / cobinamide phosphate guanyltransferase ATPase PF06745.13 EDO06092.1 - 0.0002 20.8 0.0 0.0061 15.9 0.0 2.2 2 0 0 2 2 2 1 KaiC SEFIR PF08357.11 EDO06092.1 - 0.0046 17.2 0.0 0.0087 16.3 0.0 1.4 1 0 0 1 1 1 1 SEFIR domain AAA_16 PF13191.6 EDO06092.1 - 0.0083 16.5 0.0 0.015 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 EDO06092.1 - 0.0083 15.9 0.0 0.022 14.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDO06092.1 - 0.012 15.9 0.1 0.34 11.2 0.0 2.4 2 1 1 3 3 3 0 AAA domain AAA PF00004.29 EDO06092.1 - 0.05 14.0 0.1 0.86 10.0 0.1 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 EDO06092.1 - 0.065 13.0 0.0 0.13 12.1 0.0 1.7 1 1 0 1 1 1 0 DEAD/DEAH box helicase PhoH PF02562.16 EDO06092.1 - 0.084 12.3 0.0 3.2 7.1 0.0 2.1 2 0 0 2 2 2 0 PhoH-like protein ATPase_2 PF01637.18 EDO06092.1 - 0.11 12.4 0.0 0.25 11.2 0.0 1.6 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea NACHT PF05729.12 EDO06092.1 - 0.13 12.2 0.0 0.21 11.5 0.0 1.5 1 1 0 1 1 1 0 NACHT domain DUF2075 PF09848.9 EDO06092.1 - 0.14 11.4 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Fumble PF03630.14 EDO06093.1 - 5.3e-48 163.9 3.1 7.8e-48 163.3 3.1 1.2 1 0 0 1 1 1 1 Fumble VESA1_N PF12785.7 EDO06095.1 - 1.2e-21 77.3 32.6 2.7e-09 36.5 0.0 4.4 2 1 1 4 4 4 4 Variant erythrocyte surface antigen-1 F-box-like_2 PF13013.6 EDO06096.1 - 1.7e-14 53.6 4.0 0.00011 22.1 0.1 3.2 2 1 1 3 3 3 3 F-box-like domain O_Spanin_T7 PF17531.2 EDO06096.1 - 0.093 12.8 1.2 0.97 9.5 0.0 2.4 2 0 0 2 2 2 0 outer-membrane spanin sub-unit F-box-like_2 PF13013.6 EDO06097.1 - 6.4e-09 35.7 1.8 8.6e-08 32.1 0.5 1.7 1 1 1 2 2 2 2 F-box-like domain VESA1_N PF12785.7 EDO06098.1 - 5.5e-207 688.2 27.0 5.5e-207 688.2 27.0 2.3 2 0 0 2 2 2 1 Variant erythrocyte surface antigen-1 MnmE_helical PF12631.7 EDO06098.1 - 0.0011 19.2 0.1 0.47 10.6 0.0 2.5 2 0 0 2 2 2 2 MnmE helical domain Spc7 PF08317.11 EDO06098.1 - 0.067 12.1 6.1 0.17 10.7 6.1 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein EzrA PF06160.12 EDO06098.1 - 0.1 10.7 1.3 0.2 9.8 1.3 1.3 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Baculo_PEP_C PF04513.12 EDO06098.1 - 0.12 12.4 1.6 0.46 10.5 0.1 2.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2884 PF11101.8 EDO06098.1 - 0.22 11.0 1.2 0.28 10.7 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2884) Ferritin PF00210.24 EDO06098.1 - 0.32 10.9 2.6 3.2 7.7 0.9 2.5 2 0 0 2 2 2 0 Ferritin-like domain SMBP PF16785.5 EDO06098.1 - 0.5 10.6 2.2 2.9 8.1 0.9 2.4 2 0 0 2 2 2 0 Small metal-binding protein TPR_MLP1_2 PF07926.12 EDO06098.1 - 0.52 10.4 4.3 1.1 9.3 4.3 1.6 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein IFT57 PF10498.9 EDO06098.1 - 0.57 9.1 3.3 1.2 8.0 3.3 1.4 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 YscO-like PF16789.5 EDO06098.1 - 0.83 9.7 6.6 3.3 7.7 2.9 2.5 2 0 0 2 2 2 0 YscO-like protein PEP-utilisers_N PF05524.13 EDO06098.1 - 0.96 9.6 2.6 36 4.6 0.0 2.4 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal DHR10 PF18595.1 EDO06098.1 - 1.5 8.9 7.4 3.5 7.7 7.4 1.7 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain YtxH PF12732.7 EDO06098.1 - 6.2 7.4 7.5 55 4.4 7.5 2.4 1 1 0 1 1 1 0 YtxH-like protein VESA1_N PF12785.7 EDO06099.1 - 1.6e-210 699.9 20.7 1.6e-210 699.9 20.7 2.8 3 0 0 3 3 2 1 Variant erythrocyte surface antigen-1 Borrelia_REV PF03978.13 EDO06099.1 - 7.2e-05 22.8 0.6 0.066 13.2 0.7 2.4 2 0 0 2 2 2 2 Borrelia burgdorferi REV protein Jnk-SapK_ap_N PF09744.9 EDO06099.1 - 0.0026 18.0 3.4 0.0072 16.6 3.4 1.7 1 0 0 1 1 1 1 JNK_SAPK-associated protein-1 MnmE_helical PF12631.7 EDO06099.1 - 0.05 13.8 1.0 0.18 12.0 0.1 2.1 2 0 0 2 2 2 0 MnmE helical domain Apolipoprotein PF01442.18 EDO06099.1 - 0.053 13.4 5.7 0.48 10.3 4.0 2.4 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain HsbA PF12296.8 EDO06099.1 - 0.059 13.8 2.1 7.8 6.9 0.0 3.6 3 1 0 4 4 3 0 Hydrophobic surface binding protein A DUF2524 PF10732.9 EDO06099.1 - 0.087 13.1 0.4 14 6.1 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) Baculo_PEP_C PF04513.12 EDO06099.1 - 0.096 12.7 0.5 5.1 7.1 0.3 2.7 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus COG2 PF06148.11 EDO06099.1 - 0.25 11.4 2.2 10 6.2 0.0 2.5 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Nup88 PF10168.9 EDO06099.1 - 0.5 8.1 1.6 1.2 6.9 0.0 1.9 2 0 0 2 2 2 0 Nuclear pore component DUF5082 PF16888.5 EDO06099.1 - 0.54 10.5 3.4 3.9 7.8 2.3 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) Laminin_II PF06009.12 EDO06099.1 - 0.76 9.8 3.7 20 5.2 0.6 2.3 2 0 0 2 2 2 0 Laminin Domain II DUF1664 PF07889.12 EDO06099.1 - 1.1 9.3 2.9 17 5.4 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FliJ PF02050.16 EDO06099.1 - 1.3 9.2 10.2 15 5.8 2.6 3.3 3 0 0 3 3 3 0 Flagellar FliJ protein ApoLp-III PF07464.11 EDO06099.1 - 2 8.5 7.8 0.4 10.8 0.7 2.8 2 1 1 3 3 2 0 Apolipophorin-III precursor (apoLp-III) Spc7 PF08317.11 EDO06099.1 - 2.1 7.2 9.7 1.6 7.5 4.1 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 EDO06099.1 - 2.7 8.1 8.7 3.3 7.8 4.6 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein zf-CCCH PF00642.24 EDO06101.1 - 1.5e-08 34.3 19.8 1.7e-06 27.7 6.2 4.1 3 1 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDO06101.1 - 1.7e-05 24.7 6.6 1.7e-05 24.7 6.6 5.0 5 0 0 5 5 5 1 Zinc finger domain zf-CCCH_4 PF18044.1 EDO06101.1 - 0.00037 20.2 4.5 0.00037 20.2 4.5 4.2 3 2 0 3 3 3 2 CCCH-type zinc finger Torus PF16131.5 EDO06101.1 - 7.9 7.2 14.4 0.14 12.8 2.7 2.9 1 1 2 3 3 3 0 Torus domain zf-C2H2_jaz PF12171.8 EDO06102.1 - 1.9e-08 34.4 1.4 3.4e-08 33.5 1.4 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EDO06102.1 - 0.0029 18.0 2.0 0.0073 16.7 2.0 1.8 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-U1 PF06220.12 EDO06102.1 - 0.023 14.4 2.3 0.052 13.3 2.3 1.6 1 0 0 1 1 1 0 U1 zinc finger zf-C2H2_2 PF12756.7 EDO06102.1 - 0.024 15.0 2.1 0.038 14.3 2.0 1.6 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Pullulanase_Ins PF18494.1 EDO06102.1 - 0.029 14.8 0.8 2.1 8.9 0.0 2.1 1 1 1 2 2 2 0 Pullulanase Ins domain zf-C2H2_4 PF13894.6 EDO06102.1 - 0.078 13.9 0.4 0.078 13.9 0.4 1.9 2 0 0 2 2 2 0 C2H2-type zinc finger Wbp11 PF09429.10 EDO06102.1 - 0.59 10.6 7.4 0.082 13.3 2.3 1.9 2 0 0 2 2 2 0 WW domain binding protein 11 JAB PF01398.21 EDO06103.1 - 1e-16 60.9 0.1 2e-16 60.0 0.1 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EDO06103.1 - 0.00018 21.9 0.2 0.00031 21.2 0.2 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function MA3 PF02847.17 EDO06103.1 - 0.056 13.4 0.0 0.16 11.9 0.0 1.8 1 0 0 1 1 1 0 MA3 domain Sas10_Utp3 PF04000.15 EDO06103.1 - 0.083 13.5 0.5 0.21 12.2 0.5 1.7 1 0 0 1 1 1 0 Sas10/Utp3/C1D family SAPS PF04499.15 EDO06105.1 - 0.031 13.1 0.1 0.054 12.3 0.1 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein ATP-synt_ab PF00006.25 EDO06106.1 - 2e-64 217.2 0.0 2.8e-64 216.7 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EDO06106.1 - 1.8e-11 44.4 1.8 3.2e-11 43.6 1.8 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.10 EDO06106.1 - 0.028 14.6 0.2 0.077 13.2 0.2 1.7 1 0 0 1 1 1 0 HAS barrel domain BIRC6 PF12356.8 EDO06107.1 - 0.046 13.2 0.2 0.072 12.5 0.2 1.2 1 0 0 1 1 1 0 Baculoviral IAP repeat-containing protein 6 Methyltransf_9 PF08003.11 EDO06108.1 - 4.2 6.2 10.4 0.13 11.1 1.2 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1698) PCI PF01399.27 EDO06109.1 - 1.7e-20 73.5 0.5 2.5e-19 69.7 0.1 2.5 2 0 0 2 2 2 1 PCI domain Rpn3_C PF08375.11 EDO06109.1 - 3.3e-15 56.2 0.4 1.1e-14 54.6 0.4 1.9 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal SAM_Ste50p PF09235.10 EDO06109.1 - 0.011 15.9 0.0 0.31 11.3 0.0 2.8 2 0 0 2 2 2 0 Ste50p, sterile alpha motif TPR_2 PF07719.17 EDO06109.1 - 0.045 13.9 0.8 0.045 13.9 0.8 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Phage_term_smal PF05944.12 EDO06109.1 - 0.11 12.5 0.1 0.32 11.0 0.0 1.8 2 0 0 2 2 2 0 Phage small terminase subunit SHE3 PF17078.5 EDO06110.1 - 0.00021 21.1 7.3 0.00021 21.1 7.3 1.9 2 0 0 2 2 2 1 SWI5-dependent HO expression protein 3 YabA PF06156.13 EDO06110.1 - 0.0034 18.0 7.1 13 6.5 0.1 4.0 3 1 0 3 3 3 0 Initiation control protein YabA Csm1_N PF18504.1 EDO06110.1 - 0.015 15.7 6.9 2.1 8.8 0.4 3.8 3 1 0 3 3 3 0 Csm1 N-terminal domain Fez1 PF06818.15 EDO06110.1 - 0.027 14.9 6.7 0.036 14.5 3.1 2.2 2 0 0 2 2 2 0 Fez1 HALZ PF02183.18 EDO06110.1 - 0.029 14.6 15.5 2.7 8.3 0.6 4.6 4 0 0 4 4 4 0 Homeobox associated leucine zipper DUF4201 PF13870.6 EDO06110.1 - 0.042 13.6 0.3 0.042 13.6 0.3 2.8 2 1 0 3 3 3 0 Domain of unknown function (DUF4201) bZIP_1 PF00170.21 EDO06110.1 - 0.062 13.4 7.6 4.8 7.3 0.0 4.2 4 0 0 4 4 4 0 bZIP transcription factor Bcr-Abl_Oligo PF09036.10 EDO06110.1 - 0.083 12.9 0.1 0.3 11.1 0.1 2.0 1 0 0 1 1 1 0 Bcr-Abl oncoprotein oligomerisation domain FAM184 PF15665.5 EDO06110.1 - 0.086 12.6 7.4 0.02 14.7 3.5 1.9 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B Phage_GP20 PF06810.11 EDO06110.1 - 0.15 11.8 0.4 9.6 6.0 0.0 3.1 3 0 0 3 3 3 0 Phage minor structural protein GP20 ZapB PF06005.12 EDO06110.1 - 0.21 12.1 13.0 4.2 7.9 0.1 4.3 3 1 1 4 4 4 0 Cell division protein ZapB GrpE PF01025.19 EDO06110.1 - 0.25 11.0 3.6 0.98 9.1 0.0 2.8 3 0 0 3 3 3 0 GrpE DivIC PF04977.15 EDO06110.1 - 0.26 11.1 9.3 3.1 7.6 0.0 4.1 3 1 2 5 5 5 0 Septum formation initiator PRKG1_interact PF15898.5 EDO06110.1 - 0.27 12.1 8.0 2.4 9.1 2.5 3.3 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain APC_N_CC PF16689.5 EDO06110.1 - 0.29 11.2 8.1 8.3 6.6 0.1 4.2 4 0 0 4 4 4 0 Coiled-coil N-terminus of APC, dimerisation domain DUF2381 PF09544.10 EDO06110.1 - 0.36 10.3 2.5 1.1 8.7 0.0 2.6 2 1 0 3 3 3 0 Protein of unknown function (DUF2381) VPS11_C PF12451.8 EDO06110.1 - 0.44 10.8 5.1 5.2 7.4 0.2 3.7 3 0 0 3 3 3 0 Vacuolar protein sorting protein 11 C terminal FlaC_arch PF05377.11 EDO06110.1 - 0.83 10.1 6.6 47 4.5 0.0 3.8 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) vATP-synt_AC39 PF01992.16 EDO06111.1 - 2.1e-81 274.0 0.2 2.4e-81 273.8 0.2 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit HEPN PF05168.14 EDO06111.1 - 0.19 11.9 0.5 14 5.8 0.1 2.7 2 1 1 3 3 3 0 HEPN domain PRT_C PF08372.10 EDO06112.1 - 0.0028 17.4 3.4 0.0082 15.9 0.0 2.7 2 0 0 2 2 2 1 Plant phosphoribosyltransferase C-terminal PH PF00169.29 EDO06112.1 - 0.014 15.9 0.1 0.1 13.1 0.1 2.6 1 0 0 1 1 1 0 PH domain YL1 PF05764.13 EDO06113.1 - 8e-31 108.0 24.4 8e-31 108.0 24.4 2.1 2 0 0 2 2 2 1 YL1 nuclear protein YL1_C PF08265.11 EDO06113.1 - 2.4e-11 43.2 2.4 6e-11 41.9 0.8 2.2 2 0 0 2 2 2 1 YL1 nuclear protein C-terminal domain Pga1 PF10333.9 EDO06113.1 - 1.4 8.7 3.3 0.84 9.5 1.1 1.7 2 0 0 2 2 2 0 GPI-Mannosyltransferase II co-activator DivIC PF04977.15 EDO06115.1 - 2.2e-06 27.3 11.8 0.0058 16.4 1.5 3.8 3 1 0 3 3 3 2 Septum formation initiator CENP-F_leu_zip PF10473.9 EDO06115.1 - 0.00095 19.2 6.1 0.00095 19.2 6.1 3.5 4 0 0 4 4 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Rootletin PF15035.6 EDO06115.1 - 0.002 18.2 5.6 0.002 18.2 5.6 3.0 3 1 0 3 3 3 1 Ciliary rootlet component, centrosome cohesion YabA PF06156.13 EDO06115.1 - 0.0078 16.8 17.0 0.21 12.2 4.3 3.9 3 1 0 3 3 3 2 Initiation control protein YabA SlyX PF04102.12 EDO06115.1 - 0.019 15.6 15.6 0.22 12.2 1.7 5.1 4 1 1 5 5 5 0 SlyX TolA_bind_tri PF16331.5 EDO06115.1 - 0.024 14.7 16.7 0.33 11.1 5.8 4.3 3 1 1 4 4 4 0 TolA binding protein trimerisation DUF2383 PF09537.10 EDO06115.1 - 0.045 14.1 0.2 0.045 14.1 0.2 2.7 3 1 0 3 3 3 0 Domain of unknown function (DUF2383) ZapB PF06005.12 EDO06115.1 - 0.085 13.3 23.8 0.31 11.5 6.6 4.7 4 1 1 5 5 5 0 Cell division protein ZapB bZIP_1 PF00170.21 EDO06115.1 - 0.098 12.8 16.2 0.23 11.6 0.2 4.1 3 1 2 5 5 5 0 bZIP transcription factor Occludin_ELL PF07303.13 EDO06115.1 - 0.1 13.4 6.8 2 9.2 0.7 3.4 4 0 0 4 4 3 0 Occludin homology domain KASH_CCD PF14662.6 EDO06115.1 - 0.13 12.1 22.0 0.45 10.3 6.1 2.9 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH NPV_P10 PF05531.12 EDO06115.1 - 0.26 11.8 14.6 1.7 9.1 0.8 4.5 4 1 0 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF4200 PF13863.6 EDO06115.1 - 0.51 10.8 10.7 0.84 10.0 0.5 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) DUF2205 PF10224.9 EDO06115.1 - 0.6 10.1 11.5 5.9 7.0 0.1 3.3 3 0 0 3 3 3 0 Short coiled-coil protein DUF4201 PF13870.6 EDO06115.1 - 0.67 9.7 14.3 2.9 7.6 2.6 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4201) CENP-H PF05837.12 EDO06115.1 - 0.78 10.2 25.7 0.083 13.3 6.0 4.1 4 0 0 4 4 4 0 Centromere protein H (CENP-H) Csm1_N PF18504.1 EDO06115.1 - 0.86 10.0 17.7 5.3 7.5 0.2 4.7 3 1 1 4 4 4 0 Csm1 N-terminal domain TSC22 PF01166.18 EDO06115.1 - 1.1 9.6 17.5 0.88 9.9 1.1 4.2 3 1 1 4 4 3 0 TSC-22/dip/bun family TMF_TATA_bd PF12325.8 EDO06115.1 - 1.5 9.0 17.8 1.7 8.9 5.4 3.7 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding ADIP PF11559.8 EDO06115.1 - 1.6 8.8 23.4 0.22 11.6 6.0 3.8 4 0 0 4 4 4 0 Afadin- and alpha -actinin-Binding Shugoshin_N PF07558.11 EDO06115.1 - 2 8.3 7.3 1.1 9.2 1.8 3.0 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region DUF3135 PF11333.8 EDO06115.1 - 2.2 8.6 6.3 56 4.1 0.2 4.3 5 0 0 5 5 4 0 Protein of unknown function (DUF3135) Cep57_CLD_2 PF14197.6 EDO06115.1 - 2.5 8.2 20.7 0.44 10.7 0.8 4.4 3 1 1 4 4 4 0 Centrosome localisation domain of PPC89 KLRAQ PF10205.9 EDO06115.1 - 3 8.1 14.2 8.4 6.7 5.0 3.3 2 1 1 3 3 3 0 Predicted coiled-coil domain-containing protein DASH_Dam1 PF08653.10 EDO06115.1 - 3.1 7.7 5.7 20 5.1 0.7 3.2 3 0 0 3 3 2 0 DASH complex subunit Dam1 Sec34 PF04136.15 EDO06115.1 - 3.1 7.7 12.3 5.3 6.9 4.2 3.2 3 0 0 3 3 3 0 Sec34-like family DUF4482 PF14818.6 EDO06115.1 - 3.7 8.4 8.1 4.5 8.1 0.4 3.1 3 0 0 3 3 2 0 Domain of unknown function (DUF4482) Baculo_PEP_C PF04513.12 EDO06115.1 - 4.9 7.2 18.8 0.14 12.2 3.8 3.2 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Nsp1_C PF05064.13 EDO06115.1 - 5 7.0 12.0 0.032 14.0 2.2 2.3 3 0 0 3 3 2 0 Nsp1-like C-terminal region Fzo_mitofusin PF04799.13 EDO06115.1 - 5.1 6.6 8.7 6.7 6.2 1.2 3.0 3 0 0 3 3 3 0 fzo-like conserved region Mod_r PF07200.13 EDO06115.1 - 5.5 7.1 21.1 3.1 7.9 8.9 3.5 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein GIT_CC PF16559.5 EDO06115.1 - 5.5 6.9 17.9 0.51 10.2 0.2 3.8 4 1 0 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor PRKG1_interact PF15898.5 EDO06115.1 - 5.5 7.9 21.4 39 5.2 9.2 4.1 2 1 1 3 3 2 0 cGMP-dependent protein kinase interacting domain DUF2408 PF10303.9 EDO06115.1 - 6.7 7.3 10.4 1 9.9 0.6 3.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) NOC3p PF07540.11 EDO06116.1 - 0.0009 19.7 0.0 0.0044 17.4 0.0 2.3 1 0 0 1 1 1 1 Nucleolar complex-associated protein APC_u15 PF16636.5 EDO06116.1 - 0.35 11.3 6.8 0.34 11.4 1.4 2.6 2 0 0 2 2 2 0 Unstructured region on APC between APC_crr regions 5 and 6 CBF PF03914.17 EDO06116.1 - 0.58 10.2 4.3 3.7 7.6 1.5 3.1 2 1 0 2 2 2 0 CBF/Mak21 family UPF0113_N PF17833.1 EDO06117.1 - 4.7e-30 104.0 0.0 8e-30 103.2 0.0 1.4 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 EDO06117.1 - 1.4e-20 73.3 0.0 2.9e-20 72.3 0.0 1.5 2 0 0 2 2 2 1 UPF0113 PUA domain AP2 PF00847.20 EDO06118.1 - 6.9e-14 51.8 0.3 1.2e-13 51.0 0.3 1.4 1 0 0 1 1 1 1 AP2 domain BING4CT PF08149.11 EDO06118.1 - 0.15 11.8 0.0 0.75 9.6 0.0 2.1 2 0 0 2 2 2 0 BING4CT (NUC141) domain PC_rep PF01851.22 EDO06119.1 - 9.6e-26 88.9 19.0 8.6e-05 22.8 0.3 9.8 9 0 0 9 9 9 5 Proteasome/cyclosome repeat RPN2_C PF18004.1 EDO06119.1 - 2.4e-23 82.8 0.0 1.6e-22 80.2 0.0 2.1 1 1 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain HEAT_2 PF13646.6 EDO06119.1 - 6.4e-18 64.9 6.2 2.3e-11 43.9 0.1 4.9 4 1 1 5 5 5 2 HEAT repeats HEAT PF02985.22 EDO06119.1 - 2.1e-05 24.4 1.6 3.6 8.1 0.0 5.5 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 EDO06119.1 - 0.00069 20.1 2.3 0.033 14.7 0.0 4.1 3 1 1 4 4 4 1 HEAT-like repeat RNase_H_2 PF13482.6 EDO06119.1 - 0.032 14.2 0.0 0.07 13.1 0.0 1.5 1 0 0 1 1 1 0 RNase_H superfamily HEAT_PBS PF03130.16 EDO06119.1 - 0.071 13.8 3.4 8.3 7.4 0.2 4.5 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat Kelch_5 PF13854.6 EDO06120.1 - 3.7e-39 132.1 2.2 1.6e-05 24.7 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Metallophos PF00149.28 EDO06120.1 - 2.5e-30 106.5 0.3 4.8e-30 105.6 0.3 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Kelch_3 PF13415.6 EDO06120.1 - 1.1e-28 98.9 12.0 2e-06 27.9 0.2 7.9 8 0 0 8 8 8 4 Galactose oxidase, central domain Kelch_4 PF13418.6 EDO06120.1 - 8.6e-28 96.1 11.5 3.6e-08 33.3 0.5 6.5 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.15 EDO06120.1 - 2.1e-23 81.3 6.6 0.00019 21.2 0.0 6.6 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EDO06120.1 - 4.9e-23 80.6 5.4 0.0044 17.3 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.25 EDO06120.1 - 5.9e-23 80.2 0.9 1.1e-05 24.9 0.0 6.5 6 0 0 6 6 6 4 Kelch motif RAG2 PF03089.14 EDO06120.1 - 9.6e-05 21.5 0.1 0.45 9.5 0.0 3.7 4 0 0 4 4 4 2 Recombination activating protein 2 Baculo_RING PF05883.11 EDO06120.1 - 0.23 11.4 0.6 0.87 9.6 0.0 2.0 2 0 0 2 2 2 0 Baculovirus U-box/Ring-like domain Gal_Lectin PF02140.18 EDO06121.1 - 0.038 14.4 0.4 0.038 14.4 0.4 1.9 2 0 0 2 2 2 0 Galactose binding lectin domain Ribosomal_S3_C PF00189.20 EDO06122.1 - 4.6e-24 84.7 0.6 1.7e-23 82.9 1.1 1.7 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 EDO06122.1 - 5.1e-09 35.8 0.1 8.6e-09 35.1 0.1 1.4 1 0 0 1 1 1 1 KH domain Coilin_N PF15862.5 EDO06122.1 - 0.021 14.6 0.0 0.034 14.0 0.0 1.2 1 0 0 1 1 1 0 Coilin N-terminus UN_NPL4 PF11543.8 EDO06122.1 - 0.068 13.7 0.0 0.22 12.0 0.0 1.9 3 0 0 3 3 3 0 Nuclear pore localisation protein NPL4 BK_channel_a PF03493.18 EDO06124.1 - 3e-15 56.2 0.0 2.8e-14 53.1 0.0 2.3 2 0 0 2 2 2 1 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.16 EDO06124.1 - 1.2e-11 44.4 2.5 1.2e-11 44.4 2.5 1.9 2 0 0 2 2 2 1 Ion channel Ion_trans PF00520.31 EDO06124.1 - 0.00082 18.7 2.4 0.0017 17.6 2.4 1.4 1 0 0 1 1 1 1 Ion transport protein Med4 PF10018.9 EDO06125.1 - 0.0024 17.6 0.1 0.0035 17.0 0.1 1.2 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 COG6 PF06419.11 EDO06126.1 - 2.6e-05 22.7 0.9 2.6e-05 22.7 0.9 2.7 3 1 0 3 3 3 1 Conserved oligomeric complex COG6 Snapin_Pallidin PF14712.6 EDO06126.1 - 0.42 11.0 3.8 2.7 8.5 3.8 2.5 1 0 0 1 1 1 0 Snapin/Pallidin PMC2NT PF08066.12 EDO06126.1 - 0.45 11.2 4.7 0.73 10.6 0.2 3.3 3 0 0 3 3 3 0 PMC2NT (NUC016) domain COX6A PF02046.15 EDO06127.1 - 0.0014 19.0 0.2 0.0023 18.4 0.2 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa PFU PF09070.11 EDO06128.1 - 0.0072 16.6 0.1 0.015 15.6 0.1 1.4 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) PP2C PF00481.21 EDO06129.1 - 4.9e-35 121.4 0.0 6.1e-35 121.1 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EDO06129.1 - 0.00016 21.4 0.1 0.00063 19.4 0.1 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C SMC_N PF02463.19 EDO06130.1 - 5.9e-65 218.8 0.0 4.4e-64 215.9 0.0 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EDO06130.1 - 3.9e-16 59.4 0.1 1.6e-15 57.5 0.1 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.6 EDO06130.1 - 3.1e-10 40.3 0.0 1.7e-05 24.7 0.0 3.2 2 2 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 EDO06130.1 - 3.5e-10 40.2 1.4 0.00015 21.7 0.1 2.8 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EDO06130.1 - 9.2e-06 26.3 13.9 9.2e-06 26.3 13.9 5.5 2 2 0 2 2 1 1 AAA domain AAA_29 PF13555.6 EDO06130.1 - 0.031 14.0 0.0 0.073 12.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Fez1 PF06818.15 EDO06130.1 - 0.061 13.8 68.9 0.09 13.2 8.4 6.1 3 2 2 5 5 5 0 Fez1 LacI PF00356.21 EDO06130.1 - 0.096 12.5 0.5 0.52 10.1 0.0 2.6 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family ABC_tran PF00005.27 EDO06130.1 - 0.11 13.0 16.8 10 6.7 7.9 5.0 3 1 0 3 3 3 0 ABC transporter DUF5638 PF18688.1 EDO06130.1 - 0.96 9.8 5.5 0.9 9.9 0.2 3.4 4 0 0 4 4 4 0 Family of unknown function (DUF5638) Spc7 PF08317.11 EDO06130.1 - 1.2 7.9 71.3 0.43 9.4 11.3 6.1 4 2 1 5 5 5 0 Spc7 kinetochore protein Baculo_PEP_C PF04513.12 EDO06130.1 - 9.6 6.2 31.5 0.51 10.4 1.8 5.3 3 3 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Histone PF00125.24 EDO06132.1 - 3.8e-16 59.6 0.8 4.4e-16 59.4 0.8 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EDO06132.1 - 4e-06 27.0 0.2 8.6e-06 26.0 0.2 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EDO06132.1 - 0.0013 19.1 0.1 0.0021 18.5 0.1 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CactinC_cactus PF09732.9 EDO06133.1 - 0.019 14.9 0.2 0.035 14.1 0.2 1.4 1 0 0 1 1 1 0 Cactus-binding C-terminus of cactin protein Myb_DNA-binding PF00249.31 EDO06134.1 - 4.3e-16 58.8 0.4 1.6e-07 31.4 0.1 3.1 2 0 0 2 2 2 2 Myb-like DNA-binding domain DnaJ PF00226.31 EDO06134.1 - 6.1e-11 42.3 0.3 4e-09 36.5 0.3 2.8 1 1 0 1 1 1 1 DnaJ domain Myb_DNA-bind_6 PF13921.6 EDO06134.1 - 3.4e-09 36.8 0.2 0.00046 20.4 0.0 3.6 3 0 0 3 3 3 2 Myb-like DNA-binding domain RRM_1 PF00076.22 EDO06135.1 - 1.3e-58 194.7 4.0 4.5e-17 61.6 0.1 6.1 5 1 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDO06135.1 - 3.1e-09 36.5 0.0 1.5e-07 31.1 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDO06135.1 - 0.0017 18.2 0.1 0.62 10.0 0.0 3.9 5 0 0 5 5 5 1 Occluded RNA-recognition motif Smg4_UPF3 PF03467.15 EDO06135.1 - 0.0024 17.9 0.1 0.16 12.0 0.0 3.3 3 0 0 3 3 3 1 Smg-4/UPF3 family RRM_7 PF16367.5 EDO06135.1 - 0.012 15.7 0.0 0.9 9.7 0.0 2.8 3 0 0 3 3 3 0 RNA recognition motif NosL PF05573.12 EDO06135.1 - 0.16 12.3 0.1 0.38 11.1 0.1 1.6 1 0 0 1 1 1 0 NosL Peptidase_C97 PF05903.14 EDO06137.1 - 5.4e-31 107.5 0.1 7.7e-31 107.0 0.1 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain TMEM70 PF06979.12 EDO06137.1 - 0.091 13.2 1.0 0.17 12.3 0.5 1.7 2 0 0 2 2 2 0 Assembly, mitochondrial proton-transport ATP synth complex POTRA_1 PF08478.10 EDO06137.1 - 0.17 12.2 0.0 0.32 11.3 0.0 1.4 1 0 0 1 1 1 0 POTRA domain, FtsQ-type Symplekin_C PF12295.8 EDO06138.1 - 1.6e-33 116.4 0.5 4.6e-33 114.9 0.5 1.8 1 0 0 1 1 1 1 Symplekin tight junction protein C terminal PCI PF01399.27 EDO06140.1 - 1.1e-08 35.5 0.4 3.2e-08 34.0 0.1 2.1 2 0 0 2 2 2 1 PCI domain eIF3m_C_helix PF18005.1 EDO06140.1 - 5.2e-05 22.8 1.1 5.2e-05 22.8 1.1 1.8 2 0 0 2 2 2 1 eIF3 subunit M, C-terminal helix RPN7 PF10602.9 EDO06141.1 - 1.9e-53 180.7 1.8 3.1e-53 180.0 1.8 1.3 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EDO06141.1 - 8.3e-13 48.8 0.4 4.5e-12 46.4 0.1 2.2 2 0 0 2 2 2 1 PCI domain TPR_8 PF13181.6 EDO06141.1 - 2.9 8.3 4.8 1.5 9.3 0.3 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Ribosomal_L22e PF01776.17 EDO06142.1 - 2.6e-46 156.5 1.1 3e-46 156.3 1.1 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family Ints3 PF10189.9 EDO06142.1 - 0.082 12.2 0.0 0.099 11.9 0.0 1.1 1 0 0 1 1 1 0 Integrator complex subunit 3 RRM_1 PF00076.22 EDO06143.1 - 2.4e-17 62.5 0.0 3.4e-17 62.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDO06143.1 - 0.0035 17.2 0.0 0.0055 16.5 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif PWI PF01480.17 EDO06144.1 - 8.2e-10 38.9 0.0 1.7e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 PWI domain RRM_1 PF00076.22 EDO06144.1 - 4.1e-08 32.9 0.0 1.7e-07 30.9 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Histone PF00125.24 EDO06145.1 - 3.2e-54 182.8 1.7 3.5e-54 182.7 1.7 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EDO06145.1 - 0.00038 20.5 0.0 0.00077 19.6 0.0 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EDO06145.1 - 0.00046 20.5 0.0 0.00069 20.0 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 EDO06145.1 - 0.00065 20.3 1.7 0.00082 20.0 1.7 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 EDO06145.1 - 0.0053 17.0 0.0 0.01 16.1 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EDO06145.1 - 0.017 15.2 0.1 0.031 14.3 0.0 1.4 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Histone_H2A_C PF16211.5 EDO06146.1 - 1.8e-16 59.5 0.0 3.2e-16 58.7 0.0 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EDO06146.1 - 4.1e-15 56.3 0.0 5.3e-15 55.9 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EDO06146.1 - 0.0003 21.0 0.0 0.00058 20.1 0.0 1.5 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TPR_2 PF07719.17 EDO06147.1 - 3e-12 45.6 8.5 0.023 14.8 0.0 7.8 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_6 PF13174.6 EDO06147.1 - 5.3e-11 42.4 1.6 1 10.2 0.0 8.0 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDO06147.1 - 8e-11 41.8 5.8 0.88 10.6 0.0 7.5 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_1 PF00515.28 EDO06147.1 - 2.9e-10 39.5 11.1 0.004 16.9 0.1 7.4 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDO06147.1 - 5.5e-09 36.4 10.7 0.00097 19.6 0.1 7.5 8 1 0 8 8 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDO06147.1 - 3.6e-08 33.6 6.0 0.11 12.8 0.0 7.0 6 2 1 8 8 8 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDO06147.1 - 3.6e-07 29.9 8.0 1.8 9.0 0.0 7.4 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDO06147.1 - 1.3e-05 24.8 4.3 3.7 7.8 0.0 7.2 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDO06147.1 - 0.00072 20.2 0.2 1.7 9.4 0.0 5.2 7 0 0 7 7 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 EDO06147.1 - 0.001 18.7 0.0 6.3 6.6 0.0 4.4 5 0 0 5 5 5 1 TPR repeat ANAPC3 PF12895.7 EDO06147.1 - 0.0015 18.7 17.3 1 9.6 0.1 7.2 6 2 2 8 8 8 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EDO06147.1 - 0.003 17.7 0.2 1.1 9.4 0.0 3.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EDO06147.1 - 0.0041 17.4 8.6 1.6 9.3 0.0 6.8 7 0 0 7 7 6 1 Tetratricopeptide repeat TAP42 PF04177.12 EDO06147.1 - 0.0067 15.6 1.1 0.015 14.4 1.1 1.5 1 0 0 1 1 1 1 TAP42-like family HEAT_2 PF13646.6 EDO06147.1 - 0.0091 16.4 0.1 6.6 7.2 0.0 3.3 2 1 1 3 3 3 1 HEAT repeats Alkyl_sulf_dimr PF14863.6 EDO06147.1 - 0.025 15.0 0.3 32 5.0 0.0 3.9 4 0 0 4 4 3 0 Alkyl sulfatase dimerisation TPR_10 PF13374.6 EDO06147.1 - 0.028 14.3 0.0 0.93 9.4 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC5 PF12862.7 EDO06147.1 - 0.078 13.0 1.0 8 6.6 0.0 3.3 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 5 Ribosomal_L19 PF01245.20 EDO06148.1 - 2.8e-15 56.2 0.9 1e-14 54.4 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein L19 Slu7 PF11708.8 EDO06149.1 - 1.2e-56 192.5 1.0 4.6e-53 180.7 1.0 3.0 1 1 0 1 1 1 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.6 EDO06149.1 - 0.053 13.3 0.3 0.12 12.2 0.3 1.6 1 0 0 1 1 1 0 Zinc knuckle DHHC PF01529.20 EDO06150.1 - 1.1e-06 28.7 33.6 1.2e-06 28.7 19.0 3.5 2 2 0 2 2 2 1 DHHC palmitoyltransferase DUF2207 PF09972.9 EDO06150.1 - 3.1 6.5 4.5 6.3 5.4 1.4 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) MACPF PF01823.19 EDO06153.1 - 2.6e-30 106.1 3.3 1.4e-22 80.8 0.4 2.4 1 1 1 2 2 2 2 MAC/Perforin domain MOSC_N PF03476.16 EDO06153.1 - 0.084 12.8 0.1 3.7 7.4 0.0 2.5 3 0 0 3 3 3 0 MOSC N-terminal beta barrel domain RNA_pol_Rpb2_6 PF00562.28 EDO06154.1 - 4.4e-114 381.6 0.1 6e-114 381.1 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EDO06154.1 - 2.3e-30 105.6 0.0 4.1e-30 104.8 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 EDO06154.1 - 8.4e-27 93.2 0.0 2.1e-26 91.9 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.20 EDO06154.1 - 4.1e-21 75.2 0.1 4.1e-20 72.0 0.0 2.7 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 EDO06154.1 - 0.0032 17.1 0.1 0.012 15.3 0.0 2.0 2 1 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 EDO06154.1 - 0.029 14.7 0.1 0.11 12.8 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase Rpb2, domain 4 zf-ribbon_3 PF13248.6 EDO06154.1 - 0.13 11.7 1.1 0.6 9.6 0.1 2.6 2 0 0 2 2 2 0 zinc-ribbon domain RNA_pol_Rpa2_4 PF06883.12 EDO06154.1 - 0.15 12.1 0.0 0.52 10.4 0.0 2.0 1 0 0 1 1 1 0 RNA polymerase I, Rpa2 specific domain Cys_rich_CPXG PF14255.6 EDO06154.1 - 0.22 11.4 1.2 0.54 10.2 1.2 1.6 1 0 0 1 1 1 0 Cysteine-rich CPXCG Zn_ribbon_SprT PF17283.2 EDO06154.1 - 0.43 10.5 2.6 1.3 9.0 2.6 1.8 1 0 0 1 1 1 0 SprT-like zinc ribbon domain PLDc_2 PF13091.6 EDO06156.1 - 2.2e-27 95.5 0.0 3.5e-14 52.8 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EDO06156.1 - 2.1e-11 43.5 4.6 9.9e-05 22.4 0.0 3.0 3 0 0 3 3 3 2 Phospholipase D Active site motif MACPF PF01823.19 EDO06158.1 - 7.4e-29 101.3 0.1 1.9e-28 100.0 0.1 1.6 1 1 0 1 1 1 1 MAC/Perforin domain MRP-L47 PF06984.13 EDO06159.1 - 8.6e-21 73.9 0.2 1.8e-19 69.7 0.0 2.2 2 0 0 2 2 2 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) RNA_pol_Rpb2_6 PF00562.28 EDO06161.1 - 1.5e-120 402.9 0.0 2.2e-120 402.3 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EDO06161.1 - 1.2e-60 204.5 0.0 1.7e-60 204.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EDO06161.1 - 3.1e-48 163.9 0.0 7.2e-48 162.8 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EDO06161.1 - 1.1e-34 118.6 0.2 3e-34 117.3 0.2 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 EDO06161.1 - 3.1e-26 91.3 0.0 6.4e-26 90.3 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.13 EDO06161.1 - 6.9e-21 74.3 0.0 1.9e-20 72.9 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 EDO06161.1 - 3.1e-19 69.3 2.9 8.4e-19 67.9 2.9 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Dr_adhesin PF12393.8 EDO06161.1 - 0.027 14.7 0.9 0.074 13.4 0.9 1.8 1 0 0 1 1 1 0 Dr family adhesin DUF5445 PF17520.2 EDO06162.1 - 0.18 11.7 0.9 0.42 10.5 0.9 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5445) YpmT PF17431.2 EDO06162.1 - 0.2 11.7 6.6 0.056 13.5 2.6 2.2 2 0 0 2 2 2 0 Uncharacterized YmpT-like VIT1 PF01988.19 EDO06163.1 - 5e-41 140.9 0.7 5.8e-41 140.7 0.7 1.0 1 0 0 1 1 1 1 VIT family DUF1129 PF06570.11 EDO06163.1 - 0.033 13.7 2.5 0.42 10.1 1.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Kelch_1 PF01344.25 EDO06164.1 - 7.7e-47 156.6 9.7 1.3e-11 43.9 0.1 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 EDO06164.1 - 2.7e-38 129.7 6.6 1.4e-09 37.8 0.1 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.6 EDO06164.1 - 1.5e-32 110.8 7.6 1.3e-07 31.6 0.0 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 EDO06164.1 - 6.5e-31 105.1 8.5 1e-07 31.7 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_5 PF13854.6 EDO06164.1 - 1.6e-30 104.6 11.5 3e-09 36.7 0.1 6.8 7 0 0 7 7 7 6 Kelch motif Kelch_3 PF13415.6 EDO06164.1 - 3.3e-28 97.4 16.7 4.4e-06 26.8 0.6 7.0 6 1 0 6 6 6 6 Galactose oxidase, central domain BTB PF00651.31 EDO06164.1 - 1.6e-15 57.3 0.4 5.5e-15 55.6 0.1 1.9 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 EDO06164.1 - 0.0086 16.2 0.7 0.18 11.9 0.1 2.4 2 0 0 2 2 2 1 BTB And C-terminal Kelch PEPcase PF00311.17 EDO06165.1 - 5.7e-216 719.2 0.0 6.7e-216 719.0 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxylase PEPcase_2 PF14010.6 EDO06165.1 - 0.00015 20.4 0.0 0.00022 19.9 0.0 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxylase ATG16 PF08614.11 EDO06166.1 - 0.0077 16.5 7.7 0.0077 16.5 7.7 8.5 7 4 2 8 8 8 4 Autophagy protein 16 (ATG16) Csm1_N PF18504.1 EDO06166.1 - 0.035 14.4 0.3 0.035 14.4 0.3 10.3 10 4 2 12 12 12 0 Csm1 N-terminal domain DUF5082 PF16888.5 EDO06166.1 - 0.066 13.5 0.1 0.066 13.5 0.1 9.2 8 1 1 9 9 9 0 Domain of unknown function (DUF5082) APG6_N PF17675.1 EDO06166.1 - 0.39 11.2 81.1 0.051 14.1 5.3 9.1 7 3 1 8 8 8 0 Apg6 coiled-coil region TAFH PF07531.14 EDO06166.1 - 0.47 10.6 5.3 12 6.0 0.6 4.0 3 0 0 3 3 3 0 NHR1 homology to TAF NPV_P10 PF05531.12 EDO06166.1 - 3.1 8.3 19.1 27 5.3 0.0 7.6 7 1 0 7 7 7 0 Nucleopolyhedrovirus P10 protein TMF_TATA_bd PF12325.8 EDO06166.1 - 3.4 7.9 82.9 0.095 12.9 2.7 10.0 9 1 1 10 10 10 0 TATA element modulatory factor 1 TATA binding Rootletin PF15035.6 EDO06166.1 - 5.2 7.0 72.0 0.055 13.5 2.3 8.2 6 1 1 8 8 8 0 Ciliary rootlet component, centrosome cohesion FAST_1 PF06743.15 EDO06167.1 - 0.024 14.6 0.6 3.4 7.7 0.0 4.0 3 1 0 3 3 3 0 FAST kinase-like protein, subdomain 1 HHV6-IE PF03753.13 EDO06167.1 - 0.079 10.4 0.0 0.11 10.0 0.0 1.1 1 0 0 1 1 1 0 Human herpesvirus 6 immediate early protein UCR_hinge PF02320.16 EDO06170.1 - 1.6e-24 85.9 3.3 2.2e-24 85.4 3.3 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein PRP3 PF08572.10 EDO06171.1 - 1.1e-63 215.0 13.0 1.1e-63 215.0 13.0 2.1 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 EDO06171.1 - 7.1e-32 110.5 0.2 7.1e-32 110.5 0.2 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF1115) Ribosomal_L22e PF01776.17 EDO06171.1 - 9.8 6.6 9.0 18 5.8 0.1 3.7 4 1 1 5 5 5 0 Ribosomal L22e protein family HORMA PF02301.18 EDO06172.1 - 1.4e-52 178.4 0.0 2e-52 177.9 0.0 1.3 1 0 0 1 1 1 1 HORMA domain Gar1 PF04410.14 EDO06173.1 - 1.4e-32 112.6 0.0 1.7e-32 112.3 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region Keratin_2_head PF16208.5 EDO06173.1 - 6.2 6.9 24.6 0.54 10.4 6.3 2.1 2 0 0 2 2 2 0 Keratin type II head FtsJ PF01728.19 EDO06174.1 - 3.6e-54 183.6 0.1 4.3e-54 183.3 0.1 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 EDO06174.1 - 0.0061 16.4 0.3 0.11 12.2 0.3 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDO06174.1 - 0.0063 16.4 0.0 0.0078 16.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain NSP16 PF06460.12 EDO06174.1 - 0.12 11.4 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Coronavirus NSP16 Thioredoxin_8 PF13905.6 EDO06175.1 - 3.6e-49 165.0 0.6 1.4e-24 86.2 0.2 2.7 3 0 0 3 3 3 2 Thioredoxin-like Head-tail_con PF12236.8 EDO06175.1 - 0.13 10.6 0.1 0.37 9.2 0.0 1.7 2 0 0 2 2 2 0 Bacteriophage head to tail connecting protein CDC45 PF02724.14 EDO06177.1 - 0.2 9.9 5.9 0.2 9.9 5.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 EDO06177.1 - 0.27 9.9 4.3 0.28 9.9 4.3 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 EDO06177.1 - 1 8.5 4.5 1.1 8.4 4.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4100 PF13352.6 EDO06177.1 - 6.3 6.5 17.8 9 6.0 17.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4100) NPR3 PF03666.13 EDO06177.1 - 9 5.0 12.0 11 4.7 12.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Cnd1 PF12717.7 EDO06178.1 - 1.9e-31 109.3 6.7 1e-30 106.9 0.2 3.3 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EDO06178.1 - 2.1e-05 23.3 1.2 2.1e-05 23.3 1.2 3.3 3 1 0 3 3 3 2 Adaptin N terminal region Nipped-B_C PF12830.7 EDO06178.1 - 0.11 12.4 7.7 0.34 10.8 0.1 4.0 4 1 0 4 4 4 0 Sister chromatid cohesion C-terminus XRN_M PF17846.1 EDO06179.1 - 3.7e-107 359.0 0.2 3.7e-107 359.0 0.2 2.1 2 1 1 3 3 3 1 Xrn1 helical domain XRN_N PF03159.18 EDO06179.1 - 9.9e-97 323.1 0.2 2.1e-96 322.0 0.0 1.7 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus VWA_2 PF13519.6 EDO06180.1 - 1.5e-13 51.3 0.0 4.1e-13 49.9 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain V-ATPase_H_C PF11698.8 EDO06180.1 - 0.035 14.2 0.3 0.24 11.5 0.1 2.3 1 1 1 2 2 2 0 V-ATPase subunit H Di19_C PF14571.6 EDO06180.1 - 0.11 13.1 0.6 1.1 9.8 0.2 2.3 2 0 0 2 2 2 0 Stress-induced protein Di19, C-terminal SPACA9 PF15120.6 EDO06180.1 - 0.16 11.8 2.1 1.7 8.4 0.1 2.2 2 0 0 2 2 2 0 Sperm acrosome-associated protein 9 tRNA-synt_1b PF00579.25 EDO06181.1 - 1.9e-47 162.0 0.0 3e-47 161.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) VESA1_N PF12785.7 EDO06182.1 - 8.7e-196 651.3 21.2 8.7e-196 651.3 21.2 2.8 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 DUF2524 PF10732.9 EDO06182.1 - 2.4e-06 27.7 0.1 0.065 13.5 0.0 3.0 2 0 0 2 2 2 2 Protein of unknown function (DUF2524) Jnk-SapK_ap_N PF09744.9 EDO06182.1 - 0.0038 17.5 4.4 0.013 15.7 4.2 2.0 1 1 1 2 2 2 1 JNK_SAPK-associated protein-1 Spc7 PF08317.11 EDO06182.1 - 0.045 12.6 8.2 0.095 11.6 7.4 1.8 1 1 1 2 2 2 0 Spc7 kinetochore protein MnmE_helical PF12631.7 EDO06182.1 - 0.051 13.7 0.2 0.16 12.1 0.2 1.8 1 0 0 1 1 1 0 MnmE helical domain TPR_MLP1_2 PF07926.12 EDO06182.1 - 0.074 13.1 8.2 0.54 10.3 4.8 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein LXG PF04740.12 EDO06182.1 - 0.08 12.6 2.4 2.3 7.9 0.1 2.7 1 1 1 2 2 2 0 LXG domain of WXG superfamily DUF4085 PF13315.6 EDO06182.1 - 0.087 12.4 0.4 0.15 11.6 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) Lac_bphage_repr PF06543.12 EDO06182.1 - 0.13 12.3 0.2 0.34 10.9 0.2 1.7 1 0 0 1 1 1 0 Lactococcus bacteriophage repressor DUF3391 PF11871.8 EDO06182.1 - 0.14 12.7 0.3 0.29 11.7 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) MIP-T3_C PF17749.1 EDO06182.1 - 0.14 12.1 2.8 0.29 11.1 2.8 1.4 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 C-terminal region COG2 PF06148.11 EDO06182.1 - 0.26 11.4 2.1 0.85 9.7 0.1 2.5 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Prefoldin_2 PF01920.20 EDO06182.1 - 0.44 10.5 12.3 2.1 8.3 7.3 3.3 2 2 0 2 2 2 0 Prefoldin subunit DUF1664 PF07889.12 EDO06182.1 - 0.46 10.5 3.2 9 6.4 0.1 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) YkyA PF10368.9 EDO06182.1 - 6.4 6.4 11.6 0.72 9.5 3.3 2.6 3 0 0 3 3 3 0 Putative cell-wall binding lipoprotein VESA1_N PF12785.7 EDO06183.1 - 2e-224 745.7 21.9 2e-224 745.7 21.9 2.5 2 0 0 2 2 2 1 Variant erythrocyte surface antigen-1 Chordopox_A30L PF06015.12 EDO06183.1 - 0.027 14.3 0.0 0.083 12.7 0.0 1.7 1 0 0 1 1 1 0 Chordopoxvirus A30L protein Spc7 PF08317.11 EDO06183.1 - 4.3 6.1 5.4 49 2.6 5.4 2.3 1 1 0 1 1 1 0 Spc7 kinetochore protein F-box-like_2 PF13013.6 EDO06184.1 - 1.1e-13 51.0 6.0 1.5e-05 24.9 0.1 4.6 2 2 3 5 5 5 4 F-box-like domain GIY-YIG PF01541.24 EDO06184.1 - 0.01 16.1 0.1 0.71 10.2 0.0 2.5 2 0 0 2 2 2 0 GIY-YIG catalytic domain DUF2014 PF09427.10 EDO06184.1 - 0.13 11.6 0.0 13 5.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF2014) SpoVG PF04026.12 EDO06184.1 - 0.19 11.9 0.4 2.4 8.4 0.1 2.4 2 0 0 2 2 2 0 SpoVG F-box-like_2 PF13013.6 EDO06185.1 - 0.098 12.6 0.3 0.19 11.7 0.3 1.4 1 0 0 1 1 1 0 F-box-like domain VESA1_N PF12785.7 EDO06186.1 - 2.5e-207 689.3 19.8 2.5e-207 689.3 19.8 2.8 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 DUF2524 PF10732.9 EDO06186.1 - 2.6e-06 27.6 0.1 0.067 13.5 0.0 3.0 2 0 0 2 2 2 2 Protein of unknown function (DUF2524) Jnk-SapK_ap_N PF09744.9 EDO06186.1 - 0.0039 17.4 4.4 0.013 15.7 4.2 2.0 1 1 1 2 2 2 1 JNK_SAPK-associated protein-1 Spc7 PF08317.11 EDO06186.1 - 0.046 12.6 8.2 0.095 11.6 7.4 1.8 1 1 1 2 2 2 0 Spc7 kinetochore protein MnmE_helical PF12631.7 EDO06186.1 - 0.05 13.8 0.2 0.16 12.1 0.2 1.8 1 0 0 1 1 1 0 MnmE helical domain TPR_MLP1_2 PF07926.12 EDO06186.1 - 0.077 13.1 8.2 0.56 10.3 4.8 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein LXG PF04740.12 EDO06186.1 - 0.079 12.7 2.4 2.4 7.8 0.1 2.7 1 1 1 2 2 2 0 LXG domain of WXG superfamily DUF4085 PF13315.6 EDO06186.1 - 0.09 12.4 0.4 0.16 11.6 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) DUF3391 PF11871.8 EDO06186.1 - 0.15 12.6 0.3 0.3 11.6 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) MIP-T3_C PF17749.1 EDO06186.1 - 0.15 12.0 2.8 0.3 11.0 2.8 1.4 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 C-terminal region COG2 PF06148.11 EDO06186.1 - 0.24 11.5 1.9 0.89 9.6 0.1 2.5 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Lac_bphage_repr PF06543.12 EDO06186.1 - 0.26 11.3 1.7 0.35 10.9 0.2 2.0 2 0 0 2 2 1 0 Lactococcus bacteriophage repressor DUF1664 PF07889.12 EDO06186.1 - 0.42 10.7 3.1 9.2 6.3 0.1 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) HsbA PF12296.8 EDO06186.1 - 0.42 11.0 1.3 1.9 9.0 0.1 2.7 2 1 1 3 3 3 0 Hydrophobic surface binding protein A Prefoldin_2 PF01920.20 EDO06186.1 - 0.43 10.6 12.3 2.2 8.3 7.3 3.4 2 2 0 2 2 2 0 Prefoldin subunit DUF2959 PF11172.8 EDO06186.1 - 0.7 10.0 2.1 4.5 7.4 1.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2959) Baculo_PEP_C PF04513.12 EDO06186.1 - 2.3 8.2 3.5 13 5.8 0.1 3.5 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus YkyA PF10368.9 EDO06186.1 - 6.8 6.3 11.6 0.74 9.5 3.3 2.7 3 0 0 3 3 3 0 Putative cell-wall binding lipoprotein VESA1_N PF12785.7 EDO06187.1 - 1.1e-28 100.4 15.5 1.7e-25 89.9 10.1 3.2 1 1 1 2 2 2 2 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO06188.1 - 2e-183 610.5 47.2 2e-183 610.5 47.2 4.2 3 1 0 3 3 3 1 Variant erythrocyte surface antigen-1 Baculo_PEP_C PF04513.12 EDO06188.1 - 0.0076 16.3 0.8 0.12 12.5 0.9 2.8 1 1 1 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4175 PF13779.6 EDO06188.1 - 0.023 12.6 3.3 0.39 8.6 1.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4175) HOOK PF05622.12 EDO06188.1 - 0.18 10.0 1.4 0.22 9.6 0.3 1.6 2 0 0 2 2 2 0 HOOK protein DUF1664 PF07889.12 EDO06188.1 - 0.19 11.8 1.2 4.6 7.3 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Mt_ATP_synt PF15704.5 EDO06188.1 - 2.3 8.1 10.1 0.18 11.7 3.2 2.2 2 0 0 2 2 2 0 Mitochondrial ATP synthase subunit Proteasome PF00227.26 EDO06189.1 - 1.1e-25 90.3 0.1 2e-25 89.4 0.1 1.4 1 1 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDO06189.1 - 2.9e-13 49.2 0.0 5.1e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Peptidase_S9 PF00326.21 EDO06190.1 - 2.5e-22 79.4 0.0 3.7e-22 78.8 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EDO06190.1 - 0.074 12.6 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DSHCT PF08148.12 EDO06191.1 - 4.7e-45 153.2 0.0 1e-44 152.1 0.0 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 EDO06191.1 - 4.8e-19 68.8 0.0 7.5e-18 64.9 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EDO06191.1 - 5e-09 36.4 0.1 3.2e-08 33.7 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit rRNA_proc-arch PF13234.6 EDO06191.1 - 2.7e-07 30.8 3.8 5.9e-07 29.7 3.8 1.5 1 0 0 1 1 1 1 rRNA-processing arch domain Helicase_C PF00271.31 EDO06191.1 - 2.7e-06 27.7 0.2 2.8e-05 24.4 0.2 2.7 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ATPase_2 PF01637.18 EDO06191.1 - 0.011 15.6 0.0 0.057 13.3 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea DUF5343 PF17278.2 EDO06191.1 - 0.02 15.0 0.4 0.059 13.5 0.0 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5343) IBN_N PF03810.19 EDO06192.1 - 9.1e-06 25.5 0.2 0.00016 21.5 0.2 3.1 3 0 0 3 3 3 1 Importin-beta N-terminal domain IF4E PF01652.18 EDO06192.1 - 0.052 13.3 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Eukaryotic initiation factor 4E WD40 PF00400.32 EDO06193.1 - 0.00058 20.6 7.1 0.0048 17.7 0.0 4.8 8 0 0 8 8 8 1 WD domain, G-beta repeat PGDYG PF14083.6 EDO06193.1 - 0.14 12.4 0.0 2.1 8.6 0.0 2.4 2 0 0 2 2 2 0 PGDYG protein DUF974 PF06159.13 EDO06194.1 - 0.0025 17.6 0.3 0.0056 16.5 0.3 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF974) MFAP1 PF06991.11 EDO06195.1 - 8.5e-65 218.6 21.5 8.5e-65 218.6 21.5 2.3 1 1 1 2 2 2 1 Microfibril-associated/Pre-mRNA processing DUF2362 PF10154.9 EDO06196.1 - 0.00049 19.2 0.0 0.0034 16.4 0.0 2.3 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2362) LSM PF01423.22 EDO06197.1 - 6.5e-16 57.8 0.6 7.8e-16 57.5 0.6 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EDO06197.1 - 0.014 15.5 0.0 0.019 15.1 0.0 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain LSM14 PF12701.7 EDO06197.1 - 0.076 13.1 0.1 0.75 9.9 0.1 2.1 1 1 0 1 1 1 0 Scd6-like Sm domain 2OG-FeII_Oxy_5 PF13759.6 EDO06197.1 - 0.078 13.4 0.0 0.09 13.2 0.0 1.1 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase RINGv PF12906.7 EDO06198.1 - 1.4e-12 47.5 3.2 3e-12 46.4 3.2 1.6 1 0 0 1 1 1 1 RING-variant domain FHA PF00498.26 EDO06198.1 - 5e-10 39.6 0.2 5.8e-09 36.2 0.4 2.4 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 EDO06198.1 - 1.7e-07 31.5 0.0 1.4e-06 28.5 0.0 2.1 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain zf-RING_2 PF13639.6 EDO06198.1 - 0.83 10.0 3.9 0.29 11.5 0.9 1.8 2 0 0 2 2 2 0 Ring finger domain FAST_1 PF06743.15 EDO06199.1 - 0.003 17.5 13.3 0.17 11.8 0.2 5.4 3 3 1 5 5 5 3 FAST kinase-like protein, subdomain 1 tRNA_lig_CPD PF08302.11 EDO06201.1 - 0.0001 21.8 0.0 0.00025 20.6 0.0 1.6 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain RabGAP-TBC PF00566.18 EDO06202.1 - 4.8e-50 170.2 0.9 6.6e-50 169.7 0.9 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain NqrM PF04400.13 EDO06202.1 - 1.8 8.4 4.9 3.3 7.6 4.9 1.4 1 0 0 1 1 1 0 (Na+)-NQR maturation NqrM WD40 PF00400.32 EDO06204.1 - 7.9e-06 26.5 1.9 1.2 10.1 0.1 5.9 4 0 0 4 4 4 2 WD domain, G-beta repeat DUF4234 PF14018.6 EDO06204.1 - 0.049 13.7 0.1 0.15 12.2 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4234) Prismane PF03063.20 EDO06205.1 - 0.047 12.4 2.6 0.046 12.4 1.7 1.3 1 1 0 1 1 1 0 Prismane/CO dehydrogenase family Acetyltransf_11 PF13720.6 EDO06205.1 - 0.14 12.7 0.4 0.28 11.7 0.4 1.5 1 0 0 1 1 1 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 DUF2981 PF11200.8 EDO06205.1 - 0.58 9.8 5.4 0.65 9.7 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Rep_fac_C PF08542.11 EDO06206.1 - 2.1e-16 60.1 0.0 7.7e-16 58.3 0.0 2.0 2 0 0 2 2 1 1 Replication factor C C-terminal domain AAA PF00004.29 EDO06206.1 - 1.1e-14 55.0 0.0 2e-14 54.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EDO06206.1 - 4.3e-14 52.6 0.0 1.2e-12 47.9 0.0 2.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EDO06206.1 - 2.8e-07 30.7 0.0 6e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 EDO06206.1 - 5.9e-07 29.8 0.3 2.8e-05 24.4 0.1 2.8 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EDO06206.1 - 3.2e-06 27.6 0.0 4.7e-05 23.8 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 EDO06206.1 - 3.3e-06 27.0 0.0 6.3e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 EDO06206.1 - 1e-05 25.8 0.0 2.8e-05 24.3 0.0 1.9 1 1 0 1 1 1 1 AAA C-terminal domain AAA_19 PF13245.6 EDO06206.1 - 5.9e-05 23.4 0.4 0.00041 20.7 0.0 2.4 2 2 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EDO06206.1 - 8.1e-05 22.5 0.1 0.00027 20.8 0.1 1.7 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EDO06206.1 - 0.00023 21.2 0.0 0.0007 19.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TniB PF05621.11 EDO06206.1 - 0.00058 19.3 0.0 0.052 13.0 0.0 2.3 2 0 0 2 2 2 1 Bacterial TniB protein RuvB_N PF05496.12 EDO06206.1 - 0.00097 18.9 0.0 0.0048 16.7 0.0 2.2 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 EDO06206.1 - 0.0021 17.5 0.0 0.0043 16.4 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EDO06206.1 - 0.0021 18.1 0.0 0.0042 17.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EDO06206.1 - 0.0025 17.1 0.0 0.0048 16.2 0.0 1.4 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 EDO06206.1 - 0.0035 17.4 0.0 0.076 13.0 0.0 2.1 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDO06206.1 - 0.013 15.3 0.1 0.1 12.4 0.0 2.2 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_24 PF13479.6 EDO06206.1 - 0.014 15.1 0.0 0.04 13.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EDO06206.1 - 0.019 15.5 0.1 0.044 14.3 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_3 PF07726.11 EDO06206.1 - 0.019 14.8 0.0 0.054 13.4 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EDO06206.1 - 0.02 14.4 0.0 0.035 13.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_2 PF07724.14 EDO06206.1 - 0.039 14.1 0.0 0.17 12.0 0.0 2.1 1 1 2 3 3 3 0 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 EDO06206.1 - 0.056 12.6 0.0 0.093 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) MCM PF00493.23 EDO06206.1 - 0.067 12.3 0.0 0.15 11.1 0.0 1.5 1 0 0 1 1 1 0 MCM P-loop domain Torsin PF06309.11 EDO06206.1 - 0.08 13.0 0.0 0.4 10.8 0.0 2.0 2 0 0 2 2 2 0 Torsin AAA_29 PF13555.6 EDO06206.1 - 0.097 12.4 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_27 PF13514.6 EDO06206.1 - 0.11 12.1 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDO06206.1 - 0.19 12.1 0.3 0.9 10.0 0.1 2.3 2 1 0 2 2 2 0 RNA helicase AAA PF00004.29 EDO06207.1 - 1.3e-10 41.8 0.1 1.4e-08 35.2 0.0 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDO06207.1 - 2.7e-05 24.5 0.0 0.00091 19.5 0.0 2.9 3 1 0 3 3 3 1 AAA domain AAA_14 PF13173.6 EDO06207.1 - 0.0002 21.4 0.0 0.0081 16.2 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 EDO06207.1 - 0.00087 19.7 0.0 0.78 10.1 0.0 3.3 3 0 0 3 3 3 1 AAA ATPase domain AAA_25 PF13481.6 EDO06207.1 - 0.0011 18.6 0.1 0.57 9.7 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_23 PF13476.6 EDO06207.1 - 0.0019 18.7 0.6 0.0019 18.7 0.6 2.7 2 1 0 3 3 3 1 AAA domain AAA_29 PF13555.6 EDO06207.1 - 0.0034 17.1 0.0 0.0079 15.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 EDO06207.1 - 0.0041 16.5 0.0 0.0073 15.7 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_15 PF13175.6 EDO06207.1 - 0.0089 15.8 0.0 0.0089 15.8 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 EDO06207.1 - 0.015 15.4 0.1 0.041 14.0 0.0 2.0 2 1 0 2 2 2 0 50S ribosome-binding GTPase ATPase_2 PF01637.18 EDO06207.1 - 0.029 14.3 0.5 0.19 11.6 0.0 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea MobB PF03205.14 EDO06207.1 - 0.032 14.1 0.0 0.085 12.8 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B ABC_ATPase PF09818.9 EDO06207.1 - 0.035 12.9 0.0 0.061 12.1 0.0 1.3 1 0 0 1 1 1 0 Predicted ATPase of the ABC class NACHT PF05729.12 EDO06207.1 - 0.075 12.9 1.2 0.19 11.6 0.1 2.2 3 0 0 3 3 3 0 NACHT domain T2SSE PF00437.20 EDO06207.1 - 0.11 11.5 0.0 0.27 10.3 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein IF3_C PF00707.22 EDO06208.1 - 2.6e-05 24.1 0.0 7.4e-05 22.6 0.0 1.8 2 0 0 2 2 2 1 Translation initiation factor IF-3, C-terminal domain Gp_dh_C PF02800.20 EDO06209.1 - 2.3e-67 225.5 0.0 3.1e-67 225.1 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 EDO06209.1 - 4.1e-37 126.6 0.0 8.7e-37 125.5 0.0 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain ADH_zinc_N PF00107.26 EDO06209.1 - 0.00058 19.8 0.0 0.0014 18.6 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DapB_N PF01113.20 EDO06209.1 - 0.02 15.0 0.0 0.072 13.2 0.0 2.0 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus 2-Hacid_dh_C PF02826.19 EDO06209.1 - 0.15 11.4 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Cytochrom_C1 PF02167.15 EDO06210.1 - 9.9e-95 316.4 0.0 1.6e-94 315.7 0.0 1.3 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 EDO06210.1 - 0.0041 17.4 0.1 0.011 16.0 0.1 1.8 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 EDO06210.1 - 0.02 16.0 0.0 0.078 14.1 0.0 2.1 1 0 0 1 1 1 0 Cytochrome c zf-C2H2_jaz PF12171.8 EDO06211.1 - 7.5e-08 32.5 1.4 1.4e-07 31.6 1.4 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDO06211.1 - 7.6e-07 29.3 1.6 1.5e-06 28.4 1.6 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-U1 PF06220.12 EDO06211.1 - 0.00043 20.0 0.8 0.0012 18.5 0.8 1.8 1 0 0 1 1 1 1 U1 zinc finger Med9 PF07544.13 EDO06211.1 - 0.005 16.9 5.5 0.0055 16.8 3.9 1.9 2 0 0 2 2 2 1 RNA polymerase II transcription mediator complex subunit 9 DUF4349 PF14257.6 EDO06211.1 - 0.005 16.3 0.6 0.0077 15.7 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4349) DDE_Tnp_IS240 PF13610.6 EDO06211.1 - 0.0062 16.8 2.6 0.01 16.1 2.6 1.4 1 0 0 1 1 1 1 DDE domain zf-C2H2_2 PF12756.7 EDO06211.1 - 0.013 15.9 1.1 0.013 15.9 1.1 1.8 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf_C2H2_ZHX PF18387.1 EDO06211.1 - 0.048 13.3 0.1 0.11 12.2 0.1 1.6 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF5093 PF17011.5 EDO06211.1 - 0.077 13.3 5.0 0.097 13.0 4.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF5093) DUF1411 PF07199.11 EDO06212.1 - 1.8e-93 311.6 0.0 2.3e-93 311.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1411) DUF1411 PF07199.11 EDO06213.1 - 2.2e-92 308.1 1.4 3e-92 307.6 1.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1411) Rep_3 PF01051.21 EDO06213.1 - 0.013 15.3 0.2 0.17 11.7 0.0 2.0 1 1 1 2 2 2 0 Initiator Replication protein AbbA_antirepres PF14156.6 EDO06213.1 - 0.1 12.5 0.1 0.27 11.1 0.1 1.7 1 0 0 1 1 1 0 Antirepressor AbbA DUF1411 PF07199.11 EDO06214.1 - 1.7e-74 249.7 9.2 4.7e-55 186.3 0.2 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF1411) CDC73_C PF05179.14 EDO06215.1 - 7e-43 146.0 0.2 1.1e-42 145.4 0.2 1.3 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal NUDIX PF00293.28 EDO06216.1 - 5e-19 68.7 0.0 5.7e-19 68.5 0.0 1.0 1 0 0 1 1 1 1 NUDIX domain Armet PF10208.9 EDO06216.1 - 0.033 14.1 0.0 0.043 13.8 0.0 1.2 1 0 0 1 1 1 0 Degradation arginine-rich protein for mis-folding Endothelin PF00322.17 EDO06216.1 - 0.41 10.3 0.1 0.41 10.3 0.1 1.9 3 0 0 3 3 3 0 Endothelin family LSM PF01423.22 EDO06217.1 - 7e-12 44.9 0.0 9.4e-12 44.5 0.0 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EDO06217.1 - 0.037 13.7 0.0 0.063 12.9 0.0 1.3 1 0 0 1 1 1 0 Hfq protein VGCC_beta4Aa_N PF12052.8 EDO06217.1 - 0.046 13.8 0.0 0.074 13.2 0.0 1.4 1 0 0 1 1 1 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal LSM14 PF12701.7 EDO06217.1 - 0.072 13.2 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Scd6-like Sm domain VWA PF00092.28 EDO06218.1 - 2.1e-11 44.4 1.0 0.00019 21.7 0.1 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain TSP_1 PF00090.19 EDO06218.1 - 0.0091 16.2 24.4 0.27 11.5 6.8 3.8 2 2 0 2 2 2 2 Thrombospondin type 1 domain DUF4384 PF14326.6 EDO06218.1 - 0.1 12.8 0.0 5 7.3 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4384) YidD PF01809.18 EDO06218.1 - 0.1 12.5 1.3 12 5.9 0.0 2.4 2 0 0 2 2 2 0 Putative membrane protein insertion efficiency factor Late_protein_L1 PF00500.18 EDO06219.1 - 0.032 13.0 0.0 0.04 12.7 0.0 1.1 1 0 0 1 1 1 0 L1 (late) protein VWA PF00092.28 EDO06220.1 - 1.7e-24 87.0 0.0 2.6e-24 86.4 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EDO06220.1 - 4.3e-08 33.8 0.0 8.8e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF4366 PF14283.6 EDO06220.1 - 0.032 14.3 1.2 0.085 12.9 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) TSP_1 PF00090.19 EDO06220.1 - 1.4 9.2 5.2 4.4 7.6 5.2 1.9 1 1 0 1 1 1 0 Thrombospondin type 1 domain S4 PF01479.25 EDO06222.1 - 7.7e-12 44.7 1.1 1.3e-11 44.0 0.2 1.9 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 EDO06222.1 - 6.2e-06 27.0 1.5 1.3e-05 26.1 0.6 1.9 1 1 1 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain SPT16 PF08644.11 EDO06224.1 - 1.7e-50 171.1 0.9 1.7e-50 171.1 0.9 2.5 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) Peptidase_M24 PF00557.24 EDO06224.1 - 5e-22 78.6 0.1 1.2e-21 77.4 0.0 1.7 2 0 0 2 2 2 1 Metallopeptidase family M24 Rtt106 PF08512.12 EDO06224.1 - 2.5e-13 50.2 1.3 1.8e-12 47.5 0.0 3.0 4 0 0 4 4 4 1 Histone chaperone Rttp106-like RRM_1 PF00076.22 EDO06225.1 - 1.2e-29 101.9 0.0 2.1e-17 62.7 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EDO06225.1 - 0.0035 17.3 0.1 0.89 9.6 0.0 2.2 2 0 0 2 2 2 2 RNA binding motif RRM_7 PF16367.5 EDO06225.1 - 0.034 14.3 0.0 0.079 13.1 0.0 1.7 1 1 0 1 1 1 0 RNA recognition motif ALS2CR8 PF15299.6 EDO06226.1 - 0.058 13.3 1.2 0.24 11.3 1.2 2.0 1 1 0 1 1 1 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 z-alpha PF02295.17 EDO06226.1 - 0.29 11.2 1.6 23 5.1 0.1 2.5 2 0 0 2 2 2 0 Adenosine deaminase z-alpha domain Proteasome PF00227.26 EDO06227.1 - 1e-33 116.4 0.3 1.2e-33 116.2 0.3 1.0 1 0 0 1 1 1 1 Proteasome subunit UME PF08064.13 EDO06227.1 - 0.042 13.8 0.1 0.096 12.6 0.1 1.5 1 0 0 1 1 1 0 UME (NUC010) domain Cyclin PF08613.11 EDO06228.1 - 4e-29 102.1 2.8 6.1e-29 101.5 2.8 1.2 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EDO06228.1 - 1.5e-11 44.1 0.3 2.5e-11 43.4 0.3 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain ATP-synt_C PF00137.21 EDO06229.1 - 1.6e-31 108.4 30.3 1.3e-18 67.0 10.5 2.2 2 0 0 2 2 2 2 ATP synthase subunit C DUF998 PF06197.13 EDO06229.1 - 0.35 10.5 17.7 0.076 12.6 13.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF998) DUF4389 PF14333.6 EDO06229.1 - 3.1 7.8 7.7 1.5 8.8 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4389) Ribosomal_L14 PF00238.19 EDO06230.1 - 2e-16 60.2 1.1 2.5e-16 59.9 1.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e SLBP_RNA_bind PF15247.6 EDO06231.1 - 6.7e-19 67.8 1.2 6.7e-19 67.8 1.2 2.0 2 0 0 2 2 2 1 Histone RNA hairpin-binding protein RNA-binding domain tRNA-synt_1d PF00750.19 EDO06233.1 - 3.9e-105 351.6 0.2 4.8e-105 351.3 0.2 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EDO06233.1 - 4.1e-22 78.6 0.1 3.8e-21 75.5 0.0 2.3 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 EDO06233.1 - 2.7e-17 63.1 0.1 1.8e-16 60.5 0.0 2.4 3 0 0 3 3 3 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1e PF01406.19 EDO06233.1 - 0.0085 15.5 0.0 0.016 14.5 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1 PF00133.22 EDO06233.1 - 0.043 12.1 0.0 0.065 11.5 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) SLIDE PF09111.10 EDO06233.1 - 0.13 12.3 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 SLIDE PI3_PI4_kinase PF00454.27 EDO06234.1 - 3.3e-25 89.3 0.6 1.5e-21 77.4 0.0 2.8 3 0 0 3 3 3 2 Phosphatidylinositol 3- and 4-kinase DUF4135 PF13575.6 EDO06234.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) DUF4383 PF14325.6 EDO06234.1 - 0.11 12.7 0.1 0.27 11.5 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4383) Ribosomal_L13 PF00572.18 EDO06235.1 - 3e-10 40.4 2.2 2.1e-08 34.5 0.1 2.9 2 1 0 2 2 2 1 Ribosomal protein L13 DSBA PF01323.20 EDO06235.1 - 0.062 13.1 0.0 1.4 8.6 0.0 2.1 1 1 1 2 2 2 0 DSBA-like thioredoxin domain Syntaxin PF00804.25 EDO06236.1 - 0.0022 17.7 8.0 0.035 13.8 1.4 2.3 1 1 1 2 2 2 2 Syntaxin Myb_DNA-bind_5 PF13873.6 EDO06236.1 - 0.021 14.9 0.2 6.6 6.9 0.0 2.6 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain SNARE PF05739.19 EDO06236.1 - 0.021 14.8 0.5 0.021 14.8 0.5 2.3 2 0 0 2 2 2 0 SNARE domain Syntaxin_2 PF14523.6 EDO06236.1 - 0.047 14.1 3.6 0.68 10.3 0.3 3.3 2 2 0 2 2 2 0 Syntaxin-like protein Lipase_GDSL_3 PF14606.6 EDO06236.1 - 0.11 12.6 1.1 0.39 10.8 0.0 2.4 1 1 1 3 3 3 0 GDSL-like Lipase/Acylhydrolase family SlyX PF04102.12 EDO06236.1 - 0.86 10.3 4.4 0.37 11.5 0.9 2.3 3 0 0 3 3 3 0 SlyX DUF1411 PF07199.11 EDO06237.1 - 6e-98 326.2 0.0 8.4e-98 325.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1411) DUF1411 PF07199.11 EDO06238.1 - 2.3e-100 334.1 0.0 4e-100 333.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1411) RasGAP_C PF03836.15 EDO06238.1 - 0.00045 20.4 0.9 0.00073 19.7 0.9 1.3 1 0 0 1 1 1 1 RasGAP C-terminus MID_MedPIWI PF18296.1 EDO06238.1 - 0.38 10.5 2.0 0.31 10.8 0.7 1.5 2 0 0 2 2 2 0 MID domain of medPIWI CDC73_C PF05179.14 EDO06239.1 - 7.6e-43 145.9 0.2 1.1e-42 145.3 0.2 1.3 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal NUDIX PF00293.28 EDO06240.1 - 4.4e-18 65.6 0.0 5.1e-18 65.4 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain Endothelin PF00322.17 EDO06240.1 - 0.41 10.3 0.1 0.41 10.3 0.1 1.8 3 0 0 3 3 3 0 Endothelin family LSM PF01423.22 EDO06241.1 - 7e-12 44.9 0.0 9.4e-12 44.5 0.0 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EDO06241.1 - 0.037 13.7 0.0 0.063 12.9 0.0 1.3 1 0 0 1 1 1 0 Hfq protein VGCC_beta4Aa_N PF12052.8 EDO06241.1 - 0.046 13.8 0.0 0.074 13.2 0.0 1.4 1 0 0 1 1 1 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal LSM14 PF12701.7 EDO06241.1 - 0.072 13.2 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Scd6-like Sm domain VWA PF00092.28 EDO06242.1 - 3e-05 24.4 0.0 0.00013 22.3 0.0 2.0 1 1 0 1 1 1 1 von Willebrand factor type A domain Fungus-induced PF10917.8 EDO06242.1 - 0.025 14.9 0.8 6.8 7.1 0.0 2.5 2 0 0 2 2 2 0 Fungus-induced protein DUF1411 PF07199.11 EDO06243.1 - 1.3e-135 449.1 0.3 1.4e-104 347.9 0.4 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1411) AF-4 PF05110.13 EDO06243.1 - 0.059 11.5 20.9 0.078 11.1 20.9 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein IMUP PF15761.5 EDO06243.1 - 0.085 13.6 7.5 0.18 12.5 7.5 1.4 1 0 0 1 1 1 0 Immortalisation up-regulated protein SR-25 PF10500.9 EDO06243.1 - 0.26 10.9 7.5 0.44 10.1 7.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TFIIF_alpha PF05793.12 EDO06243.1 - 0.7 8.4 11.5 1.1 7.8 11.5 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Na_trans_assoc PF06512.13 EDO06243.1 - 4.5 7.5 13.6 11 6.2 13.6 1.8 1 1 0 1 1 1 0 Sodium ion transport-associated VWA PF00092.28 EDO06244.1 - 1.4e-15 58.0 2.5 7.3e-08 32.9 0.5 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 EDO06244.1 - 2.3e-06 28.2 0.2 0.12 13.0 0.1 3.8 3 0 0 3 3 3 2 von Willebrand factor type A domain TSP_1 PF00090.19 EDO06244.1 - 0.00022 21.3 19.2 0.0049 17.1 5.4 3.6 3 1 0 3 3 3 2 Thrombospondin type 1 domain DMAP1_like PF17024.5 EDO06244.1 - 0.046 13.9 2.0 0.16 12.1 0.1 2.3 2 0 0 2 2 2 0 Putative DMAP1-like DUF3083 PF11281.8 EDO06244.1 - 0.079 12.3 0.7 0.22 10.8 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3083) LAP1C PF05609.12 EDO06244.1 - 2.6 7.0 12.5 4.3 6.3 12.5 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) LSM PF01423.22 EDO06245.1 - 7e-12 44.9 0.0 9.4e-12 44.5 0.0 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EDO06245.1 - 0.037 13.7 0.0 0.063 12.9 0.0 1.3 1 0 0 1 1 1 0 Hfq protein VGCC_beta4Aa_N PF12052.8 EDO06245.1 - 0.046 13.8 0.0 0.074 13.2 0.0 1.4 1 0 0 1 1 1 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal LSM14 PF12701.7 EDO06245.1 - 0.072 13.2 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Scd6-like Sm domain NUDIX PF00293.28 EDO06246.1 - 4.5e-18 65.6 0.0 5.1e-18 65.4 0.0 1.0 1 0 0 1 1 1 1 NUDIX domain Endothelin PF00322.17 EDO06246.1 - 0.41 10.3 0.1 0.41 10.3 0.1 1.8 3 0 0 3 3 3 0 Endothelin family zf-CDGSH PF09360.10 EDO06247.1 - 2.7e-09 37.1 0.4 4.8e-09 36.3 0.4 1.4 1 0 0 1 1 1 1 Iron-binding zinc finger CDGSH type Tex_N PF09371.10 EDO06247.1 - 0.041 13.5 0.0 0.052 13.2 0.0 1.1 1 0 0 1 1 1 0 Tex-like protein N-terminal domain DHHC PF01529.20 EDO06248.1 - 2.8e-34 118.1 11.8 2.8e-34 118.1 11.8 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ccdc124 PF06244.12 EDO06249.1 - 9.7e-28 97.3 30.3 2.9e-25 89.3 30.3 2.8 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 DSS1_SEM1 PF05160.13 EDO06250.1 - 0.0048 16.9 13.0 0.0055 16.7 12.1 1.7 1 1 0 1 1 1 1 DSS1/SEM1 family DUF4863 PF16155.5 EDO06250.1 - 0.03 14.2 0.0 0.033 14.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4863) NOD2_WH PF17779.1 EDO06250.1 - 0.12 12.7 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 NOD2 winged helix domain Adaptin_N PF01602.20 EDO06251.1 - 2e-67 228.0 14.7 2.7e-67 227.6 14.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 EDO06251.1 - 2.9e-20 72.9 0.1 1e-19 71.2 0.1 1.9 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 EDO06251.1 - 1.1e-10 41.6 0.2 7.2e-09 35.8 0.0 3.1 3 1 0 3 3 3 1 Coatomer subunit gamma-1 C-terminal appendage platform Cnd1 PF12717.7 EDO06251.1 - 1.7e-10 41.2 4.9 1.7e-10 41.2 4.9 4.3 3 2 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDO06251.1 - 3.6e-08 33.7 0.4 0.051 14.0 0.0 4.9 3 1 1 4 4 4 1 HEAT repeats HEAT PF02985.22 EDO06251.1 - 0.0022 18.1 7.2 4.4 7.8 0.0 6.2 7 0 0 7 7 7 1 HEAT repeat SQHop_cyclase_N PF13249.6 EDO06251.1 - 0.017 14.3 0.0 0.038 13.1 0.0 1.6 1 0 0 1 1 1 0 Squalene-hopene cyclase N-terminal domain U3snoRNP10 PF12397.8 EDO06251.1 - 0.33 11.3 6.4 0.19 12.1 0.5 3.2 3 0 0 3 3 3 0 U3 small nucleolar RNA-associated protein 10 V-ATPase_H_C PF11698.8 EDO06251.1 - 0.35 11.0 10.3 6.1 7.0 0.3 4.4 4 0 0 4 4 4 0 V-ATPase subunit H Cript PF10235.9 EDO06252.1 - 4.1e-13 49.7 12.0 4.1e-13 49.7 12.0 1.7 1 1 1 2 2 2 1 Microtubule-associated protein CRIPT DUF1272 PF06906.11 EDO06252.1 - 0.036 14.1 2.7 0.036 14.1 2.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) DZR PF12773.7 EDO06252.1 - 0.19 11.7 14.4 0.22 11.6 6.1 2.4 1 1 1 2 2 2 0 Double zinc ribbon zinc_ribbon_15 PF17032.5 EDO06252.1 - 1 10.2 15.8 2.2 9.1 11.7 2.7 2 1 0 2 2 2 0 zinc-ribbon family Dynamin_M PF01031.20 EDO06253.1 - 1e-79 267.8 0.6 1.8e-79 266.9 0.0 1.7 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 EDO06253.1 - 2.2e-46 158.0 0.6 5.6e-46 156.7 0.0 2.0 3 0 0 3 3 3 1 Dynamin family GED PF02212.18 EDO06253.1 - 8.8e-19 67.5 1.0 2.7e-18 65.9 1.0 1.9 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EDO06253.1 - 0.00093 19.3 0.0 0.0032 17.5 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_15 PF13175.6 EDO06253.1 - 0.23 11.2 3.0 3.9 7.1 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain Peptidase_M22 PF00814.25 EDO06255.1 - 7.3e-75 252.2 0.0 8.6e-75 251.9 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family PCI PF01399.27 EDO06256.1 - 2.5e-11 44.0 3.1 1.8e-10 41.3 0.1 2.9 2 1 1 3 3 3 1 PCI domain SbcD_C PF12320.8 EDO06256.1 - 0.14 12.5 0.6 0.49 10.7 0.3 2.1 2 0 0 2 2 2 0 Type 5 capsule protein repressor C-terminal domain SpoU_methylase PF00588.19 EDO06258.1 - 4.1e-05 23.8 0.0 8.1e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 SpoU rRNA Methylase family LRR_4 PF12799.7 EDO06259.1 - 2.9e-29 100.6 24.3 2.9e-08 33.9 1.8 6.2 2 2 3 7 7 7 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDO06259.1 - 2.9e-21 75.0 23.3 2.3e-06 27.3 1.7 5.1 2 1 1 5 5 5 5 Leucine rich repeat LRR_9 PF14580.6 EDO06259.1 - 4.4e-14 52.4 12.5 3.4e-08 33.2 4.5 4.0 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 EDO06259.1 - 1.1e-06 28.3 15.5 4.7 8.1 0.2 7.9 7 1 0 7 7 7 3 Leucine Rich Repeat LRR_6 PF13516.6 EDO06259.1 - 3.6e-05 23.5 20.8 2.5 8.4 0.0 8.1 9 0 0 9 9 9 3 Leucine Rich repeat DUF2322 PF10084.9 EDO06259.1 - 0.13 12.3 1.0 7.7 6.6 0.2 2.9 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2322) WD40 PF00400.32 EDO06260.1 - 2e-48 161.3 32.3 2.6e-10 40.7 0.4 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO06260.1 - 1.9e-14 53.7 3.3 0.071 13.4 0.0 5.4 1 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EDO06260.1 - 2.7e-06 27.0 0.0 0.12 11.7 0.0 2.9 2 1 0 3 3 3 2 WD40-like domain Ge1_WD40 PF16529.5 EDO06260.1 - 4.1e-06 26.0 0.4 1.1 8.2 0.0 4.0 2 2 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EDO06260.1 - 0.00026 19.8 6.1 1.5 7.4 0.1 4.1 2 1 2 4 4 4 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EDO06260.1 - 0.012 14.4 2.9 0.87 8.3 0.0 3.4 3 1 0 3 3 3 0 Nup133 N terminal like PALB2_WD40 PF16756.5 EDO06260.1 - 0.026 13.5 0.3 0.026 13.5 0.3 2.2 3 0 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain PQQ_3 PF13570.6 EDO06260.1 - 0.034 14.6 0.7 0.24 11.9 0.0 2.8 4 0 0 4 4 4 0 PQQ-like domain Hira PF07569.11 EDO06260.1 - 0.78 9.4 4.5 0.73 9.5 0.1 2.7 2 2 1 3 3 3 0 TUP1-like enhancer of split RPAP1_C PF08620.10 EDO06261.1 - 2.5e-20 72.3 0.0 7.6e-20 70.8 0.0 1.8 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 EDO06261.1 - 0.00028 20.6 0.1 0.0014 18.3 0.1 2.2 2 0 0 2 2 2 1 RPAP1-like, N-terminal FAST_1 PF06743.15 EDO06262.1 - 0.064 13.2 0.2 0.45 10.5 0.0 2.5 2 1 1 3 3 3 0 FAST kinase-like protein, subdomain 1 MCM_OB PF17207.3 EDO06262.1 - 0.23 11.3 0.8 1.5 8.7 0.1 2.2 2 0 0 2 2 2 0 MCM OB domain WD40 PF00400.32 EDO06263.1 - 9.2e-57 187.7 33.4 1.6e-09 38.2 0.3 9.3 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO06263.1 - 6.1e-20 71.3 3.1 6.4e-06 26.4 0.0 5.8 2 2 4 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 EDO06263.1 - 1.1e-09 38.6 0.3 2.2e-09 37.7 0.3 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain Ge1_WD40 PF16529.5 EDO06263.1 - 1e-07 31.2 0.2 0.16 10.9 0.0 4.4 2 2 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EDO06263.1 - 0.001 17.8 3.2 3.6 6.1 0.2 4.1 3 1 1 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 EDO06263.1 - 0.19 11.0 0.0 0.7 9.2 0.0 2.0 3 0 0 3 3 3 0 WD40-like domain HTH_9 PF08221.11 EDO06264.1 - 1.7e-09 37.6 1.3 6e-09 35.9 0.1 2.7 4 0 0 4 4 4 1 RNA polymerase III subunit RPC82 helix-turn-helix domain HTH_34 PF13601.6 EDO06264.1 - 0.024 14.8 0.0 0.65 10.2 0.0 2.7 2 0 0 2 2 2 0 Winged helix DNA-binding domain RNA_pol_Rpc82 PF05645.13 EDO06264.1 - 0.038 13.8 0.3 4.2 7.0 0.1 2.3 1 1 0 2 2 2 0 RNA polymerase III subunit RPC82 DctQ PF04290.12 EDO06265.1 - 0.0072 16.3 1.6 0.0091 15.9 1.6 1.1 1 0 0 1 1 1 1 Tripartite ATP-independent periplasmic transporters, DctQ component Yip1 PF04893.17 EDO06265.1 - 0.017 14.8 2.2 0.024 14.4 2.2 1.1 1 0 0 1 1 1 0 Yip1 domain DUF4059 PF13268.6 EDO06265.1 - 0.053 13.9 1.6 0.25 11.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4059) TMEM190 PF15431.6 EDO06265.1 - 0.14 12.4 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 Transmembrane protein 190 SIT PF15330.6 EDO06265.1 - 0.24 11.9 0.0 0.24 11.9 0.0 1.5 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT LapA_dom PF06305.11 EDO06265.1 - 0.35 10.7 3.5 0.59 10.0 0.0 2.2 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain DUF2721 PF11026.8 EDO06265.1 - 0.39 10.6 5.7 3.1 7.7 6.1 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2721) ATP-synt_I PF03899.15 EDO06265.1 - 0.43 11.0 5.6 1.1 9.7 5.6 1.6 1 1 0 1 1 1 0 ATP synthase I chain Ribosomal_L11_N PF03946.14 EDO06266.1 - 2.5e-22 78.5 0.2 3.7e-22 77.9 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 EDO06266.1 - 4.1e-15 56.1 0.1 6.6e-15 55.4 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Cas_Cas02710 PF09670.10 EDO06267.1 - 0.081 11.7 0.3 0.91 8.3 0.3 2.0 1 1 0 1 1 1 0 CRISPR-associated protein (Cas_Cas02710) GTP_EFTU PF00009.27 EDO06268.1 - 2.3e-21 76.2 1.5 4.5e-19 68.7 1.4 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EDO06268.1 - 4e-18 65.5 3.0 1.5e-17 63.6 0.8 2.3 2 0 0 2 2 2 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 EDO06268.1 - 7.4e-11 42.1 0.1 2e-09 37.5 0.1 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase Ras PF00071.22 EDO06268.1 - 2e-06 27.5 0.1 4.3e-06 26.4 0.1 1.5 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EDO06268.1 - 8.1e-06 25.4 0.1 2.4e-05 23.8 0.0 1.9 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EDO06268.1 - 0.00019 21.7 0.0 0.00049 20.3 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EDO06268.1 - 0.00067 19.6 1.2 0.24 11.3 0.1 3.1 2 1 2 4 4 4 2 RsgA GTPase FeoB_N PF02421.18 EDO06268.1 - 0.00072 19.1 0.3 0.0029 17.2 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B PduV-EutP PF10662.9 EDO06268.1 - 0.0031 17.3 0.2 0.0079 15.9 0.2 1.6 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 EDO06268.1 - 0.0087 15.5 0.0 0.02 14.3 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family AIG1 PF04548.16 EDO06268.1 - 0.06 12.7 0.1 0.14 11.5 0.1 1.6 1 0 0 1 1 1 0 AIG1 family PseudoU_synth_1 PF01416.20 EDO06270.1 - 0.00052 20.5 0.0 0.001 19.5 0.0 1.7 1 1 0 1 1 1 1 tRNA pseudouridine synthase Ribosomal_S11 PF00411.19 EDO06271.1 - 2e-46 156.9 0.6 3e-46 156.3 0.6 1.3 1 0 0 1 1 1 1 Ribosomal protein S11 Pilus_CpaD PF09476.10 EDO06271.1 - 0.047 13.4 0.1 0.073 12.8 0.1 1.3 1 0 0 1 1 1 0 Pilus biogenesis CpaD protein (pilus_cpaD) DUF2252 PF10009.9 EDO06271.1 - 0.076 12.1 0.0 0.094 11.8 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) CBM60 PF16841.5 EDO06272.1 - 0.051 14.0 0.1 2.6 8.5 0.1 3.4 3 0 0 3 3 3 0 Ca-dependent carbohydrate-binding module xylan-binding Y_Y_Y PF07495.13 EDO06272.1 - 0.13 12.3 0.1 0.32 11.0 0.1 1.7 1 0 0 1 1 1 0 Y_Y_Y domain NIF PF03031.18 EDO06273.1 - 1.4e-38 132.1 0.2 1.7e-38 131.8 0.2 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BolA PF01722.18 EDO06274.1 - 1.3e-16 60.6 0.0 3.5e-16 59.2 0.0 1.6 1 1 0 1 1 1 1 BolA-like protein zf-B_box PF00643.24 EDO06276.1 - 6.1e-16 58.3 15.3 8.7e-08 32.2 4.0 2.5 2 0 0 2 2 2 2 B-box zinc finger PARP PF00644.20 EDO06276.1 - 0.0036 16.9 0.0 0.013 15.1 0.0 2.0 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain BORCS8 PF10167.9 EDO06276.1 - 0.018 15.0 2.1 0.04 13.8 2.1 1.5 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 8 NAPRTase_N PF17767.1 EDO06276.1 - 0.07 13.5 0.0 0.21 12.0 0.0 1.8 1 0 0 1 1 1 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain ApoLp-III PF07464.11 EDO06276.1 - 0.12 12.4 2.5 0.24 11.5 2.5 1.4 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) DUF2318 PF10080.9 EDO06276.1 - 5.8 7.1 8.6 0.21 11.7 1.1 2.4 3 0 0 3 3 3 0 Predicted membrane protein (DUF2318) zf-NOSIP PF15906.5 EDO06277.1 - 8.3e-12 45.1 0.3 1.5e-11 44.3 0.3 1.4 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-C3HC4_4 PF15227.6 EDO06277.1 - 0.00073 19.6 3.1 0.0017 18.5 3.1 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Egg_lysin PF01303.17 EDO06277.1 - 0.062 13.5 0.2 0.13 12.5 0.2 1.5 1 0 0 1 1 1 0 Egg lysin (Sperm-lysin) zf-C3HC4_2 PF13923.6 EDO06277.1 - 0.068 13.0 3.5 0.18 11.7 3.5 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDO06277.1 - 0.07 13.0 3.5 0.17 11.8 3.5 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDO06277.1 - 0.2 11.7 4.3 0.11 12.6 1.7 1.9 2 0 0 2 2 2 0 RING-type zinc-finger zf-RING_5 PF14634.6 EDO06277.1 - 0.29 11.1 6.2 0.64 10.0 6.2 1.6 1 0 0 1 1 1 0 zinc-RING finger domain AP2 PF00847.20 EDO06278.1 - 1.8e-10 40.9 6.0 2.8e-07 30.7 0.8 2.3 2 0 0 2 2 2 2 AP2 domain p25-alpha PF05517.12 EDO06279.1 - 6.2e-10 39.5 0.1 9e-10 38.9 0.1 1.3 1 0 0 1 1 1 1 p25-alpha DCX PF03607.17 EDO06279.1 - 3e-08 33.7 0.0 6.4e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Doublecortin eIF2A PF08662.11 EDO06280.1 - 3.7e-27 95.5 0.3 6e-20 71.9 0.3 4.5 2 2 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 EDO06280.1 - 9.4e-05 22.2 0.1 0.00046 20.0 0.1 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.32 EDO06280.1 - 0.00031 21.5 0.2 0.78 10.7 0.1 4.5 5 0 0 5 5 5 1 WD domain, G-beta repeat UbiA PF01040.18 EDO06281.1 - 2.8e-44 151.3 7.8 3.7e-44 150.9 7.8 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family Ribosomal_S24e PF01282.19 EDO06282.1 - 2e-29 101.3 0.0 3.9e-29 100.4 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S24e DEAD PF00270.29 EDO06283.1 - 1.4e-45 155.2 0.1 1.5e-44 151.9 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO06283.1 - 2.8e-30 104.9 0.2 9.7e-30 103.2 0.2 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain mit_SMPDase PF14724.6 EDO06283.1 - 0.16 9.9 0.2 0.24 9.4 0.2 1.1 1 0 0 1 1 1 0 Mitochondrial-associated sphingomyelin phosphodiesterase RRF PF01765.19 EDO06283.1 - 0.26 11.2 9.4 0.83 9.6 9.4 1.8 1 0 0 1 1 1 0 Ribosome recycling factor WD40 PF00400.32 EDO06284.1 - 5.4e-21 74.5 12.5 3.9e-07 30.7 0.8 6.6 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO06284.1 - 1.8e-05 25.0 0.4 0.045 14.1 0.1 3.9 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDO06284.1 - 0.024 13.6 0.1 0.22 10.5 0.1 2.1 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PUF PF00806.19 EDO06285.1 - 7e-53 173.4 8.4 3.5e-07 29.5 0.1 8.6 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.11 EDO06285.1 - 0.012 16.0 2.7 4.4 7.6 0.1 4.4 1 1 3 5 5 5 0 CPL (NUC119) domain CAF1 PF04857.20 EDO06286.1 - 6.6e-23 81.4 0.0 2.9e-16 59.6 0.0 2.0 2 0 0 2 2 2 2 CAF1 family ribonuclease RRN3 PF05327.11 EDO06288.1 - 2.8e-40 138.4 1.4 1.1e-39 136.5 0.7 1.9 2 0 0 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 DUF3223 PF11523.8 EDO06288.1 - 3.3e-06 27.8 0.0 8.1e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3223) AMP-binding_C_2 PF14535.6 EDO06288.1 - 0.18 12.2 0.3 1.3 9.4 0.1 2.6 2 1 0 2 2 2 0 AMP-binding enzyme C-terminal domain AMMECR1 PF01871.17 EDO06289.1 - 2.9e-42 144.1 0.0 3.3e-42 143.9 0.0 1.0 1 0 0 1 1 1 1 AMMECR1 EF_TS PF00889.19 EDO06291.1 - 5.4e-28 98.0 0.6 1e-12 48.1 0.0 2.2 2 0 0 2 2 2 2 Elongation factor TS HOIP-UBA PF16678.5 EDO06291.1 - 0.0012 18.9 0.6 0.0047 16.9 0.2 2.1 2 0 0 2 2 2 1 HOIP UBA domain pair Sec1 PF00995.23 EDO06292.1 - 2.2e-92 311.1 0.1 2.5e-92 311.0 0.1 1.0 1 0 0 1 1 1 1 Sec1 family RabGAP-TBC PF00566.18 EDO06293.1 - 3.1e-27 95.6 9.9 1.4e-24 87.0 9.8 2.5 1 1 0 1 1 1 1 Rab-GTPase-TBC domain ANAPC4_WD40 PF12894.7 EDO06294.1 - 0.00039 20.6 0.5 0.0029 17.9 0.1 2.5 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain NUC153 PF08159.12 EDO06294.1 - 0.0031 17.3 1.7 0.0064 16.3 1.7 1.5 1 0 0 1 1 1 1 NUC153 domain RAB3GAP2_N PF14655.6 EDO06294.1 - 0.13 11.5 0.0 0.24 10.6 0.0 1.4 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus WD40 PF00400.32 EDO06294.1 - 0.21 12.5 0.8 2.9e+02 2.6 0.0 4.3 3 1 1 4 4 4 0 WD domain, G-beta repeat zf-primase PF09329.11 EDO06296.1 - 2.6e-08 33.6 1.3 2.6e-08 33.6 1.3 2.8 3 0 0 3 3 3 1 Primase zinc finger Mcm10 PF09332.11 EDO06296.1 - 0.0026 17.2 23.0 0.0089 15.5 22.8 2.0 1 1 1 2 2 2 1 Mcm10 replication factor TDA11 PF17084.5 EDO06296.1 - 0.0043 16.0 2.1 0.0073 15.3 2.1 1.3 1 0 0 1 1 1 1 Topoisomerase I damage affected protein 11 TTC5_OB PF16669.5 EDO06296.1 - 0.041 13.6 1.0 0.074 12.7 0.2 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat protein 5 OB fold domain PDZ_1 PF12812.7 EDO06296.1 - 0.23 11.5 1.2 1.6 8.8 0.0 2.6 2 1 1 3 3 3 0 PDZ-like domain Acid_PPase PF12689.7 EDO06297.1 - 0.00067 19.6 0.1 0.0042 16.9 0.0 2.1 3 0 0 3 3 3 1 Acid Phosphatase HAD_2 PF13419.6 EDO06297.1 - 0.0015 18.6 0.3 0.72 9.9 0.0 2.8 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase PCRF PF03462.18 EDO06298.1 - 1.2e-25 90.5 0.4 6.4e-25 88.2 0.0 2.1 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 EDO06298.1 - 1.1e-24 86.6 2.2 1.8e-24 85.9 2.2 1.3 1 0 0 1 1 1 1 RF-1 domain MIR PF02815.19 EDO06298.1 - 0.012 15.5 0.9 0.019 14.8 0.9 1.3 1 0 0 1 1 1 0 MIR domain MIF4G PF02854.19 EDO06299.1 - 2.3e-29 102.6 2.4 3.5e-29 102.0 2.4 1.3 1 0 0 1 1 1 1 MIF4G domain PAM2 PF07145.15 EDO06299.1 - 1.5e-06 27.4 0.3 0.072 12.8 0.6 2.6 2 0 0 2 2 2 2 Ataxin-2 C-terminal region MA3 PF02847.17 EDO06299.1 - 0.072 13.1 0.8 0.18 11.8 0.1 2.1 2 0 0 2 2 2 0 MA3 domain Bystin PF05291.11 EDO06300.1 - 5.6e-93 311.4 0.8 9.1e-93 310.7 0.8 1.3 1 0 0 1 1 1 1 Bystin Ribosomal_L36e PF01158.18 EDO06301.1 - 6.1e-37 125.8 3.2 7.3e-37 125.5 3.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L36e DUF2423 PF10338.9 EDO06302.1 - 0.00025 21.2 1.0 0.00025 21.2 1.0 2.3 3 1 0 3 3 3 1 Protein of unknown function (DUF2423) JAB PF01398.21 EDO06303.1 - 2.2e-29 101.8 0.0 4.6e-29 100.8 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EDO06303.1 - 1.6e-25 89.7 0.3 2.6e-25 89.0 0.3 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function CUE PF02845.16 EDO06303.1 - 0.035 13.8 0.1 0.07 12.8 0.1 1.5 1 0 0 1 1 1 0 CUE domain DnaJ PF00226.31 EDO06304.1 - 1.6e-18 66.6 0.4 1.6e-18 66.6 0.4 2.8 2 1 0 2 2 2 1 DnaJ domain LMBR1 PF04791.16 EDO06304.1 - 0.019 13.9 2.5 0.023 13.6 2.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Neur_chan_memb PF02932.16 EDO06304.1 - 0.089 12.8 0.4 0.1 12.6 0.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region HSCB_C PF07743.13 EDO06304.1 - 0.16 12.5 9.5 7.9 7.1 0.2 3.4 2 1 0 2 2 2 0 HSCB C-terminal oligomerisation domain DUF2115 PF09888.9 EDO06304.1 - 0.16 12.5 5.2 0.077 13.5 0.8 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) PSD5 PF07637.11 EDO06304.1 - 0.4 11.1 3.7 5.8 7.4 0.0 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF1595) DUF4854 PF16146.5 EDO06304.1 - 1.1 9.6 11.8 2.7 8.4 1.2 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4854) Uso1_p115_C PF04871.13 EDO06304.1 - 1.8 8.9 14.1 3.9 7.9 7.1 2.6 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Med26 PF08711.11 EDO06306.1 - 0.00014 21.8 0.0 0.00041 20.3 0.0 1.8 1 0 0 1 1 1 1 TFIIS helical bundle-like domain MS_channel PF00924.18 EDO06308.1 - 1.4e-11 44.3 3.1 2.8e-11 43.3 3.1 1.5 1 0 0 1 1 1 1 Mechanosensitive ion channel Tudor_RapA PF18337.1 EDO06308.1 - 0.17 12.0 0.2 0.83 9.9 0.0 2.2 2 0 0 2 2 2 0 RapA N-terminal Tudor like domain Rad51 PF08423.11 EDO06309.1 - 5.9e-103 343.6 0.0 7.8e-103 343.2 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EDO06309.1 - 2.3e-09 37.1 0.1 4e-09 36.3 0.1 1.4 1 1 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 EDO06309.1 - 4.7e-06 26.1 0.6 1.5e-05 24.5 0.6 2.0 1 1 0 1 1 1 1 KaiC AAA_25 PF13481.6 EDO06309.1 - 2e-05 24.3 0.0 4.8e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 EDO06309.1 - 0.0018 18.8 0.6 0.0056 17.3 0.6 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix domain RNA_pol_A_CTD PF03118.15 EDO06309.1 - 0.0067 16.2 0.1 0.013 15.2 0.1 1.5 1 0 0 1 1 1 1 Bacterial RNA polymerase, alpha chain C terminal domain AAA_24 PF13479.6 EDO06309.1 - 0.035 13.8 0.0 0.06 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EDO06309.1 - 0.14 12.4 0.0 0.25 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain Pescadillo_N PF06732.11 EDO06310.1 - 8.2e-86 287.9 1.6 1.3e-85 287.3 1.6 1.2 1 0 0 1 1 1 1 Pescadillo N-terminus BRCT_2 PF16589.5 EDO06310.1 - 1e-09 38.7 0.0 2.5e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EDO06310.1 - 0.034 14.4 0.0 0.086 13.1 0.0 1.6 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain MS_channel PF00924.18 EDO06311.1 - 4.3e-17 62.4 0.9 7.6e-17 61.5 0.9 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_8 PF13833.6 EDO06311.1 - 0.083 12.8 0.4 0.25 11.2 0.4 1.8 1 0 0 1 1 1 0 EF-hand domain pair Bromodomain PF00439.25 EDO06312.1 - 6.8e-16 58.1 0.0 1.9e-15 56.7 0.0 1.8 1 0 0 1 1 1 1 Bromodomain GPAT_N PF14829.6 EDO06313.1 - 0.053 13.5 0.0 0.19 11.7 0.0 1.9 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase N-terminal DUF3586 PF12131.8 EDO06313.1 - 0.26 11.5 1.2 35 4.7 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3586) Mago_nashi PF02792.14 EDO06314.1 - 1.3e-67 226.3 0.1 1.8e-67 225.9 0.1 1.1 1 0 0 1 1 1 1 Mago nashi protein TcpE PF12648.7 EDO06314.1 - 0.13 12.8 4.3 2.1 8.9 3.4 2.3 2 0 0 2 2 2 0 TcpE family PQQ PF01011.21 EDO06315.1 - 0.012 15.5 0.7 0.31 11.1 0.0 2.9 3 0 0 3 3 3 0 PQQ enzyme repeat Hira PF07569.11 EDO06315.1 - 0.3 10.8 0.8 18 5.0 0.0 2.7 3 0 0 3 3 3 0 TUP1-like enhancer of split START PF01852.19 EDO06316.1 - 2e-08 33.9 0.2 2.5e-08 33.6 0.2 1.1 1 0 0 1 1 1 1 START domain AMP-binding PF00501.28 EDO06318.1 - 5.6e-88 295.4 0.0 6.7e-88 295.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 EDO06318.1 - 1.2e-21 76.4 0.3 5.3e-21 74.3 0.2 2.1 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 EDO06318.1 - 1.3e-17 64.5 0.1 3.9e-17 63.0 0.0 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain HEAT_EZ PF13513.6 EDO06319.1 - 1.3e-20 73.5 1.7 4.4e-10 39.8 0.0 7.9 7 1 1 8 8 8 2 HEAT-like repeat HEAT PF02985.22 EDO06319.1 - 4.4e-13 48.3 10.0 0.0013 18.8 0.0 8.8 8 0 0 8 8 8 4 HEAT repeat HEAT_2 PF13646.6 EDO06319.1 - 7.6e-13 48.7 0.1 1.1e-05 25.8 0.1 6.7 4 3 2 6 6 6 3 HEAT repeats IBN_N PF03810.19 EDO06319.1 - 9e-08 31.9 0.1 2.5e-05 24.1 0.0 3.8 4 0 0 4 4 4 1 Importin-beta N-terminal domain Arm PF00514.23 EDO06319.1 - 0.0055 16.7 8.7 2.4 8.3 0.0 5.6 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat DUF3437 PF11919.8 EDO06319.1 - 0.0055 16.6 1.0 0.26 11.2 0.1 3.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3437) CLASP_N PF12348.8 EDO06319.1 - 0.066 12.8 0.2 26 4.3 0.0 3.9 5 1 0 5 5 5 0 CLASP N terminal DUF3730 PF12530.8 EDO06319.1 - 0.097 12.2 1.4 2.3 7.8 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3730) Anticodon_1 PF08264.13 EDO06319.1 - 0.23 11.4 2.0 0.44 10.5 0.1 2.5 3 0 0 3 3 3 0 Anticodon-binding domain of tRNA Thioredoxin PF00085.20 EDO06320.1 - 6.8e-26 90.2 0.1 7.7e-26 90.1 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EDO06320.1 - 2.6e-06 27.7 0.2 2e-05 24.8 0.1 1.9 1 1 1 2 2 2 1 Thioredoxin-like OST3_OST6 PF04756.13 EDO06320.1 - 0.00019 20.9 0.2 0.00021 20.7 0.2 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_3 PF13192.6 EDO06320.1 - 0.00042 20.3 0.0 0.017 15.2 0.0 2.1 1 1 1 2 2 2 1 Thioredoxin domain Redoxin PF08534.10 EDO06320.1 - 0.0009 19.0 0.1 0.0011 18.7 0.1 1.3 1 1 0 1 1 1 1 Redoxin Thioredoxin_2 PF13098.6 EDO06320.1 - 0.0087 16.5 0.3 0.023 15.1 0.3 1.7 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 EDO06320.1 - 0.014 15.3 0.2 0.023 14.6 0.2 1.4 1 1 0 1 1 1 0 AhpC/TSA family Thioredoxin_9 PF14595.6 EDO06320.1 - 0.017 14.9 0.0 0.017 14.9 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin TraF PF13728.6 EDO06320.1 - 0.028 14.2 0.0 0.032 14.0 0.0 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein Sep15_SelM PF08806.11 EDO06320.1 - 0.045 13.9 0.0 0.064 13.4 0.0 1.4 1 0 0 1 1 1 0 Sep15/SelM redox domain Phosducin PF02114.16 EDO06320.1 - 0.086 11.8 0.0 0.086 11.8 0.0 1.1 1 0 0 1 1 1 0 Phosducin Ribosomal_L28 PF00830.19 EDO06321.1 - 0.0042 17.2 0.4 0.013 15.7 0.1 1.8 2 0 0 2 2 2 1 Ribosomal L28 family STAG PF08514.11 EDO06322.1 - 4.1e-05 23.5 0.0 0.00012 22.0 0.0 1.8 1 0 0 1 1 1 1 STAG domain Adaptin_N PF01602.20 EDO06323.1 - 9.8e-76 255.4 0.1 3e-75 253.8 0.1 1.6 2 0 0 2 2 2 1 Adaptin N terminal region Cnd1 PF12717.7 EDO06323.1 - 0.0052 16.8 0.4 1.5 8.8 0.0 2.6 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDO06323.1 - 0.097 13.1 0.1 40 4.7 0.0 3.4 3 0 0 3 3 3 0 HEAT repeats C2 PF00168.30 EDO06324.1 - 3.6e-11 43.3 0.0 0.00095 19.4 0.0 4.0 4 0 0 4 4 4 2 C2 domain RPGR1_C PF18111.1 EDO06324.1 - 0.16 11.9 0.1 11 5.9 0.0 2.9 3 0 0 3 3 3 0 Retinitis pigmentosa G-protein regulator interacting C-terminal LCCL PF03815.19 EDO06325.1 - 6e-13 48.7 0.1 6e-13 48.7 0.1 2.5 2 0 0 2 2 2 1 LCCL domain F5_F8_type_C PF00754.25 EDO06325.1 - 2.4e-12 47.1 6.9 4.2e-09 36.6 0.3 2.9 3 0 0 3 3 3 2 F5/8 type C domain Fibrinogen_C PF00147.18 EDO06325.1 - 0.025 14.4 0.0 0.052 13.3 0.0 1.5 1 0 0 1 1 1 0 Fibrinogen beta and gamma chains, C-terminal globular domain EMP24_GP25L PF01105.24 EDO06325.1 - 4.2 7.3 6.8 5.1 7.0 1.4 2.8 3 0 0 3 3 3 0 emp24/gp25L/p24 family/GOLD Vac_Fusion PF02346.16 EDO06325.1 - 8 6.2 5.8 5.7 6.7 0.2 3.2 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 RAP PF08373.10 EDO06327.1 - 0.0016 18.5 0.1 0.0046 17.0 0.1 1.8 1 0 0 1 1 1 1 RAP domain Arm PF00514.23 EDO06329.1 - 0.00015 21.7 0.0 0.74 10.0 0.0 3.3 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 EDO06329.1 - 0.064 12.8 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 Atypical Arm repeat HlyIII PF03006.20 EDO06330.1 - 8.2e-16 58.4 12.8 1e-15 58.1 12.8 1.1 1 0 0 1 1 1 1 Haemolysin-III related OST3_OST6 PF04756.13 EDO06331.1 - 0.93 8.8 6.1 0.42 9.9 3.1 1.9 1 1 1 2 2 2 0 OST3 / OST6 family, transporter family Methyltransf_31 PF13847.6 EDO06333.1 - 0.0013 18.5 0.0 0.0014 18.4 0.0 1.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDO06333.1 - 0.0096 16.6 0.0 0.0096 16.6 0.0 1.0 1 0 0 1 1 1 1 Methyltransferase domain FAST_1 PF06743.15 EDO06334.1 - 0.00034 20.5 1.1 0.73 9.8 0.0 4.0 3 2 1 4 4 4 3 FAST kinase-like protein, subdomain 1 NanE PF04131.14 EDO06334.1 - 0.12 11.5 0.4 0.3 10.3 0.1 1.8 2 0 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase RNA_pol_Rpb4 PF03874.16 EDO06334.1 - 0.54 10.6 3.0 1.1 9.6 0.1 2.8 3 1 0 3 3 3 0 RNA polymerase Rpb4 NAP PF00956.18 EDO06335.1 - 7.9e-20 71.2 0.0 1.2e-19 70.5 0.0 1.4 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) Baculo_PEP_C PF04513.12 EDO06335.1 - 0.009 16.1 0.3 0.013 15.5 0.3 1.2 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus Mis14 PF08641.12 EDO06335.1 - 0.0098 16.2 0.2 0.021 15.1 0.2 1.6 1 0 0 1 1 1 1 Kinetochore protein Mis14 like PMEI PF04043.15 EDO06335.1 - 0.036 14.4 0.2 0.099 13.0 0.2 1.7 1 0 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor CLZ PF16526.5 EDO06335.1 - 0.065 13.6 1.5 0.13 12.6 0.9 1.8 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels WD40 PF00400.32 EDO06336.1 - 1.4e-20 73.2 21.9 1.3e-05 25.8 0.8 6.8 6 1 0 6 6 6 5 WD domain, G-beta repeat WD40_like PF17005.5 EDO06336.1 - 0.0017 17.7 0.1 0.0079 15.6 0.0 2.1 2 1 0 3 3 3 1 WD40-like domain ANAPC4_WD40 PF12894.7 EDO06336.1 - 0.028 14.7 0.0 8.6 6.7 0.0 3.7 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain DUF5046 PF16465.5 EDO06336.1 - 0.039 13.4 0.1 0.063 12.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5046) Antig_Caf1 PF09255.10 EDO06336.1 - 0.1 12.7 0.1 0.24 11.5 0.1 1.7 1 1 0 1 1 1 0 Caf1 Capsule antigen SF-assemblin PF06705.11 EDO06337.1 - 6.3e-36 124.0 26.0 8e-36 123.6 26.0 1.0 1 0 0 1 1 1 1 SF-assemblin/beta giardin hnRNP_Q_AcD PF18360.1 EDO06337.1 - 0.00033 20.5 2.5 0.013 15.4 0.3 2.6 1 1 1 2 2 2 1 Heterogeneous nuclear ribonucleoprotein Q acidic domain ALMT PF11744.8 EDO06337.1 - 0.0013 17.7 11.7 0.0016 17.4 11.7 1.2 1 0 0 1 1 1 1 Aluminium activated malate transporter Baculo_PEP_C PF04513.12 EDO06337.1 - 0.0025 17.9 12.5 0.089 12.8 4.1 2.5 2 1 0 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus BshC PF10079.9 EDO06337.1 - 0.025 13.3 22.0 0.19 10.4 0.8 2.9 1 1 2 3 3 3 0 Bacillithiol biosynthesis BshC DUF1664 PF07889.12 EDO06337.1 - 0.27 11.3 14.3 3.1 7.9 1.0 3.0 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) NPV_P10 PF05531.12 EDO06337.1 - 0.53 10.8 8.4 0.86 10.1 0.7 3.6 3 2 1 4 4 3 0 Nucleopolyhedrovirus P10 protein DUF4407 PF14362.6 EDO06337.1 - 0.65 9.3 14.2 2.1 7.6 14.2 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Apolipoprotein PF01442.18 EDO06337.1 - 1.1 9.1 19.8 0.11 12.3 3.3 2.2 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain DUF885 PF05960.11 EDO06337.1 - 1.5 8.3 8.4 5.3 6.6 8.4 1.7 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF885) KxDL PF10241.9 EDO06337.1 - 2.8 8.3 11.7 0.32 11.3 0.7 3.3 1 1 2 3 3 3 0 Uncharacterized conserved protein Borrelia_REV PF03978.13 EDO06337.1 - 3.4 7.6 18.4 0.74 9.8 0.7 3.5 2 2 1 3 3 3 0 Borrelia burgdorferi REV protein DUF948 PF06103.11 EDO06337.1 - 7.1 7.0 7.6 21 5.5 1.0 2.9 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) FlxA PF14282.6 EDO06337.1 - 9.9 6.2 21.4 0.81 9.7 4.0 3.3 2 1 1 3 3 3 0 FlxA-like protein RWD PF05773.22 EDO06338.1 - 2.2e-13 50.5 0.1 4e-13 49.7 0.1 1.4 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.5 EDO06338.1 - 0.0012 19.3 1.2 0.0032 17.9 0.3 2.1 2 0 0 2 2 2 1 DRG Family Regulatory Proteins, Tma46 DUF4559 PF15112.6 EDO06338.1 - 0.026 14.2 0.3 0.037 13.7 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) XPG_I PF00867.18 EDO06341.1 - 2.6e-22 79.0 0.3 9.5e-22 77.2 0.0 2.1 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 EDO06341.1 - 2e-16 60.3 0.0 5.2e-16 59.0 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 EDO06341.1 - 0.00023 20.7 0.0 0.00046 19.7 0.0 1.4 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.20 EDO06341.1 - 0.013 16.1 0.0 0.049 14.2 0.0 1.9 2 0 0 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold PAC2 PF09754.9 EDO06341.1 - 0.036 14.1 0.0 0.11 12.5 0.0 1.7 2 0 0 2 2 2 0 PAC2 family zf-CCCH PF00642.24 EDO06342.1 - 6.1e-09 35.6 2.2 6.1e-09 35.6 2.2 2.0 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDO06342.1 - 1.7e-05 24.7 6.3 3.7e-05 23.6 6.3 1.6 1 0 0 1 1 1 1 Zinc finger domain NUFIP1 PF10453.9 EDO06342.1 - 0.00024 20.9 0.8 0.00045 20.0 0.8 1.3 1 0 0 1 1 1 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-CCCH_4 PF18044.1 EDO06342.1 - 0.00049 19.8 2.3 0.00049 19.8 2.3 2.0 2 0 0 2 2 2 1 CCCH-type zinc finger DUF5455 PF17537.2 EDO06343.1 - 0.089 13.2 0.1 1.2 9.6 0.1 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5455) WD40 PF00400.32 EDO06344.1 - 3.2e-34 116.4 7.9 1.3e-06 29.0 0.0 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO06344.1 - 8e-16 58.1 0.3 0.036 14.4 0.1 5.9 2 2 4 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EDO06344.1 - 4.7e-09 36.0 0.3 0.0016 17.9 0.1 3.0 3 0 0 3 3 3 2 WD40-like domain PQQ PF01011.21 EDO06344.1 - 1e-05 25.2 0.0 0.35 10.9 0.0 3.2 3 0 0 3 3 3 2 PQQ enzyme repeat PQQ_3 PF13570.6 EDO06344.1 - 0.0094 16.4 5.4 9.5 6.9 0.0 5.0 6 0 0 6 6 6 1 PQQ-like domain Ge1_WD40 PF16529.5 EDO06344.1 - 0.021 13.8 0.0 0.41 9.6 0.0 2.6 2 1 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 EDO06344.1 - 0.032 12.6 0.0 2.4 6.4 0.0 2.2 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz AAA PF00004.29 EDO06345.1 - 8.8e-42 142.7 0.0 1.6e-41 141.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO06345.1 - 4.5e-10 39.2 0.2 9.7e-10 38.1 0.2 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EDO06345.1 - 1.2e-07 31.6 0.1 2.1e-07 30.8 0.1 1.4 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 EDO06345.1 - 1.2e-06 28.7 0.0 2.5e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EDO06345.1 - 7.9e-06 25.9 0.1 0.00019 21.4 0.1 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EDO06345.1 - 1.6e-05 24.7 0.0 3.4e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDO06345.1 - 1.7e-05 25.2 0.1 0.0042 17.5 0.1 2.5 1 1 1 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 EDO06345.1 - 0.00079 18.7 0.0 0.0013 17.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EDO06345.1 - 0.001 19.4 0.1 0.034 14.4 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_7 PF12775.7 EDO06345.1 - 0.001 18.6 0.0 0.0025 17.4 0.0 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region RNA_helicase PF00910.22 EDO06345.1 - 0.0012 19.2 0.0 0.0024 18.2 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.6 EDO06345.1 - 0.0021 18.6 0.0 0.0046 17.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 EDO06345.1 - 0.0041 17.0 0.0 0.0084 16.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 EDO06345.1 - 0.0044 16.3 0.0 0.0078 15.5 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 EDO06345.1 - 0.0045 16.4 0.1 0.0089 15.4 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EDO06345.1 - 0.0087 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Med4 PF10018.9 EDO06345.1 - 0.011 15.4 0.2 0.04 13.6 0.1 1.8 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Parvo_NS1 PF01057.17 EDO06345.1 - 0.015 14.4 0.0 0.024 13.7 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_24 PF13479.6 EDO06345.1 - 0.023 14.4 0.5 0.081 12.6 0.1 1.9 2 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EDO06345.1 - 0.023 14.4 0.0 0.079 12.7 0.0 1.9 2 1 0 2 2 1 0 Sigma-54 interaction domain AAA_25 PF13481.6 EDO06345.1 - 0.036 13.6 0.3 0.12 12.0 0.1 1.9 2 0 0 2 2 2 0 AAA domain DUF4200 PF13863.6 EDO06345.1 - 0.047 14.1 0.2 0.097 13.1 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) AAA_14 PF13173.6 EDO06345.1 - 0.047 13.7 0.0 0.093 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EDO06345.1 - 0.056 12.8 0.0 0.13 11.6 0.0 1.6 1 0 0 1 1 1 0 KaiC AAA_28 PF13521.6 EDO06345.1 - 0.058 13.6 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EDO06345.1 - 0.064 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 EDO06345.1 - 0.074 13.2 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EDO06345.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Prot_ATP_OB_N PF17758.1 EDO06345.1 - 0.11 12.2 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain AAA_11 PF13086.6 EDO06345.1 - 0.13 12.0 0.2 0.48 10.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EDO06345.1 - 0.17 11.8 0.1 1.3 8.9 0.0 2.1 2 0 0 2 2 2 0 NACHT domain HEAT_EZ PF13513.6 EDO06347.1 - 1.8e-09 37.9 2.7 7 7.3 0.0 9.2 8 1 1 9 9 9 2 HEAT-like repeat CLASP_N PF12348.8 EDO06347.1 - 1.3e-07 31.4 0.6 0.0082 15.7 0.0 5.3 5 0 0 5 5 5 1 CLASP N terminal HEAT PF02985.22 EDO06347.1 - 1.9e-07 30.7 12.9 0.0043 17.2 0.0 7.6 8 0 0 8 8 8 3 HEAT repeat Vac14_Fab1_bd PF12755.7 EDO06347.1 - 6.7e-07 29.8 3.1 0.25 11.9 0.0 7.1 7 0 0 7 7 7 1 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.6 EDO06347.1 - 4.9e-06 26.8 0.8 0.14 12.6 0.0 6.5 7 1 0 8 8 8 1 HEAT repeats IFRD PF05004.13 EDO06347.1 - 0.00065 18.9 2.2 0.9 8.6 0.0 4.1 3 0 0 3 3 3 2 Interferon-related developmental regulator (IFRD) Arm PF00514.23 EDO06347.1 - 0.11 12.6 2.0 6.4 7.0 0.0 5.1 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat UME PF08064.13 EDO06347.1 - 0.37 10.7 5.7 1.1e+02 2.8 0.2 6.2 6 0 0 6 6 6 0 UME (NUC010) domain RTP1_C1 PF10363.9 EDO06347.1 - 1.3 9.2 6.7 22 5.3 0.0 5.9 7 0 0 7 7 7 0 Required for nuclear transport of RNA pol II C-terminus 1 Got1 PF04178.12 EDO06350.1 - 2.3e-10 40.9 15.1 2.9e-10 40.6 15.1 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family INCENP_ARK-bind PF03941.15 EDO06352.1 - 0.044 13.7 0.1 0.085 12.8 0.1 1.5 1 0 0 1 1 1 0 Inner centromere protein, ARK binding region RBFA PF02033.18 EDO06354.1 - 2.5e-08 34.3 0.0 3.9e-08 33.7 0.0 1.3 1 1 0 1 1 1 1 Ribosome-binding factor A CBFD_NFYB_HMF PF00808.23 EDO06354.1 - 0.11 12.8 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TPD52 PF04201.15 EDO06354.1 - 0.12 12.0 0.2 0.15 11.6 0.2 1.2 1 0 0 1 1 1 0 Tumour protein D52 family MMR_HSR1 PF01926.23 EDO06355.1 - 2.4e-13 50.2 0.0 1.2e-12 48.0 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 EDO06355.1 - 2.5e-05 23.7 0.0 8.1e-05 22.0 0.0 1.8 2 0 0 2 2 2 1 AIG1 family FeoB_N PF02421.18 EDO06355.1 - 7.1e-05 22.4 0.0 0.00013 21.6 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EDO06355.1 - 0.007 16.4 0.0 0.11 12.6 0.0 2.4 2 1 0 2 2 2 1 Dynamin family Ribosomal_S16 PF00886.19 EDO06355.1 - 0.11 12.6 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein S16 Acetyltransf_1 PF00583.25 EDO06356.1 - 3.9e-06 27.1 0.1 5.1e-06 26.7 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EDO06356.1 - 0.0012 18.8 0.1 0.0018 18.2 0.1 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 EDO06356.1 - 0.049 13.6 0.1 0.059 13.3 0.1 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Ribosomal_S10 PF00338.22 EDO06357.1 - 1e-23 83.4 0.1 1.5e-23 82.8 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e IMCp PF12314.8 EDO06358.1 - 4.6e-29 100.6 54.2 3.9e-27 94.4 36.5 2.4 1 1 1 2 2 2 2 Inner membrane complex protein ComX PF05952.12 EDO06358.1 - 0.15 12.0 8.0 0.18 11.7 0.9 2.7 2 0 0 2 2 2 0 Bacillus competence pheromone ComX MKT1_C PF12246.8 EDO06359.1 - 4.7e-38 130.8 0.0 5.2e-37 127.4 0.0 2.0 1 1 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 EDO06359.1 - 1.9e-18 66.6 0.0 4.5e-18 65.4 0.0 1.7 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_I PF00867.18 EDO06359.1 - 2e-05 24.9 0.0 3.9e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 EDO06359.1 - 0.00019 21.8 0.0 0.00048 20.6 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain PLD_C PF12357.8 EDO06359.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 Phospholipase D C terminal GTP_EFTU PF00009.27 EDO06360.1 - 2.9e-32 111.8 0.0 4.2e-32 111.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EDO06360.1 - 1.8e-19 69.6 0.0 5.1e-19 68.1 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 EDO06360.1 - 7.3e-18 64.5 0.0 1.4e-17 63.6 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFTUD2 PF16004.5 EDO06360.1 - 1e-09 39.0 5.1 0.00014 22.5 0.3 2.6 1 1 0 2 2 2 2 116 kDa U5 small nuclear ribonucleoprotein component N-terminus GTP_EFTU_D2 PF03144.25 EDO06360.1 - 4.6e-09 36.5 0.1 1.1e-08 35.4 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EDO06360.1 - 2.5e-08 33.9 0.0 4.9e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 EDO06360.1 - 0.0036 17.4 0.0 0.008 16.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EDO06360.1 - 0.026 14.8 0.0 0.084 13.1 0.0 1.9 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 EDO06360.1 - 0.035 13.5 0.0 0.079 12.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein Laminin_G_3 PF13385.6 EDO06361.1 - 1.2e-11 45.0 0.1 3.4e-10 40.3 0.1 2.5 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 EDO06361.1 - 0.002 18.7 0.0 0.0042 17.6 0.0 1.6 1 1 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 EDO06361.1 - 0.022 15.0 0.0 0.04 14.1 0.0 1.4 1 0 0 1 1 1 0 Laminin G domain Sialidase PF02973.16 EDO06361.1 - 0.032 13.7 0.1 6.7 6.2 0.1 2.4 1 1 1 2 2 2 0 Sialidase, N-terminal domain DUF4975 PF16346.5 EDO06361.1 - 0.05 13.7 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4975) Big_5 PF13205.6 EDO06361.1 - 0.054 14.2 0.0 0.25 12.1 0.0 2.0 2 0 0 2 2 2 0 Bacterial Ig-like domain DUF1080 PF06439.11 EDO06361.1 - 0.083 13.0 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) CLP_protease PF00574.23 EDO06362.1 - 1.8e-66 223.5 0.0 2.1e-66 223.3 0.0 1.1 1 0 0 1 1 1 1 Clp protease HSP20 PF00011.21 EDO06363.1 - 5.6e-12 45.7 0.0 1e-11 44.9 0.0 1.4 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EDO06363.1 - 4.2e-05 23.0 0.0 0.00014 21.4 0.0 1.8 1 1 0 1 1 1 1 HSP20-like domain found in ArsA Peptidase_C48 PF02902.19 EDO06364.1 - 4.2e-36 124.8 3.3 6.6e-36 124.2 0.4 2.0 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain DUF4208 PF13907.6 EDO06364.1 - 0.095 13.1 0.1 0.22 12.0 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4208) AAA_2 PF07724.14 EDO06365.1 - 1.4e-54 184.8 0.0 2e-51 174.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EDO06365.1 - 1.2e-33 115.2 0.2 1.2e-33 115.2 0.2 3.3 3 1 0 3 3 2 1 AAA lid domain AAA PF00004.29 EDO06365.1 - 1e-25 90.6 0.0 1.1e-13 51.7 0.0 3.0 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EDO06365.1 - 3.4e-23 81.5 1.5 1.5e-22 79.4 0.7 2.8 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 EDO06365.1 - 2.8e-17 63.0 0.0 1e-11 45.0 0.0 3.7 2 1 1 3 3 3 2 AAA domain (dynein-related subfamily) Clp_N PF02861.20 EDO06365.1 - 2.2e-15 56.5 0.0 1.3e-09 38.0 0.0 3.0 2 0 0 2 2 2 2 Clp amino terminal domain, pathogenicity island component AAA_16 PF13191.6 EDO06365.1 - 1.6e-10 41.6 0.2 0.0002 21.8 0.1 3.9 3 1 0 3 3 2 2 AAA ATPase domain Sigma54_activat PF00158.26 EDO06365.1 - 1.6e-09 37.7 0.0 7.9e-06 25.7 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_14 PF13173.6 EDO06365.1 - 1.7e-08 34.6 0.1 0.02 14.9 0.0 3.6 3 1 0 3 3 3 2 AAA domain AAA_18 PF13238.6 EDO06365.1 - 3.8e-08 33.9 0.2 0.018 15.6 0.0 3.6 3 0 0 3 3 3 2 AAA domain IstB_IS21 PF01695.17 EDO06365.1 - 1.1e-07 31.8 0.0 0.024 14.3 0.0 3.0 3 0 0 3 3 2 2 IstB-like ATP binding protein AAA_22 PF13401.6 EDO06365.1 - 1.3e-06 28.7 2.7 0.13 12.5 0.1 4.5 4 1 0 4 4 3 2 AAA domain TniB PF05621.11 EDO06365.1 - 2.5e-06 27.0 0.1 0.018 14.5 0.1 3.6 2 1 0 2 2 2 1 Bacterial TniB protein RuvB_N PF05496.12 EDO06365.1 - 2e-05 24.4 1.6 0.95 9.2 0.0 4.3 3 1 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 EDO06365.1 - 3.5e-05 23.4 0.0 0.08 12.5 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region Mg_chelatase PF01078.21 EDO06365.1 - 4.1e-05 23.0 0.0 0.25 10.7 0.0 3.4 2 1 0 3 3 3 1 Magnesium chelatase, subunit ChlI Roc PF08477.13 EDO06365.1 - 5e-05 23.5 0.0 0.17 12.1 0.0 2.8 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Torsin PF06309.11 EDO06365.1 - 0.00011 22.3 0.0 0.0028 17.8 0.0 2.6 2 0 0 2 2 2 1 Torsin ATPase_2 PF01637.18 EDO06365.1 - 0.00011 22.1 6.4 1.3 8.8 0.0 4.8 4 2 1 5 5 5 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EDO06365.1 - 0.00015 22.1 0.3 0.39 11.1 0.0 3.1 4 0 0 4 4 2 1 RNA helicase Zeta_toxin PF06414.12 EDO06365.1 - 0.00029 20.2 0.4 0.26 10.5 0.0 3.5 3 0 0 3 3 3 1 Zeta toxin NACHT PF05729.12 EDO06365.1 - 0.00038 20.4 0.0 0.47 10.4 0.0 3.2 2 1 0 2 2 2 1 NACHT domain AAA_24 PF13479.6 EDO06365.1 - 0.0013 18.5 0.0 0.68 9.6 0.0 2.8 2 0 0 2 2 2 1 AAA domain Bac_DnaA PF00308.18 EDO06365.1 - 0.0015 18.4 0.0 1.6 8.5 0.0 3.7 3 0 0 3 3 3 1 Bacterial dnaA protein TsaE PF02367.17 EDO06365.1 - 0.0018 18.2 0.0 1.4 8.9 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EDO06365.1 - 0.0023 18.4 0.6 0.12 12.9 0.0 3.3 3 1 0 3 3 3 1 ABC transporter NTPase_1 PF03266.15 EDO06365.1 - 0.005 16.8 1.8 3 7.7 0.0 4.1 4 0 0 4 4 4 1 NTPase RsgA_GTPase PF03193.16 EDO06365.1 - 0.0085 16.0 0.0 3.9 7.3 0.0 2.9 3 0 0 3 3 2 1 RsgA GTPase PduV-EutP PF10662.9 EDO06365.1 - 0.014 15.1 0.0 0.22 11.3 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ResIII PF04851.15 EDO06365.1 - 0.025 14.6 0.7 1.7 8.6 0.0 3.5 3 1 0 4 4 3 0 Type III restriction enzyme, res subunit AAA_3 PF07726.11 EDO06365.1 - 0.026 14.4 0.0 7.7 6.4 0.0 3.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 EDO06365.1 - 0.028 14.0 0.0 0.24 11.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EDO06365.1 - 0.028 14.6 0.0 15 5.8 0.0 3.3 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EDO06365.1 - 0.036 14.2 0.0 8.7 6.5 0.0 3.0 2 0 0 2 2 2 0 AAA domain Endonuc_Holl PF10107.9 EDO06365.1 - 0.045 13.6 0.2 0.045 13.6 0.2 2.5 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase DUF615 PF04751.14 EDO06365.1 - 0.051 13.5 7.4 18 5.3 5.6 3.5 2 2 0 2 2 2 0 Protein of unknown function (DUF615) SRP54 PF00448.22 EDO06365.1 - 0.079 12.6 0.6 5.8 6.5 0.0 3.2 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain AAA_17 PF13207.6 EDO06365.1 - 0.087 13.2 1.7 4 7.9 0.0 3.8 4 0 0 4 4 2 0 AAA domain DUF87 PF01935.17 EDO06365.1 - 0.12 12.4 2.2 2.5 8.1 0.0 3.4 3 0 0 3 3 3 0 Helicase HerA, central domain AAA_19 PF13245.6 EDO06365.1 - 0.16 12.3 1.6 15 5.9 0.1 3.9 3 1 0 3 3 3 0 AAA domain DUF4558 PF15104.6 EDO06365.1 - 0.17 12.0 2.6 0.46 10.6 2.6 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4558) ABC_tran_CTD PF16326.5 EDO06365.1 - 7.1 7.0 11.0 1.1 9.5 3.9 3.2 2 1 1 3 3 2 0 ABC transporter C-terminal domain VESA1_N PF12785.7 EDO06366.1 - 2.9e-51 174.9 1.7 3.2e-51 174.7 1.7 1.0 1 0 0 1 1 1 1 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO06367.1 - 9.2e-224 743.5 23.7 9.2e-224 743.5 23.7 2.9 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO06368.1 - 1.3e-21 77.1 35.2 4.6e-12 45.7 0.0 4.5 2 1 1 4 4 4 3 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO06369.1 - 2.6e-218 725.5 16.7 2.6e-218 725.5 16.7 2.3 2 0 0 2 2 2 1 Variant erythrocyte surface antigen-1 SesA PF17107.5 EDO06369.1 - 0.043 14.0 5.1 0.61 10.3 0.3 3.0 2 1 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases LXG PF04740.12 EDO06369.1 - 0.063 13.0 8.7 0.36 10.5 1.9 3.4 3 0 0 3 3 3 0 LXG domain of WXG superfamily Hydrolase_6 PF13344.6 EDO06369.1 - 0.08 13.1 0.1 16 5.7 0.0 2.5 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase RPW8 PF05659.11 EDO06369.1 - 0.2 11.4 2.5 3.9 7.2 0.2 2.4 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 AAA_23 PF13476.6 EDO06369.1 - 0.25 11.8 9.6 0.27 11.7 3.4 2.6 2 0 0 2 2 2 0 AAA domain YkyA PF10368.9 EDO06369.1 - 0.27 10.9 11.6 1.5 8.4 3.9 2.3 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein DASH_Duo1 PF08651.10 EDO06369.1 - 0.33 10.8 2.6 11 5.8 0.2 3.5 3 0 0 3 3 3 0 DASH complex subunit Duo1 Fez1 PF06818.15 EDO06369.1 - 0.47 10.9 4.3 0.11 12.9 0.9 1.6 2 0 0 2 2 1 0 Fez1 DUF2564 PF10819.8 EDO06369.1 - 1.2 9.6 3.5 11 6.5 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2564) HsbA PF12296.8 EDO06369.1 - 1.4 9.4 7.8 0.9 10.0 4.7 2.3 2 0 0 2 2 2 0 Hydrophobic surface binding protein A PEP-utilisers_N PF05524.13 EDO06369.1 - 1.4 9.1 4.9 19 5.4 0.3 2.6 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal NPV_P10 PF05531.12 EDO06369.1 - 1.6 9.3 8.3 4.7 7.7 0.6 3.5 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein HAUS-augmin3 PF14932.6 EDO06369.1 - 2.3 7.7 4.8 0.81 9.2 0.2 2.1 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 Laminin_II PF06009.12 EDO06369.1 - 4.4 7.3 6.4 17 5.4 1.2 2.5 2 0 0 2 2 2 0 Laminin Domain II FAM184 PF15665.5 EDO06369.1 - 7 6.4 7.1 14 5.4 1.3 2.2 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B F-box-like_2 PF13013.6 EDO06370.1 - 1.3e-11 44.4 5.1 0.00012 22.0 0.1 3.1 2 1 1 3 3 3 3 F-box-like domain MFS_1 PF07690.16 EDO06373.1 - 1.8e-16 60.0 21.5 1.8e-16 60.0 21.5 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily VESA1_N PF12785.7 EDO06374.1 - 0.13 11.3 52.9 0.029 13.4 33.6 4.3 3 1 1 4 4 4 0 Variant erythrocyte surface antigen-1 DUF4145 PF13643.6 EDO06374.1 - 0.18 12.0 0.0 1.9 8.7 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4145) Rx_N PF18052.1 EDO06374.1 - 0.41 10.9 2.0 2.2 8.6 0.0 2.7 3 0 0 3 3 3 0 Rx N-terminal domain Phage_holin_2_2 PF10746.9 EDO06375.1 - 0.55 9.9 5.6 0.17 11.5 0.3 2.7 2 0 0 2 2 2 0 Phage holin T7 family, holin superfamily II F-box-like_2 PF13013.6 EDO06377.1 - 3.9e-06 26.8 1.7 0.0023 17.9 0.3 2.4 1 1 1 2 2 2 2 F-box-like domain DUF2770 PF10968.8 EDO06377.1 - 0.00061 19.7 0.2 0.14 12.2 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF2770) DUF4927 PF16279.5 EDO06377.1 - 0.0086 17.1 6.0 1.2 10.2 0.8 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4927) Host_attach PF10116.9 EDO06377.1 - 0.17 12.5 0.0 1.4 9.5 0.0 2.2 2 0 0 2 2 2 0 Protein required for attachment to host cells AP2 PF00847.20 EDO06378.1 - 4e-15 55.8 0.0 1.1e-14 54.4 0.0 1.8 1 0 0 1 1 1 1 AP2 domain Ribosomal_L7Ae PF01248.26 EDO06380.1 - 2.7e-16 59.0 0.1 5.1e-16 58.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 EDO06380.1 - 1.4e-05 25.2 0.7 1.8e-05 24.8 0.7 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 Psu PF07455.11 EDO06380.1 - 0.05 13.2 0.0 0.085 12.4 0.0 1.3 1 0 0 1 1 1 0 Phage polarity suppression protein (Psu) Ran_BP1 PF00638.18 EDO06381.1 - 8.6e-40 135.8 1.8 1.4e-39 135.1 1.8 1.3 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 EDO06381.1 - 0.012 15.5 0.8 0.12 12.3 0.8 2.2 1 1 0 1 1 1 0 WH1 domain MMS1_N PF10433.9 EDO06382.1 - 7.4e-151 503.1 0.0 9.7e-151 502.7 0.0 1.1 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EDO06382.1 - 1.9e-72 244.3 0.1 3.7e-71 240.1 0.0 2.9 4 0 0 4 4 4 1 CPSF A subunit region CPW_WPC PF09717.10 EDO06383.1 - 1.4e-71 237.3 48.5 1.2e-13 51.8 6.1 8.0 8 0 0 8 8 8 7 Plasmodium falciparum domain of unknown function (CPW_WPC) CAS_CSE1 PF03378.15 EDO06384.1 - 8.4e-50 169.5 2.1 8.4e-50 169.5 2.1 2.0 3 0 0 3 3 3 1 CAS/CSE protein, C-terminus Cse1 PF08506.10 EDO06384.1 - 1.9e-41 142.1 0.5 1.9e-41 142.1 0.5 1.7 2 0 0 2 2 2 1 Cse1 IBN_N PF03810.19 EDO06384.1 - 0.00033 20.5 0.2 0.036 14.0 0.0 3.6 3 1 0 3 3 3 1 Importin-beta N-terminal domain TAF6_C PF07571.13 EDO06384.1 - 0.08 13.3 0.1 1.3 9.4 0.0 2.7 2 0 0 2 2 2 0 TAF6 C-terminal HEAT repeat domain HEAT PF02985.22 EDO06384.1 - 0.084 13.2 0.0 0.61 10.5 0.0 2.7 1 0 0 1 1 1 0 HEAT repeat Arf PF00025.21 EDO06385.1 - 7.9e-57 191.5 0.0 9.3e-57 191.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EDO06385.1 - 3.9e-11 42.7 0.0 5.3e-08 32.4 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 EDO06385.1 - 2.2e-09 37.5 0.0 4.1e-09 36.7 0.0 1.4 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EDO06385.1 - 2.6e-08 34.0 0.0 3.5e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 EDO06385.1 - 2.5e-07 30.4 0.0 3.2e-07 30.1 0.0 1.3 1 1 0 1 1 1 1 Ras family SRPRB PF09439.10 EDO06385.1 - 1.9e-06 27.4 0.0 2.4e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EDO06385.1 - 9e-06 25.2 0.0 1.1e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF2582 PF10771.9 EDO06385.1 - 0.0041 17.2 0.3 0.014 15.5 0.1 2.0 3 0 0 3 3 2 1 Winged helix-turn-helix domain (DUF2582) AAA_25 PF13481.6 EDO06385.1 - 0.0046 16.6 0.0 0.0064 16.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain GTP_EFTU PF00009.27 EDO06385.1 - 0.0047 16.5 0.0 0.036 13.6 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EDO06385.1 - 0.0095 15.9 0.0 3 7.7 0.0 2.2 1 1 1 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EDO06385.1 - 0.014 15.6 0.1 0.15 12.3 0.1 2.1 1 1 1 2 2 2 0 AAA domain Amidohydro_1 PF01979.20 EDO06385.1 - 0.015 14.6 0.0 0.51 9.6 0.0 2.0 1 1 1 2 2 2 0 Amidohydrolase family AAA_28 PF13521.6 EDO06385.1 - 0.031 14.5 0.0 0.28 11.4 0.0 2.1 1 1 1 2 2 2 0 AAA domain PduV-EutP PF10662.9 EDO06385.1 - 0.042 13.6 0.0 0.085 12.6 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 EDO06385.1 - 0.14 12.0 0.1 1.3 8.9 0.1 2.1 1 1 0 1 1 1 0 NACHT domain cobW PF02492.19 EDO06385.1 - 0.16 11.6 0.0 14 5.2 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SDA1 PF05285.12 EDO06386.1 - 0.42 10.0 3.5 0.67 9.3 3.5 1.2 1 0 0 1 1 1 0 SDA1 Tubulin PF00091.25 EDO06387.1 - 0.087 13.0 0.3 0.11 12.6 0.3 1.2 1 0 0 1 1 1 0 Tubulin/FtsZ family, GTPase domain Maf1 PF09174.10 EDO06388.1 - 4.6e-26 92.0 4.2 5.3e-26 91.8 4.2 1.1 1 0 0 1 1 1 1 Maf1 regulator CRAL_TRIO PF00650.20 EDO06389.1 - 5.7e-28 97.6 0.2 9.7e-28 96.9 0.2 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDO06389.1 - 0.0014 18.8 0.6 0.006 16.8 0.6 2.2 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain LETM1 PF07766.13 EDO06390.1 - 5.4e-82 275.1 13.0 5.4e-82 275.1 13.0 2.4 2 1 0 2 2 2 1 LETM1-like protein DUF2340 PF10209.9 EDO06390.1 - 0.22 12.0 2.8 0.3 11.5 0.8 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2340) 7TMR-HDED PF07697.11 EDO06390.1 - 9.2 6.3 16.7 74 3.4 11.1 3.1 2 1 0 2 2 2 0 7TM-HD extracellular Memo PF01875.17 EDO06391.1 - 8.5e-47 159.5 1.1 1.1e-41 142.8 0.0 2.7 1 1 2 3 3 3 2 Memo-like protein Pkinase PF00069.25 EDO06393.1 - 1.4e-71 241.0 0.0 2e-71 240.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO06393.1 - 1e-36 126.6 0.0 1.9e-36 125.7 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO06393.1 - 2e-06 27.3 0.0 4.6e-06 26.2 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EDO06393.1 - 0.0015 17.5 0.1 0.0041 16.1 0.1 1.8 1 1 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 EDO06393.1 - 0.0045 16.6 0.1 0.0078 15.8 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 EDO06393.1 - 0.055 12.8 0.1 0.09 12.1 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDO06393.1 - 0.061 13.2 0.3 1.1 9.1 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Mito_carr PF00153.27 EDO06394.1 - 6.6e-34 115.7 3.1 1e-12 47.8 0.0 3.3 2 1 1 3 3 3 3 Mitochondrial carrier protein DUF3561 PF12084.8 EDO06394.1 - 0.1 12.6 2.3 0.36 10.9 0.8 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3561) JTB PF05439.12 EDO06394.1 - 0.12 12.4 0.0 0.34 11.0 0.0 1.7 2 0 0 2 2 2 0 Jumping translocation breakpoint protein (JTB) BTB_2 PF02214.22 EDO06395.1 - 5.3e-14 52.3 0.1 2e-13 50.5 0.0 1.9 2 1 0 2 2 2 1 BTB/POZ domain TH1 PF04858.13 EDO06396.1 - 1.7e-12 46.8 7.2 2.5e-06 26.4 1.7 3.4 3 1 0 3 3 3 3 TH1 protein FH2 PF02181.23 EDO06397.1 - 1.1e-65 222.3 0.0 1.8e-65 221.5 0.0 1.3 1 0 0 1 1 1 1 Formin Homology 2 Domain TPR_12 PF13424.6 EDO06397.1 - 6.3e-08 32.8 0.1 0.0012 19.1 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 EDO06397.1 - 8.4e-06 25.5 0.0 1.3 9.0 0.0 4.2 3 0 0 3 3 3 2 Tetratricopeptide repeat AIP3 PF03915.13 EDO06397.1 - 0.02 14.0 0.1 0.042 12.9 0.1 1.5 1 0 0 1 1 1 0 Actin interacting protein 3 SpoVR PF04293.13 EDO06397.1 - 0.061 12.0 0.0 0.11 11.2 0.0 1.3 1 0 0 1 1 1 0 SpoVR like protein TPR_1 PF00515.28 EDO06397.1 - 0.066 13.1 0.5 2.7 8.0 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF5113 PF17140.4 EDO06397.1 - 0.2 11.5 1.3 1.3 8.8 0.0 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF5113) CPW_WPC PF09717.10 EDO06398.1 - 2.2e-32 111.8 18.5 1.2e-16 61.4 2.2 2.2 2 0 0 2 2 2 2 Plasmodium falciparum domain of unknown function (CPW_WPC) CSTF2_hinge PF14327.6 EDO06399.1 - 1.2e-16 60.9 0.7 2.5e-16 59.9 0.7 1.5 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 partial_CstF PF15861.5 EDO06399.1 - 0.0016 18.1 0.4 0.011 15.5 0.0 2.1 2 0 0 2 2 2 1 Partial cleavage stimulation factor domain Peptidase_M17 PF00883.21 EDO06400.1 - 5e-106 354.5 0.2 6.1e-106 354.2 0.2 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 EDO06400.1 - 0.13 12.1 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 Cytosol aminopeptidase family, N-terminal domain DEAD PF00270.29 EDO06402.1 - 5.9e-49 166.2 0.0 3.8e-48 163.6 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO06402.1 - 9.7e-31 106.4 0.0 8.2e-30 103.4 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO06402.1 - 0.00012 22.2 0.0 0.00029 20.9 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EDO06402.1 - 0.0013 18.0 0.0 0.002 17.4 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_19 PF13245.6 EDO06402.1 - 0.018 15.4 0.0 3.5 8.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain SPOC PF07744.13 EDO06403.1 - 1.1e-15 57.8 0.0 1.8e-15 57.2 0.0 1.2 1 0 0 1 1 1 1 SPOC domain MTS PF05175.14 EDO06404.1 - 1.5e-05 24.6 0.1 0.0003 20.4 0.1 2.4 2 1 0 2 2 2 1 Methyltransferase small domain Methyltransf_24 PF13578.6 EDO06404.1 - 0.0037 18.3 0.0 0.0071 17.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 EDO06404.1 - 0.015 15.0 0.0 0.035 13.7 0.0 1.6 2 0 0 2 2 2 0 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 EDO06404.1 - 0.04 14.6 0.1 0.19 12.5 0.1 2.1 1 1 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 EDO06404.1 - 0.051 13.3 0.0 0.07 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EDO06404.1 - 0.055 13.3 0.0 0.099 12.4 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.7 EDO06404.1 - 0.061 13.2 0.0 1.8 8.5 0.0 2.6 2 1 0 2 2 2 0 Methyltransferase domain Met_10 PF02475.16 EDO06404.1 - 0.12 12.1 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_23 PF13489.6 EDO06404.1 - 0.14 12.0 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 EDO06404.1 - 0.22 10.8 0.5 2.3 7.6 0.5 2.0 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Baculo_PEP_C PF04513.12 EDO06406.1 - 0.0089 16.1 0.2 0.55 10.3 0.1 3.0 3 0 0 3 3 3 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.11 EDO06406.1 - 0.093 13.0 0.5 1.1 9.6 0.2 2.9 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) SHE3 PF17078.5 EDO06406.1 - 0.13 11.9 4.6 2.2 8.0 2.5 2.5 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 Baculo_p24 PF05073.12 EDO06406.1 - 0.15 11.9 2.0 0.64 9.8 1.0 2.6 1 1 0 1 1 1 0 Baculovirus P24 capsid protein Dynactin_p22 PF07426.11 EDO06406.1 - 0.18 11.7 5.6 12 5.7 0.1 4.0 4 0 0 4 4 4 0 Dynactin subunit p22 Tim54 PF11711.8 EDO06407.1 - 0.47 9.2 4.0 0.88 8.3 4.0 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 COX4 PF02936.14 EDO06408.1 - 0.00025 21.1 0.4 0.00042 20.3 0.1 1.5 2 0 0 2 2 2 1 Cytochrome c oxidase subunit IV Nas2_N PF18265.1 EDO06410.1 - 6.8e-31 106.0 0.8 8.3e-31 105.7 0.8 1.1 1 0 0 1 1 1 1 Nas2 N_terminal domain Polbeta PF18765.1 EDO06410.1 - 0.046 13.8 0.1 0.093 12.8 0.0 1.6 1 1 1 2 2 2 0 Polymerase beta, Nucleotidyltransferase DUF4760 PF15956.5 EDO06410.1 - 0.069 13.3 0.2 0.071 13.2 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4760) RRM_1 PF00076.22 EDO06411.1 - 0.00058 19.6 0.0 0.0012 18.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_S17_N PF16205.5 EDO06412.1 - 3.8e-29 100.9 1.0 7.4e-29 99.9 1.0 1.5 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 EDO06412.1 - 1.7e-24 85.7 0.2 3.6e-24 84.7 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein S17 L51_S25_CI-B8 PF05047.16 EDO06413.1 - 0.00015 21.6 0.0 0.00026 20.8 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain LysR_substrate PF03466.20 EDO06413.1 - 0.054 12.8 0.1 0.091 12.1 0.1 1.3 1 0 0 1 1 1 0 LysR substrate binding domain DUF1754 PF08555.10 EDO06415.1 - 0.017 15.9 0.3 0.017 15.9 0.3 1.8 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) HA2 PF04408.23 EDO06416.1 - 4.2e-19 68.8 0.1 8.1e-19 67.9 0.1 1.4 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EDO06416.1 - 2.2e-15 56.8 0.0 4.3e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EDO06416.1 - 3.2e-13 50.0 0.0 7.3e-12 45.6 0.0 2.6 1 1 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDO06416.1 - 6e-08 32.7 0.5 2.5e-07 30.6 0.1 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDO06416.1 - 1.4e-07 31.9 0.1 3.4e-07 30.6 0.1 1.6 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EDO06416.1 - 0.00037 21.0 0.0 0.00099 19.6 0.0 1.8 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 EDO06416.1 - 0.00083 19.1 0.1 0.0022 17.7 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain Helicase_RecD PF05127.14 EDO06416.1 - 0.0013 18.7 0.0 0.0049 16.8 0.0 2.0 3 0 0 3 3 2 1 Helicase DUF2075 PF09848.9 EDO06416.1 - 0.0013 18.0 0.0 0.0024 17.2 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 EDO06416.1 - 0.0027 17.4 0.0 0.0058 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EDO06416.1 - 0.0055 15.8 0.1 0.011 14.8 0.1 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein RsgA_GTPase PF03193.16 EDO06416.1 - 0.0058 16.5 0.0 0.014 15.3 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase Flavi_DEAD PF07652.14 EDO06416.1 - 0.012 15.6 0.1 0.035 14.1 0.0 1.8 2 0 0 2 2 1 0 Flavivirus DEAD domain NACHT PF05729.12 EDO06416.1 - 0.012 15.5 0.0 0.049 13.6 0.0 2.0 2 1 0 2 2 2 0 NACHT domain cobW PF02492.19 EDO06416.1 - 0.013 15.1 0.0 0.034 13.7 0.0 1.7 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 EDO06416.1 - 0.013 15.2 0.0 0.026 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EDO06416.1 - 0.017 15.6 0.9 0.072 13.6 1.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EDO06416.1 - 0.025 14.9 0.0 0.055 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EDO06416.1 - 0.033 14.2 0.1 0.29 11.1 0.1 2.5 2 1 0 2 2 2 0 AAA domain DAP3 PF10236.9 EDO06416.1 - 0.06 12.5 0.0 0.13 11.4 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 EDO06416.1 - 0.066 13.6 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain VirE PF05272.11 EDO06416.1 - 0.073 12.8 0.1 0.98 9.1 0.0 2.2 2 0 0 2 2 2 0 Virulence-associated protein E NB-ARC PF00931.22 EDO06416.1 - 0.082 12.1 0.0 0.21 10.7 0.0 1.7 1 0 0 1 1 1 0 NB-ARC domain Zeta_toxin PF06414.12 EDO06416.1 - 0.13 11.6 0.0 0.25 10.6 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin DUF87 PF01935.17 EDO06416.1 - 0.14 12.3 0.8 3 7.9 0.3 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_33 PF13671.6 EDO06416.1 - 0.17 12.0 0.0 0.33 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EDO06416.1 - 0.42 10.5 2.2 0.44 10.4 0.4 2.1 2 1 0 2 2 1 0 NTPase Cdd1 PF11731.8 EDO06417.1 - 0.12 12.6 0.1 17 5.8 0.0 2.2 2 0 0 2 2 2 0 Pathogenicity locus IPP-2 PF04979.14 EDO06418.1 - 1.6e-08 35.4 10.0 2.2e-06 28.4 10.0 2.3 1 1 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) Longin PF13774.6 EDO06419.1 - 4.3e-16 58.7 0.1 7.2e-16 58.0 0.1 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 EDO06419.1 - 1.2e-06 28.3 0.5 1.2e-06 28.3 0.5 1.7 2 0 0 2 2 2 1 Synaptobrevin Cpn60_TCP1 PF00118.24 EDO06420.1 - 1.8e-152 508.5 6.7 2e-152 508.3 6.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family UQ_con PF00179.26 EDO06421.1 - 5.1e-47 159.1 0.1 5.8e-47 158.9 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EDO06421.1 - 0.025 14.9 0.1 0.031 14.6 0.1 1.3 1 1 0 1 1 1 0 RWD domain Exo_endo_phos PF03372.23 EDO06422.1 - 7.1e-12 45.3 0.0 2.3e-11 43.7 0.0 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DEAD PF00270.29 EDO06423.1 - 6.7e-19 68.3 0.3 7.4e-18 64.9 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO06423.1 - 1.8e-15 57.3 2.4 8.4e-15 55.1 0.6 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF747 PF05346.11 EDO06424.1 - 1.6e-112 376.2 15.8 2e-112 375.8 15.8 1.1 1 0 0 1 1 1 1 Eukaryotic membrane protein family DNA_pol_E_B PF04042.16 EDO06425.1 - 2.8e-21 75.8 0.1 3.3e-21 75.6 0.1 1.1 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B RecA PF00154.21 EDO06427.1 - 0.0075 15.8 0.0 0.012 15.1 0.0 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein Rad51 PF08423.11 EDO06427.1 - 0.045 13.0 0.0 0.076 12.3 0.0 1.3 1 0 0 1 1 1 0 Rad51 DnaJ_C PF01556.18 EDO06428.1 - 8.4e-19 68.1 0.0 1.8e-18 67.0 0.0 1.6 1 1 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 EDO06428.1 - 1.2e-08 35.2 15.7 2.2e-08 34.3 15.7 1.5 1 0 0 1 1 1 1 DnaJ central domain DnaJ PF00226.31 EDO06428.1 - 2.8e-08 33.7 0.5 1e-07 32.0 0.5 2.0 1 1 0 1 1 1 1 DnaJ domain LPD39 PF18858.1 EDO06428.1 - 0.034 14.3 0.2 0.055 13.5 0.2 1.2 1 0 0 1 1 1 0 Large polyvalent protein associated domain 39 Anti-TRAP PF15777.5 EDO06428.1 - 4.2 7.4 12.3 1.7 8.6 2.4 3.2 1 1 3 4 4 4 0 Tryptophan RNA-binding attenuator protein inhibitory protein Fis1_TPR_C PF14853.6 EDO06429.1 - 7e-12 45.2 0.6 7e-12 45.2 0.6 2.0 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_2 PF07719.17 EDO06429.1 - 1.7e-07 30.8 0.8 0.00015 21.6 0.1 3.6 3 1 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_N PF14852.6 EDO06429.1 - 3.2e-06 26.7 0.0 6.1e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_6 PF13174.6 EDO06429.1 - 4.2e-05 23.9 1.4 0.003 18.1 0.1 3.4 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDO06429.1 - 0.00019 21.9 0.2 0.00042 20.8 0.2 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO06429.1 - 0.00029 21.0 0.8 0.00053 20.1 0.8 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EDO06429.1 - 0.0011 19.0 2.6 0.0024 18.0 1.8 1.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EDO06429.1 - 0.0018 18.0 0.9 0.01 15.6 0.0 2.7 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDO06429.1 - 0.0057 17.4 3.8 0.019 15.7 0.4 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDO06429.1 - 0.016 15.9 0.3 0.25 12.0 0.0 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 EDO06429.1 - 0.02 15.2 3.5 0.24 11.7 1.1 2.7 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EDO06429.1 - 0.29 11.2 3.2 0.76 9.9 0.2 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Ribosomal_L39 PF00832.20 EDO06430.1 - 7.1e-21 73.6 12.8 8.1e-21 73.4 12.8 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein DUF2439 PF10382.9 EDO06432.1 - 1.3e-08 35.1 0.2 4.9e-08 33.2 0.2 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF2439) Ribosomal_L9_N PF01281.19 EDO06434.1 - 3.3e-15 55.4 0.0 7.5e-15 54.2 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L9, N-terminal domain PUL PF08324.11 EDO06435.1 - 2e-16 60.1 0.4 2.5e-16 59.8 0.4 1.1 1 0 0 1 1 1 1 PUL domain WD40 PF00400.32 EDO06436.1 - 1.7e-18 66.6 7.8 1.4e-05 25.7 0.4 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat PQQ_3 PF13570.6 EDO06436.1 - 0.081 13.4 0.0 35 5.0 0.0 3.7 3 1 0 3 3 3 0 PQQ-like domain IGPS PF00218.21 EDO06437.1 - 1.2e-22 80.3 0.0 2.2e-22 79.5 0.0 1.3 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase FMN_dh PF01070.18 EDO06437.1 - 0.0041 16.2 1.8 0.065 12.3 2.0 2.3 1 1 1 2 2 2 2 FMN-dependent dehydrogenase NMO PF03060.15 EDO06437.1 - 0.0065 15.9 0.6 4.1 6.7 0.1 3.1 3 0 0 3 3 3 2 Nitronate monooxygenase His_biosynth PF00977.21 EDO06437.1 - 0.024 14.1 0.1 0.054 12.9 0.1 1.7 1 0 0 1 1 1 0 Histidine biosynthesis protein DUF900 PF05990.12 EDO06439.1 - 5.6e-13 48.9 0.0 1.3e-11 44.5 0.0 2.3 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_6 PF12697.7 EDO06439.1 - 0.06 13.9 0.1 0.1 13.2 0.1 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family RRM_1 PF00076.22 EDO06441.1 - 2e-18 66.0 0.0 3.3e-18 65.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Arr-ms PF12120.8 EDO06441.1 - 0.047 13.9 0.1 0.63 10.3 0.0 2.5 3 0 0 3 3 3 0 Rifampin ADP-ribosyl transferase OB_RNB PF08206.11 EDO06441.1 - 0.13 11.9 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 Ribonuclease B OB domain RTP1_C1 PF10363.9 EDO06442.1 - 0.018 15.2 0.7 0.38 10.9 0.0 2.7 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 zf-MIZ PF02891.20 EDO06443.1 - 2.7e-20 71.8 3.3 8.1e-20 70.3 3.3 1.8 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 EDO06443.1 - 2.1e-05 24.2 1.6 4.5e-05 23.2 1.6 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit PHD PF00628.29 EDO06443.1 - 0.064 13.2 16.6 0.084 12.8 7.2 2.5 2 0 0 2 2 2 0 PHD-finger PHD_4 PF16866.5 EDO06443.1 - 2.7 8.1 11.5 13 6.0 3.6 2.9 2 1 0 2 2 2 0 PHD-finger M16C_assoc PF08367.11 EDO06444.1 - 1e-40 139.5 2.1 1.7e-40 138.7 0.8 1.9 2 0 0 2 2 2 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 EDO06444.1 - 6.5e-18 65.4 0.0 8.8e-16 58.4 0.0 3.2 3 0 0 3 3 3 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EDO06444.1 - 4.3e-09 36.5 0.0 1.2e-07 31.9 0.0 2.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Ion_trans_2 PF07885.16 EDO06445.1 - 5.2e-11 42.4 3.4 2e-10 40.4 2.7 2.2 2 0 0 2 2 2 1 Ion channel BK_channel_a PF03493.18 EDO06445.1 - 3.6e-06 27.1 0.0 9.1e-05 22.6 0.1 2.7 3 0 0 3 3 3 1 Calcium-activated BK potassium channel alpha subunit SNF2_N PF00176.23 EDO06446.1 - 5.6e-60 202.9 0.0 1.4e-59 201.6 0.0 1.5 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDO06446.1 - 8.8e-19 67.9 0.0 3.8e-18 65.9 0.0 2.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EDO06446.1 - 9.2e-06 25.0 0.1 2.1e-05 23.9 0.1 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 EDO06446.1 - 0.00013 22.0 0.6 0.0012 18.8 0.1 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ETF_QO PF05187.13 EDO06446.1 - 0.12 12.5 0.0 0.4 10.8 0.0 1.9 1 0 0 1 1 1 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S AAA PF00004.29 EDO06447.1 - 9e-45 152.3 0.0 3.3e-44 150.5 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO06447.1 - 6.8e-11 41.8 0.1 1.7e-10 40.5 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EDO06447.1 - 1.8e-09 37.4 0.1 9.1e-09 35.1 0.0 2.1 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 EDO06447.1 - 8.3e-09 35.6 0.1 3.1e-08 33.7 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EDO06447.1 - 2.2e-07 31.1 0.0 7.4e-07 29.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EDO06447.1 - 2e-06 28.3 0.7 0.00059 20.3 0.0 2.6 2 1 1 3 3 2 1 AAA ATPase domain AAA_18 PF13238.6 EDO06447.1 - 1.3e-05 25.7 0.0 0.00018 22.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 EDO06447.1 - 3e-05 23.8 0.0 8.8e-05 22.3 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 EDO06447.1 - 5.1e-05 22.5 0.0 0.00014 21.1 0.0 1.8 2 1 0 2 2 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EDO06447.1 - 6.5e-05 23.2 0.9 0.0092 16.3 0.0 2.7 1 1 1 2 2 2 1 AAA domain AAA_28 PF13521.6 EDO06447.1 - 0.0004 20.6 0.0 0.00086 19.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EDO06447.1 - 0.0013 19.1 0.0 0.004 17.5 0.0 1.9 2 0 0 2 2 1 1 RNA helicase Mg_chelatase PF01078.21 EDO06447.1 - 0.0015 18.0 0.5 0.0049 16.3 0.1 1.9 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EDO06447.1 - 0.0021 17.8 0.1 0.007 16.1 0.0 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_33 PF13671.6 EDO06447.1 - 0.0023 18.1 0.0 0.0056 16.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 EDO06447.1 - 0.0023 17.2 0.3 0.015 14.5 0.0 2.3 3 1 1 4 4 4 1 TIP49 P-loop domain TsaE PF02367.17 EDO06447.1 - 0.0029 17.6 0.0 0.0055 16.7 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 EDO06447.1 - 0.0039 17.1 0.0 0.041 13.8 0.0 2.4 3 0 0 3 3 3 1 NTPase Prefoldin_2 PF01920.20 EDO06447.1 - 0.0059 16.5 1.5 0.011 15.6 1.5 1.5 1 0 0 1 1 1 1 Prefoldin subunit Sigma54_activat PF00158.26 EDO06447.1 - 0.0065 16.2 0.2 0.12 12.1 0.0 2.6 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_25 PF13481.6 EDO06447.1 - 0.0082 15.7 0.3 0.025 14.2 0.2 1.8 1 1 1 2 2 2 1 AAA domain AAA_14 PF13173.6 EDO06447.1 - 0.0082 16.2 0.1 0.046 13.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EDO06447.1 - 0.0085 16.0 0.2 0.12 12.3 0.1 2.4 2 0 0 2 2 2 1 NACHT domain AAA_3 PF07726.11 EDO06447.1 - 0.0097 15.8 0.0 0.03 14.2 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EDO06447.1 - 0.011 15.5 0.0 0.032 14.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 EDO06447.1 - 0.022 13.9 0.1 0.059 12.5 0.0 1.7 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_7 PF12775.7 EDO06447.1 - 0.032 13.7 0.1 0.16 11.4 0.1 2.0 1 1 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 EDO06447.1 - 0.034 13.5 0.0 5.6 6.3 0.0 2.5 2 0 0 2 2 2 0 Bacterial TniB protein AAA_30 PF13604.6 EDO06447.1 - 0.05 13.3 0.3 0.14 11.9 0.2 1.7 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.6 EDO06447.1 - 0.071 13.5 0.0 0.25 11.8 0.0 2.0 2 0 0 2 2 1 0 AAA domain GrpE PF01025.19 EDO06447.1 - 0.099 12.3 1.4 0.25 11.0 0.3 2.1 2 0 0 2 2 2 0 GrpE Zeta_toxin PF06414.12 EDO06447.1 - 0.11 11.8 0.0 0.23 10.7 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin IPT PF01745.16 EDO06447.1 - 0.11 11.8 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 Isopentenyl transferase Sigma54_activ_2 PF14532.6 EDO06447.1 - 0.12 12.5 0.0 0.29 11.3 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain DUF1664 PF07889.12 EDO06447.1 - 0.12 12.4 0.4 0.29 11.2 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) ATPase PF06745.13 EDO06447.1 - 0.14 11.5 0.9 1.4 8.3 0.0 2.6 3 0 0 3 3 3 0 KaiC ADIP PF11559.8 EDO06447.1 - 0.18 11.9 3.7 0.43 10.7 3.7 1.6 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding HIP1_clath_bdg PF16515.5 EDO06447.1 - 0.23 12.1 2.6 1.4 9.5 1.6 2.2 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 NB-ARC PF00931.22 EDO06447.1 - 1.2 8.3 3.2 0.58 9.3 0.1 2.0 3 0 0 3 3 3 0 NB-ARC domain YycI PF09648.10 EDO06448.1 - 0.0098 15.5 1.3 0.015 14.9 1.3 1.2 1 0 0 1 1 1 1 YycH protein Adenylsucc_synt PF00709.21 EDO06449.1 - 2.6e-150 501.0 0.0 3e-150 500.8 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase Haem_oxygenas_2 PF14518.6 EDO06449.1 - 0.034 13.9 0.2 0.087 12.6 0.2 1.6 1 0 0 1 1 1 0 Iron-containing redox enzyme RRM_1 PF00076.22 EDO06450.1 - 6.7e-34 115.5 2.2 1.4e-18 66.4 0.0 4.9 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDO06450.1 - 1.7e-06 27.8 0.1 0.0075 16.1 0.1 3.6 4 1 0 4 4 4 2 Occluded RNA-recognition motif RRM_7 PF16367.5 EDO06450.1 - 0.0078 16.3 0.0 0.27 11.4 0.0 2.7 2 1 0 2 2 2 1 RNA recognition motif BRAP2 PF07576.12 EDO06450.1 - 0.01 16.0 0.0 2.4 8.4 0.0 3.2 3 0 0 3 3 3 0 BRCA1-associated protein 2 Smg4_UPF3 PF03467.15 EDO06450.1 - 0.12 12.3 0.0 0.26 11.3 0.0 1.6 2 0 0 2 2 2 0 Smg-4/UPF3 family AhpC-TSA PF00578.21 EDO06451.1 - 2e-35 121.4 0.0 4.5e-35 120.3 0.0 1.5 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 EDO06451.1 - 3.4e-15 56.1 0.0 4.1e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EDO06451.1 - 3.5e-13 49.2 0.1 6.8e-13 48.2 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin SCO1-SenC PF02630.14 EDO06451.1 - 0.01 15.7 0.2 0.022 14.7 0.2 1.5 1 0 0 1 1 1 0 SCO1/SenC GN3L_Grn1 PF08701.11 EDO06452.1 - 1.5e-08 34.6 14.3 1.5e-08 34.6 14.3 1.4 2 0 0 2 2 2 1 GNL3L/Grn1 putative GTPase Thump_like PF18096.1 EDO06452.1 - 0.058 13.3 2.0 0.068 13.1 1.6 1.5 1 1 0 1 1 1 0 THUMP domain-like LexA_DNA_bind PF01726.16 EDO06452.1 - 0.096 12.5 1.1 0.21 11.4 0.4 1.8 2 0 0 2 2 2 0 LexA DNA binding domain VCBS PF13517.6 EDO06453.1 - 8.5e-27 93.5 6.8 5.7e-09 36.4 0.0 6.5 5 2 3 8 8 8 7 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 EDO06453.1 - 2.6e-12 46.6 15.5 0.031 14.4 0.0 7.3 7 0 0 7 7 7 5 FG-GAP repeat TcdB_toxin_midN PF12256.8 EDO06453.1 - 5.6e-05 22.6 0.2 2.2 7.6 0.0 5.0 4 1 0 5 5 5 2 Insecticide toxin TcdB middle/N-terminal region Insulin_TMD PF17870.1 EDO06453.1 - 0.19 11.8 1.1 0.35 11.0 0.2 1.9 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment Med2 PF11214.8 EDO06455.1 - 0.004 17.3 0.4 0.011 15.9 0.4 1.7 1 0 0 1 1 1 1 Mediator complex subunit 2 Pre-PUA PF17832.1 EDO06456.1 - 3.2e-25 88.6 0.0 5e-25 88.0 0.0 1.3 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 EDO06456.1 - 1.5e-16 60.1 0.0 2.1e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 PUA domain EAP30 PF04157.16 EDO06457.1 - 9.6e-42 142.9 0.0 1.1e-41 142.6 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family HTH_IclR PF09339.10 EDO06457.1 - 0.026 14.3 0.0 0.069 13.0 0.0 1.8 1 0 0 1 1 1 0 IclR helix-turn-helix domain Ribosomal_L16 PF00252.18 EDO06458.1 - 7.7e-16 58.3 0.0 9.6e-16 58.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e CTP_transf_1 PF01148.20 EDO06459.1 - 4.4e-59 200.4 20.9 1e-57 195.9 15.3 2.2 2 0 0 2 2 2 2 Cytidylyltransferase family Ribosomal_S22 PF08136.11 EDO06459.1 - 0.18 12.2 0.2 0.31 11.4 0.2 1.3 1 0 0 1 1 1 0 30S ribosomal protein subunit S22 family Fer2 PF00111.27 EDO06460.1 - 3.5e-17 62.1 3.8 5e-17 61.6 3.8 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Ribosomal_S19 PF00203.21 EDO06461.1 - 1.6e-32 111.2 0.4 2.2e-32 110.8 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Ctr PF04145.15 EDO06462.1 - 4.7e-13 50.0 23.8 2.6e-09 37.9 3.8 2.5 1 1 1 2 2 2 2 Ctr copper transporter family Ferlin_C PF16165.5 EDO06462.1 - 0.21 11.5 2.4 0.43 10.5 0.0 2.1 2 0 0 2 2 2 0 Ferlin C-terminus DUF4212 PF13937.6 EDO06464.1 - 0.14 12.6 0.2 0.14 12.6 0.2 2.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4212) CBF PF03914.17 EDO06465.1 - 5.6e-11 42.8 0.1 5.6e-11 42.8 0.1 2.4 2 1 0 2 2 2 1 CBF/Mak21 family DUF1877 PF08974.10 EDO06465.1 - 0.0045 17.1 0.1 0.014 15.5 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1877) DUF4692 PF15763.5 EDO06465.1 - 0.08 13.4 4.6 0.16 12.4 4.6 1.4 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) BUD22 PF09073.10 EDO06465.1 - 0.19 11.1 5.8 0.32 10.3 5.8 1.3 1 0 0 1 1 1 0 BUD22 MCM PF00493.23 EDO06468.1 - 5.4e-93 310.2 0.1 8.7e-93 309.5 0.1 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDO06468.1 - 9.4e-24 83.7 0.9 2e-23 82.6 0.9 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EDO06468.1 - 9.9e-24 83.6 0.6 2.1e-23 82.6 0.6 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EDO06468.1 - 1.2e-05 24.8 0.0 7.6e-05 22.2 0.0 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI MCM_N PF14551.6 EDO06468.1 - 7.2e-05 23.3 0.0 0.00026 21.5 0.0 1.9 1 1 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.14 EDO06468.1 - 0.00088 19.3 0.0 0.003 17.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EDO06468.1 - 0.0061 16.4 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RRM_1 PF00076.22 EDO06469.1 - 0.0014 18.4 0.0 0.0028 17.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TetR_C_17 PF17922.1 EDO06469.1 - 0.11 12.5 0.1 0.24 11.5 0.1 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Nup88 PF10168.9 EDO06469.1 - 0.48 8.2 4.3 0.67 7.7 4.3 1.1 1 0 0 1 1 1 0 Nuclear pore component UCH PF00443.29 EDO06470.1 - 6.3e-32 111.1 0.0 9.1e-32 110.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EDO06470.1 - 6.4e-11 42.4 2.2 6.4e-11 42.4 2.2 1.6 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 EDO06470.1 - 8.6e-05 22.3 0.0 0.00027 20.7 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase EPL1 PF10513.9 EDO06471.1 - 0.0046 17.3 0.1 0.0087 16.5 0.1 1.5 1 0 0 1 1 1 1 Enhancer of polycomb-like DUF724 PF05266.14 EDO06472.1 - 0.0059 16.5 4.4 0.0083 16.0 4.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF724) DMPK_coil PF08826.10 EDO06472.1 - 0.029 14.5 1.1 0.054 13.6 0.3 1.8 1 1 1 2 2 2 0 DMPK coiled coil domain like DUF4407 PF14362.6 EDO06472.1 - 0.061 12.7 2.8 0.077 12.3 2.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Dendrin PF15498.6 EDO06472.1 - 0.17 10.6 0.0 0.2 10.3 0.0 1.1 1 0 0 1 1 1 0 Nephrin and CD2AP-binding protein, Dendrin Vert_IL3-reg_TF PF06529.11 EDO06472.1 - 0.26 10.4 3.9 1 8.4 3.8 1.7 1 1 1 2 2 2 0 Vertebrate interleukin-3 regulated transcription factor OmpH PF03938.14 EDO06472.1 - 0.49 10.7 6.2 0.73 10.2 6.2 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) APG6_N PF17675.1 EDO06473.1 - 0.0089 16.6 0.5 0.061 13.9 0.8 1.9 2 0 0 2 2 2 1 Apg6 coiled-coil region CTP_transf_like PF01467.26 EDO06474.1 - 2.2e-45 154.3 0.1 4.6e-24 85.2 0.0 2.4 2 0 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 EDO06474.1 - 0.001 19.0 2.1 0.9 9.4 0.3 3.1 3 0 0 3 3 3 2 FAD synthetase HTH_16 PF12645.7 EDO06474.1 - 0.034 14.2 0.1 1.5 9.0 0.0 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain DUF5639 PF18690.1 EDO06474.1 - 0.059 13.5 0.1 5.6 7.2 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5639) RasGEF_N PF00618.20 EDO06474.1 - 0.15 12.3 0.1 1.2 9.5 0.1 2.4 1 1 0 1 1 1 0 RasGEF N-terminal motif WW PF00397.26 EDO06475.1 - 3.9e-17 62.0 19.1 3.7e-09 36.5 3.9 3.4 3 0 0 3 3 3 2 WW domain FF PF01846.19 EDO06475.1 - 1.4e-11 44.4 4.8 3.9e-06 26.9 0.8 4.3 4 0 0 4 4 4 2 FF domain Glyco_hyd_101C PF17451.2 EDO06475.1 - 0.2 12.0 4.0 8.2 6.8 0.5 2.8 1 1 1 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain ASD1 PF08688.10 EDO06475.1 - 4.6 7.6 12.6 0.29 11.5 3.6 3.0 2 1 0 2 2 2 0 Apx/Shroom domain ASD1 SNAP PF14938.6 EDO06476.1 - 8.1e-75 251.8 12.7 9.8e-75 251.6 12.7 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_7 PF13176.6 EDO06476.1 - 6.9e-09 35.1 8.0 0.043 13.8 0.0 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EDO06476.1 - 3.6e-07 30.4 14.7 0.00049 20.3 0.3 4.5 1 1 4 5 5 5 5 Tetratricopeptide repeat TPR_2 PF07719.17 EDO06476.1 - 3.1e-05 23.8 16.0 0.022 14.9 3.6 5.5 5 2 1 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDO06476.1 - 0.0011 19.6 7.8 13 6.9 0.1 5.4 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 EDO06476.1 - 0.0031 17.3 19.8 0.25 11.2 4.0 5.4 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 EDO06476.1 - 0.0038 16.9 7.1 1.1 9.0 1.9 4.5 3 1 1 4 4 4 1 TPR repeat TPR_8 PF13181.6 EDO06476.1 - 0.024 14.8 11.6 1.5 9.2 0.1 4.5 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 EDO06476.1 - 0.055 13.4 5.5 2.6 8.1 1.6 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EDO06476.1 - 0.54 10.8 11.2 4.1 8.0 0.5 4.4 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDO06476.1 - 0.74 10.5 13.3 4 8.2 0.2 4.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDO06476.1 - 0.75 10.6 8.8 70 4.4 0.2 5.0 4 1 1 5 5 5 0 Tetratricopeptide repeat Clathrin PF00637.20 EDO06476.1 - 1.1 9.2 5.5 9.1 6.1 0.9 3.4 2 1 1 4 4 4 0 Region in Clathrin and VPS MIT PF04212.18 EDO06476.1 - 4 7.6 12.4 27 4.9 2.9 4.3 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain CDP-OH_P_transf PF01066.21 EDO06477.1 - 3.6e-09 37.3 0.6 3.6e-09 37.3 0.6 2.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase GCD14 PF08704.10 EDO06478.1 - 5e-62 209.8 0.3 5.2e-61 206.5 0.0 1.9 1 1 1 2 2 2 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.6 EDO06478.1 - 1.4e-06 28.2 0.0 3.5e-06 26.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.17 EDO06478.1 - 7.2e-05 22.0 0.0 0.00012 21.3 0.0 1.4 1 1 0 1 1 1 1 O-methyltransferase PCMT PF01135.19 EDO06478.1 - 0.0014 18.4 0.1 0.0064 16.3 0.1 1.9 1 1 1 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_24 PF13578.6 EDO06478.1 - 0.0053 17.8 0.0 0.0092 17.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDO06478.1 - 0.029 15.1 0.0 0.049 14.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 EDO06478.1 - 0.051 13.0 0.0 0.082 12.4 0.0 1.4 1 1 0 1 1 1 0 Putative methyltransferase NHL PF01436.21 EDO06478.1 - 0.052 13.6 0.0 16 5.7 0.0 2.5 2 0 0 2 2 2 0 NHL repeat Methyltransf_11 PF08241.12 EDO06478.1 - 0.062 14.0 0.0 0.12 13.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Myb_DNA-bind_6 PF13921.6 EDO06479.1 - 1.2e-18 67.1 1.2 5.9e-08 32.9 0.3 3.4 2 1 1 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EDO06479.1 - 1.2e-18 67.0 2.4 1.5e-08 34.6 1.4 3.4 3 0 0 3 3 3 2 Myb-like DNA-binding domain Rap1_C PF11626.8 EDO06479.1 - 0.049 13.7 0.0 0.12 12.5 0.0 1.8 1 1 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Pkinase PF00069.25 EDO06480.1 - 1.1e-21 77.4 0.0 1.8e-20 73.4 0.0 2.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO06480.1 - 1.1e-11 44.6 0.0 5.5e-11 42.2 0.0 2.1 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDO06480.1 - 0.00063 18.6 0.1 0.00082 18.3 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EDO06480.1 - 0.014 15.3 0.3 0.052 13.5 0.2 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EDO06480.1 - 0.015 14.3 0.0 0.023 13.7 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 EDO06480.1 - 0.091 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Arf PF00025.21 EDO06481.1 - 1e-11 44.6 0.1 7.6e-11 41.8 0.1 1.9 1 1 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EDO06481.1 - 0.00043 19.8 0.1 0.012 15.0 0.0 2.0 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EDO06481.1 - 0.05 13.8 0.0 0.096 12.9 0.0 1.5 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 EDO06481.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 EDO06481.1 - 0.15 11.9 0.3 12 5.8 0.1 2.4 2 0 0 2 2 2 0 NACHT domain MMR_HSR1 PF01926.23 EDO06481.1 - 0.18 11.9 0.4 1.1 9.3 0.4 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase SAS-6_N PF16531.5 EDO06482.1 - 4.2e-20 72.1 0.8 7.2e-20 71.4 0.8 1.4 1 0 0 1 1 1 1 Centriolar protein SAS N-terminal SSB PF00436.25 EDO06483.1 - 2.5e-11 43.5 0.2 3.6e-11 43.0 0.2 1.2 1 0 0 1 1 1 1 Single-strand binding protein family DNA_primase_S PF01896.19 EDO06484.1 - 3.1e-46 157.7 0.4 4.1e-46 157.2 0.4 1.2 1 0 0 1 1 1 1 DNA primase small subunit ATP-synt_Eps PF04627.13 EDO06484.1 - 0.025 14.6 0.0 0.48 10.4 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial ATP synthase epsilon chain CTP_synth_N PF06418.14 EDO06485.1 - 2.3e-106 355.0 0.0 9.1e-106 353.0 0.0 1.8 2 0 0 2 2 2 1 CTP synthase N-terminus GATase PF00117.28 EDO06485.1 - 4.2e-45 153.9 0.0 6.5e-45 153.2 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EDO06485.1 - 0.00055 19.7 0.0 0.0018 18.1 0.0 1.9 1 1 0 1 1 1 1 Peptidase C26 CbiA PF01656.23 EDO06485.1 - 0.015 15.4 0.0 0.024 14.7 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain PA28_beta PF02252.18 EDO06486.1 - 1.3e-56 190.3 2.1 1.3e-56 190.3 2.1 1.6 2 0 0 2 2 2 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.18 EDO06486.1 - 0.0073 16.3 0.4 0.028 14.4 0.0 2.1 2 0 0 2 2 2 1 Proteasome activator pa28 alpha subunit SUI1 PF01253.22 EDO06487.1 - 2.1e-10 41.0 0.0 5.4e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 Translation initiation factor SUI1 PUA PF01472.20 EDO06487.1 - 0.0037 17.2 0.0 0.0094 15.9 0.0 1.8 1 0 0 1 1 1 1 PUA domain SbcD_C PF12320.8 EDO06488.1 - 1.3 9.4 4.5 1.3 9.3 3.0 1.8 1 1 0 1 1 1 0 Type 5 capsule protein repressor C-terminal domain MINDY_DUB PF04424.13 EDO06489.1 - 2.9e-09 36.9 0.1 7.8e-09 35.6 0.1 1.7 1 0 0 1 1 1 1 MINDY deubiquitinase Sec63 PF02889.16 EDO06490.1 - 7.3e-23 81.0 0.0 1e-22 80.6 0.0 1.1 1 0 0 1 1 1 1 Sec63 Brl domain DnaJ PF00226.31 EDO06490.1 - 5.3e-19 68.1 0.5 1.3e-18 66.8 0.1 1.9 2 0 0 2 2 2 1 DnaJ domain SlyX PF04102.12 EDO06491.1 - 4.7e-05 23.9 18.6 0.022 15.4 0.1 5.2 3 1 1 4 4 4 1 SlyX Prefoldin PF02996.17 EDO06491.1 - 0.0052 16.7 1.1 0.0052 16.7 1.1 4.4 2 1 0 3 3 3 1 Prefoldin subunit TolA_bind_tri PF16331.5 EDO06491.1 - 0.019 15.0 17.8 1.5 9.0 0.0 4.7 3 1 1 4 4 4 0 TolA binding protein trimerisation DUF812 PF05667.11 EDO06491.1 - 0.028 13.3 30.4 0.094 11.6 23.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF812) DUF3450 PF11932.8 EDO06491.1 - 0.028 13.7 25.6 0.071 12.4 4.7 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) TPR_MLP1_2 PF07926.12 EDO06491.1 - 0.049 13.7 32.4 0.047 13.8 7.2 3.3 2 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein ATG16 PF08614.11 EDO06491.1 - 0.1 12.8 31.9 0.034 14.4 8.7 3.2 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) TMPIT PF07851.13 EDO06491.1 - 0.11 11.8 22.9 0.46 9.7 5.7 2.4 1 1 1 2 2 2 0 TMPIT-like protein DUF948 PF06103.11 EDO06491.1 - 0.12 12.6 14.8 0.4 11.0 1.2 4.1 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF4349 PF14257.6 EDO06491.1 - 0.15 11.5 11.3 0.24 10.8 7.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4349) MerR-DNA-bind PF09278.11 EDO06491.1 - 0.15 12.6 3.8 19 5.9 0.9 3.6 2 1 1 3 3 3 0 MerR, DNA binding Bacillus_HBL PF05791.11 EDO06491.1 - 0.19 11.6 21.6 0.23 11.2 10.1 2.9 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Spc7 PF08317.11 EDO06491.1 - 0.2 10.5 32.4 0.86 8.4 10.9 2.8 1 1 1 2 2 2 0 Spc7 kinetochore protein HTH_Tnp_Tc3_1 PF11427.8 EDO06491.1 - 0.23 11.4 0.9 0.91 9.4 0.3 2.4 1 1 1 2 2 2 0 Tc3 transposase Fib_alpha PF08702.10 EDO06491.1 - 0.23 11.6 31.5 0.96 9.6 13.2 3.6 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family DUF4407 PF14362.6 EDO06491.1 - 0.27 10.5 19.3 0.46 9.8 10.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) MCPsignal PF00015.21 EDO06491.1 - 0.41 10.4 10.6 0.95 9.2 1.5 3.0 1 1 2 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain FlxA PF14282.6 EDO06491.1 - 0.49 10.4 18.8 0.43 10.6 0.7 3.8 2 2 0 3 3 3 0 FlxA-like protein BLOC1_2 PF10046.9 EDO06491.1 - 0.5 10.7 25.2 1.5 9.1 8.1 3.9 1 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Baculo_PEP_C PF04513.12 EDO06491.1 - 0.68 10.0 18.1 3.6 7.6 6.9 2.7 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus IFT57 PF10498.9 EDO06491.1 - 0.69 8.8 26.6 0.047 12.7 10.8 2.9 1 1 2 3 3 3 0 Intra-flagellar transport protein 57 PKcGMP_CC PF16808.5 EDO06491.1 - 0.75 9.7 17.8 0.38 10.6 1.0 4.4 4 1 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF724 PF05266.14 EDO06491.1 - 2 8.2 25.8 3.7 7.3 13.4 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF724) TMF_TATA_bd PF12325.8 EDO06491.1 - 2.2 8.5 33.3 0.48 10.7 3.1 4.2 1 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding DUF4472 PF14739.6 EDO06491.1 - 2.9 8.7 27.6 0.2 12.4 8.2 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) DUF16 PF01519.16 EDO06491.1 - 4.1 7.9 26.2 0.47 11.0 7.6 3.5 2 1 1 3 3 3 0 Protein of unknown function DUF16 CENP-F_leu_zip PF10473.9 EDO06491.1 - 4.2 7.4 36.2 1 9.4 18.1 3.4 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PI3K_P85_iSH2 PF16454.5 EDO06491.1 - 4.6 6.8 30.6 4.2 7.0 17.0 3.3 1 1 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF3552 PF12072.8 EDO06491.1 - 5.1 6.5 33.3 0.012 15.0 10.1 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) Rho_Binding PF08912.11 EDO06491.1 - 5.5 7.9 26.9 2.8 8.8 5.7 4.4 3 1 1 4 4 4 0 Rho Binding DUF1664 PF07889.12 EDO06491.1 - 5.8 7.0 21.1 0.75 9.8 5.6 3.4 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 EDO06491.1 - 6.6 6.7 26.3 5 7.1 10.9 3.3 1 1 1 3 3 3 0 Laminin Domain II HTH_19 PF12844.7 EDO06491.1 - 7.2 6.7 8.5 1.3 9.1 2.8 2.7 2 1 0 2 2 2 0 Helix-turn-helix domain TIR-like PF10137.9 EDO06491.1 - 7.3 6.6 7.3 0.94 9.5 0.3 2.7 3 0 0 3 3 3 0 Predicted nucleotide-binding protein containing TIR-like domain Atg14 PF10186.9 EDO06491.1 - 8.9 5.3 30.3 36 3.3 22.2 2.9 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2058 PF09831.9 EDO06492.1 - 0.065 13.4 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) TPR_20 PF14561.6 EDO06492.1 - 0.066 13.5 0.1 16 5.9 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat AftA_C PF12249.8 EDO06492.1 - 0.13 11.9 0.0 3.2 7.4 0.0 2.2 2 0 0 2 2 2 0 Arabinofuranosyltransferase A C terminal Solute_trans_a PF03619.16 EDO06493.1 - 4.3e-52 177.3 16.4 5.8e-52 176.8 16.4 1.2 1 0 0 1 1 1 1 Organic solute transporter Ostalpha EKR PF10371.9 EDO06493.1 - 0.26 11.1 0.9 0.47 10.3 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function cNMP_binding PF00027.29 EDO06494.1 - 2.8e-35 120.2 0.1 1.9e-20 72.7 0.0 2.2 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Corona_RPol_N PF06478.13 EDO06494.1 - 0.12 11.4 0.0 0.18 10.8 0.0 1.3 1 0 0 1 1 1 0 Coronavirus RPol N-terminus TAF4 PF05236.14 EDO06498.1 - 0.026 14.3 14.1 0.032 14.0 14.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Borrelia_P83 PF05262.11 EDO06498.1 - 0.038 12.5 15.4 0.039 12.4 15.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein BAF1_ABF1 PF04684.13 EDO06498.1 - 0.34 9.9 10.4 0.38 9.8 10.4 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Asp-B-Hydro_N PF05279.11 EDO06498.1 - 0.59 10.2 18.3 0.72 9.9 18.3 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Neur_chan_memb PF02932.16 EDO06498.1 - 9.7 6.2 11.4 13 5.8 11.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region AP2 PF00847.20 EDO06499.1 - 1.1e-06 28.7 1.1 2.3e-06 27.7 1.1 1.5 1 0 0 1 1 1 1 AP2 domain Acyl-CoA_dh_2 PF08028.11 EDO06499.1 - 0.016 15.5 0.5 11 6.3 0.8 3.1 3 0 0 3 3 3 0 Acyl-CoA dehydrogenase, C-terminal domain SCP_3 PF17844.1 EDO06499.1 - 0.019 14.7 0.1 0.04 13.7 0.1 1.5 1 0 0 1 1 1 0 Bacterial SCP ortholog DUF29 PF01724.16 EDO06499.1 - 0.079 13.2 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF29 DUF503 PF04456.12 EDO06499.1 - 0.25 11.2 0.9 6.5 6.7 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF503) DEAD PF00270.29 EDO06500.1 - 1e-37 129.6 0.0 2.1e-37 128.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO06500.1 - 2e-22 79.6 0.0 2.8e-21 75.9 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EDO06500.1 - 5.7e-06 26.5 0.3 3.3e-05 24.0 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EDO06500.1 - 4.1e-05 23.7 0.5 0.00035 20.6 0.0 2.7 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDO06500.1 - 0.0094 16.2 0.0 0.044 14.1 0.0 2.2 1 0 0 1 1 1 1 AAA domain ERCC3_RAD25_C PF16203.5 EDO06500.1 - 0.012 14.8 0.1 0.033 13.4 0.0 1.8 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase KAsynt_C_assoc PF16197.5 EDO06500.1 - 0.15 12.5 1.0 2.1 8.9 0.2 2.7 3 0 0 3 3 3 0 Ketoacyl-synthetase C-terminal extension DUF749 PF05370.11 EDO06500.1 - 2.6 8.2 7.5 17 5.6 0.4 4.1 3 1 1 4 4 4 0 Domain of unknown function (DUF749) CAF1A PF12253.8 EDO06501.1 - 4.1e-06 26.9 8.0 1.8e-05 24.8 8.0 2.1 1 1 0 1 1 1 1 Chromatin assembly factor 1 subunit A PX PF00787.24 EDO06501.1 - 0.0055 16.7 0.9 33 4.5 0.0 4.1 5 0 0 5 5 5 2 PX domain DEAD PF00270.29 EDO06502.1 - 2.2e-21 76.4 0.0 3.3e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO06502.1 - 1.7e-17 63.7 0.0 5.5e-15 55.7 0.0 2.5 2 0 0 2 2 2 2 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 EDO06502.1 - 4.8e-10 40.0 0.8 1.5e-09 38.5 0.8 1.8 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.15 EDO06502.1 - 1.2e-06 28.7 0.0 7.6e-06 26.0 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit TH1 PF04858.13 EDO06502.1 - 0.12 10.9 0.2 0.19 10.3 0.2 1.2 1 0 0 1 1 1 0 TH1 protein DKCLD PF08068.12 EDO06503.1 - 9.2e-33 112.1 0.5 7.2e-31 106.0 0.2 3.1 3 0 0 3 3 3 1 DKCLD (NUC011) domain TruB_N PF01509.18 EDO06503.1 - 3.9e-24 85.7 0.7 3e-16 60.1 0.1 3.2 1 1 1 2 2 2 2 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 EDO06503.1 - 4e-23 81.3 0.4 7.6e-23 80.4 0.4 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 EDO06503.1 - 2.7e-16 59.3 1.6 5.5e-16 58.3 1.6 1.5 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 EDO06503.1 - 0.015 15.5 0.0 0.034 14.4 0.0 1.6 1 0 0 1 1 1 0 UPF0113 PUA domain Not1 PF04054.15 EDO06504.1 - 9.7e-53 179.4 7.8 9.7e-53 179.4 7.8 2.7 2 1 0 2 2 2 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 EDO06504.1 - 1.8e-34 119.1 0.4 5.7e-34 117.5 0.4 1.8 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 EDO06504.1 - 1.8e-14 53.9 0.8 1.8e-14 53.9 0.8 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3819) Peptidase_C54 PF03416.19 EDO06505.1 - 1.8e-27 96.5 0.0 4.9e-17 62.3 0.0 2.1 1 1 1 2 2 2 2 Peptidase family C54 Peptidase_C78 PF07910.13 EDO06505.1 - 0.033 13.7 0.0 0.052 13.0 0.0 1.3 1 0 0 1 1 1 0 Peptidase family C78 DWNN PF08783.11 EDO06506.1 - 0.024 14.9 0.2 1.1 9.5 0.0 2.9 2 0 0 2 2 2 0 DWNN domain cNMP_binding PF00027.29 EDO06507.1 - 2.8e-30 104.2 0.0 1.3e-11 44.3 0.0 4.5 4 0 0 4 4 4 4 Cyclic nucleotide-binding domain EF-hand_8 PF13833.6 EDO06507.1 - 0.051 13.4 2.6 4 7.4 0.4 3.0 2 0 0 2 2 2 0 EF-hand domain pair ZapB PF06005.12 EDO06507.1 - 0.064 13.7 2.5 0.14 12.6 0.1 2.8 2 1 1 3 3 3 0 Cell division protein ZapB EF-hand_6 PF13405.6 EDO06507.1 - 0.15 12.1 0.8 3.7 7.7 0.0 3.1 3 0 0 3 3 3 0 EF-hand domain PHO4 PF01384.20 EDO06508.1 - 4.5e-97 325.1 20.1 6.5e-97 324.6 20.1 1.2 1 0 0 1 1 1 1 Phosphate transporter family OATP PF03137.20 EDO06509.1 - 0.15 10.3 13.7 0.77 8.0 10.8 2.8 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF872 PF05915.12 EDO06509.1 - 8.7 6.5 7.6 33 4.7 1.5 3.2 1 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) Dpy19 PF10034.9 EDO06510.1 - 6.7e-53 179.9 3.4 3.6e-32 111.4 7.4 2.2 1 1 0 2 2 2 2 Q-cell neuroblast polarisation DUF2070 PF09843.9 EDO06510.1 - 0.096 11.0 6.3 0.17 10.2 6.3 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) SKIP_SNW PF02731.15 EDO06511.1 - 1.8e-63 213.0 6.2 1.8e-63 213.0 6.2 2.4 3 0 0 3 3 3 1 SKIP/SNW domain CAF-1_p150 PF11600.8 EDO06511.1 - 0.035 13.8 16.8 0.079 12.7 16.8 1.5 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal AvrPphF-ORF-2 PF09143.10 EDO06511.1 - 0.68 9.8 3.3 3.5 7.5 0.0 2.6 3 0 0 3 3 3 0 AvrPphF-ORF-2 GBP PF02263.19 EDO06512.1 - 1.5e-12 47.4 3.9 7.9e-09 35.2 0.0 2.9 3 0 0 3 3 3 2 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 EDO06512.1 - 0.086 12.9 1.3 0.29 11.2 0.2 2.6 2 1 0 2 2 2 0 Dynamin family YtxH PF12732.7 EDO06512.1 - 10 6.8 7.9 27 5.4 0.8 3.9 3 1 0 3 3 3 0 YtxH-like protein cwf21 PF08312.12 EDO06513.1 - 0.1 12.8 5.9 0.2 11.8 5.9 1.5 1 0 0 1 1 1 0 cwf21 domain DnaJ-X PF14308.6 EDO06514.1 - 3.4e-26 92.0 0.3 5.5e-25 88.1 0.3 2.3 1 1 0 1 1 1 1 X-domain of DnaJ-containing DnaJ PF00226.31 EDO06514.1 - 3.2e-24 84.8 2.5 7.6e-24 83.6 2.5 1.7 1 0 0 1 1 1 1 DnaJ domain SabA_adhesion PF18304.1 EDO06514.1 - 0.017 14.4 0.7 0.97 8.6 0.1 2.5 2 0 0 2 2 2 0 SabA N-terminal extracellular adhesion domain Synuclein PF01387.17 EDO06514.1 - 0.061 13.5 0.6 0.16 12.2 0.2 2.0 2 0 0 2 2 2 0 Synuclein Glyco_tran_28_C PF04101.16 EDO06515.1 - 9.2e-19 68.0 0.2 1.2e-18 67.7 0.2 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Pneumo_M2 PF07380.11 EDO06515.1 - 0.0039 17.4 0.9 0.011 16.0 0.4 1.9 1 1 1 2 2 2 1 Pneumovirus M2 protein LUC7 PF03194.15 EDO06516.1 - 1.3e-70 237.9 6.7 1.8e-70 237.5 6.7 1.1 1 0 0 1 1 1 1 LUC7 N_terminus rRNA_proc-arch PF13234.6 EDO06517.1 - 6e-46 157.6 4.7 6e-46 157.6 4.7 2.2 2 0 0 2 2 2 1 rRNA-processing arch domain DSHCT PF08148.12 EDO06517.1 - 6e-45 152.8 2.2 7.1e-45 152.6 0.4 2.0 2 0 0 2 2 2 1 DSHCT (NUC185) domain DEAD PF00270.29 EDO06517.1 - 1.2e-18 67.5 0.0 4.4e-18 65.7 0.0 2.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO06517.1 - 1.2e-07 32.1 0.0 4.6e-07 30.2 0.0 2.2 1 1 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EDO06517.1 - 0.0038 17.5 0.0 0.8 10.0 0.0 3.5 2 1 1 3 3 3 1 AAA domain MAT1 PF06391.13 EDO06519.1 - 2.4e-09 37.3 2.2 3.1e-09 36.9 2.2 1.2 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-RING_11 PF17123.5 EDO06519.1 - 0.0091 15.7 0.8 0.016 14.9 0.8 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 EDO06519.1 - 0.044 14.1 0.3 0.08 13.3 0.3 1.4 1 0 0 1 1 1 0 Ring finger domain C2 PF00168.30 EDO06520.1 - 8e-31 106.4 0.0 3.3e-05 24.1 0.0 5.6 5 0 0 5 5 5 5 C2 domain E1-E2_ATPase PF00122.20 EDO06521.1 - 3.1e-52 176.7 0.4 3.1e-52 176.7 0.4 3.1 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EDO06521.1 - 3.8e-45 153.8 3.5 3.8e-45 153.8 3.5 2.3 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EDO06521.1 - 1.8e-21 77.4 2.0 3.3e-20 73.3 2.0 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EDO06521.1 - 1.4e-18 66.4 0.8 3e-18 65.3 0.0 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EDO06521.1 - 2.9e-15 56.1 0.0 5.9e-15 55.1 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EDO06521.1 - 8.2e-06 25.7 2.2 9.7e-05 22.2 1.7 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EDO06521.1 - 0.00016 22.1 0.0 0.00046 20.6 0.0 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase TRM PF02005.16 EDO06522.1 - 1e-92 311.3 0.2 2.4e-72 244.2 0.0 2.1 2 0 0 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase DUF2067 PF09840.9 EDO06522.1 - 0.11 12.0 0.0 0.26 10.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2067) Ras PF00071.22 EDO06523.1 - 7.4e-15 54.9 0.0 6.4e-10 38.9 0.0 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EDO06523.1 - 2.2e-06 27.9 0.0 0.0075 16.5 0.0 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EDO06523.1 - 0.00061 19.7 0.0 0.13 12.1 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EDO06523.1 - 0.0029 17.0 0.0 1.5 8.2 0.0 2.1 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDO06523.1 - 0.031 14.4 0.0 0.19 11.8 0.0 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_7 PF12775.7 EDO06523.1 - 0.089 12.3 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region PduV-EutP PF10662.9 EDO06523.1 - 0.096 12.4 0.0 1.7 8.4 0.0 2.2 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 EDO06523.1 - 0.11 12.3 0.0 3.1 7.7 0.0 2.6 2 1 1 3 3 3 0 NACHT domain TAFII55_N PF04658.13 EDO06524.1 - 9.1e-27 93.7 0.1 2.2e-26 92.5 0.1 1.6 1 0 0 1 1 1 1 TAFII55 protein conserved region tRNA-synt_1 PF00133.22 EDO06527.1 - 1.9e-94 317.1 0.0 2.8e-94 316.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EDO06527.1 - 1.2e-14 54.0 2.6 2.2e-05 23.4 0.0 4.2 3 1 1 4 4 4 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EDO06527.1 - 1.4e-13 51.1 0.1 3.8e-13 49.7 0.1 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA zf-FPG_IleRS PF06827.14 EDO06527.1 - 0.13 12.1 8.4 0.024 14.5 4.1 2.0 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS MPC PF03650.13 EDO06528.1 - 4.9e-33 113.6 0.1 5.4e-33 113.4 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers U1snRNP70_N PF12220.8 EDO06530.1 - 2.3e-19 69.8 1.9 3.7e-19 69.2 1.9 1.4 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 EDO06530.1 - 2.5e-18 65.7 0.0 4.3e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDO06530.1 - 0.0025 17.4 0.0 0.004 16.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO06530.1 - 0.011 15.8 0.0 0.029 14.5 0.0 1.7 1 1 0 1 1 1 0 RNA recognition motif RRM_8 PF11835.8 EDO06530.1 - 0.046 13.9 0.0 0.087 13.0 0.0 1.5 1 0 0 1 1 1 0 RRM-like domain NAD_binding_1 PF00175.21 EDO06531.1 - 3.6e-11 43.7 0.0 1e-10 42.2 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EDO06531.1 - 6.4e-06 26.4 0.0 0.0015 18.9 0.0 3.0 2 1 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EDO06531.1 - 0.02 15.1 0.3 0.67 10.1 0.1 2.4 1 1 0 2 2 2 0 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 EDO06531.1 - 0.066 13.4 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain DUF2709 PF10915.8 EDO06531.1 - 0.079 12.2 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2709) S_2TMBeta PF18153.1 EDO06531.1 - 0.083 12.7 0.1 0.13 12.1 0.1 1.2 1 0 0 1 1 1 0 SMODS-associating 2TM, beta-strand rich effector domain Sec5 PF15469.6 EDO06531.1 - 0.15 11.9 0.2 0.9 9.3 0.0 2.0 2 0 0 2 2 2 0 Exocyst complex component Sec5 DUF5395 PF17373.2 EDO06532.1 - 0.17 12.6 0.8 3.6 8.3 0.1 2.7 1 1 1 2 2 2 0 Family of unknown function (DUF5395) Ribosomal_L37 PF08561.10 EDO06532.1 - 2 9.0 9.9 22 5.6 0.1 2.1 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L37 RRM_1 PF00076.22 EDO06533.1 - 7.2e-17 61.0 0.0 1.1e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDO06533.1 - 1.1e-05 25.0 0.0 1.3e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDO06533.1 - 0.14 12.0 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif Sel1 PF08238.12 EDO06534.1 - 8.1e-13 48.6 14.7 0.00088 19.9 0.2 6.7 7 0 0 7 7 7 4 Sel1 repeat 5_3_exonuc_N PF02739.16 EDO06535.1 - 5.4e-24 84.9 0.0 2.4e-18 66.6 0.0 2.3 2 0 0 2 2 2 2 5'-3' exonuclease, N-terminal resolvase-like domain 5_3_exonuc PF01367.20 EDO06535.1 - 1e-18 67.7 0.0 2.1e-18 66.7 0.0 1.5 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold RBD PF02196.15 EDO06535.1 - 0.017 15.2 0.1 0.041 14.0 0.1 1.6 1 0 0 1 1 1 0 Raf-like Ras-binding domain HHH_5 PF14520.6 EDO06535.1 - 0.035 14.7 0.0 0.085 13.5 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain U3_assoc_6 PF08640.11 EDO06535.1 - 0.047 13.8 0.1 1.2 9.3 0.1 2.5 2 0 0 2 2 2 0 U3 small nucleolar RNA-associated protein 6 Leptin PF02024.15 EDO06537.1 - 0.068 12.9 0.4 0.16 11.8 0.1 1.6 2 0 0 2 2 2 0 Leptin Peptidase_S29 PF02907.15 EDO06537.1 - 0.15 11.8 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease ATP-synt_D PF01813.17 EDO06539.1 - 0.0011 18.9 0.6 0.0014 18.5 0.6 1.1 1 0 0 1 1 1 1 ATP synthase subunit D MCM PF00493.23 EDO06540.1 - 1.5e-91 305.5 0.0 1.4e-89 299.0 0.0 2.3 1 1 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDO06540.1 - 1.2e-27 96.2 0.1 2.5e-27 95.2 0.1 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EDO06540.1 - 7.5e-18 64.7 0.0 3e-17 62.8 0.0 2.1 2 1 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 EDO06540.1 - 6.4e-09 36.3 0.0 3.1e-08 34.1 0.0 2.2 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EDO06540.1 - 1.3e-08 34.5 0.1 4.2e-06 26.3 0.0 2.8 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDO06540.1 - 1.8e-05 24.7 0.0 5.3e-05 23.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EDO06540.1 - 0.00016 21.4 0.0 0.00087 19.0 0.0 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.11 EDO06540.1 - 0.01 15.7 0.0 0.028 14.3 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 EDO06540.1 - 0.037 14.5 0.0 0.18 12.2 0.0 2.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) SAC3_GANP PF03399.16 EDO06540.1 - 0.075 12.4 0.5 0.16 11.4 0.5 1.4 1 0 0 1 1 1 0 SAC3/GANP family DUF4677 PF15726.5 EDO06540.1 - 0.15 12.3 0.0 0.58 10.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4677) AAA_16 PF13191.6 EDO06540.1 - 0.18 12.2 0.8 0.45 10.9 0.1 2.1 2 0 0 2 2 2 0 AAA ATPase domain CHCH PF06747.13 EDO06541.1 - 8.5e-08 32.1 2.9 5.5e-05 23.2 0.6 2.8 2 1 0 2 2 2 2 CHCH domain CX9C PF16860.5 EDO06541.1 - 2.5e-05 24.2 4.5 0.0014 18.6 0.3 3.0 2 1 1 3 3 3 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, NDUF_B7 PF05676.13 EDO06541.1 - 0.2 11.4 3.2 17 5.2 0.6 2.9 1 1 2 3 3 3 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.10 EDO06541.1 - 0.7 10.0 6.9 1.4 9.0 1.2 2.9 1 1 2 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like UFD1 PF03152.14 EDO06542.1 - 2e-73 245.5 0.0 2.3e-73 245.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 CDC48_2 PF02933.17 EDO06542.1 - 0.042 13.6 0.0 0.089 12.6 0.0 1.5 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), domain 2 Fanconi_A PF03511.14 EDO06542.1 - 0.19 11.7 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 Fanconi anaemia group A protein Rhomboid PF01694.22 EDO06543.1 - 1.3e-24 86.9 8.7 1.3e-24 86.9 8.7 1.7 2 0 0 2 2 2 1 Rhomboid family Rhomboid PF01694.22 EDO06544.1 - 2.2e-24 86.2 10.1 2.2e-24 86.2 10.1 1.9 2 0 0 2 2 2 1 Rhomboid family DUF3938 PF13074.6 EDO06544.1 - 0.14 12.4 0.6 0.45 10.8 0.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3938) Spt5_N PF11942.8 EDO06544.1 - 2.7 9.0 4.7 0.73 10.9 1.1 1.8 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Rhomboid PF01694.22 EDO06545.1 - 2.1e-24 86.2 10.1 2.1e-24 86.2 10.1 2.1 2 0 0 2 2 2 1 Rhomboid family DUF3938 PF13074.6 EDO06545.1 - 0.12 12.6 0.7 0.44 10.8 0.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3938) Spt5_N PF11942.8 EDO06545.1 - 2.6 9.1 4.7 0.71 10.9 1.1 1.8 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Proteasome PF00227.26 EDO06547.1 - 1.6e-37 128.9 0.2 7.3e-21 74.5 0.0 2.1 2 0 0 2 2 2 2 Proteasome subunit Ras PF00071.22 EDO06548.1 - 1e-50 171.5 0.0 1.3e-50 171.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO06548.1 - 9.6e-31 106.5 0.0 1.5e-30 105.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO06548.1 - 7.4e-14 51.6 0.0 9.5e-14 51.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDO06548.1 - 3.5e-06 26.7 0.0 9.2e-06 25.3 0.0 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EDO06548.1 - 0.00011 21.7 0.0 0.00014 21.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDO06548.1 - 0.00061 19.8 0.0 0.0009 19.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDO06548.1 - 0.022 14.7 0.1 1.7 8.5 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase DAP3 PF10236.9 EDO06548.1 - 0.14 11.3 0.0 0.51 9.5 0.0 1.8 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 UDG PF03167.19 EDO06548.1 - 0.16 11.9 0.0 0.35 10.8 0.0 1.4 1 1 0 1 1 1 0 Uracil DNA glycosylase superfamily Methyltr_RsmB-F PF01189.17 EDO06549.1 - 2e-63 213.7 0.0 3.1e-63 213.0 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 EDO06549.1 - 4.3e-10 39.9 0.0 9.4e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 EDO06549.1 - 0.00054 20.1 0.1 0.00098 19.3 0.1 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Fibrillarin PF01269.17 EDO06549.1 - 0.0078 15.3 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 Fibrillarin PCMT PF01135.19 EDO06549.1 - 0.023 14.4 0.0 0.038 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Met_10 PF02475.16 EDO06549.1 - 0.067 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Profilin PF00235.19 EDO06550.1 - 1.2e-16 61.1 0.1 1.9e-16 60.5 0.1 1.3 1 1 0 1 1 1 1 Profilin DUF21 PF01595.20 EDO06551.1 - 2.4e-34 118.5 3.9 3.3e-34 118.1 3.9 1.1 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 EDO06551.1 - 5.5e-06 26.7 4.1 0.0029 18.0 0.6 2.5 2 0 0 2 2 2 2 CBS domain Sulfate_transp PF00916.20 EDO06553.1 - 8.5e-26 90.6 26.8 8.5e-26 90.6 26.8 3.7 2 1 0 3 3 3 1 Sulfate permease family Herpes_U55 PF06501.11 EDO06553.1 - 0.00013 20.9 0.0 0.00022 20.2 0.0 1.2 1 0 0 1 1 1 1 Human herpesvirus U55 protein STAS PF01740.21 EDO06553.1 - 0.004 16.8 0.0 0.0077 15.9 0.0 1.4 1 0 0 1 1 1 1 STAS domain Nop PF01798.18 EDO06554.1 - 1.7e-75 253.4 0.0 2.6e-75 252.8 0.0 1.3 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EDO06554.1 - 3.3e-17 62.6 0.2 7.5e-17 61.5 0.2 1.7 1 0 0 1 1 1 1 NOP5NT (NUC127) domain SIP1 PF04938.12 EDO06555.1 - 4.7e-10 39.6 0.4 9.1e-10 38.6 0.4 1.5 1 1 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) Rep-A_N PF04057.12 EDO06555.1 - 0.061 13.4 0.1 9.9 6.2 0.0 2.3 2 0 0 2 2 2 0 Replication factor-A protein 1, N-terminal domain DBR1 PF05011.13 EDO06556.1 - 8.2e-11 42.5 0.0 1.4e-10 41.7 0.0 1.4 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 EDO06556.1 - 3.5e-08 34.2 1.8 5.2e-08 33.6 1.8 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Rhomboid PF01694.22 EDO06557.1 - 4.4e-14 52.7 12.5 4.4e-14 52.7 12.5 1.7 2 0 0 2 2 2 1 Rhomboid family DUF515 PF04415.12 EDO06557.1 - 0.25 9.7 0.1 0.35 9.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Peptidase_S8 PF00082.22 EDO06558.1 - 2.7e-24 86.0 0.1 2.7e-24 86.0 0.1 1.8 2 0 0 2 2 2 1 Subtilase family SUB1_ProdP9 PF18213.1 EDO06558.1 - 0.029 14.2 2.7 0.047 13.5 0.1 2.6 3 0 0 3 3 3 0 SUB1 protease Prodomain ProdP9 RloB PF13707.6 EDO06558.1 - 0.59 10.3 4.3 0.21 11.7 0.8 2.1 2 1 1 3 3 3 0 RloB-like protein NPL4 PF05021.15 EDO06559.1 - 1.8e-33 116.2 0.0 6.2e-32 111.2 0.0 2.2 1 1 0 1 1 1 1 NPL4 family UN_NPL4 PF11543.8 EDO06559.1 - 6e-11 42.7 0.1 1.5e-10 41.4 0.0 1.7 2 0 0 2 2 2 1 Nuclear pore localisation protein NPL4 zf-NPL4 PF05020.15 EDO06559.1 - 1e-05 25.7 0.1 2.3e-05 24.6 0.1 1.5 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region Rad60-SLD PF11976.8 EDO06559.1 - 0.11 12.3 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Rhomboid PF01694.22 EDO06560.1 - 3.1e-14 53.2 7.5 3.1e-14 53.2 7.5 1.6 2 0 0 2 2 2 1 Rhomboid family DUF1780 PF08682.10 EDO06560.1 - 0.063 13.0 0.0 0.088 12.5 0.0 1.1 1 0 0 1 1 1 0 Putative endonuclease, protein of unknown function (DUF1780) Ribosomal_L4 PF00573.22 EDO06561.1 - 3.6e-42 144.2 0.7 3.6e-42 144.2 0.7 1.5 2 0 0 2 2 2 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 EDO06561.1 - 2.3e-05 24.4 0.6 8.1e-05 22.6 0.5 2.0 1 1 0 1 1 1 1 60S ribosomal protein L4 C-terminal domain MORN PF02493.20 EDO06562.1 - 0.00059 19.6 17.9 0.0034 17.2 2.1 4.0 4 0 0 4 4 4 2 MORN repeat DUF4253 PF14062.6 EDO06563.1 - 0.071 13.3 0.7 1.6 8.9 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4253) MINDY_DUB PF04424.13 EDO06563.1 - 0.18 11.9 2.4 1.8 8.6 0.0 3.3 3 0 0 3 3 3 0 MINDY deubiquitinase Guanylate_kin PF00625.21 EDO06566.1 - 7.7e-42 143.0 0.0 8.8e-42 142.8 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_22 PF13401.6 EDO06566.1 - 1.1e-05 25.7 0.0 2.2e-05 24.7 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EDO06566.1 - 6e-05 23.2 0.0 0.0018 18.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EDO06566.1 - 0.0002 21.9 0.3 0.0015 19.1 0.3 2.0 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EDO06566.1 - 0.00036 21.0 0.0 0.0011 19.4 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 EDO06566.1 - 0.00057 20.4 0.0 0.00084 19.9 0.0 1.4 1 1 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 EDO06566.1 - 0.00058 20.3 0.0 0.0016 18.9 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EDO06566.1 - 0.0017 18.3 0.0 0.0034 17.3 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 EDO06566.1 - 0.0027 17.8 0.0 0.005 16.9 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase dNK PF01712.19 EDO06566.1 - 0.0054 16.6 0.1 0.78 9.6 0.0 2.2 2 0 0 2 2 2 1 Deoxynucleoside kinase RNA_helicase PF00910.22 EDO06566.1 - 0.0093 16.3 0.0 0.014 15.8 0.0 1.4 1 1 0 1 1 1 1 RNA helicase NB-ARC PF00931.22 EDO06566.1 - 0.0096 15.1 0.1 0.012 14.8 0.1 1.6 1 1 0 1 1 1 1 NB-ARC domain AAA_24 PF13479.6 EDO06566.1 - 0.016 14.9 0.1 0.017 14.8 0.1 1.5 1 1 0 1 1 1 0 AAA domain Roc PF08477.13 EDO06566.1 - 0.021 15.0 0.0 0.038 14.2 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_14 PF13173.6 EDO06566.1 - 0.023 14.7 0.0 0.041 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EDO06566.1 - 0.03 14.3 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain ATPase_2 PF01637.18 EDO06566.1 - 0.033 14.1 0.5 0.047 13.6 0.5 1.6 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea MobB PF03205.14 EDO06566.1 - 0.049 13.5 0.0 0.086 12.7 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_23 PF13476.6 EDO06566.1 - 0.05 14.1 0.7 0.11 12.9 0.7 1.9 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EDO06566.1 - 0.053 13.8 0.2 0.32 11.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EDO06566.1 - 0.059 13.3 0.0 0.17 11.8 0.0 1.9 2 0 0 2 2 2 0 NTPase AAA_5 PF07728.14 EDO06566.1 - 0.069 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) SRPRB PF09439.10 EDO06566.1 - 0.094 12.1 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 EDO06566.1 - 0.096 12.2 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region cobW PF02492.19 EDO06566.1 - 0.12 12.0 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EDO06566.1 - 0.13 12.1 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_21 PF13304.6 EDO06566.1 - 0.16 11.7 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EDO06566.1 - 0.19 11.5 0.0 0.52 10.1 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain PFK PF00365.20 EDO06567.1 - 8.7e-57 192.6 0.0 1e-35 123.5 0.0 3.3 3 1 0 3 3 3 2 Phosphofructokinase zf-C3HC PF07967.13 EDO06568.1 - 0.012 15.7 0.0 0.038 14.0 0.0 1.8 2 0 0 2 2 2 0 C3HC zinc finger-like Pro_isomerase PF00160.21 EDO06569.1 - 3.3e-52 176.9 0.1 5.2e-52 176.3 0.1 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-Nse PF11789.8 EDO06569.1 - 2.7e-07 30.3 0.1 6.4e-06 25.9 0.2 2.8 1 1 1 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit Rtf2 PF04641.12 EDO06569.1 - 1.7e-06 27.6 0.8 0.00072 19.0 0.0 3.3 2 1 0 2 2 2 1 Rtf2 RING-finger U-box PF04564.15 EDO06569.1 - 3.9e-06 26.9 0.1 4e-05 23.7 0.0 2.7 3 0 0 3 3 3 1 U-box domain zf-NOSIP PF15906.5 EDO06569.1 - 0.0001 22.4 0.1 0.00055 20.0 0.0 2.2 2 0 0 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein KOW PF00467.29 EDO06570.1 - 0.0035 17.2 0.0 0.0062 16.4 0.0 1.4 1 0 0 1 1 1 1 KOW motif YpzI PF14140.6 EDO06571.1 - 0.0011 18.6 9.3 25 4.7 0.2 6.2 1 1 5 6 6 6 3 YpzI-like protein Asparaginase PF00710.20 EDO06571.1 - 0.043 13.4 0.5 0.23 11.0 0.0 2.4 2 0 0 2 2 2 0 Asparaginase, N-terminal XPB_DRD PF18458.1 EDO06571.1 - 0.17 11.8 0.0 19 5.2 0.0 2.4 2 0 0 2 2 2 0 Xeroderma pigmentosum group B helicase damage recognition domain ddrB-ParB PF18763.1 EDO06571.1 - 9.4 6.4 11.9 2.2 8.4 3.2 2.9 3 0 0 3 3 3 0 ddrB-like ParB superfamily domain SP24 PF16504.5 EDO06572.1 - 0.048 13.7 0.5 0.23 11.5 0.1 2.2 2 0 0 2 2 2 0 Putative virion membrane protein of plant and insect virus Med15_fungi PF05397.12 EDO06572.1 - 1.4 9.3 7.8 0.15 12.3 0.5 3.0 3 1 1 4 4 4 0 Mediator complex subunit 15 CK_II_beta PF01214.18 EDO06573.1 - 7.5e-63 211.6 0.1 1.1e-62 211.1 0.1 1.2 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Ribosomal_L33 PF00471.20 EDO06573.1 - 0.089 13.3 0.7 0.2 12.1 0.7 1.5 1 0 0 1 1 1 0 Ribosomal protein L33 Tmemb_55A PF09788.9 EDO06573.1 - 0.12 11.4 0.2 0.17 10.9 0.2 1.2 1 0 0 1 1 1 0 Transmembrane protein 55A Couple_hipA PF13657.6 EDO06574.1 - 0.011 16.4 0.0 0.018 15.7 0.0 1.3 1 0 0 1 1 1 0 HipA N-terminal domain PseudoU_synth_2 PF00849.22 EDO06575.1 - 0.0068 16.5 0.3 0.017 15.2 0.3 1.7 1 1 0 1 1 1 1 RNA pseudouridylate synthase Hom_end PF05204.14 EDO06575.1 - 1.4 9.1 5.7 1.7 8.9 0.9 2.7 2 1 1 3 3 3 0 Homing endonuclease LAGLIDADG_1 PF00961.19 EDO06575.1 - 3.3 8.7 10.5 0.47 11.5 3.1 2.3 2 0 0 2 2 2 0 LAGLIDADG endonuclease RNase_H2_suC PF08615.11 EDO06576.1 - 1.5e-16 60.8 0.0 2.1e-16 60.4 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) PIP49_C PF12260.8 EDO06577.1 - 0.01 15.5 1.0 0.01 15.5 1.0 2.2 2 1 0 2 2 2 0 Protein-kinase domain of FAM69 Nuc_rec_co-act PF08815.10 EDO06577.1 - 0.12 12.2 0.1 0.35 10.8 0.1 1.8 1 0 0 1 1 1 0 Nuclear receptor coactivator TLD PF07534.16 EDO06578.1 - 3.8e-32 111.4 1.4 5.7e-32 110.8 1.4 1.3 1 0 0 1 1 1 1 TLD GRAM PF02893.20 EDO06578.1 - 0.12 12.3 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 GRAM domain PPP4R2 PF09184.11 EDO06580.1 - 2e-06 27.7 0.0 2.5e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 PPP4R2 RAP PF08373.10 EDO06581.1 - 0.0048 17.0 0.0 0.035 14.2 0.0 2.3 2 0 0 2 2 2 1 RAP domain DUF4791 PF16039.5 EDO06581.1 - 0.013 15.1 0.1 0.028 14.0 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4791) TEP1_N PF05386.11 EDO06581.1 - 3.4 7.3 8.8 1.3 8.7 0.5 3.4 3 0 0 3 3 3 0 TEP1 N-terminal domain Nop PF01798.18 EDO06582.1 - 3.7e-63 213.1 0.3 5.4e-63 212.5 0.3 1.2 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 EDO06582.1 - 4.8e-36 124.3 1.3 6e-35 120.8 1.8 2.2 2 0 0 2 2 2 1 Prp31 C terminal domain MogR_DNAbind PF12181.8 EDO06582.1 - 0.0085 16.0 0.1 0.02 14.8 0.1 1.6 1 0 0 1 1 1 1 DNA binding domain of the motility gene repressor (MogR) ubiquitin PF00240.23 EDO06583.1 - 1.2e-07 31.4 0.0 1.3e-06 28.1 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.6 EDO06583.1 - 0.11 12.6 0.0 0.15 12.2 0.0 1.3 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Pro_isomerase PF00160.21 EDO06584.1 - 8.4e-41 139.9 0.0 1.2e-40 139.4 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD LRR_8 PF13855.6 EDO06585.1 - 2.2e-09 36.9 18.5 0.00019 21.1 1.1 4.8 4 1 0 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 EDO06585.1 - 4.4e-07 30.1 27.4 0.0046 17.3 0.8 7.1 5 2 2 7 7 7 5 Leucine Rich repeats (2 copies) CAP_GLY PF01302.25 EDO06585.1 - 5.2e-06 26.4 0.0 1.1e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 CAP-Gly domain LRR_9 PF14580.6 EDO06585.1 - 0.013 15.0 4.5 0.26 10.8 0.5 3.1 1 1 1 3 3 3 0 Leucine-rich repeat PCNA_N PF00705.18 EDO06586.1 - 1.1e-27 96.2 0.5 2e-27 95.4 0.2 1.6 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 EDO06586.1 - 4e-21 75.5 0.2 5.5e-20 71.8 0.1 2.2 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 EDO06586.1 - 4.1e-08 33.0 0.0 4.9e-07 29.5 0.0 2.1 1 1 0 1 1 1 1 Rad9 Rad1 PF02144.16 EDO06586.1 - 0.00058 19.0 0.2 0.17 10.9 0.0 2.5 1 1 2 3 3 3 2 Repair protein Rad1/Rec1/Rad17 Thioredoxin PF00085.20 EDO06588.1 - 2.4e-26 91.7 0.0 4.1e-26 91.0 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.6 EDO06588.1 - 0.00025 21.0 0.0 0.00033 20.6 0.0 1.3 1 0 0 1 1 1 1 F plasmid transfer operon protein OST3_OST6 PF04756.13 EDO06588.1 - 0.00029 20.3 0.0 0.0007 19.0 0.0 1.8 1 1 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EDO06588.1 - 0.00029 21.1 0.0 0.39 11.1 0.0 2.7 1 1 2 3 3 3 2 Thioredoxin-like Thioredoxin_6 PF13848.6 EDO06588.1 - 0.00061 19.7 0.0 0.0011 18.9 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 EDO06588.1 - 0.0025 17.7 0.0 0.0069 16.3 0.0 1.9 1 1 1 2 2 2 1 AhpC/TSA family Thioredoxin_2 PF13098.6 EDO06588.1 - 0.0049 17.3 0.1 0.04 14.4 0.1 2.2 1 1 0 1 1 1 1 Thioredoxin-like domain Redoxin PF08534.10 EDO06588.1 - 0.014 15.1 0.1 0.021 14.5 0.1 1.3 1 0 0 1 1 1 0 Redoxin Mobilization_B PF17511.2 EDO06588.1 - 0.09 13.1 0.3 0.18 12.2 0.1 1.7 2 0 0 2 2 2 0 Mobilization protein B Thioredoxin_3 PF13192.6 EDO06588.1 - 0.11 12.6 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin domain MMR_HSR1 PF01926.23 EDO06589.1 - 8.7e-10 38.7 0.0 2.2e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDO06589.1 - 0.0014 18.5 0.0 0.003 17.5 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase Arf PF00025.21 EDO06589.1 - 0.018 14.5 0.0 4.7 6.6 0.0 2.2 1 1 1 2 2 2 0 ADP-ribosylation factor family T2SSE PF00437.20 EDO06589.1 - 0.026 13.6 0.0 0.075 12.1 0.0 1.5 1 1 1 2 2 2 0 Type II/IV secretion system protein Dynamin_N PF00350.23 EDO06589.1 - 0.071 13.2 0.3 0.39 10.8 0.1 2.1 2 0 0 2 2 2 0 Dynamin family AAA_7 PF12775.7 EDO06589.1 - 0.089 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_29 PF13555.6 EDO06589.1 - 0.14 11.9 0.0 0.33 10.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 EDO06589.1 - 0.24 11.7 0.1 0.74 10.0 0.0 1.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase IIGP PF05049.13 EDO06589.1 - 0.24 10.4 0.0 0.5 9.4 0.0 1.5 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) PRCC PF10253.9 EDO06590.1 - 2.2e-21 77.6 4.5 2.4e-21 77.5 4.0 1.3 1 1 0 1 1 1 1 Mitotic checkpoint regulator, MAD2B-interacting Mito_carr PF00153.27 EDO06592.1 - 2.5e-51 171.6 0.3 1.5e-17 63.3 0.0 3.3 2 1 1 3 3 3 3 Mitochondrial carrier protein 14-3-3 PF00244.20 EDO06593.1 - 6e-98 326.8 9.0 6.9e-98 326.6 9.0 1.0 1 0 0 1 1 1 1 14-3-3 protein DUF4518 PF15008.6 EDO06593.1 - 0.016 14.4 0.2 0.03 13.5 0.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4518) DUF3617 PF12276.8 EDO06593.1 - 0.066 13.5 1.6 1.5 9.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3617) Acyl-CoA_dh_C PF12806.7 EDO06593.1 - 0.18 12.0 2.3 0.11 12.7 0.3 1.7 2 0 0 2 2 2 0 Acetyl-CoA dehydrogenase C-terminal like TPR_8 PF13181.6 EDO06593.1 - 4.9 7.6 7.1 5.2 7.5 0.8 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Fcf1 PF04900.12 EDO06594.1 - 8.7e-36 122.3 3.1 1.2e-35 121.8 3.1 1.2 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 EDO06594.1 - 1.3e-12 48.1 0.2 2.3e-12 47.2 0.2 1.4 1 0 0 1 1 1 1 PIN like domain PilI PF10623.9 EDO06594.1 - 0.03 14.5 0.8 0.055 13.6 0.5 1.6 1 1 0 1 1 1 0 Plasmid conjugative transfer protein PilI DUF1917 PF08939.10 EDO06594.1 - 0.2 11.5 0.2 0.34 10.8 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1917) DUF842 PF05811.13 EDO06595.1 - 1.5e-29 102.4 6.1 1.7e-29 102.2 6.1 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF842) DUF2680 PF10925.8 EDO06595.1 - 0.031 14.3 0.0 0.075 13.0 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2680) DUF5332 PF17266.2 EDO06595.1 - 0.13 12.0 10.2 0.13 11.9 5.1 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5332) zf-Tim10_DDP PF02953.15 EDO06595.1 - 9.2 6.0 13.7 1.4 8.6 3.3 2.6 1 1 1 2 2 2 0 Tim10/DDP family zinc finger Histone PF00125.24 EDO06596.1 - 2.1e-18 66.9 0.0 2.8e-18 66.6 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EDO06596.1 - 8.4e-12 44.6 0.2 1.6e-11 43.7 0.2 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 EDO06596.1 - 0.00018 21.7 0.0 0.00025 21.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TRAPP PF04051.16 EDO06597.1 - 9.6e-28 96.7 0.0 1.1e-27 96.6 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component DUF1507 PF07408.11 EDO06597.1 - 0.2 11.6 0.0 0.28 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1507) DEAD PF00270.29 EDO06598.1 - 1.7e-43 148.4 0.0 2.4e-43 148.0 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO06598.1 - 2.4e-27 95.5 0.6 6.2e-27 94.1 0.3 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EDO06598.1 - 0.017 15.4 0.0 0.033 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EDO06598.1 - 0.11 12.9 0.0 0.46 10.9 0.0 2.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) zf-RING_2 PF13639.6 EDO06600.1 - 2.2e-11 43.9 5.5 3.7e-11 43.2 5.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDO06600.1 - 2.5e-09 36.8 4.4 4.2e-09 36.1 4.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EDO06600.1 - 5.2e-09 35.7 1.4 5.2e-09 35.7 1.4 1.8 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.7 EDO06600.1 - 3.9e-08 33.5 6.9 1.5e-07 31.6 6.9 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EDO06600.1 - 1.3e-07 31.3 4.5 2.2e-07 30.6 4.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDO06600.1 - 2.4e-06 27.4 4.7 4e-06 26.7 4.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EDO06600.1 - 1e-05 25.4 1.1 2.3e-05 24.3 0.1 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EDO06600.1 - 0.00022 21.0 3.3 0.00036 20.3 3.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EDO06600.1 - 0.0025 17.8 3.9 0.0067 16.5 3.9 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.7 EDO06600.1 - 0.0064 16.6 6.4 0.013 15.6 6.4 1.5 1 0 0 1 1 1 1 RING-variant domain zinc_ribbon_16 PF17034.5 EDO06600.1 - 0.0094 16.2 1.0 0.0094 16.2 1.0 1.5 1 1 0 1 1 1 1 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 EDO06600.1 - 0.0096 15.5 4.3 0.018 14.7 4.3 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Zf_RING PF16744.5 EDO06600.1 - 0.036 14.2 1.0 0.036 14.2 1.0 1.8 1 1 1 2 2 2 0 KIAA1045 RING finger zf-C3H2C3 PF17122.5 EDO06600.1 - 0.064 13.3 1.7 0.064 13.3 1.7 1.7 2 0 0 2 2 1 0 Zinc-finger zf-Nse PF11789.8 EDO06600.1 - 0.097 12.5 1.4 0.19 11.5 1.4 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-PHD-like PF15446.6 EDO06600.1 - 0.16 11.6 3.3 0.28 10.8 3.3 1.3 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain PHD PF00628.29 EDO06600.1 - 0.17 11.8 4.3 0.33 10.9 4.3 1.5 1 0 0 1 1 1 0 PHD-finger Prok-RING_4 PF14447.6 EDO06600.1 - 0.24 11.3 3.0 0.48 10.3 3.0 1.5 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING-like PF08746.11 EDO06600.1 - 1.7 9.1 5.4 3 8.2 5.4 1.5 1 0 0 1 1 1 0 RING-like domain FANCL_C PF11793.8 EDO06600.1 - 3.5 7.9 6.6 11 6.2 6.6 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain TSP_1 PF00090.19 EDO06601.1 - 4.2e-05 23.7 30.3 0.021 15.0 0.1 5.9 5 0 0 5 5 5 3 Thrombospondin type 1 domain MDM1 PF15501.6 EDO06601.1 - 0.067 12.3 10.5 0.1 11.7 10.5 1.1 1 0 0 1 1 1 0 Nuclear protein MDM1 Pns11_12 PF17464.2 EDO06601.1 - 3.2 7.4 7.4 7.7 6.2 7.4 1.6 1 0 0 1 1 1 0 Non-structural protein 11 and 12 Pox_Ag35 PF03286.14 EDO06601.1 - 4.1 7.1 11.1 8 6.2 11.1 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein BUD22 PF09073.10 EDO06601.1 - 5.8 6.1 17.1 9.7 5.4 17.1 1.2 1 0 0 1 1 1 0 BUD22 FAM176 PF14851.6 EDO06601.1 - 6.7 6.4 15.0 13 5.4 0.0 2.6 2 0 0 2 2 2 0 FAM176 family Nop14 PF04147.12 EDO06601.1 - 9.4 4.3 16.3 14 3.8 16.3 1.1 1 0 0 1 1 1 0 Nop14-like family Sina PF03145.16 EDO06602.1 - 0.0078 16.2 0.1 0.012 15.6 0.1 1.3 1 0 0 1 1 1 1 Seven in absentia protein family DUF2427 PF10348.9 EDO06603.1 - 0.65 9.8 0.1 0.65 9.8 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF2427) TSP_1 PF00090.19 EDO06604.1 - 7.4e-08 32.5 17.6 0.0005 20.2 7.0 4.2 3 0 0 3 3 3 3 Thrombospondin type 1 domain SHIRT PF18655.1 EDO06604.1 - 0.18 12.4 0.1 1 10.0 0.1 2.2 2 0 0 2 2 2 0 SHIRT domain DnaJ_C PF01556.18 EDO06606.1 - 2.8e-44 150.8 0.0 4e-44 150.3 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EDO06606.1 - 3.1e-26 91.3 1.0 5.1e-26 90.6 1.0 1.4 1 0 0 1 1 1 1 DnaJ domain Gp-FAR-1 PF05823.12 EDO06606.1 - 0.075 13.4 0.1 5.7 7.3 0.1 2.3 2 0 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) AHD PF17793.1 EDO06606.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 ANC1 homology domain (AHD) Rick_17kDa_Anti PF05433.15 EDO06607.1 - 0.091 12.6 0.5 0.15 12.0 0.5 1.3 1 0 0 1 1 1 0 Glycine zipper 2TM domain Leu_Phe_trans PF03588.14 EDO06608.1 - 1.5e-25 89.6 0.1 2.3e-25 89.0 0.1 1.2 1 0 0 1 1 1 1 Leucyl/phenylalanyl-tRNA protein transferase Acetyltransf_6 PF13480.7 EDO06608.1 - 0.061 13.5 0.1 0.21 11.7 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain NopRA1 PF16201.5 EDO06609.1 - 1.5e-16 60.6 0.8 8.2e-15 54.9 0.0 3.6 4 0 0 4 4 4 1 Nucleolar pre-ribosomal-associated protein 1 s48_45 PF07422.13 EDO06610.1 - 5.1e-23 81.7 3.4 5.3e-12 46.3 0.0 3.0 4 0 0 4 4 4 2 Sexual stage antigen s48/45 domain Tme5_EGF_like PF09064.10 EDO06610.1 - 0.072 13.0 1.0 0.18 11.7 1.0 1.7 1 0 0 1 1 1 0 Thrombomodulin like fifth domain, EGF-like s48_45 PF07422.13 EDO06611.1 - 2.9e-25 88.9 13.7 1.2e-14 54.8 3.3 2.8 3 0 0 3 3 3 2 Sexual stage antigen s48/45 domain s48_45 PF07422.13 EDO06612.1 - 2.2e-22 79.6 7.5 2.1e-12 47.6 3.6 2.7 3 0 0 3 3 3 2 Sexual stage antigen s48/45 domain s48_45 PF07422.13 EDO06613.1 - 1.7e-24 86.5 1.7 8.6e-12 45.6 0.0 3.2 3 0 0 3 3 3 2 Sexual stage antigen s48/45 domain Tme5_EGF_like PF09064.10 EDO06613.1 - 0.064 13.2 1.1 0.16 11.9 1.1 1.7 1 0 0 1 1 1 0 Thrombomodulin like fifth domain, EGF-like s48_45 PF07422.13 EDO06614.1 - 8.7e-27 93.8 8.6 7.6e-12 45.8 0.3 3.6 3 0 0 3 3 3 3 Sexual stage antigen s48/45 domain KH_8 PF17903.1 EDO06615.1 - 3.4e-33 113.6 1.6 4.7e-33 113.1 0.0 2.1 3 0 0 3 3 3 1 Krr1 KH1 domain KH_1 PF00013.29 EDO06615.1 - 0.00014 21.6 0.6 0.00033 20.4 0.6 1.6 1 0 0 1 1 1 1 KH domain Syntaxin PF00804.25 EDO06616.1 - 0.0055 16.4 7.3 0.12 12.1 0.1 3.2 1 1 1 3 3 3 1 Syntaxin DUF3375 PF11855.8 EDO06616.1 - 0.0067 15.4 1.0 0.0086 15.0 0.5 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3375) Spore_III_AF PF09581.10 EDO06616.1 - 0.026 14.6 2.0 0.032 14.3 2.0 1.2 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) RNA_pol PF00940.19 EDO06616.1 - 0.05 12.4 0.4 0.057 12.3 0.4 1.2 1 1 0 1 1 1 0 DNA-dependent RNA polymerase TMF_TATA_bd PF12325.8 EDO06616.1 - 0.053 13.7 0.5 4.1 7.7 0.0 2.9 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding MscS_porin PF12795.7 EDO06616.1 - 0.2 11.2 6.4 0.27 10.8 6.4 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain CHDCT2 PF08074.11 EDO06616.1 - 0.33 11.1 3.3 9.9 6.3 1.1 2.9 1 1 1 2 2 2 0 CHDCT2 (NUC038) domain Effector_1 PF04518.12 EDO06616.1 - 1.2 8.2 6.0 3.7 6.6 5.1 2.2 1 1 1 2 2 2 0 Effector from type III secretion system Ribosomal_L22 PF00237.19 EDO06617.1 - 1.3e-12 47.9 0.0 2.3e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Na_H_Exchanger PF00999.21 EDO06618.1 - 1.7e-08 33.7 9.4 2.6e-08 33.1 9.4 1.3 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family MgtE PF01769.16 EDO06618.1 - 0.12 12.7 5.6 0.96 9.8 0.1 2.1 2 0 0 2 2 2 0 Divalent cation transporter DUF368 PF04018.13 EDO06618.1 - 0.21 11.2 6.8 0.81 9.2 6.8 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF368) SF3A2 PF16835.5 EDO06621.1 - 1.4e-32 111.9 0.0 2e-32 111.4 0.0 1.2 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 EDO06621.1 - 1.3e-05 25.4 0.4 1.3e-05 25.4 0.4 1.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.9 EDO06621.1 - 0.00089 19.2 0.1 0.0013 18.6 0.1 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein DnaJ PF00226.31 EDO06622.1 - 1.8e-18 66.4 0.3 1.6e-17 63.3 0.2 2.5 1 1 1 2 2 2 1 DnaJ domain Thioredoxin PF00085.20 EDO06622.1 - 9.3e-06 25.6 0.0 1.9e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin NTP_transferase PF00483.23 EDO06623.1 - 2.3e-49 168.2 0.0 2.8e-49 167.9 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EDO06623.1 - 1.3e-11 43.7 12.3 7.8e-06 25.4 3.6 4.7 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EDO06623.1 - 3.8e-09 37.1 0.0 4.9e-09 36.7 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 EDO06623.1 - 0.00047 19.8 10.4 0.031 14.0 5.1 3.8 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase DUF1694 PF07997.11 EDO06623.1 - 0.13 12.4 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1694) CTP_transf_3 PF02348.19 EDO06623.1 - 0.19 11.6 0.1 0.35 10.8 0.1 1.3 1 0 0 1 1 1 0 Cytidylyltransferase UQ_con PF00179.26 EDO06624.1 - 4.2e-25 88.0 0.0 5.3e-25 87.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDO06624.1 - 3.4e-05 23.6 0.0 0.00024 20.8 0.0 1.9 2 0 0 2 2 2 1 Prokaryotic E2 family B UEV PF05743.13 EDO06624.1 - 0.018 14.9 0.0 0.025 14.4 0.0 1.4 1 0 0 1 1 1 0 UEV domain UFC1 PF08694.11 EDO06624.1 - 0.11 12.1 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.22 EDO06624.1 - 0.13 12.6 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 RWD domain MACPF PF01823.19 EDO06625.1 - 7.1e-13 49.1 0.1 7.1e-13 49.1 0.1 3.2 2 1 1 3 3 3 1 MAC/Perforin domain Adap_comp_sub PF00928.21 EDO06626.1 - 1.7e-53 181.7 0.0 2.1e-53 181.4 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EDO06626.1 - 0.0029 17.5 0.1 0.0051 16.8 0.1 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain VESA1_N PF12785.7 EDO06628.1 - 3.2e-218 725.3 18.0 3.2e-218 725.3 18.0 2.9 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 Baculo_PEP_C PF04513.12 EDO06628.1 - 6.5 6.8 7.9 3.5 7.7 1.3 3.2 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus VESA1_N PF12785.7 EDO06629.1 - 2.7e-21 76.1 10.5 2.7e-21 76.1 10.5 5.4 5 1 1 6 6 6 2 Variant erythrocyte surface antigen-1 DUF5638 PF18688.1 EDO06629.1 - 0.18 12.1 0.1 0.37 11.1 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5638) DUF2510 PF10708.9 EDO06629.1 - 1 9.2 3.4 0.54 10.1 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2510) F-box-like_2 PF13013.6 EDO06630.1 - 7.2e-05 22.7 0.1 0.00011 22.1 0.1 1.3 1 0 0 1 1 1 1 F-box-like domain F-box-like_2 PF13013.6 EDO06631.1 - 1.6e-13 50.6 3.6 2.8e-06 27.3 0.2 2.9 1 1 2 3 3 3 3 F-box-like domain Band_7 PF01145.25 EDO06631.1 - 0.026 14.6 0.0 0.96 9.4 0.0 2.2 2 0 0 2 2 2 0 SPFH domain / Band 7 family DUF2076 PF09849.9 EDO06631.1 - 0.084 12.9 0.1 0.13 12.3 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) VESA1_N PF12785.7 EDO06632.1 - 4.2e-19 68.9 15.9 4.7e-10 39.0 0.2 3.2 1 1 2 3 3 3 3 Variant erythrocyte surface antigen-1 DUF5638 PF18688.1 EDO06632.1 - 0.1 12.9 0.1 0.23 11.8 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5638) VESA1_N PF12785.7 EDO06633.1 - 1.3e-218 726.5 20.2 1.3e-218 726.5 20.2 3.3 4 0 0 4 4 4 1 Variant erythrocyte surface antigen-1 DDE_Tnp_1_assoc PF13808.6 EDO06633.1 - 0.16 12.0 0.0 3.3 7.8 0.0 3.1 3 0 0 3 3 3 0 DDE_Tnp_1-associated DotU PF09850.9 EDO06633.1 - 0.17 11.6 0.7 12 5.5 0.0 2.9 3 0 0 3 3 3 0 Type VI secretion system protein DotU Birna_RdRp PF04197.12 EDO06633.1 - 0.18 10.0 0.0 0.28 9.5 0.0 1.1 1 0 0 1 1 1 0 Birnavirus RNA dependent RNA polymerase (VP1) RhoGAP PF00620.27 EDO06633.1 - 0.22 11.3 0.3 0.84 9.4 0.1 2.0 2 0 0 2 2 2 0 RhoGAP domain HOOK PF05622.12 EDO06633.1 - 0.87 7.7 11.0 0.69 8.0 2.7 2.2 2 0 0 2 2 2 0 HOOK protein DUF4208 PF13907.6 EDO06633.1 - 2.4 8.6 9.5 0.66 10.4 1.3 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4208) Spc7 PF08317.11 EDO06633.1 - 3.8 6.3 8.7 1.6 7.5 1.8 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein YlbD_coat PF14071.6 EDO06633.1 - 6.9 6.9 7.3 5.3 7.3 0.2 3.3 4 0 0 4 4 4 0 Putative coat protein Hydrolase_4 PF12146.8 EDO06634.1 - 2.2e-25 89.3 0.0 1.1e-24 87.1 0.0 2.0 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDO06634.1 - 2.4e-24 86.4 0.0 1.4e-16 61.0 0.1 2.2 1 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDO06634.1 - 5.8e-11 43.4 0.0 2.2e-10 41.5 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 EDO06634.1 - 3.7e-06 26.6 0.0 0.0026 17.3 0.0 2.5 2 0 0 2 2 2 2 Dienelactone hydrolase family Ndr PF03096.14 EDO06634.1 - 7.7e-06 24.8 0.0 1.2e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Ndr family Abhydrolase_3 PF07859.13 EDO06634.1 - 0.00018 21.4 0.0 0.001 19.0 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold LIDHydrolase PF10230.9 EDO06634.1 - 0.00044 19.9 0.0 0.0013 18.4 0.0 1.8 1 1 1 2 2 2 1 Lipid-droplet associated hydrolase Peptidase_S9 PF00326.21 EDO06634.1 - 0.00048 19.7 0.0 0.12 11.9 0.0 2.5 2 0 0 2 2 2 1 Prolyl oligopeptidase family FSH1 PF03959.13 EDO06634.1 - 0.0011 18.7 0.0 0.0026 17.4 0.0 1.6 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.7 EDO06634.1 - 0.0012 18.7 0.0 0.19 11.4 0.0 3.0 3 0 0 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.10 EDO06634.1 - 0.0015 18.6 0.0 0.0032 17.5 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein Esterase PF00756.20 EDO06634.1 - 0.0054 16.4 0.0 0.0076 15.9 0.0 1.2 1 0 0 1 1 1 1 Putative esterase BAAT_C PF08840.11 EDO06634.1 - 0.008 16.1 0.0 0.027 14.4 0.0 1.9 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S15 PF02129.18 EDO06634.1 - 0.028 14.0 0.0 1.7 8.2 0.0 2.8 2 1 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Palm_thioest PF02089.15 EDO06634.1 - 0.034 14.0 0.0 0.047 13.5 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Chlorophyllase2 PF12740.7 EDO06634.1 - 0.052 12.4 0.0 0.13 11.1 0.0 1.6 2 0 0 2 2 2 0 Chlorophyllase enzyme WD40 PF00400.32 EDO06636.1 - 8e-12 45.5 13.2 0.013 16.3 0.2 5.7 5 0 0 5 5 5 4 WD domain, G-beta repeat WD40_like PF17005.5 EDO06636.1 - 0.026 13.8 0.6 5.6 6.2 0.0 2.4 2 0 0 2 2 2 0 WD40-like domain WD40 PF00400.32 EDO06637.1 - 8.6e-29 99.2 8.0 0.00029 21.6 0.3 8.4 7 0 0 7 7 7 6 WD domain, G-beta repeat Utp13 PF08625.11 EDO06637.1 - 1.5e-23 83.3 0.1 2.6e-23 82.5 0.1 1.4 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 EDO06637.1 - 2.6e-10 40.4 0.4 0.01 16.1 0.0 5.5 4 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EDO06637.1 - 0.005 16.2 6.7 5.5 6.2 0.9 4.8 3 1 1 5 5 5 3 WD40-like domain WD40 PF00400.32 EDO06638.1 - 1e-11 45.2 2.7 0.014 16.3 0.1 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO06638.1 - 1e-05 25.7 0.0 0.47 10.8 0.0 4.3 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EDO06638.1 - 0.026 14.1 0.1 7.7 6.0 0.0 3.4 1 1 2 3 3 3 0 PQQ-like domain WD40_like PF17005.5 EDO06638.1 - 0.062 12.6 0.0 0.091 12.1 0.0 1.2 1 0 0 1 1 1 0 WD40-like domain PQQ_3 PF13570.6 EDO06638.1 - 1.1 9.9 5.2 9.2 6.9 0.0 4.4 6 1 0 6 6 6 0 PQQ-like domain Pkinase PF00069.25 EDO06639.1 - 2.4e-52 177.9 0.0 2.5e-41 141.8 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO06639.1 - 1.4e-27 96.6 0.0 3.4e-22 79.0 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase FTA2 PF13095.6 EDO06639.1 - 4.5e-05 23.2 0.1 0.09 12.4 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EDO06639.1 - 0.0012 17.7 0.0 0.0022 16.8 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EDO06639.1 - 0.035 14.0 0.0 0.064 13.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DoxA PF07680.11 EDO06639.1 - 0.056 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 TQO small subunit DoxA Kdo PF06293.14 EDO06639.1 - 0.069 12.5 0.1 0.13 11.6 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Flavoprotein PF02441.19 EDO06640.1 - 4.6e-49 166.2 0.0 5.2e-49 166.0 0.0 1.0 1 0 0 1 1 1 1 Flavoprotein Lactamase_B_5 PF14597.6 EDO06640.1 - 0.17 11.4 0.0 0.27 10.7 0.0 1.2 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Snf7 PF03357.21 EDO06641.1 - 2.5e-16 59.8 9.4 3.1e-16 59.5 9.4 1.1 1 0 0 1 1 1 1 Snf7 Peptidase_S46 PF10459.9 EDO06641.1 - 0.0041 15.8 3.8 0.0052 15.5 3.8 1.1 1 0 0 1 1 1 1 Peptidase S46 z-alpha PF02295.17 EDO06641.1 - 0.097 12.7 0.7 0.31 11.1 0.6 2.0 1 1 0 1 1 1 0 Adenosine deaminase z-alpha domain HIP1_clath_bdg PF16515.5 EDO06641.1 - 4.9 7.8 13.3 2.9 8.6 7.4 2.3 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Citrate_synt PF00285.21 EDO06642.1 - 1.7e-92 310.3 0.0 2e-92 310.0 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain GcpE PF04551.14 EDO06643.1 - 1.6e-154 514.2 0.1 5.2e-109 364.6 0.0 2.4 3 0 0 3 3 3 2 GcpE protein zf-CDGSH PF09360.10 EDO06644.1 - 1.3e-17 63.7 5.3 1.9e-10 40.8 0.3 2.2 2 0 0 2 2 2 2 Iron-binding zinc finger CDGSH type GDNF PF02351.16 EDO06644.1 - 0.49 11.4 4.0 1 10.4 0.4 2.1 1 1 1 2 2 2 0 GDNF/GAS1 domain Acyltransferase PF01553.21 EDO06645.1 - 1.1e-13 50.9 0.0 1.7e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase VPS9 PF02204.18 EDO06646.1 - 1.9e-25 89.1 0.0 3.8e-25 88.1 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain HemN_C PF06969.16 EDO06646.1 - 0.0091 16.0 0.1 0.062 13.4 0.0 2.3 3 0 0 3 3 3 1 HemN C-terminal domain DUF5601 PF18151.1 EDO06646.1 - 0.018 15.3 0.0 0.049 13.9 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5601) Peptidase_S58 PF03576.14 EDO06646.1 - 0.17 11.4 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 Peptidase family S58 CAF1C_H4-bd PF12265.8 EDO06647.1 - 6.9e-16 58.3 0.2 2e-15 56.8 0.0 1.9 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EDO06647.1 - 1.1e-11 45.0 17.8 0.0012 19.6 0.5 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO06647.1 - 7.7e-08 32.5 2.3 0.0038 17.5 0.1 4.5 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 EDO06647.1 - 0.009 14.4 0.0 0.014 13.7 0.0 1.3 1 0 0 1 1 1 1 WD repeat-containing and planar cell polarity effector protein Fritz PX PF00787.24 EDO06648.1 - 2.5e-06 27.4 0.0 5.3e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 PX domain WD40 PF00400.32 EDO06648.1 - 0.0035 18.2 0.3 3.2 8.8 0.0 4.4 4 0 0 4 4 4 1 WD domain, G-beta repeat Enterotoxin_a PF01375.17 EDO06648.1 - 0.0055 16.3 0.1 0.011 15.4 0.1 1.4 1 0 0 1 1 1 1 Heat-labile enterotoxin alpha chain MFS_1 PF07690.16 EDO06649.1 - 1.1e-06 27.8 17.9 3.1e-06 26.3 17.9 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 EDO06650.1 - 3.2e-13 49.3 20.9 4.7e-13 48.8 20.9 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily DnaGprimase_HBD PF16730.5 EDO06650.1 - 0.071 13.2 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 DnaG-primase C-terminal, helicase-binding domain GCP_N_terminal PF17681.1 EDO06651.1 - 7.1e-31 108.0 0.1 1.4e-30 107.0 0.1 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EDO06651.1 - 2.4e-22 79.8 0.8 5.5e-22 78.6 0.4 1.7 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal CAF1 PF04857.20 EDO06652.1 - 2.2e-74 250.5 0.1 2.8e-74 250.2 0.1 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease RNA_bind PF08675.11 EDO06652.1 - 0.0008 19.4 0.2 0.002 18.1 0.2 1.7 1 0 0 1 1 1 1 RNA binding domain R3H PF01424.22 EDO06652.1 - 0.011 15.7 0.0 0.024 14.6 0.0 1.6 1 0 0 1 1 1 0 R3H domain DFRP_C PF16543.5 EDO06653.1 - 2.6e-13 50.3 0.3 2.6e-13 50.3 0.3 3.4 2 1 1 3 3 3 1 DRG Family Regulatory Proteins, Tma46 AP1AR PF15745.5 EDO06653.1 - 0.013 15.2 0.1 0.013 15.2 0.1 2.3 2 1 1 3 3 3 0 AP-1 complex-associated regulatory protein DUF2826 PF11442.8 EDO06653.1 - 0.038 13.8 0.3 0.06 13.2 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2826) ARS2 PF04959.13 EDO06653.1 - 4.7 7.5 9.6 10 6.5 2.9 2.6 2 2 0 2 2 2 0 Arsenite-resistance protein 2 eIF-5_eIF-2B PF01873.17 EDO06654.1 - 3.9e-34 117.0 0.1 6.9e-34 116.2 0.1 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 zf-RanBP PF00641.18 EDO06654.1 - 0.36 10.2 2.2 4.3 6.7 0.1 2.3 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others ETRAMP PF09716.10 EDO06655.1 - 1.3 9.1 5.3 1.9 8.6 0.6 2.3 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Ribosomal_L28 PF00830.19 EDO06656.1 - 1.4e-13 50.8 2.3 1.4e-13 50.8 2.3 2.7 3 1 0 3 3 3 1 Ribosomal L28 family GHMP_kinases_C PF08544.13 EDO06657.1 - 0.0017 18.7 0.0 0.0039 17.5 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 EDO06657.1 - 0.016 15.5 0.3 0.016 15.5 0.3 2.1 2 0 0 2 2 2 0 GHMP kinases N terminal domain PPR_2 PF13041.6 EDO06658.1 - 0.004 17.3 0.1 0.022 14.9 0.1 2.1 2 0 0 2 2 2 1 PPR repeat family Cdh1_DBD_1 PF18196.1 EDO06658.1 - 0.052 13.9 1.2 0.13 12.6 1.2 1.7 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 Importin_rep_2 PF18786.1 EDO06658.1 - 0.07 13.0 0.6 0.18 11.7 0.6 1.7 1 0 0 1 1 1 0 Importin 13 repeat Exonuc_VII_L PF02601.15 EDO06658.1 - 0.094 12.3 6.6 0.012 15.3 1.4 1.8 1 1 1 2 2 2 0 Exonuclease VII, large subunit AAA PF00004.29 EDO06659.1 - 8.8e-07 29.4 0.0 3.2e-06 27.6 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDO06659.1 - 8e-06 26.3 0.0 2.8e-05 24.6 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EDO06659.1 - 0.00013 22.3 0.0 0.00028 21.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EDO06659.1 - 0.00053 19.5 0.0 0.00097 18.7 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region NACHT PF05729.12 EDO06659.1 - 0.0044 17.0 0.0 0.0096 15.9 0.0 1.6 1 1 0 1 1 1 1 NACHT domain PIF1 PF05970.14 EDO06659.1 - 0.0052 16.0 0.1 0.014 14.6 0.0 1.6 2 0 0 2 2 2 1 PIF1-like helicase DUF2075 PF09848.9 EDO06659.1 - 0.0081 15.4 0.0 0.01 15.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 EDO06659.1 - 0.0091 16.3 0.0 0.026 14.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EDO06659.1 - 0.073 12.1 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein MeaB PF03308.16 EDO06659.1 - 0.077 12.0 0.2 7.5 5.4 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_24 PF13479.6 EDO06659.1 - 0.11 12.2 0.0 0.22 11.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EDO06659.1 - 0.13 12.2 0.0 0.27 11.1 0.0 1.5 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_18 PF13238.6 EDO06659.1 - 0.14 12.8 1.1 0.29 11.7 0.6 2.0 2 1 0 2 2 1 0 AAA domain CPL PF08144.11 EDO06660.1 - 8.2e-05 23.0 1.3 8.2e-05 23.0 1.3 4.9 4 1 1 5 5 5 1 CPL (NUC119) domain DNA_pol_B_palm PF14792.6 EDO06660.1 - 0.01 16.0 0.9 0.063 13.5 0.1 2.7 3 0 0 3 3 3 0 DNA polymerase beta palm ATP_bind_3 PF01171.20 EDO06660.1 - 4.6 7.0 8.9 0.14 11.9 0.9 2.5 4 0 0 4 4 4 0 PP-loop family MRP-L27 PF09809.9 EDO06661.1 - 6e-11 42.2 0.0 6.9e-11 42.0 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 AP2 PF00847.20 EDO06662.1 - 5.2e-07 29.8 1.9 0.002 18.4 0.3 2.7 2 0 0 2 2 2 2 AP2 domain XRN_N PF03159.18 EDO06664.1 - 7.7e-87 290.7 0.0 1.4e-86 289.8 0.0 1.5 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 EDO06664.1 - 4.9e-48 164.2 10.5 4.1e-20 72.2 0.2 4.5 5 0 0 5 5 5 3 Xrn1 helical domain SH3_12 PF18129.1 EDO06664.1 - 1.7e-20 72.9 0.9 3.1e-20 72.0 0.2 1.9 2 0 0 2 2 2 1 Xrn1 SH3-like domain XRN1_D1 PF18332.1 EDO06664.1 - 4.2e-05 23.4 0.0 0.00027 20.7 0.0 2.2 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D1 domain MACPF PF01823.19 EDO06665.1 - 2.1e-39 135.8 0.4 2.1e-39 135.8 0.4 1.8 2 0 0 2 2 2 1 MAC/Perforin domain tRNA-synt_2d PF01409.20 EDO06667.1 - 6.4e-35 120.8 0.1 3.4e-19 69.3 0.0 3.1 1 1 1 3 3 3 3 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 EDO06667.1 - 9.7e-17 61.2 0.0 3.3e-16 59.5 0.0 1.9 2 0 0 2 2 2 1 Ferredoxin-fold anticodon binding domain tRNA-synt_2 PF00152.20 EDO06667.1 - 0.02 14.0 0.0 1.5 7.8 0.0 2.8 3 0 0 3 3 3 0 tRNA synthetases class II (D, K and N) C2 PF00168.30 EDO06668.1 - 1.7e-13 50.7 0.2 2.1e-11 44.0 0.1 3.8 3 1 0 3 3 3 1 C2 domain DHO_dh PF01180.21 EDO06669.1 - 1.7e-87 293.4 0.4 2e-87 293.1 0.4 1.0 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase NMO PF03060.15 EDO06669.1 - 0.00044 19.7 0.0 0.00079 18.9 0.0 1.4 1 0 0 1 1 1 1 Nitronate monooxygenase TMP-TENI PF02581.17 EDO06669.1 - 0.13 11.6 0.0 2.1 7.6 0.0 2.3 2 0 0 2 2 2 0 Thiamine monophosphate synthase His_biosynth PF00977.21 EDO06669.1 - 0.14 11.6 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein AAA PF00004.29 EDO06670.1 - 4e-53 179.4 0.0 2.6e-38 131.4 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EDO06670.1 - 9.2e-12 45.1 0.0 9.2e-06 25.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDO06670.1 - 1.8e-11 44.5 1.3 0.00047 20.4 0.1 4.2 2 2 2 4 4 3 3 AAA domain AAA_16 PF13191.6 EDO06670.1 - 1.9e-10 41.4 0.7 0.0021 18.5 0.0 3.4 2 1 1 3 3 3 2 AAA ATPase domain CDC48_N PF02359.18 EDO06670.1 - 3.6e-10 39.9 0.0 1e-09 38.4 0.0 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_lid_3 PF17862.1 EDO06670.1 - 9.8e-09 34.9 0.0 2.5e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 EDO06670.1 - 2.8e-08 34.1 0.0 2.4e-06 27.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) ATPase_2 PF01637.18 EDO06670.1 - 9.5e-08 32.2 0.1 0.13 12.1 0.0 4.1 2 2 1 4 4 4 2 ATPase domain predominantly from Archaea AAA_33 PF13671.6 EDO06670.1 - 1.2e-07 32.0 0.0 0.0014 18.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 EDO06670.1 - 1.8e-07 30.7 0.0 0.014 14.6 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_14 PF13173.6 EDO06670.1 - 1.1e-06 28.7 0.0 0.073 13.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EDO06670.1 - 1.2e-06 29.1 0.0 0.0018 18.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 EDO06670.1 - 3e-06 27.2 0.0 0.08 12.9 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 EDO06670.1 - 3.5e-06 27.4 0.0 0.015 15.7 0.0 2.6 2 0 0 2 2 2 2 RNA helicase Mg_chelatase PF01078.21 EDO06670.1 - 3.7e-06 26.5 0.0 0.0061 16.0 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 EDO06670.1 - 7.1e-06 25.8 0.1 0.049 13.4 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 EDO06670.1 - 1.5e-05 25.0 0.9 0.22 11.4 0.0 3.3 2 2 1 3 3 3 2 Rad17 P-loop domain AAA_7 PF12775.7 EDO06670.1 - 2.3e-05 24.0 0.1 0.01 15.4 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region NACHT PF05729.12 EDO06670.1 - 2.8e-05 24.1 0.2 0.36 10.7 0.0 3.2 3 1 0 3 3 2 2 NACHT domain Sigma54_activat PF00158.26 EDO06670.1 - 0.00014 21.7 0.0 0.64 9.7 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_28 PF13521.6 EDO06670.1 - 0.00017 21.9 0.0 0.053 13.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EDO06670.1 - 0.00025 20.8 0.0 0.0084 15.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EDO06670.1 - 0.0003 20.1 0.1 1.5 7.9 0.0 3.2 2 1 0 3 3 3 2 NB-ARC domain AAA_25 PF13481.6 EDO06670.1 - 0.00063 19.4 0.2 0.36 10.4 0.0 2.8 2 1 1 3 3 3 1 AAA domain ABC_tran PF00005.27 EDO06670.1 - 0.00067 20.2 0.1 0.32 11.5 0.0 2.4 2 0 0 2 2 2 1 ABC transporter Parvo_NS1 PF01057.17 EDO06670.1 - 0.00082 18.5 0.0 0.21 10.6 0.0 2.3 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 IstB_IS21 PF01695.17 EDO06670.1 - 0.0011 18.7 0.0 0.41 10.3 0.0 2.6 2 0 0 2 2 2 1 IstB-like ATP binding protein ATPase PF06745.13 EDO06670.1 - 0.0018 17.7 0.0 0.019 14.3 0.0 2.2 2 0 0 2 2 2 1 KaiC TniB PF05621.11 EDO06670.1 - 0.0024 17.3 0.1 2.2 7.6 0.0 3.3 2 1 1 3 3 3 1 Bacterial TniB protein CDC48_2 PF02933.17 EDO06670.1 - 0.0075 16.0 0.1 0.044 13.6 0.0 2.2 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_3 PF07726.11 EDO06670.1 - 0.0079 16.0 0.0 0.066 13.1 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EDO06670.1 - 0.01 15.6 0.0 0.15 11.9 0.0 2.8 2 2 0 2 2 2 0 DNA polymerase III, delta subunit AAA_11 PF13086.6 EDO06670.1 - 0.013 15.3 0.0 0.3 10.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AFG1_ATPase PF03969.16 EDO06670.1 - 0.017 14.0 0.0 1.2 8.0 0.0 2.2 2 0 0 2 2 2 0 AFG1-like ATPase AAA_30 PF13604.6 EDO06670.1 - 0.022 14.4 0.0 0.4 10.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.9 EDO06670.1 - 0.023 13.9 0.1 1 8.4 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 DUF815 PF05673.13 EDO06670.1 - 0.024 13.8 0.0 1.4 8.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) SKI PF01202.22 EDO06670.1 - 0.024 14.7 0.0 2.1 8.5 0.0 2.4 2 0 0 2 2 2 0 Shikimate kinase Zeta_toxin PF06414.12 EDO06670.1 - 0.026 13.8 0.0 4.3 6.6 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin Cytidylate_kin PF02224.18 EDO06670.1 - 0.039 13.7 0.0 11 5.6 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase PhoH PF02562.16 EDO06670.1 - 0.043 13.3 0.0 2.4 7.5 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein DUF2075 PF09848.9 EDO06670.1 - 0.057 12.7 0.1 0.15 11.3 0.0 1.7 2 0 0 2 2 1 0 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 EDO06670.1 - 0.057 13.4 0.0 0.89 9.5 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_29 PF13555.6 EDO06670.1 - 0.074 12.8 0.1 15 5.4 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain Sigma54_activ_2 PF14532.6 EDO06670.1 - 0.1 12.7 0.0 3.9 7.6 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_PrkA PF08298.11 EDO06670.1 - 0.15 11.0 0.0 2.2 7.1 0.0 2.1 2 0 0 2 2 2 0 PrkA AAA domain AAA_17 PF13207.6 EDO06670.1 - 0.22 11.9 3.4 8.3 6.8 0.1 3.4 3 1 1 4 4 3 0 AAA domain CRM1_C PF08767.11 EDO06672.1 - 8e-125 416.3 3.6 8e-125 416.3 3.6 3.4 4 0 0 4 4 4 1 CRM1 C terminal Xpo1 PF08389.12 EDO06672.1 - 4.7e-33 114.3 1.5 4.7e-33 114.3 1.5 3.3 3 0 0 3 3 3 1 Exportin 1-like protein CRM1_repeat_3 PF18787.1 EDO06672.1 - 2.4e-20 72.4 2.1 2e-19 69.4 0.0 3.4 4 0 0 4 4 4 1 CRM1 / Exportin repeat 3 CRM1_repeat_2 PF18784.1 EDO06672.1 - 1.2e-17 63.3 1.0 7e-17 60.8 1.0 2.5 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 IBN_N PF03810.19 EDO06672.1 - 1.2e-09 37.9 0.2 3.4e-09 36.5 0.2 1.9 1 0 0 1 1 1 1 Importin-beta N-terminal domain CRM1_repeat PF18777.1 EDO06672.1 - 1.7e-08 33.8 0.5 5.1e-08 32.3 0.5 1.8 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat MukF_M PF17192.4 EDO06672.1 - 0.067 12.9 0.0 14 5.3 0.0 2.7 2 0 0 2 2 2 0 MukF middle domain Pkinase PF00069.25 EDO06673.1 - 6.9e-50 169.9 0.2 2.5e-49 168.0 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO06673.1 - 5.8e-19 68.4 0.0 1.7e-17 63.6 0.0 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDO06673.1 - 0.052 12.9 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TYW3 PF02676.14 EDO06674.1 - 1.3e-37 129.3 0.0 2e-37 128.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase TYW3 PHF5 PF03660.14 EDO06675.1 - 2.2e-48 162.8 15.0 6.2e-48 161.3 15.0 1.8 1 0 0 1 1 1 1 PHF5-like protein GTP_EFTU PF00009.27 EDO06675.1 - 4e-31 108.1 0.7 5.5e-30 104.4 0.0 2.9 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EDO06675.1 - 1.7e-17 63.4 0.3 4.6e-17 62.1 0.3 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.6 EDO06675.1 - 2e-14 53.2 0.0 6.8e-14 51.5 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 4 GTP_EFTU_D2 PF03144.25 EDO06675.1 - 6.3e-13 48.9 3.0 1e-08 35.4 0.5 3.6 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDO06675.1 - 8.2e-06 25.9 0.5 0.00016 21.8 0.0 3.2 3 0 0 3 3 3 1 50S ribosome-binding GTPase Roc PF08477.13 EDO06675.1 - 0.0005 20.3 0.0 0.0014 18.9 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EDO06675.1 - 0.018 14.8 0.0 0.13 12.0 0.0 2.5 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein SH3_14 PF18343.1 EDO06675.1 - 0.045 13.8 0.2 0.76 9.9 0.2 2.4 2 0 0 2 2 2 0 Dda helicase SH3 domain DUF4225 PF13988.6 EDO06675.1 - 0.12 11.9 0.0 0.41 10.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4225) zf-RING_2 PF13639.6 EDO06676.1 - 3e-11 43.4 7.2 3e-11 43.4 7.2 2.0 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 EDO06676.1 - 7.7e-07 28.8 3.7 7.7e-07 28.8 3.7 2.3 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EDO06676.1 - 1.3e-05 24.9 4.2 1.3e-05 24.9 4.2 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDO06676.1 - 1.4e-05 24.9 3.5 1.4e-05 24.9 3.5 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.7 EDO06676.1 - 2.4e-05 24.5 8.8 0.00011 22.4 8.8 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EDO06676.1 - 2.4e-05 24.1 3.4 2.4e-05 24.1 3.4 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EDO06676.1 - 0.0013 18.3 2.4 0.0013 18.3 2.4 1.8 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type RINGv PF12906.7 EDO06676.1 - 0.0024 18.0 5.4 0.0024 18.0 5.4 1.8 2 0 0 2 2 1 1 RING-variant domain zf-C3HC4 PF00097.25 EDO06676.1 - 0.0055 16.6 4.4 0.0055 16.6 4.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDO06676.1 - 0.0061 16.6 1.8 0.0097 15.9 0.4 2.1 1 1 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EDO06676.1 - 0.0071 16.2 2.9 0.0071 16.2 2.9 2.1 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 FANCL_C PF11793.8 EDO06676.1 - 0.047 13.9 2.6 0.047 13.9 2.6 2.0 2 1 0 2 2 2 0 FANCL C-terminal domain zf-ANAPC11 PF12861.7 EDO06676.1 - 0.052 13.6 4.9 0.28 11.3 4.9 2.0 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-P11 PF03854.14 EDO06676.1 - 3.9 7.2 11.5 5 6.9 3.9 3.2 2 1 1 3 3 3 0 P-11 zinc finger Zf_RING PF16744.5 EDO06676.1 - 5.6 7.2 7.1 0.6 10.3 1.4 2.4 2 1 1 3 3 3 0 KIAA1045 RING finger EXS PF03124.14 EDO06677.1 - 2.7e-68 230.7 22.8 4.1e-68 230.2 22.8 1.3 1 0 0 1 1 1 1 EXS family SPX PF03105.19 EDO06677.1 - 1.4e-10 41.7 1.8 8.9e-05 22.6 0.0 2.3 2 0 0 2 2 2 2 SPX domain WD40 PF00400.32 EDO06678.1 - 0.00012 22.8 3.3 0.067 14.1 0.0 3.4 3 0 0 3 3 3 3 WD domain, G-beta repeat ATG16 PF08614.11 EDO06680.1 - 0.0016 18.7 5.7 0.49 10.6 0.0 2.2 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) Fib_alpha PF08702.10 EDO06680.1 - 0.035 14.3 6.6 1.8 8.7 0.3 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family ANAPC4 PF12896.7 EDO06680.1 - 0.055 13.0 0.7 0.44 10.0 0.2 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 4 Fez1 PF06818.15 EDO06680.1 - 0.18 12.3 4.8 0.27 11.6 4.6 1.5 1 1 0 1 1 1 0 Fez1 DUF4407 PF14362.6 EDO06680.1 - 0.19 11.1 2.3 1.1 8.5 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) CorA PF01544.18 EDO06680.1 - 0.41 9.9 6.9 0.13 11.6 4.1 1.6 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein TBCC_N PF16752.5 EDO06680.1 - 0.45 11.0 5.4 0.31 11.5 3.0 1.9 2 1 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain PKcGMP_CC PF16808.5 EDO06680.1 - 0.78 9.7 5.3 0.24 11.3 0.4 2.6 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4164 PF13747.6 EDO06680.1 - 0.92 9.8 11.8 0.54 10.6 6.5 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4164) GYF PF02213.16 EDO06681.1 - 4.6e-13 48.6 4.0 1.1e-12 47.4 4.0 1.7 1 0 0 1 1 1 1 GYF domain ribosomal_L24 PF17136.4 EDO06682.1 - 4.4e-11 43.0 0.7 7.7e-11 42.2 0.1 1.8 2 0 0 2 2 2 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.29 EDO06682.1 - 5.2e-06 26.2 1.7 1e-05 25.3 1.7 1.5 1 0 0 1 1 1 1 KOW motif ET PF01684.16 EDO06684.1 - 0.048 14.0 0.5 0.23 11.8 0.5 2.2 1 0 0 1 1 1 0 ET module TAXi_C PF14541.6 EDO06684.1 - 0.098 12.4 0.0 0.23 11.2 0.0 1.7 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal Glutaredoxin PF00462.24 EDO06686.1 - 1.7e-18 66.6 0.0 5.1e-18 65.0 0.0 1.8 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin PF00085.20 EDO06686.1 - 0.0045 17.0 0.0 0.0088 16.0 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin GST_N_3 PF13417.6 EDO06686.1 - 0.0055 17.1 0.0 0.0098 16.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Thioredoxin_2 PF13098.6 EDO06686.1 - 0.0087 16.5 0.0 0.27 11.7 0.0 2.6 2 1 0 2 2 2 1 Thioredoxin-like domain SH3BGR PF04908.15 EDO06686.1 - 0.063 13.5 0.0 0.43 10.8 0.0 2.2 2 0 0 2 2 2 0 SH3-binding, glutamic acid-rich protein Methyltransf_23 PF13489.6 EDO06687.1 - 6.6e-18 65.1 0.0 8e-18 64.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDO06687.1 - 3.9e-17 62.7 0.0 7.4e-17 61.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDO06687.1 - 7.8e-17 61.8 0.0 1.9e-16 60.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDO06687.1 - 4e-15 55.9 0.0 6.2e-15 55.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDO06687.1 - 5.8e-14 52.6 0.1 2e-13 50.9 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EDO06687.1 - 3e-06 26.7 0.2 1.7e-05 24.3 0.2 1.9 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase MetW PF07021.12 EDO06687.1 - 5.2e-05 22.9 1.3 0.005 16.5 1.3 2.2 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_32 PF13679.6 EDO06687.1 - 9.1e-05 22.5 0.1 0.00015 21.7 0.1 1.4 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EDO06687.1 - 0.0001 21.8 0.0 0.00015 21.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EDO06687.1 - 0.00098 18.7 0.0 0.0015 18.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 EDO06687.1 - 0.0012 18.7 0.0 0.0023 17.7 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_9 PF08003.11 EDO06687.1 - 0.002 17.1 0.0 0.0031 16.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) NodS PF05401.11 EDO06687.1 - 0.003 17.2 0.2 0.12 12.0 0.2 2.1 1 1 0 1 1 1 1 Nodulation protein S (NodS) TehB PF03848.14 EDO06687.1 - 0.0036 16.7 0.1 0.012 15.1 0.1 1.8 1 1 0 1 1 1 1 Tellurite resistance protein TehB RrnaAD PF00398.20 EDO06687.1 - 0.024 13.7 0.0 0.036 13.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase TPMT PF05724.11 EDO06687.1 - 0.078 12.6 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) AdoMet_MTase PF07757.13 EDO06687.1 - 0.1 12.9 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase UDPG_MGDP_dh_N PF03721.14 EDO06687.1 - 0.13 11.8 0.3 0.26 10.8 0.3 1.4 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Cyclin_N PF00134.23 EDO06688.1 - 1.8e-10 40.7 0.6 3.6e-10 39.7 0.6 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Pkinase PF00069.25 EDO06689.1 - 8.1e-42 143.4 0.0 1e-41 143.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO06689.1 - 1.4e-26 93.4 0.0 1.8e-26 93.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDO06689.1 - 8.6e-05 22.0 0.2 0.00014 21.3 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ET PF01684.16 EDO06691.1 - 0.075 13.4 0.6 0.24 11.8 0.3 1.9 2 0 0 2 2 2 0 ET module TAXi_C PF14541.6 EDO06691.1 - 0.15 11.8 0.0 0.31 10.8 0.0 1.6 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal PIP49_C PF12260.8 EDO06692.1 - 0.1 12.2 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 Glutaredoxin PF00462.24 EDO06693.1 - 1.7e-18 66.6 0.0 5.1e-18 65.0 0.0 1.8 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin PF00085.20 EDO06693.1 - 0.0017 18.3 0.0 0.0034 17.3 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin GST_N_3 PF13417.6 EDO06693.1 - 0.0054 17.1 0.0 0.0098 16.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Thioredoxin_2 PF13098.6 EDO06693.1 - 0.037 14.5 0.0 1.1 9.7 0.0 2.6 2 1 0 2 2 2 0 Thioredoxin-like domain SH3BGR PF04908.15 EDO06693.1 - 0.061 13.5 0.0 0.43 10.8 0.0 2.2 2 0 0 2 2 2 0 SH3-binding, glutamic acid-rich protein Methyltransf_23 PF13489.6 EDO06694.1 - 2.4e-23 82.8 0.0 4.6e-23 81.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDO06694.1 - 6.3e-19 68.4 0.3 1.7e-18 67.1 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDO06694.1 - 2.4e-17 63.4 0.0 6.8e-17 62.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDO06694.1 - 1.2e-16 60.9 0.0 2e-16 60.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PDCD2_C PF04194.13 EDO06694.1 - 3.4e-15 56.5 0.0 3.3e-12 46.8 0.0 2.2 2 0 0 2 2 2 2 Programmed cell death protein 2, C-terminal putative domain Methyltransf_12 PF08242.12 EDO06694.1 - 2.7e-14 53.7 0.6 9.3e-14 52.0 0.1 2.2 2 1 0 2 2 1 1 Methyltransferase domain CMAS PF02353.20 EDO06694.1 - 1.2e-07 31.4 0.1 4.9e-07 29.3 0.1 1.8 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 EDO06694.1 - 2.2e-05 24.0 0.1 3.5e-05 23.3 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 EDO06694.1 - 0.00016 21.7 0.1 0.00033 20.7 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDO06694.1 - 0.00049 19.5 0.0 0.00098 18.5 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EDO06694.1 - 0.00078 19.3 0.1 0.0015 18.4 0.1 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_9 PF08003.11 EDO06694.1 - 0.00087 18.3 0.0 0.0015 17.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MetW PF07021.12 EDO06694.1 - 0.00094 18.8 1.3 0.046 13.3 1.3 2.2 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW NodS PF05401.11 EDO06694.1 - 0.0014 18.3 0.0 0.049 13.2 0.0 2.1 1 1 0 1 1 1 1 Nodulation protein S (NodS) MTS PF05175.14 EDO06694.1 - 0.0053 16.3 0.0 0.0094 15.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain TehB PF03848.14 EDO06694.1 - 0.0087 15.5 0.1 0.084 12.3 0.1 2.1 1 1 0 1 1 1 1 Tellurite resistance protein TehB TPMT PF05724.11 EDO06694.1 - 0.009 15.7 0.0 0.015 15.0 0.0 1.2 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) RrnaAD PF00398.20 EDO06694.1 - 0.04 13.0 0.2 0.088 11.9 0.0 1.6 2 0 0 2 2 2 0 Ribosomal RNA adenine dimethylase Pox_MCEL PF03291.16 EDO06694.1 - 0.15 11.1 0.0 0.27 10.3 0.0 1.3 1 0 0 1 1 1 0 mRNA capping enzyme ADH_zinc_N PF00107.26 EDO06694.1 - 0.16 11.9 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Topoisom_I PF01028.20 EDO06695.1 - 1.6e-103 344.9 1.7 3.4e-103 343.9 1.7 1.6 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 EDO06695.1 - 3.8e-77 258.6 1.8 3.8e-77 258.6 1.8 1.9 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 EDO06695.1 - 2e-32 110.9 0.3 6.2e-32 109.4 0.3 1.9 1 0 0 1 1 1 1 C-terminal topoisomerase domain Bromodomain PF00439.25 EDO06696.1 - 4.3e-13 49.1 0.4 1.4e-12 47.5 0.1 2.0 2 0 0 2 2 2 1 Bromodomain PIP5K PF01504.18 EDO06697.1 - 6.5e-76 255.2 0.1 2.8e-75 253.1 0.1 1.9 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase EF-hand_6 PF13405.6 EDO06697.1 - 6.1e-05 22.6 0.1 0.0028 17.5 0.0 2.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 EDO06697.1 - 0.00011 22.0 0.0 0.0006 19.6 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 EDO06697.1 - 0.00042 19.7 0.0 0.0012 18.3 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 EDO06697.1 - 0.00074 18.9 0.0 0.0035 16.8 0.0 2.2 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EDO06697.1 - 0.015 15.7 0.0 0.079 13.4 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain pair JAB PF01398.21 EDO06698.1 - 3e-30 104.6 0.0 6.2e-30 103.6 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 EDO06698.1 - 2.4e-09 37.0 0.0 4.6e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Phage_Gp23 PF10669.9 EDO06698.1 - 0.022 15.1 0.5 0.039 14.3 0.5 1.4 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Nop10p PF04135.12 EDO06699.1 - 0.038 14.0 0.1 0.081 13.0 0.1 1.6 1 0 0 1 1 1 0 Nucleolar RNA-binding protein, Nop10p family GFA PF04828.14 EDO06699.1 - 0.072 13.4 0.7 0.12 12.7 0.1 1.7 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Zn_ribbon_recom PF13408.6 EDO06699.1 - 0.083 13.4 0.9 0.15 12.6 0.9 1.3 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain TF_Zn_Ribbon PF08271.12 EDO06700.1 - 3.7e-08 32.8 0.5 7.3e-08 31.8 0.5 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding TFIIB PF00382.19 EDO06700.1 - 0.00021 21.2 0.0 0.0004 20.4 0.0 1.4 1 0 0 1 1 1 1 Transcription factor TFIIB repeat ArfGap PF01412.18 EDO06700.1 - 0.052 13.6 0.6 0.1 12.7 0.6 1.6 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf TraI_2B PF18340.1 EDO06700.1 - 0.11 12.6 0.1 0.31 11.1 0.1 1.9 1 0 0 1 1 1 0 DNA relaxase TraI 2B/2B-like domain OrfB_Zn_ribbon PF07282.11 EDO06700.1 - 0.11 12.4 2.7 0.16 11.9 1.0 2.0 1 1 1 2 2 2 0 Putative transposase DNA-binding domain LSM PF01423.22 EDO06700.1 - 0.21 11.3 2.0 16 5.3 2.0 2.4 1 1 0 1 1 1 0 LSM domain AAA_18 PF13238.6 EDO06701.1 - 2.6e-19 70.0 0.2 3.2e-19 69.8 0.2 1.1 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EDO06701.1 - 1.1e-10 42.1 0.0 2.7e-10 40.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 EDO06701.1 - 1.5e-05 25.0 0.1 0.0014 18.6 0.0 2.1 2 0 0 2 2 2 1 NTPase AAA PF00004.29 EDO06701.1 - 2.4e-05 24.8 0.0 3.5e-05 24.2 0.0 1.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDO06701.1 - 0.00011 22.7 0.1 0.00011 22.6 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 EDO06701.1 - 0.00061 20.1 0.0 0.0011 19.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDO06701.1 - 0.002 18.4 0.0 0.003 17.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain ADK PF00406.22 EDO06701.1 - 0.0021 18.2 0.0 0.25 11.4 0.0 2.1 2 0 0 2 2 2 1 Adenylate kinase RNA_helicase PF00910.22 EDO06701.1 - 0.004 17.5 0.0 0.031 14.7 0.0 2.0 2 0 0 2 2 2 1 RNA helicase AAA_33 PF13671.6 EDO06701.1 - 0.0052 17.0 0.0 0.021 15.0 0.1 1.8 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EDO06701.1 - 0.006 16.6 0.0 0.0074 16.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EDO06701.1 - 0.0065 16.2 0.0 0.015 15.0 0.0 1.6 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Zeta_toxin PF06414.12 EDO06701.1 - 0.011 15.0 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Cytidylate_kin PF02224.18 EDO06701.1 - 0.011 15.5 0.0 0.039 13.7 0.0 1.9 1 1 0 1 1 1 0 Cytidylate kinase KTI12 PF08433.10 EDO06701.1 - 0.013 15.0 0.0 0.018 14.5 0.0 1.1 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_19 PF13245.6 EDO06701.1 - 0.024 15.0 0.1 0.039 14.3 0.1 1.3 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 EDO06701.1 - 0.041 13.6 0.0 0.056 13.2 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.11 EDO06701.1 - 0.05 13.5 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Cytidylate_kin2 PF13189.6 EDO06701.1 - 0.067 13.3 0.0 0.1 12.7 0.0 1.6 1 1 0 1 1 1 0 Cytidylate kinase-like family DUF2075 PF09848.9 EDO06701.1 - 0.091 12.0 0.0 0.091 12.0 0.0 1.2 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 EDO06701.1 - 0.098 12.6 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain SKI PF01202.22 EDO06701.1 - 0.1 12.7 0.0 0.69 10.0 0.0 2.0 2 0 0 2 2 2 0 Shikimate kinase IstB_IS21 PF01695.17 EDO06701.1 - 0.14 11.9 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein TsaE PF02367.17 EDO06701.1 - 0.17 11.9 0.0 0.33 11.0 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EDO06701.1 - 0.22 11.0 0.0 0.31 10.5 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Methyltr_RsmB-F PF01189.17 EDO06702.1 - 1.1e-25 90.5 0.0 1.9e-19 70.1 0.0 2.5 1 1 1 2 2 2 2 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 EDO06702.1 - 1.4e-06 28.7 0.0 3.4e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF Ubie_methyltran PF01209.18 EDO06702.1 - 5.1e-05 22.7 0.0 9.4e-05 21.9 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EDO06702.1 - 0.069 12.9 0.0 8.4 6.2 0.0 2.3 1 1 1 2 2 2 0 Methyltransferase domain RNA_POL_M_15KD PF02150.16 EDO06704.1 - 2.6e-09 36.8 2.5 1e-08 34.9 0.9 2.2 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 EDO06704.1 - 8.8e-08 31.9 1.3 8.8e-08 31.9 1.3 4.0 4 1 0 4 4 4 1 Transcription factor S-II (TFIIS) DZR PF12773.7 EDO06704.1 - 0.029 14.4 1.6 0.52 10.4 0.4 2.4 2 0 0 2 2 2 0 Double zinc ribbon Lar_restr_allev PF14354.6 EDO06704.1 - 0.1 13.0 8.1 0.12 12.7 0.9 2.5 2 1 0 2 2 2 0 Restriction alleviation protein Lar OrfB_Zn_ribbon PF07282.11 EDO06704.1 - 0.11 12.4 5.9 2.3 8.2 0.2 2.5 2 1 1 3 3 3 0 Putative transposase DNA-binding domain zf-ribbon_3 PF13248.6 EDO06704.1 - 0.37 10.3 6.0 3 7.4 0.1 2.8 3 0 0 3 3 3 0 zinc-ribbon domain OrsD PF12013.8 EDO06704.1 - 0.37 11.2 1.9 8.7 6.8 0.3 2.4 2 1 0 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D zf_UBZ PF18439.1 EDO06704.1 - 0.6 9.8 6.0 3.9 7.2 0.1 3.0 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger RecR PF02132.15 EDO06704.1 - 1.8 8.2 6.7 4 7.1 2.9 2.8 2 1 0 2 2 2 0 RecR protein CpXC PF14353.6 EDO06704.1 - 3.2 7.8 6.6 0.81 9.7 0.6 2.8 1 1 2 3 3 3 0 CpXC protein Zn_Tnp_IS1595 PF12760.7 EDO06704.1 - 3.8 7.6 12.4 2.4 8.2 1.8 3.0 1 1 2 3 3 3 0 Transposase zinc-ribbon domain zf-LITAF-like PF10601.9 EDO06704.1 - 5.8 7.3 9.8 1.9 8.8 1.7 2.7 3 1 0 3 3 3 0 LITAF-like zinc ribbon domain zinc_ribbon_10 PF10058.9 EDO06704.1 - 8.3 6.2 8.8 17 5.2 0.0 3.2 3 1 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein Evr1_Alr PF04777.13 EDO06705.1 - 3.3e-16 59.6 0.0 4.9e-16 59.0 0.0 1.2 1 0 0 1 1 1 1 Erv1 / Alr family UQ_con PF00179.26 EDO06706.1 - 0.0051 16.5 0.4 0.013 15.2 0.1 1.9 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme UPF0262 PF06793.12 EDO06706.1 - 0.0089 16.1 0.3 0.046 13.8 0.2 2.0 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0262) Mod_r PF07200.13 EDO06706.1 - 0.29 11.2 14.7 1.5 8.9 12.7 2.5 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein FliJ PF02050.16 EDO06706.1 - 1.5 9.1 8.6 1 9.6 6.6 1.8 2 0 0 2 2 2 0 Flagellar FliJ protein DUF745 PF05335.13 EDO06706.1 - 6.2 6.5 6.5 21 4.8 5.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF745) IstB_IS21_ATP PF08483.11 EDO06707.1 - 0.15 12.0 0.1 0.24 11.3 0.1 1.3 1 0 0 1 1 1 0 IstB-like ATP binding N-terminal Sec23_trunk PF04811.15 EDO06709.1 - 4.4e-60 203.3 0.1 7.7e-60 202.5 0.1 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EDO06709.1 - 2.2e-34 118.1 0.3 2.2e-34 118.1 0.3 1.8 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 EDO06709.1 - 6.5e-23 80.5 0.3 1.5e-22 79.4 0.3 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 EDO06709.1 - 2.6e-13 49.8 2.3 5.9e-13 48.6 1.2 2.3 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EDO06709.1 - 1.3e-09 37.9 0.0 3.7e-09 36.4 0.0 1.9 1 0 0 1 1 1 1 Gelsolin repeat VWA_2 PF13519.6 EDO06709.1 - 6e-05 23.6 0.0 0.044 14.4 0.0 3.2 2 1 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 EDO06709.1 - 0.0028 17.9 0.5 0.022 15.0 0.0 2.7 3 0 0 3 3 3 1 von Willebrand factor type A domain Vps36-NZF-N PF16988.5 EDO06709.1 - 0.11 12.0 0.0 0.29 10.5 0.0 1.7 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain LSM PF01423.22 EDO06710.1 - 8.6e-17 60.6 0.1 1e-16 60.3 0.1 1.1 1 0 0 1 1 1 1 LSM domain DUF1336 PF07059.12 EDO06710.1 - 0.18 11.8 0.0 0.21 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1336) UPF0121 PF03661.13 EDO06711.1 - 4.9e-19 68.7 10.3 6.5e-19 68.3 10.3 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) FNIP PF05725.12 EDO06711.1 - 0.07 13.3 0.3 0.29 11.3 0.1 2.0 2 0 0 2 2 2 0 FNIP Repeat Pox_A14 PF05767.12 EDO06712.1 - 0.034 14.3 0.1 0.034 14.3 0.1 3.7 3 1 0 3 3 3 0 Poxvirus virion envelope protein A14 DUF2567 PF10821.8 EDO06712.1 - 0.092 12.8 0.0 0.26 11.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2567) BCAS2 PF05700.11 EDO06713.1 - 3.2e-14 53.1 0.6 1.2e-13 51.3 0.6 1.7 1 1 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) Pkinase PF00069.25 EDO06714.1 - 1.3e-63 214.9 0.0 2e-63 214.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO06714.1 - 1.9e-27 96.2 0.0 2.9e-27 95.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.6 EDO06714.1 - 5.5e-08 33.1 0.4 0.012 16.1 0.0 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EDO06714.1 - 2.9e-07 29.6 0.0 0.0015 17.9 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EDO06714.1 - 2.1e-06 27.5 0.2 0.0041 16.9 0.0 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_13 PF17958.1 EDO06714.1 - 0.00013 21.7 0.3 1.2 9.0 0.0 4.5 5 1 1 6 6 6 2 EF-hand domain EF-hand_5 PF13202.6 EDO06714.1 - 0.0012 18.2 0.0 0.37 10.4 0.0 2.8 2 0 0 2 2 2 1 EF hand Kinase-like PF14531.6 EDO06714.1 - 0.002 17.5 0.0 0.0035 16.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like EF-hand_6 PF13405.6 EDO06714.1 - 0.0025 17.6 0.2 2.2 8.4 0.0 3.0 2 0 0 2 2 2 1 EF-hand domain Kdo PF06293.14 EDO06714.1 - 0.014 14.8 0.1 0.03 13.7 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDO06714.1 - 0.043 13.7 0.0 0.074 13.0 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF3490 PF11995.8 EDO06714.1 - 0.054 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3490) ADIP PF11559.8 EDO06715.1 - 0.0074 16.4 4.7 0.0074 16.4 4.7 4.4 3 2 2 5 5 5 2 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 EDO06715.1 - 0.72 10.0 30.2 6.7 6.9 8.9 3.8 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) KASH_CCD PF14662.6 EDO06715.1 - 1.4 8.7 42.5 0.018 14.9 25.1 3.9 3 1 2 5 5 5 0 Coiled-coil region of CCDC155 or KASH HMMR_N PF15905.5 EDO06715.1 - 8.2 5.8 44.2 2.4 7.6 21.8 3.0 2 1 1 3 3 3 0 Hyaluronan mediated motility receptor N-terminal EF-G-binding_N PF07299.11 EDO06716.1 - 0.029 14.9 3.9 0.089 13.3 1.1 2.9 1 1 1 3 3 3 0 Elongation factor G-binding protein, N-terminal V_ATPase_I PF01496.19 EDO06716.1 - 0.036 12.0 2.1 0.036 12.0 2.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GP41 PF00517.17 EDO06716.1 - 0.043 13.7 0.2 0.073 13.0 0.2 1.3 1 0 0 1 1 1 0 Retroviral envelope protein Mycoplasma_p37 PF06646.11 EDO06716.1 - 0.077 12.2 0.3 0.12 11.6 0.3 1.4 1 0 0 1 1 1 0 High affinity transport system protein p37 WGG PF10273.9 EDO06716.1 - 0.13 12.9 3.8 1.4 9.6 0.2 2.9 3 0 0 3 3 3 0 Pre-rRNA-processing protein TSR2 Vir_act_alpha_C PF10400.9 EDO06716.1 - 0.55 11.0 3.2 2.5 8.9 3.2 2.2 1 1 0 1 1 1 0 Virulence activator alpha C-term Seryl_tRNA_N PF02403.22 EDO06716.1 - 0.58 10.4 7.7 0.59 10.4 1.0 2.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain TMPIT PF07851.13 EDO06716.1 - 0.9 8.7 2.9 1.3 8.2 2.9 1.2 1 0 0 1 1 1 0 TMPIT-like protein APG6_N PF17675.1 EDO06716.1 - 1.2 9.7 15.3 0.24 12.0 8.5 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region PRKG1_interact PF15898.5 EDO06716.1 - 1.2 10.1 9.6 3.9 8.4 7.3 2.7 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain YabA PF06156.13 EDO06716.1 - 1.7 9.3 4.4 5.4 7.7 4.0 2.1 1 1 1 2 2 2 0 Initiation control protein YabA Spc24 PF08286.11 EDO06716.1 - 3.2 8.0 11.7 44 4.4 11.7 2.4 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 DUF4140 PF13600.6 EDO06716.1 - 5.5 7.5 6.3 2.5 8.6 2.1 2.6 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) RabGAP-TBC PF00566.18 EDO06717.1 - 6.5e-51 173.0 1.0 9.6e-51 172.5 1.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain ADK PF00406.22 EDO06718.1 - 2.6e-29 102.3 0.0 3.3e-29 101.9 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EDO06718.1 - 5.3e-23 81.9 0.0 7.4e-23 81.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDO06718.1 - 7.4e-12 45.6 0.0 5.1e-11 42.9 0.0 1.9 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.6 EDO06718.1 - 1.1e-08 35.6 0.0 2.2e-08 34.7 0.0 1.4 2 0 0 2 2 1 1 AAA domain RNA_helicase PF00910.22 EDO06718.1 - 0.00069 20.0 0.0 0.013 15.8 0.0 2.4 1 1 0 1 1 1 1 RNA helicase Cytidylate_kin PF02224.18 EDO06718.1 - 0.0007 19.4 0.0 0.0012 18.6 0.0 1.5 2 0 0 2 2 2 1 Cytidylate kinase AAA_22 PF13401.6 EDO06718.1 - 0.0012 19.1 0.0 0.002 18.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain dNK PF01712.19 EDO06718.1 - 0.0025 17.7 0.1 0.043 13.7 0.0 2.3 2 1 0 2 2 2 1 Deoxynucleoside kinase PRK PF00485.18 EDO06718.1 - 0.0028 17.4 0.0 0.0044 16.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_5 PF07728.14 EDO06718.1 - 0.0028 17.7 0.0 0.0065 16.5 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 EDO06718.1 - 0.0089 15.3 0.1 0.07 12.4 0.0 2.3 2 1 1 3 3 3 1 Zeta toxin AAA_16 PF13191.6 EDO06718.1 - 0.018 15.5 0.0 0.13 12.6 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_19 PF13245.6 EDO06718.1 - 0.041 14.2 0.1 0.42 11.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 EDO06718.1 - 0.046 13.5 0.0 0.08 12.7 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_29 PF13555.6 EDO06718.1 - 0.05 13.4 0.1 0.25 11.1 0.0 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA PF00004.29 EDO06718.1 - 0.059 13.8 0.0 0.097 13.1 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Ploopntkinase3 PF18751.1 EDO06718.1 - 0.075 12.9 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 ATPase PF06745.13 EDO06718.1 - 0.079 12.3 0.1 0.19 11.1 0.0 1.6 2 0 0 2 2 2 0 KaiC CoaE PF01121.20 EDO06718.1 - 0.079 12.6 0.0 0.37 10.4 0.0 1.9 2 0 0 2 2 2 0 Dephospho-CoA kinase Rad17 PF03215.15 EDO06718.1 - 0.079 12.9 0.0 0.21 11.5 0.0 1.8 1 1 0 1 1 1 0 Rad17 P-loop domain AAA_28 PF13521.6 EDO06718.1 - 0.084 13.1 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain HicB_lk_antitox PF15919.5 EDO06718.1 - 0.088 12.9 0.0 0.26 11.4 0.0 1.7 2 0 0 2 2 2 0 HicB_like antitoxin of bacterial toxin-antitoxin system MeaB PF03308.16 EDO06718.1 - 0.1 11.6 0.0 0.21 10.5 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CPT PF07931.12 EDO06718.1 - 0.11 12.4 0.3 0.49 10.2 0.1 2.1 1 1 1 2 2 2 0 Chloramphenicol phosphotransferase-like protein NB-ARC PF00931.22 EDO06718.1 - 0.11 11.7 0.0 0.19 10.9 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain KTI12 PF08433.10 EDO06718.1 - 0.12 11.8 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 T2SSE PF00437.20 EDO06718.1 - 0.12 11.4 0.0 0.2 10.7 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein NTPase_1 PF03266.15 EDO06718.1 - 0.13 12.2 0.0 0.28 11.1 0.0 1.6 1 1 0 1 1 1 0 NTPase AAA_24 PF13479.6 EDO06718.1 - 0.13 11.9 0.1 0.41 10.3 0.0 1.8 2 1 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EDO06718.1 - 0.16 11.7 0.0 0.27 10.9 0.0 1.6 2 0 0 2 2 1 0 AAA domain ATP_bind_1 PF03029.17 EDO06718.1 - 0.17 11.7 0.1 0.29 10.9 0.1 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_14 PF13173.6 EDO06718.1 - 0.19 11.8 0.0 0.4 10.7 0.0 1.6 1 1 0 1 1 1 0 AAA domain SMC_N PF02463.19 EDO06718.1 - 0.22 10.9 0.0 0.32 10.4 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain UPF0203 PF05254.12 EDO06719.1 - 8.8e-12 45.1 7.4 1.1e-11 44.8 7.4 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) CX9C PF16860.5 EDO06719.1 - 0.0012 18.8 5.0 0.078 13.0 0.9 2.8 2 1 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, GCK PF07802.11 EDO06719.1 - 0.014 15.8 3.7 1.6 9.2 0.4 2.1 1 1 1 2 2 2 0 GCK domain CHCH PF06747.13 EDO06719.1 - 0.014 15.5 5.6 0.62 10.3 0.2 3.1 3 0 0 3 3 3 0 CHCH domain COX17 PF05051.13 EDO06719.1 - 0.024 15.0 5.0 0.051 13.9 2.5 2.4 1 1 2 3 3 3 0 Cytochrome C oxidase copper chaperone (COX17) Cmc1 PF08583.10 EDO06719.1 - 0.033 14.2 7.1 0.18 11.9 7.1 2.1 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like UCR_hinge PF02320.16 EDO06719.1 - 1.5 9.1 9.4 5.5 7.3 1.2 2.1 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein DUF1687 PF07955.11 EDO06720.1 - 0.014 15.9 0.2 0.023 15.2 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1687) SOAR PF16533.5 EDO06720.1 - 0.064 13.2 2.5 0.099 12.6 2.2 1.5 1 1 0 1 1 1 0 STIM1 Orai1-activating region TMEM215 PF15746.5 EDO06720.1 - 0.07 12.6 0.1 0.098 12.1 0.1 1.2 1 0 0 1 1 1 0 TMEM215 family TFX_C PF14601.6 EDO06720.1 - 0.11 12.5 0.1 0.17 11.9 0.1 1.3 1 0 0 1 1 1 0 DNA_binding protein, TFX, C-term TBCC_N PF16752.5 EDO06720.1 - 0.13 12.7 1.7 7.3 7.1 0.3 2.1 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain ThiF PF00899.21 EDO06721.1 - 2.5e-91 305.4 0.0 5.4e-61 206.1 0.0 2.4 2 1 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 EDO06721.1 - 8.9e-60 202.7 2.8 1.3e-59 202.2 2.8 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 EDO06721.1 - 8.9e-22 77.1 0.4 2.4e-21 75.7 0.4 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_UFD PF09358.10 EDO06721.1 - 6.5e-20 71.6 0.0 2.7e-19 69.7 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin fold domain E1_4HB PF16191.5 EDO06721.1 - 0.0032 17.6 0.0 0.01 16.0 0.0 1.9 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle Shikimate_DH PF01488.20 EDO06721.1 - 0.098 12.7 3.8 17 5.5 1.0 3.5 2 1 1 3 3 3 0 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 EDO06721.1 - 0.29 11.7 2.8 14 6.3 0.0 3.1 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Vac14_Fab1_bd PF12755.7 EDO06722.1 - 3.9e-25 88.3 0.1 3.9e-25 88.3 0.1 3.9 4 1 1 5 5 5 1 Vacuolar 14 Fab1-binding region Vac14_Fig4_bd PF11916.8 EDO06722.1 - 2.5e-20 72.9 0.1 2.5e-20 72.9 0.1 2.3 3 0 0 3 3 3 1 Vacuolar protein 14 C-terminal Fig4p binding TFCD_C PF12612.8 EDO06722.1 - 0.029 14.2 4.8 0.074 12.9 1.5 2.8 2 1 0 2 2 2 0 Tubulin folding cofactor D C terminal HEAT PF02985.22 EDO06722.1 - 0.1 12.9 0.2 0.89 10.0 0.0 2.8 2 0 0 2 2 2 0 HEAT repeat Rimk_N PF18030.1 EDO06723.1 - 0.18 12.2 0.0 0.38 11.2 0.0 1.5 1 0 0 1 1 1 0 RimK PreATP-grasp domain TatD_DNase PF01026.21 EDO06724.1 - 7.2e-48 163.2 0.0 8.4e-48 163.0 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase Amidohydro_2 PF04909.14 EDO06724.1 - 0.028 14.2 0.0 0.18 11.6 0.0 2.0 2 0 0 2 2 2 0 Amidohydrolase Kinesin PF00225.23 EDO06725.1 - 5.7e-82 275.3 0.1 7.7e-82 274.9 0.1 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EDO06725.1 - 5.7e-14 52.3 0.0 1.4e-13 51.0 0.1 1.7 2 0 0 2 2 2 1 Microtubule binding UvrA_inter PF17760.1 EDO06725.1 - 0.1 12.7 0.1 0.43 10.7 0.1 2.2 1 1 0 1 1 1 0 UvrA interaction domain Phage_holin_3_6 PF07332.11 EDO06726.1 - 0.02 14.9 2.2 0.02 14.9 2.2 4.5 4 2 0 4 4 4 0 Putative Actinobacterial Holin-X, holin superfamily III DUF1600 PF07667.11 EDO06726.1 - 0.77 10.0 17.9 0.29 11.3 3.2 3.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1600) Herpes_LMP1 PF05297.11 EDO06726.1 - 4.7 6.3 8.1 17 4.5 8.1 2.0 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) RELT PF12606.8 EDO06729.1 - 0.0017 17.3 2.6 0.0042 16.1 2.6 1.7 1 0 0 1 1 1 1 Tumour necrosis factor receptor superfamily member 19 TspO_MBR PF03073.15 EDO06729.1 - 0.0034 17.5 1.0 0.0034 17.5 1.0 1.5 2 0 0 2 2 2 1 TspO/MBR family Connexin PF00029.19 EDO06729.1 - 0.0063 16.3 0.0 0.0078 16.0 0.0 1.1 1 0 0 1 1 1 1 Connexin Fer4_5 PF12801.7 EDO06730.1 - 0.036 14.0 3.8 0.036 14.0 3.8 4.1 4 0 0 4 4 4 0 4Fe-4S binding domain DUF3624 PF12292.8 EDO06730.1 - 0.15 12.5 0.5 0.15 12.5 0.5 3.9 3 2 1 4 4 4 0 Protein of unknown function (DUF3624) DUF2569 PF10754.9 EDO06730.1 - 2.3 8.6 26.6 0.027 14.9 8.5 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2569) VESA1_N PF12785.7 EDO06731.1 - 2.1e-205 683.0 55.7 1.5e-196 653.8 23.2 4.2 3 1 1 4 4 4 3 Variant erythrocyte surface antigen-1 Enolase_C PF00113.22 EDO06731.1 - 0.041 13.1 1.0 0.064 12.5 1.0 1.2 1 0 0 1 1 1 0 Enolase, C-terminal TIM barrel domain F-box-like_2 PF13013.6 EDO06732.1 - 3.4e-07 30.2 0.3 5.7e-07 29.5 0.3 1.3 1 0 0 1 1 1 1 F-box-like domain Methyltransf_28 PF02636.17 EDO06732.1 - 0.047 13.3 0.0 0.057 13.0 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase VESA1_N PF12785.7 EDO06733.1 - 3.3e-14 52.7 3.0 3.8e-14 52.5 3.0 1.0 1 0 0 1 1 1 1 Variant erythrocyte surface antigen-1 7tm_3 PF00003.22 EDO06735.1 - 0.0013 18.5 0.3 0.0014 18.4 0.3 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR AA_permease PF00324.21 EDO06735.1 - 0.0048 15.5 0.6 0.0066 15.1 0.6 1.2 1 0 0 1 1 1 1 Amino acid permease Serpentine_r_xa PF03383.15 EDO06735.1 - 0.0058 16.6 0.1 0.0081 16.1 0.1 1.1 1 0 0 1 1 1 1 Caenorhabditis serpentine receptor-like protein, class xa Baculo_11_kDa PF06143.11 EDO06735.1 - 0.012 15.1 1.4 0.38 10.3 0.3 2.3 2 0 0 2 2 2 0 Baculovirus 11 kDa family LptF_LptG PF03739.14 EDO06735.1 - 0.031 13.1 0.0 0.036 12.9 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG DUF998 PF06197.13 EDO06735.1 - 0.038 13.6 6.2 0.12 11.9 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF998) TMEM237 PF15383.6 EDO06735.1 - 0.076 12.1 0.8 1.2 8.2 0.1 2.0 2 0 0 2 2 2 0 Transmembrane protein 237 OST3_OST6 PF04756.13 EDO06735.1 - 0.11 11.9 2.0 0.14 11.5 2.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family DUF2207 PF09972.9 EDO06735.1 - 0.11 11.2 0.2 0.13 11.0 0.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4064 PF13273.6 EDO06735.1 - 0.16 12.3 3.7 0.33 11.2 3.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4064) DUF1772 PF08592.11 EDO06735.1 - 0.3 11.4 5.6 1.6 9.0 5.6 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) DUF4282 PF14110.6 EDO06735.1 - 0.31 11.8 4.8 0.62 10.8 4.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4282) DUF3671 PF12420.8 EDO06735.1 - 0.45 10.6 4.4 3 8.0 4.1 2.4 2 1 0 2 2 2 0 Protein of unknown function TMEM154 PF15102.6 EDO06735.1 - 0.91 9.4 3.3 3.5 7.5 0.0 2.2 2 0 0 2 2 2 0 TMEM154 protein family Pox_EPC_I2-L1 PF12575.8 EDO06735.1 - 2.2 8.6 6.9 0.53 10.5 0.3 2.2 1 1 1 2 2 2 0 Poxvirus entry protein complex L1 and I2 OppC_N PF12911.7 EDO06735.1 - 7.1 6.7 7.5 24 5.0 1.1 2.4 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C FeoB_associated PF12669.7 EDO06735.1 - 9.5 6.7 11.7 4.4 7.8 2.6 2.7 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein ACDC PF14733.6 EDO06736.1 - 0.00043 20.6 0.1 0.0011 19.2 0.1 1.8 1 0 0 1 1 1 1 AP2-coincident C-terminal DUF1411 PF07199.11 EDO06736.1 - 0.044 13.5 0.0 0.17 11.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1411) DrrA_P4M PF14860.6 EDO06736.1 - 0.05 13.5 0.1 2.9 7.8 0.0 2.9 2 0 0 2 2 2 0 DrrA phosphatidylinositol 4-phosphate binding domain Actin PF00022.19 EDO06737.1 - 2e-46 158.5 0.0 2.8e-46 158.0 0.0 1.2 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EDO06737.1 - 0.012 14.4 0.1 0.017 13.9 0.1 1.3 1 0 0 1 1 1 0 MreB/Mbl protein SNAPc_SNAP43 PF09808.9 EDO06738.1 - 0.00035 20.5 0.0 0.0007 19.6 0.0 1.6 1 1 0 1 1 1 1 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 MtN3_slv PF03083.16 EDO06739.1 - 3.4e-25 87.9 17.1 5.1e-15 55.3 2.8 2.3 2 0 0 2 2 2 2 Sugar efflux transporter for intercellular exchange LAB_N PF07578.11 EDO06739.1 - 0.078 13.1 0.6 0.078 13.1 0.6 3.0 3 0 0 3 3 3 0 Lipid A Biosynthesis N-terminal domain PsbX PF06596.11 EDO06739.1 - 1.3 9.1 4.5 32 4.6 1.2 3.0 2 1 0 2 2 2 0 Photosystem II reaction centre X protein (PsbX) ATP_bind_1 PF03029.17 EDO06740.1 - 5.1e-63 213.1 0.0 6e-63 212.8 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CbiA PF01656.23 EDO06740.1 - 7.1e-05 22.9 0.0 9.1e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_30 PF13604.6 EDO06740.1 - 0.014 15.2 0.0 0.022 14.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain CLP1_P PF16575.5 EDO06740.1 - 0.015 15.1 0.0 0.072 12.9 0.0 1.9 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop MeaB PF03308.16 EDO06740.1 - 0.019 13.9 0.0 0.03 13.3 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 EDO06740.1 - 0.045 14.2 0.0 0.13 12.6 0.0 1.9 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.6 EDO06740.1 - 0.11 13.0 0.1 0.24 11.9 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EDO06740.1 - 0.11 12.2 0.0 0.44 10.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EDO06740.1 - 0.12 12.9 0.4 0.2 12.1 0.4 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EDO06740.1 - 0.19 11.8 0.0 0.3 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 EDO06740.1 - 0.19 11.5 0.0 0.4 10.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 EDO06740.1 - 0.24 11.6 0.0 0.37 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain CLP_protease PF00574.23 EDO06741.1 - 2.6e-58 196.9 0.1 3.1e-58 196.7 0.1 1.0 1 0 0 1 1 1 1 Clp protease VirE_N PF08800.10 EDO06741.1 - 0.041 14.0 0.1 0.14 12.2 0.0 1.8 2 0 0 2 2 2 0 VirE N-terminal domain PfkB PF00294.24 EDO06742.1 - 3e-31 108.8 0.0 4.2e-31 108.4 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase MtN3_slv PF03083.16 EDO06743.1 - 3.4e-25 87.9 17.1 5.1e-15 55.3 2.8 2.3 2 0 0 2 2 2 2 Sugar efflux transporter for intercellular exchange LAB_N PF07578.11 EDO06743.1 - 0.078 13.1 0.6 0.078 13.1 0.6 3.0 3 0 0 3 3 3 0 Lipid A Biosynthesis N-terminal domain PsbX PF06596.11 EDO06743.1 - 1.3 9.1 4.5 32 4.6 1.2 3.0 2 1 0 2 2 2 0 Photosystem II reaction centre X protein (PsbX) ATP_bind_1 PF03029.17 EDO06745.1 - 5.1e-63 213.1 0.0 6e-63 212.8 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CbiA PF01656.23 EDO06745.1 - 7.1e-05 22.9 0.0 9.1e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_30 PF13604.6 EDO06745.1 - 0.014 15.2 0.0 0.022 14.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain CLP1_P PF16575.5 EDO06745.1 - 0.015 15.1 0.0 0.072 12.9 0.0 1.9 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop MeaB PF03308.16 EDO06745.1 - 0.019 13.9 0.0 0.03 13.3 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 EDO06745.1 - 0.045 14.2 0.0 0.13 12.6 0.0 1.9 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.6 EDO06745.1 - 0.11 13.0 0.1 0.24 11.9 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EDO06745.1 - 0.11 12.2 0.0 0.44 10.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EDO06745.1 - 0.12 12.9 0.4 0.2 12.1 0.4 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EDO06745.1 - 0.19 11.8 0.0 0.3 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 EDO06745.1 - 0.19 11.5 0.0 0.4 10.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 EDO06745.1 - 0.24 11.6 0.0 0.37 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain CLP_protease PF00574.23 EDO06746.1 - 5e-58 196.0 0.1 6.3e-58 195.7 0.1 1.1 1 0 0 1 1 1 1 Clp protease VirE_N PF08800.10 EDO06746.1 - 0.064 13.4 0.0 0.21 11.7 0.0 1.8 2 0 0 2 2 2 0 VirE N-terminal domain PfkB PF00294.24 EDO06747.1 - 4.3e-37 128.0 0.0 6.1e-37 127.6 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 EDO06747.1 - 0.12 11.8 0.0 0.29 10.5 0.0 1.6 2 0 0 2 2 2 0 Phosphomethylpyrimidine kinase ThiF PF00899.21 EDO06748.1 - 3.5e-48 164.1 0.6 5.4e-48 163.5 0.6 1.2 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 EDO06748.1 - 0.0012 19.4 0.0 0.0041 17.6 0.0 1.9 2 0 0 2 2 2 1 Rhodanese-like domain Shikimate_DH PF01488.20 EDO06748.1 - 0.0083 16.2 0.1 0.072 13.1 0.0 2.2 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase DapB_N PF01113.20 EDO06748.1 - 0.054 13.6 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus BclA_C PF18573.1 EDO06748.1 - 0.096 12.6 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 BclA C-terminal domain UDPG_MGDP_dh_N PF03721.14 EDO06748.1 - 0.12 12.0 0.2 0.19 11.3 0.2 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DnaJ PF00226.31 EDO06749.1 - 0.017 15.2 0.3 0.041 14.0 0.0 1.7 2 0 0 2 2 2 0 DnaJ domain Rad60-SLD PF11976.8 EDO06751.1 - 1.3e-22 79.4 0.0 1.5e-22 79.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EDO06751.1 - 2.8e-11 43.0 0.0 3.2e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family UBX PF00789.20 EDO06751.1 - 0.057 13.6 0.0 0.08 13.1 0.0 1.2 1 0 0 1 1 1 0 UBX domain HEAT PF02985.22 EDO06752.1 - 0.043 14.1 3.7 12 6.5 0.2 4.1 4 0 0 4 4 4 0 HEAT repeat Laminin_II PF06009.12 EDO06753.1 - 0.00057 19.9 2.8 0.00094 19.2 2.8 1.3 1 0 0 1 1 1 1 Laminin Domain II Seryl_tRNA_N PF02403.22 EDO06753.1 - 0.001 19.3 4.9 0.0016 18.6 4.9 1.3 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain DUF812 PF05667.11 EDO06753.1 - 0.0013 17.8 2.4 0.0017 17.3 2.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) TMF_TATA_bd PF12325.8 EDO06753.1 - 0.025 14.8 6.6 0.04 14.2 6.6 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding V_ATPase_I PF01496.19 EDO06753.1 - 0.19 9.6 0.4 0.26 9.2 0.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family YabA PF06156.13 EDO06753.1 - 0.39 11.4 1.8 0.81 10.4 1.8 1.5 1 0 0 1 1 1 0 Initiation control protein YabA Occludin_ELL PF07303.13 EDO06753.1 - 0.41 11.4 3.7 0.19 12.5 0.8 1.9 2 0 0 2 2 2 0 Occludin homology domain RAP PF08373.10 EDO06754.1 - 1.3e-16 60.4 0.7 3.2e-16 59.1 0.7 1.7 1 0 0 1 1 1 1 RAP domain MTES_1575 PF18741.1 EDO06754.1 - 0.0012 19.0 0.2 0.019 15.2 0.0 2.4 2 0 0 2 2 2 1 REase_MTES_1575 DUF559 PF04480.12 EDO06754.1 - 0.0026 17.6 0.1 0.0086 15.9 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF559) Myb_DNA-bind_6 PF13921.6 EDO06755.1 - 5.5e-17 61.8 3.0 1.8e-15 56.9 0.3 3.2 4 0 0 4 4 4 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EDO06755.1 - 0.0095 16.1 0.9 11 6.3 0.4 3.2 3 0 0 3 3 3 2 Myb-like DNA-binding domain DUF2286 PF10051.9 EDO06755.1 - 0.042 13.6 0.1 0.22 11.3 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2286) PriCT_2 PF08707.11 EDO06755.1 - 0.11 12.9 0.0 1.2 9.6 0.0 2.3 2 0 0 2 2 2 0 Primase C terminal 2 (PriCT-2) Myosin_tail_1 PF01576.19 EDO06756.1 - 0.0026 15.7 0.1 0.0026 15.7 0.1 1.1 1 0 0 1 1 1 1 Myosin tail DUF2507 PF10702.9 EDO06756.1 - 0.11 12.4 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2507) Hira PF07569.11 EDO06757.1 - 0.15 11.8 0.0 0.38 10.4 0.0 1.6 2 0 0 2 2 2 0 TUP1-like enhancer of split RRM_1 PF00076.22 EDO06758.1 - 2.5e-22 78.5 0.3 7.6e-22 76.9 0.2 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDO06758.1 - 7e-05 22.6 0.0 0.00023 20.9 0.0 1.9 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_7 PF16367.5 EDO06758.1 - 0.0013 18.8 0.0 0.0029 17.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.6 EDO06758.1 - 0.0013 18.3 0.0 0.0026 17.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RepB-RCR_reg PF10723.9 EDO06758.1 - 0.003 17.5 0.1 0.0052 16.7 0.1 1.5 1 0 0 1 1 1 1 Replication regulatory protein RepB RRM_3 PF08777.11 EDO06758.1 - 0.084 12.9 1.5 0.37 10.9 0.0 2.2 2 0 0 2 2 2 0 RNA binding motif Nup35_RRM_2 PF14605.6 EDO06758.1 - 0.096 12.7 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif XS PF03468.14 EDO06758.1 - 0.15 12.3 0.4 0.7 10.2 0.1 1.9 1 1 0 2 2 2 0 XS domain PHM7_cyt PF14703.6 EDO06758.1 - 0.28 11.4 2.0 8.2 6.6 0.0 2.9 2 2 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter AAR2 PF05282.11 EDO06760.1 - 1.1e-75 255.3 0.0 2.7e-75 254.0 0.0 1.6 1 1 0 1 1 1 1 AAR2 protein Bromodomain PF00439.25 EDO06761.1 - 4.9e-09 36.1 0.2 1.1e-08 35.1 0.2 1.6 1 0 0 1 1 1 1 Bromodomain WD40 PF00400.32 EDO06761.1 - 2.6e-06 28.1 12.8 0.19 12.6 0.4 6.0 5 0 0 5 5 5 3 WD domain, G-beta repeat zf-HC5HC2H PF13771.6 EDO06761.1 - 1.6e-05 25.0 1.4 8.1e-05 22.8 1.4 2.3 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EDO06761.1 - 0.0018 18.4 1.3 0.0077 16.4 1.3 2.1 1 0 0 1 1 1 1 PHD-zinc-finger like domain UTP15_C PF09384.10 EDO06762.1 - 5.4e-24 84.6 0.1 9.2e-24 83.8 0.1 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 EDO06762.1 - 1.1e-14 54.5 11.5 0.0012 19.7 0.1 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO06762.1 - 3.2e-09 37.0 0.1 0.14 12.5 0.0 5.2 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Dexa_ind PF15198.6 EDO06763.1 - 0.1 12.7 0.3 0.39 10.8 0.0 2.0 2 0 0 2 2 2 0 Dexamethasone-induced Ribosomal_S11 PF00411.19 EDO06765.1 - 0.00028 21.3 0.1 0.0004 20.8 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S11 Ribosomal_L18p PF00861.22 EDO06765.1 - 0.0011 19.4 0.1 0.0022 18.3 0.1 1.6 1 1 0 1 1 1 1 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast NifU_N PF01592.16 EDO06766.1 - 2.7e-47 160.1 0.2 3.2e-47 159.9 0.2 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain 6PGD PF00393.19 EDO06767.1 - 1.5e-91 306.8 0.5 1.8e-91 306.5 0.5 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EDO06767.1 - 6.5e-33 114.1 0.0 1.2e-32 113.3 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 EDO06767.1 - 0.0039 17.1 0.0 0.0078 16.1 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 EDO06767.1 - 0.12 12.0 0.0 0.28 10.7 0.0 1.6 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Col_cuticle_N PF01484.17 EDO06768.1 - 0.17 11.9 0.1 0.88 9.7 0.0 2.0 2 0 0 2 2 2 0 Nematode cuticle collagen N-terminal domain UvrD_C PF13361.6 EDO06768.1 - 1.8 7.9 5.1 1.3 8.3 3.0 1.8 2 1 0 2 2 2 0 UvrD-like helicase C-terminal domain CdvA PF18822.1 EDO06768.1 - 7.7 6.4 7.0 7 6.5 0.8 2.5 2 0 0 2 2 2 0 CdvA-like coiled-coil domain HC2 PF07382.11 EDO06769.1 - 0.0007 19.7 34.7 0.0007 19.7 34.7 2.4 2 0 0 2 2 2 1 Histone H1-like nucleoprotein HC2 ASFV_J13L PF05568.11 EDO06769.1 - 0.32 10.7 4.2 0.85 9.3 4.2 1.7 1 0 0 1 1 1 0 African swine fever virus J13L protein Alg14 PF08660.11 EDO06770.1 - 1.9e-40 138.6 0.1 2.5e-40 138.3 0.1 1.1 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like PglD_N PF17836.1 EDO06770.1 - 0.0087 16.7 0.0 0.041 14.5 0.0 2.0 2 0 0 2 2 2 1 PglD N-terminal domain MMR_HSR1 PF01926.23 EDO06771.1 - 5.8e-17 61.8 0.0 1.1e-16 60.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDO06771.1 - 8.2e-09 35.2 0.0 0.00032 20.3 0.0 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B Dynamin_N PF00350.23 EDO06771.1 - 1.4e-05 25.2 0.0 0.0075 16.3 0.0 2.3 2 0 0 2 2 2 2 Dynamin family GTP_EFTU PF00009.27 EDO06771.1 - 1.9e-05 24.3 0.0 0.024 14.2 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EDO06771.1 - 0.00016 21.6 0.0 0.0025 17.8 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase Septin PF00735.18 EDO06771.1 - 0.00027 20.3 0.0 0.00057 19.3 0.0 1.4 1 0 0 1 1 1 1 Septin TniB PF05621.11 EDO06771.1 - 0.0011 18.4 0.1 0.0036 16.7 0.0 1.7 2 0 0 2 2 2 1 Bacterial TniB protein AIG1 PF04548.16 EDO06771.1 - 0.015 14.7 0.0 0.044 13.1 0.0 1.8 2 0 0 2 2 2 0 AIG1 family IIGP PF05049.13 EDO06771.1 - 0.024 13.7 0.0 0.2 10.7 0.0 2.0 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) Roc PF08477.13 EDO06771.1 - 0.036 14.3 0.0 0.071 13.3 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase zf-RING_4 PF14570.6 EDO06772.1 - 2e-19 69.1 12.1 4e-19 68.1 12.1 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 EDO06772.1 - 7.5e-08 32.1 7.2 1.4e-07 31.3 7.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.22 EDO06772.1 - 0.00018 21.2 0.0 0.00043 20.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDO06772.1 - 0.0015 18.5 0.1 0.0033 17.4 0.1 1.6 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif zf-RING_2 PF13639.6 EDO06772.1 - 0.047 14.0 10.6 0.11 12.8 10.6 1.7 1 0 0 1 1 1 0 Ring finger domain Torus PF16131.5 EDO06772.1 - 0.06 14.0 0.3 0.06 14.0 0.3 2.2 2 0 0 2 2 2 0 Torus domain zf-UDP PF14569.6 EDO06772.1 - 0.066 13.3 3.1 0.15 12.2 3.1 1.5 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-C3HC4 PF00097.25 EDO06772.1 - 0.28 11.1 10.7 0.59 10.1 10.7 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDO06772.1 - 0.51 10.2 6.1 5.5 6.9 6.6 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EDO06772.1 - 2.1 8.3 11.6 4.5 7.2 11.6 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-ZPR1 PF03367.13 EDO06773.1 - 1.2e-84 282.0 0.0 1.7e-41 141.7 0.0 2.1 2 0 0 2 2 2 2 ZPR1 zinc-finger domain Zn-ribbon_8 PF09723.10 EDO06773.1 - 0.0011 19.1 3.1 14 5.9 0.0 4.2 4 0 0 4 4 4 0 Zinc ribbon domain zinc_ribbon_4 PF13717.6 EDO06773.1 - 0.0072 16.2 3.9 6.8 6.7 0.3 3.5 3 0 0 3 3 3 1 zinc-ribbon domain HypA PF01155.19 EDO06773.1 - 0.0073 16.3 2.1 2.8 8.0 0.4 2.5 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-H2C2_2 PF13465.6 EDO06773.1 - 0.035 14.5 2.1 11 6.6 0.1 3.4 3 0 0 3 3 3 0 Zinc-finger double domain OrfB_Zn_ribbon PF07282.11 EDO06773.1 - 0.075 13.0 4.7 6.7 6.7 0.0 3.1 2 1 1 3 3 3 0 Putative transposase DNA-binding domain zf-RING_7 PF02591.15 EDO06773.1 - 0.078 13.2 4.3 31 4.8 0.0 4.3 4 0 0 4 4 4 0 C4-type zinc ribbon domain zf-AN1 PF01428.16 EDO06773.1 - 0.19 12.0 5.7 11 6.3 0.0 3.4 3 0 0 3 3 3 0 AN1-like Zinc finger RNHCP PF12647.7 EDO06773.1 - 0.32 11.0 3.1 3.1 7.8 0.0 3.2 3 1 0 3 3 3 0 RNHCP domain DZR PF12773.7 EDO06773.1 - 0.68 10.0 8.8 3.5 7.7 0.2 3.4 2 2 1 3 3 3 0 Double zinc ribbon Zn_Tnp_IS1595 PF12760.7 EDO06773.1 - 0.72 9.9 6.7 25 5.0 0.0 3.0 2 1 1 3 3 3 0 Transposase zinc-ribbon domain zf-ribbon_3 PF13248.6 EDO06773.1 - 1.1 8.7 13.6 9 5.9 0.7 4.3 4 0 0 4 4 4 0 zinc-ribbon domain zf-Mss51 PF13824.6 EDO06773.1 - 1.7 8.8 8.1 15 5.8 0.1 3.2 3 1 0 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 Rubredoxin_2 PF18073.1 EDO06773.1 - 3.9 7.3 12.3 7.5 6.4 0.2 4.1 4 0 0 4 4 4 0 Rubredoxin metal binding domain Sgf11 PF08209.11 EDO06773.1 - 5.5 6.6 5.3 18 5.0 0.1 3.1 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) RNA_POL_M_15KD PF02150.16 EDO06773.1 - 8 6.4 6.3 10 6.1 0.0 3.4 4 0 0 4 4 4 0 RNA polymerases M/15 Kd subunit zinc_ribbon_2 PF13240.6 EDO06773.1 - 9.9 6.0 18.3 15 5.5 0.4 4.3 4 0 0 4 4 4 0 zinc-ribbon domain DUF2428 PF10350.9 EDO06774.1 - 1.5e-21 76.9 0.1 4.2e-21 75.4 0.1 1.8 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT_2 PF13646.6 EDO06774.1 - 0.14 12.5 0.2 2.7 8.4 0.0 3.1 2 0 0 2 2 2 0 HEAT repeats RRM_1 PF00076.22 EDO06776.1 - 2.9e-18 65.4 0.3 4.1e-18 65.0 0.3 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDO06776.1 - 0.00069 19.2 0.0 0.0008 19.0 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDO06776.1 - 0.0017 18.1 0.0 0.0033 17.3 0.0 1.4 1 1 0 1 1 1 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EDO06776.1 - 0.017 15.1 0.0 0.027 14.5 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif AMPK1_CBM PF16561.5 EDO06777.1 - 2.8e-10 40.3 0.0 5.1e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase Cactin_mid PF10312.9 EDO06777.1 - 0.18 11.5 0.0 0.25 11.0 0.0 1.1 1 0 0 1 1 1 0 Conserved mid region of cactin TB2_DP1_HVA22 PF03134.19 EDO06778.1 - 4.5e-09 36.1 7.6 4.8e-09 36.0 6.9 1.5 1 1 0 1 1 1 1 TB2/DP1, HVA22 family eIF2_C PF09173.11 EDO06780.1 - 7.4e-35 119.1 0.2 2.3e-34 117.5 0.0 2.0 2 0 0 2 2 2 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 EDO06780.1 - 7.1e-24 84.4 0.1 5.3e-23 81.6 0.1 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EDO06780.1 - 2.8e-11 43.6 3.1 3.4e-11 43.4 0.7 2.4 2 1 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDO06780.1 - 0.0016 18.5 0.0 0.003 17.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDO06780.1 - 0.014 15.3 0.7 0.17 11.7 0.1 2.2 2 0 0 2 2 2 0 RsgA GTPase DUF1098 PF06497.11 EDO06780.1 - 0.3 11.6 1.3 0.4 11.2 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1098) FXMRP1_C_core PF12235.8 EDO06782.1 - 1.7 9.3 16.9 4.3 8.0 16.9 1.6 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal TRAPP PF04051.16 EDO06783.1 - 1.7e-28 99.2 0.1 2e-28 98.9 0.1 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component TSCPD PF12637.7 EDO06783.1 - 0.028 14.7 0.1 0.22 11.8 0.1 2.1 2 0 0 2 2 2 0 TSCPD domain Acetyltransf_CG PF14542.6 EDO06783.1 - 0.15 12.2 0.0 1.1 9.4 0.0 2.1 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase NOB1_Zn_bind PF08772.11 EDO06784.1 - 3.8e-20 71.8 0.1 7.6e-20 70.8 0.1 1.6 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 EDO06784.1 - 2.2e-16 60.1 0.0 5.6e-16 58.8 0.0 1.8 1 0 0 1 1 1 1 PIN domain of ribonuclease DUF2321 PF10083.9 EDO06784.1 - 0.00038 20.1 0.0 0.00068 19.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2321) Nudix_N_2 PF14803.6 EDO06784.1 - 0.18 11.7 1.5 0.31 11.0 0.1 2.1 2 0 0 2 2 2 0 Nudix N-terminal MOLO1 PF17175.4 EDO06785.1 - 6.3e-27 94.1 0.0 1.1e-26 93.3 0.0 1.4 1 0 0 1 1 1 1 Modulator of levamisole receptor-1 TPM_phosphatase PF04536.14 EDO06785.1 - 0.00015 21.9 0.0 0.00054 20.1 0.0 1.8 1 1 0 1 1 1 1 TPM domain UPF0054 PF02130.17 EDO06786.1 - 6.7e-21 74.4 0.7 9.1e-21 74.0 0.7 1.2 1 0 0 1 1 1 1 Uncharacterized protein family UPF0054 DUF3591 PF12157.8 EDO06787.1 - 2.4e-42 145.1 0.0 6.5e-42 143.7 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF3591) Bromodomain PF00439.25 EDO06787.1 - 2.4e-12 46.8 1.6 8.4e-12 45.0 0.2 2.5 2 0 0 2 2 2 1 Bromodomain zf-CCHC_6 PF15288.6 EDO06787.1 - 0.0028 17.4 1.4 0.0086 15.9 1.4 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 EDO06787.1 - 0.016 15.2 0.5 0.035 14.2 0.5 1.6 1 0 0 1 1 1 0 Zinc knuckle RPN5_C PF18098.1 EDO06787.1 - 0.033 14.3 0.1 0.33 11.1 0.0 2.6 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN5 C-terminal domain DUF2407 PF10302.9 EDO06787.1 - 0.051 14.1 0.1 0.16 12.5 0.1 1.9 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain EMP24_GP25L PF01105.24 EDO06788.1 - 9.7e-25 87.6 0.7 1.7e-24 86.8 0.1 1.7 2 0 0 2 2 2 1 emp24/gp25L/p24 family/GOLD ACDC PF14733.6 EDO06789.1 - 0.16 12.3 1.4 0.79 10.1 0.5 2.5 2 0 0 2 2 2 0 AP2-coincident C-terminal Tubulin PF00091.25 EDO06790.1 - 6.7e-61 205.9 0.0 9.2e-61 205.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EDO06790.1 - 4.8e-46 156.0 0.0 9.3e-46 155.1 0.0 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain DUF2456 PF10445.9 EDO06791.1 - 0.024 14.7 0.9 0.035 14.2 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2456) Glutaredoxin PF00462.24 EDO06793.1 - 1.6e-15 57.0 0.0 3.4e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.6 EDO06793.1 - 0.0016 18.5 0.0 0.0026 17.8 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin domain Thioredoxin_2 PF13098.6 EDO06793.1 - 0.0019 18.6 0.0 0.0022 18.5 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_4 PF13462.6 EDO06793.1 - 0.056 13.6 0.1 4.7 7.3 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin DUF836 PF05768.14 EDO06793.1 - 0.072 13.5 0.0 0.093 13.2 0.0 1.4 1 1 0 1 1 1 0 Glutaredoxin-like domain (DUF836) TraF PF13728.6 EDO06793.1 - 0.22 11.3 0.0 0.28 11.0 0.0 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein PDZ_3 PF17815.1 EDO06794.1 - 3.2e-44 150.3 0.0 5.4e-44 149.6 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Trypsin_2 PF13365.6 EDO06794.1 - 5e-19 69.7 0.4 9.5e-19 68.8 0.4 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EDO06794.1 - 1.6e-18 67.4 0.1 2.6e-18 66.6 0.1 1.3 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.6 EDO06794.1 - 1.2e-05 25.6 0.1 0.00013 22.2 0.1 2.4 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 EDO06794.1 - 1.2e-05 25.0 0.1 0.053 13.4 0.1 2.7 2 0 0 2 2 2 2 PDZ domain Peptidase_S46 PF10459.9 EDO06794.1 - 0.34 9.5 0.2 2 7.0 0.0 2.0 2 0 0 2 2 2 0 Peptidase S46 Ribosomal_L10 PF00466.20 EDO06795.1 - 5.4e-07 29.7 0.0 1.4e-06 28.4 0.0 1.7 1 1 0 1 1 1 1 Ribosomal protein L10 DEK_C PF08766.11 EDO06795.1 - 0.5 10.3 2.0 0.7 9.9 0.2 2.0 2 0 0 2 2 2 0 DEK C terminal domain UCH PF00443.29 EDO06796.1 - 3.2e-45 154.6 0.5 6e-45 153.8 0.5 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 EDO06796.1 - 4.5e-17 61.6 0.0 1e-16 60.4 0.0 1.7 1 0 0 1 1 1 1 Variant UBP zinc finger zf-UBP PF02148.19 EDO06796.1 - 1.8e-12 47.4 1.5 8.7e-12 45.2 0.0 2.5 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.31 EDO06796.1 - 7.6e-10 38.5 2.5 3.4e-05 23.7 0.2 2.5 2 0 0 2 2 2 2 UBA/TS-N domain UCH_1 PF13423.6 EDO06796.1 - 3.4e-09 36.8 3.1 1.2e-08 35.0 3.1 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Adaptin_N PF01602.20 EDO06796.1 - 0.086 11.4 0.1 0.14 10.7 0.1 1.2 1 0 0 1 1 1 0 Adaptin N terminal region ubiquitin PF00240.23 EDO06797.1 - 0.0021 17.8 0.0 0.0044 16.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 EDO06797.1 - 0.036 14.5 0.0 0.078 13.4 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain RRM_1 PF00076.22 EDO06798.1 - 8.8e-17 60.7 0.1 3.5e-16 58.8 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) eIF3g PF12353.8 EDO06798.1 - 1.3e-07 32.0 1.6 2.5e-07 31.1 1.3 1.5 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G pXO2-72 PF17443.2 EDO06798.1 - 0.081 13.2 0.5 0.59 10.4 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized protein pXO2-72 Folate_rec PF03024.14 EDO06799.1 - 0.057 13.3 0.2 0.076 12.9 0.2 1.2 1 0 0 1 1 1 0 Folate receptor family Tad PF13400.6 EDO06799.1 - 0.17 12.2 0.0 0.32 11.3 0.0 1.4 1 0 0 1 1 1 0 Putative Flp pilus-assembly TadE/G-like ELM2 PF01448.24 EDO06800.1 - 0.00015 22.5 0.1 0.00034 21.3 0.1 1.6 1 0 0 1 1 1 1 ELM2 domain RolB_RolC PF02027.17 EDO06800.1 - 0.11 12.1 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 RolB/RolC glucosidase family DnaJ PF00226.31 EDO06802.1 - 7.8e-19 67.6 0.6 1.1e-18 67.1 0.6 1.2 1 0 0 1 1 1 1 DnaJ domain LRIF1 PF15741.5 EDO06802.1 - 0.0048 15.5 0.0 0.0059 15.2 0.0 1.0 1 0 0 1 1 1 1 Ligand-dependent nuclear receptor-interacting factor 1 TGase_elicitor PF16683.5 EDO06802.1 - 0.15 10.8 0.0 0.17 10.6 0.0 1.1 1 0 0 1 1 1 0 Transglutaminase elicitor RRM_1 PF00076.22 EDO06803.1 - 1.6e-05 24.6 0.0 0.0016 18.2 0.0 2.3 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) bPH_5 PF10882.8 EDO06803.1 - 0.029 14.4 0.0 0.07 13.2 0.0 1.6 1 0 0 1 1 1 0 Bacterial PH domain Nup35_RRM_2 PF14605.6 EDO06803.1 - 0.092 12.8 0.0 0.48 10.5 0.0 2.1 1 1 1 2 2 2 0 Nup53/35/40-type RNA recognition motif EXOSC1 PF10447.9 EDO06804.1 - 2.2e-09 37.9 0.0 0.00038 21.0 0.0 2.2 1 1 1 2 2 2 2 Exosome component EXOSC1/CSL4 S1 PF00575.23 EDO06804.1 - 0.041 14.2 0.0 0.23 11.8 0.0 2.0 1 1 0 1 1 1 0 S1 RNA binding domain TRAPPC9-Trs120 PF08626.11 EDO06805.1 - 0.0043 14.5 0.0 0.0073 13.7 0.0 1.2 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Rieske PF00355.26 EDO06807.1 - 9.3e-06 25.5 0.0 1.7e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 EDO06807.1 - 0.00032 20.6 0.0 0.00041 20.3 0.0 1.2 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Pkinase PF00069.25 EDO06808.1 - 5.7e-47 160.3 0.0 9.4e-47 159.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO06808.1 - 4.1e-21 75.4 0.0 1.1e-20 74.0 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EDO06808.1 - 0.0011 19.0 0.6 0.0045 16.9 0.6 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 EDO06808.1 - 0.0058 16.2 0.1 0.38 10.3 0.0 2.5 2 0 0 2 2 2 1 RIO1 family Pox_ser-thr_kin PF05445.11 EDO06808.1 - 0.033 13.1 0.0 0.051 12.5 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Transpeptidase PF00905.22 EDO06808.1 - 0.057 12.6 0.1 0.095 11.9 0.1 1.2 1 0 0 1 1 1 0 Penicillin binding protein transpeptidase domain NAD_Gly3P_dh_N PF01210.23 EDO06809.1 - 2.3e-42 144.6 0.2 5.5e-42 143.4 0.1 1.6 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 EDO06809.1 - 1.5e-41 142.0 0.4 2.7e-41 141.2 0.4 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 2-Hacid_dh_C PF02826.19 EDO06809.1 - 1.2e-05 24.7 0.1 0.065 12.6 0.0 2.3 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EDO06809.1 - 0.0081 15.7 1.2 3.8 7.1 0.0 3.8 4 0 0 4 4 4 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain F420_oxidored PF03807.17 EDO06809.1 - 0.06 13.9 0.0 1.9 9.1 0.0 2.6 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent U-box PF04564.15 EDO06810.1 - 3.7e-25 87.9 0.2 9e-25 86.6 0.0 1.8 2 0 0 2 2 2 1 U-box domain TPR_2 PF07719.17 EDO06810.1 - 8.8e-17 59.8 3.6 6.8e-05 22.7 0.1 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 EDO06810.1 - 6.2e-16 57.5 4.7 1.1e-05 25.0 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EDO06810.1 - 1.5e-15 56.6 4.2 6.7e-10 38.5 0.3 2.6 1 1 1 2 2 2 2 TPR repeat TPR_17 PF13431.6 EDO06810.1 - 1e-09 38.1 1.4 6e-05 23.2 0.4 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO06810.1 - 3.1e-09 36.9 0.8 6.2e-09 36.0 0.8 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EDO06810.1 - 3.6e-09 37.1 0.0 0.001 19.7 0.0 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDO06810.1 - 2.2e-07 30.6 2.6 0.0093 16.1 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDO06810.1 - 8.1e-06 26.3 0.2 0.19 12.2 0.1 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDO06810.1 - 2.7e-05 24.6 0.0 0.6 11.1 0.0 2.9 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDO06810.1 - 7.8e-05 22.9 0.1 0.061 13.6 0.0 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 EDO06810.1 - 0.00022 21.3 0.0 0.024 14.8 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat NARP1 PF12569.8 EDO06810.1 - 0.00034 19.7 0.0 0.00048 19.2 0.0 1.3 1 0 0 1 1 1 1 NMDA receptor-regulated protein 1 TPR_15 PF13429.6 EDO06810.1 - 0.00038 19.8 0.2 0.00056 19.2 0.2 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat zf-NOSIP PF15906.5 EDO06810.1 - 0.00052 20.1 0.1 0.0014 18.7 0.1 1.7 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein TPR_6 PF13174.6 EDO06810.1 - 0.0052 17.3 1.8 9.1 7.2 0.1 3.7 4 0 0 4 4 3 1 Tetratricopeptide repeat FAT PF02259.23 EDO06810.1 - 0.052 12.8 0.6 0.089 12.0 0.6 1.5 1 1 0 1 1 1 0 FAT domain TPR_7 PF13176.6 EDO06810.1 - 0.054 13.5 0.2 55 4.1 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat GTP1_OBG PF01018.22 EDO06811.1 - 2e-34 118.4 2.9 6.6e-34 116.7 2.8 1.7 2 0 0 2 2 2 1 GTP1/OBG MMR_HSR1 PF01926.23 EDO06812.1 - 2.9e-19 69.2 0.1 5.5e-09 36.1 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase DUF1967 PF09269.11 EDO06812.1 - 7.6e-14 51.4 0.1 1.8e-13 50.2 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1967) GTP1_OBG PF01018.22 EDO06812.1 - 3.3e-07 30.0 0.1 5.1e-07 29.4 0.1 1.3 1 0 0 1 1 1 1 GTP1/OBG FeoB_N PF02421.18 EDO06812.1 - 1.7e-05 24.4 0.6 0.0019 17.7 0.0 2.4 2 1 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EDO06812.1 - 4.3e-05 23.6 0.2 0.00053 20.1 0.2 2.2 1 1 0 1 1 1 1 Dynamin family Gtr1_RagA PF04670.12 EDO06812.1 - 0.00025 20.5 0.1 0.0034 16.8 0.1 2.1 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region cobW PF02492.19 EDO06812.1 - 0.0023 17.5 0.1 0.013 15.1 0.1 2.0 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1_Xtn PF16897.5 EDO06812.1 - 0.0023 17.9 0.4 0.0055 16.7 0.4 1.6 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain RsgA_GTPase PF03193.16 EDO06812.1 - 0.0071 16.3 0.6 0.31 10.9 0.2 2.5 3 0 0 3 3 3 1 RsgA GTPase Arf PF00025.21 EDO06812.1 - 0.0095 15.4 0.2 0.036 13.5 0.1 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_18 PF13238.6 EDO06812.1 - 0.018 15.6 0.0 0.078 13.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 EDO06812.1 - 0.037 13.8 0.1 1.6 8.5 0.1 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_21 PF13304.6 EDO06812.1 - 0.039 13.7 0.6 0.09 12.6 0.0 2.0 2 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system ssDNA-exonuc_C PF10141.9 EDO06812.1 - 0.072 12.7 0.1 0.19 11.3 0.1 1.6 1 0 0 1 1 1 0 Single-strand DNA-specific exonuclease, C terminal domain AAA_15 PF13175.6 EDO06812.1 - 0.84 9.3 9.4 1.1 8.9 8.7 1.7 1 1 0 1 1 1 0 AAA ATPase domain EF-hand_1 PF00036.32 EDO06813.1 - 8.8e-07 28.0 0.1 0.00012 21.4 0.0 3.4 4 0 0 4 4 4 1 EF hand EF-hand_6 PF13405.6 EDO06813.1 - 2.5e-06 27.0 0.0 0.095 12.7 0.0 3.5 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 EDO06813.1 - 1.4e-05 24.9 0.0 4.4e-05 23.2 0.0 1.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.6 EDO06813.1 - 1.8e-05 25.1 0.0 5.3e-05 23.6 0.0 1.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_9 PF14658.6 EDO06813.1 - 0.0098 16.2 0.0 0.55 10.6 0.0 2.6 2 1 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 EDO06813.1 - 0.13 11.8 0.5 0.88 9.2 0.0 2.6 3 0 0 3 3 3 0 EF hand Tup_N PF08581.10 EDO06814.1 - 0.0054 17.0 3.7 0.0054 17.0 3.7 3.9 5 0 0 5 5 5 1 Tup N-terminal Fez1 PF06818.15 EDO06814.1 - 0.18 12.3 33.0 0.11 12.9 8.2 3.7 2 2 1 3 3 3 0 Fez1 Phage_GP20 PF06810.11 EDO06814.1 - 0.29 10.9 0.1 0.29 10.9 0.1 4.7 4 1 1 6 6 6 0 Phage minor structural protein GP20 FliD_N PF02465.18 EDO06814.1 - 0.73 10.6 3.1 1.7 9.4 0.2 2.9 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus ATG16 PF08614.11 EDO06814.1 - 1 9.5 34.3 3.7 7.7 0.3 4.6 3 1 1 4 4 4 0 Autophagy protein 16 (ATG16) DUF4047 PF13256.6 EDO06814.1 - 1.8 8.8 7.6 0.2 11.9 0.5 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4047) Hrs_helical PF12210.8 EDO06814.1 - 3.8 8.1 11.7 13 6.4 0.0 4.3 4 0 0 4 4 4 0 Hepatocyte growth factor-regulated tyrosine kinase substrate ZnuA PF01297.17 EDO06814.1 - 6.7 6.0 10.0 0.79 9.1 0.0 2.9 1 1 1 3 3 3 0 Zinc-uptake complex component A periplasmic Fzo_mitofusin PF04799.13 EDO06814.1 - 9.8 5.7 16.2 2.9 7.4 0.3 4.6 3 2 1 5 5 5 0 fzo-like conserved region RL10P_insert PF17777.1 EDO06815.1 - 7.5e-20 70.7 0.1 1.2e-19 70.0 0.1 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 EDO06815.1 - 2.5e-18 66.1 0.0 5.2e-18 65.0 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.19 EDO06815.1 - 7.9e-17 61.6 1.4 7.9e-17 61.6 1.4 2.1 2 0 0 2 2 2 1 60s Acidic ribosomal protein Ribosomal_L38e PF01781.18 EDO06816.1 - 1.8e-22 79.2 0.2 2e-22 79.0 0.2 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family HAGH_C PF16123.5 EDO06817.1 - 5.8e-24 84.4 0.1 9.7e-24 83.7 0.1 1.4 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 EDO06817.1 - 4.6e-08 33.3 0.3 1.1e-07 32.1 0.3 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EDO06817.1 - 0.0031 17.0 0.1 0.0092 15.5 0.0 1.9 1 1 0 1 1 1 1 Beta-lactamase superfamily domain DUF2981 PF11200.8 EDO06818.1 - 5.5e-167 555.6 0.3 6.1e-167 555.5 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2981) Tetraspanin PF00335.20 EDO06818.1 - 0.044 13.5 2.8 0.08 12.6 2.8 1.4 1 0 0 1 1 1 0 Tetraspanin family AAA PF00004.29 EDO06819.1 - 4.8e-42 143.5 0.0 9.4e-42 142.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EDO06819.1 - 5.3e-19 67.9 0.3 1.1e-18 67.0 0.3 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EDO06819.1 - 1.7e-13 50.1 0.2 3.9e-13 49.0 0.2 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EDO06819.1 - 1.8e-07 31.3 0.1 1e-06 28.8 0.0 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDO06819.1 - 3.5e-06 27.5 0.1 0.0012 19.2 0.0 2.5 1 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EDO06819.1 - 3.2e-05 23.7 0.0 0.0001 22.1 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EDO06819.1 - 4.2e-05 23.7 0.0 0.00015 21.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EDO06819.1 - 0.00038 20.7 0.0 0.00069 19.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDO06819.1 - 0.00042 20.6 0.9 0.05 13.9 0.1 2.6 1 1 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EDO06819.1 - 0.0014 18.0 0.3 0.028 13.8 0.1 2.7 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI PhoH PF02562.16 EDO06819.1 - 0.015 14.8 0.0 0.033 13.7 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Sigma54_activat PF00158.26 EDO06819.1 - 0.026 14.3 0.1 0.13 11.9 0.1 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_14 PF13173.6 EDO06819.1 - 0.027 14.5 0.0 0.064 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EDO06819.1 - 0.027 14.2 0.0 0.049 13.3 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 EDO06819.1 - 0.078 12.2 1.3 0.078 12.2 0.0 1.6 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_7 PF12775.7 EDO06819.1 - 0.093 12.2 0.1 0.27 10.7 0.1 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_11 PF13086.6 EDO06819.1 - 0.094 12.5 0.1 0.094 12.5 0.1 2.0 2 1 0 2 2 2 0 AAA domain AAA_3 PF07726.11 EDO06819.1 - 0.1 12.4 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EDO06819.1 - 0.12 11.7 0.5 0.26 10.5 0.1 1.8 2 0 0 2 2 2 0 Zeta toxin TsaE PF02367.17 EDO06819.1 - 0.15 12.1 0.0 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 EDO06819.1 - 0.24 11.1 1.5 0.48 10.1 0.2 2.2 2 1 0 2 2 2 0 AAA domain ATPase PF06745.13 EDO06819.1 - 0.25 10.6 0.0 0.25 10.6 0.0 2.2 3 0 0 3 3 3 0 KaiC DUF3510 PF12022.8 EDO06820.1 - 1.3e-17 64.4 1.1 1.3e-17 64.4 1.1 3.7 3 2 1 4 4 4 1 Domain of unknown function (DUF3510) TLE_N PF03920.15 EDO06820.1 - 0.048 13.8 5.7 0.22 11.6 0.9 3.4 3 0 0 3 3 3 0 Groucho/TLE N-terminal Q-rich domain DUF1993 PF09351.10 EDO06820.1 - 2.6 8.2 6.1 2.8 8.0 0.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1993) KNOX2 PF03791.13 EDO06820.1 - 5.8 6.5 5.7 32 4.1 0.3 3.2 3 0 0 3 3 3 0 KNOX2 domain Ufm1 PF03671.14 EDO06821.1 - 2.2e-26 91.7 0.0 2.2e-26 91.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fold modifier 1 protein CXCXC PF03128.14 EDO06821.1 - 0.14 12.7 1.0 0.3 11.6 0.1 2.1 2 0 0 2 2 2 0 CXCXC repeat SMC_N PF02463.19 EDO06822.1 - 9.1e-56 188.7 0.0 2.7e-55 187.2 0.0 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EDO06822.1 - 6.4e-18 65.2 0.1 4.2e-17 62.5 0.0 2.5 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EDO06822.1 - 4.5e-14 52.9 4.5 3e-07 30.6 0.1 3.3 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EDO06822.1 - 1.8e-10 41.1 3.4 1.8e-10 41.1 3.4 3.7 2 2 1 3 3 2 1 AAA ATPase domain AAA_23 PF13476.6 EDO06822.1 - 9.4e-09 36.1 19.7 9.4e-09 36.1 19.7 5.8 2 2 2 4 4 3 1 AAA domain AAA_29 PF13555.6 EDO06822.1 - 3e-08 33.3 0.1 7.1e-08 32.1 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain KASH_CCD PF14662.6 EDO06822.1 - 0.00053 19.9 12.9 0.00053 19.9 12.9 7.0 4 2 2 7 7 6 1 Coiled-coil region of CCDC155 or KASH SbcCD_C PF13558.6 EDO06822.1 - 0.02 15.1 0.1 0.05 13.9 0.1 1.7 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.6 EDO06822.1 - 0.032 14.5 5.0 4.6 7.5 0.0 4.3 4 0 0 4 4 4 0 AAA domain ABC_tran PF00005.27 EDO06822.1 - 0.044 14.3 0.0 0.044 14.3 0.0 4.8 4 1 0 4 4 3 0 ABC transporter AAA_24 PF13479.6 EDO06822.1 - 0.13 12.0 1.2 10 5.8 0.1 3.0 3 0 0 3 3 3 0 AAA domain GAS PF13851.6 EDO06822.1 - 0.5 9.7 80.6 0.37 10.1 0.0 7.1 4 1 1 5 5 5 0 Growth-arrest specific micro-tubule binding DUF1664 PF07889.12 EDO06822.1 - 0.68 10.0 47.9 1.2 9.1 0.0 8.0 5 1 2 8 8 8 0 Protein of unknown function (DUF1664) DUF3896 PF13035.6 EDO06822.1 - 3.6 7.8 6.2 2 8.6 1.2 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3896) Spc7 PF08317.11 EDO06822.1 - 3.8 6.3 85.8 0.12 11.3 0.1 6.7 4 2 4 8 8 8 0 Spc7 kinetochore protein RRM_1 PF00076.22 EDO06823.1 - 4.7e-21 74.4 0.0 3.4e-09 36.4 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Importin_rep_4 PF18808.1 EDO06826.1 - 8.5e-13 48.4 0.4 9.2e-12 45.1 0.2 3.0 3 0 0 3 3 1 1 Importin repeat HEAT_2 PF13646.6 EDO06826.1 - 1.6e-12 47.6 0.9 0.0011 19.3 0.0 7.7 5 5 4 9 9 9 2 HEAT repeats HEAT PF02985.22 EDO06826.1 - 3.3e-12 45.5 7.4 0.037 14.3 0.0 9.2 12 0 0 12 12 9 3 HEAT repeat HEAT_EZ PF13513.6 EDO06826.1 - 2.2e-10 40.8 0.0 3.7e-05 24.1 0.0 6.6 7 0 0 7 7 5 1 HEAT-like repeat Cnd1 PF12717.7 EDO06826.1 - 4.2e-09 36.6 14.0 0.0011 19.0 0.2 5.7 5 1 0 5 5 5 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EDO06826.1 - 6.2e-09 36.3 9.8 0.0051 17.4 0.1 6.7 5 2 2 7 7 7 2 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EDO06826.1 - 1.9e-07 30.9 10.1 0.34 10.4 0.0 6.8 7 2 1 8 8 8 3 CLASP N terminal Adaptin_N PF01602.20 EDO06826.1 - 1.2e-06 27.5 6.4 0.15 10.6 0.0 5.6 5 2 0 5 5 5 2 Adaptin N terminal region DUF3385 PF11865.8 EDO06826.1 - 1.5e-06 28.3 9.2 0.71 9.8 0.0 6.1 5 1 1 7 7 7 3 Domain of unknown function (DUF3385) Tti2 PF10521.9 EDO06826.1 - 0.00091 18.9 4.1 7.2 6.1 0.3 6.5 5 1 0 5 5 5 1 Tti2 family IFRD PF05004.13 EDO06826.1 - 0.0098 15.0 6.0 0.061 12.4 0.1 3.8 3 1 1 4 4 4 1 Interferon-related developmental regulator (IFRD) RTP1_C1 PF10363.9 EDO06826.1 - 0.014 15.6 2.3 1.2 9.3 0.0 4.8 5 2 1 6 6 4 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF4042 PF13251.6 EDO06826.1 - 0.02 14.6 2.0 11 5.6 0.0 4.1 4 1 0 4 4 4 0 Domain of unknown function (DUF4042) Arm PF00514.23 EDO06826.1 - 0.045 13.8 0.0 53 4.1 0.0 4.5 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat UME PF08064.13 EDO06826.1 - 0.82 9.6 13.7 15 5.6 0.3 7.0 5 2 3 8 8 8 0 UME (NUC010) domain MIF4G PF02854.19 EDO06826.1 - 2.1 7.9 10.9 18 4.8 0.2 5.1 4 2 0 4 4 4 0 MIF4G domain SSPI PF14098.6 EDO06827.1 - 0.092 12.9 0.2 0.59 10.3 0.2 2.1 2 0 0 2 2 2 0 Small, acid-soluble spore protein I SET PF00856.28 EDO06829.1 - 6.8e-15 55.9 0.7 4.8e-14 53.1 0.0 2.8 3 1 0 3 3 3 1 SET domain Arc_C PF18162.1 EDO06830.1 - 0.013 15.4 0.0 0.021 14.6 0.0 1.3 1 0 0 1 1 1 0 Arc C-lobe TFIID_30kDa PF03540.13 EDO06830.1 - 0.018 14.9 0.0 0.027 14.4 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID 23-30kDa subunit MMR_HSR1_Xtn PF16897.5 EDO06831.1 - 1e-42 144.5 0.4 1.7e-42 143.7 0.4 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 EDO06831.1 - 2e-22 79.4 0.0 5.8e-22 77.9 0.0 1.8 1 1 1 2 2 2 1 50S ribosome-binding GTPase TGS PF02824.21 EDO06831.1 - 5.1e-22 77.7 0.1 9.4e-22 76.8 0.1 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EDO06831.1 - 7.1e-13 48.4 0.1 2e-12 46.9 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EDO06831.1 - 2.9e-06 27.5 0.1 0.028 14.5 0.0 2.5 1 1 1 2 2 2 2 Dynamin family MeaB PF03308.16 EDO06831.1 - 0.0015 17.6 0.2 0.0042 16.1 0.1 1.8 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 EDO06831.1 - 0.0079 15.7 0.4 35 3.9 0.0 4.0 2 2 2 4 4 4 0 Elongation factor Tu GTP binding domain AIG1 PF04548.16 EDO06831.1 - 0.012 15.0 0.1 0.017 14.5 0.1 1.3 1 0 0 1 1 1 0 AIG1 family SRPRB PF09439.10 EDO06831.1 - 0.045 13.2 0.0 0.1 12.1 0.0 1.5 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EDO06831.1 - 0.11 12.4 0.3 0.48 10.3 0.1 2.1 2 0 0 2 2 2 0 RsgA GTPase ABC_tran PF00005.27 EDO06831.1 - 0.11 13.0 0.0 0.25 11.8 0.0 1.5 1 0 0 1 1 1 0 ABC transporter GTP_EFTU PF00009.27 EDO06832.1 - 3e-61 206.4 0.0 4.6e-61 205.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EDO06832.1 - 4.4e-40 136.2 0.0 9e-40 135.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 EDO06832.1 - 2.6e-29 101.1 0.0 5.6e-29 100.1 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EDO06832.1 - 9.2e-25 86.5 0.0 1.8e-24 85.6 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EDO06832.1 - 1.9e-16 60.2 0.2 4e-16 59.2 0.2 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EDO06832.1 - 0.00021 21.1 0.0 0.00045 20.0 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 EDO06832.1 - 0.11 12.6 0.0 0.24 11.5 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase zf-MYND PF01753.18 EDO06833.1 - 7e-11 42.0 15.5 1.5e-10 41.0 15.5 1.6 1 0 0 1 1 1 1 MYND finger TCTP PF00838.17 EDO06834.1 - 7.2e-54 182.6 0.4 8.1e-54 182.4 0.4 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein Tma16 PF11176.8 EDO06834.1 - 0.2 11.5 0.0 0.3 11.0 0.0 1.3 1 0 0 1 1 1 0 Translation machinery-associated protein 16 Avl9 PF09794.9 EDO06835.1 - 3.6e-27 95.0 3.1 3e-23 82.1 2.3 3.3 2 1 0 2 2 2 2 Transport protein Avl9 MORN PF02493.20 EDO06835.1 - 2.9e-24 83.5 39.4 0.0001 22.0 1.6 10.6 11 0 0 11 11 11 8 MORN repeat SPA PF08616.10 EDO06835.1 - 0.13 12.3 0.2 0.56 10.2 0.2 2.0 1 1 0 1 1 1 0 Stabilization of polarity axis DENN PF02141.21 EDO06835.1 - 0.15 12.0 2.5 10 6.0 0.3 2.6 2 0 0 2 2 2 0 DENN (AEX-3) domain CGI-121 PF08617.10 EDO06836.1 - 1.1e-14 54.9 0.9 2.5e-09 37.5 0.7 2.1 1 1 1 2 2 2 2 Kinase binding protein CGI-121 DUF416 PF04222.12 EDO06836.1 - 0.082 12.3 1.2 0.25 10.7 1.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF416) Pox_H7 PF04787.12 EDO06838.1 - 0.18 12.3 0.3 0.32 11.5 0.3 1.4 1 0 0 1 1 1 0 Late protein H7 Dus PF01207.17 EDO06839.1 - 4.4e-70 236.2 0.0 5.5e-70 235.9 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 EDO06839.1 - 2.3e-05 24.0 0.0 3.5e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Histidine biosynthesis protein ThiG PF05690.14 EDO06839.1 - 4e-05 23.0 0.0 6e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG G3P_antiterm PF04309.12 EDO06839.1 - 0.0029 17.1 0.0 0.0065 15.9 0.0 1.5 2 0 0 2 2 2 1 Glycerol-3-phosphate responsive antiterminator IMPDH PF00478.25 EDO06839.1 - 0.016 14.2 0.0 0.026 13.5 0.0 1.2 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EDO06839.1 - 0.027 13.9 0.0 0.037 13.4 0.0 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase DHO_dh PF01180.21 EDO06839.1 - 0.22 10.7 0.0 0.81 8.8 0.0 1.9 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase Prefoldin_2 PF01920.20 EDO06841.1 - 1.1e-14 54.3 3.2 1.3e-14 54.1 3.2 1.1 1 0 0 1 1 1 1 Prefoldin subunit Spc7 PF08317.11 EDO06841.1 - 0.0013 17.7 2.8 0.0015 17.4 2.8 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein MADF_DNA_bdg PF10545.9 EDO06841.1 - 0.0028 17.9 0.0 1.1 9.6 0.0 2.1 2 0 0 2 2 2 2 Alcohol dehydrogenase transcription factor Myb/SANT-like ING PF12998.7 EDO06841.1 - 0.0034 17.9 3.2 0.0052 17.3 3.2 1.4 1 1 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding Scaffolding_pro PF11418.8 EDO06841.1 - 0.0039 17.7 0.4 0.0081 16.7 0.2 1.6 1 1 0 1 1 1 1 Phi29 scaffolding protein Lebercilin PF15619.6 EDO06841.1 - 0.0057 16.3 1.1 0.007 16.1 1.1 1.1 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease DUF948 PF06103.11 EDO06841.1 - 0.0088 16.3 2.2 0.15 12.4 0.1 2.1 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF948) FapA PF03961.13 EDO06841.1 - 0.022 13.4 2.4 0.025 13.2 2.4 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Prefoldin_3 PF13758.6 EDO06841.1 - 0.032 14.3 1.1 0.11 12.6 1.1 1.8 1 1 0 1 1 1 0 Prefoldin subunit Seryl_tRNA_N PF02403.22 EDO06841.1 - 0.1 12.9 3.5 1.1 9.5 3.5 2.0 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain MerR-DNA-bind PF09278.11 EDO06841.1 - 0.13 12.9 0.2 9.1 6.9 0.0 2.3 2 0 0 2 2 2 0 MerR, DNA binding pRN1_helical PF13010.6 EDO06841.1 - 0.13 12.2 0.6 0.22 11.5 0.6 1.4 1 1 0 1 1 1 0 Primase helical domain NPV_P10 PF05531.12 EDO06841.1 - 0.16 12.5 2.5 16 6.1 2.5 2.1 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF4201 PF13870.6 EDO06841.1 - 0.16 11.7 5.0 3.3 7.4 0.2 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4201) Prefoldin PF02996.17 EDO06841.1 - 0.2 11.6 5.3 0.54 10.2 1.0 2.2 2 0 0 2 2 2 0 Prefoldin subunit DUF1664 PF07889.12 EDO06841.1 - 0.23 11.5 2.6 0.41 10.7 0.5 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) PI3K_P85_iSH2 PF16454.5 EDO06841.1 - 0.25 10.9 4.4 2.5 7.7 4.4 1.9 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Snapin_Pallidin PF14712.6 EDO06841.1 - 0.34 11.4 4.3 2.5 8.6 2.7 2.1 1 1 1 2 2 2 0 Snapin/Pallidin TPR_MLP1_2 PF07926.12 EDO06841.1 - 0.7 10.0 6.9 7 6.7 1.0 2.0 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein TMPIT PF07851.13 EDO06841.1 - 1.2 8.4 4.3 1.6 7.9 4.3 1.3 1 1 0 1 1 1 0 TMPIT-like protein Gal_Lectin PF02140.18 EDO06842.1 - 0.0063 16.9 7.0 25 5.4 2.5 4.7 5 0 0 5 5 5 3 Galactose binding lectin domain M60-like_N PF17291.2 EDO06842.1 - 0.12 12.2 0.3 8.2 6.4 0.0 2.7 2 0 0 2 2 2 0 N-terminal domain of M60-like peptidases GSH_synth_ATP PF03917.17 EDO06843.1 - 2e-60 204.6 0.0 2.5e-60 204.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 EDO06843.1 - 9.1e-22 77.5 0.0 1.7e-21 76.6 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic glutathione synthase USP7_ICP0_bdg PF12436.8 EDO06844.1 - 0.015 14.6 0.0 0.029 13.7 0.0 1.4 1 0 0 1 1 1 0 ICP0-binding domain of Ubiquitin-specific protease 7 Na_trans_assoc PF06512.13 EDO06844.1 - 0.38 11.0 8.3 1.1 9.5 8.3 1.8 1 0 0 1 1 1 0 Sodium ion transport-associated 2-oxoacid_dh PF00198.23 EDO06845.1 - 5.6e-78 261.6 0.2 7.3e-78 261.2 0.2 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EDO06845.1 - 3.9e-17 61.8 1.9 8.3e-17 60.8 1.9 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme GCV_H PF01597.19 EDO06845.1 - 0.00089 19.1 0.3 0.0019 18.1 0.3 1.6 1 0 0 1 1 1 1 Glycine cleavage H-protein Nsp1_C PF05064.13 EDO06846.1 - 0.1 12.4 0.1 0.24 11.2 0.1 1.6 1 0 0 1 1 1 0 Nsp1-like C-terminal region ANAPC4_WD40 PF12894.7 EDO06847.1 - 0.0057 16.9 0.1 1.1 9.6 0.1 3.1 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Clathrin PF00637.20 EDO06847.1 - 0.0099 15.8 0.0 0.043 13.7 0.0 2.1 1 0 0 1 1 1 1 Region in Clathrin and VPS zf-RING_11 PF17123.5 EDO06847.1 - 0.073 12.8 0.6 0.76 9.6 0.3 3.0 2 0 0 2 2 2 0 RING-like zinc finger DUF2545 PF10810.8 EDO06847.1 - 0.17 12.0 1.1 0.49 10.6 1.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2545) Fz PF01392.22 EDO06850.1 - 0.13 12.9 0.5 0.24 12.0 0.5 1.4 1 0 0 1 1 1 0 Fz domain DUF3681 PF12442.8 EDO06851.1 - 0.12 12.9 1.6 0.19 12.2 1.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3681) ABC_membrane PF00664.23 EDO06852.1 - 2.8e-36 125.6 0.2 3.9e-36 125.1 0.2 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EDO06852.1 - 8.1e-30 104.1 0.0 1.3e-28 100.2 0.0 2.2 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 EDO06852.1 - 0.00012 21.6 0.0 0.031 13.7 0.0 2.4 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EDO06852.1 - 0.0016 18.7 0.2 0.033 14.5 0.2 2.4 1 1 0 1 1 1 1 AAA domain DUF87 PF01935.17 EDO06852.1 - 0.041 14.0 0.1 0.12 12.4 0.0 1.7 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_15 PF13175.6 EDO06852.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_16 PF13191.6 EDO06852.1 - 0.11 12.8 0.1 0.26 11.7 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain SRP54 PF00448.22 EDO06852.1 - 0.15 11.7 0.1 0.25 11.0 0.1 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Rgp1 PF08737.10 EDO06853.1 - 0.01 15.0 0.2 0.014 14.6 0.2 1.1 1 0 0 1 1 1 0 Rgp1 Laminin_G_3 PF13385.6 EDO06854.1 - 0.013 15.6 0.0 0.019 15.1 0.0 1.3 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily NAGLU_N PF12971.7 EDO06854.1 - 0.04 13.7 0.0 0.082 12.7 0.0 1.6 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain Thg1 PF04446.12 EDO06857.1 - 1.2e-34 119.0 0.1 1.5e-25 89.6 0.0 2.2 1 1 1 2 2 2 2 tRNAHis guanylyltransferase Thg1C PF14413.6 EDO06857.1 - 2.4e-32 111.7 0.1 3.6e-32 111.1 0.1 1.3 1 0 0 1 1 1 1 Thg1 C terminal domain DNA_pol3_beta_2 PF02767.16 EDO06857.1 - 0.035 14.3 0.0 0.075 13.3 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase III beta subunit, central domain MBOAT PF03062.19 EDO06858.1 - 1.4e-17 64.1 27.7 2.3e-17 63.4 27.7 1.4 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Fez1 PF06818.15 EDO06859.1 - 0.00024 21.6 11.3 0.00024 21.6 11.3 4.3 1 1 2 4 4 4 2 Fez1 APG6_N PF17675.1 EDO06859.1 - 0.00043 20.8 37.7 0.00092 19.8 16.7 5.1 2 2 2 5 5 5 2 Apg6 coiled-coil region Spc7 PF08317.11 EDO06859.1 - 0.0024 16.8 15.2 0.0024 16.8 15.2 4.2 2 1 2 4 4 4 2 Spc7 kinetochore protein JIP_LZII PF16471.5 EDO06859.1 - 0.0037 17.4 3.0 0.0037 17.4 3.0 6.7 2 2 5 8 8 8 1 JNK-interacting protein leucine zipper II GAS PF13851.6 EDO06859.1 - 0.0063 15.9 14.5 0.0063 15.9 14.5 4.7 3 1 1 5 5 5 2 Growth-arrest specific micro-tubule binding Sugarporin_N PF11471.8 EDO06859.1 - 0.063 13.2 13.0 4.9 7.2 0.1 4.7 4 0 0 4 4 4 0 Maltoporin periplasmic N-terminal extension PTAC PF06130.12 EDO06859.1 - 0.13 12.4 0.8 6.5 7.0 0.3 2.7 2 0 0 2 2 2 0 Phosphate propanoyltransferase WXG100 PF06013.12 EDO06859.1 - 0.14 12.4 0.4 0.14 12.4 0.4 6.2 3 2 2 6 6 6 0 Proteins of 100 residues with WXG CENP-F_leu_zip PF10473.9 EDO06859.1 - 0.24 11.4 53.9 2.3 8.2 24.0 5.2 2 1 3 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tropomyosin_1 PF12718.7 EDO06859.1 - 0.29 11.3 51.1 0.49 10.5 1.8 5.2 2 1 3 5 5 5 0 Tropomyosin like DUF4407 PF14362.6 EDO06859.1 - 0.33 10.3 32.1 0.32 10.3 15.8 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) ADIP PF11559.8 EDO06859.1 - 0.39 10.8 53.7 0.14 12.2 6.5 5.7 2 1 3 5 5 5 0 Afadin- and alpha -actinin-Binding Mce4_CUP1 PF11887.8 EDO06859.1 - 0.42 10.0 3.1 0.34 10.3 1.1 1.9 2 0 0 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative FlaC_arch PF05377.11 EDO06859.1 - 0.55 10.7 30.0 17 5.9 0.6 8.5 5 3 2 7 7 7 0 Flagella accessory protein C (FlaC) Bap31_Bap29_C PF18035.1 EDO06859.1 - 0.78 9.8 0.0 0.78 9.8 0.0 5.9 7 0 0 7 7 6 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF4472 PF14739.6 EDO06859.1 - 1.4 9.7 44.1 0.44 11.3 1.9 5.8 3 2 1 4 4 4 0 Domain of unknown function (DUF4472) Filament PF00038.21 EDO06859.1 - 1.6 8.3 48.2 0.067 12.8 11.2 4.5 2 1 1 4 4 4 0 Intermediate filament protein BLOC1_2 PF10046.9 EDO06859.1 - 1.9 8.9 34.6 1 9.7 4.6 7.0 6 1 2 8 8 7 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ATG16 PF08614.11 EDO06859.1 - 2.3 8.4 56.3 5.5 7.2 17.3 4.5 2 2 2 4 4 4 0 Autophagy protein 16 (ATG16) Golgin_A5 PF09787.9 EDO06859.1 - 2.5 7.5 55.2 1.3 8.4 14.1 4.3 2 2 2 4 4 4 0 Golgin subfamily A member 5 DUF948 PF06103.11 EDO06859.1 - 3.5 7.9 9.6 15 5.9 0.2 5.5 4 3 1 6 6 6 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 EDO06859.1 - 4.4 7.4 27.4 2.8 8.0 1.0 4.9 2 1 4 6 6 6 0 Protein of unknown function (DUF1664) DUF4201 PF13870.6 EDO06859.1 - 6.7 6.4 50.4 0.038 13.7 10.6 5.5 2 2 2 4 4 4 0 Domain of unknown function (DUF4201) mRNA_triPase PF02940.15 EDO06860.1 - 1.6e-40 139.2 0.0 2.1e-40 138.8 0.0 1.1 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain Pro_isomerase PF00160.21 EDO06861.1 - 6.9e-48 162.9 0.1 8.2e-48 162.7 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD CPSF_A PF03178.15 EDO06862.1 - 1.2e-34 120.1 0.3 2.1e-23 83.2 0.0 3.0 3 0 0 3 3 3 2 CPSF A subunit region MMS1_N PF10433.9 EDO06862.1 - 3.1e-15 55.8 0.0 2.2e-13 49.7 0.0 2.9 2 1 0 2 2 2 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term Utp21 PF04192.12 EDO06863.1 - 1.4e-31 109.8 0.0 2e-31 109.3 0.0 1.1 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain ANAPC4_WD40 PF12894.7 EDO06863.1 - 2.3e-10 40.6 0.1 0.08 13.2 0.0 5.9 4 3 2 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO06863.1 - 5.2e-07 30.3 10.0 0.00061 20.5 0.0 6.5 5 1 1 6 6 6 2 WD domain, G-beta repeat DUF4999 PF16390.5 EDO06863.1 - 0.13 12.5 0.6 0.54 10.5 0.1 2.3 2 1 1 3 3 3 0 Domain of unknown function Serpin PF00079.20 EDO06863.1 - 0.14 11.4 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Serpin (serine protease inhibitor) Cpn60_TCP1 PF00118.24 EDO06864.1 - 8.1e-149 496.4 23.3 9.2e-149 496.2 23.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family zf-CCCH_4 PF18044.1 EDO06865.1 - 0.02 14.7 5.9 0.044 13.6 5.9 1.6 1 0 0 1 1 1 0 CCCH-type zinc finger Torus PF16131.5 EDO06865.1 - 0.042 14.5 1.2 0.076 13.7 1.2 1.3 1 0 0 1 1 1 0 Torus domain zf_CCCH_4 PF18345.1 EDO06865.1 - 0.14 12.2 4.8 0.29 11.2 3.8 2.2 2 0 0 2 2 2 0 Zinc finger domain WD40 PF00400.32 EDO06865.1 - 0.28 12.1 3.7 7.7 7.6 1.2 3.6 2 1 0 2 2 2 0 WD domain, G-beta repeat zf-CCCH_2 PF14608.6 EDO06865.1 - 0.36 11.4 6.4 0.96 10.0 6.4 1.8 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger RRM_1 PF00076.22 EDO06867.1 - 2.3e-15 56.2 0.0 4.3e-15 55.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO06867.1 - 0.0015 18.6 0.0 0.0035 17.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif TPR_14 PF13428.6 EDO06868.1 - 4.8e-10 39.4 0.0 0.12 13.3 0.0 4.3 2 1 2 4 4 4 3 Tetratricopeptide repeat Suf PF05843.14 EDO06868.1 - 5.4e-10 39.7 2.2 7.6e-07 29.4 0.3 3.3 2 1 0 2 2 2 1 Suppressor of forked protein (Suf) Mad3_BUB1_I PF08311.12 EDO06868.1 - 0.0051 16.8 1.5 6.6 6.7 0.2 3.3 3 1 0 3 3 3 2 Mad3/BUB1 homology region 1 TPR_19 PF14559.6 EDO06868.1 - 0.011 16.3 0.0 2.2 8.8 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EDO06868.1 - 0.012 15.6 0.0 0.62 10.3 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat PPR PF01535.20 EDO06868.1 - 0.02 15.1 0.6 0.98 9.8 0.0 3.4 3 0 0 3 3 3 0 PPR repeat TPR_16 PF13432.6 EDO06868.1 - 0.022 15.4 0.0 21 5.9 0.0 3.5 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 EDO06868.1 - 0.035 13.9 0.0 1.8 8.5 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EDO06868.1 - 0.087 13.1 0.0 0.8 10.1 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat ParD_antitoxin PF03693.14 EDO06868.1 - 0.09 13.2 0.6 6.7 7.2 0.1 3.0 3 0 0 3 3 3 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH S1 PF00575.23 EDO06869.1 - 8.9e-08 32.4 9.5 0.00012 22.4 0.0 4.2 4 0 0 4 4 4 3 S1 RNA binding domain Caldesmon PF02029.15 EDO06870.1 - 6.6e-06 25.2 8.2 6.6e-06 25.2 8.2 2.3 2 0 0 2 2 2 1 Caldesmon PCI PF01399.27 EDO06870.1 - 0.0081 16.7 0.0 0.0081 16.7 0.0 4.3 4 1 1 5 5 5 1 PCI domain DUF3685 PF12452.8 EDO06870.1 - 0.077 12.7 0.0 0.077 12.7 0.0 4.6 5 1 1 6 6 6 0 Protein of unknown function (DUF3685) Dynein_light PF01221.18 EDO06871.1 - 5.3e-36 122.8 0.6 6.1e-36 122.6 0.6 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 RNA_pol_Rpb8 PF03870.15 EDO06872.1 - 6.3e-40 136.6 0.2 7.1e-40 136.4 0.2 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 EDO06872.1 - 0.00043 20.3 0.2 0.017 15.2 0.2 2.0 1 1 0 1 1 1 1 DNA-directed RNA polymerase, subunit G RBB1NT PF08169.11 EDO06872.1 - 0.12 12.5 0.1 0.29 11.3 0.1 1.6 2 0 0 2 2 2 0 RBB1NT (NUC162) domain CelTOS PF18659.1 EDO06873.1 - 1.7e-34 118.8 0.7 2.2e-34 118.5 0.7 1.1 1 0 0 1 1 1 1 Cell-traversal protein for ookinetes and sporozoites Phytoreo_Pns PF05451.11 EDO06873.1 - 0.00092 18.4 0.1 0.00098 18.4 0.1 1.2 1 0 0 1 1 1 1 Phytoreovirus nonstructural protein Pns10/11 MOR2-PAG1_C PF14225.6 EDO06873.1 - 0.027 14.3 0.0 0.031 14.1 0.0 1.1 1 0 0 1 1 1 0 Cell morphogenesis C-terminal GerPC PF10737.9 EDO06873.1 - 0.054 13.6 0.2 0.078 13.0 0.2 1.2 1 0 0 1 1 1 0 Spore germination protein GerPC Aconitase_B_N PF11791.8 EDO06873.1 - 0.098 12.7 0.5 0.18 11.9 0.5 1.5 1 1 0 1 1 1 0 Aconitate B N-terminal domain Sof1 PF04158.14 EDO06874.1 - 2.6e-23 82.1 11.1 4.6e-23 81.3 11.1 1.3 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 EDO06874.1 - 2.3e-16 59.8 10.1 0.0018 19.1 0.0 7.1 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO06874.1 - 6.6e-05 23.1 0.0 3.4 8.0 0.0 4.2 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DUF4456 PF14644.6 EDO06874.1 - 0.0068 16.1 1.1 0.013 15.2 1.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4456) HECT PF00632.25 EDO06876.1 - 3.1e-91 306.1 0.0 5.7e-91 305.2 0.0 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF908 PF06012.12 EDO06876.1 - 9.5e-52 176.6 5.3 3.1e-51 174.9 5.3 2.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF908) DUF913 PF06025.12 EDO06876.1 - 2.1e-49 168.5 0.0 2.1e-49 168.5 0.0 2.3 2 0 0 2 2 2 1 Domain of Unknown Function (DUF913) UBM PF14377.6 EDO06876.1 - 4.6e-10 38.6 2.0 2e-05 23.8 0.9 3.7 4 0 0 4 4 4 2 Ubiquitin binding region DUF1765 PF08578.10 EDO06876.1 - 4.1 7.9 13.9 1 9.8 0.1 5.1 5 0 0 5 5 5 0 Protein of unknown function (DUF1765) EF-hand_1 PF00036.32 EDO06877.1 - 3.4e-28 95.1 10.7 1.8e-07 30.2 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EDO06877.1 - 4.7e-25 87.8 4.7 2.6e-12 47.0 2.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EDO06877.1 - 8.2e-23 80.0 11.4 4.1e-08 33.0 0.6 3.9 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 EDO06877.1 - 4.8e-22 76.0 8.2 9.8e-07 28.2 0.0 4.5 4 1 1 5 5 5 4 EF-hand domain EF-hand_9 PF14658.6 EDO06877.1 - 5.2e-14 52.3 0.2 2.9e-06 27.5 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EDO06877.1 - 5.7e-12 44.5 10.7 0.0013 18.1 0.4 3.7 4 0 0 4 4 4 3 EF hand EF-hand_4 PF12763.7 EDO06877.1 - 0.00025 20.9 3.2 0.52 10.3 0.0 3.2 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 EDO06877.1 - 0.0058 16.6 0.9 11 6.0 0.0 3.3 1 1 3 4 4 4 1 Caleosin related protein EF-hand_14 PF17959.1 EDO06877.1 - 0.018 15.4 1.5 3.3 8.1 0.1 2.5 2 1 0 2 2 2 0 EF-hand domain SPARC_Ca_bdg PF10591.9 EDO06877.1 - 0.029 14.7 0.5 2 8.8 0.2 2.1 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region SurA_N_2 PF13623.6 EDO06877.1 - 0.066 13.1 0.1 2.5 8.0 0.0 2.4 2 1 0 2 2 2 0 SurA N-terminal domain TerB PF05099.13 EDO06877.1 - 0.093 12.7 0.0 6.1 6.8 0.0 2.0 1 1 1 2 2 2 0 Tellurite resistance protein TerB SHS2_Rpb7-N PF03876.17 EDO06878.1 - 1.7e-15 57.1 0.0 2.8e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 EDO06878.1 - 4.7e-09 36.5 0.0 9e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 S1 RNA binding domain AhpC-TSA PF00578.21 EDO06879.1 - 2.9e-15 56.3 0.0 3.8e-15 55.9 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EDO06879.1 - 2.3e-10 40.4 0.0 3.1e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 Redoxin Rsm22 PF09243.10 EDO06880.1 - 3.7e-08 33.0 0.0 5.4e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 XPC-binding PF09280.11 EDO06880.1 - 0.026 14.2 0.2 0.063 13.0 0.2 1.6 1 0 0 1 1 1 0 XPC-binding domain Acyltransferase PF01553.21 EDO06881.1 - 3.1e-16 59.2 0.0 1.1e-08 34.8 0.0 2.3 2 0 0 2 2 2 2 Acyltransferase RseC_MucC PF04246.12 EDO06881.1 - 3.1 7.8 5.2 22 5.0 0.0 2.6 2 1 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC TPR_2 PF07719.17 EDO06882.1 - 7.3e-15 53.8 2.4 4.7e-05 23.2 0.3 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 EDO06882.1 - 1.6e-13 49.8 2.7 7.3e-06 25.6 0.3 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 EDO06882.1 - 6.9e-12 45.8 0.4 1.6e-10 41.5 0.1 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDO06882.1 - 2.2e-09 37.3 0.3 0.00012 22.6 0.1 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDO06882.1 - 2.1e-08 33.7 3.9 0.0017 18.4 0.2 2.9 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDO06882.1 - 4.8e-07 30.2 0.6 0.0043 17.5 0.2 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDO06882.1 - 1.1e-06 28.3 1.5 0.0015 18.4 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EDO06882.1 - 1.2e-05 25.3 4.1 0.067 13.3 0.6 2.6 1 1 1 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_11 PF13414.6 EDO06882.1 - 0.00025 20.7 3.7 0.059 13.1 1.5 3.1 2 1 1 3 3 3 1 TPR repeat TPR_12 PF13424.6 EDO06882.1 - 0.00037 20.7 3.4 0.00096 19.4 2.5 2.1 2 1 0 2 2 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDO06882.1 - 0.0014 19.1 1.0 2.1 9.1 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO06882.1 - 0.0045 17.2 1.3 0.024 14.9 2.4 1.7 2 0 0 2 2 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EDO06882.1 - 0.0083 16.4 2.6 9.2 6.9 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat Rapsyn_N PF10579.9 EDO06882.1 - 0.0087 16.1 0.0 26 5.0 0.0 3.3 2 1 1 3 3 3 0 Rapsyn N-terminal myristoylation and linker region Mic1 PF07035.12 EDO06882.1 - 0.015 15.0 0.6 2.1 8.1 0.0 2.4 1 1 1 2 2 2 0 Colon cancer-associated protein Mic1-like TAF1_subA PF14929.6 EDO06882.1 - 0.016 14.7 0.9 0.03 13.7 0.9 1.5 1 1 0 1 1 1 0 TAF RNA Polymerase I subunit A TPR_10 PF13374.6 EDO06882.1 - 0.11 12.4 2.6 1.7 8.6 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_20 PF14561.6 EDO06882.1 - 0.21 12.0 1.0 16 6.0 0.1 3.0 1 1 1 2 2 2 0 Tetratricopeptide repeat EF-hand_7 PF13499.6 EDO06883.1 - 7.1e-25 87.3 4.4 8.9e-10 38.9 0.1 4.9 4 1 0 4 4 4 3 EF-hand domain pair Metallophos PF00149.28 EDO06883.1 - 1.4e-19 71.4 0.2 2.9e-19 70.4 0.2 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase EF-hand_6 PF13405.6 EDO06883.1 - 2.6e-13 48.7 3.0 0.0033 17.2 0.0 6.5 6 0 0 6 6 6 3 EF-hand domain EF-hand_1 PF00036.32 EDO06883.1 - 2.4e-11 42.3 0.9 0.025 14.1 0.0 6.0 6 0 0 6 6 6 2 EF hand EF-hand_8 PF13833.6 EDO06883.1 - 5.6e-08 32.5 1.8 0.00019 21.2 0.0 3.9 4 0 0 4 4 4 2 EF-hand domain pair IQ PF00612.27 EDO06883.1 - 0.00018 21.0 1.4 0.00045 19.8 1.4 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif Caleosin PF05042.13 EDO06883.1 - 0.05 13.5 0.2 6 6.8 0.0 3.5 3 1 0 3 3 3 0 Caleosin related protein MS_channel PF00924.18 EDO06883.1 - 0.081 12.5 0.3 0.21 11.1 0.3 1.6 1 0 0 1 1 1 0 Mechanosensitive ion channel NTF2 PF02136.20 EDO06883.1 - 0.11 13.1 0.1 0.33 11.5 0.1 1.8 1 0 0 1 1 1 0 Nuclear transport factor 2 (NTF2) domain CNH PF00780.22 EDO06884.1 - 1.7e-07 31.1 0.0 4.4e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 CNH domain Vps39_2 PF10367.9 EDO06884.1 - 3.2e-05 24.3 0.0 3.2e-05 24.3 0.0 3.0 3 1 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 EDO06884.1 - 0.0045 16.9 3.3 0.0045 16.9 3.3 2.9 2 0 0 2 2 2 1 Region in Clathrin and VPS Vps39_1 PF10366.9 EDO06884.1 - 2 8.8 11.8 2.9 8.2 2.5 3.2 2 1 1 3 3 3 0 Vacuolar sorting protein 39 domain 1 Pkinase PF00069.25 EDO06885.1 - 1.3e-05 24.7 0.1 0.00031 20.2 0.0 3.0 2 1 0 2 2 2 1 Protein kinase domain Cep57_MT_bd PF06657.13 EDO06885.1 - 1.6 9.3 4.6 9.4 6.8 0.5 3.2 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 PRESAN PF09687.10 EDO06885.1 - 2.7 8.6 10.2 10 6.7 1.3 2.7 2 0 0 2 2 2 0 Plasmodium RESA N-terminal BCIP PF13862.6 EDO06886.1 - 3.2e-38 131.6 0.1 3.2e-38 131.6 0.1 1.9 2 0 0 2 2 2 1 p21-C-terminal region-binding protein RF-1 PF00472.20 EDO06887.1 - 8.3e-18 64.4 1.8 1.1e-17 64.0 1.8 1.1 1 0 0 1 1 1 1 RF-1 domain APG6_N PF17675.1 EDO06887.1 - 0.01 16.4 2.3 0.014 15.9 2.3 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region PELOTA_1 PF15608.6 EDO06887.1 - 0.057 13.3 0.8 0.11 12.3 0.8 1.4 1 0 0 1 1 1 0 PELOTA RNA binding domain FliJ PF02050.16 EDO06887.1 - 0.35 11.1 11.5 0.56 10.4 11.5 1.3 1 0 0 1 1 1 0 Flagellar FliJ protein Helicase_C PF00271.31 EDO06888.1 - 1.1e-16 61.2 0.0 3.2e-16 59.7 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDO06888.1 - 7.3e-15 55.2 0.0 4e-08 33.2 0.0 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase Methyltransf_25 PF13649.6 EDO06888.1 - 5e-05 23.9 0.0 0.24 12.2 0.0 3.5 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_32 PF13679.6 EDO06888.1 - 0.0037 17.3 0.0 0.015 15.3 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain KSHV_K1 PF11049.8 EDO06888.1 - 0.13 12.3 0.2 0.31 11.0 0.2 1.7 1 0 0 1 1 1 0 Glycoprotein K1 of Kaposi's sarcoma-associated herpes virus Fer2_3 PF13085.6 EDO06889.1 - 2e-35 121.1 0.1 3.3e-35 120.4 0.1 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 EDO06889.1 - 1.6e-10 41.4 5.5 1.6e-10 41.4 5.5 2.5 2 1 1 3 3 3 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 EDO06889.1 - 2e-08 34.2 4.1 2e-08 34.2 4.1 2.9 2 1 1 3 3 3 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 EDO06889.1 - 2.5e-08 34.2 9.3 1.5e-05 25.3 9.7 2.9 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer2 PF00111.27 EDO06889.1 - 0.014 15.3 2.7 0.014 15.3 2.7 2.4 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain Fer4_22 PF17179.4 EDO06889.1 - 0.61 11.0 10.7 6.7 7.6 0.4 3.4 3 0 0 3 3 3 0 4Fe-4S dicluster domain Fer4_7 PF12838.7 EDO06889.1 - 5.9 7.6 23.4 0.044 14.4 8.9 3.4 2 2 1 3 3 3 0 4Fe-4S dicluster domain Fer4_9 PF13187.6 EDO06889.1 - 6 7.1 21.5 0.29 11.3 9.2 3.6 1 1 2 3 3 3 0 4Fe-4S dicluster domain Bromodomain PF00439.25 EDO06890.1 - 4.3e-16 58.8 0.1 1.3e-15 57.2 0.1 1.8 1 0 0 1 1 1 1 Bromodomain DUF1674 PF07896.12 EDO06892.1 - 0.0001 22.7 0.0 0.00021 21.7 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) Virulence_fact PF13769.6 EDO06893.1 - 0.1 12.8 0.0 0.29 11.4 0.0 1.7 2 0 0 2 2 2 0 Virulence factor Ndc80_HEC PF03801.13 EDO06894.1 - 2e-17 63.2 0.1 5e-17 61.9 0.1 1.7 1 0 0 1 1 1 1 HEC/Ndc80p family Smac_DIABLO PF09057.10 EDO06894.1 - 0.0036 16.7 0.7 0.0036 16.7 0.7 3.1 2 1 1 3 3 3 1 Second Mitochondria-derived Activator of Caspases SnoaL PF07366.12 EDO06894.1 - 0.02 14.7 0.0 9.2 6.1 0.0 2.9 2 0 0 2 2 2 0 SnoaL-like polyketide cyclase TMV_coat PF00721.21 EDO06894.1 - 0.086 12.7 9.5 0.59 9.9 2.4 2.9 2 1 0 2 2 2 0 Virus coat protein (TMV like) DUF1081 PF06448.11 EDO06894.1 - 2 8.9 5.9 0.84 10.0 1.0 2.7 2 2 0 2 2 2 0 Domain of Unknown Function (DUF1081) BST2 PF16716.5 EDO06894.1 - 2.7 8.6 38.1 7 7.3 11.4 5.0 4 1 0 4 4 4 0 Bone marrow stromal antigen 2 Ribonuc_2-5A PF06479.12 EDO06894.1 - 9.1 6.5 7.9 0.95 9.6 0.5 3.0 2 1 1 3 3 3 0 Ribonuclease 2-5A WD40 PF00400.32 EDO06895.1 - 4.1e-28 97.1 6.1 3.2e-06 27.7 0.2 5.8 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO06895.1 - 1.7e-14 53.8 0.1 1.5e-05 25.2 0.0 5.3 2 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain LisH_TPL PF17814.1 EDO06895.1 - 2.2e-13 49.6 0.2 5e-13 48.4 0.2 1.6 1 0 0 1 1 1 1 LisH-like dimerisation domain Ge1_WD40 PF16529.5 EDO06895.1 - 7.9e-06 25.1 0.3 0.11 11.4 0.0 4.0 2 2 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EDO06895.1 - 1.6e-05 24.4 0.3 0.0067 15.8 0.2 3.0 3 0 0 3 3 3 1 WD40-like domain Nucleoporin_N PF08801.11 EDO06895.1 - 0.019 13.7 2.0 2 7.0 0.0 3.1 1 1 1 3 3 3 0 Nup133 N terminal like PQQ_3 PF13570.6 EDO06895.1 - 0.028 14.9 0.0 7.4 7.2 0.0 3.0 2 0 0 2 2 2 0 PQQ-like domain PQQ PF01011.21 EDO06895.1 - 0.045 13.7 0.0 0.2 11.7 0.0 2.1 1 0 0 1 1 1 0 PQQ enzyme repeat PHTB1_N PF14727.6 EDO06895.1 - 0.069 12.5 0.1 9.7 5.4 0.0 2.9 2 1 0 3 3 3 0 PTHB1 N-terminus Nup160 PF11715.8 EDO06895.1 - 0.085 11.5 0.0 1.7 7.2 0.0 2.4 1 1 1 2 2 2 0 Nucleoporin Nup120/160 ATP-synt PF00231.19 EDO06896.1 - 1.4e-79 267.8 0.3 1.5e-79 267.6 0.3 1.0 1 0 0 1 1 1 1 ATP synthase Ribosomal_S9 PF00380.19 EDO06897.1 - 1e-33 116.4 0.2 1.2e-33 116.2 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Ribosomal_L13e PF01294.18 EDO06898.1 - 3.2e-62 209.6 1.7 3.8e-62 209.3 1.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L13e FAINT PF04385.15 EDO06900.1 - 0.025 14.6 0.0 0.054 13.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function, DUF529 GTP_EFTU PF00009.27 EDO06901.1 - 8.1e-54 182.1 0.0 1.2e-53 181.6 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 EDO06901.1 - 8.8e-11 41.7 0.0 2.4e-10 40.4 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 EDO06901.1 - 5.6e-06 26.4 0.1 3.5e-05 23.9 0.1 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 EDO06901.1 - 0.0019 17.6 0.4 0.0036 16.6 0.0 1.6 2 0 0 2 2 2 1 AIG1 family RF3_C PF16658.5 EDO06901.1 - 0.041 13.7 0.0 0.073 12.9 0.0 1.3 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain Septin PF00735.18 EDO06901.1 - 0.042 13.1 0.0 0.085 12.1 0.0 1.4 1 0 0 1 1 1 0 Septin Hydantoinase_A PF01968.18 EDO06901.1 - 0.043 13.1 0.0 0.087 12.1 0.0 1.4 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase MobB PF03205.14 EDO06901.1 - 0.082 12.8 0.1 0.54 10.1 0.0 2.3 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B SBDS PF01172.18 EDO06902.1 - 5.7e-31 106.5 0.3 1.2e-30 105.4 0.3 1.6 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 EDO06902.1 - 1.2e-26 93.0 0.2 3.1e-26 91.7 0.2 1.6 1 0 0 1 1 1 1 SBDS protein C-terminal domain Phage_TAC_5 PF08890.11 EDO06902.1 - 0.0064 16.5 0.1 0.017 15.1 0.1 1.7 1 0 0 1 1 1 1 Phage XkdN-like tail assembly chaperone protein, TAC zf-C2H2_jaz PF12171.8 EDO06902.1 - 0.022 15.1 0.9 0.064 13.6 0.9 1.9 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding CDT1_C PF16679.5 EDO06902.1 - 0.74 10.3 4.1 0.45 11.0 0.8 2.3 3 0 0 3 3 3 0 DNA replication factor Cdt1 C-terminal domain ING PF12998.7 EDO06903.1 - 1.9e-07 31.6 0.2 0.00031 21.3 0.0 2.6 3 0 0 3 3 3 2 Inhibitor of growth proteins N-terminal histone-binding Macoilin PF09726.9 EDO06903.1 - 0.46 9.0 9.9 0.59 8.6 9.9 1.1 1 0 0 1 1 1 0 Macoilin family Tmemb_cc2 PF10267.9 EDO06903.1 - 1.1 8.3 9.1 1.2 8.3 8.2 1.3 1 1 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein RAP PF08373.10 EDO06904.1 - 9.2e-08 32.1 0.0 1.9e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 RAP domain DUF764 PF05561.11 EDO06904.1 - 0.11 12.3 0.3 0.25 11.1 0.3 1.5 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF764) DUF3797 PF12677.7 EDO06905.1 - 0.027 14.3 0.1 0.053 13.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3797) Ribosomal_S13 PF00416.22 EDO06906.1 - 2.8e-48 163.5 2.7 3.2e-48 163.3 2.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 DUF2746 PF10874.8 EDO06906.1 - 0.016 15.6 0.0 0.027 14.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2746) FbpA PF05833.11 EDO06906.1 - 0.016 14.0 0.0 0.018 13.9 0.0 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) Trp_oprn_chp PF09534.10 EDO06906.1 - 0.073 12.9 0.2 0.1 12.4 0.2 1.2 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) IMS_HHH PF11798.8 EDO06906.1 - 0.14 12.6 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 IMS family HHH motif Ribosomal_L5_C PF00673.21 EDO06907.1 - 5.3e-22 77.8 0.0 7.4e-22 77.3 0.0 1.2 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EDO06907.1 - 1.1e-16 60.9 0.0 1.9e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 ACT_5 PF13710.6 EDO06907.1 - 0.022 14.6 0.0 0.049 13.5 0.0 1.6 1 0 0 1 1 1 0 ACT domain DUF4078 PF13300.6 EDO06908.1 - 0.074 13.4 10.9 0.23 11.8 10.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4078) DUF4776 PF16003.5 EDO06908.1 - 0.83 8.6 7.3 1.2 8.1 7.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) Actin PF00022.19 EDO06909.1 - 2.6e-60 204.2 0.0 5.2e-30 104.4 0.0 2.1 1 1 1 2 2 2 2 Actin CDC50 PF03381.15 EDO06910.1 - 2.3e-37 129.1 0.2 3.1e-37 128.6 0.2 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family COPI_assoc PF08507.10 EDO06910.1 - 0.21 11.6 3.0 0.16 12.0 0.9 1.8 2 0 0 2 2 2 0 COPI associated protein CaM_binding PF07839.11 EDO06911.1 - 0.062 14.0 0.0 0.073 13.8 0.0 1.2 1 0 0 1 1 1 0 Plant calmodulin-binding domain WD40 PF00400.32 EDO06912.1 - 3.6e-05 24.5 14.6 0.0011 19.7 0.5 6.3 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO06912.1 - 0.0015 18.8 0.1 9.2 6.6 0.0 3.7 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Pkinase PF00069.25 EDO06913.1 - 9.2e-59 199.0 0.1 1.5e-38 132.7 0.0 2.9 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO06913.1 - 2.2e-28 99.3 0.0 3.2e-23 82.3 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EDO06913.1 - 0.012 14.5 0.1 0.02 13.9 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain YokU PF14122.6 EDO06913.1 - 0.059 13.4 0.0 1.2 9.2 0.0 2.4 2 0 0 2 2 2 0 YokU-like protein, putative antitoxin ANAPC4_WD40 PF12894.7 EDO06914.1 - 3.8e-16 59.1 0.5 0.013 15.8 0.0 5.6 4 1 0 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO06914.1 - 4.1e-15 55.9 18.4 0.00051 20.8 0.4 7.7 7 0 0 7 7 7 4 WD domain, G-beta repeat eIF2A PF08662.11 EDO06914.1 - 0.006 16.5 0.1 0.25 11.2 0.0 2.7 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A PQQ PF01011.21 EDO06914.1 - 0.022 14.7 0.4 0.072 13.0 0.4 2.0 1 0 0 1 1 1 0 PQQ enzyme repeat WD40_like PF17005.5 EDO06914.1 - 0.13 11.6 0.6 3.5 6.9 0.1 2.2 2 0 0 2 2 2 0 WD40-like domain RabGAP-TBC PF00566.18 EDO06915.1 - 5.8e-50 169.9 0.5 5.8e-50 169.9 0.5 1.6 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Integrin_b_cyt PF08725.11 EDO06915.1 - 0.2 11.4 3.7 0.44 10.3 3.7 1.5 1 0 0 1 1 1 0 Integrin beta cytoplasmic domain RAP PF08373.10 EDO06916.1 - 1.9e-05 24.6 1.4 8e-05 22.7 0.0 2.3 2 0 0 2 2 2 1 RAP domain IMPDH PF00478.25 EDO06917.1 - 1.3e-60 205.2 0.8 3.5e-60 203.8 0.8 1.6 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EDO06917.1 - 1.1e-06 27.9 3.8 1.2e-05 24.5 2.1 2.2 1 1 0 2 2 2 2 FMN-dependent dehydrogenase Glu_synthase PF01645.17 EDO06917.1 - 0.01 15.0 0.8 0.017 14.3 0.1 1.7 2 0 0 2 2 2 0 Conserved region in glutamate synthase Peptidase_M24 PF00557.24 EDO06918.1 - 1.6e-21 76.9 0.4 2.2e-21 76.5 0.4 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 BHD_1 PF10403.9 EDO06920.1 - 1.9e-10 40.4 0.0 5.5e-10 38.9 0.0 1.8 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_3 PF10405.9 EDO06920.1 - 6.6e-09 36.1 0.0 1.3e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 Methyltrn_RNA_3 PF02598.17 EDO06921.1 - 5.5e-67 226.3 0.0 7.9e-64 215.9 0.0 2.2 1 1 0 1 1 1 1 Putative RNA methyltransferase DUF1280 PF06918.14 EDO06921.1 - 0.12 11.9 0.0 2.1 7.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1280) Ubiquitin_2 PF14560.6 EDO06922.1 - 7.5e-22 77.6 2.1 1.8e-21 76.4 0.0 2.3 3 0 0 3 3 3 1 Ubiquitin-like domain CAP_GLY PF01302.25 EDO06922.1 - 1e-13 51.1 0.3 1.7e-13 50.3 0.3 1.4 1 0 0 1 1 1 1 CAP-Gly domain ubiquitin PF00240.23 EDO06922.1 - 0.00025 20.7 1.9 0.006 16.3 0.0 3.3 3 1 0 3 3 3 1 Ubiquitin family Tcp10_C PF07202.13 EDO06922.1 - 0.025 14.5 0.1 0.041 13.8 0.1 1.4 1 0 0 1 1 1 0 T-complex protein 10 C-terminus Tae4 PF14113.6 EDO06922.1 - 0.1 12.8 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 Type VI secretion system (T6SS), amidase effector protein 4 Ubiquitin_4 PF18036.1 EDO06922.1 - 0.15 12.1 0.2 2.5 8.2 0.0 2.8 2 1 0 2 2 2 0 Ubiquitin-like domain Ribosomal_L13 PF00572.18 EDO06923.1 - 1.7e-14 54.2 0.0 2.3e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L13 Helicase_Sgs1 PF11408.8 EDO06924.1 - 0.13 12.3 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 Sgs1 RecQ helicase TMEM156 PF15106.6 EDO06924.1 - 4.5 6.6 5.1 11 5.4 0.3 3.0 3 0 0 3 3 3 0 TMEM156 protein family Peptidase_S49_N PF08496.10 EDO06924.1 - 7 6.7 5.1 28 4.7 0.1 3.0 3 0 0 3 3 3 0 Peptidase family S49 N-terminal DUF3357 PF11837.8 EDO06924.1 - 7.7 7.0 11.2 42 4.6 0.5 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF3357) VESA1_N PF12785.7 EDO06925.1 - 5.2e-08 32.3 15.6 9.4e-08 31.4 15.6 1.4 1 1 0 1 1 1 1 Variant erythrocyte surface antigen-1 CBF_beta PF02312.17 EDO06925.1 - 0.069 12.8 0.0 0.099 12.3 0.0 1.2 1 0 0 1 1 1 0 Core binding factor beta subunit TIG PF01833.24 EDO06925.1 - 0.38 10.9 3.2 0.7 10.0 3.2 1.4 1 0 0 1 1 1 0 IPT/TIG domain LMP PF04778.12 EDO06927.1 - 0.025 14.5 2.7 0.057 13.3 2.2 1.8 1 1 0 1 1 1 0 LMP repeated region SesA PF17107.5 EDO06927.1 - 0.078 13.2 2.2 1.8 8.8 0.2 2.3 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF2616 PF11077.8 EDO06927.1 - 0.15 11.8 4.0 0.063 13.0 0.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2616) VESA1_N PF12785.7 EDO06928.1 - 7.4e-23 81.2 13.7 7.4e-23 81.2 13.7 4.3 3 1 1 4 4 4 2 Variant erythrocyte surface antigen-1 SUIM_assoc PF16619.5 EDO06928.1 - 1.1 9.4 8.0 2.7 8.1 8.0 1.7 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 VESA1_N PF12785.7 EDO06929.1 - 1.5e-220 732.9 21.7 1.5e-220 732.9 21.7 2.7 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 Thioredoxin_4 PF13462.6 EDO06929.1 - 0.013 15.7 0.5 0.26 11.4 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin ALIX_LYPXL_bnd PF13949.6 EDO06929.1 - 0.028 13.7 0.5 0.051 12.9 0.5 1.3 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV ERM PF00769.19 EDO06929.1 - 0.11 12.3 0.6 0.24 11.2 0.6 1.5 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF4175 PF13779.6 EDO06929.1 - 0.68 7.8 6.7 0.76 7.6 6.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4175) Hydrolase_4 PF12146.8 EDO06930.1 - 7.6e-06 25.4 0.2 0.001 18.4 0.0 2.5 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDO06930.1 - 0.0063 16.2 0.0 0.0098 15.6 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold FSH1 PF03959.13 EDO06930.1 - 0.029 14.0 0.0 0.039 13.6 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_4 PF08386.10 EDO06930.1 - 0.046 13.8 0.0 0.072 13.2 0.0 1.3 1 0 0 1 1 1 0 TAP-like protein Peptidase_S9 PF00326.21 EDO06930.1 - 0.067 12.7 0.1 0.14 11.6 0.0 1.6 2 0 0 2 2 2 0 Prolyl oligopeptidase family Ribosomal_L13 PF00572.18 EDO06931.1 - 8.1e-37 126.3 0.2 1.1e-36 125.9 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 Sec23_trunk PF04811.15 EDO06934.1 - 2.7e-16 59.9 0.0 4.4e-16 59.2 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EDO06934.1 - 1.6e-14 54.4 0.1 3.7e-14 53.2 0.1 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 EDO06934.1 - 4.4e-08 32.9 0.2 1.3e-07 31.3 0.2 1.8 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 EDO06934.1 - 6.7e-08 32.5 0.8 2.2e-07 30.8 0.8 2.0 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EDO06934.1 - 0.00015 21.6 0.0 0.00031 20.6 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Coleoptericin PF06286.11 EDO06934.1 - 0.022 14.9 0.3 0.048 13.8 0.3 1.5 1 0 0 1 1 1 0 Coleoptericin Helicase_C PF00271.31 EDO06935.1 - 8e-27 93.8 0.1 2.4e-26 92.2 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDO06935.1 - 4.2e-21 75.5 0.0 1.7e-18 67.0 0.0 3.2 2 1 0 2 2 2 1 DEAD/DEAH box helicase LSM PF01423.22 EDO06937.1 - 6.7e-19 67.3 0.0 8.1e-19 67.1 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EDO06937.1 - 3.7e-07 30.2 0.0 4.7e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain Hfq PF17209.3 EDO06937.1 - 0.08 12.6 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Hfq protein dUTPase PF00692.19 EDO06938.1 - 9.7e-19 67.3 0.0 5.3e-17 61.7 0.0 2.1 1 1 0 1 1 1 1 dUTPase Rhomboid PF01694.22 EDO06940.1 - 1e-13 51.6 8.1 2.1e-13 50.6 8.1 1.5 1 0 0 1 1 1 1 Rhomboid family Pkinase_C PF00433.24 EDO06940.1 - 0.096 13.4 0.5 0.19 12.4 0.5 1.5 1 0 0 1 1 1 0 Protein kinase C terminal domain DnaJ PF00226.31 EDO06941.1 - 0.0041 17.2 0.1 0.01 15.9 0.1 1.6 1 0 0 1 1 1 1 DnaJ domain DNA_pol_A PF00476.20 EDO06942.1 - 1.8e-81 274.1 0.1 2.8e-81 273.5 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase family A AAA_25 PF13481.6 EDO06942.1 - 4.9e-30 104.6 0.0 9.3e-30 103.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain DNA_pol_A_exo1 PF01612.20 EDO06942.1 - 3e-27 95.5 0.0 5.4e-27 94.6 0.0 1.4 1 0 0 1 1 1 1 3'-5' exonuclease DnaB_C PF03796.15 EDO06942.1 - 2.3e-06 27.1 0.0 6.8e-06 25.6 0.0 1.8 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_22 PF13401.6 EDO06942.1 - 0.00015 22.1 0.1 0.00055 20.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 EDO06942.1 - 0.0002 20.8 0.0 0.00038 19.9 0.0 1.4 1 0 0 1 1 1 1 KaiC Toprim_2 PF13155.6 EDO06942.1 - 0.00077 19.8 0.0 0.0021 18.5 0.0 1.8 1 0 0 1 1 1 1 Toprim-like Toprim_4 PF13662.6 EDO06942.1 - 0.011 16.2 0.0 0.029 14.8 0.0 1.7 1 0 0 1 1 1 0 Toprim domain AAA_16 PF13191.6 EDO06942.1 - 0.028 14.8 0.0 0.065 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 EDO06942.1 - 0.57 10.7 2.3 1.8 9.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain MA3 PF02847.17 EDO06943.1 - 2.3e-11 43.6 9.4 3.9e-10 39.7 0.0 3.3 4 0 0 4 4 4 2 MA3 domain MIF4G PF02854.19 EDO06943.1 - 0.00017 21.3 5.1 0.00017 21.3 5.1 2.9 3 1 0 3 3 3 1 MIF4G domain ATP-synt_ab PF00006.25 EDO06944.1 - 1.1e-63 214.7 0.0 1.9e-63 214.0 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EDO06944.1 - 4.1e-18 65.7 0.0 9.8e-18 64.5 0.0 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain NB-ARC PF00931.22 EDO06944.1 - 0.011 14.9 0.1 0.022 13.9 0.1 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA PF00004.29 EDO06944.1 - 0.012 16.1 0.2 0.4 11.1 0.0 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EDO06944.1 - 0.013 15.4 0.1 0.024 14.5 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_16 PF13191.6 EDO06944.1 - 0.014 15.8 0.0 0.03 14.7 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain ATPase PF06745.13 EDO06944.1 - 0.06 12.7 0.6 0.11 11.8 0.6 1.4 1 0 0 1 1 1 0 KaiC NACHT PF05729.12 EDO06944.1 - 0.088 12.7 0.2 0.38 10.7 0.1 1.9 2 0 0 2 2 2 0 NACHT domain AAA_19 PF13245.6 EDO06944.1 - 0.14 12.5 0.9 0.31 11.4 0.3 1.8 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EDO06944.1 - 0.15 12.0 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea SHMT PF00464.19 EDO06945.1 - 3.2e-174 579.2 0.0 3.7e-174 579.0 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase DegT_DnrJ_EryC1 PF01041.17 EDO06945.1 - 0.01 15.2 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family MT-A70 PF05063.14 EDO06946.1 - 3.9e-34 118.0 0.1 4.8e-23 81.9 0.1 2.5 1 1 1 2 2 2 2 MT-A70 Med26 PF08711.11 EDO06947.1 - 1.5e-10 40.9 0.1 2.9e-10 40.0 0.1 1.5 1 0 0 1 1 1 1 TFIIS helical bundle-like domain DUF3884 PF13024.6 EDO06947.1 - 0.16 11.5 0.1 16 5.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3884) Ribosomal_L35p PF01632.19 EDO06949.1 - 3e-12 46.8 12.0 3e-12 46.8 12.0 2.0 1 1 1 2 2 2 1 Ribosomal protein L35 Coatomer_WDAD PF04053.14 EDO06950.1 - 1.4e-101 340.8 0.0 4.5e-101 339.1 0.0 1.7 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 EDO06950.1 - 5.9e-22 77.6 22.4 5.8e-05 23.8 0.0 9.3 9 1 1 10 10 10 5 WD domain, G-beta repeat WD40_like PF17005.5 EDO06950.1 - 0.021 14.2 0.0 1 8.6 0.0 2.7 2 1 0 2 2 2 0 WD40-like domain ANAPC4_WD40 PF12894.7 EDO06950.1 - 0.036 14.3 1.7 14 6.0 0.0 4.6 6 1 1 7 7 7 0 Anaphase-promoting complex subunit 4 WD40 domain Snf7 PF03357.21 EDO06951.1 - 6.6e-07 29.1 9.4 8.9e-07 28.7 9.4 1.1 1 0 0 1 1 1 1 Snf7 VPS11_C PF12451.8 EDO06951.1 - 0.017 15.4 0.1 0.043 14.0 0.1 1.8 1 0 0 1 1 1 0 Vacuolar protein sorting protein 11 C terminal Ist1 PF03398.14 EDO06951.1 - 0.071 13.0 6.1 0.28 11.1 6.1 1.9 1 1 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway Mt_ATP-synt_D PF05873.12 EDO06951.1 - 0.23 11.3 2.7 0.14 12.0 0.4 1.7 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) RNB PF00773.19 EDO06952.1 - 2.9e-90 302.9 0.7 4.1e-90 302.4 0.7 1.2 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 EDO06952.1 - 1.5e-05 24.9 0.0 3.7e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Exo_endo_phos PF03372.23 EDO06953.1 - 1.1e-07 31.6 0.0 7.9e-07 28.8 0.0 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF3458_C PF17432.2 EDO06954.1 - 3.1e-72 243.6 0.8 2.3e-61 207.9 1.2 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF3458_C) ARM repeats Peptidase_M1 PF01433.20 EDO06954.1 - 2.3e-49 167.9 0.2 4.6e-49 166.9 0.2 1.5 1 0 0 1 1 1 1 Peptidase family M1 domain DUF3458 PF11940.8 EDO06954.1 - 2.5e-23 82.3 0.0 6.3e-23 81.0 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3458) Ig-like fold Peptidase_M1_N PF17900.1 EDO06954.1 - 9.3e-13 48.8 0.0 1.9e-12 47.8 0.0 1.5 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain LcrR PF09621.10 EDO06954.1 - 0.0035 16.8 0.1 3.3 7.2 0.0 2.5 2 0 0 2 2 2 2 Type III secretion system regulator (LcrR) Peptidase_M61 PF05299.12 EDO06954.1 - 0.061 13.7 0.0 0.15 12.5 0.0 1.7 1 0 0 1 1 1 0 M61 glycyl aminopeptidase COQ9 PF08511.11 EDO06954.1 - 0.087 12.6 0.0 0.23 11.3 0.0 1.7 1 0 0 1 1 1 0 COQ9 RNase_PH PF01138.21 EDO06955.1 - 4.8e-20 72.4 0.6 1e-19 71.4 0.1 1.7 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EDO06955.1 - 0.0031 17.5 0.1 0.0056 16.7 0.1 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 LRR_9 PF14580.6 EDO06957.1 - 1.5e-13 50.6 1.1 9.5e-12 44.8 0.2 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 EDO06957.1 - 3.1e-09 36.9 10.7 0.00068 20.0 0.3 4.4 3 2 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDO06957.1 - 4.3e-08 32.8 7.2 0.00033 20.4 1.4 3.1 2 1 0 2 2 2 2 Leucine rich repeat Wbp11 PF09429.10 EDO06958.1 - 2.5e-17 63.0 11.7 2.5e-17 63.0 11.7 1.7 2 0 0 2 2 2 1 WW domain binding protein 11 CHAT PF12770.7 EDO06958.1 - 0.094 12.1 0.2 0.13 11.7 0.2 1.1 1 0 0 1 1 1 0 CHAT domain DUF501 PF04417.12 EDO06958.1 - 0.17 11.7 2.0 0.18 11.6 1.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF501) DUF2956 PF11169.8 EDO06958.1 - 3.2 8.0 10.4 1.5 9.0 3.6 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2956) Complex1_30kDa PF00329.19 EDO06959.1 - 0.12 13.0 0.0 0.49 11.0 0.0 2.0 2 0 0 2 2 2 0 Respiratory-chain NADH dehydrogenase, 30 Kd subunit BSD PF03909.17 EDO06960.1 - 0.15 12.1 0.9 0.24 11.4 0.1 1.7 2 1 0 2 2 2 0 BSD domain MFS_1 PF07690.16 EDO06961.1 - 5e-13 48.7 48.1 3.7e-11 42.6 36.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Rota_NS26 PF01525.16 EDO06961.1 - 0.91 9.5 4.5 1.4 8.9 4.5 1.2 1 0 0 1 1 1 0 Rotavirus NS26 PMC2NT PF08066.12 EDO06962.1 - 0.28 11.9 4.5 3.6 8.3 0.0 3.0 3 0 0 3 3 3 0 PMC2NT (NUC016) domain Asn_synthase PF00733.21 EDO06963.1 - 4.6e-13 49.6 0.2 0.00038 20.2 0.0 3.5 2 1 1 3 3 3 3 Asparagine synthase GATase_7 PF13537.6 EDO06963.1 - 0.014 15.3 0.0 0.034 14.0 0.0 1.6 1 0 0 1 1 1 0 Glutamine amidotransferase domain Hydantoinase_A PF01968.18 EDO06963.1 - 0.023 13.9 0.0 2.8 7.1 0.0 2.2 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase ThiI PF02568.14 EDO06963.1 - 0.024 14.2 0.0 0.044 13.4 0.0 1.4 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) HEAT PF02985.22 EDO06964.1 - 0.0001 22.2 4.6 0.18 12.1 0.0 4.1 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 EDO06964.1 - 0.00031 21.1 0.2 0.3 11.5 0.0 3.5 3 0 0 3 3 3 2 HEAT repeats CLASP_N PF12348.8 EDO06964.1 - 0.061 12.9 0.3 7 6.1 0.1 2.5 2 0 0 2 2 2 0 CLASP N terminal Vac14_Fab1_bd PF12755.7 EDO06964.1 - 0.11 13.1 0.5 14 6.3 0.0 3.6 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EDO06964.1 - 0.11 12.6 1.5 2.5 8.1 0.1 3.2 4 0 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 SNF2_assoc PF08455.10 EDO06967.1 - 0.13 11.3 0.0 0.18 10.8 0.0 1.1 1 0 0 1 1 1 0 Bacterial SNF2 helicase associated Ribosomal_L6 PF00347.23 EDO06968.1 - 4.3e-24 85.0 6.2 2.2e-13 50.6 0.9 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 DUF348 PF03990.14 EDO06968.1 - 0.095 12.5 2.9 4.5 7.1 1.1 2.5 2 0 0 2 2 2 0 G5-linked-Ubiquitin-like domain Ribosomal_S15 PF00312.22 EDO06969.1 - 3.6e-20 71.9 0.4 6.1e-20 71.2 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein S15 TPR_8 PF13181.6 EDO06970.1 - 1.2e-16 59.4 0.0 6.5e-05 22.8 0.0 4.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EDO06970.1 - 1e-14 53.3 0.1 0.00059 19.8 0.0 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 EDO06970.1 - 2.4e-14 52.4 1.8 0.00058 19.6 0.0 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 EDO06970.1 - 9.6e-09 35.4 0.0 0.011 16.5 0.0 4.8 3 2 2 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDO06970.1 - 1.6e-08 34.9 0.0 0.0053 17.2 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO06970.1 - 1.3e-06 28.6 0.0 5.8e-05 23.2 0.0 3.0 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EDO06970.1 - 6.6e-06 26.7 0.0 5.7e-05 23.7 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EDO06970.1 - 6e-05 22.6 0.0 0.002 17.7 0.0 3.1 1 1 1 2 2 2 1 TPR repeat TPR_9 PF13371.6 EDO06970.1 - 7.7e-05 22.8 0.0 0.19 11.9 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDO06970.1 - 0.00034 20.9 0.3 0.0084 16.4 0.0 3.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDO06970.1 - 0.00039 20.2 0.0 3.2 8.0 0.0 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDO06970.1 - 0.002 18.7 0.1 0.68 10.7 0.0 3.2 3 0 0 3 3 2 1 Tetratricopeptide repeat RPN7 PF10602.9 EDO06970.1 - 0.038 13.7 0.8 0.97 9.1 0.0 2.9 1 1 2 3 3 3 0 26S proteasome subunit RPN7 TPR_15 PF13429.6 EDO06970.1 - 0.043 13.0 0.0 2.4 7.3 0.0 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF5562 PF17717.1 EDO06970.1 - 0.065 13.2 0.0 0.18 11.8 0.0 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5562) BTAD PF03704.17 EDO06970.1 - 0.1 13.1 0.0 1.1 9.7 0.0 2.4 2 0 0 2 2 2 0 Bacterial transcriptional activator domain TPR_10 PF13374.6 EDO06970.1 - 0.1 12.5 0.2 0.41 10.6 0.2 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat RRM_1 PF00076.22 EDO06971.1 - 0.00086 19.1 0.0 0.0011 18.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO06971.1 - 0.022 14.9 0.0 0.088 12.9 0.0 1.8 1 1 0 1 1 1 0 RNA recognition motif zf-TFIIB PF13453.6 EDO06971.1 - 0.03 13.7 0.1 0.05 12.9 0.1 1.3 1 0 0 1 1 1 0 Transcription factor zinc-finger RNA_bind PF08675.11 EDO06971.1 - 0.1 12.6 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 RNA binding domain DUF1180 PF06679.12 EDO06973.1 - 0.82 10.1 4.5 1.3 9.4 4.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DLEU7 PF15760.5 EDO06973.1 - 1 8.8 3.3 1.7 8.1 3.3 1.3 1 0 0 1 1 1 0 Leukemia-associated protein 7 Mito_fiss_reg PF05308.11 EDO06973.1 - 1.2 9.2 4.5 1.8 8.6 4.5 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator Pkinase PF00069.25 EDO06975.1 - 1.5e-12 47.4 0.3 3.3e-11 43.1 0.1 2.7 1 1 0 2 2 2 1 Protein kinase domain RWD PF05773.22 EDO06975.1 - 1.7e-07 31.6 0.0 5.6e-07 29.9 0.0 2.0 1 0 0 1 1 1 1 RWD domain Pkinase_Tyr PF07714.17 EDO06975.1 - 8.8e-07 28.5 0.2 5e-06 26.0 0.3 2.2 2 1 0 2 2 2 1 Protein tyrosine kinase DUF2778 PF10908.8 EDO06975.1 - 0.094 13.0 0.3 0.58 10.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2778) DUF3800 PF12686.7 EDO06975.1 - 0.14 12.8 0.0 0.73 10.5 0.0 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) RF-1 PF00472.20 EDO06976.1 - 6.2e-28 97.1 3.8 1.4e-27 96.0 3.8 1.6 1 0 0 1 1 1 1 RF-1 domain PCRF PF03462.18 EDO06976.1 - 6.7e-18 65.3 3.2 8.8e-18 64.9 0.2 2.4 2 1 0 2 2 2 1 PCRF domain EssA PF10661.9 EDO06976.1 - 0.066 13.1 4.0 0.12 12.2 4.0 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA TBP PF00352.21 EDO06977.1 - 3.2e-27 94.3 0.9 1.6e-05 24.8 0.0 4.2 4 0 0 4 4 4 4 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EDO06977.1 - 0.0088 16.1 0.5 0.035 14.2 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3378) UFC1 PF08694.11 EDO06978.1 - 1.4e-75 252.2 0.1 1.6e-75 252.0 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 UQ_con PF00179.26 EDO06978.1 - 0.00044 19.9 0.1 0.00076 19.1 0.1 1.5 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EDO06978.1 - 0.0047 17.2 0.0 0.0053 17.0 0.0 1.2 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 EDO06978.1 - 0.028 14.1 0.0 0.037 13.7 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B MIF4G_like_2 PF09090.11 EDO06981.1 - 1e-08 35.0 1.2 2e-08 34.1 0.2 2.0 2 0 0 2 2 2 1 MIF4G like DNA_pol_B PF00136.21 EDO06981.1 - 0.036 12.8 1.2 0.062 12.0 1.2 1.3 1 0 0 1 1 1 0 DNA polymerase family B LRR_9 PF14580.6 EDO06983.1 - 2e-53 180.5 0.1 2.4e-53 180.2 0.1 1.1 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EDO06983.1 - 2.8e-11 43.5 10.6 4.7e-07 30.0 0.5 3.5 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDO06983.1 - 3.8e-09 36.2 8.2 4.6e-08 32.7 3.0 3.5 1 1 2 3 3 3 2 Leucine rich repeat LRR_6 PF13516.6 EDO06983.1 - 0.031 14.3 5.3 1.3 9.2 0.5 4.0 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.33 EDO06983.1 - 0.15 12.7 5.2 47 5.1 0.1 4.7 4 0 0 4 4 4 0 Leucine Rich Repeat Ephrin_rec_like PF07699.13 EDO06984.1 - 1.9e-23 81.9 117.3 8.7e-11 41.4 4.9 12.4 12 1 1 13 13 13 10 Putative ephrin-receptor like Ephrin_rec_like PF07699.13 EDO06985.1 - 4.5e-38 128.8 107.8 3.8e-10 39.4 4.3 11.9 12 2 0 12 12 12 9 Putative ephrin-receptor like He_PIG PF05345.12 EDO06985.1 - 0.0011 19.1 0.3 0.0032 17.6 0.3 1.8 1 0 0 1 1 1 1 Putative Ig domain Tektin PF03148.14 EDO06985.1 - 0.012 14.4 0.5 0.019 13.7 0.5 1.2 1 0 0 1 1 1 0 Tektin family BRE1 PF08647.11 EDO06985.1 - 0.11 12.6 0.2 0.21 11.7 0.2 1.4 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase DUF1192 PF06698.11 EDO06985.1 - 3.1 7.9 4.5 19 5.4 0.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1192) Tau95 PF09734.9 EDO06986.1 - 1.8e-28 100.1 0.1 4.7e-27 95.5 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain HEAT PF02985.22 EDO06987.1 - 0.03 14.6 0.6 9.1 6.8 0.0 5.1 4 0 0 4 4 4 0 HEAT repeat Sec7_N PF12783.7 EDO06987.1 - 0.064 13.2 0.0 0.064 13.2 0.0 5.8 6 1 1 7 7 7 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Ribosomal_L29 PF00831.23 EDO06988.1 - 6.9e-09 35.6 0.7 1.1e-08 34.9 0.7 1.3 1 0 0 1 1 1 1 Ribosomal L29 protein DUF445 PF04286.12 EDO06990.1 - 0.002 18.0 1.0 0.002 18.0 1.0 1.9 2 1 0 2 2 2 1 Protein of unknown function (DUF445) DEK_C PF08766.11 EDO06990.1 - 0.15 12.0 2.1 1.2 9.1 0.2 2.6 2 0 0 2 2 2 0 DEK C terminal domain IPPT PF01715.17 EDO06991.1 - 1.7e-16 60.7 0.0 2.3e-16 60.3 0.0 1.1 1 0 0 1 1 1 1 IPP transferase IPT PF01745.16 EDO06991.1 - 0.0065 15.9 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 Isopentenyl transferase KTI12 PF08433.10 EDO06991.1 - 0.029 13.8 0.0 0.051 13.0 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 SRP54 PF00448.22 EDO06991.1 - 0.047 13.3 0.0 0.11 12.1 0.0 1.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 EDO06991.1 - 0.056 12.7 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_7 PF12775.7 EDO06991.1 - 0.089 12.3 0.0 1.4 8.4 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region IPPT PF01715.17 EDO06992.1 - 9e-12 45.3 0.1 1e-11 45.1 0.1 1.1 1 0 0 1 1 1 1 IPP transferase RRM_1 PF00076.22 EDO06993.1 - 1e-07 31.7 0.0 5.4e-05 22.9 0.0 2.6 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Exo70 PF03081.15 EDO06994.1 - 0.015 14.4 0.1 0.032 13.3 0.1 1.4 1 0 0 1 1 1 0 Exo70 exocyst complex subunit DUF4047 PF13256.6 EDO06996.1 - 0.021 15.0 0.0 0.026 14.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4047) VESA1_N PF12785.7 EDO06997.1 - 1.4e-188 627.5 25.7 1.4e-188 627.5 25.7 2.5 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 F-box-like_2 PF13013.6 EDO06998.1 - 3.5e-13 49.4 14.7 5.6e-05 23.1 0.6 5.5 2 1 3 6 6 6 5 F-box-like domain VESA1_N PF12785.7 EDO06999.1 - 1e-217 723.5 19.9 1e-217 723.5 19.9 2.3 3 0 0 3 3 2 1 Variant erythrocyte surface antigen-1 Apolipoprotein PF01442.18 EDO06999.1 - 0.00088 19.2 4.7 0.0024 17.8 4.7 1.6 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.12 EDO06999.1 - 0.0012 18.9 1.0 0.012 15.6 0.6 2.7 1 1 1 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus ApoLp-III PF07464.11 EDO06999.1 - 0.0037 17.4 6.1 0.019 15.0 6.1 2.2 1 1 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) RRF PF01765.19 EDO06999.1 - 0.0047 16.9 1.6 0.0047 16.9 1.6 2.2 1 1 1 2 2 2 1 Ribosome recycling factor DUF1664 PF07889.12 EDO06999.1 - 0.024 14.7 1.9 3.2 7.8 1.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) PEP-utilisers_N PF05524.13 EDO06999.1 - 0.027 14.6 2.1 6.9 6.9 0.5 2.5 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal Prominin PF05478.11 EDO06999.1 - 0.067 11.1 0.0 0.067 11.1 0.0 2.8 2 1 0 2 2 1 0 Prominin AAA_13 PF13166.6 EDO06999.1 - 0.23 10.1 1.9 0.41 9.2 1.9 1.4 1 0 0 1 1 1 0 AAA domain Rx_N PF18052.1 EDO06999.1 - 0.24 11.7 5.8 20 5.5 0.1 3.5 3 0 0 3 3 3 0 Rx N-terminal domain HisKA_3 PF07730.13 EDO06999.1 - 0.3 11.6 0.7 18 5.9 0.4 2.8 2 0 0 2 2 2 0 Histidine kinase Glutaredoxin2_C PF04399.13 EDO06999.1 - 0.42 10.4 1.4 27 4.6 0.0 3.7 4 0 0 4 4 4 0 Glutaredoxin 2, C terminal domain DUF4618 PF15397.6 EDO06999.1 - 0.76 9.1 4.1 1.2 8.5 1.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) VESA1_N PF12785.7 EDO07000.1 - 6.3e-225 747.3 22.8 6.3e-225 747.3 22.8 2.7 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 Baculo_PEP_C PF04513.12 EDO07000.1 - 0.026 14.6 6.8 2.1 8.4 0.0 4.0 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus PTS_IIA PF02255.16 EDO07000.1 - 0.095 12.8 0.5 19 5.4 0.0 2.4 2 0 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIA subunit Spc7 PF08317.11 EDO07000.1 - 9 5.1 5.3 0.94 8.3 0.7 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein F-box-like_2 PF13013.6 EDO07001.1 - 1.4e-11 44.3 6.3 0.0005 20.0 0.1 5.2 2 2 2 5 5 5 5 F-box-like domain DUF2770 PF10968.8 EDO07001.1 - 0.023 14.6 0.5 1.9 8.5 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2770) F-box-like_2 PF13013.6 EDO07002.1 - 0.00021 21.2 0.3 0.00043 20.2 0.3 1.5 1 1 0 1 1 1 1 F-box-like domain SporV_AA PF12164.8 EDO07003.1 - 0.12 12.7 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 Stage V sporulation protein AA EMP24_GP25L PF01105.24 EDO07004.1 - 1.5e-24 86.9 0.5 1.8e-24 86.7 0.5 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Ribonuc_red_sm PF00268.21 EDO07005.1 - 1.9e-40 139.1 0.6 3.5e-40 138.2 0.6 1.4 1 1 0 1 1 1 1 Ribonucleotide reductase, small chain EIIC-GAT PF03611.14 EDO07007.1 - 0.065 12.3 0.0 0.091 11.8 0.0 1.1 1 0 0 1 1 1 0 PTS system sugar-specific permease component Exo_endo_phos PF03372.23 EDO07008.1 - 1.3e-08 34.6 0.0 2.7e-08 33.6 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PDEase_I PF00233.19 EDO07010.1 - 1.7e-64 217.8 0.7 3.2e-64 216.9 0.7 1.5 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 EDO07010.1 - 0.0024 18.1 0.2 0.01 16.0 0.2 2.0 1 1 1 2 2 2 1 HD domain RRM_1 PF00076.22 EDO07011.1 - 1.2e-25 89.1 0.0 6.5e-16 57.9 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WW PF00397.26 EDO07011.1 - 9.2e-07 28.8 4.0 9.2e-07 28.8 4.0 1.8 2 0 0 2 2 2 1 WW domain RRM_7 PF16367.5 EDO07011.1 - 0.00016 21.7 0.0 0.016 15.3 0.0 2.7 2 1 0 2 2 2 1 RNA recognition motif DUF1866 PF08952.11 EDO07011.1 - 0.00038 20.3 0.0 0.00087 19.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1866) Nup35_RRM_2 PF14605.6 EDO07011.1 - 0.0077 16.2 0.0 0.02 14.9 0.0 1.7 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.13 EDO07011.1 - 0.0099 15.8 0.0 0.043 13.8 0.0 2.0 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RNA_bind PF08675.11 EDO07011.1 - 0.01 15.8 0.1 0.065 13.3 0.1 2.2 1 1 0 1 1 1 0 RNA binding domain Glyco_hyd_101C PF17451.2 EDO07011.1 - 0.038 14.3 0.7 0.071 13.4 0.7 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase 101 beta sandwich domain PQQ PF01011.21 EDO07011.1 - 0.082 12.9 0.0 0.24 11.4 0.0 1.8 1 0 0 1 1 1 0 PQQ enzyme repeat Meiosis_expr PF15163.6 EDO07011.1 - 0.19 12.4 0.8 0.42 11.3 0.8 1.5 1 0 0 1 1 1 0 Meiosis-expressed MA3 PF02847.17 EDO07012.1 - 7.9e-23 80.6 2.0 1.7e-22 79.5 2.0 1.6 1 0 0 1 1 1 1 MA3 domain MIF4G PF02854.19 EDO07012.1 - 2.3e-08 33.9 0.5 2.3e-08 33.9 0.5 2.5 3 0 0 3 3 3 1 MIF4G domain DUF5523 PF17661.1 EDO07012.1 - 0.0029 17.3 0.3 0.0045 16.7 0.3 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5523) CNOT1_CAF1_bind PF16415.5 EDO07012.1 - 0.067 12.6 0.6 0.21 10.9 0.1 2.1 3 0 0 3 3 3 0 CCR4-NOT transcription complex subunit 1 CAF1-binding domain Ribosomal_S8 PF00410.19 EDO07013.1 - 5e-17 62.0 0.0 6e-17 61.8 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S8 Ras PF00071.22 EDO07014.1 - 2.1e-57 193.3 0.5 2.5e-57 193.0 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO07014.1 - 2.6e-35 121.3 0.4 3.8e-35 120.7 0.4 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO07014.1 - 1.9e-12 47.0 0.1 2.3e-12 46.7 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EDO07014.1 - 1.7e-07 31.3 0.2 3.1e-07 30.5 0.2 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDO07014.1 - 0.00026 20.6 0.1 0.016 14.8 0.1 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EDO07014.1 - 0.00067 19.1 0.0 0.00093 18.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EDO07014.1 - 0.0019 18.1 0.4 0.9 9.4 0.1 2.2 1 1 1 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EDO07014.1 - 0.0046 16.3 0.1 0.0058 16.0 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 EDO07014.1 - 0.019 14.5 0.1 0.035 13.6 0.1 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B TniB PF05621.11 EDO07014.1 - 0.059 12.8 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein DUF2460 PF09343.10 EDO07014.1 - 0.092 12.2 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 2217 (DUF2460) AAA_21 PF13304.6 EDO07014.1 - 0.14 12.0 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Cyclin_N PF00134.23 EDO07015.1 - 3.4e-08 33.3 0.3 4.3e-06 26.5 0.0 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain Herpes_UL37_2 PF07413.11 EDO07015.1 - 0.037 13.3 0.0 0.053 12.8 0.0 1.2 1 0 0 1 1 1 0 Betaherpesvirus immediate-early glycoprotein UL37 Dsh_C PF12316.8 EDO07015.1 - 5 7.5 11.8 8.1 6.8 11.8 1.3 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal MCM6_C PF18263.1 EDO07016.1 - 7.7e-06 26.1 0.0 8.3e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain zf-RING_2 PF13639.6 EDO07017.1 - 5.1e-12 45.9 4.2 5.1e-12 45.9 4.2 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDO07017.1 - 1e-08 34.9 4.2 1e-08 34.9 4.2 2.6 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EDO07017.1 - 4.9e-08 33.1 7.9 4.9e-08 33.1 7.9 2.5 3 1 0 3 3 2 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EDO07017.1 - 1.8e-07 30.7 0.8 1.8e-07 30.7 0.8 2.6 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4 PF00097.25 EDO07017.1 - 7.5e-06 25.7 2.9 7.5e-06 25.7 2.9 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDO07017.1 - 6.7e-05 22.8 0.1 6.7e-05 22.8 0.1 2.2 2 1 0 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EDO07017.1 - 8.4e-05 22.6 2.0 0.00019 21.4 2.0 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 EDO07017.1 - 0.00078 19.6 3.2 0.00078 19.6 3.2 2.0 2 1 0 2 2 1 1 FANCL C-terminal domain zf-C3HC4_3 PF13920.6 EDO07017.1 - 0.00097 19.0 11.1 0.0094 15.8 2.6 2.5 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDO07017.1 - 0.018 15.0 2.0 0.018 15.0 2.0 2.6 2 1 0 2 2 2 0 zinc-RING finger domain PHD_Oberon PF07227.11 EDO07017.1 - 0.086 12.7 0.1 0.086 12.7 0.1 2.0 2 1 0 2 2 2 0 PHD - plant homeodomain finger protein Prok-RING_4 PF14447.6 EDO07017.1 - 0.16 11.9 13.8 0.081 12.8 4.4 3.0 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING-like PF08746.11 EDO07017.1 - 0.27 11.6 3.4 0.84 10.0 3.4 1.9 1 1 0 1 1 1 0 RING-like domain Rad50_zn_hook PF04423.14 EDO07017.1 - 0.28 11.0 5.0 0.42 10.5 1.9 2.7 2 1 0 2 2 2 0 Rad50 zinc hook motif zinc_ribbon_16 PF17034.5 EDO07017.1 - 0.28 11.4 3.1 0.64 10.2 1.5 2.2 1 1 1 2 2 2 0 Zinc-ribbon like family PHD PF00628.29 EDO07017.1 - 2.6 8.0 13.2 1.1 9.2 3.7 3.0 2 1 0 2 2 2 0 PHD-finger zf-P11 PF03854.14 EDO07017.1 - 3.7 7.3 8.8 0.26 11.0 0.5 2.5 2 1 0 2 2 2 0 P-11 zinc finger UTP25 PF06862.12 EDO07018.1 - 6.9e-112 374.6 6.3 2.2e-111 373.0 6.3 1.7 1 1 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Helicase_C PF00271.31 EDO07018.1 - 0.068 13.5 0.0 0.6 10.5 0.0 2.3 2 0 0 2 2 2 0 Helicase conserved C-terminal domain tRNA-synt_1g PF09334.11 EDO07019.1 - 9.3e-70 235.3 0.1 4.7e-34 117.8 0.0 2.9 1 1 1 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EDO07019.1 - 2.8e-10 39.1 0.1 0.00028 19.3 0.2 4.0 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EDO07019.1 - 6.2e-07 29.1 0.4 7.3e-06 25.5 0.1 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain POTRA PF07244.15 EDO07019.1 - 0.044 14.4 0.1 0.2 12.3 0.0 2.1 2 0 0 2 2 2 0 Surface antigen variable number repeat Mito_carr PF00153.27 EDO07021.1 - 1.4e-05 24.9 0.1 0.00084 19.2 0.0 2.4 2 1 0 2 2 2 2 Mitochondrial carrier protein Ph1570 PF09638.10 EDO07023.1 - 0.031 14.1 0.2 0.07 13.0 0.1 1.5 1 1 0 1 1 1 0 Ph1570 protein HAUS2 PF15003.6 EDO07023.1 - 0.032 14.0 0.3 0.081 12.7 0.1 1.6 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 2 PrmA PF06325.13 EDO07023.1 - 0.093 12.1 0.6 0.31 10.4 0.2 1.6 1 1 1 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) RRM_1 PF00076.22 EDO07024.1 - 2.6e-30 104.0 0.6 3.7e-15 55.5 0.2 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDO07024.1 - 1.2e-05 24.9 0.0 0.004 16.7 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EDO07024.1 - 4.3e-05 23.5 0.5 0.18 11.9 0.1 2.4 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.6 EDO07024.1 - 0.0025 17.8 0.1 0.011 15.7 0.0 1.9 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EDO07024.1 - 0.0041 17.2 0.0 0.01 15.9 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif DbpA PF03880.15 EDO07024.1 - 0.086 12.8 0.3 0.21 11.6 0.0 1.7 2 0 0 2 2 2 0 DbpA RNA binding domain EspA PF03433.13 EDO07025.1 - 0.0029 17.5 0.3 0.0055 16.6 0.1 1.5 1 1 0 1 1 1 1 EspA-like secreted protein Mod_r PF07200.13 EDO07025.1 - 0.05 13.7 0.3 0.073 13.2 0.3 1.3 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein HutP PF09021.11 EDO07025.1 - 0.17 12.2 0.1 0.33 11.3 0.0 1.5 2 0 0 2 2 2 0 HutP FA_desaturase_2 PF03405.14 EDO07026.1 - 0.06 12.2 0.1 0.08 11.8 0.1 1.1 1 0 0 1 1 1 0 Fatty acid desaturase DnaJ PF00226.31 EDO07027.1 - 2.7e-16 59.4 0.5 2.7e-16 59.4 0.5 2.0 2 0 0 2 2 2 1 DnaJ domain zf-C2H2_jaz PF12171.8 EDO07027.1 - 2.8e-09 37.0 0.6 2.8e-09 37.0 0.6 2.5 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDO07027.1 - 1.9e-08 34.4 0.7 1.9e-08 34.4 0.7 2.2 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EDO07027.1 - 0.00018 22.0 0.1 0.001 19.7 0.1 2.4 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 EDO07027.1 - 0.00024 21.4 1.6 0.00048 20.4 0.3 2.3 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 EDO07027.1 - 0.00061 19.7 0.5 0.0018 18.2 0.2 2.0 2 0 0 2 2 2 1 C2H2-type zinc finger Glyco_hydro_20 PF00728.22 EDO07027.1 - 0.049 13.0 4.3 0.017 14.6 1.2 1.5 1 1 0 1 1 1 0 Glycosyl hydrolase family 20, catalytic domain Zf_RING PF16744.5 EDO07027.1 - 0.15 12.1 1.4 0.87 9.7 0.3 2.8 2 0 0 2 2 2 0 KIAA1045 RING finger EutA PF06277.11 EDO07027.1 - 0.59 8.9 3.6 1.1 8.0 3.6 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation protein EutA zf-DBF PF07535.12 EDO07027.1 - 3 8.0 7.1 0.17 12.0 0.5 2.5 2 0 0 2 2 2 0 DBF zinc finger Peptidase_C97 PF05903.14 EDO07028.1 - 2e-31 108.9 0.3 7e-31 107.1 0.1 1.9 2 0 0 2 2 2 1 PPPDE putative peptidase domain PDDEXK_6 PF04720.12 EDO07028.1 - 0.11 12.5 1.5 0.17 11.8 1.5 1.3 1 0 0 1 1 1 0 PDDEXK-like family of unknown function RRM_1 PF00076.22 EDO07029.1 - 4e-36 122.7 0.0 1.3e-18 66.6 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDO07029.1 - 0.0017 17.9 0.0 0.036 13.7 0.0 2.1 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EDO07029.1 - 0.074 13.1 0.1 7.6 6.6 0.0 2.3 2 0 0 2 2 2 0 RNA binding motif RHSP PF07999.11 EDO07029.1 - 0.13 11.0 0.1 0.95 8.2 0.0 1.9 2 0 0 2 2 2 0 Retrotransposon hot spot protein Myb_DNA-bind_5 PF13873.6 EDO07029.1 - 0.19 11.8 1.0 16 5.7 0.4 2.4 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Thioredoxin PF00085.20 EDO07030.1 - 1.2e-07 31.6 0.5 3.7e-07 30.1 0.1 1.9 2 0 0 2 2 2 1 Thioredoxin Phosducin PF02114.16 EDO07030.1 - 4.7e-07 29.0 0.4 6e-07 28.7 0.4 1.1 1 0 0 1 1 1 1 Phosducin B277 PF17623.2 EDO07030.1 - 0.078 12.1 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function Auto_anti-p27 PF06677.12 EDO07031.1 - 1.2e-11 44.6 4.8 1.8e-11 44.0 4.8 1.3 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Ribosomal_L37ae PF01780.19 EDO07031.1 - 0.032 14.3 0.6 0.056 13.5 0.6 1.3 1 0 0 1 1 1 0 Ribosomal L37ae protein family Peptidase_M24 PF00557.24 EDO07032.1 - 7e-52 176.2 0.0 8.5e-52 175.9 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 EDO07032.1 - 5.1e-10 39.5 9.2 9.6e-10 38.6 9.2 1.4 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 EDO07032.1 - 0.28 11.3 7.6 0.79 9.9 7.6 1.7 1 0 0 1 1 1 0 MYND finger RMI1_N PF08585.12 EDO07033.1 - 2.3e-10 40.6 0.0 5e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 RecQ mediated genome instability protein BIR PF00653.21 EDO07033.1 - 0.037 14.7 0.2 0.14 12.8 0.1 2.0 2 0 0 2 2 2 0 Inhibitor of Apoptosis domain NTP_transf_2 PF01909.23 EDO07034.1 - 2e-06 28.0 0.0 4.3e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EDO07034.1 - 0.0061 16.6 0.0 0.025 14.7 0.0 2.1 2 0 0 2 2 2 1 Polymerase beta, Nucleotidyltransferase Cpn60_TCP1 PF00118.24 EDO07035.1 - 9.5e-93 311.4 12.0 1.7e-92 310.6 12.0 1.3 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family PAP2 PF01569.21 EDO07036.1 - 0.017 14.9 2.5 0.017 14.9 2.5 2.0 1 1 1 2 2 2 0 PAP2 superfamily Ribosomal_S5 PF00333.20 EDO07037.1 - 3.2e-15 55.8 0.1 6.9e-15 54.8 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EDO07037.1 - 5.8e-12 44.9 0.0 1.6e-11 43.5 0.0 1.8 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Histone PF00125.24 EDO07040.1 - 1.9e-18 67.1 0.8 2.3e-18 66.8 0.8 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID_20kDa PF03847.13 EDO07040.1 - 0.0035 17.8 0.4 0.0053 17.2 0.0 1.4 2 0 0 2 2 2 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.23 EDO07040.1 - 0.005 17.1 0.1 0.01 16.1 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone RRM_1 PF00076.22 EDO07041.1 - 1.9e-20 72.5 0.0 2.5e-20 72.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDO07041.1 - 0.00015 21.3 0.0 0.0002 21.0 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDO07041.1 - 0.0029 17.4 0.0 0.0039 17.0 0.0 1.2 1 0 0 1 1 1 1 Occluded RNA-recognition motif DUF1866 PF08952.11 EDO07041.1 - 0.034 14.0 0.0 0.042 13.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1866) RRM_3 PF08777.11 EDO07041.1 - 0.11 12.5 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif Skp1 PF01466.19 EDO07042.1 - 9.5e-27 92.9 1.2 1.7e-26 92.1 1.2 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 EDO07042.1 - 6.6e-12 45.4 0.0 1.6e-11 44.2 0.0 1.7 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain Ribosomal_L24e PF01246.20 EDO07044.1 - 3.4e-32 110.5 4.6 3.4e-32 110.5 4.6 1.9 2 0 0 2 2 2 1 Ribosomal protein L24e zf-FCS PF06467.14 EDO07044.1 - 0.052 13.5 3.1 0.1 12.6 2.8 1.7 1 1 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif SYF2 PF08231.12 EDO07045.1 - 5.6e-30 104.9 12.7 8.8e-30 104.2 12.7 1.3 1 0 0 1 1 1 1 SYF2 splicing factor Pro_isomerase PF00160.21 EDO07045.1 - 6.2e-22 78.6 0.1 1.2e-21 77.6 0.1 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD A_deamin PF02137.18 EDO07045.1 - 0.057 12.9 0.4 0.088 12.2 0.4 1.2 1 0 0 1 1 1 0 Adenosine-deaminase (editase) domain IMPDH PF00478.25 EDO07046.1 - 3.7e-126 420.8 3.6 4.3e-126 420.6 3.6 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EDO07046.1 - 2.2e-14 53.6 1.0 2.3e-06 27.3 0.5 3.2 3 0 0 3 3 3 3 Nitronate monooxygenase FMN_dh PF01070.18 EDO07046.1 - 8.7e-14 51.3 4.7 4.1e-12 45.8 3.3 2.9 2 1 0 2 2 2 1 FMN-dependent dehydrogenase CBS PF00571.28 EDO07046.1 - 2.8e-13 50.1 0.2 1.3e-05 25.5 0.1 3.3 3 0 0 3 3 3 2 CBS domain His_biosynth PF00977.21 EDO07046.1 - 1.4e-05 24.7 0.6 0.088 12.2 0.0 2.5 1 1 1 2 2 2 2 Histidine biosynthesis protein Glu_synthase PF01645.17 EDO07046.1 - 6.1e-05 22.3 2.1 6.1e-05 22.3 2.1 1.8 1 1 1 2 2 2 1 Conserved region in glutamate synthase NanE PF04131.14 EDO07046.1 - 6.1e-05 22.3 1.1 0.0021 17.3 0.9 3.3 1 1 1 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase DHO_dh PF01180.21 EDO07046.1 - 0.00024 20.4 4.0 0.0011 18.2 0.7 2.5 1 1 1 2 2 2 1 Dihydroorotate dehydrogenase ThiG PF05690.14 EDO07046.1 - 0.0019 17.5 4.8 0.0042 16.4 1.8 2.6 2 1 1 3 3 3 1 Thiazole biosynthesis protein ThiG G3P_antiterm PF04309.12 EDO07046.1 - 0.064 12.7 0.2 2.9 7.3 0.0 2.8 2 1 1 3 3 3 0 Glycerol-3-phosphate responsive antiterminator QRPTase_C PF01729.19 EDO07046.1 - 0.066 13.0 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain Aldolase PF01081.19 EDO07046.1 - 0.29 10.5 1.9 2 7.8 0.1 2.7 3 0 0 3 3 3 0 KDPG and KHG aldolase DEAD PF00270.29 EDO07047.1 - 2.2e-30 105.7 0.4 5.1e-30 104.5 0.1 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO07047.1 - 8.3e-22 77.6 0.1 4.4e-21 75.3 0.0 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO07047.1 - 1.2e-08 35.1 0.0 2.2e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 EDO07047.1 - 0.0055 15.5 0.0 0.78 8.5 0.0 2.2 2 0 0 2 2 2 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_22 PF13401.6 EDO07047.1 - 0.009 16.3 0.1 0.034 14.4 0.1 1.9 1 1 0 1 1 1 1 AAA domain PhoH PF02562.16 EDO07047.1 - 0.042 13.3 0.0 0.089 12.2 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein T4SS-DNA_transf PF02534.14 EDO07047.1 - 0.08 11.7 0.0 0.23 10.2 0.0 1.7 2 0 0 2 2 2 0 Type IV secretory system Conjugative DNA transfer Prp19 PF08606.11 EDO07048.1 - 8.8e-31 105.7 1.1 2.2e-30 104.4 1.0 1.8 1 1 1 2 2 2 1 Prp19/Pso4-like WD40 PF00400.32 EDO07048.1 - 9.6e-26 89.6 10.8 3.5e-06 27.6 0.1 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO07048.1 - 1.1e-09 38.5 0.0 0.34 11.2 0.0 5.1 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain U-box PF04564.15 EDO07048.1 - 2e-07 31.0 0.0 4.2e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 U-box domain Nup160 PF11715.8 EDO07048.1 - 0.0014 17.3 1.5 0.014 14.1 1.0 2.8 1 1 1 2 2 2 1 Nucleoporin Nup120/160 zf-Nse PF11789.8 EDO07048.1 - 0.0026 17.5 1.3 0.028 14.2 0.2 2.6 3 0 0 3 3 3 1 Zinc-finger of the MIZ type in Nse subunit Hira PF07569.11 EDO07048.1 - 0.0033 17.2 0.0 0.39 10.4 0.0 2.5 1 1 1 2 2 2 1 TUP1-like enhancer of split Frtz PF11768.8 EDO07048.1 - 0.0035 15.7 0.0 2.5 6.3 0.0 3.0 2 1 1 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz eIF2A PF08662.11 EDO07048.1 - 0.0088 15.9 0.0 3.6 7.4 0.0 3.6 1 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A VID27 PF08553.10 EDO07048.1 - 0.013 14.5 0.0 1.2 8.1 0.0 2.5 2 1 1 3 3 3 0 VID27 C-terminal WD40-like domain PspB PF06667.12 EDO07050.1 - 0.0017 18.3 1.3 0.03 14.4 0.0 2.2 2 0 0 2 2 2 1 Phage shock protein B MetOD2 PF18548.1 EDO07050.1 - 0.004 17.2 0.4 0.68 10.1 0.0 2.2 2 0 0 2 2 2 1 Metanogen output domain 2 Gp-FAR-1 PF05823.12 EDO07050.1 - 0.0053 17.1 0.0 0.12 12.7 0.0 2.0 2 0 0 2 2 2 1 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Rootletin PF15035.6 EDO07050.1 - 0.012 15.7 2.0 0.016 15.3 2.0 1.1 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Lebercilin PF15619.6 EDO07050.1 - 0.012 15.3 3.5 1 9.0 0.3 2.1 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Matrilin_ccoil PF10393.9 EDO07050.1 - 0.018 14.9 0.3 0.26 11.2 0.0 2.1 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin YqcI_YcgG PF08892.11 EDO07050.1 - 0.02 14.8 0.1 0.037 13.9 0.0 1.5 1 1 0 1 1 1 0 YqcI/YcgG family RYDR_ITPR PF01365.21 EDO07050.1 - 0.023 14.1 0.0 0.029 13.8 0.0 1.1 1 0 0 1 1 1 0 RIH domain DUF1664 PF07889.12 EDO07050.1 - 0.028 14.5 0.3 1 9.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) SF-assemblin PF06705.11 EDO07050.1 - 0.032 13.6 0.9 2.5 7.4 0.2 2.0 2 0 0 2 2 2 0 SF-assemblin/beta giardin DUF4795 PF16043.5 EDO07050.1 - 0.038 13.6 1.3 0.75 9.4 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) CLZ PF16526.5 EDO07050.1 - 0.04 14.3 0.2 6.1 7.3 0.0 2.3 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels PspA_IM30 PF04012.12 EDO07050.1 - 0.043 13.4 0.1 0.6 9.6 0.0 2.0 2 0 0 2 2 2 0 PspA/IM30 family Csm1_N PF18504.1 EDO07050.1 - 0.044 14.1 0.5 5.9 7.3 0.1 2.2 2 0 0 2 2 2 0 Csm1 N-terminal domain Ada3 PF10198.9 EDO07050.1 - 0.045 13.9 1.1 0.084 13.0 1.1 1.6 1 1 0 1 1 1 0 Histone acetyltransferases subunit 3 PriC PF07445.12 EDO07050.1 - 0.058 13.3 2.8 0.085 12.8 2.8 1.2 1 0 0 1 1 1 0 Primosomal replication protein priC BLOC1_2 PF10046.9 EDO07050.1 - 0.06 13.7 0.6 10 6.5 0.1 2.1 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4407 PF14362.6 EDO07050.1 - 0.064 12.6 0.2 0.078 12.3 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DivIC PF04977.15 EDO07050.1 - 0.084 12.7 2.0 3 7.7 0.1 2.2 2 0 0 2 2 2 0 Septum formation initiator HalX PF08663.10 EDO07050.1 - 0.085 13.2 0.6 0.89 9.9 0.0 2.6 2 1 0 2 2 2 0 HalX domain DUF2721 PF11026.8 EDO07050.1 - 0.11 12.4 1.0 5.8 6.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) DUF4140 PF13600.6 EDO07050.1 - 0.12 12.8 0.2 5.2 7.6 0.0 2.1 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) ABC_tran_CTD PF16326.5 EDO07050.1 - 0.13 12.6 2.5 0.63 10.3 0.3 2.3 1 1 0 2 2 2 0 ABC transporter C-terminal domain DUF4191 PF13829.6 EDO07050.1 - 0.2 10.9 0.3 2.4 7.4 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) HAUS6_N PF14661.6 EDO07050.1 - 0.4 10.2 3.0 1.1 8.8 0.1 2.0 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus ZapB PF06005.12 EDO07050.1 - 0.53 10.8 4.4 1.7 9.1 0.5 2.2 1 1 1 2 2 2 0 Cell division protein ZapB DASH_Dam1 PF08653.10 EDO07050.1 - 0.61 9.9 2.2 29 4.5 0.2 2.8 2 1 1 3 3 3 0 DASH complex subunit Dam1 TPR_MLP1_2 PF07926.12 EDO07050.1 - 0.71 9.9 5.6 2.9 7.9 0.9 2.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein ADIP PF11559.8 EDO07050.1 - 0.79 9.8 5.9 6.3 6.9 3.9 2.0 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding SF3b1 PF08920.10 EDO07051.1 - 1.4e-22 80.4 0.8 4.3e-22 78.8 0.8 1.8 1 0 0 1 1 1 1 Splicing factor 3B subunit 1 HEAT PF02985.22 EDO07051.1 - 1.2e-13 50.0 3.0 0.2 12.0 0.1 9.3 9 0 0 9 9 9 2 HEAT repeat HEAT_EZ PF13513.6 EDO07051.1 - 1.9e-10 41.0 5.2 0.024 15.1 0.0 7.4 8 1 1 9 9 9 3 HEAT-like repeat HEAT_2 PF13646.6 EDO07051.1 - 1.1e-09 38.5 9.7 0.027 14.9 0.1 7.9 4 2 4 8 8 8 3 HEAT repeats Adaptin_N PF01602.20 EDO07051.1 - 1.5e-05 23.8 2.4 0.00075 18.2 0.0 3.2 3 1 0 3 3 3 2 Adaptin N terminal region Dopey_N PF04118.14 EDO07051.1 - 0.00081 18.6 0.8 0.26 10.3 0.0 3.6 4 0 0 4 4 4 1 Dopey, N-terminal CLASP_N PF12348.8 EDO07051.1 - 0.0028 17.3 0.2 0.85 9.1 0.0 3.4 3 0 0 3 3 3 1 CLASP N terminal Arm PF00514.23 EDO07051.1 - 0.0073 16.3 1.0 9.1 6.5 0.3 5.0 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat UME PF08064.13 EDO07051.1 - 0.018 15.0 3.4 7.9 6.5 0.0 5.2 5 2 1 6 6 6 0 UME (NUC010) domain Vac14_Fab1_bd PF12755.7 EDO07051.1 - 0.14 12.8 0.2 31 5.3 0.0 3.7 2 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region Cpn60_TCP1 PF00118.24 EDO07053.1 - 2.1e-154 514.8 8.4 2.4e-154 514.6 8.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family ATP-synt_10 PF05176.14 EDO07054.1 - 0.24 10.6 0.0 0.48 9.6 0.0 1.5 2 0 0 2 2 2 0 ATP10 protein DUF572 PF04502.13 EDO07055.1 - 1.4e-33 116.9 3.9 9.9e-31 107.6 0.2 2.1 2 0 0 2 2 2 2 Family of unknown function (DUF572) Cpn60_TCP1 PF00118.24 EDO07057.1 - 5.9e-82 275.9 4.9 9e-82 275.2 4.9 1.3 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PAP_assoc PF03828.19 EDO07059.1 - 0.16 12.2 1.1 0.78 10.0 1.1 2.3 1 1 0 1 1 1 0 Cid1 family poly A polymerase Thioredoxin PF00085.20 EDO07060.1 - 0.0027 17.7 0.0 0.005 16.8 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin WD40 PF00400.32 EDO07061.1 - 3.7e-25 87.7 5.9 4e-06 27.5 0.0 7.4 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO07061.1 - 2.9e-13 49.9 0.1 0.00035 20.8 0.0 5.1 4 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain TFIIIC_delta PF12657.7 EDO07061.1 - 2.7e-05 24.2 2.3 0.088 12.7 0.0 4.5 3 1 1 4 4 4 2 Transcription factor IIIC subunit delta N-term Ge1_WD40 PF16529.5 EDO07061.1 - 2.8e-05 23.3 0.0 0.19 10.6 0.0 3.4 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EDO07061.1 - 0.0033 17.3 0.0 5.3 6.9 0.0 3.9 3 1 1 4 4 4 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 EDO07061.1 - 0.004 17.0 0.6 45 4.1 0.1 4.9 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 EDO07061.1 - 0.025 13.6 0.0 1.3 8.0 0.0 2.2 2 0 0 2 2 2 0 Coatomer WD associated region GAGA_bind PF06217.12 EDO07061.1 - 7.5 6.7 8.3 5.9 7.1 0.7 2.3 2 0 0 2 2 2 0 GAGA binding protein-like family DNA_pol_B PF00136.21 EDO07062.1 - 9.4e-98 327.9 4.1 3e-96 322.9 3.9 2.6 2 1 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EDO07062.1 - 2.8e-21 76.0 4.4 5.2e-21 75.2 4.4 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 EDO07062.1 - 2e-13 50.2 10.6 5.2e-13 48.9 10.6 1.8 1 0 0 1 1 1 1 DNA polymerase alpha subunit p180 N terminal Swm2 PF17083.5 EDO07062.1 - 2.1 8.4 6.9 24 4.9 0.0 3.6 3 0 0 3 3 3 0 Nucleolar protein Swm2 RRM_1 PF00076.22 EDO07063.1 - 1.6e-12 47.0 0.2 0.0021 17.8 0.0 5.4 3 2 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDO07063.1 - 0.062 13.2 0.0 6.2 6.8 0.0 2.6 2 0 0 2 2 2 0 Occluded RNA-recognition motif Ribosom_S12_S23 PF00164.25 EDO07064.1 - 1.5e-27 95.4 0.8 3.6e-27 94.2 0.4 1.7 3 0 0 3 3 3 1 Ribosomal protein S12/S23 EMP24_GP25L PF01105.24 EDO07065.1 - 1.8e-36 125.8 3.4 2.1e-36 125.6 3.4 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF2569 PF10754.9 EDO07065.1 - 0.033 14.6 0.7 0.033 14.6 0.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) Filamin PF00630.19 EDO07065.1 - 0.041 14.7 0.9 0.27 12.1 0.1 2.1 2 0 0 2 2 2 0 Filamin/ABP280 repeat Pneumo_M2 PF07380.11 EDO07065.1 - 0.054 13.8 0.4 0.12 12.6 0.4 1.6 1 0 0 1 1 1 0 Pneumovirus M2 protein MCM PF00493.23 EDO07066.1 - 3.6e-87 291.1 0.0 5.4e-87 290.6 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDO07066.1 - 3.7e-21 75.3 0.2 1.8e-20 73.1 0.0 2.2 2 0 0 2 2 2 1 MCM OB domain MCM_lid PF17855.1 EDO07066.1 - 4.8e-12 46.1 4.5 1.7e-11 44.4 3.0 2.8 2 1 0 2 2 2 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EDO07066.1 - 1.6e-08 34.2 0.1 0.00071 19.0 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDO07066.1 - 2.9e-07 30.6 0.0 1.8e-06 28.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EDO07066.1 - 5.6e-06 26.2 0.0 1.9e-05 24.5 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 EDO07066.1 - 0.00011 22.6 0.0 0.0014 19.1 0.0 2.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EDO07066.1 - 0.0049 16.6 0.0 4.9 6.8 0.0 3.0 3 0 0 3 3 3 2 Sigma-54 interaction domain AAA_16 PF13191.6 EDO07066.1 - 0.0098 16.3 0.7 0.25 11.7 0.0 3.2 2 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EDO07066.1 - 0.059 13.6 0.1 0.93 9.8 0.1 2.7 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EDO07066.1 - 0.11 12.0 0.0 0.27 10.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region UQ_con PF00179.26 EDO07067.1 - 3.4e-45 153.1 0.0 3.8e-45 153.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EDO07067.1 - 0.004 17.0 0.1 0.0075 16.1 0.1 1.5 1 1 0 1 1 1 1 UEV domain Prok-E2_B PF14461.6 EDO07067.1 - 0.01 15.6 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 EDO07067.1 - 0.051 13.9 0.4 0.06 13.6 0.4 1.5 1 1 0 1 1 1 0 RWD domain Peptidase_M28 PF04389.17 EDO07068.1 - 1.3e-07 31.5 0.0 2.2e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 DUF1411 PF07199.11 EDO07069.1 - 0.023 14.4 0.1 0.11 12.2 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1411) DEFB136 PF17333.2 EDO07069.1 - 0.091 12.7 0.1 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 Beta defensin 136 DUF1411 PF07199.11 EDO07070.1 - 8.1e-05 22.4 0.1 0.00018 21.2 0.1 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF1411) CCSAP PF15748.5 EDO07071.1 - 0.14 12.3 2.0 0.2 11.8 2.0 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated PHD PF00628.29 EDO07072.1 - 0.005 16.7 5.2 0.083 12.8 5.2 3.0 1 1 0 1 1 1 1 PHD-finger Zf_RING PF16744.5 EDO07072.1 - 0.057 13.5 2.8 0.096 12.8 0.2 2.7 2 0 0 2 2 2 0 KIAA1045 RING finger zf-ANAPC11 PF12861.7 EDO07072.1 - 0.17 12.0 1.0 0.42 10.7 1.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger PHD_4 PF16866.5 EDO07072.1 - 3.6 7.7 6.2 1.2 9.3 2.0 2.5 2 0 0 2 2 2 0 PHD-finger FAM76 PF16046.5 EDO07073.1 - 0.15 11.4 0.5 0.21 10.9 0.5 1.2 1 0 0 1 1 1 0 FAM76 protein PHD PF00628.29 EDO07074.1 - 4.2e-09 36.1 10.0 4.2e-09 36.1 10.0 2.6 2 1 0 2 2 1 1 PHD-finger zf-C3HC4_3 PF13920.6 EDO07074.1 - 2.5e-08 33.7 6.5 2.5e-08 33.7 6.5 2.7 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDO07074.1 - 2.7e-08 34.0 10.1 2.7e-08 34.0 10.1 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EDO07074.1 - 1.4e-07 31.3 9.2 1.4e-07 31.3 9.2 3.0 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDO07074.1 - 3.9e-07 29.8 7.6 3.9e-07 29.8 7.6 3.2 2 1 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDO07074.1 - 2.6e-06 27.4 2.9 2.6e-06 27.4 2.9 3.7 2 2 1 3 3 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EDO07074.1 - 2.5e-05 24.1 8.0 2.5e-05 24.1 8.0 2.5 4 0 0 4 4 3 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EDO07074.1 - 0.0003 20.6 7.9 0.0003 20.6 7.9 2.8 4 0 0 4 4 3 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EDO07074.1 - 0.00047 20.4 9.3 0.00047 20.4 9.3 2.9 2 1 0 2 2 2 1 RING-H2 zinc finger domain zinc_ribbon_9 PF14369.6 EDO07074.1 - 0.0017 18.6 0.9 0.0017 18.6 0.9 2.5 2 0 0 2 2 2 1 zinc-ribbon Baculo_IE-1 PF05290.11 EDO07074.1 - 0.002 18.1 1.3 0.004 17.1 1.3 1.4 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-RING_4 PF14570.6 EDO07074.1 - 0.017 14.9 7.1 0.047 13.5 7.1 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 EDO07074.1 - 0.7 10.1 11.9 1.1 9.5 8.0 2.9 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 EDO07074.1 - 1.3 9.1 13.3 0.15 12.1 0.8 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Pyr_redox_2 PF07992.14 EDO07075.1 - 7.1e-70 235.6 5.7 1e-69 235.1 5.7 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EDO07075.1 - 5.5e-33 113.5 0.1 1.7e-32 111.9 0.1 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EDO07075.1 - 6.2e-22 77.9 5.2 3.8e-18 65.8 1.2 3.4 3 1 1 4 4 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDO07075.1 - 6e-12 45.4 3.3 9.4e-09 34.9 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDO07075.1 - 9.4e-11 41.8 1.8 3.9e-06 27.0 0.3 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EDO07075.1 - 8.5e-10 38.3 8.1 8.8e-06 25.0 0.7 3.1 3 0 0 3 3 3 3 Glucose inhibited division protein A DAO PF01266.24 EDO07075.1 - 8.8e-09 35.4 9.6 0.01 15.5 0.2 4.0 3 1 1 4 4 4 3 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EDO07075.1 - 1.3e-08 34.7 8.8 8.4e-08 32.0 0.3 3.1 2 1 1 3 3 3 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EDO07075.1 - 3.4e-08 32.6 12.3 0.00035 19.4 0.3 4.5 2 2 2 5 5 5 2 HI0933-like protein Thi4 PF01946.17 EDO07075.1 - 1.1e-06 28.1 1.8 0.0003 20.1 0.1 2.4 2 0 0 2 2 2 2 Thi4 family FAD_binding_3 PF01494.19 EDO07075.1 - 2.2e-06 27.2 2.1 0.0098 15.2 0.2 2.3 2 0 0 2 2 2 2 FAD binding domain FAD_binding_2 PF00890.24 EDO07075.1 - 2.5e-06 26.9 6.9 8.5e-05 21.8 0.4 2.7 2 1 1 3 3 3 2 FAD binding domain Lycopene_cycl PF05834.12 EDO07075.1 - 3.5e-06 26.3 1.4 0.051 12.6 0.1 3.0 3 0 0 3 3 3 2 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 EDO07075.1 - 4.7e-06 26.1 1.9 0.0019 17.6 0.3 2.5 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 EDO07075.1 - 1.3e-05 25.2 2.9 0.0025 17.7 0.2 2.4 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 EDO07075.1 - 0.00019 21.8 1.5 0.029 14.8 0.3 2.6 3 0 0 3 3 2 1 Putative NAD(P)-binding K_oxygenase PF13434.6 EDO07075.1 - 0.00044 19.5 0.1 0.0076 15.4 0.0 2.5 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) 2-Hacid_dh_C PF02826.19 EDO07075.1 - 0.0023 17.3 0.9 0.17 11.2 0.0 2.4 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain XdhC_C PF13478.6 EDO07075.1 - 0.0032 18.0 0.0 0.64 10.5 0.0 2.4 2 0 0 2 2 2 1 XdhC Rossmann domain UDPG_MGDP_dh_N PF03721.14 EDO07075.1 - 0.021 14.4 3.6 1.3 8.6 0.4 2.5 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 EDO07075.1 - 0.096 12.9 0.9 0.68 10.2 0.1 2.7 2 0 0 2 2 2 0 TrkA-N domain NAD_binding_9 PF13454.6 EDO07075.1 - 0.68 9.9 3.0 3.4 7.6 0.0 3.1 4 0 0 4 4 4 0 FAD-NAD(P)-binding Ribosomal_L27 PF01016.19 EDO07076.1 - 1.5e-26 92.2 1.5 2e-26 91.8 1.5 1.1 1 0 0 1 1 1 1 Ribosomal L27 protein FapA PF03961.13 EDO07076.1 - 0.11 11.1 0.0 0.14 10.7 0.0 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A FAD_binding_2 PF00890.24 EDO07077.1 - 1e-123 413.5 0.8 1.7e-123 412.8 0.8 1.3 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 EDO07077.1 - 5.7e-42 142.7 0.4 9e-42 142.1 0.4 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 EDO07077.1 - 1.8e-05 24.1 0.1 0.0002 20.7 0.0 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EDO07077.1 - 8.9e-05 21.7 0.4 0.032 13.3 1.1 2.7 3 0 0 3 3 3 2 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EDO07077.1 - 0.00042 19.7 0.2 0.00087 18.6 0.2 1.5 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EDO07077.1 - 0.00048 19.4 0.3 0.082 12.1 0.1 2.4 2 0 0 2 2 2 2 Thi4 family DAO PF01266.24 EDO07077.1 - 0.00085 19.0 0.6 0.006 16.2 0.5 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EDO07077.1 - 0.022 14.0 0.6 0.43 9.8 0.2 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EDO07077.1 - 0.041 12.6 0.2 0.18 10.5 0.2 2.1 3 0 0 3 3 3 0 HI0933-like protein Lycopene_cycl PF05834.12 EDO07077.1 - 0.06 12.4 0.2 0.14 11.2 0.0 1.7 2 0 0 2 2 2 0 Lycopene cyclase protein Lin0512_fam PF09585.10 EDO07077.1 - 0.073 13.1 0.1 0.67 10.0 0.2 2.3 2 0 0 2 2 2 0 Conserved hypothetical protein (Lin0512_fam) RTC PF01137.21 EDO07079.1 - 4e-12 45.8 0.0 2.5e-11 43.2 0.0 1.9 1 1 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 EDO07079.1 - 9.3e-09 35.7 0.0 1.8e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain tRNA-synt_2b PF00587.25 EDO07080.1 - 9.9e-36 123.4 0.2 1.8e-35 122.5 0.2 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EDO07080.1 - 1.5e-13 50.9 2.3 4.4e-13 49.4 2.3 1.8 1 1 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Tubulin PF00091.25 EDO07081.1 - 3.2e-68 229.8 0.0 6.5e-68 228.8 0.0 1.5 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EDO07081.1 - 1e-46 158.2 0.5 1.8e-46 157.4 0.5 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EDO07081.1 - 5.2e-06 26.8 0.0 1.3e-05 25.5 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 EDO07081.1 - 0.0022 17.2 0.0 0.0036 16.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin like SelK_SelG PF10961.8 EDO07082.1 - 0.048 14.3 0.5 30 5.3 0.0 3.3 2 0 0 2 2 2 0 Selenoprotein SelK_SelG SelP_N PF04592.14 EDO07082.1 - 8.6 5.7 28.3 1.2 8.5 22.7 2.4 1 1 1 2 2 2 0 Selenoprotein P, N terminal region DUF900 PF05990.12 EDO07083.1 - 9.9e-06 25.2 0.0 1.9e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) MCM PF00493.23 EDO07084.1 - 1.5e-94 315.3 0.0 2.3e-94 314.7 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 EDO07084.1 - 1.7e-19 70.0 0.6 3.8e-19 68.9 0.6 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_OB PF17207.3 EDO07084.1 - 3.2e-18 65.8 0.0 6.4e-18 64.8 0.0 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_N PF14551.6 EDO07084.1 - 2.7e-10 40.8 5.3 5.6e-10 39.7 0.4 2.9 3 0 0 3 3 3 1 MCM N-terminal domain Mg_chelatase PF01078.21 EDO07084.1 - 7.7e-07 28.7 1.2 5.1e-05 22.7 0.0 2.7 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EDO07084.1 - 4.1e-06 26.7 0.0 9.8e-06 25.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EDO07084.1 - 0.00054 20.0 0.0 0.0013 18.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) DEAD PF00270.29 EDO07084.1 - 0.15 11.8 0.5 0.8 9.4 0.0 2.5 4 0 0 4 4 4 0 DEAD/DEAH box helicase AAA_16 PF13191.6 EDO07084.1 - 0.16 12.3 0.7 1.8 8.9 0.2 2.6 2 1 0 3 3 3 0 AAA ATPase domain DivIC PF04977.15 EDO07084.1 - 3.8 7.3 6.6 22 4.9 0.0 3.4 4 0 0 4 4 4 0 Septum formation initiator FH2 PF02181.23 EDO07085.1 - 1.7e-42 145.9 5.1 2.4e-42 145.4 5.1 1.2 1 0 0 1 1 1 1 Formin Homology 2 Domain PTEN_C2 PF10409.9 EDO07085.1 - 1.4e-05 24.9 0.0 6.3e-05 22.8 0.0 2.0 2 0 0 2 2 2 1 C2 domain of PTEN tumour-suppressor protein Indigoidine_A PF04227.12 EDO07086.1 - 0.12 11.7 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 Indigoidine synthase A like protein polyprenyl_synt PF00348.17 EDO07087.1 - 1.9e-46 158.2 0.1 2.6e-46 157.8 0.1 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase APG17 PF04108.12 EDO07089.1 - 0.00082 18.6 0.9 0.00082 18.6 0.9 2.6 2 0 0 2 2 2 1 Autophagy protein Apg17 Sec34 PF04136.15 EDO07089.1 - 0.0054 16.6 0.1 0.0054 16.6 0.1 4.5 3 2 1 4 4 4 1 Sec34-like family Vac14_Fab1_bd PF12755.7 EDO07089.1 - 0.026 15.1 1.2 5.8 7.6 0.2 3.1 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region DUF1351 PF07083.11 EDO07089.1 - 0.17 11.7 3.3 0.27 11.0 0.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1351) Mt_ATP-synt_B PF05405.14 EDO07089.1 - 0.87 9.2 6.3 0.27 10.8 0.4 2.6 2 1 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF445 PF04286.12 EDO07089.1 - 2 8.1 5.5 1.6 8.4 1.4 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF445) STAT_alpha PF01017.20 EDO07089.1 - 4.5 7.1 7.5 0.34 10.8 1.0 2.6 2 1 0 2 2 2 0 STAT protein, all-alpha domain zf-HIT PF04438.16 EDO07091.1 - 0.0004 20.2 13.2 0.0004 20.2 13.2 1.8 2 0 0 2 2 2 1 HIT zinc finger Uso1_p115_C PF04871.13 EDO07091.1 - 0.017 15.5 0.0 0.027 14.8 0.0 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Guanylate_cyc PF00211.20 EDO07092.1 - 2.4e-16 59.9 0.0 8.5e-07 28.8 0.0 2.3 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain GCP_N_terminal PF17681.1 EDO07092.1 - 0.059 13.0 0.0 0.48 10.0 0.1 2.1 2 0 0 2 2 2 0 Gamma tubulin complex component N-terminal SDA1 PF05285.12 EDO07093.1 - 0.041 13.3 20.8 0.096 12.1 20.8 1.5 1 0 0 1 1 1 0 SDA1 Mannosyl_trans2 PF04188.13 EDO07094.1 - 3.8e-16 59.4 28.7 4.3e-09 36.2 21.7 3.1 2 1 0 2 2 2 2 Mannosyltransferase (PIG-V) s48_45 PF07422.13 EDO07095.1 - 9.7e-05 22.9 5.5 0.069 13.7 0.1 4.1 3 1 0 3 3 3 2 Sexual stage antigen s48/45 domain DUF3912 PF13051.6 EDO07095.1 - 0.13 12.6 0.2 30 5.0 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3912) MIF4G PF02854.19 EDO07096.1 - 1.7e-27 96.5 0.8 2.1e-27 96.2 0.8 1.1 1 0 0 1 1 1 1 MIF4G domain PAN_4 PF14295.6 EDO07097.1 - 6.3 6.8 8.0 0.21 11.5 0.8 2.3 3 0 0 3 3 3 0 PAN domain WW_like PF17890.1 EDO07098.1 - 0.02 15.0 0.1 1.6 8.9 0.0 2.4 2 0 0 2 2 2 0 Peptidoglycan hydrolase LytB WW-like domain KfrB PF18790.1 EDO07098.1 - 0.022 15.0 0.3 5.4 7.3 0.0 2.4 2 0 0 2 2 2 0 KfrB protein tRNA_anti-codon PF01336.25 EDO07098.1 - 0.049 13.6 0.2 0.11 12.4 0.2 1.7 1 1 0 1 1 1 0 OB-fold nucleic acid binding domain Ribosomal_L2_C PF03947.18 EDO07101.1 - 6.8e-47 158.8 0.4 1e-46 158.2 0.4 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EDO07101.1 - 1e-26 92.7 0.0 2.3e-26 91.5 0.0 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain PAN_4 PF14295.6 EDO07102.1 - 6.4 6.8 8.0 0.21 11.5 0.8 2.3 3 0 0 3 3 3 0 PAN domain WD40 PF00400.32 EDO07103.1 - 1.3e-07 32.2 7.1 1.4 9.9 0.0 6.3 5 1 1 6 6 6 2 WD domain, G-beta repeat PQQ PF01011.21 EDO07103.1 - 0.0012 18.7 0.2 0.093 12.7 0.1 3.1 2 0 0 2 2 2 1 PQQ enzyme repeat ANAPC4_WD40 PF12894.7 EDO07103.1 - 0.0013 19.0 0.0 5 7.5 0.0 3.9 3 2 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 EDO07103.1 - 0.0083 15.1 0.0 0.026 13.4 0.0 1.7 2 0 0 2 2 2 1 Partner and localizer of BRCA2 WD40 domain PQQ_2 PF13360.6 EDO07103.1 - 0.083 12.5 0.0 0.2 11.2 0.0 1.6 2 1 0 2 2 2 0 PQQ-like domain CSD PF00313.22 EDO07103.1 - 0.15 11.9 0.3 1.5 8.7 0.0 2.5 3 0 0 3 3 3 0 'Cold-shock' DNA-binding domain s48_45 PF07422.13 EDO07104.1 - 2e-08 34.7 2.1 0.0027 18.2 0.0 4.4 5 0 0 5 5 5 2 Sexual stage antigen s48/45 domain DUF5111 PF17138.4 EDO07104.1 - 0.12 12.3 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5111) PRP38 PF03371.15 EDO07105.1 - 1.1e-57 194.6 0.1 1.3e-57 194.4 0.1 1.0 1 0 0 1 1 1 1 PRP38 family CKS PF01111.19 EDO07106.1 - 1.9e-21 76.1 0.3 4.2e-21 75.0 0.3 1.6 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit Zn_peptidase_2 PF04298.12 EDO07107.1 - 0.14 11.6 0.3 0.21 11.0 0.3 1.2 1 0 0 1 1 1 0 Putative neutral zinc metallopeptidase S1-P1_nuclease PF02265.16 EDO07108.1 - 1.7e-09 37.9 0.0 0.00019 21.4 0.0 2.2 2 0 0 2 2 2 2 S1/P1 Nuclease RabGAP-TBC PF00566.18 EDO07109.1 - 2e-50 171.5 0.5 2.8e-50 171.0 0.5 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Qn_am_d_aIV PF09100.10 EDO07109.1 - 0.086 12.7 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain IV ATP_bind_3 PF01171.20 EDO07110.1 - 1.8e-08 34.3 0.0 2.9e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 PP-loop family ATP_bind_3 PF01171.20 EDO07111.1 - 5e-14 52.5 2.3 5.8e-05 22.9 0.0 3.0 3 0 0 3 3 3 3 PP-loop family Acatn PF13000.7 EDO07112.1 - 2.5e-68 231.0 8.4 2.9e-55 187.8 2.1 3.2 1 1 2 3 3 3 3 Acetyl-coenzyme A transporter 1 MFS_1 PF07690.16 EDO07112.1 - 0.001 18.1 10.3 0.029 13.3 2.0 2.6 2 1 0 2 2 2 2 Major Facilitator Superfamily NTF2 PF02136.20 EDO07113.1 - 2.1e-11 44.5 0.2 1.2e-10 42.0 0.2 2.1 2 0 0 2 2 2 1 Nuclear transport factor 2 (NTF2) domain Cons_hypoth95 PF03602.15 EDO07115.1 - 1.1e-27 96.9 0.0 1.4e-27 96.5 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_15 PF09445.10 EDO07115.1 - 4.2e-06 26.4 0.2 6.2e-06 25.9 0.2 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_31 PF13847.6 EDO07115.1 - 9.4e-06 25.5 0.0 1.1e-05 25.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDO07115.1 - 4.6e-05 24.0 0.0 6.6e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EDO07115.1 - 0.0002 20.9 0.0 0.00031 20.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain MethyltransfD12 PF02086.15 EDO07115.1 - 0.016 14.9 0.2 0.043 13.5 0.1 1.6 1 1 0 1 1 1 0 D12 class N6 adenine-specific DNA methyltransferase PrmA PF06325.13 EDO07115.1 - 0.017 14.6 0.0 0.021 14.2 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF445 PF04286.12 EDO07117.1 - 0.24 11.1 6.4 0.29 10.9 3.6 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF445) GRASP55_65 PF04495.14 EDO07118.1 - 2.8e-52 176.7 0.1 6.2e-45 152.9 0.0 2.2 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.6 EDO07118.1 - 3.7e-09 36.8 0.0 0.00063 20.0 0.0 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 EDO07118.1 - 0.0022 17.8 0.0 0.5 10.3 0.0 2.7 3 0 0 3 3 3 2 PDZ domain WD40_3 PF15911.5 EDO07118.1 - 0.029 14.4 0.0 0.17 11.9 0.0 2.2 2 0 0 2 2 2 0 WD domain, G-beta repeat PDZ PF00595.24 EDO07118.1 - 0.043 14.2 0.0 0.74 10.2 0.0 2.4 2 0 0 2 2 2 0 PDZ domain DUF4746 PF15928.5 EDO07118.1 - 0.062 12.7 0.6 0.092 12.2 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) ECH_2 PF16113.5 EDO07119.1 - 2.3e-19 70.1 0.0 3.5e-19 69.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EDO07119.1 - 2.8e-07 30.1 0.0 3.1e-06 26.7 0.0 2.2 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase DEAD PF00270.29 EDO07120.1 - 1.2e-14 54.5 0.0 1.1e-13 51.4 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO07120.1 - 2.4e-12 47.1 0.0 1.1e-11 45.0 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain TBP PF00352.21 EDO07121.1 - 1.2e-12 47.6 0.0 1.4e-05 24.9 0.0 2.6 2 1 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EDO07121.1 - 0.12 12.5 0.0 11 6.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3378) ATP_bind_1 PF03029.17 EDO07123.1 - 4e-59 200.3 0.0 5e-52 177.1 0.1 3.0 2 1 0 2 2 2 2 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 EDO07123.1 - 5.4e-05 23.8 0.0 0.00014 22.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain CLP1_P PF16575.5 EDO07123.1 - 0.00055 19.8 0.0 0.0027 17.5 0.0 1.9 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_30 PF13604.6 EDO07123.1 - 0.0021 17.8 0.0 0.003 17.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDO07123.1 - 0.0078 16.5 0.0 0.019 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EDO07123.1 - 0.011 15.7 0.0 0.038 14.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 EDO07123.1 - 0.012 15.2 0.0 0.043 13.4 0.0 1.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain KTI12 PF08433.10 EDO07123.1 - 0.016 14.7 0.0 0.025 14.0 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 PRK PF00485.18 EDO07123.1 - 0.017 14.9 0.0 0.028 14.2 0.0 1.2 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_16 PF13191.6 EDO07123.1 - 0.027 14.9 0.0 0.046 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Type2_restr_D3 PF16902.5 EDO07123.1 - 0.027 14.4 0.2 0.08 12.9 0.0 1.8 2 0 0 2 2 2 0 Type-2 restriction enzyme D3 domain AAA_33 PF13671.6 EDO07123.1 - 0.028 14.6 0.0 0.046 13.9 0.0 1.4 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 EDO07123.1 - 0.034 13.2 0.0 0.045 12.8 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_5 PF07728.14 EDO07123.1 - 0.035 14.1 0.0 0.071 13.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) CbiA PF01656.23 EDO07123.1 - 0.042 13.9 0.0 0.059 13.4 0.0 1.3 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA PF00004.29 EDO07123.1 - 0.042 14.3 0.0 0.07 13.6 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ArsA_ATPase PF02374.15 EDO07123.1 - 0.056 12.6 0.0 0.094 11.9 0.0 1.4 1 1 0 1 1 1 0 Anion-transporting ATPase AAA_31 PF13614.6 EDO07123.1 - 0.081 12.8 0.0 0.18 11.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EDO07123.1 - 0.082 12.7 0.0 0.36 10.6 0.0 1.9 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 EDO07123.1 - 0.11 12.0 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 EDO07123.1 - 0.13 12.8 0.0 0.24 11.9 0.0 1.5 1 1 0 1 1 1 0 ABC transporter PhoH PF02562.16 EDO07123.1 - 0.13 11.7 0.0 1.6 8.2 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein AAA_17 PF13207.6 EDO07123.1 - 0.14 12.6 0.0 0.31 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EDO07123.1 - 0.18 11.5 0.0 0.3 10.8 0.0 1.5 1 1 0 1 1 1 0 AAA domain ATP-synt_Eps PF04627.13 EDO07125.1 - 6.9e-15 54.8 0.1 8.6e-15 54.5 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain GTP_EFTU PF00009.27 EDO07126.1 - 2.4e-44 151.2 0.0 4.7e-44 150.3 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EDO07126.1 - 9.1e-08 32.0 0.0 2.8e-07 30.5 0.0 1.8 2 0 0 2 2 2 1 Elongation factor G C-terminus MMR_HSR1 PF01926.23 EDO07126.1 - 4.5e-07 29.9 0.0 1.1e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 EDO07126.1 - 9.8e-06 25.6 0.0 1.9e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II AIG1 PF04548.16 EDO07126.1 - 0.0024 17.3 0.0 0.0042 16.4 0.0 1.3 1 0 0 1 1 1 1 AIG1 family Septin PF00735.18 EDO07126.1 - 0.003 16.9 0.1 0.0097 15.2 0.0 1.7 2 0 0 2 2 2 1 Septin GTP_EFTU_D2 PF03144.25 EDO07126.1 - 0.01 16.2 1.1 0.046 14.1 1.1 2.1 1 1 1 2 2 2 0 Elongation factor Tu domain 2 FeoB_N PF02421.18 EDO07126.1 - 0.025 14.1 0.0 0.093 12.3 0.0 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B F_bP_aldolase PF01116.20 EDO07126.1 - 0.029 13.8 0.0 0.051 13.0 0.0 1.3 1 0 0 1 1 1 0 Fructose-bisphosphate aldolase class-II Peptidase_C1 PF00112.23 EDO07127.1 - 8.1e-63 212.4 1.4 1.5e-62 211.5 1.4 1.4 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EDO07127.1 - 8.2e-09 35.8 5.2 1.6e-08 34.8 5.2 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EDO07127.1 - 9.2e-07 28.0 1.0 0.00014 20.8 0.1 2.4 2 1 0 2 2 2 2 Peptidase C1-like family BolA PF01722.18 EDO07128.1 - 0.18 12.1 0.0 0.27 11.5 0.0 1.3 1 0 0 1 1 1 0 BolA-like protein DASH_Duo1 PF08651.10 EDO07129.1 - 0.03 14.1 0.5 11 5.9 0.0 3.3 3 0 0 3 3 3 0 DASH complex subunit Duo1 Fib_alpha PF08702.10 EDO07129.1 - 0.43 10.7 2.7 1.2 9.3 0.1 2.8 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family MMR_HSR1 PF01926.23 EDO07130.1 - 1.5e-21 76.6 0.1 5.6e-21 74.8 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase KH_dom-like PF14714.6 EDO07130.1 - 7.4e-21 74.3 0.1 2.9e-20 72.4 0.0 2.0 3 0 0 3 3 3 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal FeoB_N PF02421.18 EDO07130.1 - 1.8e-08 34.1 0.0 3.5e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EDO07130.1 - 1.9e-05 24.6 0.3 0.0041 17.0 0.3 2.4 2 0 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 EDO07130.1 - 0.0006 19.2 0.1 0.00098 18.5 0.1 1.4 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 EDO07130.1 - 0.0021 18.1 0.3 0.42 10.6 0.7 2.4 1 1 1 2 2 2 1 Dynamin family Ras PF00071.22 EDO07130.1 - 0.049 13.2 0.1 8 6.0 0.0 2.3 2 0 0 2 2 2 0 Ras family Roc PF08477.13 EDO07130.1 - 0.052 13.8 0.1 0.39 11.0 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EDO07130.1 - 0.052 13.0 0.1 0.099 12.1 0.1 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA PF00004.29 EDO07131.1 - 4e-07 30.5 0.0 6.5e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PROCN PF08083.11 EDO07133.1 - 1.1e-227 755.5 7.0 1.6e-227 754.9 7.0 1.2 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 EDO07133.1 - 1.6e-123 410.7 0.3 2.7e-123 410.0 0.3 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 EDO07133.1 - 1.1e-88 295.1 2.7 3.6e-88 293.5 2.7 1.9 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 EDO07133.1 - 4e-83 276.8 3.7 4e-83 276.8 3.7 2.2 2 0 0 2 2 2 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 EDO07133.1 - 2.8e-71 237.8 0.0 5.3e-71 237.0 0.0 1.5 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 EDO07133.1 - 4.2e-45 152.0 0.3 9.5e-45 150.9 0.3 1.7 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 EDO07133.1 - 4.6e-29 100.8 0.0 1.6e-28 99.1 0.0 2.0 1 0 0 1 1 1 1 PROCT (NUC072) domain Proteasome PF00227.26 EDO07134.1 - 3.4e-38 131.0 0.1 7.1e-38 130.0 0.1 1.5 1 1 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDO07134.1 - 1.8e-13 49.8 0.1 3e-13 49.2 0.1 1.3 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature EKR PF10371.9 EDO07134.1 - 0.15 11.9 0.0 2.5 8.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function zf-CCCH PF00642.24 EDO07135.1 - 4.1e-12 45.7 13.6 5.5e-06 26.2 1.8 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDO07135.1 - 9.1e-06 25.6 15.4 0.0023 17.9 5.3 2.6 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 EDO07135.1 - 0.00012 22.7 3.2 0.19 12.4 0.4 2.4 2 0 0 2 2 2 2 Torus domain RRM_1 PF00076.22 EDO07135.1 - 0.0003 20.5 0.0 0.00068 19.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_4 PF18044.1 EDO07135.1 - 0.4 10.5 15.6 0.93 9.4 6.5 2.5 2 0 0 2 2 2 0 CCCH-type zinc finger Pkinase PF00069.25 EDO07137.1 - 1.2e-34 120.0 0.0 3.3e-34 118.5 0.0 1.7 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO07137.1 - 3e-24 85.7 0.0 6.1e-24 84.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO07137.1 - 0.00013 21.4 0.0 0.00023 20.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like SEP PF08059.13 EDO07139.1 - 5.5e-16 58.9 0.0 1.4e-15 57.6 0.0 1.7 2 0 0 2 2 2 1 SEP domain ubiquitin PF00240.23 EDO07139.1 - 0.00016 21.3 0.1 0.0054 16.4 0.0 2.6 3 0 0 3 3 3 1 Ubiquitin family UBX PF00789.20 EDO07139.1 - 0.14 12.4 0.0 0.25 11.6 0.0 1.3 1 0 0 1 1 1 0 UBX domain RAP1 PF07218.11 EDO07141.1 - 0.027 12.8 0.3 0.038 12.3 0.3 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PhnA_Zn_Ribbon PF08274.12 EDO07142.1 - 0.41 10.6 5.3 3 7.9 0.2 2.9 3 0 0 3 3 3 0 PhnA Zinc-Ribbon zf-ribbon_3 PF13248.6 EDO07142.1 - 3 7.4 6.8 13 5.4 0.6 2.9 3 0 0 3 3 3 0 zinc-ribbon domain Asp PF00026.23 EDO07143.1 - 6e-60 203.3 0.0 1.2e-59 202.3 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDO07143.1 - 4.4e-07 30.3 0.2 4.1e-05 23.9 0.0 2.7 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Methyltransf_8 PF05148.15 EDO07144.1 - 4.7e-30 105.1 0.5 2.6e-22 79.8 0.0 2.0 1 1 1 2 2 2 2 Hypothetical methyltransferase Methyltransf_11 PF08241.12 EDO07144.1 - 0.00018 22.1 0.0 0.00023 21.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDO07144.1 - 0.003 16.9 0.0 0.0075 15.6 0.0 1.6 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EDO07144.1 - 0.045 14.4 0.0 0.06 14.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain VESA1_N PF12785.7 EDO07145.1 - 8.4e-209 694.2 19.0 8.4e-209 694.2 19.0 2.2 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 ApoLp-III PF07464.11 EDO07145.1 - 0.041 14.0 1.3 1.8 8.7 0.2 2.4 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Baculo_PEP_C PF04513.12 EDO07145.1 - 0.17 11.9 0.3 1.4 8.9 0.0 2.6 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Apolipoprotein PF01442.18 EDO07145.1 - 0.66 9.8 2.0 1.4 8.7 2.0 1.5 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain VESA1_N PF12785.7 EDO07146.1 - 3.6e-183 609.7 25.3 1.3e-122 410.1 4.7 3.7 3 1 1 4 4 4 2 Variant erythrocyte surface antigen-1 Baculo_PEP_C PF04513.12 EDO07146.1 - 0.0037 17.3 0.1 0.44 10.6 0.0 3.0 1 1 1 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 EDO07146.1 - 0.0062 16.6 1.0 0.19 11.8 0.1 2.8 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) Apolipoprotein PF01442.18 EDO07146.1 - 0.016 15.1 0.7 0.034 14.0 0.7 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Spc7 PF08317.11 EDO07146.1 - 0.11 11.4 3.9 0.19 10.6 1.5 2.3 2 1 0 2 2 2 0 Spc7 kinetochore protein TPR_21 PF09976.9 EDO07146.1 - 0.18 11.5 2.4 0.23 11.1 1.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain HisKA_3 PF07730.13 EDO07146.1 - 0.25 11.9 0.3 7.3 7.2 0.0 2.9 2 0 0 2 2 2 0 Histidine kinase DUF3584 PF12128.8 EDO07146.1 - 0.38 8.2 2.1 0.53 7.7 0.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) DegS PF05384.11 EDO07146.1 - 0.44 10.0 2.7 0.55 9.7 0.1 2.3 3 0 0 3 3 3 0 Sensor protein DegS EzrA PF06160.12 EDO07146.1 - 0.68 8.0 2.0 10 4.1 0.4 2.1 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA TPR_MLP1_2 PF07926.12 EDO07146.1 - 1.7 8.7 5.3 1.9 8.6 3.3 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein F-box-like_2 PF13013.6 EDO07147.1 - 7.9e-15 54.7 0.9 1e-07 31.9 0.1 3.1 1 1 2 3 3 3 3 F-box-like domain Host_attach PF10116.9 EDO07147.1 - 0.055 14.0 0.1 19 5.8 0.0 3.3 3 1 0 3 3 3 0 Protein required for attachment to host cells Spc7 PF08317.11 EDO07148.1 - 0.00033 19.6 3.1 0.00038 19.4 3.1 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF1664 PF07889.12 EDO07148.1 - 0.0079 16.2 1.3 0.19 11.8 0.0 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) NPV_P10 PF05531.12 EDO07148.1 - 0.015 15.7 0.1 6 7.4 0.0 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Enolase_C PF00113.22 EDO07148.1 - 0.016 14.5 0.7 0.02 14.2 0.7 1.1 1 0 0 1 1 1 0 Enolase, C-terminal TIM barrel domain Sec8_exocyst PF04048.14 EDO07148.1 - 0.016 15.1 3.9 10 6.0 0.2 3.0 2 1 1 3 3 3 0 Sec8 exocyst complex component specific domain SesA PF17107.5 EDO07148.1 - 0.036 14.2 0.2 0.23 11.7 0.1 2.0 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases PIN_8 PF18476.1 EDO07148.1 - 0.041 13.8 0.2 0.046 13.6 0.2 1.0 1 0 0 1 1 1 0 PIN like domain Phage_holin_6_1 PF09682.10 EDO07148.1 - 0.043 14.2 4.4 0.088 13.2 4.4 1.6 1 1 0 1 1 1 0 Bacteriophage holin of superfamily 6 (Holin_LLH) DUF5633 PF18656.1 EDO07148.1 - 0.044 13.7 3.8 0.5 10.3 0.9 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5633) TMCO5 PF14992.6 EDO07148.1 - 0.061 12.9 1.7 0.087 12.4 1.7 1.1 1 0 0 1 1 1 0 TMCO5 family Rx_N PF18052.1 EDO07148.1 - 0.066 13.5 3.5 1.1 9.6 0.1 2.8 1 1 2 3 3 3 0 Rx N-terminal domain Ran-binding PF05508.11 EDO07148.1 - 0.067 12.2 0.1 0.078 12.0 0.1 1.1 1 0 0 1 1 1 0 RanGTP-binding protein LXG PF04740.12 EDO07148.1 - 0.07 12.8 0.2 0.12 12.0 0.2 1.5 1 1 0 1 1 1 0 LXG domain of WXG superfamily Baculo_PEP_C PF04513.12 EDO07148.1 - 0.072 13.1 0.0 0.25 11.4 0.0 1.9 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF5082 PF16888.5 EDO07148.1 - 0.095 13.0 1.5 0.9 9.8 0.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) YfdX PF10938.8 EDO07148.1 - 0.16 11.9 3.7 14 5.6 2.5 2.9 2 1 1 3 3 3 0 YfdX protein Fib_alpha PF08702.10 EDO07148.1 - 0.18 12.0 0.0 1.4 9.1 0.0 1.9 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.11 EDO07148.1 - 0.19 12.1 6.7 10 6.6 1.8 3.1 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF948 PF06103.11 EDO07148.1 - 0.23 11.7 1.3 0.71 10.2 0.8 2.0 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) TPR_MLP1_2 PF07926.12 EDO07148.1 - 0.37 10.9 3.6 6 6.9 1.3 2.7 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Seryl_tRNA_N PF02403.22 EDO07148.1 - 9.2 6.6 9.1 15 5.9 5.9 2.5 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain VESA1_N PF12785.7 EDO07149.1 - 7.7e-165 549.3 23.4 7.7e-165 549.3 23.4 2.0 2 0 0 2 2 2 1 Variant erythrocyte surface antigen-1 PEP-utilisers_N PF05524.13 EDO07149.1 - 0.12 12.5 1.2 3.9 7.7 0.0 2.4 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal Apolipoprotein PF01442.18 EDO07149.1 - 0.13 12.1 1.4 0.29 11.0 1.4 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.12 EDO07149.1 - 0.22 11.5 0.0 2.4 8.2 0.0 2.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Hrs_helical PF12210.8 EDO07149.1 - 0.25 11.9 1.0 0.88 10.1 0.2 2.1 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate DUF5082 PF16888.5 EDO07149.1 - 0.51 10.6 2.3 1.4 9.2 1.6 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) DUF4200 PF13863.6 EDO07149.1 - 0.73 10.2 2.1 28 5.1 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) DUF4407 PF14362.6 EDO07149.1 - 1.4 8.2 3.0 2.4 7.4 3.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 EDO07149.1 - 1.7 7.4 3.2 3.1 6.6 3.2 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein THOC7 PF05615.13 EDO07149.1 - 2.4 8.5 4.8 1.5 9.1 0.9 2.2 2 1 0 2 2 2 0 Tho complex subunit 7 F-box-like_2 PF13013.6 EDO07150.1 - 2.6e-06 27.4 0.3 8.6e-06 25.7 0.3 1.9 1 1 0 1 1 1 1 F-box-like domain DUF2076 PF09849.9 EDO07150.1 - 0.02 15.0 0.1 0.026 14.6 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) EIF4E-T PF10477.9 EDO07150.1 - 0.04 12.7 0.0 0.04 12.7 0.0 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E F-box-like_2 PF13013.6 EDO07151.1 - 1.3e-07 31.6 2.5 0.0013 18.6 0.1 2.5 2 1 0 2 2 2 2 F-box-like domain IL11 PF07400.11 EDO07151.1 - 0.022 14.4 0.0 0.039 13.6 0.0 1.3 1 0 0 1 1 1 0 Interleukin 11 VESA1_N PF12785.7 EDO07152.1 - 5.3e-21 75.1 13.3 2.1e-12 46.8 10.3 4.9 4 1 1 5 5 5 3 Variant erythrocyte surface antigen-1 Med3 PF11593.8 EDO07152.1 - 6.5 5.8 5.6 5.5 6.1 1.0 2.2 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal VESA1_N PF12785.7 EDO07153.1 - 2.9e-223 741.9 18.4 2.9e-223 741.9 18.4 2.6 3 0 0 3 3 2 1 Variant erythrocyte surface antigen-1 DUF885 PF05960.11 EDO07153.1 - 0.019 14.6 0.1 0.035 13.8 0.1 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) DUF2524 PF10732.9 EDO07153.1 - 0.021 15.1 2.3 0.2 12.0 0.0 2.8 2 1 0 3 3 3 0 Protein of unknown function (DUF2524) Rx_N PF18052.1 EDO07153.1 - 0.12 12.6 5.8 8.6 6.7 0.0 3.4 3 0 0 3 3 3 0 Rx N-terminal domain DUF1664 PF07889.12 EDO07153.1 - 0.14 12.2 1.5 6.5 6.8 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) ApoLp-III PF07464.11 EDO07153.1 - 0.17 11.9 4.9 3 7.9 0.3 2.7 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) HisKA_3 PF07730.13 EDO07153.1 - 0.2 12.2 0.8 44 4.7 0.0 3.1 3 0 0 3 3 2 0 Histidine kinase 7TMR-HDED PF07697.11 EDO07153.1 - 0.26 11.4 1.5 0.48 10.5 1.5 1.3 1 0 0 1 1 1 0 7TM-HD extracellular Apolipoprotein PF01442.18 EDO07153.1 - 0.36 10.7 5.3 0.97 9.3 5.3 1.7 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.12 EDO07153.1 - 0.43 10.6 3.1 31 4.6 0.1 3.4 2 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus PEP-utilisers_N PF05524.13 EDO07153.1 - 0.71 10.1 4.6 11 6.3 0.1 2.6 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal CdvA PF18822.1 EDO07153.1 - 0.75 9.6 5.4 0.42 10.5 0.2 2.8 2 0 0 2 2 2 0 CdvA-like coiled-coil domain AAA_23 PF13476.6 EDO07153.1 - 1.1 9.7 7.6 0.51 10.8 1.5 2.5 2 0 0 2 2 2 0 AAA domain RRF PF01765.19 EDO07153.1 - 1.2 9.1 7.5 0.15 12.0 1.0 2.4 2 0 0 2 2 2 0 Ribosome recycling factor THOC7 PF05615.13 EDO07153.1 - 1.6 9.1 10.9 0.056 13.7 0.7 2.7 2 1 1 3 3 3 0 Tho complex subunit 7 Remorin_C PF03763.13 EDO07153.1 - 1.8 8.5 7.6 0.52 10.2 2.1 2.4 2 0 0 2 2 2 0 Remorin, C-terminal region DUF4164 PF13747.6 EDO07153.1 - 2.6 8.4 7.4 12 6.3 3.9 3.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4164) TBCA PF02970.16 EDO07153.1 - 3.1 8.2 9.4 0.25 11.7 0.6 3.0 2 1 1 3 3 3 0 Tubulin binding cofactor A ChW PF07538.11 EDO07153.1 - 3.1 7.8 10.3 0.091 12.7 1.4 2.6 2 0 0 2 2 2 0 Clostridial hydrophobic W DUF883 PF05957.13 EDO07153.1 - 4.9 7.8 9.1 3.3 8.4 0.1 2.9 3 0 0 3 3 2 0 Bacterial protein of unknown function (DUF883) Jnk-SapK_ap_N PF09744.9 EDO07153.1 - 5.1 7.3 6.1 1.3 9.2 1.0 2.5 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 FliJ PF02050.16 EDO07153.1 - 5.2 7.3 6.8 18 5.6 0.5 3.2 2 1 1 3 3 3 0 Flagellar FliJ protein TSP_1 PF00090.19 EDO07154.1 - 0.0051 17.0 3.4 0.0051 17.0 3.4 2.4 3 0 0 3 3 3 1 Thrombospondin type 1 domain WD40 PF00400.32 EDO07155.1 - 1.2e-07 32.3 11.0 0.0036 18.1 0.4 6.6 5 2 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO07155.1 - 2e-07 31.2 0.0 0.33 11.3 0.0 4.1 4 0 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain DUF1433 PF07252.11 EDO07155.1 - 0.06 13.6 0.0 0.36 11.1 0.1 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1433) DUF763 PF05559.11 EDO07155.1 - 0.16 11.1 0.0 0.25 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF763) Tfb2 PF03849.14 EDO07156.1 - 1.5e-50 172.2 5.1 6.5e-48 163.5 5.1 2.5 1 1 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 EDO07156.1 - 0.0013 19.2 0.9 0.0043 17.5 0.9 2.0 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 EDO07156.1 - 0.031 14.4 0.0 0.067 13.3 0.0 1.6 1 0 0 1 1 1 0 Helicase conserved C-terminal domain PH PF00169.29 EDO07157.1 - 0.0011 19.5 0.3 0.0018 18.7 0.3 1.4 1 0 0 1 1 1 1 PH domain PH_10 PF15411.6 EDO07157.1 - 0.18 12.0 1.7 0.41 10.9 1.7 1.7 1 1 0 1 1 1 0 Pleckstrin homology domain Synaptobrevin PF00957.21 EDO07158.1 - 1.1e-06 28.3 1.5 2.5e-06 27.2 1.5 1.6 1 0 0 1 1 1 1 Synaptobrevin I_LWEQ PF01608.17 EDO07158.1 - 0.0014 18.9 0.1 0.004 17.4 0.1 1.7 2 0 0 2 2 2 1 I/LWEQ domain T3SSipB PF16535.5 EDO07158.1 - 0.048 14.1 0.9 0.078 13.5 0.9 1.3 1 0 0 1 1 1 0 Type III cell invasion protein SipB LSM PF01423.22 EDO07159.1 - 5.9e-14 51.5 0.1 7.5e-14 51.2 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EDO07159.1 - 0.0013 18.8 0.0 0.0014 18.7 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain Hfq PF17209.3 EDO07159.1 - 0.062 12.9 0.0 0.084 12.5 0.0 1.2 1 0 0 1 1 1 0 Hfq protein Pribosyltran_N PF13793.6 EDO07160.1 - 1.1e-38 131.7 0.0 1.4e-37 128.2 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EDO07160.1 - 6e-17 62.3 0.6 1.2e-16 61.3 0.6 1.4 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EDO07160.1 - 6.7e-11 42.0 0.2 1.2e-10 41.1 0.2 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EDO07160.1 - 0.0002 20.8 0.0 0.00036 20.0 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PGK PF00162.19 EDO07161.1 - 1.4e-139 465.3 0.2 1.5e-139 465.1 0.2 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase Fer4_18 PF13746.6 EDO07162.1 - 0.11 12.7 1.8 0.19 11.9 0.1 2.3 3 0 0 3 3 3 0 4Fe-4S dicluster domain Ribosomal_L29 PF00831.23 EDO07163.1 - 1e-17 63.8 1.0 1e-17 63.8 1.0 1.9 2 1 0 2 2 2 1 Ribosomal L29 protein Ribosomal_S9 PF00380.19 EDO07163.1 - 0.0025 18.4 1.1 0.0031 18.0 1.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S9/S16 EzrA PF06160.12 EDO07163.1 - 0.003 15.8 2.3 0.0035 15.6 2.3 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA DUF22 PF01629.16 EDO07163.1 - 0.045 13.4 0.2 0.068 12.9 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF22 Z1 PF10593.9 EDO07163.1 - 0.055 13.0 2.1 0.11 12.0 0.3 1.9 1 1 1 2 2 2 0 Z1 domain ADK PF00406.22 EDO07164.1 - 3.6e-30 105.1 0.0 4.9e-30 104.6 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EDO07164.1 - 1.8e-14 54.3 0.0 3.7e-14 53.3 0.0 1.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EDO07164.1 - 1.3e-07 32.2 0.0 2.5e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 EDO07164.1 - 0.0015 18.5 1.3 0.0033 17.4 1.3 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.6 EDO07164.1 - 0.0047 17.1 0.0 0.0076 16.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EDO07164.1 - 0.022 15.2 0.0 0.043 14.2 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EDO07164.1 - 0.042 13.6 0.0 0.075 12.8 0.0 1.4 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Cytidylate_kin PF02224.18 EDO07164.1 - 0.064 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase RRM_1 PF00076.22 EDO07165.1 - 1e-11 44.5 0.0 1.4e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EAP30 PF04157.16 EDO07166.1 - 2.2e-05 23.8 0.9 2.8e-05 23.5 0.9 1.3 1 1 0 1 1 1 1 EAP30/Vps36 family HHH_2 PF12826.7 EDO07166.1 - 0.12 12.5 0.1 0.31 11.2 0.1 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif ABC_tran PF00005.27 EDO07168.1 - 1.5e-37 129.2 3.6 6.2e-19 68.9 0.0 4.5 5 0 0 5 5 4 3 ABC transporter AAA_21 PF13304.6 EDO07168.1 - 2.4e-21 76.8 14.5 8.5e-09 35.6 0.3 4.7 5 0 0 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDO07168.1 - 3.2e-13 49.6 6.7 1.1e-07 31.6 0.7 3.9 4 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDO07168.1 - 1.4e-09 37.6 0.2 0.0025 17.5 0.1 3.2 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EDO07168.1 - 4.6e-06 27.1 0.0 0.15 12.5 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_15 PF13175.6 EDO07168.1 - 1.2e-05 25.2 16.0 0.25 11.0 0.0 5.0 4 1 0 5 5 5 3 AAA ATPase domain AAA_23 PF13476.6 EDO07168.1 - 1.3e-05 25.8 11.3 0.11 13.0 6.8 3.4 2 1 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EDO07168.1 - 6.2e-05 23.0 0.3 0.071 13.0 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EDO07168.1 - 7.4e-05 23.0 0.6 1.4 9.2 0.0 4.3 4 0 0 4 4 4 1 AAA domain MMR_HSR1 PF01926.23 EDO07168.1 - 0.00045 20.3 0.1 0.47 10.5 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_7 PF12775.7 EDO07168.1 - 0.00075 19.1 0.0 0.24 10.9 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region Roc PF08477.13 EDO07168.1 - 0.0027 17.9 0.0 3.9 7.7 0.0 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 EDO07168.1 - 0.0033 18.0 0.6 1.8 9.1 0.0 3.5 4 0 0 4 4 3 1 AAA domain AAA_5 PF07728.14 EDO07168.1 - 0.0036 17.3 0.1 5.3 7.0 0.0 3.3 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EDO07168.1 - 0.0064 16.2 0.0 4.7 6.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain ATP-synt_ab PF00006.25 EDO07168.1 - 0.0081 15.8 0.0 4.7 6.8 0.0 2.2 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain AAA_28 PF13521.6 EDO07168.1 - 0.015 15.6 0.2 5.2 7.3 0.0 3.0 3 0 0 3 3 3 0 AAA domain MeaB PF03308.16 EDO07168.1 - 0.015 14.3 0.1 2.4 7.0 0.0 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 EDO07168.1 - 0.017 15.0 0.0 4.7 7.1 0.0 2.6 2 0 0 2 2 2 0 NACHT domain HTH_WhiA PF02650.14 EDO07168.1 - 0.019 15.3 0.0 1.1 9.6 0.0 2.9 2 0 0 2 2 2 0 WhiA C-terminal HTH domain IstB_IS21 PF01695.17 EDO07168.1 - 0.023 14.4 0.0 10 5.8 0.0 3.2 3 0 0 3 3 3 0 IstB-like ATP binding protein Sigma54_activat PF00158.26 EDO07168.1 - 0.046 13.4 0.2 6 6.5 0.0 3.4 4 0 0 4 4 3 0 Sigma-54 interaction domain DUF815 PF05673.13 EDO07168.1 - 0.054 12.6 3.9 0.084 12.0 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF815) MobB PF03205.14 EDO07168.1 - 0.06 13.3 0.0 2.1 8.2 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B TsaE PF02367.17 EDO07168.1 - 0.069 13.2 0.0 7.7 6.5 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 EDO07168.1 - 0.073 13.5 0.0 17 5.8 0.0 2.9 2 0 0 2 2 2 0 RNA helicase AAA PF00004.29 EDO07168.1 - 0.079 13.4 0.1 34 4.9 0.0 3.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EDO07168.1 - 0.079 12.7 0.0 7.6 6.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EDO07168.1 - 0.095 12.1 0.1 0.72 9.2 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI SRP54 PF00448.22 EDO07168.1 - 0.13 11.9 0.0 6.7 6.3 0.0 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_25 PF13481.6 EDO07168.1 - 0.18 11.3 0.0 8.2 6.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain Neocarzinostat PF00960.18 EDO07169.1 - 0.041 13.9 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 Neocarzinostatin family EGF_3 PF12947.7 EDO07169.1 - 0.28 11.4 19.5 0.067 13.4 6.6 3.5 2 1 1 3 3 3 0 EGF domain PLU-1 PF08429.11 EDO07170.1 - 7.9e-54 183.1 1.0 1.7e-53 182.0 0.2 1.8 2 0 0 2 2 2 1 PLU-1-like protein Dynactin_p22 PF07426.11 EDO07170.1 - 0.1 12.5 2.2 0.39 10.6 2.2 2.1 1 0 0 1 1 1 0 Dynactin subunit p22 ThiF PF00899.21 EDO07171.1 - 1.8e-21 76.6 0.0 2.9e-21 75.9 0.0 1.2 1 0 0 1 1 1 1 ThiF family 2-Hacid_dh_C PF02826.19 EDO07171.1 - 0.23 10.8 0.0 1 8.7 0.0 1.9 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain tRNA-synt_2b PF00587.25 EDO07172.1 - 2.6e-30 105.7 0.0 7.2e-30 104.3 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EDO07172.1 - 1.5e-19 69.9 0.7 3.3e-19 68.8 0.1 1.9 2 0 0 2 2 2 1 Anticodon binding domain tRNA_SAD PF07973.14 EDO07172.1 - 8.3e-06 25.8 0.0 1.8e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Transket_pyr PF02779.24 EDO07173.1 - 2.8e-41 141.1 0.0 4e-41 140.7 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EDO07173.1 - 5.9e-35 119.8 0.0 9.3e-35 119.2 0.0 1.3 1 0 0 1 1 1 1 Transketolase, C-terminal domain DUF3530 PF12048.8 EDO07174.1 - 0.0057 16.1 0.2 0.007 15.8 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3530) MMS19_N PF14500.6 EDO07175.1 - 6.1e-33 114.5 0.6 1.4e-32 113.3 0.6 1.6 1 0 0 1 1 1 1 Dos2-interacting transcription regulator of RNA-Pol-II PhyH PF05721.13 EDO07175.1 - 1.7e-08 35.0 0.0 4e-08 33.8 0.0 1.6 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Tim17 PF02466.19 EDO07176.1 - 2e-27 95.8 8.5 2.6e-27 95.4 8.5 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Tim44 PF04280.15 EDO07177.1 - 2e-35 122.0 0.1 8.7e-35 120.0 0.0 2.0 3 0 0 3 3 3 1 Tim44-like domain CDC73_N PF16050.5 EDO07177.1 - 0.3 10.4 4.7 0.45 9.8 4.7 1.2 1 0 0 1 1 1 0 Paf1 complex subunit CDC73 N-terminal LSM PF01423.22 EDO07178.1 - 2.6e-16 59.1 1.3 3.5e-16 58.6 1.3 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EDO07178.1 - 0.0088 16.2 0.2 0.011 15.8 0.2 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain BPL_C PF02237.17 EDO07178.1 - 0.082 12.8 0.3 0.16 11.9 0.3 1.4 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain GrpE PF01025.19 EDO07180.1 - 1e-42 145.6 6.3 1.5e-42 145.1 6.3 1.3 1 1 0 1 1 1 1 GrpE V_ATPase_I PF01496.19 EDO07180.1 - 0.025 12.5 3.2 0.032 12.2 3.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family COG5 PF10392.9 EDO07180.1 - 0.043 14.0 0.6 0.086 13.0 0.6 1.5 1 0 0 1 1 1 0 Golgi transport complex subunit 5 CLZ PF16526.5 EDO07180.1 - 0.11 12.9 3.3 0.27 11.6 3.3 1.7 1 1 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels CVNH PF08881.10 EDO07180.1 - 0.12 13.1 0.0 0.27 12.0 0.0 1.6 1 0 0 1 1 1 0 CVNH domain BNIP2 PF12496.8 EDO07180.1 - 5.1 7.5 7.5 8.6 6.8 5.0 2.0 1 1 1 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 RRS1 PF04939.12 EDO07181.1 - 4.4e-49 166.5 2.0 4.8e-49 166.3 0.0 1.8 2 0 0 2 2 2 1 Ribosome biogenesis regulatory protein (RRS1) RRM_1 PF00076.22 EDO07182.1 - 3.2e-78 257.5 1.1 5.8e-20 70.9 0.1 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 EDO07182.1 - 5.5e-28 97.0 0.2 4.6e-26 90.8 1.0 2.9 4 0 0 4 4 4 1 Poly-adenylate binding protein, unique domain RRM_3 PF08777.11 EDO07182.1 - 4.1e-05 23.6 0.2 3.8 7.6 0.0 4.0 4 0 0 4 4 4 2 RNA binding motif RNA_bind PF08675.11 EDO07182.1 - 0.00049 20.1 0.7 0.011 15.7 0.0 3.3 4 1 1 5 5 5 1 RNA binding domain RRM_7 PF16367.5 EDO07182.1 - 0.00056 20.0 0.0 8.1 6.6 0.0 4.8 4 1 0 4 4 4 1 RNA recognition motif Nup35_RRM_2 PF14605.6 EDO07182.1 - 0.0028 17.6 0.2 30 4.7 0.0 4.2 4 0 0 4 4 4 0 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.13 EDO07182.1 - 0.0052 16.7 0.1 0.44 10.5 0.0 3.2 2 1 1 3 3 3 1 Nup53/35/40-type RNA recognition motif Pkinase PF00069.25 EDO07184.1 - 1.5e-35 122.9 0.1 2.1e-29 102.7 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO07184.1 - 2.6e-22 79.4 0.0 1.8e-17 63.5 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Choline_kinase PF01633.20 EDO07185.1 - 1.2e-39 136.1 0.2 1.8e-39 135.6 0.2 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EDO07185.1 - 5.7e-12 46.1 0.0 9.5e-12 45.3 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 EDO07185.1 - 0.00023 20.5 0.1 0.00039 19.7 0.1 1.5 1 1 0 1 1 1 1 Fructosamine kinase EcKinase PF02958.20 EDO07185.1 - 0.0027 17.0 0.1 0.0056 16.0 0.1 1.6 1 0 0 1 1 1 1 Ecdysteroid kinase RIO1 PF01163.22 EDO07185.1 - 0.0028 17.3 0.2 0.022 14.3 0.1 2.2 2 0 0 2 2 2 1 RIO1 family SapB_1 PF05184.15 EDO07185.1 - 0.2 11.7 0.5 8.6 6.5 0.0 2.9 3 0 0 3 3 3 0 Saposin-like type B, region 1 Choline_kinase PF01633.20 EDO07186.1 - 4.7e-42 144.0 0.2 6.9e-42 143.4 0.2 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EDO07186.1 - 5.2e-09 36.4 0.0 9.1e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EDO07186.1 - 0.0016 17.8 0.2 0.0035 16.7 0.2 1.6 1 1 0 1 1 1 1 Ecdysteroid kinase Fructosamin_kin PF03881.14 EDO07186.1 - 0.0085 15.3 0.0 0.013 14.7 0.0 1.3 1 0 0 1 1 1 1 Fructosamine kinase Bromodomain PF00439.25 EDO07187.1 - 0.036 14.2 0.3 1.3 9.2 0.0 2.9 3 0 0 3 3 3 0 Bromodomain BET PF17035.5 EDO07187.1 - 0.19 11.9 0.2 0.19 11.9 0.2 2.7 2 1 0 2 2 2 0 Bromodomain extra-terminal - transcription regulation Tsc35 PF15079.6 EDO07187.1 - 0.24 11.0 1.2 0.4 10.2 1.2 1.3 1 0 0 1 1 1 0 Testis-specific protein 35 LSM PF01423.22 EDO07188.1 - 4.9e-11 42.2 0.0 8.2e-11 41.4 0.0 1.4 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EDO07188.1 - 0.013 15.7 0.0 0.026 14.6 0.0 1.6 1 1 0 1 1 1 0 Ataxin 2 SM domain AAA PF00004.29 EDO07190.1 - 5.7e-95 314.8 0.0 5.5e-46 156.3 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO07190.1 - 2.1e-23 81.8 1.1 4.7e-11 42.3 0.8 2.8 2 1 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 EDO07190.1 - 9.4e-22 77.0 0.2 2.6e-21 75.6 0.2 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_16 PF13191.6 EDO07190.1 - 1.9e-13 51.2 0.2 8.4e-05 23.0 0.0 4.2 2 2 1 3 3 3 2 AAA ATPase domain RuvB_N PF05496.12 EDO07190.1 - 6.8e-13 48.7 0.0 2.4e-05 24.1 0.0 3.0 3 0 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EDO07190.1 - 6.3e-12 45.9 0.0 3.2e-06 27.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EDO07190.1 - 2.2e-11 44.1 0.0 2.5e-05 24.5 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_5 PF07728.14 EDO07190.1 - 1e-10 41.7 0.1 8.3e-06 25.9 0.0 3.2 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EDO07190.1 - 1.3e-08 34.4 0.0 0.00061 19.1 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 EDO07190.1 - 1.4e-08 35.1 0.2 0.052 13.8 0.0 3.8 2 2 2 4 4 4 2 AAA domain CDC48_2 PF02933.17 EDO07190.1 - 8.5e-08 31.9 0.0 2.1e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_18 PF13238.6 EDO07190.1 - 1.9e-07 31.7 0.0 0.032 14.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 EDO07190.1 - 3.7e-07 30.2 0.0 0.012 15.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 EDO07190.1 - 8.1e-07 29.4 0.0 0.019 15.4 0.0 2.9 2 0 0 2 2 2 2 RNA helicase Mg_chelatase PF01078.21 EDO07190.1 - 8.2e-07 28.6 0.2 0.036 13.5 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 EDO07190.1 - 1.9e-06 27.6 0.4 0.81 9.2 0.0 3.5 2 1 1 3 3 3 2 AAA domain Vps4_C PF09336.10 EDO07190.1 - 6.1e-06 26.1 0.2 0.00097 19.1 0.1 2.6 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain ATPase_2 PF01637.18 EDO07190.1 - 8.2e-06 25.9 0.0 0.91 9.4 0.0 3.5 3 1 1 4 4 3 2 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 EDO07190.1 - 1.1e-05 25.2 0.0 0.17 11.6 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_28 PF13521.6 EDO07190.1 - 5.3e-05 23.5 0.0 0.52 10.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.27 EDO07190.1 - 6.8e-05 23.4 0.0 0.27 11.7 0.0 3.0 2 1 0 2 2 2 2 ABC transporter AAA_17 PF13207.6 EDO07190.1 - 7.5e-05 23.2 0.0 0.27 11.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 EDO07190.1 - 7.7e-05 22.3 0.0 0.35 10.4 0.0 2.6 2 1 0 2 2 2 2 P-loop containing dynein motor region ATPase PF06745.13 EDO07190.1 - 9.2e-05 21.9 0.1 2.4 7.4 0.0 3.3 3 0 0 3 3 3 1 KaiC Viral_helicase1 PF01443.18 EDO07190.1 - 0.00011 22.0 0.0 0.012 15.4 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase NACHT PF05729.12 EDO07190.1 - 0.00014 21.8 0.0 0.58 10.1 0.0 3.0 2 1 1 3 3 3 2 NACHT domain AAA_24 PF13479.6 EDO07190.1 - 0.00017 21.4 0.3 0.33 10.6 0.0 3.2 3 1 0 3 3 2 1 AAA domain Zeta_toxin PF06414.12 EDO07190.1 - 0.00017 20.9 0.0 0.56 9.4 0.0 3.3 4 0 0 4 4 3 1 Zeta toxin TsaE PF02367.17 EDO07190.1 - 0.00019 21.4 0.0 0.97 9.4 0.0 2.6 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 EDO07190.1 - 0.00025 20.2 0.0 0.54 9.3 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 NB-ARC PF00931.22 EDO07190.1 - 0.0006 19.1 0.0 0.89 8.7 0.0 2.3 2 0 0 2 2 2 2 NB-ARC domain Sigma54_activat PF00158.26 EDO07190.1 - 0.00063 19.5 0.0 1 9.1 0.0 3.1 2 1 0 2 2 2 1 Sigma-54 interaction domain UFD1 PF03152.14 EDO07190.1 - 0.00082 18.9 0.0 0.0015 18.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 Bac_DnaA PF00308.18 EDO07190.1 - 0.0013 18.7 0.0 0.53 10.1 0.0 2.3 2 0 0 2 2 2 1 Bacterial dnaA protein DUF815 PF05673.13 EDO07190.1 - 0.0016 17.6 0.0 0.59 9.2 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) PhoH PF02562.16 EDO07190.1 - 0.0019 17.7 0.1 1.9 7.9 0.0 2.7 2 0 0 2 2 2 1 PhoH-like protein AAA_3 PF07726.11 EDO07190.1 - 0.0024 17.7 0.0 3.1 7.7 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.6 EDO07190.1 - 0.0042 17.2 0.0 0.91 9.6 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain DUF2075 PF09848.9 EDO07190.1 - 0.0062 15.8 0.0 0.66 9.1 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Rad17 PF03215.15 EDO07190.1 - 0.0078 16.2 0.0 1.2 9.0 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_19 PF13245.6 EDO07190.1 - 0.01 16.2 0.1 5.1 7.4 0.1 3.1 2 1 1 3 3 2 0 AAA domain AAA_30 PF13604.6 EDO07190.1 - 0.028 14.1 0.0 6.6 6.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain Cytidylate_kin2 PF13189.6 EDO07190.1 - 0.029 14.5 0.0 9.7 6.3 0.0 2.9 3 0 0 3 3 2 0 Cytidylate kinase-like family AAA_11 PF13086.6 EDO07190.1 - 0.031 14.1 0.0 9.5 5.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain Molydop_binding PF01568.21 EDO07190.1 - 0.031 14.3 0.0 0.083 12.9 0.0 1.6 1 0 0 1 1 1 0 Molydopterin dinucleotide binding domain NTPase_1 PF03266.15 EDO07190.1 - 0.038 13.9 0.5 13 5.7 0.0 3.6 4 1 0 4 4 3 0 NTPase SKI PF01202.22 EDO07190.1 - 0.041 14.0 0.1 11 6.1 0.0 2.4 2 0 0 2 2 2 0 Shikimate kinase Cytidylate_kin PF02224.18 EDO07190.1 - 0.041 13.6 0.1 5.2 6.7 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase AAA_29 PF13555.6 EDO07190.1 - 0.05 13.4 0.0 5.8 6.7 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain Zot PF05707.12 EDO07190.1 - 0.21 11.2 0.1 4.4 6.9 0.0 2.9 2 2 0 2 2 2 0 Zonular occludens toxin (Zot) SRR1 PF07985.12 EDO07191.1 - 8.8e-11 41.7 0.2 1.8e-10 40.7 0.2 1.6 1 0 0 1 1 1 1 SRR1 SNF2_N PF00176.23 EDO07192.1 - 7.8e-67 225.5 0.0 1.5e-66 224.5 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 EDO07192.1 - 1.3e-27 96.1 0.1 4.1e-27 94.5 0.1 2.0 1 0 0 1 1 1 1 SLIDE Helicase_C PF00271.31 EDO07192.1 - 6.3e-20 71.6 0.2 2.5e-19 69.7 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO07192.1 - 8.6e-14 51.9 0.2 3.8e-13 49.8 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDO07192.1 - 2e-06 27.7 0.0 6.2e-06 26.1 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 EDO07192.1 - 5.5e-06 25.8 0.0 1.3e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Myb_DNA-binding PF00249.31 EDO07192.1 - 5e-05 23.4 0.1 0.00031 20.9 0.0 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain SWI2_SNF2 PF18766.1 EDO07192.1 - 0.00011 22.0 0.0 0.0016 18.2 0.0 2.3 2 0 0 2 2 2 1 SWI2/SNF2 ATPase Vps54_N PF10475.9 EDO07192.1 - 0.012 14.9 0.3 0.027 13.8 0.3 1.5 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex AAA_14 PF13173.6 EDO07192.1 - 0.013 15.6 0.1 0.046 13.7 0.1 2.0 1 0 0 1 1 1 0 AAA domain Glutaredoxin PF00462.24 EDO07192.1 - 0.11 12.7 0.1 0.34 11.2 0.1 1.8 1 0 0 1 1 1 0 Glutaredoxin AAA_11 PF13086.6 EDO07192.1 - 5.2 6.8 6.1 2.9 7.6 0.0 2.8 2 1 0 2 2 2 0 AAA domain Fumble PF03630.14 EDO07193.1 - 3.4e-21 75.8 0.0 1.1e-20 74.1 0.0 1.7 2 0 0 2 2 2 1 Fumble HSP90 PF00183.18 EDO07194.1 - 2.4e-140 468.9 27.4 9.3e-137 457.0 12.8 2.5 2 1 1 3 3 3 2 Hsp90 protein HATPase_c_3 PF13589.6 EDO07194.1 - 3.6e-12 46.3 0.2 1.1e-11 44.6 0.2 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EDO07194.1 - 4.2e-08 33.7 0.1 1.2e-07 32.2 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF4413 PF14372.6 EDO07194.1 - 0.11 12.9 1.5 0.43 11.0 1.5 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) YyzF PF14116.6 EDO07194.1 - 0.63 10.1 6.1 0.12 12.4 1.7 2.1 2 0 0 2 2 2 0 YyzF-like protein TRAPPC-Trs85 PF12739.7 EDO07195.1 - 1.1e-11 44.4 0.2 1.8e-11 43.7 0.2 1.3 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Elong-fact-P_C PF09285.11 EDO07197.1 - 3.4e-09 36.3 0.1 8.3e-09 35.1 0.1 1.7 1 0 0 1 1 1 1 Elongation factor P, C-terminal EFP_N PF08207.12 EDO07197.1 - 3.9e-08 33.2 0.1 8e-08 32.2 0.1 1.6 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain EFP PF01132.20 EDO07197.1 - 0.0051 16.8 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor P (EF-P) OB domain Myb_DNA-binding PF00249.31 EDO07200.1 - 0.024 14.8 0.0 0.064 13.5 0.0 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain OSCP PF00213.18 EDO07201.1 - 7.2e-42 143.4 0.0 8.3e-42 143.2 0.0 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit p25-alpha PF05517.12 EDO07202.1 - 4e-22 79.0 0.0 5.1e-22 78.7 0.0 1.0 1 0 0 1 1 1 1 p25-alpha Prefoldin PF02996.17 EDO07203.1 - 4.2e-22 78.3 0.1 5.4e-22 77.9 0.1 1.1 1 0 0 1 1 1 1 Prefoldin subunit Baculo_PEP_C PF04513.12 EDO07203.1 - 0.007 16.4 0.2 1.3 9.0 0.1 2.1 2 0 0 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus Tsi6 PF18660.1 EDO07203.1 - 0.038 14.0 0.1 0.1 12.6 0.1 1.7 2 0 0 2 2 2 0 Tsi6 BLOC1_2 PF10046.9 EDO07203.1 - 0.045 14.0 0.7 11 6.4 0.1 2.7 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.12 EDO07203.1 - 0.059 13.8 0.1 12 6.4 0.0 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.10 EDO07203.1 - 0.085 13.0 0.9 11 6.2 0.1 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Syntaxin-6_N PF09177.11 EDO07203.1 - 0.21 12.1 1.3 7.9 7.1 0.1 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal RRM_1 PF00076.22 EDO07204.1 - 2.5e-20 72.0 0.0 3.6e-20 71.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDO07204.1 - 0.0078 15.8 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Plk4_PB1 PF18190.1 EDO07204.1 - 0.055 13.6 0.0 0.094 12.9 0.0 1.3 1 0 0 1 1 1 0 Polo-like Kinase 4 Polo Box 1 Cofilin_ADF PF00241.20 EDO07205.1 - 1.4e-16 60.4 0.0 1.8e-16 60.0 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein PaO PF08417.12 EDO07205.1 - 0.052 13.7 0.0 0.066 13.4 0.0 1.2 1 0 0 1 1 1 0 Pheophorbide a oxygenase HEAT PF02985.22 EDO07206.1 - 1.9e-07 30.7 0.3 0.25 11.7 0.0 4.9 5 0 0 5 5 5 2 HEAT repeat Vac14_Fab1_bd PF12755.7 EDO07206.1 - 0.00077 20.0 0.1 9.9 6.8 0.1 3.6 3 0 0 3 3 3 2 Vacuolar 14 Fab1-binding region Pkinase PF00069.25 EDO07206.1 - 0.0014 18.1 0.7 0.0033 16.8 0.1 2.0 2 0 0 2 2 2 1 Protein kinase domain Cnd1 PF12717.7 EDO07206.1 - 0.021 14.9 1.2 0.49 10.4 0.2 3.1 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 DUF930 PF06059.12 EDO07206.1 - 0.055 14.0 0.0 0.15 12.6 0.0 1.7 1 0 0 1 1 1 0 Domain of Unknown Function (DUF930) Ribosomal_L31e PF01198.19 EDO07207.1 - 1.2e-39 134.4 2.9 1.5e-39 134.1 2.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L31e Helicase_C PF00271.31 EDO07208.1 - 1.6e-20 73.5 1.5 2.1e-20 73.1 0.4 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDO07208.1 - 1.1e-06 28.5 0.4 9.2e-06 25.5 0.1 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase E1-E2_ATPase PF00122.20 EDO07209.1 - 1.1e-18 67.4 1.3 2.5e-18 66.2 0.4 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EDO07209.1 - 1.8e-09 38.2 0.0 3.4e-05 24.2 0.1 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDO07209.1 - 0.0079 16.3 0.0 0.025 14.7 0.0 1.8 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EDO07209.1 - 0.016 14.9 0.0 0.044 13.5 0.0 1.7 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus Imm30 PF15565.6 EDO07211.1 - 0.12 12.4 0.1 16 5.6 0.0 2.9 2 0 0 2 2 2 0 Immunity protein 30 ANAPC4_WD40 PF12894.7 EDO07212.1 - 0.0003 21.0 0.0 0.0056 17.0 0.0 2.9 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO07212.1 - 0.46 11.5 5.0 0.76 10.7 0.0 3.7 4 0 0 4 4 4 0 WD domain, G-beta repeat Rpr2 PF04032.16 EDO07214.1 - 2.2e-21 75.9 0.2 3.1e-21 75.4 0.2 1.2 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain Med26_M PF15694.5 EDO07215.1 - 0.25 11.4 0.0 0.35 10.9 0.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit 26 middle domain FAM176 PF14851.6 EDO07216.1 - 0.037 13.7 0.4 0.089 12.4 0.4 1.6 1 0 0 1 1 1 0 FAM176 family AIG1 PF04548.16 EDO07216.1 - 0.1 11.9 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 AIG1 family Spo12 PF05032.12 EDO07216.1 - 0.12 12.3 0.1 0.42 10.6 0.1 1.9 1 1 0 1 1 1 0 Spo12 family TRAP_alpha PF03896.16 EDO07216.1 - 0.13 11.4 0.6 0.22 10.7 0.6 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit BRCA-2_OB1 PF09103.10 EDO07218.1 - 0.023 14.6 0.0 0.38 10.7 0.0 2.5 1 1 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 zf-C2H2_aberr PF17017.5 EDO07219.1 - 0.0054 16.9 0.6 0.012 15.8 0.6 1.6 1 0 0 1 1 1 1 Aberrant zinc-finger zf-RING_5 PF14634.6 EDO07219.1 - 0.011 15.7 11.8 0.011 15.7 11.8 1.9 2 0 0 2 2 2 0 zinc-RING finger domain Prok-RING_4 PF14447.6 EDO07219.1 - 0.031 14.1 11.0 0.038 13.9 10.0 1.7 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EDO07219.1 - 0.68 9.8 11.4 1.9 8.4 11.4 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Vfa1 PF08432.10 EDO07219.1 - 10 6.4 8.1 24 5.2 8.1 1.6 1 1 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Proteasome PF00227.26 EDO07220.1 - 1.7e-46 158.1 0.0 2.1e-46 157.8 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Cyclin_N PF00134.23 EDO07222.1 - 0.017 14.8 0.3 0.086 12.6 0.1 2.2 2 1 0 2 2 2 0 Cyclin, N-terminal domain Syja_N PF02383.18 EDO07223.1 - 2.7e-63 214.2 0.1 4e-63 213.6 0.1 1.2 1 0 0 1 1 1 1 SacI homology domain Ashwin PF15323.6 EDO07226.1 - 0.11 12.6 0.2 0.18 11.8 0.2 1.3 1 0 0 1 1 1 0 Developmental protein CwfJ_C_1 PF04677.15 EDO07227.1 - 5.7e-22 77.9 0.3 9.9e-22 77.1 0.3 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 RRM_1 PF00076.22 EDO07227.1 - 5e-10 39.1 0.0 1.2e-09 37.8 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EDO07227.1 - 0.1 12.7 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif zf-RING_7 PF02591.15 EDO07227.1 - 0.2 11.9 1.5 18 5.7 0.2 3.6 3 1 1 4 4 4 0 C4-type zinc ribbon domain Noc2 PF03715.13 EDO07228.1 - 8.3e-72 241.9 4.7 8.3e-72 241.9 4.7 2.2 2 0 0 2 2 2 1 Noc2p family zf-C3HC4_5 PF17121.5 EDO07228.1 - 0.16 11.9 1.1 8 6.4 0.0 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DNA_pol_B PF00136.21 EDO07229.1 - 2.4e-130 435.3 0.5 5.1e-130 434.2 0.5 1.5 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EDO07229.1 - 5.6e-71 239.4 0.2 9.6e-71 238.6 0.2 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EDO07229.1 - 1.8e-17 63.6 8.7 3.9e-17 62.5 8.7 1.6 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 EDO07229.1 - 0.0076 15.2 0.1 0.016 14.1 0.1 1.5 1 1 0 1 1 1 1 DNA polymerase type B, organellar and viral C6_DPF PF10170.9 EDO07229.1 - 0.29 11.5 2.3 0.92 9.9 2.3 1.8 1 0 0 1 1 1 0 Cysteine-rich domain RNase_PH PF01138.21 EDO07230.1 - 4.7e-12 46.6 0.0 7.3e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EDO07230.1 - 0.00022 21.2 0.0 0.00051 20.0 0.0 1.7 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Sec61_beta PF03911.16 EDO07233.1 - 3.3e-05 23.8 0.2 4.5e-05 23.4 0.2 1.2 1 0 0 1 1 1 1 Sec61beta family FRG PF08867.11 EDO07234.1 - 0.033 15.1 0.0 0.037 15.0 0.0 1.1 1 0 0 1 1 1 0 FRG domain Itfg2 PF15907.5 EDO07234.1 - 0.094 11.7 0.0 0.1 11.6 0.0 1.0 1 0 0 1 1 1 0 Integrin-alpha FG-GAP repeat-containing protein 2 CLP1_N PF16573.5 EDO07235.1 - 5.7e-18 64.9 0.0 1.1e-17 64.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor CLP1_P PF16575.5 EDO07235.1 - 3e-15 56.5 0.0 6.6e-14 52.1 0.0 2.7 2 1 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop DUF1611 PF07755.11 EDO07235.1 - 0.0071 15.6 0.0 0.014 14.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1611_C) P-loop domain KTI12 PF08433.10 EDO07235.1 - 0.0091 15.5 0.0 0.038 13.4 0.0 1.8 2 0 0 2 2 2 1 Chromatin associated protein KTI12 AAA_16 PF13191.6 EDO07235.1 - 0.021 15.2 0.0 0.045 14.1 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain Clp1 PF06807.14 EDO07235.1 - 0.028 14.9 0.0 0.15 12.5 0.0 2.2 2 0 0 2 2 2 0 Pre-mRNA cleavage complex II protein Clp1 AAA_28 PF13521.6 EDO07235.1 - 0.042 14.1 0.0 0.11 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain Ribosomal_L4 PF00573.22 EDO07238.1 - 9.2e-53 178.8 0.0 1.3e-52 178.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family SUD-M PF11633.8 EDO07239.1 - 0.11 12.2 0.0 0.69 9.6 0.0 2.1 2 1 0 2 2 2 0 Single-stranded poly(A) binding domain zf-CCCH PF00642.24 EDO07239.1 - 0.15 12.1 5.6 0.097 12.6 3.4 1.9 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) SUD-M PF11633.8 EDO07240.1 - 0.11 12.2 0.0 0.69 9.6 0.0 2.1 2 1 0 2 2 2 0 Single-stranded poly(A) binding domain zf-CCCH PF00642.24 EDO07240.1 - 0.15 12.1 5.6 0.097 12.6 3.4 1.9 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Med7 PF05983.11 EDO07241.1 - 1.3e-20 74.3 0.1 1.4e-20 74.2 0.1 1.0 1 0 0 1 1 1 1 MED7 protein AHD PF17793.1 EDO07241.1 - 0.016 15.0 0.0 0.41 10.5 0.0 2.6 2 1 1 3 3 3 0 ANC1 homology domain (AHD) KH_1 PF00013.29 EDO07242.1 - 1.6e-05 24.6 0.6 4.4e-05 23.2 0.6 1.7 1 0 0 1 1 1 1 KH domain Cyto_heme_lyase PF01265.17 EDO07243.1 - 3.7e-26 92.4 4.5 5.2e-18 65.6 1.7 3.3 1 1 1 2 2 2 2 Cytochrome c/c1 heme lyase zf-Tim10_DDP PF02953.15 EDO07244.1 - 1.5e-19 69.4 0.3 1.8e-19 69.1 0.3 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger eIF-5a PF01287.20 EDO07245.1 - 1.3e-26 92.5 0.2 1.8e-26 92.1 0.2 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 EDO07245.1 - 0.00019 21.4 0.2 0.0004 20.4 0.2 1.5 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain Rad17 PF03215.15 EDO07246.1 - 0.00034 20.6 0.0 0.0037 17.2 0.0 2.5 3 0 0 3 3 3 1 Rad17 P-loop domain AAA_16 PF13191.6 EDO07246.1 - 0.0064 16.9 0.0 0.015 15.7 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EDO07246.1 - 0.02 15.3 0.1 0.12 12.8 0.1 2.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDO07246.1 - 0.038 14.3 0.0 0.12 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EDO07246.1 - 0.088 13.4 0.0 1.3 9.5 0.0 2.6 2 1 0 2 2 2 0 AAA domain SKI PF01202.22 EDO07246.1 - 0.11 12.6 0.0 0.65 10.1 0.0 2.1 2 0 0 2 2 2 0 Shikimate kinase NACHT PF05729.12 EDO07246.1 - 0.18 11.7 0.0 0.42 10.5 0.0 1.7 1 0 0 1 1 1 0 NACHT domain TsaE PF02367.17 EDO07246.1 - 0.18 11.8 0.0 0.36 10.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 EDO07247.1 - 0.0038 17.0 0.0 0.0062 16.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain Rad51 PF08423.11 EDO07247.1 - 0.02 14.1 0.0 0.046 13.0 0.0 1.8 1 1 0 1 1 1 0 Rad51 GBP PF02263.19 EDO07247.1 - 0.1 11.8 0.2 0.17 11.1 0.2 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain ATPase PF06745.13 EDO07247.1 - 0.16 11.3 0.2 7.5 5.8 0.1 2.1 2 0 0 2 2 2 0 KaiC YtxH PF12732.7 EDO07248.1 - 0.017 15.7 10.0 14 6.3 5.4 4.1 2 2 0 2 2 2 0 YtxH-like protein HbrB PF08539.11 EDO07248.1 - 0.1 12.6 0.1 0.1 12.6 0.1 3.4 1 1 1 3 3 3 0 HbrB-like Anti-adapt_IraP PF10796.9 EDO07248.1 - 0.56 10.8 0.1 0.56 10.8 0.1 2.8 3 0 0 3 3 3 0 Sigma-S stabilisation anti-adaptor protein CK_II_beta PF01214.18 EDO07249.1 - 4.2e-69 232.0 1.0 5.1e-69 231.7 1.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit ADK_lid PF05191.14 EDO07249.1 - 0.066 13.2 0.7 0.17 11.9 0.7 1.7 1 0 0 1 1 1 0 Adenylate kinase, active site lid RIO1 PF01163.22 EDO07250.1 - 5.5e-56 189.1 0.0 1.1e-55 188.1 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Pkinase PF00069.25 EDO07250.1 - 0.018 14.4 0.1 0.073 12.4 0.0 2.0 2 0 0 2 2 2 0 Protein kinase domain APH PF01636.23 EDO07250.1 - 0.12 12.3 0.0 1.6 8.6 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family FAINT PF04385.15 EDO07251.1 - 0.075 13.1 0.1 0.075 13.1 0.1 2.2 2 1 0 2 2 2 0 Domain of unknown function, DUF529 FAM176 PF14851.6 EDO07251.1 - 0.59 9.8 2.6 1.1 8.9 2.0 1.7 2 0 0 2 2 2 0 FAM176 family RRM_1 PF00076.22 EDO07252.1 - 1.7e-31 107.8 0.9 4.5e-15 55.2 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO07252.1 - 1.7e-08 34.5 0.3 0.0032 17.6 0.1 2.7 2 2 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.11 EDO07252.1 - 0.0039 17.2 0.1 1.9 8.6 0.0 2.4 2 0 0 2 2 2 2 RNA binding motif OB_RNB PF08206.11 EDO07252.1 - 0.17 11.6 3.5 2.2 8.0 0.1 3.0 3 0 0 3 3 3 0 Ribonuclease B OB domain Ras PF00071.22 EDO07253.1 - 5.2e-59 198.5 0.0 6.2e-59 198.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO07253.1 - 2.4e-33 114.9 0.0 3.5e-33 114.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO07253.1 - 6.8e-12 45.2 0.1 7.7e-12 45.0 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EDO07253.1 - 7.3e-06 26.0 0.0 1.3e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EDO07253.1 - 6.7e-05 22.4 0.0 8.7e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EDO07253.1 - 0.00072 19.2 0.1 0.0053 16.3 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DNA_pol_E_B PF04042.16 EDO07253.1 - 0.0035 16.7 0.0 0.0048 16.3 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B RsgA_GTPase PF03193.16 EDO07253.1 - 0.0052 16.7 0.0 1 9.3 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_24 PF13479.6 EDO07253.1 - 0.011 15.5 0.4 0.047 13.4 0.1 1.9 1 1 1 2 2 2 0 AAA domain AAA_22 PF13401.6 EDO07253.1 - 0.03 14.6 0.0 0.071 13.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain Phage_Gp111 PF07410.11 EDO07253.1 - 0.13 12.7 0.2 0.23 12.0 0.2 1.4 1 0 0 1 1 1 0 Streptococcus thermophilus bacteriophage Gp111 protein Proteasome PF00227.26 EDO07254.1 - 1.7e-49 167.9 0.2 2e-49 167.7 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit CamS PF07537.11 EDO07254.1 - 0.12 11.5 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 CamS sex pheromone cAM373 precursor zf-RING_2 PF13639.6 EDO07255.1 - 3.6e-08 33.6 7.3 3.6e-08 33.6 7.3 2.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EDO07255.1 - 1.1e-07 31.6 5.2 1.1e-07 31.6 5.2 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDO07255.1 - 1.3e-06 28.1 8.7 3.4e-06 26.8 7.2 2.5 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDO07255.1 - 1.6e-06 28.0 5.0 1.7e-06 27.9 2.3 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EDO07255.1 - 1.6e-05 24.7 5.0 1.6e-05 24.7 5.0 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDO07255.1 - 4.2e-05 23.4 5.0 4.2e-05 23.4 5.0 2.0 2 1 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.7 EDO07255.1 - 0.00092 19.4 3.8 0.0024 18.1 3.8 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EDO07255.1 - 0.0016 18.5 7.2 0.0016 18.5 7.2 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 EDO07255.1 - 0.0026 17.8 1.7 0.0057 16.7 1.7 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.8 EDO07255.1 - 0.011 15.6 2.1 0.025 14.4 2.1 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 EDO07255.1 - 0.018 14.9 7.2 0.48 10.3 7.6 2.6 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 EDO07255.1 - 0.3 10.9 4.1 0.94 9.3 4.1 1.9 1 0 0 1 1 1 0 RING-like zinc finger KH_1 PF00013.29 EDO07257.1 - 1e-16 60.5 0.2 4.8e-09 35.9 0.0 4.7 5 0 0 5 5 5 3 KH domain SLS PF14611.6 EDO07257.1 - 0.00014 21.8 0.4 0.0075 16.1 0.1 3.0 1 1 2 3 3 3 1 Mitochondrial inner-membrane-bound regulator DUF2067 PF09840.9 EDO07257.1 - 0.047 13.3 0.2 11 5.6 0.0 3.8 3 1 1 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2067) KH_2 PF07650.17 EDO07257.1 - 0.057 13.3 1.0 0.13 12.1 0.0 2.1 2 0 0 2 2 2 0 KH domain UBA PF00627.31 EDO07258.1 - 2.5e-23 81.6 8.4 2e-11 43.5 0.9 3.1 3 0 0 3 3 3 2 UBA/TS-N domain XPC-binding PF09280.11 EDO07258.1 - 8e-21 73.5 6.0 1.5e-20 72.7 6.0 1.5 1 0 0 1 1 1 1 XPC-binding domain ubiquitin PF00240.23 EDO07258.1 - 5e-12 45.4 0.7 9.4e-12 44.5 0.7 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EDO07258.1 - 7.1e-05 22.6 0.5 0.00013 21.7 0.5 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EDO07258.1 - 0.002 18.7 0.3 0.0039 17.7 0.3 1.5 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain ALIX_LYPXL_bnd PF13949.6 EDO07258.1 - 0.0075 15.6 0.1 0.012 14.9 0.1 1.4 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV MDM1 PF15501.6 EDO07258.1 - 0.14 11.3 0.1 0.31 10.2 0.0 1.5 2 0 0 2 2 2 0 Nuclear protein MDM1 STI1 PF17830.1 EDO07258.1 - 2.5 8.1 5.0 0.83 9.6 1.4 2.2 2 1 0 2 2 2 0 STI1 domain RACo_linker PF17650.1 EDO07260.1 - 0.045 13.6 0.0 0.078 12.9 0.0 1.5 1 0 0 1 1 1 0 RACo linker region Tubulin PF00091.25 EDO07261.1 - 2.3e-41 142.2 0.1 5e-41 141.1 0.1 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EDO07261.1 - 0.00069 19.8 0.0 0.0016 18.6 0.0 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain DUF4047 PF13256.6 EDO07261.1 - 0.012 15.8 0.0 7.9 6.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) Tubulin_2 PF13809.6 EDO07261.1 - 0.088 12.0 0.6 0.16 11.1 0.3 1.6 1 1 1 2 2 2 0 Tubulin like SNF2_N PF00176.23 EDO07262.1 - 1.9e-58 197.9 0.4 1.9e-58 197.9 0.4 2.2 3 0 0 3 3 3 1 SNF2 family N-terminal domain Chromo PF00385.24 EDO07262.1 - 3.3e-21 75.0 8.1 1.9e-10 40.5 0.6 3.2 3 0 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 EDO07262.1 - 7.3e-21 74.6 0.1 5.4e-20 71.8 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 EDO07262.1 - 6.7e-11 41.9 0.2 2.4e-10 40.1 0.2 1.9 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 EDO07262.1 - 4.1e-07 29.9 0.0 1.8e-06 27.8 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF4208 PF13907.6 EDO07262.1 - 4.9e-05 23.7 0.3 0.00025 21.4 0.3 2.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4208) CDH1_2_SANT_HL1 PF18375.1 EDO07262.1 - 0.079 13.6 1.3 0.24 12.1 0.1 2.6 2 0 0 2 2 2 0 CDH1/2 SANT-Helical linker 1 Mtf2_C PF14061.6 EDO07262.1 - 0.085 13.0 0.6 0.26 11.5 0.1 2.1 2 0 0 2 2 2 0 Polycomb-like MTF2 factor 2 Thioredoxin PF00085.20 EDO07264.1 - 1.9e-27 95.3 0.0 5.2e-23 81.0 0.0 2.5 2 1 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 EDO07264.1 - 2.6e-09 37.2 0.0 0.00012 22.1 0.0 2.2 2 0 0 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EDO07264.1 - 1.2e-08 34.7 0.0 9.3e-08 31.8 0.0 2.0 1 1 1 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EDO07264.1 - 4e-08 33.7 0.3 0.00022 21.6 0.2 4.1 3 1 0 3 3 3 1 Thioredoxin-like domain TraF PF13728.6 EDO07264.1 - 8.9e-06 25.7 0.0 0.0004 20.3 0.0 2.8 3 0 0 3 3 3 1 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 EDO07264.1 - 0.00084 19.3 0.0 0.27 11.3 0.0 3.5 3 0 0 3 3 3 1 Thioredoxin domain Thioredoxin_8 PF13905.6 EDO07264.1 - 0.0018 18.6 0.1 0.16 12.3 0.0 3.2 2 1 1 3 3 3 1 Thioredoxin-like Thioredoxin_9 PF14595.6 EDO07264.1 - 0.03 14.1 0.0 0.056 13.2 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin GMP_synt_C PF00958.22 EDO07265.1 - 1.3e-30 105.3 0.1 2.7e-30 104.3 0.1 1.6 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 EDO07265.1 - 3.1e-15 56.5 0.0 5.8e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 EDO07265.1 - 1.7e-10 40.4 0.0 1.2e-08 34.4 0.0 2.3 2 0 0 2 2 2 1 NAD synthase Asn_synthase PF00733.21 EDO07265.1 - 0.0012 18.6 0.1 0.032 13.9 0.0 2.1 2 0 0 2 2 2 1 Asparagine synthase tRNA_Me_trans PF03054.16 EDO07265.1 - 0.0026 16.6 0.0 0.0047 15.8 0.0 1.3 1 0 0 1 1 1 1 tRNA methyl transferase QueC PF06508.13 EDO07265.1 - 0.019 14.4 0.1 0.071 12.6 0.0 2.0 3 0 0 3 3 3 0 Queuosine biosynthesis protein QueC PAPS_reduct PF01507.19 EDO07265.1 - 0.033 14.3 0.0 0.053 13.5 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Tubulin PF00091.25 EDO07265.1 - 0.062 13.5 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Tubulin/FtsZ family, GTPase domain UCR_14kD PF02271.16 EDO07266.1 - 2.6e-19 69.0 0.1 4e-19 68.4 0.1 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit PTH2 PF01981.16 EDO07267.1 - 5.7e-16 58.9 0.4 1.4e-15 57.6 0.4 1.7 1 1 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 TFIIS_C PF01096.18 EDO07268.1 - 1.8e-13 50.1 3.7 1.8e-13 50.1 3.7 2.4 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) GerD PF17898.1 EDO07268.1 - 0.11 12.5 0.0 12 5.9 0.0 2.4 2 0 0 2 2 2 0 Spore germination GerD central core domain DZR PF12773.7 EDO07268.1 - 1.8 8.6 9.0 6 7.0 1.0 2.6 2 1 0 2 2 2 0 Double zinc ribbon C1_4 PF07975.12 EDO07268.1 - 4.2 7.7 9.1 2.1 8.6 1.5 2.7 2 1 0 2 2 2 0 TFIIH C1-like domain Zn_Tnp_IS1595 PF12760.7 EDO07268.1 - 5.2 7.1 6.9 1.9 8.5 0.8 2.5 2 0 0 2 2 2 0 Transposase zinc-ribbon domain DUF2757 PF10955.8 EDO07268.1 - 7.8 6.8 8.6 22 5.4 0.9 4.0 4 1 0 4 4 4 0 Protein of unknown function (DUF2757) zinc_ribbon_15 PF17032.5 EDO07268.1 - 9.5 7.1 11.3 11 6.8 1.2 2.9 2 2 0 2 2 2 0 zinc-ribbon family Gar1 PF04410.14 EDO07269.1 - 3.5e-15 56.1 0.0 5.5e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region G-patch PF01585.23 EDO07270.1 - 1e-13 50.9 3.4 1.8e-13 50.1 3.4 1.4 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 EDO07270.1 - 0.0005 19.8 0.0 0.0016 18.2 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Gal_Lectin PF02140.18 EDO07271.1 - 0.59 10.6 7.2 0.11 12.9 1.7 2.5 2 0 0 2 2 2 0 Galactose binding lectin domain TPR_12 PF13424.6 EDO07272.1 - 6.3e-12 45.6 0.0 2.1e-10 40.7 0.0 2.4 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDO07272.1 - 3.6e-07 29.9 0.0 8.7e-05 22.4 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 EDO07272.1 - 0.00014 21.6 0.0 3.4 7.7 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDO07272.1 - 0.00081 19.1 0.0 0.03 14.1 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDO07272.1 - 0.018 15.1 0.0 0.18 12.0 0.0 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EDO07272.1 - 0.097 12.0 0.0 0.097 12.0 0.0 1.2 1 0 0 1 1 1 0 MalT-like TPR region EIF_2_alpha PF07541.12 EDO07273.1 - 2.5e-29 101.7 0.1 5.6e-29 100.6 0.0 1.6 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 EDO07273.1 - 5.8e-11 42.6 0.1 1.3e-10 41.4 0.1 1.6 1 0 0 1 1 1 1 S1 RNA binding domain Sigma70_ner PF04546.13 EDO07273.1 - 4.4 7.1 7.8 12 5.7 3.1 2.4 2 1 0 2 2 2 0 Sigma-70, non-essential region HEAT_EZ PF13513.6 EDO07274.1 - 0.14 12.7 0.1 0.75 10.4 0.1 2.3 1 0 0 1 1 1 0 HEAT-like repeat SRP54 PF00448.22 EDO07275.1 - 1.7e-75 253.0 0.5 3e-75 252.2 0.5 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EDO07275.1 - 2e-27 95.7 7.8 2.9e-27 95.2 0.0 3.3 3 0 0 3 3 3 1 Signal peptide binding domain SRP54_N PF02881.19 EDO07275.1 - 3.5e-16 59.2 2.9 3.5e-16 59.2 2.9 2.7 3 0 0 3 3 2 1 SRP54-type protein, helical bundle domain cobW PF02492.19 EDO07275.1 - 8.3e-06 25.5 0.1 4.1e-05 23.2 0.1 2.0 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ResIII PF04851.15 EDO07275.1 - 0.00014 21.9 0.6 0.00045 20.3 0.6 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit MeaB PF03308.16 EDO07275.1 - 0.00019 20.5 0.0 0.00085 18.4 0.0 2.0 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Phage_TAC_5 PF08890.11 EDO07275.1 - 0.00028 20.9 0.1 0.0009 19.3 0.0 1.9 2 0 0 2 2 1 1 Phage XkdN-like tail assembly chaperone protein, TAC AAA_33 PF13671.6 EDO07275.1 - 0.00057 20.1 0.0 0.0015 18.7 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_16 PF13191.6 EDO07275.1 - 0.00066 20.1 0.0 0.0021 18.4 0.0 1.8 1 1 1 2 2 2 1 AAA ATPase domain Zeta_toxin PF06414.12 EDO07275.1 - 0.0012 18.2 0.0 0.0023 17.2 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin CbiA PF01656.23 EDO07275.1 - 0.0024 17.9 0.0 0.0076 16.3 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_22 PF13401.6 EDO07275.1 - 0.0032 17.7 1.0 0.013 15.7 0.0 2.6 4 0 0 4 4 2 1 AAA domain DRE2_N PF16803.5 EDO07275.1 - 0.0036 17.6 2.6 3.6 7.8 0.0 3.5 4 1 0 4 4 3 1 Fe-S cluster assembly protein DRE2 N-terminus Fe-ADH PF00465.19 EDO07275.1 - 0.005 15.7 0.3 0.014 14.2 0.0 1.8 2 0 0 2 2 2 1 Iron-containing alcohol dehydrogenase ATPase PF06745.13 EDO07275.1 - 0.0083 15.5 0.1 0.0083 15.5 0.1 2.5 4 0 0 4 4 4 1 KaiC AAA_17 PF13207.6 EDO07275.1 - 0.009 16.4 0.2 0.009 16.4 0.2 2.5 3 1 0 3 3 2 1 AAA domain SRPRB PF09439.10 EDO07275.1 - 0.0098 15.3 0.7 1.6 8.1 0.7 2.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit APS_kinase PF01583.20 EDO07275.1 - 0.011 15.7 0.0 0.028 14.3 0.0 1.7 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_31 PF13614.6 EDO07275.1 - 0.011 15.7 0.3 0.46 10.4 0.0 2.6 1 1 1 2 2 2 0 AAA domain AAA_30 PF13604.6 EDO07275.1 - 0.012 15.3 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EDO07275.1 - 0.019 15.0 1.4 0.21 11.7 0.2 3.1 3 1 0 3 3 2 0 50S ribosome-binding GTPase DUF2209 PF09974.9 EDO07275.1 - 0.02 15.2 0.2 0.089 13.1 0.2 2.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) AAA_24 PF13479.6 EDO07275.1 - 0.049 13.4 0.1 0.14 11.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EDO07275.1 - 0.049 13.9 0.2 0.15 12.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.17 EDO07275.1 - 0.064 12.9 0.2 0.61 9.7 0.0 2.4 2 0 0 2 2 2 0 Thymidylate kinase MobB PF03205.14 EDO07275.1 - 0.066 13.1 0.0 0.2 11.6 0.0 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Ribosomal_L17 PF01196.19 EDO07275.1 - 0.073 14.0 0.2 0.34 11.8 0.0 2.2 2 0 0 2 2 1 0 Ribosomal protein L17 AAA PF00004.29 EDO07275.1 - 0.084 13.3 0.2 1.4 9.3 0.1 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF373 PF04123.13 EDO07275.1 - 0.1 12.0 0.8 0.18 11.2 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF373) Roc PF08477.13 EDO07275.1 - 0.12 12.6 0.4 1.7 8.9 0.1 2.6 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 EDO07275.1 - 0.23 11.2 2.9 2.9 7.6 0.1 3.2 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation ArsA_ATPase PF02374.15 EDO07275.1 - 0.52 9.5 6.0 0.67 9.1 0.0 3.2 2 2 0 3 3 3 0 Anion-transporting ATPase LPD14 PF18827.1 EDO07275.1 - 0.8 10.0 0.0 0.8 10.0 0.0 2.9 4 1 0 4 4 3 0 Large polyvalent protein-associated domain 14 KH_1 PF00013.29 EDO07276.1 - 7.4e-06 25.7 0.0 0.029 14.2 0.0 2.3 2 0 0 2 2 2 2 KH domain XPG_I PF00867.18 EDO07277.1 - 5.3e-09 36.3 2.3 2.6e-08 34.1 0.4 2.5 3 0 0 3 3 3 1 XPG I-region 5_3_exonuc PF01367.20 EDO07277.1 - 3.7e-05 24.2 0.0 6.1e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 EDO07277.1 - 0.0088 16.6 0.0 0.017 15.7 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.7 EDO07277.1 - 0.029 14.4 0.0 0.087 12.9 0.0 1.8 2 0 0 2 2 2 0 Helix-hairpin-helix motif mTERF PF02536.14 EDO07278.1 - 4.2e-16 58.8 0.0 7.5e-16 57.9 0.0 1.3 1 0 0 1 1 1 1 mTERF DUF483 PF04467.12 EDO07278.1 - 0.026 14.5 0.2 0.076 13.0 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF483) PH_11 PF15413.6 EDO07278.1 - 0.21 12.0 1.0 1.7 9.1 0.5 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain Syntaxin-6_N PF09177.11 EDO07282.1 - 2.5e-14 53.6 2.7 4.4e-14 52.8 0.5 2.0 2 0 0 2 2 2 1 Syntaxin 6, N-terminal ArsR PF09824.9 EDO07282.1 - 0.0036 16.9 3.9 0.13 11.8 0.2 2.3 1 1 1 2 2 2 2 ArsR transcriptional regulator NIT PF08376.10 EDO07282.1 - 0.017 15.6 0.7 0.021 15.3 0.7 1.2 1 0 0 1 1 1 0 Nitrate and nitrite sensing DHR10 PF18595.1 EDO07282.1 - 0.028 14.5 0.4 0.028 14.5 0.4 2.9 3 1 0 3 3 3 0 Designed helical repeat protein 10 domain Phage_HK97_TLTM PF06120.11 EDO07282.1 - 0.19 10.9 6.6 0.24 10.6 6.6 1.1 1 0 0 1 1 1 0 Tail length tape measure protein GIT_CC PF16559.5 EDO07282.1 - 0.22 11.4 0.0 0.22 11.4 0.0 2.4 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor HrpB7 PF09486.10 EDO07282.1 - 0.58 10.5 8.0 4.3 7.7 0.2 2.7 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) Fib_alpha PF08702.10 EDO07282.1 - 3.2 7.9 12.4 3 8.0 4.0 2.9 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family AAA PF00004.29 EDO07283.1 - 8.4e-43 146.0 0.0 1.9e-42 144.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EDO07283.1 - 3.2e-11 43.0 0.0 6.9e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EDO07283.1 - 2.3e-10 40.1 0.5 4.4e-10 39.2 0.5 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 EDO07283.1 - 4.1e-06 27.0 0.0 8.9e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EDO07283.1 - 7.9e-06 26.2 0.1 0.0069 16.7 0.1 2.6 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EDO07283.1 - 1e-05 25.5 0.1 6.1e-05 23.0 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDO07283.1 - 3.7e-05 24.2 0.0 0.0012 19.3 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 EDO07283.1 - 4.2e-05 22.8 0.0 7.1e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EDO07283.1 - 4.9e-05 23.1 0.0 0.0001 22.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 EDO07283.1 - 0.00024 20.9 0.0 0.0005 19.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 EDO07283.1 - 0.0036 17.7 0.0 0.0079 16.6 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_33 PF13671.6 EDO07283.1 - 0.0049 17.0 0.0 0.0096 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EDO07283.1 - 0.006 16.5 0.0 0.61 10.0 0.0 3.0 2 1 1 3 3 3 1 NACHT domain AAA_18 PF13238.6 EDO07283.1 - 0.0061 17.1 0.0 0.012 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EDO07283.1 - 0.0071 16.6 0.0 0.015 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EDO07283.1 - 0.0078 16.3 0.0 0.016 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 EDO07283.1 - 0.01 15.1 0.0 0.022 14.0 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 EDO07283.1 - 0.014 14.8 0.0 0.029 13.8 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PhoH PF02562.16 EDO07283.1 - 0.025 14.1 0.2 0.11 11.9 0.1 2.0 2 0 0 2 2 2 0 PhoH-like protein AAA_24 PF13479.6 EDO07283.1 - 0.038 13.7 0.2 0.089 12.5 0.2 1.7 1 1 0 1 1 1 0 AAA domain Prot_ATP_OB_N PF17758.1 EDO07283.1 - 0.04 13.6 0.0 0.15 11.8 0.0 1.9 2 0 0 2 2 2 0 Proteasomal ATPase OB N-terminal domain AAA_25 PF13481.6 EDO07283.1 - 0.046 13.3 0.3 0.17 11.4 0.1 2.0 1 1 1 2 2 2 0 AAA domain ATPase PF06745.13 EDO07283.1 - 0.067 12.5 0.0 0.42 9.9 0.0 2.2 2 0 0 2 2 2 0 KaiC AAA_7 PF12775.7 EDO07283.1 - 0.12 11.9 0.0 0.36 10.3 0.0 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_3 PF07726.11 EDO07283.1 - 0.13 12.1 0.0 0.33 10.8 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 EDO07283.1 - 0.14 12.1 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 EDO07283.1 - 0.16 11.0 0.0 0.28 10.2 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Sigma54_activat PF00158.26 EDO07283.1 - 0.19 11.4 0.1 1.3 8.7 0.0 2.3 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_30 PF13604.6 EDO07283.1 - 0.2 11.3 0.1 0.57 9.9 0.1 1.7 1 1 0 1 1 1 0 AAA domain UQ_con PF00179.26 EDO07284.1 - 1.6e-18 66.7 0.0 3.3e-18 65.7 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Nup54 PF13874.6 EDO07284.1 - 1.8e-10 41.1 0.8 4.5e-10 39.8 0.3 1.8 1 1 1 2 2 2 1 Nucleoporin complex subunit 54 Hrs_helical PF12210.8 EDO07284.1 - 0.011 16.2 1.4 2.8 8.5 0.3 2.6 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Med28 PF11594.8 EDO07284.1 - 0.068 13.3 0.2 0.26 11.4 0.2 2.0 1 0 0 1 1 1 0 Mediator complex subunit 28 ATG16 PF08614.11 EDO07284.1 - 0.16 12.2 6.8 0.49 10.6 6.8 1.9 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) LMBR1 PF04791.16 EDO07284.1 - 0.3 9.9 3.5 0.12 11.2 1.2 1.5 1 1 0 1 1 1 0 LMBR1-like membrane protein CCDC-167 PF15188.6 EDO07284.1 - 8 6.9 7.5 1.6 9.1 0.9 2.6 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 XRN_N PF03159.18 EDO07285.1 - 4.9e-61 206.2 0.0 6.7e-61 205.8 0.0 1.2 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 EDO07285.1 - 1.2e-32 113.5 4.5 3.3e-16 59.3 0.0 3.2 1 1 2 3 3 3 3 Xrn1 helical domain CbiK PF06180.11 EDO07285.1 - 0.12 11.7 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Cobalt chelatase (CbiK) Mtd_N PF18454.1 EDO07285.1 - 0.17 11.9 0.0 0.46 10.5 0.0 1.6 1 0 0 1 1 1 0 Major tropism determinant N-terminal domain Antifungal_prot PF11402.8 EDO07285.1 - 0.58 10.4 3.5 0.33 11.2 0.4 2.1 2 0 0 2 2 2 0 Antifungal protein Transglut_core PF01841.19 EDO07286.1 - 0.0052 17.2 0.0 0.0082 16.6 0.0 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily Flavodoxin_1 PF00258.25 EDO07289.1 - 9.5e-15 55.1 0.0 2.5e-14 53.7 0.0 1.7 2 0 0 2 2 2 1 Flavodoxin FAD_binding_1 PF00667.20 EDO07289.1 - 4e-13 49.5 0.0 8.8e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain zf-C3HC4_3 PF13920.6 EDO07290.1 - 0.0037 17.1 14.7 0.0037 17.1 14.7 3.0 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDO07291.1 - 8e-06 25.8 4.6 2.5e-05 24.2 4.6 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EDO07291.1 - 0.00013 22.0 5.1 0.00022 21.3 3.9 2.1 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EDO07291.1 - 0.00033 20.4 8.0 0.0011 18.8 7.9 1.9 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EDO07291.1 - 0.00046 20.0 4.0 0.001 18.9 4.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDO07291.1 - 0.0011 18.8 6.4 0.0027 17.5 6.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDO07291.1 - 0.0023 18.2 6.3 0.0057 17.0 6.3 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EDO07291.1 - 0.0023 17.8 8.0 0.0065 16.4 8.0 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EDO07291.1 - 0.062 13.1 6.0 0.15 11.9 6.0 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) AAA_6 PF12774.7 EDO07292.1 - 1.7e-74 250.8 0.0 1.5e-73 247.6 0.0 2.8 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EDO07292.1 - 7.8e-39 133.9 6.3 7.8e-39 133.9 6.3 3.5 5 0 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 MT PF12777.7 EDO07292.1 - 8.8e-20 71.0 14.6 1.3e-19 70.5 13.0 2.1 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 EDO07292.1 - 7e-09 35.8 0.0 2.9e-08 33.8 0.0 2.1 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain AAA PF00004.29 EDO07292.1 - 3.9e-06 27.3 0.1 0.23 11.9 0.0 4.0 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EDO07292.1 - 4.5e-06 26.3 0.1 0.019 14.5 0.0 3.6 3 0 0 3 3 3 2 P-loop containing dynein motor region AAA_5 PF07728.14 EDO07292.1 - 8e-06 25.9 0.2 0.12 12.4 0.0 4.3 5 0 0 5 5 4 2 AAA domain (dynein-related subfamily) AAA_9 PF12781.7 EDO07292.1 - 0.0001 21.5 1.0 0.0001 21.5 1.0 4.5 4 0 0 4 4 3 1 ATP-binding dynein motor region AAA_lid_11 PF18198.1 EDO07292.1 - 0.00014 21.8 0.2 0.00014 21.8 0.2 2.7 3 0 0 3 3 2 1 Dynein heavy chain AAA lid domain AAA_30 PF13604.6 EDO07292.1 - 0.0028 17.4 0.0 1.6 8.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EDO07292.1 - 0.024 15.0 0.0 5.2 7.4 0.0 2.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_24 PF13479.6 EDO07292.1 - 0.054 13.2 0.9 11 5.6 0.0 3.4 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.6 EDO07292.1 - 0.12 12.6 6.7 3.8 7.8 0.0 5.4 5 0 0 5 5 5 0 AAA domain AAA_19 PF13245.6 EDO07292.1 - 0.19 12.1 0.4 10 6.5 0.0 3.3 3 0 0 3 3 3 0 AAA domain DUF220 PF02713.14 EDO07292.1 - 0.25 11.5 1.8 1.3 9.2 1.8 2.3 1 0 0 1 1 1 0 Domain of unknown function DUF220 AAA_18 PF13238.6 EDO07292.1 - 0.58 10.7 3.7 49 4.5 0.0 4.8 4 0 0 4 4 3 0 AAA domain ERM PF00769.19 EDO07292.1 - 6.3 6.5 14.4 12 5.6 0.6 2.4 2 0 0 2 2 2 0 Ezrin/radixin/moesin family BaxI_1 PF12811.7 EDO07293.1 - 0.17 11.4 0.0 0.21 11.1 0.0 1.1 1 0 0 1 1 1 0 Bax inhibitor 1 like Adaptin_N PF01602.20 EDO07294.1 - 1.7e-56 191.9 13.7 2.2e-56 191.5 13.7 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EDO07294.1 - 4.1e-15 56.2 8.2 5.3e-14 52.6 1.7 3.8 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 API5 PF05918.11 EDO07294.1 - 0.00046 19.1 0.9 0.00079 18.4 0.9 1.3 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) HEAT_2 PF13646.6 EDO07294.1 - 0.0018 18.6 0.0 0.52 10.7 0.0 3.3 2 1 2 4 4 4 2 HEAT repeats HEAT PF02985.22 EDO07294.1 - 0.14 12.5 2.1 85 3.8 0.0 4.0 4 0 0 4 4 4 0 HEAT repeat FtsJ PF01728.19 EDO07295.1 - 4.8e-64 215.7 0.2 6.1e-64 215.4 0.2 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase NinF PF05810.12 EDO07295.1 - 0.27 11.1 0.1 0.27 11.1 0.1 2.0 2 0 0 2 2 2 0 NinF protein Brix PF04427.18 EDO07296.1 - 9.5e-25 87.8 0.1 1.5e-24 87.2 0.1 1.3 1 0 0 1 1 1 1 Brix domain NMD3 PF04981.13 EDO07297.1 - 9.7e-62 208.6 16.4 1.6e-61 207.9 16.4 1.4 1 0 0 1 1 1 1 NMD3 family RRT14 PF17075.5 EDO07297.1 - 0.34 11.0 3.5 0.85 9.7 3.5 1.7 1 0 0 1 1 1 0 Regular of rDNA transcription protein 14 C1_1 PF00130.22 EDO07297.1 - 1.2 9.1 14.8 18 5.3 10.0 3.2 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) SRP9-21 PF05486.12 EDO07298.1 - 2.8e-07 30.8 0.4 3e-05 24.3 0.4 2.3 1 1 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) IL17R_fnIII_D1 PF16556.5 EDO07298.1 - 0.03 13.9 0.1 0.035 13.8 0.1 1.1 1 0 0 1 1 1 0 Interleukin-17 receptor, fibronectin-III-like domain 1 RRM_1 PF00076.22 EDO07299.1 - 1.6e-08 34.2 0.2 2.3e-05 24.1 0.1 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO07299.1 - 0.0097 16.0 0.0 0.026 14.6 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif RabGAP-TBC PF00566.18 EDO07301.1 - 4.9e-11 42.7 1.0 7e-11 42.2 0.2 1.6 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Rhodanese PF00581.20 EDO07301.1 - 0.0054 17.2 0.0 0.01 16.4 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain Pkinase PF00069.25 EDO07302.1 - 6.7e-13 48.6 0.4 5.5e-12 45.6 0.4 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO07302.1 - 2.2e-08 33.7 0.0 4.4e-07 29.4 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO07302.1 - 0.0048 16.3 0.0 0.052 12.9 0.0 2.0 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 EDO07302.1 - 0.14 11.5 0.2 0.27 10.6 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SspK PF08176.12 EDO07303.1 - 0.038 14.3 0.1 16 5.8 0.0 3.4 3 0 0 3 3 3 0 Small acid-soluble spore protein K family DEAD PF00270.29 EDO07304.1 - 3.3e-42 144.2 0.1 5.7e-42 143.5 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO07304.1 - 9.9e-22 77.4 0.1 2.2e-19 69.8 0.0 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EDO07304.1 - 2e-13 50.3 0.1 4.3e-13 49.3 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EDO07304.1 - 5.4e-06 26.5 0.0 1.1e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Nse4_C PF08743.10 EDO07305.1 - 5e-07 29.9 0.0 1.3e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 Nse4 C-terminal PI3_PI4_kinase PF00454.27 EDO07306.1 - 6.1e-36 124.5 0.1 2.4e-26 93.0 0.1 2.6 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EDO07306.1 - 8.7e-09 35.0 0.5 1.8e-08 34.0 0.5 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) tRNA-synt_2 PF00152.20 EDO07307.1 - 1.2e-63 215.1 0.0 3e-63 213.8 0.0 1.6 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 EDO07307.1 - 0.00059 19.4 0.0 0.031 13.8 0.0 2.6 3 0 0 3 3 3 1 tRNA synthetases class II core domain (F) tRNA_anti-codon PF01336.25 EDO07307.1 - 0.0092 15.9 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain HHH_5 PF14520.6 EDO07308.1 - 0.14 12.8 0.0 0.35 11.5 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix domain Pro_isomerase PF00160.21 EDO07309.1 - 1.2e-50 171.8 0.0 2.5e-50 170.8 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 EDO07309.1 - 2e-06 28.4 0.1 0.78 10.7 0.1 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EDO07309.1 - 0.00019 20.5 0.2 0.0078 15.2 0.0 2.6 3 0 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 EDO07309.1 - 0.0083 16.4 0.0 0.14 12.5 0.0 2.8 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain zf-CCCH PF00642.24 EDO07310.1 - 0.0031 17.4 0.1 0.0031 17.4 0.1 4.5 4 0 0 4 4 4 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDO07310.1 - 0.0065 16.5 0.5 0.0065 16.5 0.5 4.6 5 0 0 5 5 5 1 Zinc finger domain zf-CCCH_3 PF15663.5 EDO07310.1 - 0.024 14.9 0.9 0.024 14.9 0.9 2.4 2 0 0 2 2 2 0 Zinc-finger containing family zf-CCCH_4 PF18044.1 EDO07310.1 - 0.038 13.8 14.8 0.048 13.5 0.1 4.1 4 0 0 4 4 4 0 CCCH-type zinc finger zf-CCCH PF00642.24 EDO07311.1 - 1.8e-09 37.3 2.6 3.3e-09 36.4 2.6 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-RING_5 PF14634.6 EDO07311.1 - 4.7e-06 26.5 7.5 8.6e-06 25.6 7.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf_CCCH_4 PF18345.1 EDO07311.1 - 7.2e-06 25.9 4.5 1.5e-05 24.9 4.5 1.6 1 0 0 1 1 1 1 Zinc finger domain zf-C3HC4_3 PF13920.6 EDO07311.1 - 5.3e-05 23.0 6.3 0.00012 21.9 6.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDO07311.1 - 0.00012 21.8 9.3 0.00027 20.8 9.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH_4 PF18044.1 EDO07311.1 - 0.00023 20.9 2.8 0.00023 20.9 2.8 2.2 2 0 0 2 2 2 1 CCCH-type zinc finger zf-RING_10 PF16685.5 EDO07311.1 - 0.00058 20.0 5.1 0.00071 19.7 3.5 1.9 2 0 0 2 2 2 1 zinc RING finger of MSL2 zf-C3HC4_2 PF13923.6 EDO07311.1 - 0.00081 19.2 7.7 0.0018 18.1 7.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDO07311.1 - 0.0032 17.5 5.6 0.0073 16.3 5.6 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EDO07311.1 - 0.0037 17.6 7.0 0.0083 16.4 7.0 1.6 1 0 0 1 1 1 1 Ring finger domain SR-25 PF10500.9 EDO07311.1 - 0.048 13.3 10.3 0.092 12.3 10.3 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RP-C_C PF11800.8 EDO07311.1 - 0.058 13.5 1.6 0.1 12.7 1.6 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region Prok-RING_4 PF14447.6 EDO07311.1 - 0.062 13.2 4.9 0.13 12.1 4.9 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-CCCH_2 PF14608.6 EDO07311.1 - 0.21 12.1 2.7 0.52 10.9 2.7 1.7 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf-C3HC4_4 PF15227.6 EDO07311.1 - 0.8 9.9 8.5 1.2 9.4 6.9 2.2 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Slu7 PF11708.8 EDO07311.1 - 2.4 7.8 13.9 0.16 11.7 8.4 1.7 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor AF-4 PF05110.13 EDO07311.1 - 5.7 4.9 17.4 0.62 8.1 13.0 1.5 2 0 0 2 2 2 0 AF-4 proto-oncoprotein CoaE PF01121.20 EDO07312.1 - 1.1e-39 136.0 0.1 6.9e-39 133.4 0.1 1.9 1 1 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 EDO07312.1 - 3.6e-05 24.3 0.1 0.00021 21.8 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDO07312.1 - 0.00031 20.9 0.0 0.0013 18.9 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EDO07312.1 - 0.00042 20.6 0.0 0.00075 19.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain dNK PF01712.19 EDO07312.1 - 0.012 15.4 0.0 0.026 14.4 0.0 1.5 1 0 0 1 1 1 0 Deoxynucleoside kinase ABC_tran PF00005.27 EDO07312.1 - 0.025 15.1 0.0 0.062 13.8 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 EDO07312.1 - 0.025 14.3 0.1 0.057 13.2 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Cytidylate_kin2 PF13189.6 EDO07312.1 - 0.054 13.6 0.4 1.7 8.7 0.2 2.4 2 1 0 2 2 2 0 Cytidylate kinase-like family SKI PF01202.22 EDO07312.1 - 0.06 13.5 0.0 0.23 11.6 0.0 1.9 2 0 0 2 2 2 0 Shikimate kinase ATP_bind_2 PF03668.15 EDO07312.1 - 0.079 12.3 0.2 0.17 11.2 0.1 1.5 2 0 0 2 2 2 0 P-loop ATPase protein family Cytidylate_kin PF02224.18 EDO07312.1 - 0.12 12.1 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA_24 PF13479.6 EDO07312.1 - 0.17 11.6 0.0 0.3 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EDO07312.1 - 0.2 10.9 0.0 0.29 10.4 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin ArfGap PF01412.18 EDO07313.1 - 1.9e-30 105.3 2.2 4.2e-30 104.2 0.0 2.2 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf RNA_pol_Rpb1_5 PF04998.17 EDO07314.1 - 6.3e-85 284.8 0.0 1.4e-84 283.7 0.0 1.6 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EDO07314.1 - 1.3e-59 201.2 0.0 2.4e-59 200.3 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EDO07314.1 - 3.4e-27 95.3 0.0 1.2e-26 93.6 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EDO07314.1 - 5.7e-15 55.2 0.1 1.4e-14 53.9 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_1 PF04997.12 EDO07314.1 - 3.2e-14 53.0 1.5 7.7e-11 41.9 0.2 2.6 2 0 0 2 2 2 2 RNA polymerase Rpb1, domain 1 AAA_13 PF13166.6 EDO07314.1 - 0.074 11.7 0.4 0.12 11.0 0.4 1.2 1 0 0 1 1 1 0 AAA domain DUF787 PF05619.11 EDO07314.1 - 0.075 12.2 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF787) Nop14 PF04147.12 EDO07314.1 - 3 5.9 12.1 4.4 5.4 12.1 1.1 1 0 0 1 1 1 0 Nop14-like family Ufd2P_core PF10408.9 EDO07315.1 - 2.2e-136 456.1 21.5 3.1e-136 455.6 21.5 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 EDO07315.1 - 4.1e-24 84.5 1.2 1.1e-23 83.1 1.2 1.8 1 0 0 1 1 1 1 U-box domain PHO4 PF01384.20 EDO07316.1 - 0.23 10.5 8.8 1.8 7.5 3.7 2.8 1 1 1 2 2 2 0 Phosphate transporter family FAM176 PF14851.6 EDO07316.1 - 5.3 6.7 10.1 1.5 8.5 4.9 2.7 2 0 0 2 2 2 0 FAM176 family LSM PF01423.22 EDO07317.1 - 1.8e-21 75.6 0.1 2e-21 75.4 0.1 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EDO07317.1 - 0.0024 18.0 0.0 0.0028 17.7 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF150_C PF17384.2 EDO07317.1 - 0.08 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 RimP C-terminal SH3 domain SNF2_N PF00176.23 EDO07318.1 - 7.6e-54 182.7 0.0 1.5e-53 181.8 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDO07318.1 - 2.5e-15 56.8 0.0 5.9e-15 55.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO07318.1 - 2.2e-12 47.3 0.3 8e-12 45.5 0.0 2.1 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDO07318.1 - 2.5e-05 24.1 0.0 5e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2075 PF09848.9 EDO07318.1 - 0.0031 16.8 0.0 0.0097 15.2 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) SWI2_SNF2 PF18766.1 EDO07318.1 - 0.0079 15.9 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 SWI2/SNF2 ATPase HDA2-3 PF11496.8 EDO07318.1 - 0.021 14.0 3.3 0.041 13.0 0.0 2.7 3 1 0 3 3 3 0 Class II histone deacetylase complex subunits 2 and 3 PH_13 PF16652.5 EDO07318.1 - 0.088 12.6 0.0 0.23 11.3 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain UQ_con PF00179.26 EDO07319.1 - 1.6e-37 128.3 0.1 2.2e-37 127.9 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Asp PF00026.23 EDO07320.1 - 1.3e-37 130.0 2.5 7.3e-25 88.0 0.0 2.4 2 1 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDO07320.1 - 0.0021 18.3 0.7 0.32 11.2 0.0 3.0 3 1 1 4 4 4 2 Xylanase inhibitor N-terminal Ribosomal_L1 PF00687.21 EDO07321.1 - 1.9e-41 142.1 0.6 3.2e-41 141.3 0.3 1.4 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family FAST_1 PF06743.15 EDO07322.1 - 2.4e-05 24.2 3.0 1.3 9.0 0.0 4.6 4 0 0 4 4 4 3 FAST kinase-like protein, subdomain 1 Barttin PF15462.6 EDO07322.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) zf-Tim10_DDP PF02953.15 EDO07323.1 - 5e-19 67.7 2.3 7e-19 67.2 2.3 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger SPK PF04435.18 EDO07323.1 - 0.036 14.5 0.6 0.044 14.2 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF545) NAGLU PF05089.12 EDO07323.1 - 0.048 12.6 0.1 0.055 12.4 0.1 1.0 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain Suv3_N PF18114.1 EDO07323.1 - 0.067 13.3 0.1 0.076 13.1 0.1 1.2 1 0 0 1 1 1 0 Suv3 helical N-terminal domain Antimicrobial17 PF08129.11 EDO07324.1 - 0.028 14.4 0.0 0.074 13.1 0.0 1.7 1 0 0 1 1 1 0 Alpha/beta enterocin family Integrase_H2C2 PF17921.1 EDO07324.1 - 0.56 10.4 1.8 8.5 6.6 0.1 2.3 2 0 0 2 2 2 0 Integrase zinc binding domain G-patch PF01585.23 EDO07325.1 - 1.5e-14 53.6 2.0 3.5e-14 52.4 2.0 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EDO07325.1 - 3.4e-06 27.1 0.3 3.4e-06 27.1 0.3 2.1 2 1 0 2 2 2 1 G-patch domain PRP1_N PF06424.12 EDO07326.1 - 4.8e-37 127.6 18.7 1.6e-29 103.2 11.0 3.6 2 1 0 2 2 2 2 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 EDO07326.1 - 5.4e-28 95.3 28.6 0.021 15.6 0.0 14.9 8 4 9 17 17 17 8 Tetratricopeptide repeat TPR_19 PF14559.6 EDO07326.1 - 9.4e-22 77.3 15.0 0.021 15.4 0.0 9.3 7 3 2 9 9 9 7 Tetratricopeptide repeat TPR_17 PF13431.6 EDO07326.1 - 2.2e-07 30.8 2.1 0.51 10.8 0.0 6.8 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDO07326.1 - 6.7e-05 22.7 13.8 0.52 10.5 0.0 8.6 9 0 0 9 9 8 2 Tetratricopeptide repeat DUF3808 PF10300.9 EDO07326.1 - 0.00014 20.8 0.5 0.27 9.9 0.0 3.6 3 1 0 3 3 3 2 Protein of unknown function (DUF3808) Suf PF05843.14 EDO07326.1 - 0.0011 19.1 0.1 9.3 6.1 0.0 5.2 6 1 0 6 6 6 1 Suppressor of forked protein (Suf) TPR_1 PF00515.28 EDO07326.1 - 0.0031 17.2 1.0 0.35 10.8 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDO07326.1 - 0.016 15.8 12.1 0.96 10.2 0.1 6.7 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_9 PF13371.6 EDO07326.1 - 0.038 14.1 2.6 0.33 11.1 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 EDO07326.1 - 0.057 13.7 8.2 2.5 8.4 0.0 6.0 6 1 0 6 6 6 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EDO07326.1 - 0.099 12.7 0.1 1.7 8.7 0.0 2.9 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_21 PF09976.9 EDO07326.1 - 0.17 11.6 11.1 0.19 11.4 0.5 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat-like domain TPR_7 PF13176.6 EDO07326.1 - 0.87 9.8 4.0 5.8 7.2 0.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat Bac_RepA_C PF18008.1 EDO07327.1 - 0.026 14.9 0.1 0.11 12.9 0.1 2.1 1 0 0 1 1 1 0 Replication initiator protein A C-terminal domain Vps35 PF03635.17 EDO07328.1 - 8.9e-168 560.1 11.7 1.2e-167 559.7 11.7 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Methyltr_RsmB-F PF01189.17 EDO07331.1 - 1.5e-09 37.8 0.0 1.7e-07 31.1 0.0 2.5 1 1 1 2 2 2 2 16S rRNA methyltransferase RsmB/F Es2 PF09751.9 EDO07332.1 - 1.8e-21 77.4 9.2 3e-12 47.0 0.1 3.2 1 1 1 3 3 3 3 Nuclear protein Es2 Actin PF00022.19 EDO07333.1 - 6.7e-70 235.7 0.0 8.9e-69 232.0 0.0 1.9 1 1 0 1 1 1 1 Actin FtsA PF14450.6 EDO07333.1 - 0.071 13.5 0.0 0.1 13.0 0.0 1.4 1 1 0 1 1 1 0 Cell division protein FtsA Ribonuc_red_lgC PF02867.15 EDO07333.1 - 0.18 10.3 0.0 0.22 10.0 0.0 1.1 1 0 0 1 1 1 0 Ribonucleotide reductase, barrel domain Ribosomal_L11 PF00298.19 EDO07334.1 - 1.9e-20 73.2 0.0 3e-20 72.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 EDO07334.1 - 2e-18 66.0 0.0 3.4e-18 65.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Gcd10p PF04189.13 EDO07335.1 - 6.1e-42 143.8 0.1 6.9e-42 143.6 0.1 1.1 1 0 0 1 1 1 1 Gcd10p family SPOB_a PF14689.6 EDO07335.1 - 0.08 12.7 0.3 12 5.7 0.2 2.4 2 0 0 2 2 2 0 Sensor_kinase_SpoOB-type, alpha-helical domain DUF2465 PF10239.9 EDO07338.1 - 0.0047 16.2 6.8 0.012 14.9 6.8 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF2465) DUSP PF06337.12 EDO07338.1 - 0.13 12.9 0.8 0.27 11.9 0.2 1.8 1 1 0 1 1 1 0 DUSP domain PMM PF03332.13 EDO07339.1 - 2.4e-99 331.6 0.9 2.8e-99 331.4 0.9 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 EDO07339.1 - 3.8e-13 49.8 0.2 1.4e-12 47.9 0.2 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EDO07339.1 - 3.5e-05 23.5 0.0 0.00099 18.7 0.0 2.1 2 0 0 2 2 2 1 Sucrose-6F-phosphate phosphohydrolase HAD_2 PF13419.6 EDO07339.1 - 0.00041 20.5 0.6 0.0024 18.0 0.5 2.5 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDO07339.1 - 0.098 12.9 0.1 0.28 11.4 0.1 1.5 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF3958 PF13125.6 EDO07339.1 - 0.11 12.8 0.0 1.7 8.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3958) RAP-1 PF03085.15 EDO07340.1 - 6.9e-98 327.1 6.5 6.9e-98 327.1 6.5 1.9 2 0 0 2 2 2 1 Rhoptry-associated protein 1 (RAP-1) REF PF05755.12 EDO07340.1 - 0.0094 15.8 1.8 0.84 9.4 0.4 2.7 1 1 1 2 2 2 2 Rubber elongation factor protein (REF) DUF4132 PF13569.6 EDO07340.1 - 0.054 13.3 3.6 3.2 7.5 0.5 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4132) CAP18_C PF12153.8 EDO07340.1 - 1.5 8.7 4.2 56 3.7 0.0 3.9 4 0 0 4 4 4 0 LPS binding domain of CAP18 (C terminal) DUF5105 PF17118.5 EDO07340.1 - 1.7 8.4 10.7 0.044 13.6 1.9 2.7 3 1 0 3 3 3 0 Domain of unknown function (DUF5105) RAP-1 PF03085.15 EDO07341.1 - 6.9e-98 327.1 6.5 6.9e-98 327.1 6.5 1.9 2 0 0 2 2 2 1 Rhoptry-associated protein 1 (RAP-1) REF PF05755.12 EDO07341.1 - 0.0094 15.8 1.8 0.84 9.4 0.4 2.7 1 1 1 2 2 2 2 Rubber elongation factor protein (REF) DUF4132 PF13569.6 EDO07341.1 - 0.054 13.3 3.6 3.2 7.5 0.5 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4132) CAP18_C PF12153.8 EDO07341.1 - 1.5 8.7 4.2 56 3.7 0.0 3.9 4 0 0 4 4 4 0 LPS binding domain of CAP18 (C terminal) DUF5105 PF17118.5 EDO07341.1 - 1.7 8.4 10.7 0.044 13.6 1.9 2.7 3 1 0 3 3 3 0 Domain of unknown function (DUF5105) HEAT_2 PF13646.6 EDO07342.1 - 7.6e-21 74.3 4.6 1.5e-14 54.1 0.6 2.5 2 0 0 2 2 2 2 HEAT repeats HEAT_PBS PF03130.16 EDO07342.1 - 1.5e-17 62.4 8.5 0.0031 18.0 0.0 6.3 6 0 0 6 6 6 4 PBS lyase HEAT-like repeat HEAT PF02985.22 EDO07342.1 - 3.6e-07 29.9 1.7 0.11 12.8 0.0 4.8 4 0 0 4 4 4 1 HEAT repeat HEAT_EZ PF13513.6 EDO07342.1 - 0.0017 18.8 0.6 2.1 8.9 0.0 3.4 3 0 0 3 3 3 2 HEAT-like repeat Arm PF00514.23 EDO07342.1 - 0.018 15.1 0.5 0.28 11.3 0.0 2.6 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Stress-antifung PF01657.17 EDO07342.1 - 0.12 13.1 0.6 0.84 10.3 0.0 2.5 2 0 0 2 2 2 0 Salt stress response/antifungal DnaJ_C PF01556.18 EDO07343.1 - 2.8e-37 128.1 0.1 4.1e-37 127.5 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EDO07343.1 - 5.9e-25 87.2 0.2 1.1e-24 86.3 0.2 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EDO07343.1 - 4.6e-14 52.5 15.1 8.7e-14 51.6 15.1 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EDO07343.1 - 0.0087 16.0 7.7 0.069 13.1 2.4 2.5 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein DUF1258 PF06869.12 EDO07343.1 - 2.9 7.3 6.9 0.68 9.4 3.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1258) HypA PF01155.19 EDO07343.1 - 5.6 7.0 8.3 10 6.2 3.7 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA eIF2A PF08662.11 EDO07344.1 - 2.8e-58 197.0 0.0 2.3e-57 194.0 0.0 2.1 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A FHA PF00498.26 EDO07345.1 - 0.00025 21.3 0.0 0.0007 19.9 0.0 1.9 1 0 0 1 1 1 1 FHA domain Cmyb_C PF09316.10 EDO07345.1 - 0.022 14.4 0.1 0.44 10.2 0.0 2.2 2 0 0 2 2 2 0 C-myb, C-terminal RPN1_RPN2_N PF17781.1 EDO07346.1 - 5.8e-52 177.0 3.4 8.8e-52 176.4 3.4 1.3 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 EDO07346.1 - 1.8e-23 82.3 0.0 3.3e-23 81.5 0.0 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 EDO07346.1 - 5e-12 45.6 22.7 0.0017 18.7 0.1 8.3 8 0 0 8 8 8 4 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EDO07346.1 - 0.017 15.5 0.2 2.8 8.4 0.0 3.1 2 0 0 2 2 2 0 HEAT repeats TPR_5 PF12688.7 EDO07346.1 - 0.79 10.0 4.2 8.8 6.6 0.5 3.2 3 0 0 3 3 3 0 Tetratrico peptide repeat L1R_F9L PF02442.17 EDO07347.1 - 0.077 12.8 0.6 0.38 10.6 0.1 2.3 2 0 0 2 2 2 0 Lipid membrane protein of large eukaryotic DNA viruses AAA PF00004.29 EDO07348.1 - 6.1e-42 143.2 0.0 2.4e-41 141.3 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO07348.1 - 7.9e-11 41.6 0.0 1.7e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EDO07348.1 - 7.1e-06 26.3 0.2 0.0098 16.2 0.0 2.7 2 1 1 3 3 2 2 AAA domain AAA_5 PF07728.14 EDO07348.1 - 7.6e-06 26.0 0.0 2.8e-05 24.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDO07348.1 - 0.00018 21.9 0.2 0.0058 17.0 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 EDO07348.1 - 0.00023 21.3 0.0 0.00043 20.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EDO07348.1 - 0.00088 19.1 0.0 0.0021 17.8 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 EDO07348.1 - 0.0045 16.5 0.0 0.016 14.7 0.0 1.8 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_18 PF13238.6 EDO07348.1 - 0.011 16.2 0.0 0.024 15.2 0.0 1.6 2 0 0 2 2 1 0 AAA domain AAA_28 PF13521.6 EDO07348.1 - 0.013 15.8 0.0 0.019 15.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EDO07348.1 - 0.015 15.0 0.0 0.12 12.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 EDO07348.1 - 0.021 14.0 0.0 0.033 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 EDO07348.1 - 0.031 14.5 0.0 0.055 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EDO07348.1 - 0.037 13.8 0.0 0.062 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EDO07348.1 - 0.05 13.0 0.0 0.12 11.7 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 EDO07348.1 - 0.063 12.5 0.0 0.12 11.5 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain ATPase PF06745.13 EDO07348.1 - 0.092 12.1 0.0 1.3 8.3 0.0 2.6 3 0 0 3 3 3 0 KaiC RNA_helicase PF00910.22 EDO07348.1 - 0.095 13.1 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase ATPase_2 PF01637.18 EDO07348.1 - 0.13 12.1 0.0 11 5.9 0.0 2.3 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea Sigma54_activat PF00158.26 EDO07348.1 - 0.16 11.7 0.0 0.56 9.9 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 EDO07348.1 - 0.18 11.6 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Adap_comp_sub PF00928.21 EDO07349.1 - 2.9e-82 276.0 0.1 3.5e-82 275.7 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EDO07349.1 - 2.2e-09 37.4 1.1 4e-09 36.5 1.1 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain VirB8 PF04335.13 EDO07349.1 - 0.034 14.0 0.1 0.054 13.3 0.1 1.2 1 0 0 1 1 1 0 VirB8 protein HILPDA PF15220.6 EDO07349.1 - 0.16 12.1 0.1 19 5.5 0.0 2.4 2 0 0 2 2 2 0 Hypoxia-inducible lipid droplet-associated TPT PF03151.16 EDO07351.1 - 5.8e-64 216.2 19.1 7.6e-63 212.6 19.1 2.0 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EDO07351.1 - 6.3e-07 29.6 22.4 1.3e-06 28.6 7.8 2.7 3 0 0 3 3 3 2 EamA-like transporter family BMF PF15185.6 EDO07351.1 - 0.086 12.6 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Bcl-2-modifying factor, apoptosis Ribosomal_S16 PF00886.19 EDO07352.1 - 6.1e-12 45.4 0.0 1.7e-11 44.0 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein S16 G-patch PF01585.23 EDO07353.1 - 7.5e-10 38.6 4.7 2.1e-09 37.1 4.7 1.7 1 0 0 1 1 1 1 G-patch domain GCFC PF07842.12 EDO07353.1 - 1.5e-09 37.9 1.8 1.5e-09 37.9 1.8 1.9 2 0 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein TIP_N PF12457.8 EDO07353.1 - 2.4e-05 24.6 2.5 6.5e-05 23.2 2.5 1.7 1 0 0 1 1 1 1 Tuftelin interacting protein N terminal G-patch_2 PF12656.7 EDO07353.1 - 0.064 13.3 1.3 0.19 11.9 1.3 1.8 1 0 0 1 1 1 0 G-patch domain Cor1 PF04803.12 EDO07353.1 - 6.7 6.9 10.7 6 7.1 2.2 3.1 3 0 0 3 3 3 0 Cor1/Xlr/Xmr conserved region OAD_gamma PF04277.13 EDO07354.1 - 1.6 9.4 5.9 0.32 11.6 0.6 2.5 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain Spc7 PF08317.11 EDO07355.1 - 0.005 15.8 2.9 0.0096 14.8 2.9 1.4 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF4949 PF16307.5 EDO07355.1 - 0.029 14.5 0.1 0.083 13.0 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4949) ECH_2 PF16113.5 EDO07355.1 - 0.051 13.1 1.5 0.18 11.3 0.0 2.1 1 1 1 2 2 2 0 Enoyl-CoA hydratase/isomerase SlyX PF04102.12 EDO07355.1 - 0.45 11.2 2.0 2 9.1 1.9 2.2 1 1 0 1 1 1 0 SlyX E1-E2_ATPase PF00122.20 EDO07356.1 - 6.8e-55 185.4 6.0 2.4e-54 183.6 6.0 2.0 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EDO07356.1 - 5.3e-34 117.5 1.6 3.4e-33 114.9 0.0 2.4 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase_N PF00690.26 EDO07356.1 - 9.8e-18 63.6 0.0 2e-17 62.6 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 EDO07356.1 - 3.8e-17 63.3 0.1 3.2e-13 50.5 0.0 3.7 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDO07356.1 - 1.8e-12 47.1 0.0 6.2e-12 45.4 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EDO07356.1 - 0.00012 21.9 0.9 0.00036 20.4 0.7 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF4064 PF13273.6 EDO07356.1 - 0.011 16.0 2.6 0.011 16.0 2.6 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) HAD PF12710.7 EDO07356.1 - 0.07 13.5 0.0 0.27 11.6 0.0 2.0 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase ubiquitin PF00240.23 EDO07357.1 - 3.1e-105 344.0 10.1 2.8e-34 116.7 0.3 3.0 3 0 0 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.8 EDO07357.1 - 4.7e-51 170.5 10.7 3e-16 59.0 0.4 3.0 3 0 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EDO07357.1 - 2.6e-20 72.7 3.3 7.2e-05 23.2 0.1 4.5 3 3 0 3 3 3 3 Ubiquitin-like domain TBK1_ULD PF18396.1 EDO07357.1 - 1.2e-12 47.5 1.7 0.015 15.2 0.1 3.2 3 0 0 3 3 3 3 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EDO07357.1 - 7e-12 45.4 0.9 0.044 13.9 0.0 4.0 3 3 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EDO07357.1 - 1.5e-11 44.5 2.9 0.03 14.7 0.1 3.1 3 0 0 3 3 3 3 Ubiquitin-like domain DUF2407 PF10302.9 EDO07357.1 - 3e-09 37.4 0.1 0.39 11.3 0.0 3.2 1 1 0 3 3 3 3 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 EDO07357.1 - 1.6e-07 31.3 0.0 0.19 11.6 0.0 3.1 1 1 2 3 3 3 3 Silencing defective 2 N-terminal ubiquitin domain Ubiquitin_4 PF18036.1 EDO07357.1 - 4.8e-06 26.5 14.1 17 5.5 0.0 6.0 6 0 0 6 6 6 0 Ubiquitin-like domain DUF2870 PF11069.8 EDO07357.1 - 0.00023 21.4 0.0 21 5.6 0.0 3.8 3 3 0 3 3 3 0 Protein of unknown function (DUF2870) Methyltrans_RNA PF04452.14 EDO07357.1 - 0.00049 19.5 0.6 1.2 8.4 0.0 2.8 3 0 0 3 3 3 2 RNA methyltransferase RBD PF02196.15 EDO07357.1 - 0.00082 19.4 0.0 23 5.2 0.0 3.4 3 0 0 3 3 3 0 Raf-like Ras-binding domain UDP-g_GGTase PF06427.11 EDO07357.1 - 0.0019 18.3 2.0 3.5 7.8 0.0 3.2 4 0 0 4 4 3 2 UDP-glucose:Glycoprotein Glucosyltransferase DUF3861 PF12977.7 EDO07357.1 - 0.0021 18.2 0.4 27 5.0 0.0 3.2 3 0 0 3 3 3 0 Domain of Unknown Function with PDB structure (DUF3861) DUF969 PF06149.12 EDO07357.1 - 0.0052 16.2 0.0 14 5.0 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF969) FlgD_ig PF13860.6 EDO07357.1 - 0.02 14.8 2.4 40 4.2 0.1 3.4 3 0 0 3 3 3 0 FlgD Ig-like domain Big_7 PF17957.1 EDO07357.1 - 0.022 15.5 0.0 92 3.9 0.0 3.1 3 0 0 3 3 3 0 Bacterial Ig domain GDYXXLXY PF14345.6 EDO07357.1 - 0.055 13.3 0.1 77 3.1 0.0 3.3 3 0 0 3 3 3 0 GDYXXLXY protein CorA PF01544.18 EDO07357.1 - 0.063 12.6 0.1 52 3.0 0.0 3.0 3 0 0 3 3 3 0 CorA-like Mg2+ transporter protein ORF11CD3 PF10549.9 EDO07357.1 - 0.067 13.3 0.0 63 3.8 0.0 3.6 3 0 0 3 3 3 0 ORF11CD3 domain Phage_sheath_1N PF17481.2 EDO07357.1 - 0.068 13.7 1.6 19 5.8 0.3 3.0 1 1 1 2 2 2 0 Phage tail sheath protein beta-sandwich domain TraK PF06586.11 EDO07357.1 - 0.073 12.8 0.1 61 3.2 0.0 3.1 3 0 0 3 3 3 0 TraK protein ProRS-C_2 PF09181.10 EDO07357.1 - 0.091 12.9 1.1 91 3.3 0.0 3.1 3 0 0 3 3 3 0 Prolyl-tRNA synthetase, C-terminal DMA PF03474.14 EDO07357.1 - 0.17 11.5 1.7 41 3.9 0.0 3.3 3 0 0 3 3 3 0 DMRTA motif PI3K_p85B PF02192.16 EDO07357.1 - 1.4 8.7 3.4 1.1e+02 2.6 0.1 3.2 3 0 0 3 3 3 0 PI3-kinase family, p85-binding domain MCM PF00493.23 EDO07358.1 - 1.4e-94 315.4 0.4 1.4e-94 315.4 0.4 1.6 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 EDO07358.1 - 1.9e-28 98.8 0.3 3.3e-28 98.1 0.3 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EDO07358.1 - 2.2e-24 85.7 3.0 4.8e-24 84.6 3.0 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EDO07358.1 - 2.3e-07 30.4 0.0 2.3e-06 27.1 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDO07358.1 - 0.0095 15.9 0.0 0.042 13.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EDO07358.1 - 0.011 15.5 0.0 0.034 14.0 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) zf-Di19 PF05605.12 EDO07358.1 - 0.019 15.3 0.6 0.092 13.1 0.1 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Sigma54_activat PF00158.26 EDO07358.1 - 0.02 14.6 0.0 0.066 12.9 0.0 1.9 1 0 0 1 1 1 0 Sigma-54 interaction domain MCM_N PF14551.6 EDO07358.1 - 0.043 14.4 4.8 0.41 11.3 1.9 2.9 2 1 1 3 3 3 0 MCM N-terminal domain Amino_oxidase PF01593.24 EDO07359.1 - 5.2e-49 167.8 0.0 3.3e-35 122.2 0.0 2.3 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EDO07359.1 - 3.2e-12 46.5 0.1 1e-11 44.9 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EDO07359.1 - 3.5e-06 26.4 0.1 8.4e-06 25.2 0.1 1.6 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 EDO07359.1 - 4.4e-05 22.9 0.0 8e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EDO07359.1 - 0.00014 21.6 3.1 0.00025 20.8 3.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EDO07359.1 - 0.00014 21.3 0.8 0.00031 20.2 0.8 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EDO07359.1 - 0.00018 20.7 2.3 0.00026 20.2 2.3 1.2 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 EDO07359.1 - 0.00033 19.8 0.4 0.00063 18.9 0.4 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EDO07359.1 - 0.00091 18.6 1.5 0.0016 17.8 1.5 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EDO07359.1 - 0.0011 19.5 0.4 0.0034 17.9 0.4 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EDO07359.1 - 0.0028 17.0 1.0 0.0055 16.0 1.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain zf-HC5HC2H PF13771.6 EDO07359.1 - 0.0049 17.1 0.4 0.013 15.7 0.4 1.6 1 0 0 1 1 1 1 PHD-like zinc-binding domain HI0933_like PF03486.14 EDO07359.1 - 0.027 13.2 1.0 0.045 12.5 1.0 1.3 1 0 0 1 1 1 0 HI0933-like protein zf-4CXXC_R1 PF10497.9 EDO07359.1 - 0.064 13.5 7.6 0.19 12.0 7.6 1.8 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 Pyr_redox_3 PF13738.6 EDO07359.1 - 0.081 12.2 0.0 0.21 10.8 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EDO07359.1 - 0.084 11.9 0.6 0.16 11.0 0.6 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein FANCL_C PF11793.8 EDO07359.1 - 1.7 8.9 5.4 4.3 7.6 5.4 1.7 1 0 0 1 1 1 0 FANCL C-terminal domain zf-RING_2 PF13639.6 EDO07359.1 - 7.3 7.0 10.0 17 5.8 10.0 1.7 1 0 0 1 1 1 0 Ring finger domain DnaJ PF00226.31 EDO07360.1 - 1.8e-27 95.3 0.6 1.8e-27 95.3 0.6 2.0 3 0 0 3 3 3 1 DnaJ domain RPT PF13446.6 EDO07360.1 - 0.0031 17.4 0.0 0.0069 16.3 0.0 1.6 1 1 0 1 1 1 1 A repeated domain in UCH-protein MPM1 PF17234.2 EDO07360.1 - 0.085 13.1 1.9 0.097 12.9 1.0 1.5 1 1 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 PDEase_I PF00233.19 EDO07361.1 - 2.8e-62 210.5 0.1 5.2e-62 209.7 0.1 1.4 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Ribosomal_S18 PF01084.20 EDO07362.1 - 1.2e-15 57.5 0.3 1.2e-15 57.5 0.3 2.7 3 0 0 3 3 3 1 Ribosomal protein S18 VASt PF16016.5 EDO07363.1 - 1.5e-12 48.2 0.1 6.8e-12 46.1 0.1 2.1 2 0 0 2 2 2 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EDO07363.1 - 3e-09 36.7 0.0 8.2e-09 35.4 0.0 1.7 1 0 0 1 1 1 1 GRAM domain PH_TFIIH PF08567.11 EDO07363.1 - 0.069 13.5 0.0 0.22 11.9 0.0 1.8 1 0 0 1 1 1 0 TFIIH p62 subunit, N-terminal domain Methyltransf_15 PF09445.10 EDO07364.1 - 2.8e-18 66.0 0.2 5.5e-18 65.1 0.2 1.5 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase RNA_GG_bind PF10258.9 EDO07364.1 - 2e-09 37.4 0.0 3.8e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 PHAX RNA-binding domain Methyltransf_23 PF13489.6 EDO07364.1 - 0.019 14.8 0.0 0.04 13.8 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 EDO07364.1 - 0.054 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltr_RsmB-F PF01189.17 EDO07364.1 - 0.056 13.1 0.0 0.092 12.4 0.0 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F ER PF01133.17 EDO07364.1 - 0.12 12.4 2.6 0.46 10.5 0.7 2.4 2 0 0 2 2 2 0 Enhancer of rudimentary Methyltransf_12 PF08242.12 EDO07364.1 - 1.3 9.8 3.2 11 6.8 0.1 3.1 3 0 0 3 3 3 0 Methyltransferase domain Adap_comp_sub PF00928.21 EDO07365.1 - 2.5e-35 122.2 1.3 9.9e-35 120.2 1.3 1.8 1 1 0 1 1 1 1 Adaptor complexes medium subunit family GDPD PF03009.17 EDO07366.1 - 7.5e-17 61.9 0.0 4.9e-13 49.4 0.0 2.2 2 0 0 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family Dynamin_N PF00350.23 EDO07367.1 - 1.1e-12 48.4 0.0 4e-12 46.5 0.0 2.0 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EDO07367.1 - 0.038 14.1 0.0 0.19 11.8 0.0 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase adh_short PF00106.25 EDO07368.1 - 1.3e-23 83.5 0.0 7e-23 81.1 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDO07368.1 - 4.5e-09 36.2 0.0 6.1e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 EDO07368.1 - 5e-05 22.8 0.0 7.2e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) KR PF08659.10 EDO07368.1 - 0.2 11.5 0.0 0.49 10.3 0.0 1.8 1 1 0 1 1 1 0 KR domain DUF4822 PF16103.5 EDO07369.1 - 0.045 14.0 2.0 0.06 13.6 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4822) Nrap_D4 PF17405.2 EDO07370.1 - 6.3e-35 120.5 0.0 1.3e-34 119.4 0.0 1.4 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap PF03813.14 EDO07370.1 - 4.8e-28 98.1 1.8 1.7e-27 96.3 1.1 2.2 2 0 0 2 2 2 1 Nrap protein domain 1 Nrap_D2 PF17403.2 EDO07370.1 - 9.9e-28 96.8 0.3 3.7e-27 95.0 0.1 2.0 2 0 0 2 2 2 1 Nrap protein PAP/OAS-like domain Nrap_D3 PF17404.2 EDO07370.1 - 3.6e-27 95.4 0.0 7e-27 94.5 0.0 1.5 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D5 PF17406.2 EDO07370.1 - 4.3e-15 55.8 0.1 7.7e-14 51.8 0.1 2.8 3 0 0 3 3 3 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D6 PF17407.2 EDO07370.1 - 3e-08 33.9 0.2 7.8e-08 32.6 0.2 1.7 1 0 0 1 1 1 1 Nrap protein domain 6 zf-RING_2 PF13639.6 EDO07372.1 - 5e-10 39.6 10.9 5e-10 39.6 10.9 2.0 2 0 0 2 2 1 1 Ring finger domain zf-rbx1 PF12678.7 EDO07372.1 - 4.1e-08 33.4 10.5 1.4e-07 31.7 10.5 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EDO07372.1 - 1.5e-06 27.9 10.6 3.2e-06 26.9 10.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDO07372.1 - 2.1e-06 27.5 6.0 5.1e-06 26.3 6.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDO07372.1 - 4.1e-06 26.6 9.6 8.3e-06 25.6 9.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDO07372.1 - 0.00019 21.4 7.8 0.00043 20.2 7.8 1.7 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EDO07372.1 - 0.0016 18.3 9.2 0.0035 17.2 9.2 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EDO07372.1 - 0.002 18.1 4.8 0.0046 17.0 4.8 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 EDO07372.1 - 0.003 17.5 9.5 0.003 17.5 9.5 2.2 2 0 0 2 2 2 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EDO07372.1 - 0.019 14.6 6.0 0.049 13.3 6.0 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 EDO07372.1 - 0.12 12.2 11.6 0.017 14.8 7.4 1.9 2 0 0 2 2 2 0 RING-like zinc finger zf-HC5HC2H PF13771.6 EDO07372.1 - 0.24 11.7 3.9 0.63 10.3 3.9 1.7 1 0 0 1 1 1 0 PHD-like zinc-binding domain FANCL_C PF11793.8 EDO07372.1 - 0.36 11.1 8.0 2.2 8.5 8.0 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.6 EDO07372.1 - 0.57 10.4 8.2 1.2 9.3 8.2 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Rad50_zn_hook PF04423.14 EDO07372.1 - 0.77 9.7 5.1 15 5.5 0.1 3.2 2 0 0 2 2 2 0 Rad50 zinc hook motif Endonuclease_7 PF02945.15 EDO07372.1 - 8.6 6.4 8.1 3.4 7.7 0.4 2.5 1 1 1 2 2 2 0 Recombination endonuclease VII Ribosomal_L1 PF00687.21 EDO07373.1 - 4.3e-17 62.5 0.1 1.5e-16 60.7 0.0 1.8 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family Peptidase_M3_N PF08439.10 EDO07373.1 - 0.21 11.9 0.2 4.9 7.5 0.1 2.5 2 0 0 2 2 2 0 Oligopeptidase F Ribosomal_S25 PF03297.15 EDO07374.1 - 1.8e-34 118.0 8.6 2.1e-34 117.7 8.6 1.0 1 0 0 1 1 1 1 S25 ribosomal protein Rrf2 PF02082.20 EDO07374.1 - 0.011 16.1 0.1 0.02 15.3 0.1 1.4 1 0 0 1 1 1 0 Transcriptional regulator GntR PF00392.21 EDO07374.1 - 0.018 14.7 0.0 0.037 13.7 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family DUF1667 PF07892.11 EDO07374.1 - 0.035 14.1 2.1 2.5 8.2 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1667) DUF5527 PF17665.1 EDO07375.1 - 1.3 8.6 5.2 0.34 10.5 0.2 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5527) CRAL_TRIO PF00650.20 EDO07376.1 - 0.019 14.7 0.4 0.1 12.3 0.0 2.4 2 0 0 2 2 2 0 CRAL/TRIO domain E7 PF00527.18 EDO07376.1 - 0.031 14.5 2.2 0.042 14.0 0.1 2.3 2 0 0 2 2 2 0 E7 protein, Early protein Pkinase PF00069.25 EDO07377.1 - 5.7e-63 212.7 0.0 7.2e-63 212.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO07377.1 - 1.8e-30 106.1 1.2 3.2e-29 102.0 1.2 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EDO07377.1 - 0.0013 18.3 0.1 0.0022 17.6 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 EDO07377.1 - 0.0019 17.1 0.0 0.0029 16.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EDO07377.1 - 0.0019 17.2 0.0 0.0026 16.7 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EDO07377.1 - 0.0053 16.1 0.2 0.013 14.9 0.2 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDO07377.1 - 0.063 13.2 0.0 0.21 11.5 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF1854 PF08909.11 EDO07377.1 - 0.081 12.8 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1854) Kinase-like PF14531.6 EDO07377.1 - 0.11 11.8 0.0 0.22 10.8 0.0 1.5 1 1 0 1 1 1 0 Kinase-like SPRY PF00622.28 EDO07379.1 - 4.8e-14 52.5 0.8 8.4e-14 51.7 0.8 1.4 1 0 0 1 1 1 1 SPRY domain CLTH PF10607.9 EDO07379.1 - 6e-11 42.4 0.7 9.3e-11 41.8 0.7 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-AD PF07776.15 EDO07380.1 - 0.018 15.3 0.7 1 9.7 0.1 2.2 1 1 1 2 2 2 0 Zinc-finger associated domain (zf-AD) Ssl1 PF04056.14 EDO07380.1 - 0.051 13.4 0.0 0.055 13.3 0.0 1.1 1 0 0 1 1 1 0 Ssl1-like zf-C2HE PF16278.5 EDO07380.1 - 0.91 10.0 5.3 0.64 10.5 2.2 2.5 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Ank_2 PF12796.7 EDO07381.1 - 1.4e-26 92.9 11.8 9.2e-15 55.0 0.9 2.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Bromodomain PF00439.25 EDO07381.1 - 8.6e-20 70.6 0.1 1.9e-19 69.5 0.1 1.6 1 0 0 1 1 1 1 Bromodomain Ank_4 PF13637.6 EDO07381.1 - 1.4e-17 63.8 4.2 6.1e-08 33.1 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDO07381.1 - 4.4e-13 48.1 0.5 0.0025 18.2 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EDO07381.1 - 7.3e-10 38.9 2.9 1.7e-06 28.1 0.2 3.2 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EDO07381.1 - 9.5e-09 35.3 1.3 0.0018 18.6 0.1 3.6 3 0 0 3 3 3 3 Ankyrin repeat RAP-1 PF03085.15 EDO07382.1 - 4e-93 311.6 11.2 5.2e-93 311.2 11.2 1.1 1 0 0 1 1 1 1 Rhoptry-associated protein 1 (RAP-1) DUF3511 PF12023.8 EDO07382.1 - 0.056 13.3 1.2 0.15 11.9 1.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3511) FlpD PF02662.16 EDO07382.1 - 0.12 12.4 0.3 15 5.7 0.0 2.5 2 0 0 2 2 2 0 Methyl-viologen-reducing hydrogenase, delta subunit PP28 PF10252.9 EDO07383.1 - 5.9e-13 49.1 20.3 2.9e-12 46.8 20.3 2.1 1 1 0 1 1 1 1 Casein kinase substrate phosphoprotein PP28 AMA-1 PF02430.15 EDO07383.1 - 0.0047 15.9 1.3 0.0054 15.7 1.3 1.0 1 0 0 1 1 1 1 Apical membrane antigen 1 DUF382 PF04037.13 EDO07383.1 - 0.2 11.8 2.4 0.33 11.1 2.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF382) SpoIIIAH PF12685.7 EDO07383.1 - 2.2 8.0 12.1 2.8 7.7 12.1 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein Herpes_DNAp_acc PF04929.12 EDO07383.1 - 7.2 5.5 10.0 9 5.2 10.0 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor CDC45 PF02724.14 EDO07383.1 - 8.3 4.6 15.3 9.7 4.3 15.3 1.1 1 0 0 1 1 1 0 CDC45-like protein SNARE PF05739.19 EDO07384.1 - 0.016 15.2 1.8 0.029 14.4 0.9 1.9 2 0 0 2 2 2 0 SNARE domain PilJ PF13675.6 EDO07384.1 - 0.041 13.9 0.5 0.15 12.1 0.0 2.1 2 1 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term NPV_P10 PF05531.12 EDO07384.1 - 0.17 12.4 3.2 0.51 10.8 0.8 2.5 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein XhlA PF10779.9 EDO07384.1 - 0.4 10.9 5.2 7.3 6.9 0.0 2.8 2 1 0 2 2 2 0 Haemolysin XhlA Allexi_40kDa PF05549.11 EDO07384.1 - 0.8 9.2 10.1 0.34 10.4 1.7 2.1 1 1 0 2 2 2 0 Allexivirus 40kDa protein Sec8_exocyst PF04048.14 EDO07384.1 - 4.7 7.1 10.4 6.3 6.7 0.2 3.3 2 2 1 3 3 3 0 Sec8 exocyst complex component specific domain Helicase_C PF00271.31 EDO07385.1 - 9.9e-09 35.5 0.1 6.6e-08 32.9 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HA2 PF04408.23 EDO07385.1 - 5.8e-06 26.5 0.0 1.6e-05 25.1 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) AAA_22 PF13401.6 EDO07385.1 - 0.00038 20.7 0.0 0.00095 19.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 EDO07385.1 - 0.0013 18.5 0.0 0.13 12.0 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase ATPase PF06745.13 EDO07385.1 - 0.0054 16.1 0.5 0.015 14.6 0.0 1.9 2 0 0 2 2 2 1 KaiC DUF2075 PF09848.9 EDO07385.1 - 0.0059 15.9 0.0 0.01 15.1 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 EDO07385.1 - 0.085 12.3 0.0 0.22 10.9 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein zf-RING_2 PF13639.6 EDO07386.1 - 4.8e-13 49.2 5.0 1e-12 48.2 5.0 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDO07386.1 - 3.8e-10 39.4 4.9 9e-10 38.2 4.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EDO07386.1 - 2.7e-09 36.6 2.0 2.7e-09 36.6 2.0 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 EDO07386.1 - 3.7e-09 36.3 4.4 8.5e-09 35.1 4.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EDO07386.1 - 1.1e-08 35.2 6.0 4.7e-08 33.2 6.0 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EDO07386.1 - 9e-06 25.6 3.2 9e-06 25.6 3.2 1.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EDO07386.1 - 2.4e-05 24.1 2.5 4.3e-05 23.3 2.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDO07386.1 - 0.00065 19.7 2.9 0.0019 18.2 2.9 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EDO07386.1 - 0.0095 16.0 4.3 0.064 13.3 4.3 2.2 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EDO07386.1 - 0.029 14.0 3.0 0.077 12.6 3.0 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 EDO07386.1 - 0.045 13.6 2.3 0.1 12.5 2.4 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 FANCL_C PF11793.8 EDO07386.1 - 0.046 13.9 4.3 0.15 12.3 4.3 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain zinc_ribbon_16 PF17034.5 EDO07386.1 - 0.048 13.9 2.0 0.061 13.5 1.0 1.6 1 1 0 1 1 1 0 Zinc-ribbon like family zf-RING-like PF08746.11 EDO07386.1 - 0.13 12.6 2.3 0.28 11.5 2.3 1.5 1 0 0 1 1 1 0 RING-like domain zf-Nse PF11789.8 EDO07386.1 - 0.15 11.9 1.5 0.28 11.0 1.5 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.6 EDO07386.1 - 5.7 7.2 6.8 4.3 7.6 3.9 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING PTPA PF03095.15 EDO07387.1 - 6.4e-70 236.0 0.1 8e-70 235.7 0.1 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein His_Phos_2 PF00328.22 EDO07388.1 - 8.4e-52 176.8 0.0 5.2e-51 174.2 0.0 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 EDO07388.1 - 1e-32 112.1 0.1 3.1e-32 110.6 0.1 1.9 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 EDO07388.1 - 0.00049 19.7 0.0 0.0013 18.3 0.0 1.7 1 0 0 1 1 1 1 RimK-like ATP-grasp domain DUF4201 PF13870.6 EDO07388.1 - 0.44 10.3 8.5 0.16 11.7 3.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Asp PF00026.23 EDO07389.1 - 3.9e-45 154.6 0.0 1.1e-44 153.2 0.0 1.7 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDO07389.1 - 1.4e-05 25.4 0.0 7e-05 23.1 0.0 2.1 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EDO07389.1 - 0.049 13.4 0.0 0.14 11.9 0.0 1.7 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal VPS28 PF03997.12 EDO07390.1 - 6.1e-50 169.5 0.9 7.2e-50 169.3 0.9 1.1 1 0 0 1 1 1 1 VPS28 protein GvpG PF05120.12 EDO07390.1 - 0.054 13.5 0.7 0.13 12.2 0.7 1.7 1 0 0 1 1 1 0 Gas vesicle protein G ELFV_dehydrog PF00208.21 EDO07392.1 - 1.8e-78 263.7 0.1 2.2e-78 263.4 0.1 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 EDO07392.1 - 2.1e-49 166.7 0.0 1.3e-48 164.2 0.0 2.1 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain NAD_binding_7 PF13241.6 EDO07392.1 - 0.01 16.3 0.0 0.032 14.7 0.0 1.9 1 1 0 1 1 1 0 Putative NAD(P)-binding FAST_1 PF06743.15 EDO07393.1 - 0.0024 17.8 2.1 0.17 11.8 0.0 4.1 4 0 0 4 4 4 1 FAST kinase-like protein, subdomain 1 Retrotran_gag_2 PF14223.6 EDO07393.1 - 0.014 15.0 0.0 0.099 12.3 0.0 2.4 3 0 0 3 3 3 0 gag-polypeptide of LTR copia-type Adaptin_N PF01602.20 EDO07394.1 - 3.5e-55 187.6 2.7 3.5e-55 187.6 2.7 1.4 2 0 0 2 2 2 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 EDO07394.1 - 1.2e-22 80.3 0.0 7e-22 77.8 0.0 2.3 1 1 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 EDO07394.1 - 2.1e-17 63.4 1.4 3.9e-17 62.5 1.4 1.5 1 0 0 1 1 1 1 Coatomer beta C-terminal region Cnd1 PF12717.7 EDO07394.1 - 9.4e-05 22.5 0.4 0.011 15.8 0.0 3.1 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 EDO07394.1 - 0.00016 21.9 0.0 0.017 15.3 0.0 3.3 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 EDO07394.1 - 0.00072 19.9 0.0 0.077 13.4 0.0 2.9 2 0 0 2 2 2 1 HEAT repeats Coatomer_g_Cpla PF16381.5 EDO07394.1 - 0.044 13.9 0.0 8 6.6 0.0 2.6 2 0 0 2 2 2 0 Coatomer subunit gamma-1 C-terminal appendage platform HEAT PF02985.22 EDO07394.1 - 0.15 12.4 4.8 4.3 7.9 0.0 4.9 6 0 0 6 6 6 0 HEAT repeat Ribosomal_L27A PF00828.19 EDO07395.1 - 8.4e-16 58.8 0.0 2.3e-15 57.4 0.0 1.7 2 0 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Diphthamide_syn PF01866.17 EDO07396.1 - 1.7e-36 126.2 0.6 2.7e-36 125.6 0.6 1.2 1 0 0 1 1 1 1 Putative diphthamide synthesis protein COX2 PF00116.20 EDO07397.1 - 1.1e-41 141.5 0.0 1.4e-41 141.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, periplasmic domain Ribosomal_L17 PF01196.19 EDO07398.1 - 1.5e-18 67.5 0.0 2.5e-18 66.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L17 MMR_HSR1 PF01926.23 EDO07399.1 - 1.2e-16 60.8 0.1 1.1e-14 54.4 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDO07399.1 - 5.5e-07 29.3 0.5 2.6e-06 27.0 0.2 2.3 2 1 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EDO07399.1 - 0.0029 17.5 0.0 0.24 11.3 0.0 2.6 1 1 1 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 EDO07399.1 - 0.15 12.4 0.0 0.46 10.8 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Pkinase PF00069.25 EDO07401.1 - 1e-64 218.5 0.0 1.4e-64 218.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO07401.1 - 1.4e-27 96.6 0.0 2e-27 96.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDO07401.1 - 1.2e-05 24.4 1.2 3.7e-05 22.8 1.2 1.8 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EDO07401.1 - 0.00052 19.4 0.0 0.01 15.2 0.0 2.5 1 1 1 2 2 2 1 Kinase-like FeoB_N PF02421.18 EDO07401.1 - 0.048 13.2 0.1 0.085 12.4 0.1 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B ATP-grasp_2 PF08442.10 EDO07402.1 - 5.9e-56 189.2 0.3 1e-55 188.5 0.1 1.5 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 EDO07402.1 - 3e-20 72.6 0.3 4.9e-20 71.9 0.3 1.3 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 EDO07402.1 - 0.00025 20.9 0.1 0.00046 20.0 0.1 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain ATP-grasp_5 PF13549.6 EDO07402.1 - 0.00049 19.6 0.1 0.0052 16.3 0.1 2.3 1 1 0 1 1 1 1 ATP-grasp domain SF-assemblin PF06705.11 EDO07403.1 - 1.1e-08 34.7 15.3 1.4e-08 34.4 15.3 1.1 1 0 0 1 1 1 1 SF-assemblin/beta giardin Baculo_PEP_C PF04513.12 EDO07403.1 - 0.00024 21.2 5.5 0.0054 16.8 4.9 2.6 1 1 2 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1640 PF07798.11 EDO07403.1 - 0.0048 17.0 11.6 0.11 12.5 6.9 2.8 2 1 0 3 3 3 1 Protein of unknown function (DUF1640) HSBP1 PF06825.12 EDO07403.1 - 0.0067 16.3 3.6 0.034 14.0 0.0 3.6 4 1 0 4 4 4 1 Heat shock factor binding protein 1 CLZ PF16526.5 EDO07403.1 - 0.0078 16.5 6.3 0.57 10.6 0.2 2.9 1 1 1 2 2 2 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Apolipoprotein PF01442.18 EDO07403.1 - 0.036 14.0 7.8 0.069 13.0 7.1 1.8 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF885 PF05960.11 EDO07403.1 - 0.12 11.9 1.0 0.16 11.6 1.0 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) DUF1664 PF07889.12 EDO07403.1 - 0.21 11.6 6.8 0.18 11.8 1.1 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Phage_GPO PF05929.11 EDO07403.1 - 0.26 10.9 7.2 0.93 9.1 6.6 2.0 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase CorA PF01544.18 EDO07403.1 - 0.32 10.3 5.6 0.18 11.1 1.1 2.1 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Fib_alpha PF08702.10 EDO07403.1 - 0.33 11.1 10.4 0.23 11.7 4.2 2.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Phasin PF05597.11 EDO07403.1 - 0.34 10.9 11.7 0.3 11.1 7.6 2.4 1 1 2 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF948 PF06103.11 EDO07403.1 - 0.57 10.5 3.2 1.4 9.2 1.6 2.4 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1515 PF07439.11 EDO07403.1 - 0.6 10.2 5.0 1.8 8.6 1.5 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) FlaF PF07309.11 EDO07403.1 - 1.1 9.3 7.2 25 4.9 4.4 2.9 3 1 0 3 3 3 0 Flagellar protein FlaF SlyX PF04102.12 EDO07403.1 - 1.1 10.0 6.3 2.6 8.7 0.3 3.3 1 1 2 3 3 3 0 SlyX WASH_WAHD PF11945.8 EDO07403.1 - 1.1 8.7 8.3 0.072 12.6 0.8 2.1 1 1 1 2 2 2 0 WAHD domain of WASH complex Exonuc_VII_L PF02601.15 EDO07403.1 - 1.5 8.3 8.5 2.4 7.6 8.5 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF16 PF01519.16 EDO07403.1 - 1.8 9.1 12.0 3.7 8.1 7.7 2.7 1 1 1 2 2 2 0 Protein of unknown function DUF16 ApoLp-III PF07464.11 EDO07403.1 - 2.2 8.4 11.2 15 5.7 6.8 2.5 1 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) DUF2205 PF10224.9 EDO07403.1 - 2.3 8.3 7.2 0.64 10.1 0.5 2.9 2 1 1 3 3 2 0 Short coiled-coil protein DUF3782 PF12644.7 EDO07403.1 - 2.9 8.1 6.5 28 5.0 1.4 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3782) LMBR1 PF04791.16 EDO07403.1 - 3.9 6.3 4.6 4.6 6.0 4.6 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein UPF0242 PF06785.11 EDO07403.1 - 4.2 7.4 10.9 21 5.2 7.6 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Ribosomal_L14e PF01929.17 EDO07404.1 - 2e-24 85.9 1.9 2.5e-24 85.6 1.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 EDO07404.1 - 0.00032 20.5 0.3 0.0014 18.5 0.0 2.1 3 0 0 3 3 3 1 KOW motif DUF773 PF05600.12 EDO07405.1 - 8.2e-26 90.8 22.0 3.8e-18 65.5 7.4 2.1 1 1 1 2 2 2 2 CDK5 regulatory subunit-associated protein 3 MIP-T3_C PF17749.1 EDO07405.1 - 0.012 15.6 1.0 0.04 13.9 1.0 1.9 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 C-terminal region DUF1515 PF07439.11 EDO07405.1 - 0.043 13.8 1.2 9 6.4 0.4 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF1515) KH_5 PF13184.6 EDO07405.1 - 0.055 13.6 0.7 3.3 7.9 0.1 3.5 4 0 0 4 4 4 0 NusA-like KH domain DUF4404 PF14357.6 EDO07405.1 - 0.063 13.9 2.1 0.19 12.4 0.8 2.4 2 0 0 2 2 1 0 Domain of unknown function (DUF4404) CC2-LZ PF16516.5 EDO07405.1 - 0.11 12.9 6.1 0.079 13.3 1.4 2.9 3 0 0 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Hydrophobin PF01185.18 EDO07405.1 - 0.11 13.1 0.2 0.35 11.5 0.2 1.8 1 0 0 1 1 1 0 Fungal hydrophobin DUF1664 PF07889.12 EDO07405.1 - 0.17 12.0 3.6 1 9.4 0.6 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) CK2S PF15011.6 EDO07405.1 - 0.27 11.1 5.0 0.36 10.7 2.3 2.5 2 1 0 2 2 2 0 Casein Kinase 2 substrate Sec8_exocyst PF04048.14 EDO07405.1 - 0.45 10.4 6.9 2 8.3 0.3 3.3 3 0 0 3 3 3 0 Sec8 exocyst complex component specific domain Prefoldin PF02996.17 EDO07405.1 - 0.53 10.2 14.7 0.29 11.0 3.1 4.0 4 1 0 4 4 4 0 Prefoldin subunit COG2 PF06148.11 EDO07405.1 - 1.1 9.3 5.6 0.6 10.2 0.8 2.9 3 1 1 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF948 PF06103.11 EDO07405.1 - 1.2 9.4 6.0 11 6.3 0.4 4.1 5 1 0 5 5 5 0 Bacterial protein of unknown function (DUF948) Snapin_Pallidin PF14712.6 EDO07405.1 - 1.2 9.5 6.2 1.1 9.7 1.2 3.2 3 0 0 3 3 3 0 Snapin/Pallidin KxDL PF10241.9 EDO07405.1 - 2.2 8.6 10.1 0.51 10.6 1.0 3.5 4 0 0 4 4 4 0 Uncharacterized conserved protein DASH_Duo1 PF08651.10 EDO07405.1 - 2.3 8.1 6.6 0.61 9.9 0.7 3.0 3 0 0 3 3 3 0 DASH complex subunit Duo1 ArnB_C PF18677.1 EDO07405.1 - 2.6 8.2 13.5 0.58 10.3 2.5 3.7 4 0 0 4 4 3 0 Archaellum regulatory network B, C-terminal domain DUF745 PF05335.13 EDO07405.1 - 2.7 7.7 7.6 3.2 7.5 2.3 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF745) DUF725 PF05267.12 EDO07405.1 - 3.2 7.8 7.3 4.3 7.3 2.2 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF725) FlaC_arch PF05377.11 EDO07405.1 - 3.3 8.2 7.2 2 8.9 3.1 2.9 3 0 0 3 3 1 0 Flagella accessory protein C (FlaC) APG6_N PF17675.1 EDO07405.1 - 4.5 7.8 9.0 0.41 11.2 1.4 2.9 3 0 0 3 3 3 0 Apg6 coiled-coil region GreA_GreB_N PF03449.15 EDO07405.1 - 7.8 6.7 7.6 32 4.8 0.8 3.6 4 0 0 4 4 3 0 Transcription elongation factor, N-terminal DUF2383 PF09537.10 EDO07406.1 - 0.00055 20.3 6.5 0.038 14.3 0.1 3.9 2 1 1 4 4 4 1 Domain of unknown function (DUF2383) Spc42p PF11544.8 EDO07406.1 - 0.0011 18.9 8.5 0.031 14.3 0.1 3.3 2 1 0 3 3 3 2 Spindle pole body component Spc42p Syntaxin PF00804.25 EDO07406.1 - 0.0039 16.9 13.0 0.013 15.1 11.4 2.5 1 1 0 1 1 1 1 Syntaxin Syntaxin_2 PF14523.6 EDO07406.1 - 0.011 16.1 1.2 0.011 16.1 1.2 2.7 1 1 1 2 2 2 0 Syntaxin-like protein Orn_DAP_Arg_deC PF00278.22 EDO07406.1 - 0.021 15.1 0.1 0.039 14.2 0.1 1.4 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase, C-terminal sheet domain TACC_C PF05010.14 EDO07406.1 - 0.027 14.3 15.2 0.028 14.2 3.2 2.6 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal BT1 PF03092.16 EDO07406.1 - 0.028 12.7 0.3 0.039 12.2 0.3 1.1 1 0 0 1 1 1 0 BT1 family DASH_Hsk3 PF08227.11 EDO07406.1 - 0.045 14.1 0.4 14 6.2 0.0 3.0 2 1 0 2 2 2 0 DASH complex subunit Hsk3 like FISNA PF14484.6 EDO07406.1 - 0.053 13.7 1.3 0.13 12.5 0.2 2.2 2 0 0 2 2 2 0 Fish-specific NACHT associated domain RNase_H2-Ydr279 PF09468.10 EDO07406.1 - 0.074 13.2 2.8 0.16 12.1 2.0 1.9 1 1 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) wHTH domain Retrotrans_gag PF03732.17 EDO07406.1 - 0.14 12.5 9.5 0.21 11.9 1.0 3.2 1 1 2 3 3 3 0 Retrotransposon gag protein DUF16 PF01519.16 EDO07406.1 - 0.14 12.7 11.4 0.23 12.0 2.2 3.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 CLZ PF16526.5 EDO07406.1 - 0.38 11.1 5.7 0.59 10.5 0.0 3.3 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels PI3K_P85_iSH2 PF16454.5 EDO07406.1 - 0.46 10.1 13.6 3.1 7.4 7.2 2.9 1 1 2 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain SlyX PF04102.12 EDO07406.1 - 0.95 10.1 3.6 2.3 8.9 0.4 2.8 3 0 0 3 3 2 0 SlyX UPF0242 PF06785.11 EDO07406.1 - 0.97 9.5 10.9 1.7 8.7 10.5 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ADIP PF11559.8 EDO07406.1 - 1.4 9.0 16.7 0.64 10.1 2.1 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4349 PF14257.6 EDO07406.1 - 1.5 8.2 8.1 0.093 12.2 0.9 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4349) THOC7 PF05615.13 EDO07406.1 - 1.7 8.9 13.4 16 5.7 11.5 2.5 1 1 1 2 2 2 0 Tho complex subunit 7 BRE1 PF08647.11 EDO07406.1 - 2.2 8.4 12.2 2.4 8.3 7.1 2.6 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase RSS_P20 PF11757.8 EDO07406.1 - 2.5 8.6 11.0 0.12 12.8 0.6 2.7 2 2 0 2 2 2 0 Suppressor of RNA silencing P21-like N-terminal domain Plk4_PB2 PF18409.1 EDO07406.1 - 2.6 8.8 8.0 1.8 9.2 2.0 2.5 2 1 0 2 2 2 0 Polo-like Kinase 4 Polo Box 2 Seryl_tRNA_N PF02403.22 EDO07406.1 - 3 8.1 12.0 8.7 6.6 5.4 3.0 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Fib_alpha PF08702.10 EDO07406.1 - 3.5 7.8 17.0 1.5 9.0 8.5 2.8 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Vac_Fusion PF02346.16 EDO07406.1 - 5.5 6.7 6.2 36 4.1 0.1 3.3 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 Nop10p PF04135.12 EDO07407.1 - 2e-23 82.2 0.1 2.2e-23 82.0 0.1 1.0 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family Rtf2 PF04641.12 EDO07408.1 - 1.4e-44 152.5 0.3 2e-44 151.9 0.3 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger zf-NOSIP PF15906.5 EDO07408.1 - 3.1e-05 24.0 0.0 9.2e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 EDO07408.1 - 0.013 15.3 4.9 3.4 7.6 0.0 3.0 2 1 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zinc_ribbon_9 PF14369.6 EDO07408.1 - 0.046 14.0 0.1 0.24 11.7 0.0 2.0 2 0 0 2 2 2 0 zinc-ribbon Hydrolase_4 PF12146.8 EDO07409.1 - 1.9e-23 83.0 0.0 3.4e-22 78.9 0.0 2.5 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDO07409.1 - 1.4e-06 28.2 0.5 8.2e-05 22.4 0.3 2.8 2 1 0 3 3 3 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 EDO07409.1 - 0.00032 20.6 0.0 0.0012 18.8 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EDO07409.1 - 0.001 18.6 0.0 0.12 11.8 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EDO07409.1 - 0.0018 18.9 0.0 0.0033 18.1 0.0 1.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 EDO07409.1 - 0.066 13.0 0.1 6.1 6.6 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase zf-HC5HC2H_2 PF13832.6 EDO07410.1 - 6.8e-19 68.1 27.9 1.8e-12 47.4 6.8 3.8 3 1 0 3 3 3 3 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EDO07410.1 - 4.3e-11 42.9 14.7 5.4e-08 33.0 1.9 4.4 3 1 1 4 4 4 2 PHD-like zinc-binding domain PHD PF00628.29 EDO07410.1 - 2.4e-05 24.1 7.0 2.4e-05 24.1 7.0 4.5 4 1 0 4 4 4 3 PHD-finger C1_1 PF00130.22 EDO07410.1 - 0.0012 18.7 2.6 0.0012 18.7 2.6 4.2 4 0 0 4 4 4 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_2 PF13831.6 EDO07410.1 - 0.0056 16.2 15.4 1.3 8.7 0.2 3.9 2 1 0 2 2 2 2 PHD-finger Sybindin PF04099.12 EDO07411.1 - 1.5e-16 60.6 0.0 1.5e-16 60.6 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EDO07411.1 - 0.035 14.2 0.0 0.048 13.8 0.0 1.2 1 0 0 1 1 1 0 Sedlin, N-terminal conserved region Rnf-Nqr PF02508.14 EDO07411.1 - 0.097 12.7 1.1 0.17 11.9 1.1 1.4 1 1 0 1 1 1 0 Rnf-Nqr subunit, membrane protein MutS_V PF00488.21 EDO07412.1 - 1.7e-15 57.5 0.2 5.1e-15 56.0 0.2 1.8 1 0 0 1 1 1 1 MutS domain V AAA_23 PF13476.6 EDO07412.1 - 1.1e-05 26.0 0.0 2.4e-05 24.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EDO07412.1 - 0.00034 20.3 0.1 0.00084 19.0 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_14 PF13173.6 EDO07412.1 - 0.001 19.1 0.1 0.0071 16.4 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_15 PF13175.6 EDO07412.1 - 0.0015 18.3 0.3 0.0015 18.3 0.3 2.2 2 1 0 2 2 2 1 AAA ATPase domain Sigma54_activ_2 PF14532.6 EDO07412.1 - 0.0049 17.0 0.0 0.017 15.3 0.0 1.9 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_21 PF13304.6 EDO07412.1 - 0.0065 16.3 1.3 0.0077 16.1 0.1 1.7 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_27 PF13514.6 EDO07412.1 - 0.015 14.9 0.0 0.029 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EDO07412.1 - 0.017 14.9 0.1 0.057 13.1 0.1 1.9 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_30 PF13604.6 EDO07412.1 - 0.043 13.5 0.0 0.11 12.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EDO07412.1 - 0.064 13.8 0.4 0.29 11.6 0.0 2.3 2 0 0 2 2 2 0 ABC transporter SMC_N PF02463.19 EDO07412.1 - 0.23 10.8 3.4 0.54 9.6 0.1 2.7 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain DUF4760 PF15956.5 EDO07413.1 - 0.0011 19.2 0.1 0.002 18.3 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4760) HTH_56 PF18662.1 EDO07413.1 - 0.077 13.1 0.0 13 5.9 0.0 2.4 2 0 0 2 2 2 0 Cch helix turn helix domain Ribonuc_red_sm PF00268.21 EDO07414.1 - 6.6e-111 370.2 0.1 7.9e-111 370.0 0.1 1.0 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain GTP_EFTU PF00009.27 EDO07415.1 - 1.2e-53 181.5 0.1 1.8e-53 181.0 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EDO07415.1 - 1.1e-39 135.1 0.6 5.6e-39 132.9 0.2 2.1 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EDO07415.1 - 1.3e-12 48.0 0.0 4.9e-12 46.1 0.0 2.1 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDO07415.1 - 8.5e-05 22.6 0.2 0.0041 17.2 0.2 2.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase FlpD PF02662.16 EDO07415.1 - 0.0057 16.6 0.3 0.028 14.4 0.0 2.1 2 0 0 2 2 2 1 Methyl-viologen-reducing hydrogenase, delta subunit NIF3 PF01784.18 EDO07415.1 - 0.069 12.8 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 NIF3 (NGG1p interacting factor 3) Semialdhyde_dhC PF02774.18 EDO07415.1 - 0.08 13.0 0.7 0.13 12.3 0.2 1.6 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, dimerisation domain GTP_EFTU PF00009.27 EDO07416.1 - 1.2e-53 181.5 0.1 1.8e-53 181.0 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EDO07416.1 - 1.1e-39 135.1 0.6 5.6e-39 132.9 0.2 2.1 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EDO07416.1 - 1.3e-12 48.0 0.0 4.9e-12 46.1 0.0 2.1 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDO07416.1 - 8.5e-05 22.6 0.2 0.0041 17.2 0.2 2.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase FlpD PF02662.16 EDO07416.1 - 0.0057 16.6 0.3 0.028 14.4 0.0 2.1 2 0 0 2 2 2 1 Methyl-viologen-reducing hydrogenase, delta subunit NIF3 PF01784.18 EDO07416.1 - 0.069 12.8 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 NIF3 (NGG1p interacting factor 3) Semialdhyde_dhC PF02774.18 EDO07416.1 - 0.08 13.0 0.7 0.13 12.3 0.2 1.6 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, dimerisation domain tRNA-synt_1c PF00749.21 EDO07417.1 - 1.5e-66 224.5 0.0 1.9e-64 217.5 0.0 2.2 1 1 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain Pkinase PF00069.25 EDO07418.1 - 2.1e-75 253.5 0.0 2.4e-75 253.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO07418.1 - 9.8e-34 116.8 0.0 1.2e-33 116.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDO07418.1 - 0.00019 20.5 0.1 0.00047 19.2 0.1 1.6 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EDO07418.1 - 0.00071 19.0 0.1 0.0022 17.4 0.0 1.8 2 1 0 2 2 2 1 Kinase-like RIO1 PF01163.22 EDO07418.1 - 0.0023 17.6 0.0 0.0044 16.6 0.0 1.4 1 1 0 1 1 1 1 RIO1 family APH PF01636.23 EDO07418.1 - 0.019 14.9 0.0 0.046 13.6 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EDO07418.1 - 0.1 11.9 0.2 0.27 10.5 0.2 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DnaJ PF00226.31 EDO07420.1 - 1.6e-20 73.0 5.4 2.7e-20 72.3 5.4 1.4 1 0 0 1 1 1 1 DnaJ domain GAS PF13851.6 EDO07420.1 - 0.032 13.6 0.7 3.4 7.0 0.0 2.4 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding RCC1 PF00415.18 EDO07421.1 - 3.8e-27 94.7 11.2 3.3e-09 37.2 0.1 7.5 7 2 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EDO07421.1 - 8.3e-15 54.1 9.9 4.5e-05 23.1 0.1 5.5 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat Pkinase PF00069.25 EDO07422.1 - 6.3e-17 61.8 0.0 1.5e-08 34.3 0.0 3.6 3 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO07422.1 - 9.8e-05 21.8 0.2 0.07 12.4 0.2 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase UQ_con PF00179.26 EDO07423.1 - 9.8e-49 164.6 0.0 1.2e-48 164.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDO07423.1 - 2.2e-05 24.1 0.0 3.1e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EDO07423.1 - 0.0013 19.1 0.3 0.0023 18.2 0.3 1.5 1 1 0 1 1 1 1 RWD domain UBA_4 PF14555.6 EDO07423.1 - 0.0015 18.3 0.0 0.003 17.4 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain UEV PF05743.13 EDO07423.1 - 0.03 14.2 0.0 0.053 13.4 0.0 1.4 1 0 0 1 1 1 0 UEV domain Tim17 PF02466.19 EDO07424.1 - 1.8e-10 41.1 6.7 2.5e-10 40.7 6.7 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family UEV PF05743.13 EDO07425.1 - 1.6e-15 57.0 0.0 3e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 UEV domain UQ_con PF00179.26 EDO07425.1 - 0.00034 20.3 0.1 0.00062 19.4 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Vps23_core PF09454.10 EDO07425.1 - 0.0053 16.7 0.3 0.013 15.4 0.3 1.7 1 0 0 1 1 1 1 Vps23 core domain DUF3142 PF11340.8 EDO07425.1 - 0.17 11.7 0.0 0.35 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3142) Glutaredoxin PF00462.24 EDO07426.1 - 3.5e-05 23.9 0.0 6.6e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin Sas10 PF09368.10 EDO07429.1 - 3.9e-19 68.9 6.3 3.9e-19 68.9 6.3 3.1 4 0 0 4 4 4 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 EDO07429.1 - 4.6e-13 49.6 3.7 4.6e-13 49.6 3.7 3.1 2 1 0 2 2 2 1 Sas10/Utp3/C1D family Snapin_Pallidin PF14712.6 EDO07429.1 - 0.29 11.6 10.2 5.1 7.6 0.2 4.2 4 0 0 4 4 4 0 Snapin/Pallidin Filamin PF00630.19 EDO07430.1 - 1.3e-14 54.8 0.2 4.5e-12 46.7 0.0 3.9 4 0 0 4 4 4 1 Filamin/ABP280 repeat Streptin-Immun PF11083.8 EDO07430.1 - 0.27 11.7 1.6 0.69 10.4 0.5 2.3 1 1 1 2 2 2 0 Lantibiotic streptin immunity protein IncD PF17628.2 EDO07432.1 - 0.075 12.8 0.2 0.17 11.7 0.2 1.6 1 1 0 1 1 1 0 Inclusion membrane protein D ACBP PF00887.19 EDO07434.1 - 1.1e-17 64.0 0.0 2.4e-17 62.9 0.0 1.5 2 0 0 2 2 2 1 Acyl CoA binding protein Ank_5 PF13857.6 EDO07434.1 - 1.1e-14 54.3 2.4 2.7e-10 40.3 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EDO07434.1 - 1.4e-14 54.3 0.1 1.6e-11 44.5 0.0 1.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDO07434.1 - 4.2e-14 52.9 0.0 9.4e-14 51.8 0.0 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDO07434.1 - 4.7e-12 45.0 0.1 0.00014 22.0 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EDO07434.1 - 5.1e-12 45.7 1.1 4.1e-06 27.0 0.1 2.8 3 0 0 3 3 3 2 Ankyrin repeat DUF2387 PF09526.10 EDO07435.1 - 0.12 12.5 0.1 0.24 11.6 0.1 1.5 1 0 0 1 1 1 0 Probable metal-binding protein (DUF2387) SET PF00856.28 EDO07436.1 - 8.5e-08 32.8 0.0 4.3e-07 30.5 0.0 1.9 1 1 0 1 1 1 1 SET domain Nop PF01798.18 EDO07437.1 - 6.8e-75 251.5 0.4 6.8e-75 251.5 0.4 2.1 2 1 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EDO07437.1 - 1.1e-17 64.2 0.0 1.1e-17 64.2 0.0 3.0 2 0 0 2 2 2 1 NOP5NT (NUC127) domain MOZ_SAS PF01853.18 EDO07439.1 - 4.1e-71 238.3 0.1 5.8e-71 237.8 0.1 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EDO07439.1 - 3.7e-20 71.3 3.0 1.7e-19 69.2 0.7 2.9 3 0 0 3 3 3 1 MYST family zinc finger domain Tudor-knot PF11717.8 EDO07439.1 - 2.4e-11 43.3 0.6 5.2e-11 42.3 0.6 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Orthopox_A43R PF06517.11 EDO07439.1 - 0.023 14.5 0.2 0.049 13.5 0.2 1.5 1 0 0 1 1 1 0 Orthopoxvirus A43R protein FF PF01846.19 EDO07439.1 - 0.13 12.5 0.2 0.39 10.9 0.0 1.9 2 0 0 2 2 2 0 FF domain Peptidase_M16_C PF05193.21 EDO07440.1 - 4.3e-18 66.0 0.1 1.5e-11 44.6 0.0 4.3 4 0 0 4 4 4 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EDO07440.1 - 2.1e-07 31.0 0.0 8.8e-07 29.0 0.0 2.0 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) HSP90 PF00183.18 EDO07441.1 - 2.2e-101 340.3 12.7 1.3e-98 331.2 9.5 2.1 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.6 EDO07441.1 - 2.2e-11 43.7 0.1 4.6e-11 42.7 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EDO07441.1 - 1.5e-08 35.1 0.2 4.2e-08 33.7 0.1 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Hen1_L PF12623.7 EDO07441.1 - 0.037 13.1 0.0 0.066 12.3 0.0 1.3 1 0 0 1 1 1 0 RNA repair, ligase-Pnkp-associating, region of Hen1 HP0268 PF18618.1 EDO07441.1 - 0.11 12.9 0.4 0.11 12.9 0.4 3.0 3 0 0 3 3 3 0 HP0268 Clat_adaptor_s PF01217.20 EDO07442.1 - 8.2e-48 161.9 4.4 9.3e-48 161.8 4.4 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF1098 PF06497.11 EDO07443.1 - 0.083 13.4 1.1 0.33 11.5 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1098) MarR PF01047.22 EDO07443.1 - 0.14 12.1 0.0 0.48 10.4 0.0 2.0 1 0 0 1 1 1 0 MarR family Mlh1_C PF16413.5 EDO07444.1 - 1.4e-31 109.9 0.1 2.8e-31 108.9 0.1 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 EDO07444.1 - 8.6e-26 90.0 0.5 2e-25 88.8 0.5 1.7 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EDO07444.1 - 4.3e-15 55.8 0.0 8.8e-15 54.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EDO07444.1 - 7.5e-08 32.9 0.0 2.2e-07 31.3 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Stevor PF17410.2 EDO07444.1 - 0.19 11.2 5.0 0.29 10.7 2.9 2.1 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame Arm-DNA-bind_5 PF17293.2 EDO07444.1 - 0.22 12.0 1.8 0.62 10.5 1.8 1.7 1 0 0 1 1 1 0 Arm DNA-binding domain Ras PF00071.22 EDO07445.1 - 1.5e-47 161.2 0.0 1.8e-47 160.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO07445.1 - 4.7e-30 104.3 0.0 9e-30 103.4 0.0 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO07445.1 - 1.5e-11 44.1 0.0 1.9e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EDO07445.1 - 2.4e-05 24.4 0.0 3.7e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 EDO07445.1 - 0.0017 18.7 0.0 0.0069 16.8 0.0 1.9 1 1 0 1 1 1 1 RNA helicase AAA_16 PF13191.6 EDO07445.1 - 0.0076 16.7 0.0 0.011 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EDO07445.1 - 0.011 15.6 0.0 0.4 10.6 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase Gtr1_RagA PF04670.12 EDO07445.1 - 0.015 14.6 0.0 0.021 14.2 0.0 1.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_7 PF12775.7 EDO07445.1 - 0.016 14.7 0.0 0.027 14.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ArgoMid PF16487.5 EDO07445.1 - 0.035 14.4 0.0 0.06 13.6 0.0 1.4 1 0 0 1 1 1 0 Mid domain of argonaute NB-ARC PF00931.22 EDO07445.1 - 0.044 13.0 0.1 0.067 12.4 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain G-alpha PF00503.20 EDO07445.1 - 0.06 12.5 0.2 1.2 8.2 0.1 2.6 2 1 1 3 3 3 0 G-protein alpha subunit TniB PF05621.11 EDO07445.1 - 0.092 12.1 0.0 0.4 10.0 0.0 2.0 3 0 0 3 3 3 0 Bacterial TniB protein ABC_tran PF00005.27 EDO07445.1 - 0.11 13.1 0.1 1.1 9.8 0.0 2.3 2 1 1 3 3 3 0 ABC transporter Septin PF00735.18 EDO07445.1 - 0.12 11.6 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Septin TsaE PF02367.17 EDO07445.1 - 0.16 12.0 0.1 0.29 11.1 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 EDO07445.1 - 0.17 12.1 0.1 0.58 10.4 0.1 1.8 2 0 0 2 2 2 0 AAA domain efThoc1 PF11957.8 EDO07446.1 - 1.5e-07 30.5 1.4 0.00022 20.1 0.2 3.1 2 1 0 2 2 2 2 THO complex subunit 1 transcription elongation factor tRNA-synt_1b PF00579.25 EDO07448.1 - 1.9e-40 139.1 0.2 8.6e-40 136.9 0.2 1.8 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) S4 PF01479.25 EDO07448.1 - 0.00042 20.0 0.1 0.0016 18.1 0.1 2.0 2 0 0 2 2 2 1 S4 domain DUF3273 PF11677.8 EDO07449.1 - 8.2e-103 343.3 14.7 9.4e-103 343.1 14.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) Clat_adaptor_s PF01217.20 EDO07451.1 - 4e-42 143.5 2.0 4.5e-42 143.3 2.0 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DEAD PF00270.29 EDO07452.1 - 4.4e-44 150.3 0.1 1.5e-43 148.6 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO07452.1 - 1.4e-33 115.6 0.2 2.2e-32 111.7 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO07452.1 - 2.4e-05 24.4 0.0 5.2e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EDO07452.1 - 0.0025 17.5 0.0 0.0038 17.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDO07452.1 - 0.031 14.6 0.1 0.086 13.2 0.1 1.8 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EDO07452.1 - 0.032 13.5 0.0 0.1 11.8 0.0 1.8 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 EDO07452.1 - 0.066 12.7 0.0 0.16 11.4 0.0 1.6 2 0 0 2 2 2 0 PhoH-like protein CMS1 PF14617.6 EDO07452.1 - 0.085 12.2 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit CAF1C_H4-bd PF12265.8 EDO07457.1 - 2e-19 69.6 0.1 1.3e-18 67.0 0.0 2.3 2 1 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EDO07457.1 - 1.1e-10 41.9 1.2 0.0076 17.1 0.0 5.0 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO07457.1 - 0.0029 17.9 0.7 2.3 8.6 0.1 3.4 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain LigD_N PF13298.6 EDO07457.1 - 0.081 13.2 0.0 2.1 8.7 0.0 2.4 2 0 0 2 2 2 0 DNA polymerase Ligase (LigD) Myosin_head PF00063.21 EDO07458.1 - 8e-201 668.8 0.2 1.1e-200 668.4 0.2 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.27 EDO07458.1 - 1.5e-11 43.0 30.6 0.0016 18.0 0.7 5.8 5 0 0 5 5 5 3 IQ calmodulin-binding motif WD40 PF00400.32 EDO07458.1 - 3.1e-05 24.7 2.1 4.5 8.3 0.0 6.5 7 0 0 7 7 6 1 WD domain, G-beta repeat AAA_16 PF13191.6 EDO07458.1 - 5.6e-05 23.6 0.4 0.36 11.2 0.0 3.5 3 0 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 EDO07458.1 - 0.00049 20.4 1.6 1.8 8.8 0.0 3.8 3 1 0 3 3 3 2 AAA domain Lipoprotein_6 PF01441.19 EDO07458.1 - 0.00068 19.7 2.7 0.0015 18.5 2.7 1.5 1 0 0 1 1 1 1 Lipoprotein Zeta_toxin PF06414.12 EDO07458.1 - 0.0031 16.8 0.1 3 7.1 0.0 2.7 2 0 0 2 2 2 2 Zeta toxin ANAPC4_WD40 PF12894.7 EDO07458.1 - 0.0054 17.0 0.0 1.7 9.0 0.0 3.9 3 1 0 4 4 3 1 Anaphase-promoting complex subunit 4 WD40 domain bZIP_1 PF00170.21 EDO07458.1 - 0.0054 16.8 1.6 0.016 15.3 1.6 1.8 1 0 0 1 1 1 1 bZIP transcription factor T2SSE PF00437.20 EDO07458.1 - 0.0088 15.1 0.0 3 6.8 0.0 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein Rad17 PF03215.15 EDO07458.1 - 0.048 13.6 0.2 16 5.3 0.0 2.6 2 1 0 2 2 2 0 Rad17 P-loop domain cobW PF02492.19 EDO07458.1 - 0.078 12.6 0.0 0.47 10.0 0.0 2.3 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 EDO07458.1 - 0.12 12.5 2.1 2.1 8.5 0.0 3.7 4 1 0 4 4 4 0 AAA domain Tropomyosin_1 PF12718.7 EDO07458.1 - 0.2 11.8 13.4 0.18 11.9 10.8 2.0 2 0 0 2 2 2 0 Tropomyosin like Macoilin PF09726.9 EDO07458.1 - 0.52 8.8 14.1 1.3 7.4 14.0 1.7 1 1 0 1 1 1 0 Macoilin family COG5 PF10392.9 EDO07458.1 - 0.53 10.5 5.6 14 5.9 1.5 2.6 2 0 0 2 2 2 0 Golgi transport complex subunit 5 DUF4407 PF14362.6 EDO07458.1 - 0.86 8.9 10.8 1.4 8.2 9.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DivIC PF04977.15 EDO07458.1 - 0.98 9.2 10.2 0.47 10.3 5.2 2.7 2 0 0 2 2 2 0 Septum formation initiator Peptidase_S46 PF10459.9 EDO07458.1 - 1.4 7.5 6.3 2.2 6.8 6.3 1.2 1 0 0 1 1 1 0 Peptidase S46 Atg14 PF10186.9 EDO07458.1 - 3.7 6.6 22.1 0.014 14.5 10.5 2.6 3 1 1 4 4 4 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4472 PF14739.6 EDO07458.1 - 6.1 7.6 10.2 1.1 10.0 5.7 2.1 2 0 0 2 2 1 0 Domain of unknown function (DUF4472) PI-PLC-X PF00388.19 EDO07459.1 - 3.3e-42 143.5 0.0 6.5e-42 142.5 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EDO07459.1 - 1.1e-25 90.2 0.3 3.4e-25 88.6 0.0 2.0 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 EDO07459.1 - 6.6e-10 39.2 0.0 9.2e-09 35.5 0.0 2.3 2 0 0 2 2 2 1 C2 domain Mcp5_PH PF12814.7 EDO07459.1 - 0.0006 19.9 0.0 0.0012 18.9 0.0 1.5 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology Utp14 PF04615.13 EDO07464.1 - 5.8e-24 84.7 62.9 3.8e-19 68.8 28.5 4.0 1 1 2 4 4 4 3 Utp14 protein PTase_Orf2 PF11468.8 EDO07464.1 - 0.084 12.3 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Aromatic prenyltransferase Orf2 SRP54_N PF02881.19 EDO07464.1 - 1.6 9.0 6.8 3.2 8.1 0.0 4.0 4 0 0 4 4 4 0 SRP54-type protein, helical bundle domain Myb_DNA-binding PF00249.31 EDO07465.1 - 2.5e-06 27.6 0.0 5.2e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDO07465.1 - 0.06 13.6 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain Nuc_deoxyri_tr2 PF15891.5 EDO07466.1 - 0.056 13.8 0.0 0.071 13.4 0.0 1.3 1 0 0 1 1 1 0 Nucleoside 2-deoxyribosyltransferase like RNA_pol_Rpc34 PF05158.12 EDO07467.1 - 2.4e-31 109.4 5.3 4.5e-27 95.3 0.6 2.6 1 1 1 2 2 2 2 RNA polymerase Rpc34 subunit B-block_TFIIIC PF04182.12 EDO07467.1 - 0.0011 19.1 0.0 0.0028 17.8 0.0 1.7 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC HTH_20 PF12840.7 EDO07467.1 - 0.026 14.6 0.0 0.053 13.6 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HA2 PF04408.23 EDO07468.1 - 2e-21 76.3 0.2 1.2e-20 73.8 0.0 2.3 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EDO07468.1 - 9.1e-16 58.0 0.1 1.9e-15 57.0 0.1 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EDO07468.1 - 9.8e-12 45.2 0.0 2.7e-11 43.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDO07468.1 - 4.1e-06 26.7 0.0 1.3e-05 25.1 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDO07468.1 - 1.1e-05 25.7 0.0 9.9e-05 22.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EDO07468.1 - 0.00093 19.5 0.0 0.0022 18.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EDO07468.1 - 0.0072 15.4 0.0 0.017 14.2 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.6 EDO07468.1 - 0.0075 16.0 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EDO07468.1 - 0.029 13.6 0.0 0.056 12.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_23 PF13476.6 EDO07468.1 - 0.95 9.9 0.0 0.95 9.9 0.0 3.4 3 1 0 3 3 2 0 AAA domain Dishevelled PF02377.15 EDO07468.1 - 3 8.3 7.3 0.6 10.6 3.5 1.7 2 0 0 2 2 2 0 Dishevelled specific domain DIM1 PF02966.16 EDO07469.1 - 1.1e-64 216.1 0.2 1.3e-64 215.9 0.2 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 EDO07469.1 - 0.0029 17.6 0.1 0.0039 17.2 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin FAM76 PF16046.5 EDO07470.1 - 8.2e-23 81.2 39.9 2.1e-22 79.9 38.5 2.1 1 1 0 1 1 1 1 FAM76 protein HALZ PF02183.18 EDO07470.1 - 0.0022 18.2 4.5 0.0043 17.2 4.5 1.5 1 0 0 1 1 1 1 Homeobox associated leucine zipper GrpE PF01025.19 EDO07470.1 - 0.017 14.8 2.3 0.035 13.8 2.3 1.5 1 0 0 1 1 1 0 GrpE EMP24_GP25L PF01105.24 EDO07470.1 - 0.018 15.0 2.3 0.018 15.0 2.3 1.6 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Tmemb_cc2 PF10267.9 EDO07470.1 - 0.041 13.0 3.9 0.03 13.5 1.3 1.8 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein JAKMIP_CC3 PF16034.5 EDO07470.1 - 0.054 13.4 7.8 0.066 13.2 2.4 2.2 2 0 0 2 2 2 0 JAKMIP CC3 domain DUF3810 PF12725.7 EDO07470.1 - 0.18 11.1 1.6 0.3 10.4 1.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) DivIC PF04977.15 EDO07470.1 - 0.28 11.0 5.3 0.22 11.3 1.8 2.3 2 0 0 2 2 2 0 Septum formation initiator PRKG1_interact PF15898.5 EDO07470.1 - 0.71 10.8 9.5 0.33 11.9 5.4 2.2 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain Cep57_MT_bd PF06657.13 EDO07470.1 - 0.88 10.1 4.4 0.27 11.7 1.1 1.9 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 CLZ PF16526.5 EDO07470.1 - 1 9.8 7.5 0.085 13.2 1.3 2.4 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ZapB PF06005.12 EDO07470.1 - 3.1 8.3 8.5 0.49 10.9 3.7 2.0 2 0 0 2 2 2 0 Cell division protein ZapB EF-hand_8 PF13833.6 EDO07471.1 - 0.071 13.0 0.1 4.6 7.2 0.1 2.4 2 0 0 2 2 2 0 EF-hand domain pair CDC50 PF03381.15 EDO07474.1 - 2.8e-20 73.0 1.3 2.9e-20 73.0 0.2 1.5 1 1 1 2 2 2 1 LEM3 (ligand-effect modulator 3) family / CDC50 family DUF4311 PF14188.6 EDO07474.1 - 0.012 15.4 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4311) Qn_am_d_aII PF14930.6 EDO07474.1 - 0.11 12.8 0.3 0.21 11.9 0.3 1.4 1 0 0 1 1 1 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain II AMA-1 PF02430.15 EDO07475.1 - 8.7e-189 628.3 3.3 1.1e-188 628.0 3.3 1.0 1 0 0 1 1 1 1 Apical membrane antigen 1 Molydop_binding PF01568.21 EDO07476.1 - 0.053 13.6 0.0 0.087 12.9 0.0 1.3 1 0 0 1 1 1 0 Molydopterin dinucleotide binding domain NARP1 PF12569.8 EDO07477.1 - 1.1e-27 97.2 11.8 1.3e-16 60.6 0.3 4.1 4 0 0 4 4 4 3 NMDA receptor-regulated protein 1 TPR_16 PF13432.6 EDO07477.1 - 9.9e-11 42.1 0.2 0.0035 18.0 0.0 4.8 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 EDO07477.1 - 1.4e-09 38.0 0.0 1.9 9.6 0.0 7.2 5 1 2 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 EDO07477.1 - 3.7e-09 36.0 17.3 0.44 10.8 0.1 7.5 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 EDO07477.1 - 1.5e-08 34.1 11.6 5.2e-05 22.9 0.1 5.8 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDO07477.1 - 1.4e-07 31.2 11.1 0.00077 19.5 0.1 5.8 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDO07477.1 - 3.9e-06 27.0 0.2 0.071 13.4 0.0 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDO07477.1 - 0.00079 19.9 4.7 5.1 8.0 0.3 5.1 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDO07477.1 - 0.0015 19.0 2.7 0.92 10.1 0.1 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 EDO07477.1 - 0.0016 18.7 0.3 0.36 11.3 0.0 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EDO07477.1 - 0.0051 16.9 0.4 0.3 11.2 0.1 3.4 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_21 PF09976.9 EDO07477.1 - 0.0073 16.0 1.4 0.92 9.2 0.2 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat-like domain ANAPC3 PF12895.7 EDO07477.1 - 0.016 15.4 9.8 0.04 14.1 0.1 4.3 4 1 0 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 DNApol3-delta_C PF09115.10 EDO07477.1 - 0.032 14.7 0.0 0.088 13.3 0.0 1.7 1 0 0 1 1 1 0 DNA polymerase III, delta subunit, C terminal Prp18 PF02840.15 EDO07478.1 - 6.3e-53 178.7 2.6 6.3e-53 178.7 2.6 2.7 2 1 0 2 2 2 1 Prp18 domain PRP4 PF08799.11 EDO07478.1 - 2.8e-08 33.2 0.2 5.3e-08 32.3 0.2 1.5 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like Fe_hyd_SSU PF02256.17 EDO07478.1 - 0.038 14.1 5.1 0.072 13.2 0.2 2.7 2 0 0 2 2 2 0 Iron hydrogenase small subunit DUF3683 PF12447.8 EDO07478.1 - 2 8.6 5.7 0.43 10.7 0.4 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3683) Ldh_1_N PF00056.23 EDO07479.1 - 7.8e-33 113.5 0.3 1.4e-32 112.7 0.3 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EDO07479.1 - 1.3e-24 87.0 0.0 2.6e-24 86.1 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.16 EDO07479.1 - 5.9e-05 22.7 0.3 0.00019 21.1 0.0 1.9 2 0 0 2 2 2 1 Family 4 glycosyl hydrolase DUF1168 PF06658.12 EDO07480.1 - 2.8e-19 69.3 9.5 3.7e-19 68.9 9.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) Peptidase_S30 PF01577.16 EDO07480.1 - 2 8.0 13.5 2.6 7.6 13.5 1.1 1 0 0 1 1 1 0 Potyvirus P1 protease Peptidase_S49_N PF08496.10 EDO07480.1 - 2.8 8.0 7.6 4 7.5 7.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal NAD_binding_1 PF00175.21 EDO07481.1 - 7.2e-16 58.8 0.0 9.5e-16 58.4 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EDO07481.1 - 0.00098 19.3 0.2 0.026 14.7 0.0 2.1 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Cnl2_NKP2 PF09447.10 EDO07482.1 - 0.1 12.8 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Cnl2/NKP2 family protein EGF_2 PF07974.13 EDO07483.1 - 0.04 14.3 4.9 0.04 14.3 4.9 4.1 4 1 0 4 4 4 0 EGF-like domain EGF_3 PF12947.7 EDO07483.1 - 0.042 14.1 8.1 0.042 14.1 8.1 4.0 2 1 1 3 3 3 0 EGF domain EGF PF00008.27 EDO07483.1 - 0.048 14.0 6.9 0.048 14.0 6.9 4.7 4 0 0 4 4 4 0 EGF-like domain hEGF PF12661.7 EDO07483.1 - 2.2 9.1 31.6 0.1 13.3 3.5 4.6 3 1 0 3 3 3 0 Human growth factor-like EGF Acetyltransf_1 PF00583.25 EDO07484.1 - 3.5e-12 46.6 0.0 4.1e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDO07484.1 - 1e-08 35.5 0.0 1.5e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EDO07484.1 - 6.8e-08 32.5 0.0 9.8e-08 32.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EDO07484.1 - 0.00011 22.3 0.0 0.00021 21.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EDO07484.1 - 0.0043 17.7 0.0 0.0053 17.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 EDO07484.1 - 0.036 14.0 0.0 0.073 13.1 0.0 1.5 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_8 PF13523.6 EDO07484.1 - 0.077 12.7 0.0 0.19 11.4 0.0 1.6 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain HECT PF00632.25 EDO07485.1 - 3.3e-42 145.1 0.0 6.6e-42 144.1 0.0 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Ank_5 PF13857.6 EDO07485.1 - 7e-06 26.2 0.4 0.035 14.4 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDO07485.1 - 2.3e-05 24.4 2.9 0.047 14.2 0.0 5.0 3 0 0 3 3 3 1 Ankyrin repeat Ank_2 PF12796.7 EDO07485.1 - 2.4e-05 24.9 0.0 0.00014 22.4 0.0 2.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EDO07485.1 - 0.0022 18.4 0.3 0.085 13.3 0.0 3.6 2 0 0 2 2 2 1 Ankyrin repeat PADR1 PF08063.12 EDO07485.1 - 0.0046 16.7 0.3 0.082 12.7 0.1 2.7 2 0 0 2 2 2 1 PADR1 (NUC008) domain UPF0086 PF01868.16 EDO07486.1 - 1.4e-07 31.3 0.0 2.6e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function UPF0086 SANT_DAMP1_like PF16282.5 EDO07487.1 - 1e-23 83.3 3.2 1e-23 83.3 3.2 2.4 3 0 0 3 3 3 1 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_6 PF13921.6 EDO07487.1 - 0.16 12.3 1.0 0.58 10.5 0.4 2.3 2 0 0 2 2 2 0 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EDO07487.1 - 0.69 10.2 2.5 1.6 9.0 0.0 2.5 2 0 0 2 2 2 0 Myb-like DNA-binding domain CDP-OH_P_transf PF01066.21 EDO07488.1 - 8.4e-14 52.1 0.1 8.4e-14 52.1 0.1 3.1 3 1 0 3 3 3 1 CDP-alcohol phosphatidyltransferase Pkinase PF00069.25 EDO07489.1 - 5.4e-29 101.4 0.0 4.6e-20 72.1 0.0 2.4 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO07489.1 - 1.5e-13 50.7 0.0 1.1e-08 34.7 0.0 2.8 3 0 0 3 3 3 2 Protein tyrosine kinase ERp29_N PF07912.13 EDO07489.1 - 0.075 13.2 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 ERp29, N-terminal domain Pox_ser-thr_kin PF05445.11 EDO07489.1 - 0.12 11.3 0.1 0.2 10.6 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase SF1-HH PF16275.5 EDO07490.1 - 3.7e-26 91.7 3.3 6.8e-26 90.8 0.0 2.6 2 0 0 2 2 2 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.29 EDO07490.1 - 1.9e-07 30.8 0.1 4.3e-07 29.6 0.1 1.6 1 0 0 1 1 1 1 KH domain zf-CCHC PF00098.23 EDO07490.1 - 1.2e-06 28.3 4.0 0.0013 18.7 0.8 2.6 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 EDO07490.1 - 1e-05 25.4 0.9 0.068 13.1 0.2 2.6 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 EDO07490.1 - 0.0076 16.0 6.8 0.33 10.7 0.6 2.6 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_6 PF15288.6 EDO07490.1 - 0.022 14.6 6.1 0.49 10.3 1.1 2.6 2 0 0 2 2 2 0 Zinc knuckle EIF4E-T PF10477.9 EDO07490.1 - 0.25 10.1 3.2 0.084 11.7 0.8 1.5 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E zf-LSD1 PF06943.12 EDO07490.1 - 0.96 9.3 5.2 4.4 7.3 0.2 2.4 2 0 0 2 2 2 0 LSD1 zinc finger PEP-utilisers_N PF05524.13 EDO07491.1 - 0.12 12.6 1.1 3.3 7.9 0.1 2.9 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal MFS_1 PF07690.16 EDO07492.1 - 2e-25 89.5 34.9 2.9e-25 89.0 32.6 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EDO07492.1 - 0.00024 20.1 17.9 0.028 13.3 12.9 3.6 1 1 0 2 2 2 2 MFS_1 like family Helicase_C PF00271.31 EDO07493.1 - 1.9e-12 47.5 0.2 6.3e-12 45.8 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SUV3_C PF12513.8 EDO07493.1 - 4.6e-12 45.7 0.0 1.3e-11 44.3 0.0 1.7 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Cohesin_load PF10345.9 EDO07493.1 - 0.05 12.1 1.2 0.079 11.4 1.2 1.3 1 0 0 1 1 1 0 Cohesin loading factor Nbl1_Borealin_N PF10444.9 EDO07494.1 - 0.18 11.4 0.6 2 8.1 0.0 2.3 2 0 0 2 2 2 0 Nbl1 / Borealin N terminal PAS_10 PF13596.6 EDO07495.1 - 0.026 15.1 0.3 0.32 11.6 0.1 2.9 3 0 0 3 3 3 0 PAS domain Helicase_C PF00271.31 EDO07496.1 - 2.5e-12 47.1 0.0 7.7e-12 45.5 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain GUCT PF08152.12 EDO07496.1 - 6.9e-05 23.1 0.0 0.00019 21.6 0.0 1.8 1 0 0 1 1 1 1 GUCT (NUC152) domain RAP PF08373.10 EDO07497.1 - 0.0099 16.0 0.2 0.063 13.4 0.2 2.3 2 0 0 2 2 2 1 RAP domain AAA PF00004.29 EDO07498.1 - 5.6e-85 282.4 0.0 9.2e-47 158.8 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO07498.1 - 5.2e-27 93.4 0.7 1e-12 47.6 0.1 2.8 2 0 0 2 2 2 2 AAA+ lid domain AAA_2 PF07724.14 EDO07498.1 - 6.8e-11 42.6 0.0 2.3e-05 24.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EDO07498.1 - 1.2e-10 41.4 0.0 0.00018 21.3 0.0 3.0 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDO07498.1 - 1.4e-10 41.8 0.9 0.0025 18.2 0.0 3.8 2 2 1 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 EDO07498.1 - 1.4e-10 41.3 0.1 0.00041 20.4 0.0 3.2 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDO07498.1 - 1.9e-09 37.9 0.1 0.0045 17.3 0.0 3.8 2 2 1 3 3 3 2 AAA domain AAA_33 PF13671.6 EDO07498.1 - 4.6e-09 36.6 0.1 0.00052 20.2 0.0 2.8 3 0 0 3 3 2 2 AAA domain IstB_IS21 PF01695.17 EDO07498.1 - 2.5e-08 33.9 0.0 0.0033 17.2 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.6 EDO07498.1 - 5.2e-07 30.3 0.0 0.046 14.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 EDO07498.1 - 7.7e-07 29.2 0.0 0.0042 17.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 EDO07498.1 - 1.5e-06 28.0 0.0 0.6 9.8 0.0 3.7 3 1 0 3 3 3 2 Sigma-54 interaction domain RNA_helicase PF00910.22 EDO07498.1 - 1.6e-06 28.5 0.0 0.054 13.9 0.0 3.2 4 0 0 4 4 2 2 RNA helicase ABC_tran PF00005.27 EDO07498.1 - 1.8e-06 28.5 0.0 0.1 13.1 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_25 PF13481.6 EDO07498.1 - 3.5e-06 26.7 2.0 1.6 8.3 0.1 4.3 3 1 0 4 4 4 1 AAA domain Mg_chelatase PF01078.21 EDO07498.1 - 4e-06 26.4 1.6 0.035 13.5 0.1 2.9 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 EDO07498.1 - 9.5e-06 25.0 0.2 0.095 11.9 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_28 PF13521.6 EDO07498.1 - 3.5e-05 24.1 0.1 0.29 11.4 0.0 2.6 2 1 0 2 2 2 2 AAA domain CPT PF07931.12 EDO07498.1 - 9.1e-05 22.4 0.0 0.0041 17.0 0.0 2.4 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein NACHT PF05729.12 EDO07498.1 - 0.0001 22.3 0.1 0.65 9.9 0.1 2.9 3 0 0 3 3 3 2 NACHT domain TsaE PF02367.17 EDO07498.1 - 0.00011 22.2 0.0 0.034 14.1 0.0 2.3 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 EDO07498.1 - 0.00011 21.5 0.1 0.46 9.7 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin AAA_24 PF13479.6 EDO07498.1 - 0.00024 20.9 0.0 0.17 11.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 EDO07498.1 - 0.00035 20.4 0.0 0.29 10.8 0.0 2.3 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.11 EDO07498.1 - 0.00056 19.8 0.0 1.2 9.0 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EDO07498.1 - 0.00086 19.3 0.0 0.31 10.9 0.0 2.6 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea Parvo_NS1 PF01057.17 EDO07498.1 - 0.0017 17.5 0.2 0.59 9.2 0.1 2.3 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 NB-ARC PF00931.22 EDO07498.1 - 0.0017 17.6 0.0 0.68 9.1 0.0 2.4 2 0 0 2 2 2 1 NB-ARC domain DUF815 PF05673.13 EDO07498.1 - 0.0024 17.1 0.0 1.4 8.0 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_17 PF13207.6 EDO07498.1 - 0.0037 17.7 2.0 2.8 8.4 0.0 2.8 3 0 0 3 3 2 2 AAA domain Nucleolin_bd PF16725.5 EDO07498.1 - 0.005 16.5 0.1 0.01 15.4 0.1 1.5 1 0 0 1 1 1 1 Nucleolin binding domain AAA_7 PF12775.7 EDO07498.1 - 0.0055 16.2 0.1 2.1 7.8 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_29 PF13555.6 EDO07498.1 - 0.006 16.3 0.0 0.37 10.6 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_11 PF13086.6 EDO07498.1 - 0.014 15.2 0.0 3.4 7.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain Vps4_C PF09336.10 EDO07498.1 - 0.027 14.5 0.0 0.21 11.6 0.0 2.4 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain Rad17 PF03215.15 EDO07498.1 - 0.029 14.3 0.1 3.6 7.5 0.0 2.7 2 1 0 2 2 2 0 Rad17 P-loop domain SMC_N PF02463.19 EDO07498.1 - 0.035 13.5 0.1 2.7 7.4 0.0 3.0 2 1 0 3 3 3 0 RecF/RecN/SMC N terminal domain PduV-EutP PF10662.9 EDO07498.1 - 0.036 13.8 0.0 15 5.3 0.0 3.2 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.6 EDO07498.1 - 0.051 13.3 0.1 8.5 6.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 EDO07498.1 - 0.054 12.8 0.2 1 8.6 0.0 2.5 2 0 0 2 2 2 0 KaiC AAA_19 PF13245.6 EDO07498.1 - 0.056 13.8 0.1 11 6.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EDO07498.1 - 0.076 12.9 0.0 8.5 6.3 0.0 2.5 2 0 0 2 2 2 0 NTPase PhoH PF02562.16 EDO07498.1 - 0.15 11.5 0.3 5.4 6.4 0.1 2.4 2 0 0 2 2 2 0 PhoH-like protein DAP3 PF10236.9 EDO07498.1 - 0.18 11.0 0.0 4.4 6.4 0.0 2.1 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_23 PF13476.6 EDO07498.1 - 0.2 12.2 0.0 15 6.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 EDO07498.1 - 0.71 9.6 4.6 2.3 7.9 0.0 2.6 3 0 0 3 3 2 0 Cytidylate kinase DDHD PF02862.17 EDO07499.1 - 1.3e-34 120.3 0.5 2.9e-34 119.2 0.0 1.8 2 0 0 2 2 2 1 DDHD domain Abhydrolase_1 PF00561.20 EDO07499.1 - 0.054 13.1 0.1 0.36 10.4 0.0 2.2 2 0 0 2 2 2 0 alpha/beta hydrolase fold DUF676 PF05057.14 EDO07499.1 - 0.17 11.4 0.4 1.1 8.7 0.4 2.3 1 1 0 1 1 1 0 Putative serine esterase (DUF676) Sod_Fe_C PF02777.18 EDO07500.1 - 1.4e-37 127.9 0.4 5.4e-37 126.1 0.0 2.0 3 0 0 3 3 3 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EDO07500.1 - 9.7e-29 99.7 1.2 9.8e-29 99.7 0.1 1.6 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain RAP PF08373.10 EDO07502.1 - 4e-17 62.1 0.3 1.1e-16 60.6 0.3 1.9 1 0 0 1 1 1 1 RAP domain MTES_1575 PF18741.1 EDO07502.1 - 0.11 12.7 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 REase_MTES_1575 DnaJ PF00226.31 EDO07504.1 - 9.9e-19 67.2 0.6 3.5e-18 65.5 0.1 2.1 2 0 0 2 2 2 1 DnaJ domain DUF1977 PF09320.11 EDO07504.1 - 0.0004 20.6 1.1 0.0012 19.1 1.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) PBP_GOBP PF01395.22 EDO07504.1 - 0.0043 17.2 1.7 0.015 15.5 0.4 2.2 2 0 0 2 2 2 1 PBP/GOBP family TPR_2 PF07719.17 EDO07504.1 - 0.012 15.7 0.0 0.052 13.7 0.0 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EDO07504.1 - 0.097 12.9 0.2 0.37 11.1 0.1 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat SPRY PF00622.28 EDO07505.1 - 0.0039 17.3 0.0 1.4 9.1 0.0 2.6 3 0 0 3 3 3 2 SPRY domain CLPTM1 PF05602.12 EDO07506.1 - 3.3e-95 319.6 7.4 3.9e-95 319.4 7.4 1.0 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 EDO07506.1 - 5.8e-08 32.4 1.2 0.0045 16.7 0.1 3.0 2 0 0 2 2 2 2 PQ loop repeat Peptidase_M18 PF02127.15 EDO07507.1 - 9.9e-90 301.4 0.5 1.8e-75 254.4 0.1 2.2 1 1 1 2 2 2 2 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 EDO07507.1 - 6.8e-06 25.3 0.1 0.0011 18.1 0.0 3.1 2 1 0 2 2 2 2 M42 glutamyl aminopeptidase Carot_N PF09150.10 EDO07507.1 - 0.18 11.6 0.0 0.32 10.8 0.0 1.3 1 0 0 1 1 1 0 Orange carotenoid protein, N-terminal Exo_endo_phos PF03372.23 EDO07508.1 - 9.7e-11 41.6 0.0 1.9e-10 40.7 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Cytochrome_B PF00033.19 EDO07508.1 - 0.11 12.3 0.1 0.2 11.5 0.1 1.4 1 0 0 1 1 1 0 Cytochrome b/b6/petB Syja_N PF02383.18 EDO07509.1 - 1.1e-54 185.9 0.0 1.6e-54 185.4 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 EDO07509.1 - 4e-11 42.9 0.0 7.1e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Helicase_C PF00271.31 EDO07510.1 - 1.6e-20 73.5 0.0 5.6e-20 71.7 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDO07510.1 - 1.4e-12 47.8 0.0 6.4e-12 45.6 0.0 2.0 2 1 0 2 2 2 1 DEAD/DEAH box helicase GPI2 PF06432.11 EDO07512.1 - 1.8e-10 40.7 0.0 2.3e-10 40.4 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase Acylphosphatase PF00708.18 EDO07517.1 - 1.6e-24 86.1 0.2 1.8e-24 85.9 0.2 1.0 1 0 0 1 1 1 1 Acylphosphatase DUF2871 PF11070.8 EDO07517.1 - 0.17 12.2 0.2 0.23 11.7 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2871) DSPc PF00782.20 EDO07518.1 - 5.5e-08 32.7 0.0 1.3e-07 31.5 0.0 1.6 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EDO07518.1 - 5.5e-05 22.8 0.0 7.6e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF1411 PF07199.11 EDO07519.1 - 0.0049 16.6 0.1 0.0086 15.8 0.1 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1411) DUF1411 PF07199.11 EDO07520.1 - 7.7e-05 22.4 0.0 0.27 10.9 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1411) DUF3340 PF11818.8 EDO07520.1 - 0.099 12.8 0.1 0.24 11.5 0.0 1.7 2 0 0 2 2 2 0 C-terminal domain of tail specific protease (DUF3340) AP2 PF00847.20 EDO07521.1 - 1.3e-05 25.3 1.2 0.00089 19.5 0.5 2.8 2 0 0 2 2 2 2 AP2 domain TPR_1 PF00515.28 EDO07522.1 - 4.2e-06 26.3 2.9 0.0012 18.6 0.1 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDO07522.1 - 1.4e-05 24.8 2.4 0.079 13.1 0.2 3.1 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDO07522.1 - 0.02 15.1 0.1 9.6 6.6 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat DnaB_bind PF10410.9 EDO07522.1 - 0.048 13.9 0.4 11 6.3 0.1 3.2 2 1 1 3 3 3 0 DnaB-helicase binding domain of primase TPR_7 PF13176.6 EDO07522.1 - 0.13 12.3 0.0 18 5.7 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat RPA_interact_N PF14766.6 EDO07522.1 - 2.7 7.7 5.3 10 5.9 0.1 2.7 3 0 0 3 3 3 0 Replication protein A interacting N-terminal ubiquitin PF00240.23 EDO07523.1 - 7.1e-20 70.5 0.0 1.3e-19 69.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EDO07523.1 - 2.8e-09 36.7 0.1 5.5e-09 35.7 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.31 EDO07523.1 - 0.00021 21.1 0.3 0.00085 19.2 0.1 2.2 2 0 0 2 2 2 1 UBA/TS-N domain Ubiquitin_2 PF14560.6 EDO07523.1 - 0.0005 20.5 0.0 0.0012 19.2 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EDO07523.1 - 0.039 14.1 0.0 0.064 13.4 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EDO07523.1 - 0.058 13.9 0.0 0.11 13.0 0.0 1.4 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Med13_C PF06333.12 EDO07523.1 - 0.3 10.3 2.9 0.41 9.9 2.9 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain XPC-binding PF09280.11 EDO07523.1 - 0.35 10.6 26.2 0.13 12.0 13.2 3.9 3 1 0 3 3 3 0 XPC-binding domain CUE PF02845.16 EDO07523.1 - 1.2 9.0 3.3 1.2 8.9 0.1 2.4 2 0 0 2 2 2 0 CUE domain UAA PF08449.11 EDO07524.1 - 9e-39 133.5 16.6 1.4e-38 132.9 16.6 1.3 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 EDO07524.1 - 0.00022 21.4 27.5 0.026 14.7 3.6 2.6 2 1 0 2 2 2 2 EamA-like transporter family ESP PF16590.5 EDO07524.1 - 0.013 15.7 0.2 0.095 13.0 0.1 2.1 2 0 0 2 2 2 0 Exocrine gland-secreting peptide UFD1 PF03152.14 EDO07525.1 - 1.5e-33 115.7 0.0 5.3e-33 113.9 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 hemP PF10636.9 EDO07525.1 - 0.037 13.8 0.5 0.073 12.9 0.5 1.4 1 0 0 1 1 1 0 Hemin uptake protein hemP DUF1319 PF07028.11 EDO07526.1 - 0.15 12.3 1.6 2.5 8.4 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1319) PRORP PF16953.5 EDO07527.1 - 0.00071 19.2 0.0 0.65 9.5 0.1 3.1 4 0 0 4 4 4 2 Protein-only RNase P OMPdecase PF00215.24 EDO07528.1 - 6e-28 98.0 0.0 7.9e-28 97.6 0.0 1.2 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family SNF2_N PF00176.23 EDO07529.1 - 1.2e-63 214.9 0.5 1.2e-63 214.9 0.5 1.8 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDO07529.1 - 1.1e-18 67.5 0.3 5.3e-18 65.4 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO07529.1 - 2.4e-05 24.4 0.0 0.00023 21.2 0.0 2.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HSA PF07529.13 EDO07529.1 - 1.8 8.9 7.2 2.3 8.6 1.3 3.1 1 1 1 2 2 2 0 HSA Ribosomal_L22 PF00237.19 EDO07530.1 - 0.063 13.5 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L22p/L17e PLDc_2 PF13091.6 EDO07531.1 - 6.8e-12 45.4 0.0 4.2e-05 23.4 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EDO07531.1 - 7.2e-05 22.8 2.0 0.012 15.8 0.1 3.3 3 1 0 3 3 3 2 Phospholipase D Active site motif YHYH PF14240.6 EDO07531.1 - 0.014 15.4 0.3 0.034 14.1 0.2 1.6 1 1 1 2 2 2 0 YHYH protein Ribosomal_L23 PF00276.20 EDO07534.1 - 1.4e-13 51.0 0.0 4.8e-13 49.3 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L23 ACDC PF14733.6 EDO07535.1 - 5e-19 68.4 0.0 8.4e-19 67.7 0.0 1.4 1 0 0 1 1 1 1 AP2-coincident C-terminal AP2 PF00847.20 EDO07535.1 - 1.8e-08 34.5 1.8 4e-08 33.4 1.8 1.6 1 0 0 1 1 1 1 AP2 domain DUF2721 PF11026.8 EDO07536.1 - 2.1 8.2 3.9 4.1 7.3 3.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) DNA_gyraseB PF00204.25 EDO07537.1 - 5.2e-44 149.8 0.3 1e-43 148.8 0.3 1.5 1 0 0 1 1 1 1 DNA gyrase B DNA_gyraseB_C PF00986.21 EDO07537.1 - 3.7e-24 84.7 1.7 7.1e-24 83.8 1.7 1.5 1 0 0 1 1 1 1 DNA gyrase B subunit, carboxyl terminus Toprim PF01751.22 EDO07537.1 - 3.4e-15 56.1 0.0 3e-14 53.1 0.0 2.4 1 1 0 1 1 1 1 Toprim domain HATPase_c PF02518.26 EDO07537.1 - 1.3e-13 51.4 0.0 5.4e-12 46.2 0.0 3.4 3 1 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EDO07537.1 - 0.042 13.7 0.0 0.098 12.5 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HK PF02110.15 EDO07538.1 - 0.00065 19.2 0.2 0.0012 18.3 0.2 1.4 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family Peptidase_S41 PF03572.18 EDO07538.1 - 0.16 11.5 0.2 0.35 10.4 0.0 1.6 2 0 0 2 2 2 0 Peptidase family S41 Peptidase_M41 PF01434.18 EDO07539.1 - 5.1e-62 209.1 0.2 7.7e-62 208.5 0.2 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EDO07539.1 - 1.8e-43 148.2 0.0 3e-43 147.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO07539.1 - 5.5e-16 58.1 0.2 3e-15 55.7 0.0 2.2 2 0 0 2 2 2 1 AAA+ lid domain RuvB_N PF05496.12 EDO07539.1 - 4.8e-07 29.7 0.0 3.2e-06 27.0 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDO07539.1 - 9.2e-07 29.4 0.0 0.00092 19.6 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EDO07539.1 - 2e-05 24.6 0.0 7e-05 22.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDO07539.1 - 2.3e-05 24.7 0.0 0.0089 16.3 0.0 3.4 1 1 2 3 3 3 1 AAA domain TIP49 PF06068.13 EDO07539.1 - 9e-05 21.8 0.0 0.00018 20.8 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_28 PF13521.6 EDO07539.1 - 0.00045 20.5 0.9 0.0078 16.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 EDO07539.1 - 0.00069 19.8 0.0 0.0019 18.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 EDO07539.1 - 0.0015 18.0 0.0 0.0027 17.1 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EDO07539.1 - 0.0018 18.0 0.0 0.0034 17.1 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein NACHT PF05729.12 EDO07539.1 - 0.0027 17.7 0.9 0.078 12.9 0.0 2.7 3 0 0 3 3 2 1 NACHT domain AAA_7 PF12775.7 EDO07539.1 - 0.0031 17.1 0.0 0.0072 15.9 0.0 1.5 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_33 PF13671.6 EDO07539.1 - 0.0057 16.8 0.0 0.015 15.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EDO07539.1 - 0.0064 16.9 0.2 0.016 15.6 0.0 1.8 2 0 0 2 2 1 1 AAA domain DUF815 PF05673.13 EDO07539.1 - 0.014 14.6 0.0 0.024 13.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_30 PF13604.6 EDO07539.1 - 0.019 14.7 0.8 0.34 10.6 0.1 2.5 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EDO07539.1 - 0.019 15.5 0.0 0.042 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EDO07539.1 - 0.039 14.0 0.0 0.076 13.0 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EDO07539.1 - 0.042 13.9 0.0 0.087 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EDO07539.1 - 0.061 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_24 PF13479.6 EDO07539.1 - 0.061 13.0 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EDO07539.1 - 0.067 12.5 0.4 0.16 11.3 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin Sigma54_activat PF00158.26 EDO07539.1 - 0.086 12.5 0.0 0.21 11.3 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_25 PF13481.6 EDO07539.1 - 0.11 12.1 0.1 0.33 10.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain DUF1488 PF07369.11 EDO07539.1 - 0.17 11.9 0.7 0.42 10.7 0.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1488) ABC_tran PF00005.27 EDO07539.1 - 0.17 12.4 1.0 1.2 9.7 0.0 2.8 4 0 0 4 4 3 0 ABC transporter Vps16_N PF04841.13 EDO07540.1 - 2.5e-19 69.4 0.0 1.9e-13 49.9 0.0 2.1 2 0 0 2 2 2 2 Vps16, N-terminal region Vps16_C PF04840.12 EDO07540.1 - 5.9e-09 35.4 0.0 5.5e-07 28.9 0.0 2.3 1 1 0 1 1 1 1 Vps16, C-terminal region WD40 PF00400.32 EDO07541.1 - 7.8e-23 80.3 13.0 8e-05 23.3 0.1 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat Ribosomal_L1 PF00687.21 EDO07541.1 - 1.2e-14 54.6 0.0 1.9e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family ANAPC4_WD40 PF12894.7 EDO07541.1 - 5.8e-14 52.2 0.1 0.00062 20.0 0.1 4.9 3 2 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDO07541.1 - 5.7e-06 26.3 0.0 0.0049 16.8 0.0 3.2 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EDO07541.1 - 0.0035 16.3 0.0 1.4 7.8 0.0 3.0 3 0 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 EDO07541.1 - 0.064 11.3 0.0 0.58 8.1 0.0 2.3 3 0 0 3 3 3 0 IKI3 family SelR PF01641.18 EDO07543.1 - 0.039 14.0 0.5 0.094 12.8 0.5 1.6 1 0 0 1 1 1 0 SelR domain Fibrillin_U_N PF18193.1 EDO07544.1 - 0.068 13.3 0.6 20 5.4 0.0 3.1 3 0 0 3 3 3 0 Fibrillin 1 unique N-terminal domain Rpp20 PF12328.8 EDO07545.1 - 9.2e-07 28.9 0.0 0.047 13.6 0.0 2.6 2 1 0 2 2 2 2 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 EDO07545.1 - 0.0023 17.7 0.0 0.011 15.5 0.0 2.2 2 1 0 2 2 2 1 Alba SeqA PF03925.13 EDO07545.1 - 0.077 12.9 0.0 0.22 11.5 0.0 1.7 2 0 0 2 2 2 0 SeqA protein C-terminal domain RPAP2_Rtr1 PF04181.13 EDO07547.1 - 5.7e-11 42.6 0.2 1.1e-10 41.6 0.2 1.5 1 0 0 1 1 1 1 Rtr1/RPAP2 family CofC PF01983.16 EDO07547.1 - 0.048 12.8 0.0 0.1 11.8 0.0 1.5 1 0 0 1 1 1 0 Guanylyl transferase CofC like Cpn60_TCP1 PF00118.24 EDO07548.1 - 1.1e-154 515.7 5.8 1.3e-154 515.5 5.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family ADH_zinc_N PF00107.26 EDO07548.1 - 0.0057 16.6 0.0 0.017 15.1 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FlgI PF02119.16 EDO07549.1 - 0.13 11.1 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Flagellar P-ring protein zf-CCHC PF00098.23 EDO07550.1 - 1.2e-05 25.1 3.5 2.1e-05 24.3 3.5 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 EDO07550.1 - 0.097 12.4 1.3 0.17 11.6 1.3 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.6 EDO07550.1 - 0.73 9.6 3.9 1.6 8.5 3.9 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger PRIMA1 PF16101.5 EDO07550.1 - 3 7.9 11.8 11 6.0 0.4 2.5 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 zf-C3HC4_3 PF13920.6 EDO07552.1 - 2.4e-13 49.7 15.9 3.9e-13 49.0 15.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDO07552.1 - 7.2e-06 25.8 17.7 1.3e-05 24.9 17.7 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EDO07552.1 - 3e-05 24.2 15.4 6e-05 23.3 15.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EDO07552.1 - 0.009 16.0 14.4 0.017 15.0 14.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EDO07552.1 - 0.013 15.3 16.9 0.025 14.4 16.9 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-P11 PF03854.14 EDO07552.1 - 0.32 10.7 9.0 0.66 9.7 9.0 1.5 1 0 0 1 1 1 0 P-11 zinc finger zf-RING_4 PF14570.6 EDO07552.1 - 1.7 8.5 10.4 3.6 7.5 10.4 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DZR PF12773.7 EDO07552.1 - 4.8 7.3 11.3 0.6 10.2 4.0 1.8 1 1 1 2 2 2 0 Double zinc ribbon PqiA PF04403.13 EDO07554.1 - 6.6e-10 39.0 14.0 3e-06 27.2 5.4 2.7 2 0 0 2 2 2 2 Paraquat-inducible protein A Myosin_head PF00063.21 EDO07555.1 - 7e-175 583.1 0.1 9.7e-175 582.6 0.1 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) RCC1 PF00415.18 EDO07555.1 - 5.6e-20 71.7 11.4 4.2e-10 40.1 0.2 4.8 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat IQ PF00612.27 EDO07555.1 - 1.7e-13 49.0 24.5 0.00012 21.6 0.6 6.6 6 0 0 6 6 6 5 IQ calmodulin-binding motif RCC1_2 PF13540.6 EDO07555.1 - 4.5e-13 48.6 33.9 2e-05 24.2 1.1 6.4 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat Stress-antifung PF01657.17 EDO07555.1 - 0.0028 18.3 0.1 0.15 12.7 0.0 3.2 2 0 0 2 2 2 1 Salt stress response/antifungal AAA_22 PF13401.6 EDO07555.1 - 0.0077 16.5 0.0 0.025 14.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain CagY_M PF07337.11 EDO07555.1 - 0.019 14.6 0.0 0.05 13.2 0.0 1.7 1 0 0 1 1 1 0 DC-EC Repeat AAA_16 PF13191.6 EDO07555.1 - 0.04 14.3 0.0 0.13 12.6 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain DUF4213 PF13938.6 EDO07555.1 - 0.089 13.0 0.0 0.35 11.1 0.0 2.1 1 0 0 1 1 1 0 Putative heavy-metal chelation Myc-LZ PF02344.15 EDO07556.1 - 0.034 14.3 1.7 0.061 13.4 1.7 1.4 1 0 0 1 1 1 0 Myc leucine zipper domain Pkinase PF00069.25 EDO07557.1 - 1.6e-22 80.2 0.2 3.4e-22 79.1 0.2 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO07557.1 - 4e-06 26.3 1.0 2.5e-05 23.7 1.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase ArfGap PF01412.18 EDO07558.1 - 4.9e-30 104.0 0.6 1.1e-29 102.8 0.1 1.8 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Pro_isomerase PF00160.21 EDO07559.1 - 4.5e-38 131.0 0.1 5.3e-38 130.8 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rep_1B PF17873.1 EDO07559.1 - 0.67 9.9 5.4 3.6 7.5 1.7 2.4 2 0 0 2 2 2 0 Replicase polyprotein 1ab PseudoU_synth_1 PF01416.20 EDO07560.1 - 8.3e-18 64.8 0.0 1.2e-14 54.7 0.0 2.6 2 0 0 2 2 2 2 tRNA pseudouridine synthase DUF2208 PF09973.9 EDO07562.1 - 0.21 11.2 0.1 0.21 11.2 0.1 3.8 2 2 1 4 4 4 0 Predicted membrane protein (DUF2208) DUF2207 PF09972.9 EDO07563.1 - 0.0011 17.8 0.3 0.0013 17.6 0.3 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Orai-1 PF07856.12 EDO07563.1 - 0.011 15.4 0.3 0.016 14.9 0.3 1.2 1 0 0 1 1 1 0 Mediator of CRAC channel activity TMEM192 PF14802.6 EDO07563.1 - 0.015 14.4 1.0 0.015 14.4 1.0 1.5 2 0 0 2 2 2 0 TMEM192 family DUF1422 PF07226.11 EDO07563.1 - 0.024 14.6 1.9 0.024 14.6 1.9 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1422) DUF5009 PF16401.5 EDO07563.1 - 0.036 13.6 1.4 0.057 12.9 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5009) PIRT PF15099.6 EDO07563.1 - 0.04 13.5 0.1 0.055 13.0 0.1 1.4 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family DUF4519 PF15012.6 EDO07563.1 - 0.067 13.4 0.7 0.57 10.4 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) DUF3671 PF12420.8 EDO07563.1 - 0.074 13.1 4.2 0.15 12.2 4.2 1.5 1 0 0 1 1 1 0 Protein of unknown function Cadherin_C_2 PF16492.5 EDO07563.1 - 0.091 13.5 4.4 0.91 10.3 3.3 2.6 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal Insulin_TMD PF17870.1 EDO07563.1 - 7.5 6.7 11.8 4.2 7.5 1.5 2.3 1 1 1 2 2 2 0 Insulin receptor trans-membrane segment DUF962 PF06127.11 EDO07564.1 - 0.018 15.1 0.0 0.18 11.9 0.0 2.8 2 2 0 2 2 2 0 Protein of unknown function (DUF962) RPAP1_C PF08620.10 EDO07564.1 - 0.18 11.9 0.0 0.41 10.8 0.0 1.5 1 0 0 1 1 1 0 RPAP1-like, C-terminal DUF2231 PF09990.9 EDO07564.1 - 0.4 11.1 17.0 0.77 10.2 2.1 4.1 2 1 3 5 5 5 0 Predicted membrane protein (DUF2231) VESA1_N PF12785.7 EDO07565.1 - 3.1e-80 270.4 33.0 3.7e-80 270.1 33.0 1.0 1 0 0 1 1 1 1 Variant erythrocyte surface antigen-1 F-box-like_2 PF13013.6 EDO07566.1 - 2.7e-06 27.3 1.1 0.00014 21.8 0.1 2.3 2 1 1 3 3 3 2 F-box-like domain VESA1_N PF12785.7 EDO07567.1 - 5.6e-09 35.5 29.4 4e-05 22.8 25.5 2.8 1 1 1 2 2 2 2 Variant erythrocyte surface antigen-1 DUF2070 PF09843.9 EDO07568.1 - 1.4 7.1 8.9 1.9 6.7 8.9 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF2207 PF09972.9 EDO07569.1 - 0.11 11.3 0.1 0.12 11.1 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) F-box-like_2 PF13013.6 EDO07571.1 - 7.5e-07 29.1 0.3 1.3e-06 28.3 0.3 1.4 1 0 0 1 1 1 1 F-box-like domain Methyltransf_28 PF02636.17 EDO07571.1 - 0.032 13.9 0.0 0.039 13.6 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase VESA1_N PF12785.7 EDO07573.1 - 2.3e-186 620.2 31.9 2.3e-186 620.2 31.9 2.8 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 PEP-utilisers_N PF05524.13 EDO07573.1 - 0.015 15.4 0.7 0.91 9.7 0.0 2.4 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal Spc7 PF08317.11 EDO07573.1 - 0.082 11.8 4.3 0.095 11.6 0.3 2.4 3 0 0 3 3 3 0 Spc7 kinetochore protein ApoLp-III PF07464.11 EDO07573.1 - 0.097 12.8 5.6 0.3 11.2 4.7 2.1 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) SesA PF17107.5 EDO07573.1 - 0.24 11.6 2.1 0.9 9.7 0.2 2.6 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF1542 PF07564.11 EDO07573.1 - 0.7 10.0 6.8 0.17 12.0 1.2 2.5 2 1 1 3 3 3 0 Domain of Unknown Function (DUF1542) DUF2408 PF10303.9 EDO07573.1 - 0.98 10.0 6.8 62 4.2 6.0 3.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2408) HAUS-augmin3 PF14932.6 EDO07573.1 - 3.3 7.2 6.1 5.5 6.5 0.9 2.3 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 Prefoldin_2 PF01920.20 EDO07573.1 - 5.2 7.1 12.0 15 5.6 4.3 2.6 2 0 0 2 2 2 0 Prefoldin subunit CC2-LZ PF16516.5 EDO07573.1 - 6 7.3 5.5 16 6.0 1.2 2.5 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator F-box-like_2 PF13013.6 EDO07574.1 - 2.1e-30 104.8 2.8 1.3e-26 92.7 1.6 2.2 2 0 0 2 2 2 2 F-box-like domain NOT2_3_5 PF04153.18 EDO07574.1 - 0.002 18.2 0.5 0.0032 17.6 0.5 1.3 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family DUF3522 PF12036.8 EDO07575.1 - 0.0034 17.7 0.8 0.0034 17.7 0.8 4.0 2 2 0 3 3 3 1 Protein of unknown function (DUF3522) Phage_holin_3_6 PF07332.11 EDO07576.1 - 0.0061 16.6 0.2 0.0061 16.6 0.2 1.4 2 0 0 2 2 2 1 Putative Actinobacterial Holin-X, holin superfamily III TctB PF07331.11 EDO07576.1 - 0.018 15.3 0.6 0.023 15.0 0.6 1.1 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family OppC_N PF12911.7 EDO07576.1 - 0.046 13.7 0.3 0.046 13.7 0.3 2.2 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C Oxidored_q3 PF00499.20 EDO07576.1 - 0.052 13.3 1.9 0.23 11.2 1.3 1.8 1 1 1 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 SepZ PF06066.11 EDO07576.1 - 0.082 13.1 0.7 0.11 12.7 0.7 1.2 1 0 0 1 1 1 0 SepZ DUF2207 PF09972.9 EDO07576.1 - 0.27 10.0 1.8 0.31 9.8 1.8 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) FeoB_associated PF12669.7 EDO07576.1 - 0.43 11.0 12.9 0.4 11.1 1.5 2.6 3 0 0 3 3 3 0 FeoB-associated Cys-rich membrane protein DUF2768 PF10966.8 EDO07576.1 - 0.71 10.4 7.9 2.3 8.7 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2768) EphA2_TM PF14575.6 EDO07576.1 - 2.1 9.3 6.9 3.1 8.7 2.5 2.2 1 1 1 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF2085 PF09858.9 EDO07577.1 - 0.06 13.8 0.2 0.06 13.8 0.2 3.5 3 2 0 3 3 3 0 Predicted membrane protein (DUF2085) T_cell_tran_alt PF15128.6 EDO07577.1 - 0.28 11.0 5.0 1.7 8.5 0.0 2.9 2 1 0 2 2 2 0 T-cell leukemia translocation-altered DUF2663 PF10864.8 EDO07577.1 - 0.28 11.6 6.4 1 9.8 0.4 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2663) CoA_binding_3 PF13727.6 EDO07577.1 - 2.4 8.1 7.8 0.089 12.8 0.5 2.1 2 0 0 2 2 2 0 CoA-binding domain DUF3671 PF12420.8 EDO07577.1 - 3.8 7.6 12.1 1.6e+02 2.4 9.3 3.3 1 1 1 2 2 2 0 Protein of unknown function VESA1_N PF12785.7 EDO07578.1 - 9.5e-20 71.0 26.5 6.6e-19 68.2 11.3 4.4 2 1 1 3 3 3 2 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO07579.1 - 2.5e-210 699.2 22.4 2.5e-210 699.2 22.4 2.7 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 Baculo_PEP_C PF04513.12 EDO07579.1 - 0.00018 21.5 3.2 0.0004 20.4 1.8 2.3 3 0 0 3 3 3 1 Baculovirus polyhedron envelope protein, PEP, C terminus MnmE_helical PF12631.7 EDO07579.1 - 0.0093 16.2 0.0 0.032 14.4 0.0 2.0 3 0 0 3 3 3 1 MnmE helical domain Spc7 PF08317.11 EDO07579.1 - 0.027 13.3 0.9 0.054 12.4 0.9 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein RRF PF01765.19 EDO07579.1 - 0.11 12.4 0.7 0.22 11.5 0.7 1.4 1 0 0 1 1 1 0 Ribosome recycling factor PEP-utilisers_N PF05524.13 EDO07579.1 - 0.28 11.3 0.9 28 4.9 1.5 2.5 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal COX17 PF05051.13 EDO07581.1 - 5.2e-18 65.1 7.7 6.3e-18 64.9 7.7 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) BCNT PF07572.12 EDO07582.1 - 1.4e-11 44.3 0.9 1.4e-11 44.3 0.9 2.4 2 1 0 2 2 2 1 Bucentaur or craniofacial development SRP9-21 PF05486.12 EDO07582.1 - 0.086 13.2 1.2 10 6.6 0.0 2.4 2 0 0 2 2 2 0 Signal recognition particle 9 kDa protein (SRP9) Pneumo_ncap PF03246.13 EDO07583.1 - 0.013 14.3 0.0 0.016 14.0 0.0 1.1 1 0 0 1 1 1 0 Pneumovirus nucleocapsid protein Polyketide_cyc PF03364.20 EDO07585.1 - 5.9e-06 26.5 0.0 7.2e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport DEAD PF00270.29 EDO07586.1 - 5.5e-49 166.3 0.0 3.9e-48 163.5 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO07586.1 - 7.4e-33 113.2 0.2 1.3e-30 105.9 0.2 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO07586.1 - 4.3e-06 26.8 0.0 1.1e-05 25.5 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 EDO07586.1 - 0.095 11.5 0.1 1 8.1 0.0 2.4 2 1 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 ERCC3_RAD25_C PF16203.5 EDO07586.1 - 0.11 11.7 0.1 0.17 11.0 0.1 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Spt5-NGN PF03439.13 EDO07587.1 - 4.7e-20 71.3 0.0 2.4e-19 69.0 0.0 2.4 2 0 0 2 2 2 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.29 EDO07587.1 - 4.2e-12 45.6 32.7 0.00077 19.3 2.1 7.6 8 0 0 8 8 8 4 KOW motif Spt5_N PF11942.8 EDO07587.1 - 6.1e-06 27.1 13.2 6.1e-06 27.1 13.2 2.3 2 1 0 2 2 2 1 Spt5 transcription elongation factor, acidic N-terminal DUF3912 PF13051.6 EDO07587.1 - 4.1e-05 23.7 6.0 0.43 10.9 0.0 4.8 4 0 0 4 4 4 2 Protein of unknown function (DUF3912) KN17_SH3 PF18131.1 EDO07587.1 - 0.023 14.8 5.3 0.028 14.5 1.4 3.0 2 0 0 2 2 2 0 KN17 SH3-like C-terminal domain YajC PF02699.15 EDO07587.1 - 4.3 7.3 9.7 19 5.2 0.4 4.4 4 1 1 5 5 5 0 Preprotein translocase subunit NIF PF03031.18 EDO07589.1 - 9.6e-22 77.4 0.0 3.8e-21 75.5 0.0 2.1 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase LIG3_BRCT PF16759.5 EDO07589.1 - 0.2 12.0 1.6 0.84 10.0 0.3 2.5 2 0 0 2 2 2 0 DNA ligase 3 BRCT domain DUF5423 PF17461.2 EDO07589.1 - 0.46 9.3 8.5 0.79 8.5 8.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5423) SAP18 PF06487.12 EDO07591.1 - 6.2e-07 29.7 0.0 6.2e-07 29.7 0.0 3.1 2 2 0 2 2 2 1 Sin3 associated polypeptide p18 (SAP18) Sld5 PF05916.11 EDO07592.1 - 1.2e-14 54.6 0.3 3.7e-14 53.1 0.1 1.9 2 0 0 2 2 2 1 GINS complex protein Ribosomal_S8e PF01201.22 EDO07593.1 - 1.5e-48 164.4 10.1 3.1e-48 163.4 10.1 1.5 1 1 0 1 1 1 1 Ribosomal protein S8e LMBR1 PF04791.16 EDO07593.1 - 0.042 12.8 1.3 0.047 12.6 1.3 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein GvpK PF05121.12 EDO07593.1 - 0.12 12.4 0.3 14 5.8 0.2 2.3 2 0 0 2 2 2 0 Gas vesicle protein K Peptidase_S24 PF00717.23 EDO07594.1 - 1.2e-10 41.1 0.1 2.1e-10 40.4 0.1 1.4 1 0 0 1 1 1 1 Peptidase S24-like CPW_WPC PF09717.10 EDO07595.1 - 1.1e-46 157.6 32.2 7.9e-15 55.6 1.3 5.5 5 1 0 5 5 5 5 Plasmodium falciparum domain of unknown function (CPW_WPC) NPCBM_assoc PF10633.9 EDO07595.1 - 0.16 12.3 0.1 0.61 10.4 0.0 2.0 2 0 0 2 2 2 0 NPCBM-associated, NEW3 domain of alpha-galactosidase Bac_surface_Ag PF01103.23 EDO07597.1 - 1.5e-13 50.9 0.1 2.1e-13 50.5 0.1 1.2 1 0 0 1 1 1 1 Surface antigen Proteasome PF00227.26 EDO07598.1 - 5.1e-56 189.2 0.0 8.2e-56 188.5 0.0 1.3 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.9 EDO07598.1 - 1.9e-08 33.8 0.2 5.2e-08 32.4 0.0 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Sipho_Gp157 PF05565.11 EDO07598.1 - 0.084 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Siphovirus Gp157 MACPF PF01823.19 EDO07599.1 - 5.1e-23 82.3 0.1 3.6e-22 79.5 0.1 2.0 1 1 0 1 1 1 1 MAC/Perforin domain RNA_pol_A_bac PF01000.26 EDO07602.1 - 0.0089 16.4 1.7 3.2 8.1 0.1 2.9 3 0 0 3 3 3 2 RNA polymerase Rpb3/RpoA insert domain WAPL PF07814.13 EDO07602.1 - 0.077 11.8 0.2 0.17 10.6 0.2 1.6 1 0 0 1 1 1 0 Wings apart-like protein regulation of heterochromatin GTP_EFTU PF00009.27 EDO07603.1 - 3.6e-56 189.8 0.0 5.5e-56 189.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EDO07603.1 - 1.8e-31 108.4 0.1 8.1e-31 106.3 0.0 2.2 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_II PF14492.6 EDO07603.1 - 1.2e-29 102.2 0.1 2.3e-29 101.3 0.1 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EDO07603.1 - 3.9e-25 87.7 0.1 1e-24 86.4 0.1 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EDO07603.1 - 2e-10 40.9 0.0 5.5e-10 39.5 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EDO07603.1 - 4.5e-05 23.3 0.0 0.00011 22.1 0.0 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain AvrPtoB_bdg PF16847.5 EDO07603.1 - 0.0056 17.1 0.0 0.045 14.2 0.0 2.4 2 0 0 2 2 2 1 Avirulence AvrPtoB, BAK1-binding domain MMR_HSR1 PF01926.23 EDO07603.1 - 0.04 14.0 0.0 0.084 13.0 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF1754 PF08555.10 EDO07605.1 - 4.3e-10 40.3 0.3 4.3e-10 40.3 0.3 3.2 2 1 1 3 3 3 1 Eukaryotic family of unknown function (DUF1754) DUF1604 PF07713.13 EDO07605.1 - 6.5e-07 29.1 1.6 1.7e-06 27.7 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1604) TCTP PF00838.17 EDO07605.1 - 0.00026 21.4 5.1 0.00026 21.4 5.1 2.2 2 1 0 2 2 2 1 Translationally controlled tumour protein Synaptobrevin PF00957.21 EDO07605.1 - 0.011 15.5 2.1 0.034 13.9 2.1 1.9 1 0 0 1 1 1 0 Synaptobrevin LtuB PF17455.2 EDO07605.1 - 3 8.5 7.6 7 7.3 1.9 2.7 2 1 0 2 2 2 0 Late transcription unit B C2-set PF05790.15 EDO07606.1 - 0.11 12.7 0.1 0.75 10.0 0.1 2.1 2 0 0 2 2 2 0 Immunoglobulin C2-set domain UbiA PF01040.18 EDO07607.1 - 8.2e-44 149.8 9.7 1.1e-43 149.3 9.7 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family MACPF PF01823.19 EDO07608.1 - 7.2e-90 300.7 20.9 3.4e-32 112.2 0.6 3.3 3 0 0 3 3 3 3 MAC/Perforin domain CPSase_sm_chain PF00988.22 EDO07608.1 - 0.079 12.8 0.0 0.71 9.7 0.0 2.5 3 0 0 3 3 3 0 Carbamoyl-phosphate synthase small chain, CPSase domain OHA PF14418.6 EDO07609.1 - 2.6e-24 84.8 0.0 7.6e-24 83.3 0.0 1.9 1 0 0 1 1 1 1 OST-HTH Associated domain OST-HTH PF12872.7 EDO07609.1 - 1.1e-05 25.2 0.1 3.5e-05 23.5 0.1 1.8 1 0 0 1 1 1 1 OST-HTH/LOTUS domain Hydrolase_3 PF08282.12 EDO07609.1 - 0.8 9.4 2.5 2 8.1 2.5 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase GTP1_OBG PF01018.22 EDO07610.1 - 4.4e-26 91.3 0.2 6e-26 90.9 0.2 1.2 1 0 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.23 EDO07610.1 - 8.3e-21 74.2 0.0 1.2e-20 73.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDO07610.1 - 6.6e-13 48.5 0.0 1.4e-12 47.4 0.0 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.21 EDO07610.1 - 1.8e-07 30.8 0.0 2.6e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDO07610.1 - 7.5e-06 25.6 0.1 0.0015 18.1 0.0 2.2 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain MeaB PF03308.16 EDO07610.1 - 9.3e-05 21.5 0.1 0.29 10.1 0.0 2.1 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB SRPRB PF09439.10 EDO07610.1 - 0.00017 21.1 0.0 0.00024 20.6 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit NOG1 PF06858.14 EDO07610.1 - 0.03 14.1 0.0 0.084 12.7 0.0 1.8 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) ATP_bind_1 PF03029.17 EDO07610.1 - 0.034 13.9 0.0 0.89 9.3 0.0 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Roc PF08477.13 EDO07610.1 - 0.059 13.6 0.0 0.11 12.8 0.0 1.4 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EDO07610.1 - 0.073 12.4 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_18 PF13238.6 EDO07610.1 - 0.086 13.4 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 EDO07610.1 - 0.2 11.7 0.1 15 5.6 0.0 2.3 1 1 1 2 2 2 0 Dynamin family dCMP_cyt_deam_1 PF00383.23 EDO07612.1 - 2.9e-16 59.2 0.4 1.8e-15 56.7 0.3 1.9 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EDO07612.1 - 1.6e-14 53.8 0.8 3.5e-14 52.7 0.8 1.5 1 1 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 EDO07612.1 - 0.086 12.9 1.3 0.21 11.7 1.3 1.6 1 1 0 1 1 1 0 Bd3614-like deaminase Snf7 PF03357.21 EDO07613.1 - 2.2e-18 66.4 0.4 2.8e-18 66.1 0.4 1.0 1 0 0 1 1 1 1 Snf7 Ins_beta PF03488.14 EDO07613.1 - 0.088 12.8 0.7 1.4 9.0 0.0 2.5 2 0 0 2 2 2 0 Nematode insulin-related peptide beta type Resolvase PF00239.21 EDO07613.1 - 0.17 12.0 0.6 0.26 11.4 0.6 1.3 1 0 0 1 1 1 0 Resolvase, N terminal domain DEAD PF00270.29 EDO07614.1 - 3.1e-35 121.5 0.2 8.6e-35 120.1 0.2 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO07614.1 - 3.5e-21 75.6 0.1 2e-19 70.0 0.0 3.4 4 0 0 4 4 4 1 Helicase conserved C-terminal domain YqzH PF14164.6 EDO07614.1 - 0.13 12.3 1.7 0.39 10.8 0.2 2.6 3 0 0 3 3 3 0 YqzH-like protein POP1 PF06978.11 EDO07615.1 - 4.7e-35 121.4 18.5 5.7e-18 65.7 4.8 3.1 2 1 1 3 3 3 2 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 EDO07615.1 - 4.3e-11 43.0 0.0 1e-10 41.8 0.0 1.7 1 0 0 1 1 1 1 POPLD (NUC188) domain GCV_T PF01571.21 EDO07615.1 - 0.0057 16.1 0.0 3.7 6.8 0.0 3.0 2 1 0 2 2 2 2 Aminomethyltransferase folate-binding domain eIF-3_zeta PF05091.12 EDO07617.1 - 1e-155 519.7 0.0 1.3e-155 519.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Patatin PF01734.22 EDO07618.1 - 1.5e-24 87.3 0.1 4.1e-24 85.9 0.1 1.8 1 0 0 1 1 1 1 Patatin-like phospholipase DUF2090 PF09863.9 EDO07618.1 - 0.0021 17.2 0.2 0.084 11.9 0.1 2.2 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2090) Halogen_Hydrol PF10112.9 EDO07618.1 - 0.076 13.0 1.3 0.26 11.3 0.9 2.0 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein zf-HC5HC2H_2 PF13832.6 EDO07619.1 - 1.6e-17 63.6 29.0 7.7e-11 42.1 9.4 4.6 3 1 0 3 3 3 2 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EDO07619.1 - 2.2e-12 47.0 24.0 6.3e-08 32.8 9.8 5.5 5 0 0 5 5 5 2 PHD-like zinc-binding domain PHD PF00628.29 EDO07619.1 - 3.3e-05 23.7 5.3 3.3e-05 23.7 5.3 8.8 7 2 1 8 8 8 2 PHD-finger Rhomboid PF01694.22 EDO07620.1 - 4.7e-23 81.8 11.9 6.6e-15 55.4 1.8 2.7 3 0 0 3 3 3 2 Rhomboid family DUF1751 PF08551.10 EDO07620.1 - 0.17 12.5 0.1 0.17 12.5 0.1 2.4 3 0 0 3 3 3 0 Eukaryotic integral membrane protein (DUF1751) Ribosomal_L15e PF00827.17 EDO07622.1 - 4.4e-90 300.5 11.2 5.1e-90 300.3 11.2 1.0 1 0 0 1 1 1 1 Ribosomal L15 Hepatitis_core PF00906.20 EDO07622.1 - 3.1 7.3 13.4 0.35 10.4 0.3 2.1 2 0 0 2 2 2 0 Hepatitis core antigen Clat_adaptor_s PF01217.20 EDO07623.1 - 2.2e-09 37.4 0.1 9.2e-09 35.4 0.1 1.8 1 1 0 1 1 1 1 Clathrin adaptor complex small chain AP2 PF00847.20 EDO07624.1 - 8.6e-18 64.3 2.0 2e-17 63.1 2.0 1.7 1 0 0 1 1 1 1 AP2 domain DUF3110 PF11360.8 EDO07624.1 - 0.083 13.1 0.2 0.94 9.7 0.2 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3110) Mqo PF06039.15 EDO07625.1 - 1e-21 77.1 0.0 2.4e-21 75.9 0.0 1.5 1 1 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) DAO PF01266.24 EDO07625.1 - 1.4e-17 64.4 0.0 1.9e-17 63.9 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EDO07625.1 - 1.8e-06 27.4 0.0 1.7e-05 24.2 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EDO07625.1 - 0.0074 15.5 0.0 0.67 9.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDO07625.1 - 0.083 13.1 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Peptidase_M4_C PF02868.15 EDO07625.1 - 0.12 12.2 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Thermolysin metallopeptidase, alpha-helical domain Rootletin PF15035.6 EDO07627.1 - 0.041 13.9 0.1 0.95 9.5 0.3 2.0 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion NUDIX PF00293.28 EDO07629.1 - 2.6e-08 34.0 0.0 4.7e-08 33.1 0.0 1.4 1 1 0 1 1 1 1 NUDIX domain Zip PF02535.22 EDO07630.1 - 8.7e-37 127.1 6.5 1.4e-36 126.4 6.5 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter NUDIX PF00293.28 EDO07631.1 - 1.1e-07 31.9 0.0 1.9e-07 31.2 0.0 1.3 1 1 0 1 1 1 1 NUDIX domain HD_assoc PF13286.6 EDO07632.1 - 0.09 13.3 1.0 2.6 8.7 0.0 3.0 2 0 0 2 2 2 0 Phosphohydrolase-associated domain PGM_PMM_I PF02878.16 EDO07633.1 - 1.7e-15 56.9 0.1 1.7e-08 34.2 0.0 2.4 1 1 1 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 EDO07633.1 - 2.9e-09 37.0 0.1 1.3e-08 34.9 0.0 2.0 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 EDO07633.1 - 0.0038 17.8 0.0 0.013 16.2 0.0 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II VESA1_N PF12785.7 EDO07634.1 - 1.4e-28 100.1 15.9 5.8e-13 48.6 0.1 3.5 2 2 1 3 3 3 3 Variant erythrocyte surface antigen-1 T3SSipB PF16535.5 EDO07634.1 - 0.07 13.6 0.8 0.14 12.6 0.1 1.8 2 0 0 2 2 2 0 Type III cell invasion protein SipB F-box-like_2 PF13013.6 EDO07636.1 - 9e-05 22.4 0.2 0.00016 21.6 0.2 1.4 1 0 0 1 1 1 1 F-box-like domain SPATA3 PF15662.5 EDO07636.1 - 0.11 13.2 0.3 0.15 12.7 0.3 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated protein 3 family DUF2076 PF09849.9 EDO07636.1 - 0.15 12.1 0.2 0.19 11.8 0.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) VESA1_N PF12785.7 EDO07637.1 - 6.4e-19 68.3 9.9 1.2e-10 40.9 0.1 4.3 3 1 2 5 5 5 3 Variant erythrocyte surface antigen-1 Med3 PF11593.8 EDO07637.1 - 0.44 9.7 12.2 0.65 9.1 9.4 2.1 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal SUIM_assoc PF16619.5 EDO07637.1 - 4.1 7.5 12.5 11 6.2 12.5 1.7 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 VESA1_N PF12785.7 EDO07638.1 - 1.5e-190 634.0 20.9 9.2e-127 423.8 1.2 3.6 3 1 1 4 4 3 2 Variant erythrocyte surface antigen-1 MnmE_helical PF12631.7 EDO07638.1 - 0.0041 17.3 0.0 0.015 15.5 0.0 2.0 2 0 0 2 2 2 1 MnmE helical domain EzrA PF06160.12 EDO07638.1 - 0.034 12.3 8.6 0.051 11.7 8.6 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA DUF2564 PF10819.8 EDO07638.1 - 0.14 12.5 1.9 0.32 11.4 1.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2564) Exonuc_VII_L PF02601.15 EDO07638.1 - 0.17 11.5 0.9 0.29 10.7 0.9 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit YlbD_coat PF14071.6 EDO07638.1 - 0.17 12.1 5.7 15 5.8 2.2 3.9 3 1 1 4 4 4 0 Putative coat protein YkyA PF10368.9 EDO07638.1 - 0.25 11.0 9.9 0.52 10.0 9.9 1.5 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein Fez1 PF06818.15 EDO07638.1 - 0.26 11.7 8.7 0.56 10.6 7.8 2.0 2 0 0 2 2 2 0 Fez1 SKA2 PF16740.5 EDO07638.1 - 0.26 11.1 6.1 0.45 10.3 0.0 3.0 2 1 1 3 3 2 0 Spindle and kinetochore-associated protein 2 Sigma70_ner PF04546.13 EDO07638.1 - 0.27 11.1 9.8 0.59 10.0 9.8 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region Baculo_PEP_C PF04513.12 EDO07638.1 - 0.28 11.2 3.4 0.85 9.7 0.6 3.1 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus HemX PF04375.14 EDO07638.1 - 0.3 10.3 2.1 2.5 7.3 3.6 1.7 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Spc7 PF08317.11 EDO07638.1 - 0.36 9.7 13.4 0.54 9.1 12.5 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein RRF PF01765.19 EDO07638.1 - 0.43 10.5 8.4 0.91 9.5 8.4 1.5 1 0 0 1 1 1 0 Ribosome recycling factor CC2-LZ PF16516.5 EDO07638.1 - 0.55 10.6 8.5 1.1 9.7 7.9 1.8 1 1 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator HAUS-augmin3 PF14932.6 EDO07638.1 - 0.61 9.6 5.7 1.2 8.7 5.7 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 AAA_23 PF13476.6 EDO07638.1 - 1 9.8 8.7 1.2 9.6 7.2 1.8 2 0 0 2 2 1 0 AAA domain DivIVA PF05103.13 EDO07638.1 - 1.2 9.3 8.1 2.6 8.1 8.1 1.6 1 0 0 1 1 1 0 DivIVA protein FliJ PF02050.16 EDO07638.1 - 1.3 9.2 7.9 1.9 8.7 4.3 2.8 3 0 0 3 3 3 0 Flagellar FliJ protein Sec8_exocyst PF04048.14 EDO07638.1 - 2.9 7.8 5.2 1.1 9.1 1.6 2.1 2 0 0 2 2 1 0 Sec8 exocyst complex component specific domain zinc_ribbon_9 PF14369.6 EDO07638.1 - 3.2 8.1 7.3 16 5.9 7.3 2.2 1 0 0 1 1 1 0 zinc-ribbon FlgN PF05130.12 EDO07638.1 - 3.8 8.0 9.5 9.8 6.7 9.5 1.6 1 0 0 1 1 1 0 FlgN protein Mt_ATP-synt_D PF05873.12 EDO07638.1 - 6.3 6.6 8.8 1.8 8.4 4.4 2.3 1 1 2 3 3 3 0 ATP synthase D chain, mitochondrial (ATP5H) DUF1664 PF07889.12 EDO07638.1 - 8.6 6.4 8.8 13 5.8 5.1 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) SKA2 PF16740.5 EDO07639.1 - 0.16 11.7 1.1 2 8.2 0.1 2.5 2 1 0 2 2 2 0 Spindle and kinetochore-associated protein 2 CPBP PF02517.16 EDO07641.1 - 9.2e-12 45.2 3.7 9.2e-12 45.2 3.7 2.5 2 1 0 2 2 2 1 CPBP intramembrane metalloprotease CUE PF02845.16 EDO07642.1 - 0.22 11.3 1.4 0.41 10.4 0.1 2.1 2 0 0 2 2 2 0 CUE domain Lyase_1 PF00206.20 EDO07643.1 - 2.2e-40 139.0 0.0 3e-40 138.6 0.0 1.1 1 0 0 1 1 1 1 Lyase ASL_C PF08328.11 EDO07643.1 - 1.9e-34 118.2 0.0 3.4e-34 117.4 0.0 1.4 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminal Ribosomal_S9 PF00380.19 EDO07644.1 - 4.9e-25 88.4 0.0 8.3e-25 87.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Ras PF00071.22 EDO07645.1 - 8.2e-62 207.6 2.5 9.9e-62 207.3 2.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO07645.1 - 2.7e-34 118.0 0.7 4.9e-34 117.1 0.7 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO07645.1 - 5.7e-18 65.0 0.3 7.4e-18 64.6 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDO07645.1 - 7.8e-06 25.4 0.3 1.2e-05 24.8 0.3 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EDO07645.1 - 1.1e-05 25.4 1.4 0.076 12.9 0.1 2.2 1 1 1 2 2 2 2 RsgA GTPase SRPRB PF09439.10 EDO07645.1 - 1.4e-05 24.6 0.4 1.9e-05 24.2 0.4 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EDO07645.1 - 2e-05 24.7 0.3 3.2e-05 24.0 0.3 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EDO07645.1 - 9e-05 22.4 0.2 0.00088 19.1 0.0 1.9 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 EDO07645.1 - 9.6e-05 22.0 1.3 0.0035 16.9 1.2 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EDO07645.1 - 0.009 16.3 0.2 0.078 13.2 0.0 2.3 2 2 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EDO07645.1 - 0.011 16.3 0.8 0.022 15.2 0.8 1.8 1 1 0 1 1 1 0 ABC transporter AAA_23 PF13476.6 EDO07645.1 - 0.016 15.7 0.6 0.024 15.1 0.6 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EDO07645.1 - 0.035 13.9 0.1 0.084 12.6 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain CPT PF07931.12 EDO07645.1 - 0.036 13.9 0.1 0.084 12.7 0.0 1.6 1 1 1 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_24 PF13479.6 EDO07645.1 - 0.045 13.5 0.8 0.14 11.8 0.1 2.1 2 2 1 3 3 3 0 AAA domain AAA_16 PF13191.6 EDO07645.1 - 0.045 14.1 0.1 0.078 13.4 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 EDO07645.1 - 0.051 12.8 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Septin NACHT PF05729.12 EDO07645.1 - 0.083 12.8 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 NACHT domain Homez PF11569.8 EDO07646.1 - 0.1 12.1 0.0 0.25 10.8 0.0 1.6 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Cnn_1N PF07989.11 EDO07648.1 - 0.029 14.5 1.0 0.065 13.4 1.0 1.6 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 HupH_C PF04809.13 EDO07648.1 - 0.055 13.2 1.8 0.59 9.9 0.1 2.4 2 1 0 2 2 2 0 HupH hydrogenase expression protein, C-terminal conserved region bZIP_2 PF07716.15 EDO07648.1 - 0.33 11.1 4.3 0.79 9.8 4.3 1.6 1 0 0 1 1 1 0 Basic region leucine zipper ArsA_HSP20 PF17886.1 EDO07651.1 - 0.12 12.0 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 HSP20-like domain found in ArsA TORC_N PF12884.7 EDO07651.1 - 0.13 13.1 0.0 0.48 11.2 0.0 2.0 1 0 0 1 1 1 0 Transducer of regulated CREB activity, N terminus NUC153 PF08159.12 EDO07652.1 - 1.4e-05 24.8 1.2 1.4e-05 24.8 1.2 3.5 3 0 0 3 3 3 2 NUC153 domain Spectrin PF00435.21 EDO07654.1 - 0.0012 19.3 6.7 0.0012 19.3 6.7 7.2 2 1 7 9 9 9 1 Spectrin repeat DUF5486 PF17588.2 EDO07654.1 - 0.0045 16.8 7.8 0.03 14.2 0.3 3.4 3 0 0 3 3 3 2 Family of unknown function (DUF5486) DUF3552 PF12072.8 EDO07654.1 - 0.0056 16.1 116.2 0.025 14.0 15.3 5.4 1 1 3 5 5 5 3 Domain of unknown function (DUF3552) Spc7 PF08317.11 EDO07654.1 - 0.39 9.6 111.0 0.059 12.3 36.4 5.0 2 2 3 5 5 5 0 Spc7 kinetochore protein Fez1 PF06818.15 EDO07654.1 - 0.78 10.2 101.7 0.11 13.0 33.5 4.6 1 1 3 4 4 4 0 Fez1 Cpn60_TCP1 PF00118.24 EDO07655.1 - 8.6e-141 469.9 1.1 9.9e-141 469.7 1.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family TFIIA PF03153.13 EDO07656.1 - 2 8.3 4.9 2 8.3 4.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CBFB_NFYA PF02045.15 EDO07659.1 - 0.0003 21.3 0.9 0.00051 20.6 0.9 1.3 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B DAO PF01266.24 EDO07660.1 - 1.1e-40 140.3 0.0 1.8e-40 139.6 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 EDO07660.1 - 1.2e-35 122.1 0.0 3.6e-35 120.6 0.0 1.8 2 0 0 2 2 2 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 EDO07660.1 - 1.1e-10 41.1 1.4 8.6e-06 25.1 0.5 2.2 2 0 0 2 2 2 2 FAD binding domain FAD_binding_3 PF01494.19 EDO07660.1 - 1e-07 31.6 0.0 0.0053 16.1 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.7 EDO07660.1 - 6.4e-07 29.1 2.7 0.00023 20.7 0.9 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDO07660.1 - 0.0011 18.3 0.4 0.0056 16.0 0.4 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EDO07660.1 - 0.0019 17.3 1.0 0.022 13.9 0.3 2.0 2 0 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EDO07660.1 - 0.0027 17.9 0.2 0.0094 16.2 0.2 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EDO07660.1 - 0.077 12.2 0.0 0.17 11.1 0.0 1.5 1 0 0 1 1 1 0 Thi4 family zf-Mss51 PF13824.6 EDO07660.1 - 0.12 12.4 0.5 0.33 11.1 0.0 1.9 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 GvpD PF07088.11 EDO07660.1 - 0.2 10.3 0.0 0.44 9.1 0.0 1.5 2 0 0 2 2 2 0 GvpD gas vesicle protein STALD PF18185.1 EDO07661.1 - 0.15 11.4 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Sir2- and TIR-associating SLOG family Sec63 PF02889.16 EDO07662.1 - 1.8e-136 453.4 0.0 6.8e-82 274.5 0.0 2.5 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EDO07662.1 - 1.6e-36 125.7 0.3 6.8e-23 81.3 0.0 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 EDO07662.1 - 1.8e-32 111.8 0.1 4.5e-32 110.5 0.1 1.7 1 0 0 1 1 1 1 N-terminal helicase PWI domain ResIII PF04851.15 EDO07662.1 - 9.2e-10 38.8 0.0 1.7e-08 34.6 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDO07662.1 - 2.6e-08 34.2 0.0 5.9e-07 29.8 0.0 3.4 2 1 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EDO07662.1 - 0.00065 20.0 0.1 0.0051 17.1 0.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EDO07662.1 - 0.078 12.6 0.0 0.38 10.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain RNA_pol_Rpb2_6 PF00562.28 EDO07663.1 - 6.2e-116 387.7 0.1 9.5e-116 387.1 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EDO07663.1 - 8.6e-42 142.9 0.0 1.4e-41 142.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 EDO07663.1 - 1.4e-32 111.9 0.1 3.7e-32 110.6 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 EDO07663.1 - 3e-24 85.1 1.1 6.2e-24 84.1 1.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_2 PF04561.14 EDO07663.1 - 7.9e-22 77.8 0.0 1.4e-21 77.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.16 EDO07663.1 - 8e-18 64.4 0.1 2e-17 63.1 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EDO07663.1 - 4.4e-08 33.6 0.0 1.9e-07 31.5 0.0 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Ribosom_S12_S23 PF00164.25 EDO07664.1 - 3.2e-49 165.3 0.5 4.1e-49 164.9 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Ribosomal_L30_N PF08079.12 EDO07665.1 - 3.5e-17 62.4 11.8 5.3e-17 61.8 11.8 1.3 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 EDO07665.1 - 3.3e-16 58.9 2.8 1.3e-15 57.0 2.7 2.0 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e CH PF00307.31 EDO07666.1 - 5e-11 42.7 3.6 7.5e-11 42.2 0.0 2.7 2 1 1 3 3 3 1 Calponin homology (CH) domain EB1 PF03271.17 EDO07666.1 - 1.3e-09 38.1 0.2 4.2e-09 36.5 0.2 1.9 1 0 0 1 1 1 1 EB1-like C-terminal motif Filament PF00038.21 EDO07666.1 - 5.2e-05 23.0 14.5 8.8e-05 22.2 14.5 1.3 1 0 0 1 1 1 1 Intermediate filament protein FPP PF05911.11 EDO07666.1 - 0.00036 18.9 10.7 0.00047 18.5 10.7 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil DUF812 PF05667.11 EDO07666.1 - 0.00044 19.3 10.8 0.0006 18.8 10.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Macoilin PF09726.9 EDO07666.1 - 0.00087 18.0 9.9 0.001 17.7 9.9 1.1 1 0 0 1 1 1 1 Macoilin family PspA_IM30 PF04012.12 EDO07666.1 - 0.002 17.7 12.0 0.0033 17.0 11.5 1.6 1 1 0 1 1 1 1 PspA/IM30 family HMMR_N PF15905.5 EDO07666.1 - 0.0027 17.2 18.8 0.011 15.2 16.2 2.0 1 1 1 2 2 2 2 Hyaluronan mediated motility receptor N-terminal DUF3450 PF11932.8 EDO07666.1 - 0.0028 17.0 14.2 0.0046 16.3 14.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) CENP-F_leu_zip PF10473.9 EDO07666.1 - 0.0031 17.5 11.0 0.0048 16.9 11.0 1.4 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 End3 PF12761.7 EDO07666.1 - 0.0058 16.8 7.4 0.0093 16.2 7.4 1.3 1 0 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 DUF641 PF04859.12 EDO07666.1 - 0.013 15.8 12.7 0.19 12.1 4.2 2.4 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) ADIP PF11559.8 EDO07666.1 - 0.019 15.1 18.2 0.039 14.1 14.8 2.7 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding APG6_N PF17675.1 EDO07666.1 - 0.021 15.4 11.1 0.031 14.8 11.1 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region TolA_bind_tri PF16331.5 EDO07666.1 - 0.021 14.9 10.2 0.1 12.7 9.9 2.3 2 1 1 3 3 2 0 TolA binding protein trimerisation Fungal_TACC PF12709.7 EDO07666.1 - 0.027 14.9 18.4 0.067 13.6 4.9 3.9 2 1 1 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins AAA_23 PF13476.6 EDO07666.1 - 0.036 14.6 14.2 0.058 13.9 14.2 1.3 1 0 0 1 1 1 0 AAA domain Spc7 PF08317.11 EDO07666.1 - 0.041 12.8 17.9 0.073 11.9 16.4 1.7 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF16 PF01519.16 EDO07666.1 - 0.042 14.4 17.7 0.3 11.6 4.9 2.5 1 1 1 2 2 2 0 Protein of unknown function DUF16 WEMBL PF05701.11 EDO07666.1 - 0.046 12.4 16.1 0.022 13.4 8.0 2.1 1 1 1 2 2 2 0 Weak chloroplast movement under blue light HIP1_clath_bdg PF16515.5 EDO07666.1 - 0.049 14.2 13.1 0.24 12.0 6.5 2.4 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Golgin_A5 PF09787.9 EDO07666.1 - 0.051 13.0 12.1 0.091 12.2 12.1 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 RRP36 PF06102.12 EDO07666.1 - 0.056 13.4 11.8 0.092 12.7 11.8 1.3 1 0 0 1 1 1 0 rRNA biogenesis protein RRP36 Phage_GP20 PF06810.11 EDO07666.1 - 0.066 13.0 23.2 0.027 14.3 12.8 2.8 2 1 1 3 3 3 0 Phage minor structural protein GP20 CAMSAP_CH PF11971.8 EDO07666.1 - 0.079 12.8 0.2 0.39 10.6 0.0 2.1 2 0 0 2 2 2 0 CAMSAP CH domain TPR_MLP1_2 PF07926.12 EDO07666.1 - 0.08 13.0 12.5 0.15 12.1 12.5 1.5 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 EDO07666.1 - 0.1 11.9 9.8 0.16 11.3 9.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) THOC7 PF05615.13 EDO07666.1 - 0.11 12.7 15.5 0.88 9.9 15.5 2.2 1 1 0 1 1 1 0 Tho complex subunit 7 DUF2746 PF10874.8 EDO07666.1 - 0.11 12.9 5.2 3.1 8.3 0.6 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2746) Exonuc_VII_L PF02601.15 EDO07666.1 - 0.12 12.0 6.8 0.19 11.3 6.8 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit FlxA PF14282.6 EDO07666.1 - 0.16 12.0 14.1 0.52 10.3 14.1 1.8 1 0 0 1 1 1 0 FlxA-like protein V_ATPase_I PF01496.19 EDO07666.1 - 0.18 9.7 10.8 0.25 9.2 10.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Atg14 PF10186.9 EDO07666.1 - 0.18 10.8 13.9 0.3 10.1 13.9 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 RPW8 PF05659.11 EDO07666.1 - 0.19 11.4 9.6 0.23 11.1 6.9 2.2 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Fez1 PF06818.15 EDO07666.1 - 0.21 12.0 11.6 0.37 11.2 11.6 1.4 1 0 0 1 1 1 0 Fez1 MCC-bdg_PDZ PF10506.9 EDO07666.1 - 0.21 11.6 4.8 0.11 12.6 0.7 2.4 2 0 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Bap31_Bap29_C PF18035.1 EDO07666.1 - 0.59 10.2 16.4 0.18 11.8 1.8 3.0 1 1 2 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain FliJ PF02050.16 EDO07666.1 - 0.6 10.3 12.7 1.5 9.1 12.7 1.6 1 1 0 1 1 1 0 Flagellar FliJ protein FlaC_arch PF05377.11 EDO07666.1 - 0.85 10.1 12.6 1.2 9.5 2.3 3.6 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) TMPIT PF07851.13 EDO07666.1 - 0.96 8.6 9.3 1.9 7.7 9.3 1.6 1 0 0 1 1 1 0 TMPIT-like protein YlqD PF11068.8 EDO07666.1 - 1.1 9.7 16.4 2.9 8.3 16.0 1.8 1 1 0 1 1 1 0 YlqD protein XhlA PF10779.9 EDO07666.1 - 1.2 9.4 12.5 0.083 13.1 3.3 2.7 1 1 0 2 2 2 0 Haemolysin XhlA DUF4140 PF13600.6 EDO07666.1 - 1.9 9.0 10.6 16 6.0 4.1 2.6 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Fib_alpha PF08702.10 EDO07666.1 - 2.1 8.5 18.2 1.4 9.1 13.1 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family CC2-LZ PF16516.5 EDO07666.1 - 2.2 8.7 16.0 2.1 8.7 7.5 2.3 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF1664 PF07889.12 EDO07666.1 - 2.5 8.1 13.3 0.1 12.6 6.1 2.1 2 1 1 3 3 2 0 Protein of unknown function (DUF1664) DUF745 PF05335.13 EDO07666.1 - 2.6 7.7 11.6 6.3 6.5 2.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF745) DUF2730 PF10805.8 EDO07666.1 - 3.3 7.9 7.5 8.9 6.5 6.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) bZIP_1 PF00170.21 EDO07666.1 - 3.5 7.8 9.9 18 5.5 0.5 3.5 3 1 1 4 4 4 0 bZIP transcription factor ATG16 PF08614.11 EDO07667.1 - 0.00017 21.9 1.6 0.00017 21.9 1.6 2.1 2 1 0 2 2 2 1 Autophagy protein 16 (ATG16) Scaffolding_pro PF11418.8 EDO07667.1 - 0.00058 20.4 0.5 0.026 15.1 0.2 2.3 2 0 0 2 2 2 1 Phi29 scaffolding protein APG6_N PF17675.1 EDO07667.1 - 0.00077 20.0 4.3 0.00084 19.9 2.9 1.7 2 0 0 2 2 2 1 Apg6 coiled-coil region FAM184 PF15665.5 EDO07667.1 - 0.0019 18.1 1.1 0.0038 17.0 1.1 1.4 1 0 0 1 1 1 1 Family with sequence similarity 184, A and B Spc7 PF08317.11 EDO07667.1 - 0.0027 16.6 3.0 0.025 13.5 1.4 2.1 2 0 0 2 2 2 1 Spc7 kinetochore protein Trimer_CC PF08954.11 EDO07667.1 - 0.0049 16.4 1.9 0.015 14.9 0.4 2.3 2 0 0 2 2 2 1 Trimerisation motif Myosin_tail_1 PF01576.19 EDO07667.1 - 0.0072 14.2 0.4 0.0072 14.2 0.4 1.6 2 0 0 2 2 2 1 Myosin tail Jnk-SapK_ap_N PF09744.9 EDO07667.1 - 0.016 15.4 1.5 0.016 15.4 1.5 1.8 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Mod_r PF07200.13 EDO07667.1 - 0.021 15.0 3.8 0.041 14.0 0.5 2.2 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein CALCOCO1 PF07888.11 EDO07667.1 - 0.022 13.7 2.5 0.033 13.1 2.5 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF1192 PF06698.11 EDO07667.1 - 0.022 14.8 9.3 0.055 13.5 1.4 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) BET PF17035.5 EDO07667.1 - 0.024 14.8 0.3 0.58 10.4 0.0 2.5 2 0 0 2 2 2 0 Bromodomain extra-terminal - transcription regulation Fez1 PF06818.15 EDO07667.1 - 0.027 14.9 2.1 0.051 14.0 0.8 1.8 2 0 0 2 2 2 0 Fez1 TMF_TATA_bd PF12325.8 EDO07667.1 - 0.034 14.4 3.9 2.8 8.2 1.9 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DivIC PF04977.15 EDO07667.1 - 0.037 13.8 6.7 0.059 13.1 1.2 2.9 2 1 0 3 3 3 0 Septum formation initiator GIT_CC PF16559.5 EDO07667.1 - 0.038 13.9 3.6 0.43 10.5 0.3 2.9 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor OmpH PF03938.14 EDO07667.1 - 0.052 13.9 5.7 0.35 11.2 1.9 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) FtsX_ECD PF18075.1 EDO07667.1 - 0.054 14.1 0.8 1.4 9.6 0.0 2.5 2 1 0 2 2 2 0 FtsX extracellular domain KxDL PF10241.9 EDO07667.1 - 0.065 13.5 6.6 2.1 8.7 0.3 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein GAS PF13851.6 EDO07667.1 - 0.072 12.4 4.7 0.031 13.6 2.1 1.6 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Syntaxin-6_N PF09177.11 EDO07667.1 - 0.077 13.6 1.4 2.1 9.0 0.8 2.4 2 0 0 2 2 2 0 Syntaxin 6, N-terminal DUF4200 PF13863.6 EDO07667.1 - 0.11 12.9 6.6 0.2 12.1 2.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) TPR_MLP1_2 PF07926.12 EDO07667.1 - 0.12 12.5 7.1 0.18 11.9 4.0 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein HAUS-augmin3 PF14932.6 EDO07667.1 - 0.15 11.6 4.5 0.078 12.5 1.1 1.9 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 CENP-F_leu_zip PF10473.9 EDO07667.1 - 0.15 12.1 2.9 0.087 12.9 1.0 1.6 2 0 0 2 2 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ZapB PF06005.12 EDO07667.1 - 0.16 12.5 9.1 20 5.7 4.5 3.3 2 1 0 2 2 2 0 Cell division protein ZapB zf-C4H2 PF10146.9 EDO07667.1 - 0.16 12.3 2.1 0.19 12.0 1.6 1.4 1 1 0 1 1 1 0 Zinc finger-containing protein KASH_CCD PF14662.6 EDO07667.1 - 0.16 11.8 6.8 3.6 7.4 2.5 2.5 2 1 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH CENP-H PF05837.12 EDO07667.1 - 0.17 12.3 6.2 0.066 13.6 2.5 2.1 2 1 1 3 3 2 0 Centromere protein H (CENP-H) TetR_C_24 PF17932.1 EDO07667.1 - 0.2 12.0 2.2 2.6 8.3 0.3 2.5 3 0 0 3 3 2 0 Tetracyclin repressor-like, C-terminal domain DUF3450 PF11932.8 EDO07667.1 - 0.21 10.9 5.0 0.062 12.6 2.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Prominin PF05478.11 EDO07667.1 - 0.28 9.1 1.7 0.23 9.4 0.5 1.4 2 0 0 2 2 2 0 Prominin TMF_DNA_bd PF12329.8 EDO07667.1 - 0.36 10.8 5.9 5.5 7.1 0.5 3.0 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Nup54 PF13874.6 EDO07667.1 - 0.46 10.6 5.0 0.46 10.6 2.4 1.9 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Swi5 PF07061.11 EDO07667.1 - 0.55 10.3 3.6 3.4 7.8 0.4 2.8 2 1 1 3 3 3 0 Swi5 ADIP PF11559.8 EDO07667.1 - 0.88 9.6 7.9 0.61 10.2 5.0 1.9 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding ABC_tran_CTD PF16326.5 EDO07667.1 - 0.97 9.7 6.5 1.5 9.1 1.0 2.9 2 1 1 3 3 3 0 ABC transporter C-terminal domain Uso1_p115_C PF04871.13 EDO07667.1 - 1.9 8.8 6.2 0.74 10.2 2.6 2.0 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF4140 PF13600.6 EDO07667.1 - 3.3 8.2 7.3 83 3.7 4.5 3.0 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) FAM76 PF16046.5 EDO07667.1 - 3.4 6.9 5.1 2.7 7.3 2.0 1.9 1 1 1 2 2 2 0 FAM76 protein BRE1 PF08647.11 EDO07667.1 - 5.3 7.2 8.4 7.7 6.7 4.4 2.7 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase RRM_1 PF00076.22 EDO07669.1 - 0.00041 20.1 0.0 0.001 18.8 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-Tim10_DDP PF02953.15 EDO07670.1 - 3.1e-13 49.1 0.4 3.9e-13 48.8 0.4 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger MPC PF03650.13 EDO07671.1 - 1.5e-34 118.5 0.1 1.7e-34 118.3 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers WD40 PF00400.32 EDO07672.1 - 2.7e-28 97.6 31.5 3e-07 31.0 0.4 5.9 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO07672.1 - 1e-08 35.4 0.8 0.065 13.5 0.1 4.7 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain zf-C2H2 PF00096.26 EDO07673.1 - 4.2e-21 74.2 31.5 3.4e-05 24.0 0.4 5.5 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDO07673.1 - 7.5e-15 54.4 29.8 0.0031 18.2 0.3 5.6 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDO07673.1 - 1.5e-06 28.3 10.3 0.52 10.7 0.0 4.7 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDO07673.1 - 8.6e-05 22.8 7.4 0.0081 16.5 0.2 4.8 4 0 0 4 4 4 1 Zinc-finger of C2H2 type zf_Hakai PF18408.1 EDO07673.1 - 0.0024 17.5 10.1 0.063 13.0 0.1 3.7 3 0 0 3 3 3 2 C2H2 Hakai zinc finger domain zf_ZIC PF18366.1 EDO07673.1 - 0.0067 16.5 10.6 0.11 12.7 0.1 4.1 4 0 0 4 4 4 1 Zic proteins zinc finger domain zf-H2C2_2 PF13465.6 EDO07673.1 - 0.016 15.7 0.5 0.016 15.7 0.5 6.2 7 0 0 7 7 7 0 Zinc-finger double domain zf-C2H2_8 PF15909.5 EDO07673.1 - 0.06 13.6 15.4 1.9 8.8 4.4 4.3 2 1 2 4 4 4 0 C2H2-type zinc ribbon zf-trcl PF13451.6 EDO07673.1 - 0.094 12.6 1.8 0.23 11.4 1.8 1.6 1 0 0 1 1 1 0 Probable zinc-ribbon domain FOXP-CC PF16159.5 EDO07673.1 - 0.47 11.1 13.5 7.5 7.3 0.1 4.1 3 1 0 4 4 4 0 FOXP coiled-coil domain LSM PF01423.22 EDO07674.1 - 1.3e-17 63.2 0.1 1.6e-17 62.9 0.1 1.1 1 0 0 1 1 1 1 LSM domain Mago-bind PF09282.10 EDO07675.1 - 9.7e-12 44.5 4.8 1.5e-11 43.9 4.8 1.3 1 0 0 1 1 1 1 Mago binding eIF-5_eIF-2B PF01873.17 EDO07676.1 - 4.8e-36 123.2 0.2 1.1e-35 122.0 0.2 1.7 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 EDO07676.1 - 1.1e-06 28.6 0.0 1.1e-06 28.6 0.0 2.0 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Ski_Sno PF02437.17 EDO07676.1 - 0.1 12.3 0.2 0.21 11.3 0.2 1.4 1 0 0 1 1 1 0 SKI/SNO/DAC family Med19 PF10278.9 EDO07676.1 - 0.74 9.7 12.5 1.5 8.7 12.5 1.5 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Ribosomal_L7Ae PF01248.26 EDO07677.1 - 2e-18 65.9 0.4 2.9e-18 65.4 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family HGD-D PF06050.13 EDO07677.1 - 0.0099 15.7 0.0 0.012 15.4 0.0 1.1 1 0 0 1 1 1 1 2-hydroxyglutaryl-CoA dehydratase, D-component Ribosomal_S19e PF01090.19 EDO07678.1 - 2.2e-47 160.2 0.0 2.6e-47 160.0 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e GDI PF00996.18 EDO07679.1 - 7.6e-201 667.3 0.2 8.7e-201 667.1 0.2 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor SH3_14 PF18343.1 EDO07679.1 - 0.08 13.0 0.0 0.31 11.1 0.0 2.1 2 0 0 2 2 2 0 Dda helicase SH3 domain NAD_binding_8 PF13450.6 EDO07679.1 - 0.13 12.5 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DUF3689 PF12463.8 EDO07680.1 - 0.17 11.2 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3689) Ribosomal_S17e PF00833.18 EDO07681.1 - 2.5e-25 88.8 0.0 3.2e-25 88.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal S17 Phlebovirus_G1 PF07243.11 EDO07681.1 - 0.076 11.4 0.5 0.088 11.2 0.5 1.1 1 0 0 1 1 1 0 Phlebovirus glycoprotein G1 DUF3147 PF11345.8 EDO07681.1 - 0.21 11.9 4.2 0.28 11.5 4.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3147) VESA1_N PF12785.7 EDO07682.1 - 2.4e-12 46.6 0.0 2.4e-12 46.6 0.0 2.5 2 0 0 2 2 2 1 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO07683.1 - 3.3e-98 329.6 2.9 4.5e-98 329.2 2.9 1.2 1 0 0 1 1 1 1 Variant erythrocyte surface antigen-1 Borrelia_REV PF03978.13 EDO07683.1 - 0.053 13.5 4.7 0.17 11.8 0.0 2.7 2 1 1 3 3 3 0 Borrelia burgdorferi REV protein Ribosomal_L12 PF00542.19 EDO07683.1 - 8.4 6.8 15.0 2 8.8 4.3 3.2 3 1 0 3 3 3 0 Ribosomal protein L7/L12 C-terminal domain Ribosomal_S17e PF00833.18 EDO07684.1 - 2.5e-25 88.8 0.0 3.2e-25 88.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal S17 Phlebovirus_G1 PF07243.11 EDO07684.1 - 0.076 11.4 0.5 0.088 11.2 0.5 1.1 1 0 0 1 1 1 0 Phlebovirus glycoprotein G1 DUF3147 PF11345.8 EDO07684.1 - 0.21 11.9 4.2 0.28 11.5 4.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3147) ING PF12998.7 EDO07685.1 - 0.0075 16.8 0.3 0.21 12.2 0.1 2.8 1 1 2 3 3 3 1 Inhibitor of growth proteins N-terminal histone-binding WcbI PF18588.1 EDO07687.1 - 0.13 11.9 0.0 0.13 11.9 0.0 1.0 1 0 0 1 1 1 0 Polysaccharide biosynthesis enzyme WcbI DUF4731 PF15875.5 EDO07688.1 - 0.064 13.4 0.6 0.064 13.4 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4731) DUF5453 PF17534.2 EDO07688.1 - 5.3 7.0 11.8 0.12 12.4 3.0 2.4 2 1 0 2 2 2 0 Family of unknown function (DUF5453) VESA1_N PF12785.7 EDO07689.1 - 4.3e-179 596.3 59.2 1.6e-169 564.7 25.8 2.7 2 1 0 2 2 2 2 Variant erythrocyte surface antigen-1 Laminin_II PF06009.12 EDO07689.1 - 0.086 12.9 1.3 0.22 11.5 0.4 2.0 2 0 0 2 2 2 0 Laminin Domain II Borrelia_REV PF03978.13 EDO07689.1 - 0.17 11.9 0.8 0.48 10.4 0.0 2.0 2 0 0 2 2 2 0 Borrelia burgdorferi REV protein Cortex-I_coil PF09304.10 EDO07689.1 - 0.2 11.9 1.5 22 5.3 0.1 2.4 2 0 0 2 2 2 0 Cortexillin I, coiled coil Pex19 PF04614.12 EDO07689.1 - 2.2 8.0 3.6 1.6 8.5 1.8 1.6 2 0 0 2 2 2 0 Pex19 protein family DUF3493 PF11998.8 EDO07690.1 - 0.54 10.5 4.4 0.23 11.6 0.5 2.5 2 0 0 2 2 2 0 Low psii accumulation1 / Rep27 ING PF12998.7 EDO07691.1 - 0.0019 18.7 0.1 0.22 12.1 0.1 2.7 1 1 1 2 2 2 2 Inhibitor of growth proteins N-terminal histone-binding Ribosomal_S17e PF00833.18 EDO07692.1 - 7.8e-59 196.9 1.0 9e-59 196.7 1.0 1.0 1 0 0 1 1 1 1 Ribosomal S17 Met_10 PF02475.16 EDO07693.1 - 1.4e-61 207.7 0.2 1.9e-61 207.3 0.2 1.1 1 0 0 1 1 1 1 Met-10+ like-protein TRM PF02005.16 EDO07693.1 - 0.0052 16.0 0.0 0.0084 15.3 0.0 1.3 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_15 PF09445.10 EDO07693.1 - 0.0054 16.3 0.0 0.014 15.0 0.0 1.6 1 1 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 EDO07693.1 - 0.0074 15.7 0.1 0.53 9.6 0.0 2.6 2 1 1 3 3 3 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 EDO07693.1 - 0.061 13.1 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain VESA1_N PF12785.7 EDO07694.1 - 5.1e-20 71.9 2.5 3.6e-17 62.5 2.5 3.1 1 1 0 1 1 1 1 Variant erythrocyte surface antigen-1 WRKY PF03106.15 EDO07694.1 - 0.33 11.2 2.9 6 7.2 0.3 2.9 2 0 0 2 2 2 0 WRKY DNA -binding domain VESA1_N PF12785.7 EDO07695.1 - 6.2e-185 615.5 22.0 6.2e-185 615.5 22.0 3.7 3 1 0 3 3 3 1 Variant erythrocyte surface antigen-1 DUF1002 PF06207.11 EDO07695.1 - 0.22 11.0 2.3 0.41 10.2 2.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) HOOK PF05622.12 EDO07695.1 - 0.29 9.2 3.3 0.51 8.4 3.3 1.3 1 0 0 1 1 1 0 HOOK protein Plant_vir_prot PF01307.17 EDO07696.1 - 0.77 10.0 4.9 4.9 7.4 0.0 3.6 4 0 0 4 4 4 0 Plant viral movement protein VESA1_N PF12785.7 EDO07697.1 - 7.5e-158 526.2 16.2 1.1e-157 525.7 16.2 1.3 1 0 0 1 1 1 1 Variant erythrocyte surface antigen-1 DUF1375 PF07119.12 EDO07698.1 - 3.5 8.1 10.7 30 5.1 0.2 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1375) F-box-like_2 PF13013.6 EDO07699.1 - 0.0039 17.1 0.1 0.0065 16.4 0.1 1.4 1 0 0 1 1 1 1 F-box-like domain DUF2076 PF09849.9 EDO07699.1 - 0.053 13.6 0.0 0.057 13.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) PMP1_2 PF08114.11 EDO07700.1 - 0.21 11.3 3.8 4.6 7.1 0.0 3.4 2 0 0 2 2 2 0 ATPase proteolipid family DUF3493 PF11998.8 EDO07700.1 - 0.51 10.5 4.2 0.21 11.8 0.3 2.5 2 0 0 2 2 2 0 Low psii accumulation1 / Rep27 ING PF12998.7 EDO07701.1 - 0.00049 20.7 0.6 0.026 15.1 0.2 2.9 1 1 1 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding YkuI_C PF10388.9 EDO07701.1 - 0.014 15.2 0.4 6.4 6.5 0.0 3.0 1 1 1 3 3 3 0 EAL-domain associated signalling protein domain DUF2811 PF10929.8 EDO07701.1 - 0.068 13.4 0.3 55 4.1 0.0 4.4 4 1 1 5 5 5 0 Protein of unknown function (DUF2811) DUF2281 PF10047.9 EDO07701.1 - 0.12 13.1 0.9 1.8 9.3 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2281) Ribosomal_S17e PF00833.18 EDO07702.1 - 7.9e-59 196.9 1.0 9e-59 196.7 1.0 1.0 1 0 0 1 1 1 1 Ribosomal S17 Ribosomal_L28e PF01778.17 EDO07704.1 - 2e-28 99.5 0.2 2e-28 99.5 0.2 1.8 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 EDO07704.1 - 9e-18 64.7 12.6 2.1e-17 63.6 12.6 1.6 1 0 0 1 1 1 1 Mak16 protein C-terminal region RHH_3 PF12651.7 EDO07704.1 - 0.015 15.3 0.5 0.088 12.8 0.1 2.3 2 0 0 2 2 2 0 Ribbon-helix-helix domain Cactin_mid PF10312.9 EDO07704.1 - 0.015 15.0 5.1 0.025 14.3 5.0 1.4 1 1 0 1 1 1 0 Conserved mid region of cactin D123 PF07065.14 EDO07704.1 - 0.043 13.0 1.3 0.049 12.8 0.6 1.3 1 1 0 1 1 1 0 D123 DUF3713 PF12506.8 EDO07704.1 - 0.11 12.8 0.1 0.24 11.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3713) DUF2250 PF10007.9 EDO07704.1 - 0.41 10.8 6.1 0.65 10.2 3.1 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) DUF3523 PF12037.8 EDO07705.1 - 5.6e-59 199.7 40.9 5.6e-59 199.7 40.9 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF3523) AAA PF00004.29 EDO07705.1 - 1.2e-25 90.4 0.0 2.7e-25 89.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EDO07705.1 - 1.4e-05 24.9 0.0 3.4e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDO07705.1 - 1.5e-05 25.5 2.1 0.0042 17.5 0.0 3.3 2 1 1 3 3 3 1 AAA ATPase domain AAA_24 PF13479.6 EDO07705.1 - 0.00088 19.0 0.1 0.0031 17.3 0.1 2.0 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EDO07705.1 - 0.0013 18.1 0.6 0.0061 16.0 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 EDO07705.1 - 0.0015 18.8 7.1 0.05 13.9 0.0 3.3 2 1 1 3 3 3 2 AAA domain AAA_lid_3 PF17862.1 EDO07705.1 - 0.0016 18.2 0.0 0.0058 16.4 0.0 2.0 1 0 0 1 1 1 1 AAA+ lid domain Sigma54_activ_2 PF14532.6 EDO07705.1 - 0.0016 18.5 0.0 0.005 16.9 0.0 1.9 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.14 EDO07705.1 - 0.0025 17.8 0.1 0.018 15.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Zot PF05707.12 EDO07705.1 - 0.0036 17.0 0.1 0.051 13.2 0.0 2.5 1 1 1 2 2 2 1 Zonular occludens toxin (Zot) AAA_14 PF13173.6 EDO07705.1 - 0.004 17.2 0.0 0.02 14.9 0.0 2.2 1 0 0 1 1 1 1 AAA domain P2_Phage_GpR PF06891.11 EDO07705.1 - 0.0053 16.9 4.9 0.013 15.5 4.9 1.7 1 0 0 1 1 1 1 P2 phage tail completion protein R (GpR) IstB_IS21 PF01695.17 EDO07705.1 - 0.012 15.3 0.0 0.037 13.7 0.0 1.8 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.22 EDO07705.1 - 0.02 15.2 0.0 0.059 13.8 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 EDO07705.1 - 0.035 13.6 0.0 0.11 12.0 0.0 1.8 1 0 0 1 1 1 0 P-loop containing dynein motor region TsaE PF02367.17 EDO07705.1 - 0.035 14.1 0.0 0.14 12.1 0.0 2.0 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 EDO07705.1 - 0.048 13.8 0.0 0.048 13.8 0.0 2.9 2 2 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EDO07705.1 - 0.086 12.4 2.9 1.1 8.8 0.1 2.8 2 1 1 3 3 3 0 AAA domain AAA_18 PF13238.6 EDO07705.1 - 0.12 13.0 0.0 0.12 13.0 0.0 3.5 3 2 0 3 3 2 0 AAA domain AAA_11 PF13086.6 EDO07705.1 - 0.75 9.5 0.0 0.75 9.5 0.0 3.3 2 1 1 3 3 3 0 AAA domain TFIIA PF03153.13 EDO07705.1 - 4.8 7.1 20.4 6.8 6.6 20.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ins_P5_2-kin PF06090.12 EDO07706.1 - 4.9e-19 69.0 0.3 5.6e-18 65.5 0.3 2.0 1 1 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase Pkinase PF00069.25 EDO07707.1 - 7.5e-56 189.4 0.0 2.1e-55 187.9 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO07707.1 - 3e-25 89.0 0.0 2e-24 86.3 0.0 2.2 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO07707.1 - 0.022 14.1 0.0 3.4 6.9 0.0 2.4 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.14 EDO07707.1 - 0.028 13.8 0.0 0.051 12.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SRP40_C PF05022.12 EDO07708.1 - 1.9e-21 76.7 5.6 2.6e-21 76.2 4.8 1.6 2 0 0 2 2 2 1 SRP40, C-terminal domain TAF PF02969.17 EDO07709.1 - 8.2e-08 32.3 0.0 1.4e-06 28.4 0.0 3.0 2 0 0 2 2 2 1 TATA box binding protein associated factor (TAF) TAF6_C PF07571.13 EDO07709.1 - 1.4e-07 31.7 0.2 1e-06 29.0 0.0 2.5 2 0 0 2 2 2 1 TAF6 C-terminal HEAT repeat domain Exog_C PF18026.1 EDO07709.1 - 0.056 13.5 0.0 0.19 11.8 0.0 2.0 1 0 0 1 1 1 0 Endo/exonuclease (EXOG) C-terminal domain CTK3 PF12243.8 EDO07709.1 - 0.3 11.1 3.2 1.5 8.8 0.1 2.9 3 0 0 3 3 3 0 CTD kinase subunit gamma CTK3 COMMD1_N PF17221.3 EDO07710.1 - 0.067 13.5 0.4 0.31 11.3 0.1 2.0 2 0 0 2 2 2 0 COMMD1 N-terminal domain PMBR PF09373.10 EDO07710.1 - 0.075 13.2 0.0 0.55 10.5 0.0 2.6 3 0 0 3 3 3 0 Pseudomurein-binding repeat DUF3194 PF11419.8 EDO07710.1 - 0.079 13.3 0.5 1.8 8.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3194) Mitoc_mL59 PF18126.1 EDO07711.1 - 0.00014 22.1 3.6 0.001 19.4 0.1 2.2 2 0 0 2 2 2 2 Mitochondrial ribosomal protein mL59 Ham1p_like PF01725.16 EDO07712.1 - 4.4e-47 160.4 0.0 5e-47 160.2 0.0 1.0 1 0 0 1 1 1 1 Ham1 family PX PF00787.24 EDO07713.1 - 0.00069 19.6 0.4 0.0024 17.8 0.3 2.0 2 0 0 2 2 2 1 PX domain XhlA PF10779.9 EDO07713.1 - 0.76 10.0 8.4 0.29 11.4 0.9 2.8 2 0 0 2 2 2 0 Haemolysin XhlA Syntaxin-6_N PF09177.11 EDO07713.1 - 1.1 9.8 9.9 2.8 8.6 1.4 3.0 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Ints3 PF10189.9 EDO07714.1 - 0.0061 15.9 0.1 0.017 14.4 0.1 1.7 1 0 0 1 1 1 1 Integrator complex subunit 3 RFX5_N PF18326.1 EDO07714.1 - 0.11 12.3 0.0 0.27 11.0 0.0 1.6 1 0 0 1 1 1 0 RFX5 N-terminal domain Ribosomal_S3Ae PF01015.18 EDO07715.1 - 2.5e-85 285.1 1.7 3.1e-85 284.8 1.7 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family TMA7 PF09072.10 EDO07716.1 - 1.5e-09 38.6 13.6 2.2e-09 38.0 13.6 1.3 1 1 0 1 1 1 1 Translation machinery associated TMA7 GTP_EFTU PF00009.27 EDO07717.1 - 9.2e-58 195.0 0.0 1.3e-57 194.5 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EDO07717.1 - 3.4e-21 75.7 0.0 5.6e-21 74.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EDO07717.1 - 1.5e-15 57.3 2.7 3.3e-15 56.2 2.7 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDO07717.1 - 9.8e-06 25.6 0.0 1.6e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 EDO07717.1 - 0.0077 15.8 0.1 0.058 13.0 0.0 2.2 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 EDO07717.1 - 0.048 13.6 0.0 0.1 12.5 0.0 1.5 2 0 0 2 2 2 0 RsgA GTPase Polyoma_lg_T_C PF06431.11 EDO07717.1 - 0.18 10.7 0.0 5.7 5.7 0.0 2.1 2 0 0 2 2 2 0 Polyomavirus large T antigen C-terminus ATP_bind_1 PF03029.17 EDO07717.1 - 0.2 11.4 4.9 0.62 9.8 0.0 2.8 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Topoisom_bac PF01131.20 EDO07718.1 - 8.9e-108 360.9 0.0 1.1e-107 360.7 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 EDO07718.1 - 4.2e-16 59.1 0.0 1.7e-15 57.1 0.0 2.1 2 0 0 2 2 2 1 Toprim domain Phage_FRD3 PF05798.11 EDO07718.1 - 0.046 14.0 0.1 2 8.7 0.1 2.6 2 0 0 2 2 2 0 Bacteriophage FRD3 protein RRM_1 PF00076.22 EDO07719.1 - 3.2e-36 123.0 0.3 2.1e-14 53.1 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDO07719.1 - 0.00019 21.2 0.0 0.55 10.1 0.0 3.1 3 0 0 3 3 3 2 Occluded RNA-recognition motif DUF1866 PF08952.11 EDO07719.1 - 0.0009 19.1 0.1 0.058 13.2 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1866) RRM_5 PF13893.6 EDO07719.1 - 0.0071 15.9 0.1 0.86 9.2 0.0 2.9 2 1 1 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 EDO07719.1 - 0.0099 17.0 2.5 0.041 15.0 0.5 2.8 2 1 0 2 2 2 1 linker between RRM2 and RRM3 domains in RBM39 protein DUF3707 PF12499.8 EDO07719.1 - 0.019 15.5 0.2 5.9 7.5 0.0 2.3 2 0 0 2 2 2 0 Pherophorin Arc_PepC_II PF06847.11 EDO07719.1 - 0.086 13.4 0.0 0.37 11.3 0.0 2.1 1 0 0 1 1 1 0 Archaeal Peptidase A24 C-terminus Type II DUF272 PF03312.15 EDO07719.1 - 0.099 12.9 0.1 8.2 6.7 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF272) RRM_3 PF08777.11 EDO07719.1 - 1.2 9.2 0.0 1.2 9.2 0.0 3.1 4 0 0 4 4 4 0 RNA binding motif SPX PF03105.19 EDO07719.1 - 3.7 7.4 24.8 7.1 6.4 20.1 2.2 2 0 0 2 2 2 0 SPX domain MFS_1 PF07690.16 EDO07720.1 - 0.27 10.1 7.5 0.14 11.1 4.7 1.9 2 0 0 2 2 2 0 Major Facilitator Superfamily DUF3273 PF11677.8 EDO07721.1 - 6.7e-106 353.5 10.9 7.9e-106 353.2 10.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) Vps52 PF04129.12 EDO07722.1 - 1.4e-38 132.9 2.8 3.7e-38 131.5 2.8 1.6 1 1 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.9 EDO07722.1 - 0.0018 16.7 7.2 0.077 11.4 0.4 3.1 3 0 0 3 3 3 3 Exocyst complex component Sec3 V-ATPase_G PF03179.15 EDO07723.1 - 2.1e-17 63.6 8.2 2.4e-17 63.4 8.2 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit ATP-synt_B PF00430.18 EDO07723.1 - 0.0044 17.1 6.4 0.0044 17.1 6.4 1.9 1 1 1 2 2 2 1 ATP synthase B/B' CF(0) DUF4633 PF15464.6 EDO07723.1 - 0.044 13.9 0.2 0.062 13.5 0.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4633) Myb_DNA-binding PF00249.31 EDO07723.1 - 0.29 11.3 1.4 0.48 10.6 0.2 1.9 2 0 0 2 2 2 0 Myb-like DNA-binding domain V-ATPase_G_2 PF16999.5 EDO07723.1 - 1.5 9.3 11.5 4.6 7.7 11.6 1.7 1 1 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit Acetyltransf_1 PF00583.25 EDO07724.1 - 1.6e-16 60.6 0.0 3.9e-16 59.3 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDO07724.1 - 1.8e-08 34.4 0.0 3e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDO07724.1 - 7e-07 29.6 0.0 1.5e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EDO07724.1 - 0.00091 19.3 0.0 0.0019 18.3 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 EDO07724.1 - 0.0038 17.2 0.0 0.0099 15.8 0.0 1.7 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_4 PF13420.7 EDO07724.1 - 0.013 15.6 0.1 0.03 14.5 0.0 1.6 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain PanZ PF12568.8 EDO07724.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Ribosomal_L23 PF00276.20 EDO07725.1 - 4.7e-16 58.9 1.6 4.7e-16 58.9 1.6 2.6 2 2 0 2 2 2 1 Ribosomal protein L23 Ribosomal_L23eN PF03939.13 EDO07725.1 - 0.00023 21.3 6.2 0.00023 21.3 6.2 1.9 2 0 0 2 2 2 1 Ribosomal protein L23, N-terminal domain SRPRB PF09439.10 EDO07725.1 - 0.0046 16.4 0.4 0.0063 16.0 0.3 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Ribosomal_L4 PF00573.22 EDO07725.1 - 0.25 11.0 3.2 0.29 10.8 3.2 1.2 1 1 0 1 1 1 0 Ribosomal protein L4/L1 family Paf1 PF03985.13 EDO07726.1 - 2.2e-07 30.3 0.0 3.5e-06 26.3 0.0 2.2 2 0 0 2 2 2 1 Paf1 GDPD_2 PF13653.6 EDO07726.1 - 0.17 12.4 0.0 11 6.6 0.0 2.5 2 0 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family Got1 PF04178.12 EDO07728.1 - 1.2e-21 77.3 17.6 1.6e-21 76.8 17.6 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family RCC1 PF00415.18 EDO07730.1 - 4e-36 123.4 4.7 1e-13 51.6 0.0 7.4 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EDO07730.1 - 1.1e-23 82.4 13.4 4.2e-06 26.4 0.1 6.4 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat TAXi_N PF14543.6 EDO07731.1 - 1.9e-17 64.1 0.2 1.9e-17 64.1 0.2 1.9 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal Asp PF00026.23 EDO07731.1 - 7.2e-12 45.4 2.4 1.1e-07 31.6 0.1 3.3 3 1 0 3 3 3 3 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EDO07731.1 - 0.14 12.8 0.0 36 5.1 0.0 3.2 4 0 0 4 4 4 0 Aspartyl protease UCH PF00443.29 EDO07732.1 - 4.3e-25 88.7 0.0 8.4e-25 87.7 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDO07732.1 - 7.7e-10 38.9 0.0 2.3e-05 24.2 0.0 2.7 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase LYTB PF02401.18 EDO07733.1 - 1e-77 261.0 0.0 1.2e-77 260.7 0.0 1.1 1 0 0 1 1 1 1 LytB protein DUF3228 PF11539.8 EDO07734.1 - 5.6e-80 267.5 0.0 6.4e-80 267.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3228) AviRa PF11599.8 EDO07734.1 - 0.088 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Pyr_redox_2 PF07992.14 EDO07735.1 - 4.1e-44 151.0 2.2 5.6e-44 150.5 2.2 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.26 EDO07735.1 - 9.8e-15 54.3 0.5 2.3e-14 53.1 0.5 1.7 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Pyr_redox PF00070.27 EDO07735.1 - 2.9e-13 50.2 6.9 6.5e-13 49.1 1.5 3.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Rieske_2 PF13806.6 EDO07735.1 - 1.6e-07 31.2 0.1 2.3e-06 27.4 0.0 2.7 3 1 0 3 3 3 1 Rieske-like [2Fe-2S] domain Pyr_redox_3 PF13738.6 EDO07735.1 - 1.6e-07 30.9 2.1 0.009 15.3 0.0 2.5 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Reductase_C PF14759.6 EDO07735.1 - 8.2e-06 26.3 0.0 3.9e-05 24.1 0.0 2.2 2 0 0 2 2 2 1 Reductase C-terminal Lycopene_cycl PF05834.12 EDO07735.1 - 0.0033 16.5 1.2 7.1 5.6 0.0 3.3 3 0 0 3 3 3 2 Lycopene cyclase protein Amino_oxidase PF01593.24 EDO07735.1 - 0.0038 16.6 0.0 0.0072 15.7 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.24 EDO07735.1 - 0.014 15.0 3.2 2 7.9 0.2 3.1 3 1 0 4 4 4 0 FAD dependent oxidoreductase TrkA_N PF02254.18 EDO07735.1 - 0.024 14.9 0.4 11 6.4 0.0 3.7 3 1 1 4 4 4 0 TrkA-N domain NAD_binding_7 PF13241.6 EDO07735.1 - 0.037 14.5 0.7 0.47 10.9 0.3 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding NAD_binding_8 PF13450.6 EDO07735.1 - 0.041 14.1 0.5 22 5.4 0.4 3.7 4 0 0 4 4 3 0 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EDO07735.1 - 0.11 11.5 1.0 3.4 6.6 0.1 2.7 2 1 0 2 2 2 0 Glucose inhibited division protein A DUF3796 PF12676.7 EDO07735.1 - 0.13 12.7 0.1 0.25 11.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3796) NAD_binding_9 PF13454.6 EDO07735.1 - 0.2 11.6 0.1 0.2 11.6 0.1 2.4 3 0 0 3 3 3 0 FAD-NAD(P)-binding 3HCDH_N PF02737.18 EDO07735.1 - 0.23 11.3 1.8 0.4 10.5 1.8 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 EDO07735.1 - 4.8 5.8 7.9 2.2 6.9 0.0 3.3 3 1 1 4 4 4 0 HI0933-like protein Trp_halogenase PF04820.14 EDO07735.1 - 6.7 5.4 8.5 1.3 7.8 0.2 3.0 2 1 1 3 3 3 0 Tryptophan halogenase Chorein_N PF12624.7 EDO07737.1 - 6.8e-28 97.1 0.0 2.4e-27 95.4 0.0 2.0 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 EDO07737.1 - 1.1e-06 28.6 0.1 2.6e-06 27.4 0.1 1.6 1 0 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal ATG_C PF09333.11 EDO07737.1 - 1.6e-05 25.1 0.1 5.2e-05 23.5 0.1 1.8 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain SHR-BD PF06650.12 EDO07737.1 - 0.023 14.1 0.1 0.17 11.2 0.0 2.3 2 0 0 2 2 2 0 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_C PF16909.5 EDO07737.1 - 0.027 14.3 3.1 15 5.3 0.0 3.5 3 0 0 3 3 3 0 Vacuolar-sorting-associated 13 protein C-terminal DEAD PF00270.29 EDO07738.1 - 1.5e-15 57.5 0.0 3e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EDO07738.1 - 3.1e-09 37.1 0.0 9.4e-09 35.5 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDO07738.1 - 0.004 17.5 0.0 0.011 16.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Ras PF00071.22 EDO07739.1 - 4.9e-57 192.0 0.6 6e-57 191.8 0.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO07739.1 - 2e-33 115.2 0.1 3.3e-33 114.5 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO07739.1 - 1.9e-12 47.0 0.0 2.3e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EDO07739.1 - 2.4e-08 34.0 0.0 3.8e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EDO07739.1 - 2.4e-06 27.1 0.1 3e-06 26.8 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EDO07739.1 - 9.5e-05 22.0 0.2 0.0039 16.8 0.2 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain G-alpha PF00503.20 EDO07739.1 - 0.00014 21.2 1.2 0.049 12.8 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit RsgA_GTPase PF03193.16 EDO07739.1 - 0.0002 21.3 0.4 0.0024 17.8 0.1 2.3 1 1 2 3 3 3 1 RsgA GTPase Septin PF00735.18 EDO07739.1 - 0.00096 18.5 0.1 0.0041 16.4 0.0 1.9 2 0 0 2 2 2 1 Septin ATPase_2 PF01637.18 EDO07739.1 - 0.0013 18.7 0.2 0.0021 18.0 0.2 1.6 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea SRPRB PF09439.10 EDO07739.1 - 0.0019 17.7 0.1 0.0033 16.9 0.0 1.4 2 0 0 2 2 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 EDO07739.1 - 0.0019 18.6 0.0 0.0021 18.5 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain cobW PF02492.19 EDO07739.1 - 0.002 17.7 0.1 0.0061 16.2 0.0 1.7 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 EDO07739.1 - 0.0035 17.1 0.0 0.0059 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 EDO07739.1 - 0.0085 15.9 0.3 0.73 9.6 0.1 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_7 PF12775.7 EDO07739.1 - 0.011 15.3 0.0 0.023 14.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 EDO07739.1 - 0.015 14.7 0.0 0.026 13.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA_22 PF13401.6 EDO07739.1 - 0.016 15.5 0.0 0.035 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EDO07739.1 - 0.029 14.3 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain PduV-EutP PF10662.9 EDO07739.1 - 0.03 14.1 0.1 0.059 13.1 0.1 1.6 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DAP3 PF10236.9 EDO07739.1 - 0.035 13.3 0.0 0.072 12.2 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 RNA_helicase PF00910.22 EDO07739.1 - 0.049 14.0 0.0 0.14 12.6 0.0 1.8 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 EDO07739.1 - 0.061 13.8 0.4 0.099 13.2 0.4 1.7 1 1 0 1 1 1 0 ABC transporter TrwB_AAD_bind PF10412.9 EDO07739.1 - 0.068 12.1 0.1 0.34 9.8 0.0 1.9 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain NTPase_1 PF03266.15 EDO07739.1 - 0.087 12.7 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 NTPase AAA_14 PF13173.6 EDO07739.1 - 0.092 12.8 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain MCM PF00493.23 EDO07739.1 - 0.11 11.6 0.0 0.21 10.6 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain DUF21 PF01595.20 EDO07740.1 - 1.7 8.3 4.4 8.9 6.0 4.4 2.0 1 1 0 1 1 1 0 Cyclin M transmembrane N-terminal domain Comm PF15957.5 EDO07740.1 - 2 8.8 8.3 5.8 7.3 7.0 2.2 1 1 1 2 2 2 0 Commissureless Rer1 PF03248.13 EDO07741.1 - 8.7e-61 204.6 9.3 1e-60 204.4 9.3 1.0 1 0 0 1 1 1 1 Rer1 family CCDC23 PF15674.5 EDO07741.1 - 0.099 12.7 0.0 0.32 11.0 0.0 1.8 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 23 Nucleoporin_N PF08801.11 EDO07742.1 - 0.002 16.9 0.0 0.029 13.1 0.0 2.3 2 0 0 2 2 2 2 Nup133 N terminal like Cullin PF00888.22 EDO07743.1 - 4.7e-57 194.0 7.6 6.8e-57 193.4 7.6 1.2 1 0 0 1 1 1 1 Cullin family DOT1 PF08123.13 EDO07744.1 - 2.4e-05 24.0 0.0 5.6e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Histone methylation protein DOT1 ANAPC4 PF12896.7 EDO07744.1 - 0.037 13.5 0.1 0.11 12.0 0.0 1.7 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 4 zf-RanBP PF00641.18 EDO07745.1 - 0.00027 20.2 1.9 0.00046 19.4 1.9 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Img2 PF05046.14 EDO07746.1 - 3.9e-17 62.3 0.4 5.8e-17 61.8 0.4 1.3 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) AAA_12 PF13087.6 EDO07748.1 - 4.3e-54 183.2 0.0 1.8e-53 181.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EDO07748.1 - 3e-41 141.9 0.1 1.3e-24 87.4 0.0 2.6 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 EDO07748.1 - 1.6e-09 37.7 0.0 1.2e-08 35.0 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDO07748.1 - 8.7e-09 35.9 0.0 2.5e-08 34.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EDO07748.1 - 0.00043 20.3 0.0 0.0025 17.8 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PIF1 PF05970.14 EDO07748.1 - 0.00046 19.5 0.0 0.015 14.5 0.0 2.2 2 0 0 2 2 2 1 PIF1-like helicase dsrm PF00035.26 EDO07748.1 - 0.00089 19.9 1.5 0.21 12.3 0.0 3.9 3 1 0 3 3 3 1 Double-stranded RNA binding motif PhoH PF02562.16 EDO07748.1 - 0.00091 18.7 0.0 0.028 13.9 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein DUF2075 PF09848.9 EDO07748.1 - 0.001 18.4 0.0 0.59 9.3 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 EDO07748.1 - 0.0028 16.8 0.0 0.0061 15.6 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_23 PF13476.6 EDO07748.1 - 0.0064 17.0 0.0 0.024 15.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 EDO07748.1 - 0.01 15.7 0.0 0.034 14.0 0.0 2.0 1 1 0 1 1 1 0 Helicase Mg_chelatase PF01078.21 EDO07748.1 - 0.016 14.6 0.0 0.084 12.2 0.0 2.1 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA PF00004.29 EDO07748.1 - 0.016 15.6 0.0 0.2 12.1 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 EDO07748.1 - 0.024 14.4 0.0 0.056 13.2 0.0 1.6 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_5 PF07728.14 EDO07748.1 - 0.035 14.1 0.3 0.24 11.4 0.0 2.5 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EDO07748.1 - 0.037 13.8 0.0 0.085 12.6 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein NACHT PF05729.12 EDO07748.1 - 0.077 12.9 0.0 0.27 11.1 0.0 2.0 2 0 0 2 2 1 0 NACHT domain UvrD-helicase PF00580.21 EDO07748.1 - 0.094 12.2 0.0 0.21 11.1 0.0 1.6 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Sigma54_activat PF00158.26 EDO07748.1 - 0.15 11.8 0.0 0.37 10.5 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_16 PF13191.6 EDO07748.1 - 0.17 12.3 0.0 0.39 11.1 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain Alba PF01918.21 EDO07749.1 - 3.9e-14 52.2 0.0 5.6e-14 51.7 0.0 1.3 1 0 0 1 1 1 1 Alba Steroid_dh PF02544.16 EDO07750.1 - 8.3e-31 107.0 13.3 1.3e-30 106.3 13.3 1.3 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase FPP PF05911.11 EDO07751.1 - 0.0017 16.6 16.2 0.0017 16.6 16.2 2.4 1 1 1 2 2 2 1 Filament-like plant protein, long coiled-coil CorA PF01544.18 EDO07751.1 - 0.0019 17.6 8.9 0.0019 17.6 8.9 2.6 2 1 2 4 4 4 2 CorA-like Mg2+ transporter protein NPV_P10 PF05531.12 EDO07751.1 - 0.0031 17.9 12.5 1.1 9.8 0.0 4.4 1 1 2 3 3 3 1 Nucleopolyhedrovirus P10 protein CENP-F_leu_zip PF10473.9 EDO07751.1 - 0.0033 17.5 8.5 0.0033 17.5 8.5 2.7 2 1 1 3 3 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BRE1 PF08647.11 EDO07751.1 - 0.0066 16.5 9.4 0.0066 16.5 9.4 3.4 3 1 1 4 4 3 1 BRE1 E3 ubiquitin ligase TPR_MLP1_2 PF07926.12 EDO07751.1 - 0.01 15.9 28.1 0.53 10.4 20.6 3.4 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein LPP PF04728.13 EDO07751.1 - 0.037 14.4 5.0 15 6.1 1.4 4.0 2 1 1 3 3 3 0 Lipoprotein leucine-zipper Syntaxin-6_N PF09177.11 EDO07751.1 - 0.042 14.4 18.5 0.37 11.4 6.2 3.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Med9 PF07544.13 EDO07751.1 - 0.057 13.5 18.4 0.23 11.6 4.1 3.3 1 1 2 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 USP8_interact PF08941.10 EDO07751.1 - 0.13 12.0 11.2 0.13 12.1 0.3 2.8 2 1 1 3 3 3 0 USP8 interacting Spc7 PF08317.11 EDO07751.1 - 0.25 10.2 31.1 1.4 7.8 15.2 2.4 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF812 PF05667.11 EDO07751.1 - 0.58 9.0 30.0 5.5 5.8 28.2 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF812) FlaC_arch PF05377.11 EDO07751.1 - 0.74 10.2 16.2 5.5 7.5 1.1 4.2 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) SlyX PF04102.12 EDO07751.1 - 0.91 10.2 16.7 0.65 10.7 0.7 3.8 2 1 1 3 3 3 0 SlyX KASH_CCD PF14662.6 EDO07751.1 - 0.95 9.3 36.5 0.59 9.9 29.5 2.8 2 1 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH YscO PF07321.12 EDO07751.1 - 1 9.3 26.3 0.55 10.2 4.9 2.7 1 1 1 2 2 2 0 Type III secretion protein YscO ERM PF00769.19 EDO07751.1 - 1.4 8.7 30.8 0.31 10.8 5.7 2.8 3 0 0 3 3 3 0 Ezrin/radixin/moesin family DUF4407 PF14362.6 EDO07751.1 - 1.5 8.1 20.5 0.43 9.9 13.7 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) LMBR1 PF04791.16 EDO07751.1 - 2.6 6.8 13.0 3.8 6.3 13.0 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF724 PF05266.14 EDO07751.1 - 4.7 7.0 23.9 9.6 6.0 10.3 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF4988 PF16378.5 EDO07751.1 - 5.6 6.6 10.3 6 6.5 0.2 3.7 1 1 3 4 4 4 0 Domain of unknown function Nup54 PF13874.6 EDO07751.1 - 6.2 6.9 22.0 0.18 11.9 8.5 2.6 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 YabA PF06156.13 EDO07751.1 - 6.5 7.5 24.0 1.6 9.4 4.0 4.1 2 1 1 3 3 2 0 Initiation control protein YabA HIP1_clath_bdg PF16515.5 EDO07751.1 - 8.4 7.1 25.5 1.4 9.6 5.7 3.8 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Seryl_tRNA_N PF02403.22 EDO07751.1 - 8.4 6.7 24.6 11 6.3 4.6 3.0 2 1 1 3 3 2 0 Seryl-tRNA synthetase N-terminal domain V_ATPase_I PF01496.19 EDO07751.1 - 9.1 4.1 24.9 0.33 8.8 7.5 2.2 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family DivIC PF04977.15 EDO07751.1 - 9.5 6.1 24.1 0.75 9.6 2.2 4.1 1 1 3 4 4 4 0 Septum formation initiator Lebercilin PF15619.6 EDO07751.1 - 9.7 5.8 36.4 0.34 10.5 22.4 2.9 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DUF3450 PF11932.8 EDO07751.1 - 9.7 5.4 20.2 1.4 8.2 6.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) MOZART1 PF12554.8 EDO07752.1 - 5.7e-22 77.2 0.2 7.2e-22 76.9 0.2 1.1 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated RNaseH_pPIWI_RE PF13032.6 EDO07752.1 - 0.17 11.7 0.0 0.17 11.7 0.0 1.1 1 0 0 1 1 1 0 RNaseH domain of pPIWI_RE TMCO5 PF14992.6 EDO07753.1 - 0.056 13.0 27.7 0.0064 16.1 20.9 2.6 2 1 1 3 3 3 0 TMCO5 family HAP1_N PF04849.13 EDO07753.1 - 0.17 11.0 24.3 0.38 9.9 23.5 1.9 1 1 0 1 1 1 0 HAP1 N-terminal conserved region TolA_bind_tri PF16331.5 EDO07753.1 - 6.4 6.9 20.6 0.3 11.2 1.9 3.7 3 0 0 3 3 3 0 TolA binding protein trimerisation T3SSipB PF16535.5 EDO07753.1 - 8.5 6.8 13.2 0.39 11.2 3.6 2.6 2 1 0 2 2 2 0 Type III cell invasion protein SipB RRM_1 PF00076.22 EDO07754.1 - 1.7e-18 66.2 0.0 2.1e-18 65.9 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EDO07754.1 - 0.00024 21.1 0.0 0.00032 20.7 0.0 1.2 1 0 0 1 1 1 1 RNA binding motif RRM_5 PF13893.6 EDO07754.1 - 0.0054 16.3 0.0 0.0074 15.9 0.0 1.3 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDO07754.1 - 0.0066 16.4 0.0 0.0095 15.9 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EDO07754.1 - 0.035 14.0 0.0 0.054 13.3 0.0 1.3 1 1 0 1 1 1 0 Occluded RNA-recognition motif Limkain-b1 PF11608.8 EDO07754.1 - 0.08 13.0 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Limkain b1 PHM7_cyt PF14703.6 EDO07754.1 - 0.082 13.1 0.1 1.9 8.7 0.1 2.0 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 EDO07754.1 - 0.093 12.9 0.1 0.2 11.8 0.1 1.6 1 1 0 1 1 1 0 RNA recognition motif CorC_HlyC PF03471.17 EDO07754.1 - 0.11 12.5 0.2 0.27 11.3 0.2 1.7 1 1 0 1 1 1 0 Transporter associated domain HHH_7 PF14635.6 EDO07755.1 - 5.4e-23 81.3 0.0 1.2e-22 80.2 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif SH2_2 PF14633.6 EDO07755.1 - 1.1e-17 64.1 0.0 2.7e-17 62.9 0.0 1.7 1 0 0 1 1 1 1 SH2 domain HTH_44 PF14641.6 EDO07755.1 - 2.9e-08 34.1 0.1 8.3e-08 32.7 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.6 EDO07755.1 - 7.7e-05 23.2 15.2 7.7e-05 23.2 15.2 4.3 4 0 0 4 4 4 1 Acidic N-terminal SPT6 MT-A70 PF05063.14 EDO07757.1 - 2.1e-54 184.0 0.4 3.4e-54 183.3 0.4 1.3 1 0 0 1 1 1 1 MT-A70 EF-hand_1 PF00036.32 EDO07758.1 - 5.5e-24 81.9 5.6 4.7e-07 28.9 0.0 4.3 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 EDO07758.1 - 1.1e-23 83.4 2.6 6.6e-13 48.9 1.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EDO07758.1 - 5.2e-22 75.9 5.7 2.5e-08 33.2 0.0 4.7 4 1 1 5 5 5 3 EF-hand domain EF-hand_8 PF13833.6 EDO07758.1 - 4.4e-18 64.9 8.6 1.8e-08 34.1 0.6 3.6 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 EDO07758.1 - 1.2e-11 43.5 7.1 0.011 15.2 0.0 4.2 3 1 1 4 4 4 3 EF hand EF-hand_9 PF14658.6 EDO07758.1 - 8.2e-07 29.3 0.0 0.00018 21.7 0.0 2.5 2 1 0 2 2 2 1 EF-hand domain EF-hand_14 PF17959.1 EDO07758.1 - 7.5e-06 26.2 0.5 0.13 12.6 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_11 PF08976.11 EDO07758.1 - 0.016 16.1 0.2 0.22 12.4 0.1 2.1 1 1 1 2 2 2 0 EF-hand domain Caleosin PF05042.13 EDO07758.1 - 0.022 14.7 0.2 0.65 9.9 0.0 2.6 1 1 1 3 3 3 0 Caleosin related protein PMBR PF09373.10 EDO07758.1 - 0.081 13.1 0.6 13 6.1 0.0 3.7 3 1 1 4 4 4 0 Pseudomurein-binding repeat EF-hand_4 PF12763.7 EDO07758.1 - 0.18 11.8 1.6 15 5.6 0.2 2.8 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand DUF2746 PF10874.8 EDO07759.1 - 0.074 13.5 1.0 1.6 9.2 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2746) Ribosomal_L28e PF01778.17 EDO07762.1 - 6.6e-20 72.0 0.2 8.2e-20 71.7 0.2 1.1 1 0 0 1 1 1 1 Ribosomal L28e protein family DUF3291 PF11695.8 EDO07762.1 - 0.082 12.6 0.0 0.19 11.4 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3291) Cyclin_N PF00134.23 EDO07763.1 - 1.3e-06 28.1 0.5 2.7e-06 27.1 0.5 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Ribosomal_L35Ae PF01247.18 EDO07764.1 - 2.4e-42 143.0 0.5 2.8e-42 142.8 0.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 EDO07764.1 - 0.0013 18.9 0.0 0.7 10.2 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain Porin_3 PF01459.22 EDO07765.1 - 7.6e-06 25.6 1.8 9.8e-06 25.2 1.8 1.1 1 0 0 1 1 1 1 Eukaryotic porin cobW PF02492.19 EDO07766.1 - 8.9e-36 123.1 0.0 2.8e-35 121.5 0.0 1.9 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EDO07766.1 - 6.5e-06 26.0 0.0 2.3e-05 24.3 0.0 1.9 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain MeaB PF03308.16 EDO07766.1 - 0.00039 19.5 0.0 0.2 10.6 0.0 2.3 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB Viral_helicase1 PF01443.18 EDO07766.1 - 0.0014 18.5 0.0 0.0024 17.7 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_33 PF13671.6 EDO07766.1 - 0.0019 18.3 0.0 0.0034 17.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDO07766.1 - 0.0095 16.2 0.1 0.038 14.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain MobB PF03205.14 EDO07766.1 - 0.017 15.0 0.0 0.039 13.9 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.6 EDO07766.1 - 0.034 14.7 0.0 0.085 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EDO07766.1 - 0.053 13.5 0.0 0.099 12.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 EDO07766.1 - 0.067 13.6 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain ATP_bind_1 PF03029.17 EDO07766.1 - 0.088 12.6 0.2 0.58 9.9 0.0 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_29 PF13555.6 EDO07766.1 - 0.11 12.2 0.1 0.39 10.5 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain NTPase_1 PF03266.15 EDO07766.1 - 0.13 12.1 0.2 0.85 9.5 0.1 2.0 2 0 0 2 2 2 0 NTPase BOP1NT PF08145.12 EDO07767.1 - 1.7e-89 300.2 6.8 2.4e-89 299.7 6.8 1.2 1 0 0 1 1 1 1 BOP1NT (NUC169) domain ANAPC4_WD40 PF12894.7 EDO07767.1 - 0.006 16.9 0.0 0.44 10.9 0.0 2.8 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain KorB PF08535.10 EDO07768.1 - 0.04 14.0 2.2 5.3 7.1 0.1 3.2 2 0 0 2 2 2 0 KorB domain IKKbetaNEMObind PF12179.8 EDO07768.1 - 0.077 13.0 4.5 4.4 7.4 0.9 3.3 2 0 0 2 2 2 0 I-kappa-kinase-beta NEMO binding domain DUF1843 PF08898.10 EDO07768.1 - 0.1 13.1 5.3 10 6.7 0.1 5.1 3 1 1 4 4 4 0 Domain of unknown function (DUF1843) WD40 PF00400.32 EDO07770.1 - 1.8e-12 47.5 6.7 0.00023 21.9 0.1 6.3 6 1 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO07770.1 - 3e-06 27.4 0.1 0.0076 16.5 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EDO07770.1 - 0.012 14.9 0.0 0.024 14.0 0.0 1.5 1 0 0 1 1 1 0 WD40-like domain PQQ_2 PF13360.6 EDO07770.1 - 0.013 15.1 0.0 0.043 13.4 0.0 1.9 2 1 0 2 2 2 0 PQQ-like domain Fcf1 PF04900.12 EDO07771.1 - 2e-23 82.6 0.4 1.8e-22 79.6 0.0 2.1 2 0 0 2 2 2 1 Fcf1 PIN_9 PF18477.1 EDO07771.1 - 0.0082 16.4 0.0 0.016 15.5 0.0 1.5 1 0 0 1 1 1 1 PIN like domain rRNA_processing PF08524.11 EDO07772.1 - 1.2e-08 35.1 7.7 1.2e-08 35.1 7.7 2.4 2 1 0 2 2 2 1 rRNA processing ABC_tran_Xtn PF12848.7 EDO07772.1 - 2.4 8.2 12.9 0.11 12.6 4.7 2.3 2 0 0 2 2 2 0 ABC transporter TP53IP5 PF15331.6 EDO07772.1 - 5.4 7.1 20.8 2.3 8.3 10.3 2.1 2 0 0 2 2 2 0 Cellular tumour antigen p53-inducible 5 EMG1 PF03587.14 EDO07773.1 - 6.2e-29 101.0 0.2 1.2e-28 100.1 0.2 1.6 1 1 0 1 1 1 1 EMG1/NEP1 methyltransferase RE_HindVP PF09519.10 EDO07773.1 - 0.079 12.0 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 HindVP restriction endonuclease RFC1 PF08519.12 EDO07774.1 - 5.6e-30 104.6 0.0 1.1e-29 103.7 0.0 1.5 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain AAA PF00004.29 EDO07774.1 - 2e-13 50.9 0.0 5.4e-13 49.5 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BRCT PF00533.26 EDO07774.1 - 8e-11 42.2 0.0 2.2e-10 40.8 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Rad17 PF03215.15 EDO07774.1 - 1.3e-07 31.7 0.0 1.2e-06 28.6 0.0 2.3 1 1 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 EDO07774.1 - 0.00012 21.8 0.0 0.00022 21.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DNA_pol3_delta PF06144.13 EDO07774.1 - 0.00016 21.5 0.0 0.00047 20.0 0.0 1.8 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_16 PF13191.6 EDO07774.1 - 0.00036 21.0 0.0 0.00093 19.6 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EDO07774.1 - 0.0011 19.5 0.0 0.0032 18.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EDO07774.1 - 0.0016 17.7 0.0 0.0031 16.8 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin PTCB-BRCT PF12738.7 EDO07774.1 - 0.005 16.8 0.0 0.018 15.0 0.0 2.0 1 0 0 1 1 1 1 twin BRCT domain AAA_14 PF13173.6 EDO07774.1 - 0.011 15.7 0.0 0.059 13.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_assoc_2 PF16193.5 EDO07774.1 - 0.012 16.0 0.0 0.042 14.2 0.0 2.0 1 0 0 1 1 1 0 AAA C-terminal domain AAA_33 PF13671.6 EDO07774.1 - 0.012 15.8 0.2 0.046 13.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EDO07774.1 - 0.012 15.9 0.0 0.024 14.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_6 PF12774.7 EDO07774.1 - 0.015 14.3 0.1 0.024 13.6 0.1 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region DUF815 PF05673.13 EDO07774.1 - 0.022 14.0 0.0 0.046 12.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_17 PF13207.6 EDO07774.1 - 0.024 15.0 0.7 0.046 14.2 0.1 1.8 2 0 0 2 2 1 0 AAA domain AAA_22 PF13401.6 EDO07774.1 - 0.033 14.5 0.3 0.14 12.4 0.0 2.2 3 0 0 3 3 2 0 AAA domain NTPase_1 PF03266.15 EDO07774.1 - 0.082 12.8 0.1 0.25 11.3 0.1 1.8 1 1 1 2 2 2 0 NTPase Sigma54_activ_2 PF14532.6 EDO07774.1 - 0.14 12.2 0.0 0.36 10.9 0.0 1.8 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_5 PF07728.14 EDO07774.1 - 0.15 12.1 0.0 0.35 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF4196 PF13846.6 EDO07774.1 - 0.92 9.7 13.2 0.071 13.3 5.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4196) DUF4381 PF14316.6 EDO07775.1 - 0.035 14.3 0.1 0.062 13.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Ribosomal_S30 PF04758.14 EDO07776.1 - 1.2e-26 92.7 7.4 1.3e-26 92.6 7.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 Sec1 PF00995.23 EDO07777.1 - 1.7e-88 298.3 0.7 1.9e-88 298.1 0.7 1.0 1 0 0 1 1 1 1 Sec1 family TAF1_subA PF14929.6 EDO07777.1 - 0.031 13.7 0.0 0.054 12.9 0.0 1.3 1 0 0 1 1 1 0 TAF RNA Polymerase I subunit A ATP-synt_ab PF00006.25 EDO07780.1 - 3.1e-71 239.4 0.0 4.5e-71 238.9 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 EDO07780.1 - 1.4e-45 154.7 1.1 2.3e-45 154.0 1.1 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 EDO07780.1 - 2.5e-13 50.4 3.4 2.5e-13 50.4 3.4 2.0 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.10 EDO07780.1 - 0.00048 20.2 0.9 0.001 19.2 0.9 1.5 1 0 0 1 1 1 1 HAS barrel domain CECR6_TMEM121 PF14997.6 EDO07781.1 - 1.3e-15 57.8 6.6 1.3e-15 57.8 6.6 2.8 2 2 1 3 3 3 1 CECR6/TMEM121 family SMK-1 PF04802.15 EDO07782.1 - 9.9e-25 87.5 1.1 2.3e-24 86.3 1.1 1.6 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 Ran_BP1 PF00638.18 EDO07782.1 - 0.028 14.7 0.0 0.07 13.4 0.0 1.6 1 0 0 1 1 1 0 RanBP1 domain DNA_pol_E_B PF04042.16 EDO07783.1 - 4.8e-23 81.6 0.0 7.3e-23 81.0 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B BING4CT PF08149.11 EDO07784.1 - 3.6e-28 97.2 0.0 5.3e-26 90.2 0.0 2.8 3 0 0 3 3 3 2 BING4CT (NUC141) domain ANAPC4_WD40 PF12894.7 EDO07784.1 - 0.054 13.8 0.0 29 5.1 0.0 3.7 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain DUF5411 PF17424.2 EDO07784.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5411) Cwf_Cwc_15 PF04889.12 EDO07785.1 - 1.2e-32 113.6 23.5 1e-18 68.0 12.0 2.0 1 1 1 2 2 2 2 Cwf15/Cwc15 cell cycle control protein CENP-N PF05238.13 EDO07785.1 - 0.16 11.2 6.4 0.22 10.8 6.1 1.3 1 1 0 1 1 1 0 Kinetochore protein CHL4 like MAJIN PF15077.6 EDO07785.1 - 1.7 8.4 6.8 1.6 8.5 5.5 1.5 1 1 1 2 2 2 0 Membrane-anchored junction protein DUF2721 PF11026.8 EDO07785.1 - 3.7 7.4 5.3 1.5 8.7 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) YchF-GTPase_C PF06071.13 EDO07786.1 - 1.4e-39 134.2 1.0 2.5e-39 133.4 0.0 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EDO07786.1 - 6e-19 68.2 0.0 1.5e-18 66.9 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDO07786.1 - 1.4e-05 24.7 0.0 2.7e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA PF00004.29 EDO07786.1 - 0.0031 17.9 0.0 0.0058 17.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MeaB PF03308.16 EDO07786.1 - 0.06 12.3 0.5 0.76 8.7 0.0 2.2 2 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB FHA PF00498.26 EDO07786.1 - 0.11 12.8 0.1 0.35 11.2 0.0 1.8 2 0 0 2 2 2 0 FHA domain NuA4 PF09340.10 EDO07787.1 - 6.4e-08 32.4 0.1 6.6e-07 29.1 0.0 2.6 2 0 0 2 2 2 1 Histone acetyltransferase subunit NuA4 MAAL_N PF05034.13 EDO07787.1 - 0.012 15.2 0.0 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase N-terminus zf-MYND PF01753.18 EDO07788.1 - 1.7e-06 28.0 4.7 1.7e-06 28.0 4.7 2.1 2 0 0 2 2 2 1 MYND finger zf-Mss51 PF13824.6 EDO07788.1 - 0.015 15.4 2.1 0.034 14.2 2.1 1.6 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 CxC7 PF18866.1 EDO07788.1 - 0.28 11.3 3.0 0.26 11.5 0.6 2.2 3 0 0 3 3 3 0 CxC7 like cysteine cluster associated with KDZ transposases MRP-S25 PF13741.6 EDO07789.1 - 0.0009 18.9 0.0 0.0013 18.4 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 TPR_1 PF00515.28 EDO07790.1 - 3.8e-64 210.1 35.7 4.7e-09 35.7 0.3 9.4 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_2 PF07719.17 EDO07790.1 - 2e-54 177.4 32.3 1.3e-07 31.1 0.1 9.4 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_11 PF13414.6 EDO07790.1 - 4.4e-36 122.3 21.5 5.1e-08 32.5 0.4 8.9 4 2 4 8 8 8 8 TPR repeat TPR_8 PF13181.6 EDO07790.1 - 1.3e-34 115.5 27.6 8.5e-05 22.5 0.7 9.8 9 1 0 9 9 9 8 Tetratricopeptide repeat TPR_16 PF13432.6 EDO07790.1 - 1.8e-23 82.9 16.9 0.00012 22.6 0.9 6.5 3 3 3 6 6 6 6 Tetratricopeptide repeat TPR_12 PF13424.6 EDO07790.1 - 3.8e-23 81.6 21.1 8.8e-10 38.7 0.7 7.0 3 3 3 6 6 6 6 Tetratricopeptide repeat TPR_14 PF13428.6 EDO07790.1 - 1.4e-22 78.5 12.3 0.043 14.6 0.0 9.9 6 2 4 10 10 9 6 Tetratricopeptide repeat TPR_17 PF13431.6 EDO07790.1 - 2.1e-22 77.9 15.6 0.00029 21.0 0.3 8.9 9 0 0 9 9 8 5 Tetratricopeptide repeat STI1 PF17830.1 EDO07790.1 - 1.1e-21 76.5 17.1 1e-17 63.8 2.5 4.0 5 0 0 5 5 2 2 STI1 domain TPR_19 PF14559.6 EDO07790.1 - 1.3e-21 76.8 16.8 1.9e-07 31.5 0.5 6.8 4 2 2 6 6 6 6 Tetratricopeptide repeat TPR_9 PF13371.6 EDO07790.1 - 3.8e-17 62.2 4.8 7.8e-05 22.7 0.1 7.1 3 2 3 6 6 6 5 Tetratricopeptide repeat TPR_7 PF13176.6 EDO07790.1 - 1e-11 44.0 18.2 0.0054 16.7 0.3 8.8 9 1 0 9 9 9 3 Tetratricopeptide repeat TPR_10 PF13374.6 EDO07790.1 - 7.6e-11 41.5 21.5 0.45 10.5 0.1 8.2 9 0 0 9 9 9 5 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EDO07790.1 - 3.5e-10 39.8 15.9 0.35 11.0 0.0 7.2 8 0 0 8 8 7 4 Fis1 C-terminal tetratricopeptide repeat TPR_21 PF09976.9 EDO07790.1 - 6.5e-08 32.5 13.2 0.04 13.6 0.1 5.0 2 1 3 5 5 5 2 Tetratricopeptide repeat-like domain TPR_6 PF13174.6 EDO07790.1 - 2e-07 31.2 20.6 0.93 10.3 0.3 8.1 8 0 0 8 8 7 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO07790.1 - 4e-06 27.0 18.7 0.06 13.6 4.3 5.2 2 1 4 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 EDO07790.1 - 3.1e-05 24.2 3.1 0.72 10.2 0.0 4.0 3 1 0 3 3 3 2 Tetratricopeptide repeat NARP1 PF12569.8 EDO07790.1 - 5.9e-05 22.2 20.9 0.071 12.0 0.7 4.8 2 1 3 5 5 5 3 NMDA receptor-regulated protein 1 BTAD PF03704.17 EDO07790.1 - 0.00026 21.5 9.8 1.6 9.2 0.2 5.2 3 2 2 5 5 5 2 Bacterial transcriptional activator domain DUF3856 PF12968.7 EDO07790.1 - 0.00051 20.1 9.8 5.1 7.2 0.1 5.8 3 3 2 5 5 5 1 Domain of Unknown Function (DUF3856) Alkyl_sulf_dimr PF14863.6 EDO07790.1 - 0.0027 18.2 1.8 0.12 12.8 0.3 3.4 2 1 0 2 2 2 1 Alkyl sulfatase dimerisation ChAPs PF09295.10 EDO07790.1 - 0.0029 16.7 1.8 0.76 8.7 0.0 3.7 3 1 1 4 4 4 1 ChAPs (Chs5p-Arf1p-binding proteins) DUF3391 PF11871.8 EDO07790.1 - 0.0044 17.6 8.2 0.84 10.2 0.2 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF3391) Rapsyn_N PF10579.9 EDO07790.1 - 0.041 14.0 0.8 0.18 11.9 0.2 2.5 2 0 0 2 2 1 0 Rapsyn N-terminal myristoylation and linker region Virulence_fact PF13769.6 EDO07790.1 - 0.051 13.8 1.0 0.63 10.3 1.0 2.7 2 0 0 2 2 2 0 Virulence factor PPR PF01535.20 EDO07790.1 - 0.11 12.8 5.1 14 6.2 0.2 4.7 4 0 0 4 4 3 0 PPR repeat TPR_4 PF07721.14 EDO07790.1 - 0.23 12.2 4.6 14 6.6 0.1 4.6 6 0 0 6 6 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 EDO07790.1 - 0.37 10.8 18.0 2.4 8.3 0.0 5.9 6 0 0 6 6 5 0 Tetratricopeptide repeat MIT PF04212.18 EDO07790.1 - 0.43 10.7 20.5 0.48 10.5 2.5 6.7 7 0 0 7 7 7 0 MIT (microtubule interacting and transport) domain XPC-binding PF09280.11 EDO07790.1 - 0.71 9.6 10.8 4.4 7.1 0.7 4.0 3 1 1 4 4 3 0 XPC-binding domain DUF5113 PF17140.4 EDO07790.1 - 1 9.2 10.1 1.2 9.0 1.0 4.1 2 1 1 4 4 4 0 Domain of unknown function (DUF5113) SHNi-TPR PF10516.9 EDO07790.1 - 1.3 8.6 13.7 39 3.8 0.1 6.4 7 0 0 7 7 7 0 SHNi-TPR SBF_like PF13593.6 EDO07791.1 - 0.056 12.7 1.5 0.064 12.6 1.5 1.0 1 0 0 1 1 1 0 SBF-like CPA transporter family (DUF4137) AAA_5 PF07728.14 EDO07792.1 - 4.3e-102 337.7 0.0 9.3e-20 71.0 0.0 8.7 7 1 1 8 8 8 8 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EDO07792.1 - 2.3e-29 101.9 0.0 3.7e-10 39.8 0.0 6.4 7 0 0 7 7 6 3 ATPase family associated with various cellular activities (AAA) AAA_lid_7 PF17867.1 EDO07792.1 - 3.8e-24 84.9 4.5 1.4e-07 31.7 0.5 6.5 6 0 0 6 6 5 3 Midasin AAA lid domain AAA_7 PF12775.7 EDO07792.1 - 4.3e-19 68.7 0.2 0.00027 20.5 0.0 6.7 7 0 0 7 7 6 4 P-loop containing dynein motor region Dynein_heavy PF03028.15 EDO07792.1 - 1.9e-17 63.5 0.0 0.017 15.2 0.0 7.4 7 0 0 7 7 6 3 Dynein heavy chain region D6 P-loop domain AAA_16 PF13191.6 EDO07792.1 - 7.8e-17 62.2 0.2 0.017 15.5 0.0 5.5 5 0 0 5 5 5 4 AAA ATPase domain AAA PF00004.29 EDO07792.1 - 1.8e-15 57.5 0.1 0.028 14.9 0.0 5.8 5 0 0 5 5 5 4 ATPase family associated with various cellular activities (AAA) AAA_lid_5 PF17865.1 EDO07792.1 - 6e-15 55.2 0.0 6e-14 52.0 0.0 2.6 2 0 0 2 2 2 1 Midasin AAA lid domain AAA_18 PF13238.6 EDO07792.1 - 2.3e-12 47.6 0.0 0.011 16.3 0.0 5.6 5 0 0 5 5 4 3 AAA domain AAA_22 PF13401.6 EDO07792.1 - 2e-11 44.3 0.0 0.052 13.8 0.0 5.0 4 0 0 4 4 4 3 AAA domain TsaE PF02367.17 EDO07792.1 - 2.6e-11 43.6 1.9 0.13 12.3 0.0 5.4 6 0 0 6 6 4 3 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 EDO07792.1 - 8.2e-10 38.6 0.0 0.078 12.7 0.0 5.6 5 0 0 5 5 5 2 Sigma-54 interaction domain AAA_6 PF12774.7 EDO07792.1 - 4.9e-08 32.3 0.0 0.22 10.5 0.0 6.3 7 1 0 7 7 7 2 Hydrolytic ATP binding site of dynein motor region TniB PF05621.11 EDO07792.1 - 1.1e-07 31.4 0.0 0.23 10.8 0.0 4.7 4 0 0 4 4 4 2 Bacterial TniB protein Sigma54_activ_2 PF14532.6 EDO07792.1 - 1.6e-07 31.5 0.1 0.66 10.1 0.0 5.3 5 0 0 5 5 5 2 Sigma-54 interaction domain AAA_14 PF13173.6 EDO07792.1 - 9.8e-07 28.9 0.0 0.13 12.3 0.0 5.8 6 0 0 6 6 5 1 AAA domain ABC_tran PF00005.27 EDO07792.1 - 1.1e-06 29.2 0.0 0.1 13.1 0.0 5.1 5 0 0 5 5 5 1 ABC transporter AAA_8 PF12780.7 EDO07792.1 - 2.5e-06 27.0 0.0 0.041 13.2 0.0 4.2 5 0 0 5 5 4 2 P-loop containing dynein motor region D4 Mg_chelatase PF01078.21 EDO07792.1 - 3.9e-06 26.4 0.5 4.2 6.7 0.0 6.6 8 1 0 8 8 6 0 Magnesium chelatase, subunit ChlI NACHT PF05729.12 EDO07792.1 - 4.5e-06 26.7 1.0 3 7.7 0.1 5.3 5 0 0 5 5 5 1 NACHT domain AAA_33 PF13671.6 EDO07792.1 - 5.4e-06 26.6 0.0 6.5 6.9 0.0 5.6 5 0 0 5 5 5 0 AAA domain AAA_23 PF13476.6 EDO07792.1 - 0.00011 22.7 0.0 0.89 10.0 0.0 3.7 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EDO07792.1 - 0.00013 21.8 0.0 2 8.1 0.0 4.6 5 1 0 5 5 5 1 AAA domain T2SSE PF00437.20 EDO07792.1 - 0.00015 20.9 0.1 0.28 10.2 0.0 3.9 4 0 0 4 4 4 1 Type II/IV secretion system protein PduV-EutP PF10662.9 EDO07792.1 - 0.00016 21.4 0.2 1.8 8.3 0.0 4.2 4 0 0 4 4 4 1 Ethanolamine utilisation - propanediol utilisation SRP54 PF00448.22 EDO07792.1 - 0.00022 20.9 0.2 3.9 7.1 0.0 3.5 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain AAA_29 PF13555.6 EDO07792.1 - 0.00024 20.8 0.2 40 4.0 0.0 5.3 5 0 0 5 5 5 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 EDO07792.1 - 0.00025 21.4 0.1 17 5.9 0.0 5.0 5 0 0 5 5 4 0 RNA helicase RsgA_GTPase PF03193.16 EDO07792.1 - 0.00031 20.7 0.2 5.1 7.0 0.0 4.8 5 0 0 5 5 5 0 RsgA GTPase DUF815 PF05673.13 EDO07792.1 - 0.00036 19.8 0.9 15 4.6 0.0 4.8 5 0 0 5 5 5 0 Protein of unknown function (DUF815) Roc PF08477.13 EDO07792.1 - 0.00076 19.7 4.0 1.8 8.8 0.1 4.8 5 0 0 5 5 4 1 Ras of Complex, Roc, domain of DAPkinase MCM PF00493.23 EDO07792.1 - 0.0012 18.0 0.0 9.1 5.3 0.0 4.1 5 0 0 5 5 5 0 MCM P-loop domain AAA_19 PF13245.6 EDO07792.1 - 0.0014 19.0 0.7 8.4 6.7 0.0 4.3 4 0 0 4 4 3 0 AAA domain ATPase PF06745.13 EDO07792.1 - 0.0024 17.3 0.0 0.46 9.8 0.0 3.5 3 0 0 3 3 3 1 KaiC DEAD PF00270.29 EDO07792.1 - 0.0042 16.9 0.7 12 5.7 0.0 4.1 4 1 0 4 4 4 0 DEAD/DEAH box helicase AAA_25 PF13481.6 EDO07792.1 - 0.0047 16.5 0.7 9.5 5.7 0.0 4.0 4 0 0 4 4 4 0 AAA domain RuvB_N PF05496.12 EDO07792.1 - 0.0051 16.6 1.2 1.7 8.4 0.0 4.4 6 0 0 6 6 4 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 EDO07792.1 - 0.0058 16.4 0.0 8.8 6.0 0.0 4.2 4 0 0 4 4 4 0 IstB-like ATP binding protein VWA_CoxE PF05762.14 EDO07792.1 - 0.0094 15.4 0.0 0.025 14.0 0.0 1.7 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein VWA_2 PF13519.6 EDO07792.1 - 0.014 16.0 0.0 0.054 14.1 0.0 2.1 1 0 0 1 1 1 0 von Willebrand factor type A domain ResIII PF04851.15 EDO07792.1 - 0.021 14.8 0.0 13 5.7 0.0 3.2 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit Zeta_toxin PF06414.12 EDO07792.1 - 0.026 13.8 0.0 34 3.6 0.0 4.0 4 0 0 4 4 4 0 Zeta toxin AAA_24 PF13479.6 EDO07792.1 - 0.079 12.7 0.3 31 4.2 0.0 3.7 4 0 0 4 4 3 0 AAA domain MarR_2 PF12802.7 EDO07792.1 - 0.091 12.7 0.0 12 5.9 0.0 3.1 2 0 0 2 2 2 0 MarR family G-alpha PF00503.20 EDO07792.1 - 0.11 11.7 0.1 1.8 7.6 0.0 2.8 3 0 0 3 3 3 0 G-protein alpha subunit VWA PF00092.28 EDO07792.1 - 0.15 12.3 0.0 0.35 11.1 0.0 1.6 1 0 0 1 1 1 0 von Willebrand factor type A domain MAM33 PF02330.16 EDO07793.1 - 4.5e-34 118.2 1.3 1.9e-33 116.2 1.3 1.8 1 1 0 1 1 1 1 Mitochondrial glycoprotein Peptidase_M24 PF00557.24 EDO07794.1 - 2.8e-40 138.2 0.0 3.6e-40 137.9 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 COX15-CtaA PF02628.15 EDO07795.1 - 8e-85 284.7 7.5 9.6e-85 284.5 7.5 1.0 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein Ydr279_N PF17745.1 EDO07796.1 - 0.019 15.2 0.1 0.042 14.1 0.1 1.6 1 0 0 1 1 1 0 Ydr279p protein triple barrel domain VESA1_N PF12785.7 EDO07797.1 - 4.1e-219 728.2 24.1 4.1e-219 728.2 24.1 3.8 4 0 0 4 4 4 1 Variant erythrocyte surface antigen-1 SKA2 PF16740.5 EDO07797.1 - 0.00081 19.2 1.6 0.25 11.1 0.0 3.5 2 1 1 3 3 3 1 Spindle and kinetochore-associated protein 2 DDE_Tnp_1_assoc PF13808.6 EDO07797.1 - 0.019 15.0 0.0 0.078 13.0 0.0 2.0 1 0 0 1 1 1 0 DDE_Tnp_1-associated PhoU_div PF01865.16 EDO07797.1 - 0.052 12.9 1.0 0.12 11.7 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF47 Mlp PF03304.13 EDO07797.1 - 0.16 12.1 8.2 3.6 7.8 0.0 3.3 3 0 0 3 3 3 0 Mlp lipoprotein family Mg_chelatase PF01078.21 EDO07797.1 - 0.26 10.7 0.0 0.26 10.7 0.0 1.8 2 0 0 2 2 1 0 Magnesium chelatase, subunit ChlI DUF5082 PF16888.5 EDO07797.1 - 0.61 10.4 2.8 2.4 8.4 0.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) DUF948 PF06103.11 EDO07797.1 - 1.1 9.5 4.2 11 6.4 0.2 3.6 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Spc7 PF08317.11 EDO07797.1 - 1.2 7.9 6.2 2.2 7.1 0.8 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF1664 PF07889.12 EDO07797.1 - 2.1 8.4 4.8 4.2 7.4 0.3 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) SF-assemblin PF06705.11 EDO07797.1 - 4 6.7 7.6 7.9 5.7 0.6 2.3 2 0 0 2 2 2 0 SF-assemblin/beta giardin Leu_zip PF15294.6 EDO07797.1 - 4.7 6.7 6.9 3.8 7.0 1.4 2.2 2 0 0 2 2 2 0 Leucine zipper DUF1351 PF07083.11 EDO07797.1 - 7.4 6.3 8.7 5 6.8 0.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1351) CdvA PF18822.1 EDO07797.1 - 9.8 6.0 10.2 16 5.3 1.3 3.2 3 0 0 3 3 3 0 CdvA-like coiled-coil domain VESA1_N PF12785.7 EDO07798.1 - 2.6e-25 89.3 30.1 1.9e-24 86.5 12.5 4.4 2 1 1 3 3 3 2 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO07799.1 - 2.2e-209 696.1 21.1 2.2e-209 696.1 21.1 2.7 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 Pox_A6 PF04924.12 EDO07799.1 - 0.2 10.6 0.3 0.33 9.9 0.3 1.2 1 0 0 1 1 1 0 Poxvirus A6 protein F-box-like_2 PF13013.6 EDO07800.1 - 3.1e-15 56.0 1.9 1.3e-09 37.9 0.2 3.0 2 1 1 3 3 3 3 F-box-like domain GFO_IDH_MocA_C PF02894.17 EDO07800.1 - 0.17 11.9 0.0 67 3.5 0.0 3.0 2 1 1 3 3 3 0 Oxidoreductase family, C-terminal alpha/beta domain DUF2076 PF09849.9 EDO07801.1 - 0.047 13.7 0.2 0.07 13.2 0.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) ODV-E18 PF10717.9 EDO07802.1 - 0.33 10.8 2.9 23 4.9 0.0 3.4 3 0 0 3 3 3 0 Occlusion-derived virus envelope protein ODV-E18 OppC_N PF12911.7 EDO07802.1 - 1 9.4 0.0 1 9.4 0.0 4.0 4 0 0 4 4 4 0 N-terminal TM domain of oligopeptide transport permease C VESA1_N PF12785.7 EDO07803.1 - 1.2e-234 779.4 48.8 2.5e-224 745.4 24.8 3.4 2 1 1 3 3 3 3 Variant erythrocyte surface antigen-1 DDE_Tnp_1_assoc PF13808.6 EDO07803.1 - 0.0052 16.8 0.0 0.071 13.1 0.0 2.8 3 0 0 3 3 3 1 DDE_Tnp_1-associated Tox-REase-2 PF15646.6 EDO07803.1 - 0.048 13.8 0.1 0.13 12.5 0.1 1.6 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 2 Apolipoprotein PF01442.18 EDO07803.1 - 0.075 12.9 2.4 9.4 6.1 0.1 2.8 2 1 1 3 3 3 0 Apolipoprotein A1/A4/E domain DUF883 PF05957.13 EDO07803.1 - 0.51 11.0 4.0 20 5.9 0.1 3.0 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) FadA PF09403.10 EDO07803.1 - 0.69 10.4 4.5 3.4 8.2 0.0 3.3 3 1 0 3 3 3 0 Adhesion protein FadA DUF4175 PF13779.6 EDO07803.1 - 3.6 5.4 8.9 0.35 8.7 0.8 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4175) FIVAR PF07554.13 EDO07803.1 - 3.6 8.4 8.1 3.8 8.3 0.1 3.2 3 0 0 3 3 3 0 FIVAR domain PhdYeFM_antitox PF02604.19 EDO07805.1 - 0.13 12.1 0.1 0.31 10.9 0.1 1.6 1 0 0 1 1 1 0 Antitoxin Phd_YefM, type II toxin-antitoxin system Med31 PF05669.12 EDO07806.1 - 2.5e-33 113.9 4.1 3.1e-33 113.7 4.1 1.1 1 0 0 1 1 1 1 SOH1 WbqC PF08889.11 EDO07806.1 - 0.0061 16.5 0.1 0.0069 16.3 0.1 1.2 1 0 0 1 1 1 1 WbqC-like protein family ubiquitin PF00240.23 EDO07807.1 - 3.9e-07 29.7 0.3 9.8e-07 28.4 0.3 1.6 1 1 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 EDO07807.1 - 0.00027 21.3 0.2 0.0012 19.2 0.2 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_4 PF18036.1 EDO07807.1 - 0.029 14.4 0.3 0.28 11.2 0.2 1.9 1 1 1 2 2 2 0 Ubiquitin-like domain DHHC PF01529.20 EDO07808.1 - 2e-32 112.1 16.4 2e-32 112.1 16.4 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase Bromo_TP PF07524.13 EDO07809.1 - 0.0047 16.9 0.0 0.0094 15.9 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated DnaJ PF00226.31 EDO07810.1 - 5.9e-20 71.2 1.5 3e-18 65.7 1.5 2.4 1 1 0 1 1 1 1 DnaJ domain DUF3395 PF11875.8 EDO07810.1 - 2.5e-15 56.7 0.0 4.8e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) IPK PF03770.16 EDO07811.1 - 2.1e-22 80.0 0.0 4.5e-22 78.9 0.0 1.6 1 1 0 1 1 1 1 Inositol polyphosphate kinase Rib_5-P_isom_A PF06026.14 EDO07812.1 - 7e-51 172.3 0.1 8.9e-51 171.9 0.1 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 EDO07812.1 - 4.1e-05 23.6 0.2 0.023 14.6 0.1 2.2 1 1 1 2 2 2 2 DeoR C terminal sensor domain Sugar-bind PF04198.13 EDO07812.1 - 0.024 13.8 0.7 0.059 12.5 0.1 1.8 2 0 0 2 2 2 0 Putative sugar-binding domain DUF3530 PF12048.8 EDO07812.1 - 0.23 10.9 0.1 0.34 10.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) E3_UFM1_ligase PF09743.9 EDO07813.1 - 6.7e-51 173.5 0.9 1.8e-50 172.1 0.2 1.9 2 0 0 2 2 2 1 E3 UFM1-protein ligase 1 CTP_transf_like PF01467.26 EDO07814.1 - 5.9e-13 49.2 0.0 7.7e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like Pox_G9-A16 PF03003.16 EDO07814.1 - 0.058 13.1 0.2 0.1 12.3 0.0 1.6 2 0 0 2 2 2 0 Pox virus entry-fusion-complex G9/A16 AMP-binding PF00501.28 EDO07815.1 - 4.1e-77 259.6 0.0 5.2e-77 259.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDO07815.1 - 0.00058 20.8 0.1 0.0016 19.4 0.1 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Methyltransf_31 PF13847.6 EDO07816.1 - 1.5e-08 34.6 0.1 2.8e-08 33.7 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EDO07816.1 - 3.8e-08 33.1 0.1 6.2e-08 32.4 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EDO07816.1 - 1.1e-07 32.5 0.1 2.4e-07 31.3 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDO07816.1 - 1.1e-05 26.0 0.1 2.3e-05 25.0 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EDO07816.1 - 0.00028 20.7 0.1 0.00056 19.7 0.1 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 EDO07816.1 - 0.00084 19.2 0.0 0.0018 18.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EDO07816.1 - 0.0027 17.3 0.3 0.0063 16.1 0.1 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_16 PF10294.9 EDO07816.1 - 0.0085 15.8 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase Ubie_methyltran PF01209.18 EDO07816.1 - 0.012 15.0 0.1 0.02 14.2 0.1 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 EDO07816.1 - 0.017 14.1 0.0 0.029 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) DOT1 PF08123.13 EDO07816.1 - 0.019 14.5 0.1 0.033 13.7 0.1 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_32 PF13679.6 EDO07816.1 - 0.055 13.5 0.0 0.097 12.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Nudc_N PF14050.6 EDO07817.1 - 1.5e-13 50.5 0.4 2.9e-13 49.6 0.4 1.4 1 0 0 1 1 1 1 N-terminal conserved domain of Nudc. CS PF04969.16 EDO07817.1 - 1.9e-13 51.2 0.0 4.1e-13 50.1 0.0 1.6 1 0 0 1 1 1 1 CS domain CzcE PF16986.5 EDO07817.1 - 0.18 12.2 0.0 4.8 7.6 0.0 2.3 2 0 0 2 2 2 0 Heavy-metal resistance protein CzcE tRNA-synt_1b PF00579.25 EDO07818.1 - 1.1e-23 84.1 0.0 1.8e-23 83.3 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) zf-C2HC5 PF06221.13 EDO07819.1 - 1.8e-05 24.6 5.9 1.8e-05 24.6 5.9 1.8 2 0 0 2 2 2 1 Putative zinc finger motif, C2HC5-type IMP_cyclohyd PF07826.11 EDO07819.1 - 0.011 15.3 0.1 0.022 14.4 0.1 1.4 1 0 0 1 1 1 0 IMP cyclohydrolase-like protein Arm-DNA-bind_5 PF17293.2 EDO07819.1 - 0.031 14.7 0.0 0.073 13.5 0.0 1.6 1 0 0 1 1 1 0 Arm DNA-binding domain PPTA PF01239.22 EDO07820.1 - 1e-20 72.7 13.3 4.4e-06 26.3 0.3 4.4 4 0 0 4 4 4 4 Protein prenyltransferase alpha subunit repeat RINGv PF12906.7 EDO07820.1 - 0.075 13.2 0.9 0.26 11.5 0.9 1.9 1 0 0 1 1 1 0 RING-variant domain tRNA_m1G_MT PF01746.21 EDO07824.1 - 4.6e-21 75.4 0.0 6.2e-21 75.0 0.0 1.2 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase DXP_synthase_N PF13292.6 EDO07825.1 - 2.5e-78 263.1 0.1 4e-73 246.0 0.0 2.6 3 0 0 3 3 3 2 1-deoxy-D-xylulose-5-phosphate synthase Transket_pyr PF02779.24 EDO07825.1 - 3.9e-33 114.6 0.1 8.4e-33 113.5 0.1 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EDO07825.1 - 8.1e-17 61.3 0.0 2e-16 60.0 0.0 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain Transketolase_N PF00456.21 EDO07825.1 - 0.11 11.4 0.4 0.47 9.3 0.0 2.1 3 0 0 3 3 3 0 Transketolase, thiamine diphosphate binding domain NADH_dehy_S2_C PF06444.11 EDO07825.1 - 0.14 12.7 2.4 0.35 11.4 2.4 1.6 1 0 0 1 1 1 0 NADH dehydrogenase subunit 2 C-terminus Peptidase_M3 PF01432.20 EDO07826.1 - 1e-46 160.2 0.0 4.2e-46 158.2 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M3 Rib PF08428.10 EDO07826.1 - 0.017 15.1 0.1 0.029 14.4 0.1 1.3 1 0 0 1 1 1 0 Rib/alpha-like repeat Ank_2 PF12796.7 EDO07827.1 - 8.9e-40 135.2 3.2 1.1e-12 48.3 0.0 4.5 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDO07827.1 - 3.2e-27 91.6 3.1 1.6e-05 24.9 0.0 7.8 7 1 0 7 7 7 3 Ankyrin repeat Ank_4 PF13637.6 EDO07827.1 - 3.4e-27 94.5 0.4 1.7e-09 38.0 0.0 5.4 5 0 0 5 5 5 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EDO07827.1 - 8.6e-26 89.7 3.4 1e-07 32.1 0.0 5.2 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 EDO07827.1 - 3.2e-23 81.1 5.9 1.4e-05 25.3 0.0 7.3 7 0 0 7 7 7 3 Ankyrin repeat TPR_8 PF13181.6 EDO07827.1 - 2.7e-05 24.0 0.1 0.026 14.7 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDO07827.1 - 4.7e-05 23.2 0.0 0.094 12.9 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDO07827.1 - 0.021 15.1 0.0 0.046 14.0 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 EDO07827.1 - 0.059 13.2 0.0 0.31 11.0 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat E2_bind PF08825.10 EDO07828.1 - 0.11 12.7 0.0 0.4 10.9 0.0 1.9 2 0 0 2 2 2 0 E2 binding domain COPI_assoc PF08507.10 EDO07829.1 - 0.019 15.0 8.0 0.025 14.6 8.0 1.1 1 0 0 1 1 1 0 COPI associated protein CTV_P33 PF07184.11 EDO07829.1 - 0.02 14.0 0.1 0.025 13.6 0.1 1.1 1 0 0 1 1 1 0 Citrus tristeza virus P33 protein Anoctamin PF04547.12 EDO07829.1 - 1.5 7.5 4.6 2.1 7.1 2.6 1.8 2 0 0 2 2 2 0 Calcium-activated chloride channel CTP_transf_like PF01467.26 EDO07830.1 - 0.001 19.3 0.0 0.0046 17.2 0.0 2.1 1 1 0 1 1 1 1 Cytidylyltransferase-like FAD_syn PF06574.12 EDO07830.1 - 0.12 12.2 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 FAD synthetase DUF5049 PF16468.5 EDO07830.1 - 0.18 11.7 0.0 0.42 10.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5049) 7TM_GPCR_Sri PF10327.9 EDO07831.1 - 0.016 14.4 0.1 0.028 13.6 0.1 1.4 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sri zf-A20 PF01754.16 EDO07832.1 - 1.6e-12 47.1 9.2 1.6e-12 47.1 9.2 2.6 3 0 0 3 3 3 1 A20-like zinc finger zf-AN1 PF01428.16 EDO07832.1 - 1.8e-07 31.2 9.5 1.8e-07 31.2 9.5 2.4 3 1 0 3 3 3 1 AN1-like Zinc finger RrnaAD PF00398.20 EDO07834.1 - 3.6e-27 95.1 0.0 4e-27 94.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase YonK PF09642.10 EDO07835.1 - 0.0088 16.2 0.2 0.37 11.0 0.0 3.2 3 0 0 3 3 3 1 YonK protein MA3 PF02847.17 EDO07835.1 - 1.4 8.9 4.2 5.4 7.0 0.3 2.8 3 0 0 3 3 3 0 MA3 domain rpo30_N PF12410.8 EDO07835.1 - 3 7.7 7.1 6.1 6.8 0.1 2.9 2 1 1 3 3 3 0 Poxvirus DNA dependent RNA polymerase 30kDa subunit Chromate_transp PF02417.15 EDO07836.1 - 0.061 13.5 0.1 0.077 13.1 0.1 1.0 1 0 0 1 1 1 0 Chromate transporter WD40 PF00400.32 EDO07837.1 - 2.5e-14 53.4 2.6 0.00078 20.2 0.0 6.2 6 0 0 6 6 6 3 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 EDO07837.1 - 1e-12 48.4 0.7 1.7e-12 47.7 0.7 1.3 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 EDO07837.1 - 1e-05 25.7 0.0 1.4 9.3 0.0 4.5 4 1 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain DUF1230 PF06799.11 EDO07837.1 - 0.045 13.9 0.0 0.079 13.1 0.0 1.5 1 0 0 1 1 1 0 Conserved in the green lineage and diatoms 27 Glyco_hydro2_C5 PF18565.1 EDO07837.1 - 0.083 12.7 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 Glycoside hydrolase family 2 C-terminal domain 5 GDI PF00996.18 EDO07838.1 - 2.6e-28 98.7 0.2 1e-13 50.6 0.0 3.2 3 0 0 3 3 3 3 GDP dissociation inhibitor DAN PF03045.15 EDO07838.1 - 0.33 11.0 3.5 8.2 6.5 0.0 3.0 2 1 0 2 2 2 0 DAN domain SNRNP27 PF08648.12 EDO07841.1 - 3.4e-27 94.3 2.7 7.4e-27 93.2 2.7 1.6 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins SNF2_N PF00176.23 EDO07842.1 - 3e-42 144.6 0.1 1.3e-32 112.9 0.0 2.3 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EDO07842.1 - 1.6e-16 60.6 0.0 2.4e-15 56.9 0.0 2.6 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO07842.1 - 1.7e-07 31.4 0.0 4.4e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDO07842.1 - 8.4e-05 22.4 0.0 0.00019 21.3 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 EDO07842.1 - 0.014 14.6 0.0 0.035 13.3 0.0 1.6 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Cpn60_TCP1 PF00118.24 EDO07843.1 - 1e-167 558.7 3.0 1.2e-167 558.5 3.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Mo-co_dimer PF03404.16 EDO07844.1 - 0.066 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Mo-co oxidoreductase dimerisation domain Tubulin PF00091.25 EDO07846.1 - 3.6e-67 226.4 0.0 5.1e-67 225.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EDO07846.1 - 2.4e-50 169.9 0.1 4.8e-50 168.9 0.1 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EDO07846.1 - 0.034 13.8 0.0 0.1 12.3 0.0 1.8 1 0 0 1 1 1 0 Tubulin domain Ribosomal_L32e PF01655.18 EDO07847.1 - 1.3e-46 157.5 2.7 1.5e-46 157.3 2.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L32 RabGAP-TBC PF00566.18 EDO07848.1 - 3.6e-15 56.2 2.3 3.8e-15 56.1 0.1 2.0 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Enkurin PF13864.6 EDO07848.1 - 0.094 13.2 2.5 0.36 11.3 2.1 1.9 2 0 0 2 2 2 0 Calmodulin-binding Adaptin_N PF01602.20 EDO07849.1 - 1.6e-73 248.1 7.3 1.6e-73 248.1 7.3 1.5 2 0 0 2 2 2 1 Adaptin N terminal region Cnd1 PF12717.7 EDO07849.1 - 2.5e-09 37.4 0.8 1.5e-06 28.4 0.0 3.3 2 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EDO07849.1 - 1.8e-07 31.5 0.0 0.065 13.8 0.0 3.5 3 0 0 3 3 3 2 HEAT-like repeat HEAT PF02985.22 EDO07849.1 - 4.5e-06 26.5 0.1 0.11 12.8 0.0 4.8 4 0 0 4 4 4 1 HEAT repeat HEAT_2 PF13646.6 EDO07849.1 - 0.00021 21.6 0.1 0.092 13.1 0.0 3.1 3 0 0 3 3 3 1 HEAT repeats DUF913 PF06025.12 EDO07849.1 - 0.0018 17.3 0.0 0.0036 16.3 0.0 1.4 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) Vac14_Fab1_bd PF12755.7 EDO07849.1 - 0.063 13.9 1.1 19 6.0 0.2 2.9 2 1 0 2 2 2 0 Vacuolar 14 Fab1-binding region Cnd3 PF12719.7 EDO07849.1 - 0.59 9.3 5.3 0.41 9.8 0.2 2.8 3 0 0 3 3 3 0 Nuclear condensing complex subunits, C-term domain PH PF00169.29 EDO07850.1 - 0.083 13.4 0.0 0.21 12.1 0.0 1.6 1 0 0 1 1 1 0 PH domain SPC22 PF04573.12 EDO07851.1 - 2.1e-37 128.2 0.0 2.5e-37 128.0 0.0 1.0 1 0 0 1 1 1 1 Signal peptidase subunit Prefoldin_2 PF01920.20 EDO07852.1 - 2.1e-16 59.8 9.2 2.5e-16 59.6 9.2 1.1 1 0 0 1 1 1 1 Prefoldin subunit MIP-T3_C PF17749.1 EDO07852.1 - 0.0014 18.6 3.5 0.45 10.5 0.4 2.1 2 0 0 2 2 2 2 Microtubule-binding protein MIP-T3 C-terminal region Chibby PF14645.6 EDO07852.1 - 0.0053 17.2 1.2 0.007 16.8 1.2 1.2 1 0 0 1 1 1 1 Chibby family Spc24 PF08286.11 EDO07852.1 - 0.0094 16.2 9.2 0.046 14.0 2.1 2.1 2 0 0 2 2 2 1 Spc24 subunit of Ndc80 Takusan PF04822.13 EDO07852.1 - 0.015 15.2 9.5 0.24 11.3 0.8 2.2 2 0 0 2 2 2 0 Takusan CLZ PF16526.5 EDO07852.1 - 0.015 15.6 5.6 0.33 11.3 1.0 2.2 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Sec8_exocyst PF04048.14 EDO07852.1 - 0.016 15.1 3.7 1.1 9.1 0.6 2.1 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain Prefoldin PF02996.17 EDO07852.1 - 0.019 14.9 6.2 0.38 10.7 0.7 2.1 2 0 0 2 2 2 0 Prefoldin subunit HR1 PF02185.16 EDO07852.1 - 0.022 14.9 11.0 0.15 12.2 2.3 2.3 2 0 0 2 2 2 0 Hr1 repeat Csm1_N PF18504.1 EDO07852.1 - 0.024 15.0 7.3 0.45 10.9 1.2 2.2 2 0 0 2 2 2 0 Csm1 N-terminal domain CENP-H PF05837.12 EDO07852.1 - 0.038 14.4 3.2 2.8 8.4 0.3 2.1 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Seryl_tRNA_N PF02403.22 EDO07852.1 - 0.051 13.8 6.9 1.4 9.2 0.5 2.1 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain TMF_TATA_bd PF12325.8 EDO07852.1 - 0.053 13.7 10.6 0.84 9.9 1.2 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF406 PF04175.12 EDO07852.1 - 0.057 13.9 0.4 0.057 13.9 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF406) Sec20 PF03908.13 EDO07852.1 - 0.062 13.2 5.1 1 9.3 0.2 2.2 2 0 0 2 2 2 0 Sec20 Noelin-1 PF12308.8 EDO07852.1 - 0.08 12.9 2.0 0.22 11.5 0.5 2.0 1 1 1 2 2 2 0 Neurogenesis glycoprotein DUF1241 PF06840.11 EDO07852.1 - 0.087 12.5 2.8 0.14 11.8 2.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1241) DUF4140 PF13600.6 EDO07852.1 - 0.088 13.2 6.0 1.2 9.6 0.6 2.1 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) SKA2 PF16740.5 EDO07852.1 - 0.093 12.5 6.9 0.14 12.0 3.1 2.0 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 Baculo_PEP_C PF04513.12 EDO07852.1 - 0.11 12.5 2.4 0.19 11.8 2.4 1.4 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus PHM7_cyt PF14703.6 EDO07852.1 - 0.12 12.6 2.1 0.15 12.3 2.1 1.1 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter APG6_N PF17675.1 EDO07852.1 - 0.12 12.9 12.3 1.5 9.3 2.8 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region Adaptin_binding PF10199.9 EDO07852.1 - 0.13 12.9 4.2 5.6 7.6 0.3 2.2 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 Snapin_Pallidin PF14712.6 EDO07852.1 - 0.14 12.6 5.8 1.8 9.1 0.8 2.4 1 1 1 2 2 2 0 Snapin/Pallidin H-kinase_dim PF02895.14 EDO07852.1 - 0.16 12.4 7.9 2.5 8.6 0.9 2.2 2 0 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain DUF948 PF06103.11 EDO07852.1 - 0.18 12.1 0.8 20 5.5 0.1 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DP PF08781.10 EDO07852.1 - 0.22 11.4 11.4 0.66 9.9 0.6 2.5 2 1 0 2 2 2 0 Transcription factor DP DivIC PF04977.15 EDO07852.1 - 0.25 11.1 9.7 0.85 9.4 0.8 2.2 2 0 0 2 2 2 0 Septum formation initiator Med9 PF07544.13 EDO07852.1 - 0.25 11.4 5.2 2.6 8.2 0.1 2.3 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Ax_dynein_light PF10211.9 EDO07852.1 - 0.26 11.2 8.8 0.68 9.9 1.2 2.1 2 0 0 2 2 2 0 Axonemal dynein light chain Nas2_N PF18265.1 EDO07852.1 - 0.3 11.0 4.1 1.2 9.1 0.7 2.2 2 0 0 2 2 2 0 Nas2 N_terminal domain DUF3450 PF11932.8 EDO07852.1 - 0.33 10.2 7.7 1.1 8.5 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) zf-CpG_bind_C PF12269.8 EDO07852.1 - 0.33 10.7 5.2 4 7.2 0.9 2.1 2 0 0 2 2 2 0 CpG binding protein zinc finger C terminal domain EF-G-binding_N PF07299.11 EDO07852.1 - 0.37 11.4 4.5 0.29 11.7 0.7 2.1 2 0 0 2 2 2 0 Elongation factor G-binding protein, N-terminal V_ATPase_I PF01496.19 EDO07852.1 - 0.37 8.7 4.2 0.46 8.3 4.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family COG5 PF10392.9 EDO07852.1 - 0.44 10.7 7.1 3.4 7.9 0.3 2.1 1 1 1 2 2 2 0 Golgi transport complex subunit 5 Swi5 PF07061.11 EDO07852.1 - 0.45 10.6 6.1 2.8 8.1 1.2 2.4 2 0 0 2 2 2 0 Swi5 YlqD PF11068.8 EDO07852.1 - 0.51 10.7 9.6 1.2 9.5 1.8 2.1 1 1 1 2 2 2 0 YlqD protein DUF2730 PF10805.8 EDO07852.1 - 0.67 10.1 5.0 2.6 8.2 0.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) DivIVA PF05103.13 EDO07852.1 - 0.77 9.9 9.5 0.39 10.8 1.7 2.1 2 0 0 2 2 2 0 DivIVA protein Efg1 PF10153.9 EDO07852.1 - 0.8 10.1 7.5 3 8.3 7.5 1.8 1 1 0 1 1 1 0 rRNA-processing protein Efg1 Fib_alpha PF08702.10 EDO07852.1 - 1 9.6 6.2 1.2 9.3 0.4 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family SieB PF14163.6 EDO07852.1 - 1.2 8.6 5.0 0.53 9.8 1.0 1.9 2 0 0 2 2 2 0 Super-infection exclusion protein B YvrJ PF12841.7 EDO07852.1 - 1.6 8.3 3.3 9.2 5.9 0.2 2.3 2 0 0 2 2 2 0 YvrJ protein family YabA PF06156.13 EDO07852.1 - 2.1 9.1 10.4 8.1 7.1 1.7 2.1 1 1 1 2 2 2 0 Initiation control protein YabA XhlA PF10779.9 EDO07852.1 - 2.1 8.6 7.6 8 6.8 1.0 2.3 2 0 0 2 2 2 0 Haemolysin XhlA Vir_act_alpha_C PF10400.9 EDO07852.1 - 2.7 8.7 5.4 3 8.6 0.7 2.1 1 1 1 2 2 2 0 Virulence activator alpha C-term TMPIT PF07851.13 EDO07852.1 - 2.7 7.1 5.8 4.3 6.5 5.8 1.3 1 1 0 1 1 1 0 TMPIT-like protein MerR-DNA-bind PF09278.11 EDO07852.1 - 3.4 8.3 6.7 19 5.9 1.3 2.2 2 0 0 2 2 2 0 MerR, DNA binding Uteroglobin PF01099.17 EDO07852.1 - 3.8 7.9 6.1 3.5 8.0 1.5 2.5 1 1 0 2 2 2 0 Uteroglobin family M PF02370.16 EDO07852.1 - 9.1 7.2 17.8 0.76 10.5 3.0 3.2 3 0 0 3 3 2 0 M protein repeat Bac_DNA_binding PF00216.21 EDO07853.1 - 1.4e-20 73.3 0.3 1.8e-20 72.9 0.3 1.2 1 0 0 1 1 1 1 Bacterial DNA-binding protein HU-HIG PF18291.1 EDO07853.1 - 5.7e-10 39.4 0.2 7.2e-10 39.0 0.2 1.1 1 0 0 1 1 1 1 HU domain fused to wHTH, Ig, or Glycine-rich motif HU-CCDC81_euk_1 PF14908.6 EDO07853.1 - 0.0022 18.1 0.0 0.0035 17.5 0.0 1.3 1 0 0 1 1 1 1 CCDC81 eukaryotic HU domain 1 HU-CCDC81_bac_2 PF18175.1 EDO07853.1 - 0.0034 17.2 0.1 0.0064 16.3 0.1 1.4 1 0 0 1 1 1 1 CCDC81-like prokaryotic HU domain 2 Proteasom_PSMB PF10508.9 EDO07853.1 - 0.064 11.8 0.0 0.08 11.4 0.0 1.1 1 0 0 1 1 1 0 Proteasome non-ATPase 26S subunit HU-CCDC81_euk_2 PF18289.1 EDO07853.1 - 0.11 12.6 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 2 Pkinase PF00069.25 EDO07854.1 - 1.5e-27 96.7 0.0 1.9e-27 96.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO07854.1 - 3.2e-16 59.4 0.0 3.9e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDO07854.1 - 1.2e-08 34.2 0.0 1.6e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EDO07854.1 - 8.6e-05 22.6 0.0 0.0023 17.9 0.0 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EDO07854.1 - 0.021 13.8 0.2 0.021 13.8 0.2 1.6 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase RIO1 PF01163.22 EDO07854.1 - 0.088 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 RIO1 family SMC_N PF02463.19 EDO07856.1 - 6e-48 163.2 0.0 5.8e-47 160.0 0.0 2.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EDO07856.1 - 2.8e-23 82.5 0.0 1.5e-22 80.1 0.0 2.4 2 0 0 2 2 1 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 EDO07856.1 - 4.2e-14 53.5 1.8 4.2e-14 53.5 1.8 4.9 2 2 0 4 4 2 1 AAA domain AAA_21 PF13304.6 EDO07856.1 - 1.5e-13 51.2 1.6 6.4e-06 26.2 0.1 2.7 3 0 0 3 3 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EDO07856.1 - 1.9e-11 44.3 11.0 1e-08 35.4 4.3 3.6 2 2 0 2 2 2 2 AAA ATPase domain APG6_N PF17675.1 EDO07856.1 - 0.00019 22.0 69.2 0.0079 16.7 6.4 7.9 2 2 3 7 7 7 4 Apg6 coiled-coil region AAA_29 PF13555.6 EDO07856.1 - 0.0025 17.5 0.0 0.0052 16.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF5082 PF16888.5 EDO07856.1 - 0.0031 17.8 7.1 0.0031 17.8 7.1 6.9 4 1 3 8 8 7 1 Domain of unknown function (DUF5082) CENP-F_leu_zip PF10473.9 EDO07856.1 - 0.0042 17.1 11.7 0.0042 17.1 11.7 7.2 2 2 5 7 7 6 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ABC_tran PF00005.27 EDO07856.1 - 0.0055 17.2 17.3 0.015 15.8 0.1 5.0 4 3 1 5 5 5 2 ABC transporter ATG16 PF08614.11 EDO07856.1 - 0.0091 16.2 73.2 0.11 12.8 4.2 7.6 2 2 4 7 7 7 4 Autophagy protein 16 (ATG16) AAA_13 PF13166.6 EDO07856.1 - 0.011 14.5 54.2 0.071 11.8 12.7 4.7 3 2 2 5 5 5 0 AAA domain TMF_TATA_bd PF12325.8 EDO07856.1 - 0.011 16.0 4.5 0.011 16.0 4.5 8.4 3 2 6 9 9 9 0 TATA element modulatory factor 1 TATA binding DUF3450 PF11932.8 EDO07856.1 - 0.011 15.0 1.2 0.011 15.0 1.2 6.0 3 2 3 6 6 6 0 Protein of unknown function (DUF3450) AAA_25 PF13481.6 EDO07856.1 - 0.016 14.7 0.0 7.7 6.0 0.0 3.1 2 0 0 2 2 2 0 AAA domain Flagellin_C PF00700.21 EDO07856.1 - 0.034 14.5 0.1 0.034 14.5 0.1 4.2 5 0 0 5 5 4 0 Bacterial flagellin C-terminal helical region LPP PF04728.13 EDO07856.1 - 0.22 11.9 13.8 3.4 8.1 1.4 6.4 6 0 0 6 6 4 0 Lipoprotein leucine-zipper DUF948 PF06103.11 EDO07856.1 - 0.23 11.8 27.0 1.7 9.0 0.2 6.9 7 2 1 8 8 6 0 Bacterial protein of unknown function (DUF948) AAA_27 PF13514.6 EDO07856.1 - 0.55 9.8 0.0 0.55 9.8 0.0 5.1 6 0 0 6 6 5 0 AAA domain DUF724 PF05266.14 EDO07856.1 - 0.63 9.8 56.2 0.066 13.0 2.2 6.3 2 2 2 6 6 6 0 Protein of unknown function (DUF724) GAS PF13851.6 EDO07856.1 - 1.6 8.0 64.3 0.14 11.5 10.4 6.3 2 2 0 5 5 5 0 Growth-arrest specific micro-tubule binding DUF1664 PF07889.12 EDO07856.1 - 2.7 8.0 47.8 0.048 13.7 2.6 8.7 2 2 8 11 11 11 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 EDO07856.1 - 5 5.9 71.8 0.015 14.2 10.0 5.3 3 2 1 5 5 5 0 Spc7 kinetochore protein Ribosomal_S26e PF01283.19 EDO07858.1 - 4.3e-47 159.0 8.6 5.2e-47 158.8 8.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e SRP19 PF01922.17 EDO07858.1 - 0.013 16.4 0.1 0.023 15.7 0.1 1.5 1 1 0 1 1 1 0 SRP19 protein AAA PF00004.29 EDO07860.1 - 1.4e-13 51.4 0.0 3.1e-13 50.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EDO07860.1 - 2.7e-13 50.0 0.0 1e-12 48.2 0.0 1.9 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 EDO07860.1 - 1.4e-09 38.3 0.0 3.3e-09 37.0 0.0 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA_30 PF13604.6 EDO07860.1 - 7.7e-07 29.0 0.0 1.5e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EDO07860.1 - 9.9e-06 25.5 0.2 7e-05 22.7 0.1 2.5 2 1 0 2 2 2 1 AAA domain Rad17 PF03215.15 EDO07860.1 - 2.9e-05 24.1 0.0 6.2e-05 23.0 0.0 1.6 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 EDO07860.1 - 3.1e-05 24.3 0.1 0.00021 21.6 0.1 2.3 2 1 0 2 2 1 1 AAA domain AAA_5 PF07728.14 EDO07860.1 - 5.9e-05 23.1 0.0 0.00018 21.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 EDO07860.1 - 0.0001 22.6 0.0 0.00024 21.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 EDO07860.1 - 0.00022 21.5 0.0 0.00058 20.1 0.0 1.8 1 0 0 1 1 1 1 AAA C-terminal domain DEAD PF00270.29 EDO07860.1 - 0.0011 18.7 0.7 0.44 10.3 0.0 2.9 2 2 1 3 3 3 1 DEAD/DEAH box helicase AAA_16 PF13191.6 EDO07860.1 - 0.0014 19.0 0.0 0.01 16.2 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EDO07860.1 - 0.0018 18.1 0.0 0.0042 16.8 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain PhoH PF02562.16 EDO07860.1 - 0.0051 16.3 0.6 0.36 10.2 0.0 2.3 1 1 1 2 2 2 1 PhoH-like protein ResIII PF04851.15 EDO07860.1 - 0.0053 16.8 0.0 0.89 9.5 0.0 2.4 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 EDO07860.1 - 0.0062 15.8 0.0 0.0097 15.2 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) SNF2_N PF00176.23 EDO07860.1 - 0.013 14.3 0.0 0.019 13.7 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain AAA_3 PF07726.11 EDO07860.1 - 0.028 14.3 0.0 0.079 12.8 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 EDO07860.1 - 0.031 14.0 0.1 0.18 11.5 0.1 2.1 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 EDO07860.1 - 0.038 13.7 0.0 0.07 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 EDO07860.1 - 0.042 13.1 0.0 0.079 12.1 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 EDO07860.1 - 0.045 13.1 0.2 0.26 10.6 0.1 2.2 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EDO07860.1 - 0.051 13.7 0.0 0.15 12.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EDO07860.1 - 0.053 13.8 0.0 0.15 12.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain GRDB PF07355.12 EDO07860.1 - 0.053 12.8 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) Hydin_ADK PF17213.3 EDO07860.1 - 0.065 13.5 0.1 0.12 12.6 0.1 1.4 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain AAA_25 PF13481.6 EDO07860.1 - 0.066 12.8 0.0 0.18 11.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 EDO07860.1 - 0.084 12.3 0.1 0.4 10.1 0.1 2.0 1 1 0 1 1 1 0 Bacterial TniB protein AAA_23 PF13476.6 EDO07860.1 - 0.19 12.2 0.1 0.65 10.5 0.1 1.9 1 1 0 1 1 1 0 AAA domain ubiquitin PF00240.23 EDO07861.1 - 0.0041 16.9 0.0 0.0062 16.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Mt_ATP-synt_B PF05405.14 EDO07862.1 - 0.00065 19.4 3.2 0.0012 18.5 3.2 1.4 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF445 PF04286.12 EDO07862.1 - 0.06 13.1 0.5 0.085 12.6 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF445) RNA_pol PF00940.19 EDO07863.1 - 1.4e-139 465.5 0.0 4.1e-139 464.0 0.0 1.8 1 1 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 EDO07863.1 - 5.6e-21 75.3 0.8 6.2e-19 68.6 0.8 2.9 1 1 0 1 1 1 1 DNA-directed RNA polymerase N-terminal Beta-APP PF03494.13 EDO07864.1 - 0.4 10.5 4.8 0.95 9.4 4.8 1.6 1 0 0 1 1 1 0 Beta-amyloid peptide (beta-APP) Gly-zipper_YMGG PF13441.6 EDO07864.1 - 2.1 8.2 21.4 0.16 11.8 13.3 2.3 2 0 0 2 2 2 0 YMGG-like Gly-zipper GPI2 PF06432.11 EDO07864.1 - 7.7 5.9 8.7 32 3.9 8.7 1.8 1 1 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase zf-C3HC4_3 PF13920.6 EDO07865.1 - 7.1e-11 41.8 14.9 1.6e-10 40.7 14.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDO07865.1 - 0.00036 20.3 15.0 0.00036 20.3 15.0 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 RPA_interact_M PF14767.6 EDO07865.1 - 0.0068 16.9 1.2 2.9 8.5 0.0 2.7 2 0 0 2 2 2 2 Replication protein A interacting middle Tudor_3 PF18115.1 EDO07865.1 - 0.058 13.2 0.2 1.4 8.8 0.0 2.4 2 0 0 2 2 2 0 DNA repair protein Crb2 Tudor domain zf-RING_5 PF14634.6 EDO07865.1 - 0.064 13.2 17.4 0.18 11.8 17.4 1.8 1 0 0 1 1 1 0 zinc-RING finger domain UPF0242 PF06785.11 EDO07865.1 - 0.12 12.5 0.8 0.24 11.5 0.8 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Snf7 PF03357.21 EDO07866.1 - 3.6e-18 65.7 14.6 8e-18 64.6 14.7 1.7 1 1 0 1 1 1 1 Snf7 Tex_YqgF PF16921.5 EDO07866.1 - 0.026 15.0 0.7 0.057 13.9 0.4 1.7 1 1 0 1 1 1 0 Tex protein YqgF-like domain NleF_casp_inhib PF16809.5 EDO07866.1 - 0.092 12.7 2.6 0.15 12.0 2.1 1.6 1 1 0 1 1 1 0 NleF caspase inhibitor CCP_MauG PF03150.14 EDO07866.1 - 0.11 13.1 1.9 0.37 11.4 1.0 1.8 1 1 1 2 2 2 0 Di-haem cytochrome c peroxidase SUI1 PF01253.22 EDO07867.1 - 1.6e-23 83.0 0.3 2e-23 82.7 0.3 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF3395 PF11875.8 EDO07867.1 - 0.055 13.4 0.0 0.064 13.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3395) GIDA PF01134.22 EDO07868.1 - 4.3e-140 467.2 0.0 8.3e-140 466.3 0.0 1.4 2 0 0 2 2 2 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 EDO07868.1 - 2.1e-48 165.3 0.0 1.4e-47 162.6 0.0 2.2 1 1 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.7 EDO07868.1 - 5.5e-07 29.3 2.6 1.1e-06 28.3 2.6 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDO07868.1 - 2.7e-06 26.8 4.4 3.6e-05 23.2 4.5 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EDO07868.1 - 5.3e-06 25.8 5.6 0.00032 19.9 2.5 2.3 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.12 EDO07868.1 - 0.00015 20.9 2.1 0.036 13.1 0.6 2.3 2 0 0 2 2 2 2 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 EDO07868.1 - 0.0003 20.2 0.3 0.0023 17.3 0.3 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EDO07868.1 - 0.00033 19.5 3.3 0.026 13.2 1.4 3.2 3 0 0 3 3 3 1 HI0933-like protein Pyr_redox PF00070.27 EDO07868.1 - 0.00048 20.6 0.3 0.0018 18.8 0.3 2.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDO07868.1 - 0.0038 16.5 0.0 0.076 12.3 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EDO07868.1 - 0.051 13.1 1.8 0.61 9.6 0.4 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EDO07868.1 - 0.065 13.5 1.4 0.2 11.9 1.0 2.1 2 0 0 2 2 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 EDO07868.1 - 0.098 11.9 0.3 0.2 10.8 0.3 1.4 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.6 EDO07868.1 - 0.15 12.1 0.1 0.15 12.1 0.1 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding Trp_halogenase PF04820.14 EDO07868.1 - 0.26 10.1 3.4 0.28 10.0 0.4 2.0 2 0 0 2 2 2 0 Tryptophan halogenase C2 PF00168.30 EDO07869.1 - 5e-09 36.4 0.6 1.5e-06 28.4 0.1 3.4 3 0 0 3 3 3 2 C2 domain ArsR PF09824.9 EDO07869.1 - 0.13 11.8 1.6 0.22 11.1 0.3 1.9 2 0 0 2 2 2 0 ArsR transcriptional regulator VESA1_N PF12785.7 EDO07870.1 - 6.1e-22 78.2 18.6 5e-13 48.8 0.1 4.2 2 1 2 4 4 4 3 Variant erythrocyte surface antigen-1 RRP7 PF12923.7 EDO07871.1 - 2.6e-07 30.8 0.0 3.7e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain DUF3501 PF12007.8 EDO07871.1 - 0.11 12.4 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3501) PCI PF01399.27 EDO07872.1 - 9.4e-09 35.7 0.2 2.7e-08 34.3 0.1 1.9 2 0 0 2 2 2 1 PCI domain TPR_2 PF07719.17 EDO07872.1 - 0.29 11.3 0.8 0.59 10.4 0.3 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat VESA1_N PF12785.7 EDO07873.1 - 1.5e-20 73.7 28.2 1.9e-11 43.7 0.0 3.7 3 1 1 4 4 4 3 Variant erythrocyte surface antigen-1 FTCD_C PF04961.12 EDO07873.1 - 0.18 11.5 0.0 0.39 10.5 0.0 1.5 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase VESA1_N PF12785.7 EDO07874.1 - 5.7e-200 665.1 32.6 5.7e-200 665.1 32.6 3.0 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 SMBP PF16785.5 EDO07874.1 - 8.3 6.7 8.3 5.9 7.2 1.2 2.8 2 0 0 2 2 2 0 Small metal-binding protein Pkinase PF00069.25 EDO07877.1 - 9.4e-49 166.1 0.0 1.1e-48 165.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO07877.1 - 8.7e-37 126.8 0.0 1.2e-36 126.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDO07877.1 - 3.1e-08 32.8 0.1 4.4e-08 32.3 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EDO07877.1 - 8.5e-06 25.3 0.0 1.3e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EDO07877.1 - 9.9e-05 22.4 0.1 0.093 12.6 0.7 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EDO07877.1 - 0.0012 18.3 0.1 0.002 17.5 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Abhydrolase_1 PF00561.20 EDO07878.1 - 1.5e-05 24.7 0.0 0.00027 20.7 0.0 2.5 2 1 0 2 2 2 1 alpha/beta hydrolase fold Ndr PF03096.14 EDO07878.1 - 4.6e-05 22.3 0.0 7e-05 21.7 0.0 1.4 1 1 0 1 1 1 1 Ndr family Hydrolase_4 PF12146.8 EDO07878.1 - 0.0002 20.7 0.0 0.0062 15.8 0.0 2.2 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DUF1057 PF06342.12 EDO07878.1 - 0.00078 18.6 0.0 0.0012 17.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_6 PF12697.7 EDO07878.1 - 0.0016 19.0 0.0 0.0024 18.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family PUF PF00806.19 EDO07879.1 - 3e-15 54.9 5.2 0.00028 20.4 0.2 6.0 6 0 0 6 6 6 5 Pumilio-family RNA binding repeat DUF2854 PF11016.8 EDO07879.1 - 0.11 12.5 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2854) LCM PF04072.14 EDO07880.1 - 1.7e-15 57.4 0.0 7.4e-15 55.4 0.0 1.7 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase MTS PF05175.14 EDO07880.1 - 0.00019 21.0 0.0 0.00027 20.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 EDO07880.1 - 0.095 12.0 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_25 PF13649.6 EDO07880.1 - 0.17 12.6 0.0 0.3 11.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain POB3_N PF17292.2 EDO07881.1 - 3.7e-24 85.0 0.3 2.5e-20 72.7 0.1 2.8 2 1 0 2 2 2 2 POB3-like N-terminal PH domain Rtt106 PF08512.12 EDO07881.1 - 1.3e-23 83.2 5.5 3.1e-22 78.8 0.3 3.8 3 1 1 4 4 4 1 Histone chaperone Rttp106-like SSrecog PF03531.14 EDO07881.1 - 2.1e-17 62.8 0.7 6.4e-17 61.2 0.0 2.3 2 0 0 2 2 2 1 Structure-specific recognition protein (SSRP1) BTRD1 PF17660.1 EDO07881.1 - 0.14 12.0 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial tandem repeat domain 1 NOA36 PF06524.12 EDO07881.1 - 0.36 10.1 12.6 0.48 9.7 12.6 1.2 1 0 0 1 1 1 0 NOA36 protein PPP4R2 PF09184.11 EDO07881.1 - 2 7.9 11.3 3.1 7.3 11.3 1.3 1 0 0 1 1 1 0 PPP4R2 Ribosomal_L1 PF00687.21 EDO07882.1 - 4e-41 141.0 0.8 5e-41 140.7 0.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Pox_Ag35 PF03286.14 EDO07883.1 - 0.035 13.9 20.7 0.046 13.5 20.7 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Pkinase PF00069.25 EDO07885.1 - 1.2e-61 208.3 0.0 1.8e-61 207.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO07885.1 - 2.3e-30 105.7 0.0 4.1e-30 104.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDO07885.1 - 7e-06 25.5 0.0 1.2e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EDO07885.1 - 0.0057 16.0 0.0 1.1 8.5 0.0 2.2 2 0 0 2 2 2 2 Kinase-like FTA2 PF13095.6 EDO07885.1 - 0.067 12.8 0.0 0.29 10.7 0.0 1.8 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 WD40 PF00400.32 EDO07886.1 - 1.1e-05 26.1 0.1 0.24 12.3 0.0 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat PQQ_3 PF13570.6 EDO07886.1 - 0.037 14.5 5.2 0.25 11.9 0.0 3.6 4 0 0 4 4 4 0 PQQ-like domain PQQ_2 PF13360.6 EDO07886.1 - 0.063 12.8 0.1 0.17 11.4 0.1 1.6 1 1 0 1 1 1 0 PQQ-like domain WD40 PF00400.32 EDO07887.1 - 3.5e-09 37.1 8.7 0.0019 19.0 0.0 5.1 4 2 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 EDO07887.1 - 0.0042 15.8 1.7 0.35 9.4 0.2 2.5 1 1 2 3 3 3 2 Nucleoporin Nup120/160 RRM_1 PF00076.22 EDO07888.1 - 3.9e-06 26.6 0.0 8.2e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RcsD_ABL PF16359.5 EDO07889.1 - 0.0054 16.8 0.0 0.017 15.3 0.0 1.8 1 0 0 1 1 1 1 RcsD-ABL domain DUF1383 PF07134.11 EDO07889.1 - 0.038 13.1 0.0 0.069 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1383) Aldo_ket_red PF00248.21 EDO07890.1 - 4.1e-57 193.6 0.0 6.2e-57 193.0 0.0 1.3 1 0 0 1 1 1 1 Aldo/keto reductase family Biotin_lipoyl PF00364.22 EDO07891.1 - 6.5e-15 54.7 0.7 1.1e-14 54.0 0.5 1.4 1 1 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EDO07891.1 - 1.5e-05 24.7 2.0 0.046 13.5 0.2 2.2 1 1 1 2 2 2 2 Biotin-lipoyl like MCR_C PF04609.12 EDO07892.1 - 0.05 12.7 1.6 0.12 11.4 1.6 1.6 1 0 0 1 1 1 0 Methyl-coenzyme M reductase operon protein C L31 PF09784.9 EDO07892.1 - 2 8.9 7.6 4 7.9 0.3 3.4 2 1 1 3 3 3 0 Mitochondrial ribosomal protein L31 Gp-FAR-1 PF05823.12 EDO07892.1 - 4.6 7.6 13.1 1.6 9.0 4.8 3.6 1 1 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) SOAR PF16533.5 EDO07893.1 - 0.83 9.7 5.6 1.2 9.1 4.3 1.9 1 1 1 2 2 2 0 STIM1 Orai1-activating region YuiB PF14068.6 EDO07894.1 - 0.016 15.8 0.0 1.5 9.4 0.0 3.0 2 0 0 2 2 2 0 Putative membrane protein Ribosomal_L12_N PF16320.5 EDO07895.1 - 3.9e-17 61.7 2.9 7.1e-17 60.9 2.9 1.4 1 0 0 1 1 1 1 Ribosomal protein L7/L12 dimerisation domain Ribosomal_L12 PF00542.19 EDO07895.1 - 2.8e-06 27.6 1.9 3.9e-06 27.1 0.4 1.9 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_60s PF00428.19 EDO07895.1 - 0.011 16.3 1.2 0.011 16.3 1.2 1.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein Tom22 PF04281.13 EDO07896.1 - 4.3e-08 33.0 0.1 5e-08 32.8 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 CinA PF02464.17 EDO07896.1 - 0.03 13.9 0.0 0.039 13.5 0.0 1.2 1 0 0 1 1 1 0 Competence-damaged protein DUF4064 PF13273.6 EDO07896.1 - 0.072 13.4 0.0 0.079 13.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) zf-U1 PF06220.12 EDO07897.1 - 3.1e-18 65.2 2.4 4.4e-18 64.8 2.4 1.2 1 0 0 1 1 1 1 U1 zinc finger Tfb2_C PF18307.1 EDO07898.1 - 0.025 15.0 0.1 1.6 9.2 0.0 2.6 2 0 0 2 2 2 0 Transcription factor Tfb2 (p52) C-terminal domain Adenine_glyco PF03352.13 EDO07898.1 - 0.095 12.5 0.1 0.16 11.7 0.1 1.3 1 0 0 1 1 1 0 Methyladenine glycosylase ArfGap PF01412.18 EDO07899.1 - 0.0031 17.6 0.8 0.0052 16.8 0.8 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PHM7_cyt PF14703.6 EDO07900.1 - 0.08 13.2 0.0 0.99 9.6 0.0 2.1 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Nudc_N PF14050.6 EDO07901.1 - 1.7e-21 75.9 1.3 3e-21 75.2 1.3 1.4 1 0 0 1 1 1 1 N-terminal conserved domain of Nudc. CS PF04969.16 EDO07901.1 - 5.6e-12 46.5 0.1 1.4e-11 45.3 0.1 1.7 1 0 0 1 1 1 1 CS domain UQ_con PF00179.26 EDO07902.1 - 1.6e-48 164.0 0.0 1.8e-48 163.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EDO07902.1 - 0.0057 16.9 0.1 0.0077 16.5 0.1 1.6 1 1 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 EDO07902.1 - 0.015 15.0 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B RRM_1 PF00076.22 EDO07903.1 - 5.9e-16 58.1 0.0 9.7e-16 57.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Arf PF00025.21 EDO07905.1 - 1.8e-17 63.4 0.0 2.7e-17 62.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EDO07905.1 - 1.2e-07 31.3 0.0 1.7e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EDO07905.1 - 0.0018 18.3 0.1 0.038 14.1 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase MFS_1 PF07690.16 EDO07906.1 - 2.5e-20 72.7 50.2 1.4e-19 70.2 48.4 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDO07906.1 - 2.1e-07 30.2 18.5 2.1e-07 30.2 18.5 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_4 PF06779.14 EDO07906.1 - 7e-05 22.3 8.7 7e-05 22.3 8.7 1.9 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 EDO07906.1 - 2 6.6 35.2 0.023 13.0 0.9 4.7 1 1 3 5 5 5 0 Organic Anion Transporter Polypeptide (OATP) family CLTH PF10607.9 EDO07907.1 - 5.5e-23 81.5 0.0 9.3e-23 80.8 0.0 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain ATP_bind_2 PF03668.15 EDO07907.1 - 0.09 12.1 0.2 0.16 11.2 0.2 1.3 1 0 0 1 1 1 0 P-loop ATPase protein family ER_lumen_recept PF00810.18 EDO07908.1 - 8.7e-35 120.7 8.1 8.7e-35 120.7 8.1 2.2 3 0 0 3 3 3 1 ER lumen protein retaining receptor Colicin_im PF03857.13 EDO07908.1 - 0.21 11.5 0.2 0.21 11.5 0.2 2.8 2 2 0 3 3 3 0 Colicin immunity protein PIG-U PF06728.13 EDO07909.1 - 6.6e-11 41.9 10.9 7.8e-11 41.6 10.9 1.1 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U RIBIOP_C PF04950.12 EDO07910.1 - 1.6e-73 247.7 0.0 2.7e-73 247.0 0.0 1.3 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EDO07910.1 - 1.6e-21 76.2 0.0 5.4e-21 74.5 0.0 2.0 2 0 0 2 2 1 1 AARP2CN (NUC121) domain RsgA_GTPase PF03193.16 EDO07910.1 - 6.4e-05 22.9 0.0 0.00016 21.6 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 EDO07910.1 - 0.00017 22.0 0.2 0.00058 20.3 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain GTP_EFTU PF00009.27 EDO07910.1 - 0.00028 20.5 0.0 0.0059 16.2 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 EDO07910.1 - 0.00076 20.0 0.2 0.003 18.1 0.0 2.1 2 0 0 2 2 1 1 ABC transporter RNA_helicase PF00910.22 EDO07910.1 - 0.0014 19.0 0.0 0.0063 16.9 0.0 2.3 1 0 0 1 1 1 1 RNA helicase MMR_HSR1 PF01926.23 EDO07910.1 - 0.0022 18.1 0.1 0.011 15.8 0.1 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase NACHT PF05729.12 EDO07910.1 - 0.0034 17.3 0.0 0.0068 16.3 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_33 PF13671.6 EDO07910.1 - 0.0038 17.4 0.1 0.038 14.2 0.1 2.5 2 0 0 2 2 2 1 AAA domain Septin PF00735.18 EDO07910.1 - 0.023 14.0 0.0 0.045 13.0 0.0 1.4 1 0 0 1 1 1 0 Septin AAA PF00004.29 EDO07910.1 - 0.032 14.6 0.0 0.079 13.4 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EDO07910.1 - 0.035 14.0 0.0 0.08 12.9 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain cobW PF02492.19 EDO07910.1 - 0.04 13.5 0.1 0.076 12.6 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.14 EDO07910.1 - 0.04 13.9 0.3 0.12 12.3 0.0 1.9 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) KAP_NTPase PF07693.14 EDO07910.1 - 0.041 13.1 0.0 0.084 12.1 0.0 1.5 1 0 0 1 1 1 0 KAP family P-loop domain NTPase_1 PF03266.15 EDO07910.1 - 0.046 13.6 0.1 0.1 12.5 0.1 1.6 1 0 0 1 1 1 0 NTPase AAA_18 PF13238.6 EDO07910.1 - 0.057 14.0 3.4 0.12 12.9 0.1 2.9 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.6 EDO07910.1 - 0.067 13.5 0.0 0.22 11.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EDO07910.1 - 0.073 12.8 0.0 0.2 11.4 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.6 EDO07910.1 - 0.08 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EDO07910.1 - 0.08 12.1 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_7 PF12775.7 EDO07910.1 - 0.085 12.4 0.0 0.22 11.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 EDO07910.1 - 0.091 12.8 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 EDO07910.1 - 0.1 12.4 0.2 0.28 10.9 0.1 1.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein ATPase_2 PF01637.18 EDO07910.1 - 0.11 12.4 0.0 0.29 11.0 0.0 1.8 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea zf-CW PF07496.15 EDO07911.1 - 1.9e-16 59.8 7.3 3.5e-16 59.0 7.3 1.5 1 0 0 1 1 1 1 CW-type Zinc Finger EF-hand_7 PF13499.6 EDO07912.1 - 3.9e-21 75.3 2.4 1.8e-10 41.1 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EDO07912.1 - 9.4e-20 68.6 4.3 1e-07 30.9 0.1 3.8 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EDO07912.1 - 1.7e-16 58.7 2.2 1.6e-05 24.5 0.0 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 EDO07912.1 - 2e-15 56.4 4.3 8.6e-09 35.1 0.2 3.1 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EDO07912.1 - 4.2e-05 22.8 3.7 0.021 14.3 0.2 3.8 4 0 0 4 4 4 2 EF hand EF-hand_9 PF14658.6 EDO07912.1 - 0.0023 18.2 1.1 2.1 8.8 0.1 3.1 1 1 2 3 3 3 1 EF-hand domain EF-hand_11 PF08976.11 EDO07912.1 - 0.0079 17.1 0.4 0.84 10.5 0.0 2.2 1 1 1 2 2 2 1 EF-hand domain EF-hand_14 PF17959.1 EDO07912.1 - 0.023 15.0 0.3 5.3 7.5 0.0 2.2 1 1 1 2 2 2 0 EF-hand domain SurA_N_3 PF13624.6 EDO07912.1 - 0.029 14.2 0.4 0.29 10.9 0.2 2.0 1 1 1 2 2 2 0 SurA N-terminal domain SUB1_ProdP9 PF18213.1 EDO07912.1 - 0.044 13.6 0.3 0.095 12.6 0.2 1.6 1 1 0 1 1 1 0 SUB1 protease Prodomain ProdP9 Acetyltransf_11 PF13720.6 EDO07912.1 - 0.11 13.0 0.1 0.46 11.0 0.0 2.0 2 1 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 SPARC_Ca_bdg PF10591.9 EDO07912.1 - 0.11 12.8 0.0 19 5.6 0.0 2.2 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EDO07912.1 - 0.12 12.4 1.1 2.6 8.1 0.2 2.5 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand IspD PF01128.19 EDO07913.1 - 1.3e-35 123.2 0.0 8.5e-34 117.2 0.0 2.3 2 0 0 2 2 2 2 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Ribophorin_I PF04597.14 EDO07914.1 - 6e-18 65.3 2.2 6.7e-18 65.1 2.2 1.1 1 0 0 1 1 1 1 Ribophorin I ASF1_hist_chap PF04729.13 EDO07914.1 - 0.023 14.6 0.8 0.52 10.3 0.1 3.0 1 1 1 2 2 2 0 ASF1 like histone chaperone Asp PF00026.23 EDO07915.1 - 1.1e-67 228.7 0.0 3.5e-61 207.3 0.0 2.3 1 1 1 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDO07915.1 - 3.8e-13 50.1 0.2 1.2e-09 38.6 0.1 3.2 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal DUF1819 PF08849.11 EDO07916.1 - 0.065 13.0 0.2 0.15 11.8 0.2 1.6 1 0 0 1 1 1 0 Putative inner membrane protein (DUF1819) V-SNARE PF05008.15 EDO07916.1 - 0.082 13.3 1.6 0.21 12.0 1.6 1.7 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus TSNAXIP1_N PF15739.5 EDO07916.1 - 0.13 12.6 3.0 0.86 10.0 0.1 2.6 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus dsDNA_bind PF01984.20 EDO07918.1 - 7.2e-20 71.3 11.1 8.7e-20 71.1 11.1 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain EF-hand_7 PF13499.6 EDO07918.1 - 0.047 14.1 0.0 0.078 13.4 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair Selenoprotein_S PF06936.11 EDO07918.1 - 6.8 6.5 10.8 0.93 9.3 3.2 2.1 1 1 1 2 2 2 0 Selenoprotein S (SelS) FDC-SP PF15215.6 EDO07919.1 - 0.11 13.1 1.3 0.34 11.5 1.3 1.8 1 0 0 1 1 1 0 Follicular dendritic cell secreted peptide Ribosomal_S27e PF01667.17 EDO07920.1 - 6.1e-25 86.7 5.4 7.6e-25 86.4 5.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 TF_Zn_Ribbon PF08271.12 EDO07920.1 - 0.00092 18.7 1.5 0.002 17.6 0.9 1.8 2 0 0 2 2 2 1 TFIIB zinc-binding Ribosomal_L24e PF01246.20 EDO07921.1 - 2.6e-26 91.6 1.1 2.6e-26 91.6 1.1 1.9 2 0 0 2 2 2 1 Ribosomal protein L24e NHS PF15273.6 EDO07921.1 - 0.0096 15.1 1.5 0.011 14.9 1.5 1.0 1 0 0 1 1 1 1 NHS-like Spc7 PF08317.11 EDO07921.1 - 0.033 13.1 1.9 0.037 12.9 1.9 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF2188 PF09954.9 EDO07921.1 - 1.8 8.8 5.2 4.7 7.4 5.2 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2188) DCP2 PF05026.13 EDO07922.1 - 3.6e-18 65.7 1.3 2.4e-17 63.0 0.4 2.2 2 0 0 2 2 2 1 Dcp2, box A domain NUDIX PF00293.28 EDO07922.1 - 7.3e-12 45.5 0.0 1.3e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain CPSase_L_D2 PF02786.17 EDO07923.1 - 2.4e-83 278.8 0.0 5e-63 212.4 0.0 2.9 2 1 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 EDO07923.1 - 4.9e-45 152.5 0.0 1e-44 151.4 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 EDO07923.1 - 1e-43 149.3 0.0 3e-43 147.8 0.0 1.8 2 0 0 2 2 2 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.19 EDO07923.1 - 5.9e-34 117.0 0.0 1.1e-33 116.2 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATPgrasp_Ter PF15632.6 EDO07923.1 - 1.3e-11 44.3 0.1 4.5e-06 26.4 0.1 2.6 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.22 EDO07923.1 - 2e-10 40.5 0.0 2e-05 24.2 0.1 2.4 2 0 0 2 2 2 2 ATP-grasp domain Peptidase_C26 PF07722.13 EDO07923.1 - 5.2e-10 39.4 0.1 3.7e-08 33.4 0.1 2.5 1 1 0 1 1 1 1 Peptidase C26 Dala_Dala_lig_C PF07478.13 EDO07923.1 - 5.5e-08 32.6 0.7 6.4e-05 22.6 0.0 3.1 3 0 0 3 3 3 2 D-ala D-ala ligase C-terminus MGS PF02142.22 EDO07923.1 - 2.6e-06 27.5 0.0 2.8e-05 24.2 0.0 2.8 1 1 0 1 1 1 1 MGS-like domain DJ-1_PfpI PF01965.24 EDO07923.1 - 0.013 15.4 0.1 2.5 7.9 0.0 3.2 3 0 0 3 3 3 0 DJ-1/PfpI family RimK PF08443.11 EDO07923.1 - 0.033 13.8 0.0 2.7 7.5 0.0 2.5 2 0 0 2 2 2 0 RimK-like ATP-grasp domain GARS_A PF01071.19 EDO07923.1 - 0.17 11.7 0.0 0.38 10.5 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Pkinase PF00069.25 EDO07924.1 - 7.3e-62 209.1 0.0 1e-61 208.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO07924.1 - 3.9e-27 95.2 0.0 5.8e-27 94.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO07924.1 - 0.00062 19.2 0.0 0.002 17.5 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EDO07924.1 - 0.00064 19.1 0.0 0.0011 18.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDO07924.1 - 0.0028 17.6 0.2 0.0078 16.2 0.2 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDO07924.1 - 0.017 14.7 0.0 0.031 13.9 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF1679 PF07914.11 EDO07924.1 - 0.044 12.6 0.3 0.51 9.1 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1679) CSN8_PSD8_EIF3K PF10075.9 EDO07925.1 - 5.3e-14 52.4 0.4 1.2e-13 51.3 0.4 1.6 1 1 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 EDO07925.1 - 0.00035 20.1 0.9 0.00047 19.6 0.5 1.4 2 0 0 2 2 2 1 SAC3/GANP family zf-RING_2 PF13639.6 EDO07926.1 - 3.8e-10 39.9 8.0 9.2e-10 38.7 8.0 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EDO07926.1 - 2.3e-07 30.4 2.6 5.8e-07 29.1 2.6 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EDO07926.1 - 1.4e-06 28.1 6.7 2.9e-06 27.0 6.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDO07926.1 - 2.1e-06 27.5 4.2 4.8e-06 26.3 4.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDO07926.1 - 2.7e-06 27.2 6.7 5.6e-06 26.1 6.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EDO07926.1 - 1.5e-05 25.2 6.8 3.6e-05 24.0 6.8 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EDO07926.1 - 5.7e-05 23.0 5.9 0.00011 22.0 5.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EDO07926.1 - 0.00011 22.0 6.8 0.00024 20.9 6.8 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EDO07926.1 - 0.00079 19.4 3.0 0.0017 18.3 3.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 EDO07926.1 - 0.0025 17.4 5.1 0.0058 16.2 5.1 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 EDO07926.1 - 0.0045 16.7 4.1 0.011 15.5 4.1 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 EDO07926.1 - 0.18 11.8 4.8 0.62 10.2 4.8 2.0 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 EDO07926.1 - 1.2 9.4 8.6 8.4 6.6 8.6 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain zf-P11 PF03854.14 EDO07926.1 - 1.8 8.3 6.6 6.3 6.5 6.6 2.1 1 1 0 1 1 1 0 P-11 zinc finger RINGv PF12906.7 EDO07926.1 - 2.5 8.3 9.1 5.4 7.2 9.1 1.6 1 0 0 1 1 1 0 RING-variant domain WD40 PF00400.32 EDO07928.1 - 2.2e-05 25.1 5.2 0.0053 17.6 0.1 5.3 6 1 0 6 6 6 1 WD domain, G-beta repeat Proteasome PF00227.26 EDO07928.1 - 0.08 12.4 0.0 0.24 10.9 0.0 1.7 2 0 0 2 2 2 0 Proteasome subunit DUF4860 PF16152.5 EDO07929.1 - 0.09 12.6 0.4 0.15 11.9 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4860) MMtag PF10159.9 EDO07930.1 - 8.3e-22 77.3 1.0 1.3e-21 76.7 1.0 1.3 1 0 0 1 1 1 1 Multiple myeloma tumor-associated HCR PF07111.12 EDO07930.1 - 0.12 10.4 0.0 0.14 10.1 0.0 1.1 1 0 0 1 1 1 0 Alpha helical coiled-coil rod protein (HCR) WD40 PF00400.32 EDO07931.1 - 3.5e-05 24.5 5.3 0.0056 17.5 0.1 5.3 6 1 0 6 6 6 1 WD domain, G-beta repeat Proteasome PF00227.26 EDO07931.1 - 0.08 12.4 0.0 0.23 11.0 0.0 1.7 2 0 0 2 2 2 0 Proteasome subunit TRP_2 PF08344.11 EDO07932.1 - 0.11 12.7 0.2 0.76 10.0 0.0 2.4 3 0 0 3 3 3 0 Transient receptor ion channel II ABC_tran_CTD PF16326.5 EDO07933.1 - 0.067 13.4 0.5 0.15 12.3 0.5 1.7 1 0 0 1 1 1 0 ABC transporter C-terminal domain Paf67 PF10255.9 EDO07936.1 - 6.6e-127 423.9 4.6 7.9e-127 423.6 4.6 1.1 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 EDO07936.1 - 0.084 13.0 0.1 0.39 11.0 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat IBN_N PF03810.19 EDO07937.1 - 5e-07 29.5 0.2 2.4e-06 27.4 0.1 2.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain RIX1 PF08167.12 EDO07937.1 - 1.3e-06 28.3 4.1 4.8e-06 26.4 0.4 3.2 4 0 0 4 4 4 1 rRNA processing/ribosome biogenesis Syntaxin PF00804.25 EDO07938.1 - 1.1e-19 70.9 1.1 1.5e-19 70.5 1.1 1.2 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.19 EDO07938.1 - 0.00012 22.0 0.4 0.00053 19.9 0.2 2.3 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.6 EDO07938.1 - 0.00033 21.0 2.8 0.00033 21.0 2.8 2.4 2 2 0 2 2 2 1 Syntaxin-like protein DUF948 PF06103.11 EDO07938.1 - 0.36 11.1 3.0 1.1 9.6 0.1 2.6 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) RSS_P20 PF11757.8 EDO07938.1 - 0.75 10.3 5.2 0.87 10.1 0.9 2.9 2 2 1 3 3 3 0 Suppressor of RNA silencing P21-like N-terminal domain ISG65-75 PF11727.8 EDO07938.1 - 1.5 8.0 7.3 0.14 11.4 2.4 1.7 2 0 0 2 2 2 0 Invariant surface glycoprotein FliE PF02049.18 EDO07938.1 - 8.6 6.6 8.9 1.7 8.8 0.4 3.2 5 0 0 5 5 5 0 Flagellar hook-basal body complex protein FliE WD40 PF00400.32 EDO07939.1 - 1.1e-09 38.8 1.7 8.8e-07 29.5 0.0 3.7 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO07939.1 - 0.0054 17.0 0.0 1.6 9.1 0.0 3.5 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDO07939.1 - 0.15 10.6 0.0 0.24 10.0 0.0 1.3 1 0 0 1 1 1 0 Nucleoporin Nup120/160 AP2 PF00847.20 EDO07940.1 - 5.4e-11 42.6 1.6 8.2e-11 42.0 1.6 1.3 1 0 0 1 1 1 1 AP2 domain CC2D2AN-C2 PF15625.6 EDO07941.1 - 0.011 15.5 0.0 0.028 14.2 0.0 1.6 1 1 0 1 1 1 0 CC2D2A N-terminal C2 domain CRT-like PF08627.10 EDO07942.1 - 2.6e-48 164.7 21.8 3e-48 164.5 21.8 1.0 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like CAP PF00188.26 EDO07943.1 - 3.3e-14 53.8 0.5 6.7e-14 52.8 0.5 1.5 1 1 0 1 1 1 1 Cysteine-rich secretory protein family Ribosomal_S14 PF00253.21 EDO07944.1 - 2.5e-14 52.8 2.7 2.8e-14 52.6 2.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DUF4428 PF14471.6 EDO07944.1 - 0.0099 15.8 0.1 0.012 15.5 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4428) Cytochrom_c3_2 PF14537.6 EDO07944.1 - 0.051 14.0 0.3 0.062 13.8 0.3 1.1 1 0 0 1 1 1 0 Cytochrome c3 DnaJ-X PF14308.6 EDO07945.1 - 1.6e-45 155.1 2.2 1.6e-45 155.1 2.2 1.8 2 0 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 EDO07945.1 - 2e-22 79.1 0.4 4.1e-22 78.1 0.4 1.6 1 0 0 1 1 1 1 DnaJ domain ATG_C PF09333.11 EDO07945.1 - 0.00065 20.0 0.1 0.0038 17.5 0.0 2.4 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain Peptidase_M16_C PF05193.21 EDO07948.1 - 1.5e-27 96.8 0.0 2.7e-27 96.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EDO07948.1 - 6.1e-27 94.4 0.0 8e-26 90.8 0.0 2.1 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Tmemb_40 PF10160.9 EDO07948.1 - 0.088 12.2 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 Predicted membrane protein ATG16 PF08614.11 EDO07949.1 - 8.9e-05 22.8 57.2 0.037 14.2 10.9 4.2 2 2 1 3 3 3 3 Autophagy protein 16 (ATG16) Spc7 PF08317.11 EDO07949.1 - 0.00041 19.3 54.4 0.0052 15.7 16.0 3.4 1 1 1 3 3 3 2 Spc7 kinetochore protein HOOK PF05622.12 EDO07949.1 - 0.0014 16.9 10.2 0.0014 16.9 10.2 3.3 1 1 3 4 4 4 2 HOOK protein Laminin_I PF06008.14 EDO07949.1 - 0.0042 16.8 6.5 0.0042 16.8 6.5 4.2 2 1 2 4 4 4 1 Laminin Domain I FAM76 PF16046.5 EDO07949.1 - 0.033 13.5 41.5 0.028 13.8 5.3 4.1 1 1 3 4 4 4 0 FAM76 protein Vac_Fusion PF02346.16 EDO07949.1 - 0.046 13.4 0.6 0.046 13.4 0.6 4.6 4 2 0 4 4 4 0 Chordopoxvirus multifunctional envelope protein A27 Fez1 PF06818.15 EDO07949.1 - 0.12 12.9 51.3 6 7.3 15.2 4.1 1 1 2 3 3 3 0 Fez1 Filament PF00038.21 EDO07949.1 - 0.4 10.2 52.4 2.7 7.5 10.4 3.9 2 2 2 4 4 4 0 Intermediate filament protein GAS PF13851.6 EDO07949.1 - 0.55 9.6 48.3 3.4 7.0 17.6 4.7 1 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding DUF3584 PF12128.8 EDO07949.1 - 1.1 6.7 49.3 0.12 9.9 10.7 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF3584) Atg14 PF10186.9 EDO07949.1 - 1.7 7.7 43.7 1.5 7.9 11.9 3.3 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Dynamitin PF04912.14 EDO07949.1 - 2.1 7.6 41.8 0.0095 15.3 22.1 2.6 1 1 1 2 2 2 0 Dynamitin BLOC1_2 PF10046.9 EDO07949.1 - 2.8 8.3 33.5 0.12 12.7 4.2 5.3 2 1 3 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 APG6_N PF17675.1 EDO07949.1 - 2.9 8.4 58.3 4.3 7.9 24.1 4.3 2 2 1 3 3 3 0 Apg6 coiled-coil region Leu_zip PF15294.6 EDO07949.1 - 3.4 7.1 42.5 0.45 10.0 13.3 3.8 1 1 3 4 4 4 0 Leucine zipper TMF_TATA_bd PF12325.8 EDO07949.1 - 6 7.1 58.1 0.041 14.1 14.8 5.5 2 2 3 5 5 5 0 TATA element modulatory factor 1 TATA binding DUF1664 PF07889.12 EDO07949.1 - 6.4 6.8 34.6 0.21 11.6 2.9 5.2 3 2 1 4 4 4 0 Protein of unknown function (DUF1664) Tropomyosin_1 PF12718.7 EDO07949.1 - 7.1 6.8 53.3 0.92 9.7 5.9 4.6 1 1 3 5 5 5 0 Tropomyosin like DUF4200 PF13863.6 EDO07949.1 - 9.6 6.6 47.9 2.7 8.4 9.6 4.1 2 2 0 3 3 3 0 Domain of unknown function (DUF4200) DUF2203 PF09969.9 EDO07949.1 - 9.8 6.9 29.5 0.78 10.5 2.7 4.8 2 1 2 4 4 4 0 Uncharacterized conserved protein (DUF2203) zf_CCCH_4 PF18345.1 EDO07950.1 - 2.4e-08 33.8 18.6 8.1e-06 25.7 8.1 4.5 3 1 0 3 3 3 2 Zinc finger domain zf-CCCH PF00642.24 EDO07950.1 - 6.2e-07 29.2 20.9 1.5e-05 24.8 4.1 5.1 3 2 1 4 4 4 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EDO07950.1 - 0.00023 20.9 5.0 0.00023 20.9 5.0 3.6 5 0 0 5 5 5 1 CCCH-type zinc finger Torus PF16131.5 EDO07950.1 - 0.0059 17.3 2.3 0.0059 17.3 2.3 3.5 2 1 2 4 4 4 2 Torus domain zf-CCCH_2 PF14608.6 EDO07950.1 - 0.17 12.4 19.5 0.2 12.2 1.5 4.1 4 0 0 4 4 4 0 RNA-binding, Nab2-type zinc finger DEAD PF00270.29 EDO07951.1 - 4.3e-30 104.8 0.0 1.4e-29 103.2 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO07951.1 - 1.7e-16 60.5 0.0 3.6e-16 59.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SPRY PF00622.28 EDO07951.1 - 1.4e-13 51.0 0.4 2.6e-13 50.1 0.4 1.4 1 0 0 1 1 1 1 SPRY domain ResIII PF04851.15 EDO07951.1 - 0.17 11.9 0.0 5 7.1 0.0 2.5 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit G10 PF01125.17 EDO07952.1 - 2.4e-65 218.7 1.3 2.7e-65 218.6 1.3 1.0 1 0 0 1 1 1 1 G10 protein Archease PF01951.16 EDO07954.1 - 8e-40 136.3 0.0 9.9e-40 136.0 0.0 1.1 1 0 0 1 1 1 1 Archease protein family (MTH1598/TM1083) Ribosomal_L27A PF00828.19 EDO07955.1 - 1.7e-24 86.9 0.7 1.1e-23 84.3 0.2 2.3 2 0 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Takusan PF04822.13 EDO07955.1 - 0.051 13.5 0.3 0.14 12.0 0.3 1.8 1 0 0 1 1 1 0 Takusan Lipase_GDSL_3 PF14606.6 EDO07955.1 - 0.18 12.0 0.0 0.35 11.0 0.0 1.4 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Ribosomal_L17 PF01196.19 EDO07956.1 - 1.4e-21 77.2 0.6 1.8e-21 76.9 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L17 Defensin_1 PF00323.19 EDO07956.1 - 0.032 14.8 0.8 0.082 13.5 0.8 1.7 1 0 0 1 1 1 0 Mammalian defensin AFG1_ATPase PF03969.16 EDO07957.1 - 8.8e-71 238.7 0.2 1e-68 231.9 0.0 2.1 2 0 0 2 2 2 2 AFG1-like ATPase Bac_DnaA PF00308.18 EDO07957.1 - 0.0011 18.9 0.0 0.0028 17.5 0.0 1.6 2 0 0 2 2 2 1 Bacterial dnaA protein AAA_29 PF13555.6 EDO07957.1 - 0.018 14.8 0.0 0.036 13.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.29 EDO07957.1 - 0.027 14.9 0.0 0.065 13.7 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 EDO07957.1 - 0.086 12.6 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein ABC_tran PF00005.27 EDO07957.1 - 0.095 13.2 0.0 1.7 9.1 0.0 2.6 2 1 0 3 3 3 0 ABC transporter AAA_22 PF13401.6 EDO07957.1 - 0.13 12.5 0.0 0.34 11.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain Chromo PF00385.24 EDO07958.1 - 1.1e-16 60.5 6.0 3.9e-13 49.1 0.5 2.5 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow PF01393.19 EDO07958.1 - 0.00034 20.7 0.1 0.15 12.2 0.0 3.2 3 0 0 3 3 3 1 Chromo shadow domain Ndc1_Nup PF09531.10 EDO07958.1 - 0.052 12.2 5.0 0.056 12.1 5.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Hid1 PF12722.7 EDO07958.1 - 0.099 10.8 6.1 0.11 10.6 6.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein LON_substr_bdg PF02190.16 EDO07959.1 - 3.7e-05 23.7 0.1 0.0001 22.3 0.0 1.7 2 0 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain Hydant_A_N PF05378.13 EDO07959.1 - 0.056 13.1 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase N-terminal region TnpW PF14202.6 EDO07959.1 - 0.088 12.6 0.1 0.088 12.6 0.1 1.7 2 0 0 2 2 2 0 Transposon-encoded protein TnpW PUB PF09409.10 EDO07960.1 - 0.00013 21.8 0.1 0.00068 19.5 0.1 2.1 2 0 0 2 2 2 1 PUB domain 7TMR-HDED PF07697.11 EDO07960.1 - 0.024 14.8 1.7 0.045 13.9 1.7 1.4 1 0 0 1 1 1 0 7TM-HD extracellular Baculo_p24 PF05073.12 EDO07960.1 - 0.041 13.7 0.7 1.4 8.7 0.0 2.6 1 1 1 2 2 2 0 Baculovirus P24 capsid protein XPC-binding PF09280.11 EDO07960.1 - 0.042 13.6 0.1 0.16 11.7 0.1 2.1 1 0 0 1 1 1 0 XPC-binding domain AbiJ_NTD4 PF18863.1 EDO07961.1 - 0.0084 16.6 0.4 0.0093 16.4 0.4 1.0 1 0 0 1 1 1 1 AbiJ N-terminal domain 4 DUF5615 PF18480.1 EDO07962.1 - 0.0071 16.1 0.1 0.015 15.1 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5615) WBS_methylT PF12589.8 EDO07963.1 - 2.9e-13 50.4 5.8 4.6e-13 49.7 5.8 1.3 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_25 PF13649.6 EDO07963.1 - 6e-10 39.7 0.0 1.4e-09 38.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDO07963.1 - 1.2e-09 38.7 0.0 2.2e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDO07963.1 - 3.6e-07 30.1 0.0 4.9e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDO07963.1 - 3.1e-05 24.6 0.0 7.8e-05 23.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 EDO07963.1 - 0.0029 17.2 0.0 0.0047 16.5 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_23 PF13489.6 EDO07963.1 - 0.0039 17.0 0.0 0.0079 16.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EDO07963.1 - 0.022 14.8 1.1 0.045 13.8 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain PCMT PF01135.19 EDO07963.1 - 0.043 13.6 0.2 0.084 12.6 0.0 1.5 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 EDO07963.1 - 0.067 12.7 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase small domain N6_N4_Mtase PF01555.18 EDO07963.1 - 0.093 12.4 0.7 0.49 10.1 0.0 2.2 2 1 0 2 2 2 0 DNA methylase U3_assoc_6 PF08640.11 EDO07964.1 - 7e-22 77.3 1.8 1.6e-21 76.2 1.8 1.6 1 0 0 1 1 1 1 U3 small nucleolar RNA-associated protein 6 LRR_9 PF14580.6 EDO07964.1 - 0.039 13.5 0.7 0.084 12.4 0.2 1.8 2 0 0 2 2 2 0 Leucine-rich repeat DnaJ PF00226.31 EDO07965.1 - 1e-14 54.4 1.8 1e-14 54.4 1.8 1.9 2 0 0 2 2 2 1 DnaJ domain IL17R_fnIII_D2 PF16578.5 EDO07965.1 - 1.5 9.4 4.4 11 6.6 0.1 2.8 2 1 1 3 3 3 0 Interleukin 17 receptor D UQ_con PF00179.26 EDO07966.1 - 7.1e-19 67.8 0.0 7.9e-19 67.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EDO07966.1 - 0.056 13.7 0.0 0.059 13.7 0.0 1.2 1 0 0 1 1 1 0 RWD domain NIF PF03031.18 EDO07967.1 - 4.6e-48 162.9 0.1 7.5e-48 162.2 0.1 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase FB_lectin PF07367.11 EDO07967.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Fungal fruit body lectin Hydrolase PF00702.26 EDO07967.1 - 0.2 11.9 0.0 0.35 11.1 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase RNA_pol_L_2 PF13656.6 EDO07968.1 - 1.7e-10 40.5 0.0 2.2e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Mcl1_mid PF12341.8 EDO07969.1 - 4.8e-28 98.4 0.0 1e-27 97.3 0.0 1.4 1 0 0 1 1 1 1 Minichromosome loss protein, Mcl1, middle region AP2 PF00847.20 EDO07972.1 - 8.7e-11 41.9 0.6 0.00027 21.1 0.0 2.5 2 0 0 2 2 2 2 AP2 domain WD40_3 PF15911.5 EDO07972.1 - 0.14 12.2 0.0 3.3 7.8 0.0 2.5 2 1 0 2 2 2 0 WD domain, G-beta repeat V-ATPase_H_C PF11698.8 EDO07973.1 - 6.9e-40 135.8 2.6 1.7e-39 134.5 0.2 2.7 3 0 0 3 3 3 1 V-ATPase subunit H V-ATPase_H_N PF03224.14 EDO07973.1 - 5.4e-35 121.2 0.6 7.5e-35 120.7 0.6 1.2 1 0 0 1 1 1 1 V-ATPase subunit H Arm PF00514.23 EDO07973.1 - 0.01 15.8 0.0 9.8 6.4 0.0 2.9 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat RED_N PF07808.13 EDO07974.1 - 1.7e-17 63.8 8.2 2.8e-16 59.8 8.2 2.4 1 1 0 1 1 1 1 RED-like protein N-terminal region RRM_1 PF00076.22 EDO07975.1 - 6.1e-17 61.2 0.2 2.7e-08 33.5 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDO07975.1 - 0.0011 18.7 0.0 0.73 9.7 0.0 2.3 2 0 0 2 2 2 2 Occluded RNA-recognition motif DUF4523 PF15023.6 EDO07975.1 - 0.068 13.0 0.0 0.76 9.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) DUF2838 PF10998.8 EDO07979.1 - 0.97 9.7 4.6 3.1 8.0 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2838) KH_6 PF15985.5 EDO07980.1 - 3.4e-11 43.3 0.0 5.9e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 KH domain YfkB PF08756.10 EDO07981.1 - 0.029 14.1 0.1 0.06 13.1 0.1 1.5 1 0 0 1 1 1 0 YfkB-like domain PHM7_cyt PF14703.6 EDO07982.1 - 0.0012 19.1 1.3 0.0012 19.1 1.3 2.4 2 1 0 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter DUF2203 PF09969.9 EDO07982.1 - 0.49 11.1 8.1 1.1 10.1 0.3 4.0 3 1 1 4 4 4 0 Uncharacterized conserved protein (DUF2203) DUF4047 PF13256.6 EDO07982.1 - 1.1 9.4 6.6 2.5 8.3 0.5 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) Casc1_N PF15927.5 EDO07982.1 - 6 6.5 9.4 0.52 10.0 2.1 2.8 2 1 1 3 3 3 0 Cancer susceptibility candidate 1 N-terminus DUF1664 PF07889.12 EDO07983.1 - 0.6 10.2 3.5 15 5.7 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) Arf PF00025.21 EDO07985.1 - 5.8e-74 247.3 0.2 6.8e-74 247.1 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EDO07985.1 - 2.6e-15 56.7 0.1 3.7e-15 56.2 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EDO07985.1 - 5e-14 52.1 0.0 6.6e-14 51.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EDO07985.1 - 6.1e-14 51.9 1.6 1e-08 34.8 0.3 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EDO07985.1 - 7.6e-13 48.4 0.0 8.4e-13 48.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EDO07985.1 - 3.1e-09 36.5 0.0 3.8e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDO07985.1 - 1.1e-05 25.4 0.1 1.8e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EDO07985.1 - 0.0028 17.0 0.2 0.0042 16.4 0.2 1.5 1 1 0 1 1 1 1 6-phosphofructo-2-kinase CRISPR_Cas2 PF09827.9 EDO07985.1 - 0.039 14.1 0.1 0.081 13.1 0.0 1.6 2 0 0 2 2 2 0 CRISPR associated protein Cas2 NACHT PF05729.12 EDO07985.1 - 0.076 12.9 0.1 0.47 10.3 0.0 1.9 2 0 0 2 2 2 0 NACHT domain AAA_33 PF13671.6 EDO07985.1 - 0.1 12.8 0.4 0.36 11.0 0.4 1.9 1 1 0 1 1 1 0 AAA domain HSP90 PF00183.18 EDO07986.1 - 1.1e-226 753.8 23.7 1.5e-226 753.3 23.7 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 EDO07986.1 - 1.3e-13 51.4 0.1 2.6e-13 50.4 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EDO07986.1 - 2.7e-11 43.5 0.3 7.3e-11 42.0 0.3 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ribosomal_S20p PF01649.18 EDO07986.1 - 0.015 15.9 0.7 0.015 15.9 0.7 3.1 3 0 0 3 3 3 0 Ribosomal protein S20 LOH1CR12 PF10158.9 EDO07986.1 - 0.048 13.7 0.6 0.13 12.2 0.2 2.0 2 0 0 2 2 2 0 Tumour suppressor protein HSP70 PF00012.20 EDO07987.1 - 6.8e-82 275.6 0.0 1.2e-81 274.7 0.0 1.4 2 0 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 EDO07987.1 - 1.1e-06 27.7 0.2 5.1e-06 25.5 0.1 1.9 2 0 0 2 2 2 1 MreB/Mbl protein BUD22 PF09073.10 EDO07987.1 - 0.013 14.8 2.2 0.019 14.4 2.2 1.1 1 0 0 1 1 1 0 BUD22 FUSC PF04632.12 EDO07987.1 - 5.7 5.3 6.5 8.4 4.8 5.3 1.6 1 1 0 2 2 2 0 Fusaric acid resistance protein family SCO1-SenC PF02630.14 EDO07988.1 - 5.4e-45 152.6 0.0 7e-45 152.2 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 EDO07988.1 - 2.2e-06 27.6 0.0 4.1e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EDO07988.1 - 0.0026 17.5 0.0 0.15 11.7 0.0 2.1 2 0 0 2 2 2 2 Redoxin Kdo PF06293.14 EDO07990.1 - 1e-12 47.9 0.3 1.9e-12 47.0 0.3 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EDO07990.1 - 4.7e-12 45.8 0.6 5.6e-12 45.6 0.6 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EDO07990.1 - 1.6e-11 44.6 0.4 0.0001 22.3 0.1 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 EDO07990.1 - 3.9e-11 42.9 0.3 5.3e-11 42.5 0.2 1.3 1 1 0 1 1 1 1 RIO1 family Pkinase_Tyr PF07714.17 EDO07990.1 - 1.6e-09 37.5 0.4 1.9e-09 37.2 0.4 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 EDO07990.1 - 6.2e-05 22.7 0.1 0.0013 18.3 0.1 2.0 1 1 1 2 2 2 2 Choline/ethanolamine kinase EcKinase PF02958.20 EDO07990.1 - 0.00053 19.4 0.0 0.00069 19.0 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase APH_6_hur PF04655.14 EDO07990.1 - 0.045 13.1 0.2 1.3 8.3 0.1 2.5 1 1 1 2 2 2 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase RNA_pol_N PF01194.17 EDO07992.1 - 1.9e-31 108.1 0.8 2.3e-31 107.9 0.8 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.12 EDO07992.1 - 0.011 15.9 0.4 0.016 15.4 0.4 1.3 1 1 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) YHS PF04945.13 EDO07993.1 - 0.1 12.7 0.8 0.21 11.7 0.8 1.4 1 0 0 1 1 1 0 YHS domain Ribosomal_L37e PF01907.19 EDO07994.1 - 1.6e-23 82.6 10.4 1.6e-23 82.6 10.4 1.6 2 0 0 2 2 2 1 Ribosomal protein L37e DZR PF12773.7 EDO07994.1 - 0.021 14.8 2.2 0.038 14.0 2.2 1.5 1 0 0 1 1 1 0 Double zinc ribbon HypA PF01155.19 EDO07994.1 - 0.046 13.7 0.4 0.063 13.3 0.4 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_5 PF14634.6 EDO07994.1 - 0.43 10.6 6.1 0.26 11.3 3.6 1.8 2 0 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EDO07994.1 - 3.7 7.5 7.5 1.4 8.9 4.7 1.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) GCV_H PF01597.19 EDO07995.1 - 0.0013 18.6 0.0 0.0019 18.1 0.0 1.3 1 0 0 1 1 1 1 Glycine cleavage H-protein LPD39 PF18858.1 EDO07995.1 - 0.081 13.0 0.0 0.1 12.7 0.0 1.1 1 0 0 1 1 1 0 Large polyvalent protein associated domain 39 RSV_NS2 PF03113.14 EDO07997.1 - 0.096 12.7 0.1 8.1 6.5 0.0 2.7 3 0 0 3 3 3 0 Respiratory synctial virus non-structural protein NS2 NOG1_N PF17835.1 EDO07998.1 - 7.1e-47 159.3 0.4 1.3e-46 158.5 0.4 1.4 1 0 0 1 1 1 1 NOG1 N-terminal helical domain NOG1 PF06858.14 EDO07998.1 - 3e-26 91.0 0.1 7.3e-26 89.7 0.1 1.7 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) NOGCT PF08155.11 EDO07998.1 - 7.3e-20 70.7 0.1 1.9e-19 69.3 0.1 1.8 1 0 0 1 1 1 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.23 EDO07998.1 - 6.8e-17 61.6 0.0 1.3e-16 60.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDO07998.1 - 7.2e-10 38.6 0.0 1.4e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EDO07998.1 - 0.0091 16.1 1.3 5 7.2 0.0 3.4 3 1 1 4 4 4 1 Dynamin family AIG1 PF04548.16 EDO07998.1 - 0.029 13.7 0.0 0.06 12.7 0.0 1.5 1 0 0 1 1 1 0 AIG1 family RsgA_GTPase PF03193.16 EDO07998.1 - 0.054 13.4 0.0 0.97 9.3 0.0 2.4 2 1 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 EDO07998.1 - 0.1 13.0 0.0 0.53 10.7 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.6 EDO07998.1 - 0.1 13.1 0.0 0.78 10.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain MMR_HSR1_Xtn PF16897.5 EDO07998.1 - 0.12 12.4 0.0 0.32 11.0 0.0 1.7 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain LRR_4 PF12799.7 EDO07999.1 - 1.4e-08 34.9 7.1 0.0092 16.4 0.8 4.6 4 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDO07999.1 - 1.8e-06 27.6 5.0 0.0013 18.4 0.4 3.5 4 0 0 4 4 4 2 Leucine rich repeat KASH_CCD PF14662.6 EDO08000.1 - 0.002 18.0 35.0 0.058 13.2 18.8 4.0 1 1 0 2 2 2 1 Coiled-coil region of CCDC155 or KASH TPR_MLP1_2 PF07926.12 EDO08000.1 - 0.0055 16.8 6.0 0.0055 16.8 6.0 3.9 2 1 1 3 3 2 1 TPR/MLP1/MLP2-like protein HAUS-augmin3 PF14932.6 EDO08000.1 - 0.022 14.3 30.7 0.07 12.7 3.6 3.1 2 1 1 3 3 3 0 HAUS augmin-like complex subunit 3 bZIP_1 PF00170.21 EDO08000.1 - 0.042 14.0 1.8 0.042 14.0 1.8 4.3 3 1 1 4 4 4 0 bZIP transcription factor SHE3 PF17078.5 EDO08000.1 - 0.053 13.2 25.8 0.32 10.7 17.9 3.2 2 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 ADIP PF11559.8 EDO08000.1 - 0.062 13.4 31.4 0.53 10.4 6.2 4.3 4 0 0 4 4 4 0 Afadin- and alpha -actinin-Binding Cep57_CLD_2 PF14197.6 EDO08000.1 - 0.073 13.2 0.5 0.073 13.2 0.5 5.2 5 1 1 6 6 6 0 Centrosome localisation domain of PPC89 HALZ PF02183.18 EDO08000.1 - 0.13 12.5 0.4 0.13 12.5 0.4 4.6 4 0 0 4 4 4 0 Homeobox associated leucine zipper UPF0242 PF06785.11 EDO08000.1 - 0.15 12.1 30.6 0.29 11.2 12.3 3.1 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus APG6_N PF17675.1 EDO08000.1 - 0.18 12.3 30.2 0.072 13.6 1.9 3.5 2 1 1 3 3 2 0 Apg6 coiled-coil region YabA PF06156.13 EDO08000.1 - 0.3 11.7 22.6 0.96 10.1 11.2 3.6 2 2 0 2 2 2 0 Initiation control protein YabA Het-C PF07217.11 EDO08000.1 - 0.31 9.5 9.9 0.012 14.2 2.8 2.0 1 1 1 2 2 2 0 Heterokaryon incompatibility protein Het-C Shugoshin_N PF07558.11 EDO08000.1 - 0.57 10.1 10.3 9.8 6.1 0.2 3.8 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region Mto2_bdg PF12808.7 EDO08000.1 - 0.72 10.2 10.9 1.6 9.1 1.1 2.8 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Jnk-SapK_ap_N PF09744.9 EDO08000.1 - 2.3 8.4 34.9 2.5 8.3 13.8 4.0 2 1 2 4 4 4 0 JNK_SAPK-associated protein-1 APC_N_CC PF16689.5 EDO08000.1 - 2.4 8.3 12.9 0.63 10.1 1.5 3.8 4 0 0 4 4 3 0 Coiled-coil N-terminus of APC, dimerisation domain DivIC PF04977.15 EDO08000.1 - 2.5 7.9 27.2 0.31 10.8 4.6 4.8 3 1 2 5 5 5 0 Septum formation initiator ZapB PF06005.12 EDO08000.1 - 3.6 8.1 34.5 0.25 11.8 3.8 4.2 3 1 1 4 4 3 0 Cell division protein ZapB Bap31_Bap29_C PF18035.1 EDO08000.1 - 7.7 6.6 15.5 0.84 9.7 0.2 3.8 3 1 0 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain GNAT_acetyltr_2 PF13718.6 EDO08001.1 - 2.7e-70 236.3 0.0 1.5e-49 168.5 0.0 2.3 1 1 1 2 2 2 2 GNAT acetyltransferase 2 Helicase_RecD PF05127.14 EDO08001.1 - 2.1e-51 174.3 0.0 3.6e-51 173.5 0.0 1.4 1 0 0 1 1 1 1 Helicase tRNA_bind_2 PF13725.6 EDO08001.1 - 4.2e-35 121.6 0.7 3.9e-34 118.4 0.0 2.1 2 0 0 2 2 2 1 Possible tRNA binding domain DUF1726 PF08351.11 EDO08001.1 - 3.8e-32 110.1 0.1 9.5e-32 108.8 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) ATP-synt_DE_N PF02823.16 EDO08003.1 - 1.9e-12 46.9 0.1 2.7e-12 46.4 0.1 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Ribosomal_L5 PF00281.19 EDO08004.1 - 0.054 13.8 0.0 0.098 13.0 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L5 DUF1449 PF07290.11 EDO08006.1 - 0.081 12.5 0.6 0.14 11.8 0.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1449) UNC-93 PF05978.16 EDO08006.1 - 0.087 12.5 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Ion channel regulatory protein UNC-93 TIC20 PF16166.5 EDO08007.1 - 1.9e-09 37.6 3.1 2.4e-09 37.2 3.1 1.1 1 0 0 1 1 1 1 Chloroplast import apparatus Tic20-like YCF90 PF17088.5 EDO08007.1 - 0.0095 15.3 0.4 0.016 14.5 0.4 1.4 1 1 0 1 1 1 1 Uncharacterised protein family Tmpp129 PF10272.9 EDO08007.1 - 0.29 10.4 0.4 0.4 9.9 0.4 1.2 1 0 0 1 1 1 0 Putative transmembrane protein precursor Ras PF00071.22 EDO08008.1 - 9.9e-58 194.3 0.2 1.2e-57 194.0 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO08008.1 - 1.4e-36 125.4 0.1 2.2e-36 124.7 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO08008.1 - 8.3e-18 64.4 0.1 1.1e-17 64.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDO08008.1 - 4e-09 36.2 0.1 4.9e-09 35.9 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EDO08008.1 - 7e-07 28.8 0.1 1.1e-06 28.2 0.1 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EDO08008.1 - 1.2e-05 24.9 0.2 0.00037 20.1 0.0 2.4 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDO08008.1 - 4.9e-05 23.4 0.1 8.1e-05 22.7 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDO08008.1 - 0.00046 19.7 0.3 0.0077 15.8 0.3 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EDO08008.1 - 0.0034 17.3 0.1 0.018 15.0 0.1 2.1 2 1 0 2 2 2 1 RsgA GTPase AAA_24 PF13479.6 EDO08008.1 - 0.0082 15.9 0.6 0.16 11.7 0.7 2.2 1 1 0 1 1 1 1 AAA domain TniB PF05621.11 EDO08008.1 - 0.01 15.2 0.0 0.029 13.8 0.0 1.7 2 1 0 2 2 2 0 Bacterial TniB protein IFT46_B_C PF12317.8 EDO08008.1 - 0.011 15.5 0.8 0.53 10.0 0.1 2.8 1 1 0 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal TetR_C_16 PF17920.1 EDO08008.1 - 0.018 15.3 0.0 0.11 12.8 0.0 1.9 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain ATP_bind_3 PF01171.20 EDO08009.1 - 1.9e-11 44.1 0.0 6.4e-10 39.1 0.0 2.3 2 0 0 2 2 2 1 PP-loop family zn-ribbon_14 PF16503.5 EDO08009.1 - 1.4e-05 24.5 2.3 1.4e-05 24.5 2.3 3.4 3 0 0 3 3 3 1 Zinc-ribbon PAPS_reduct PF01507.19 EDO08009.1 - 0.013 15.5 0.0 3.1 7.8 0.0 2.5 2 0 0 2 2 2 0 Phosphoadenosine phosphosulfate reductase family Oxidoreduct_C PF16490.5 EDO08009.1 - 0.11 12.1 0.1 0.18 11.5 0.1 1.2 1 0 0 1 1 1 0 Putative oxidoreductase C terminal domain NTR2 PF15458.6 EDO08009.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Nineteen complex-related protein 2 ATP_bind_3 PF01171.20 EDO08011.1 - 1.1e-10 41.5 0.0 2.1e-10 40.7 0.0 1.4 1 1 0 1 1 1 1 PP-loop family tRNA_Me_trans PF03054.16 EDO08011.1 - 0.1 11.3 0.0 0.39 9.5 0.0 1.8 2 0 0 2 2 2 0 tRNA methyl transferase ATP_bind_3 PF01171.20 EDO08013.1 - 1.1e-10 41.5 0.0 2.1e-10 40.7 0.0 1.4 1 1 0 1 1 1 1 PP-loop family tRNA_Me_trans PF03054.16 EDO08013.1 - 0.1 11.3 0.0 0.39 9.5 0.0 1.8 2 0 0 2 2 2 0 tRNA methyl transferase TTL PF03133.15 EDO08017.1 - 1.5e-43 149.0 0.0 2.5e-43 148.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 EDO08017.1 - 2.7e-11 43.2 0.2 7e-07 28.7 0.0 3.3 2 1 1 3 3 3 3 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 EDO08017.1 - 7.2e-07 28.7 0.1 0.00064 19.1 0.0 2.4 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp RimK PF08443.11 EDO08017.1 - 5.8e-05 22.8 0.1 0.052 13.1 0.0 2.8 3 0 0 3 3 3 2 RimK-like ATP-grasp domain Dala_Dala_lig_C PF07478.13 EDO08017.1 - 0.0041 16.7 0.1 2.5 7.6 0.0 2.9 3 0 0 3 3 3 2 D-ala D-ala ligase C-terminus ATP-grasp_4 PF13535.6 EDO08017.1 - 0.0064 16.1 0.0 0.026 14.1 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp domain CPSase_L_D2 PF02786.17 EDO08017.1 - 0.038 13.5 0.0 0.11 11.9 0.0 1.8 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Dimerisation2 PF16864.5 EDO08017.1 - 0.11 12.5 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 Dimerisation domain ATP-grasp PF02222.22 EDO08017.1 - 0.11 12.0 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain Prenyltrans PF00432.21 EDO08018.1 - 7.8e-34 115.1 13.0 4.5e-06 26.3 0.1 5.9 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 EDO08018.1 - 0.12 11.5 0.0 3.8 6.5 0.0 2.7 3 1 0 3 3 3 0 Squalene-hopene cyclase N-terminal domain EF-hand_1 PF00036.32 EDO08019.1 - 1e-07 31.0 0.9 0.011 15.3 0.1 3.3 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EDO08019.1 - 6.6e-07 28.8 0.4 0.12 12.4 0.1 3.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 EDO08019.1 - 4.5e-05 22.7 1.0 0.003 17.0 0.2 3.3 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.6 EDO08019.1 - 0.00012 22.4 1.0 0.0082 16.6 0.2 3.5 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.6 EDO08019.1 - 0.059 13.2 0.1 2.9 7.8 0.0 3.1 2 0 0 2 2 2 0 EF-hand domain pair YccV-like PF08755.11 EDO08019.1 - 0.11 13.0 0.1 0.35 11.4 0.1 1.9 1 0 0 1 1 1 0 Hemimethylated DNA-binding protein YccV like PITH PF06201.13 EDO08020.1 - 3e-24 86.0 0.0 3.8e-24 85.6 0.0 1.1 1 0 0 1 1 1 1 PITH domain RRM_1 PF00076.22 EDO08022.1 - 3.5e-35 119.7 0.1 4.7e-17 61.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDO08022.1 - 6.1e-05 22.8 0.0 0.0065 16.3 0.0 2.4 2 0 0 2 2 2 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EDO08022.1 - 0.00029 20.8 0.0 0.12 12.4 0.0 2.5 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EDO08022.1 - 0.016 15.2 1.6 0.58 10.2 0.0 2.8 3 0 0 3 3 3 0 RNA binding motif RRM_7 PF16367.5 EDO08022.1 - 0.093 12.9 0.0 0.78 9.9 0.0 2.5 2 1 0 2 2 2 0 RNA recognition motif MerC PF03203.14 EDO08023.1 - 2e-14 54.1 8.1 2.6e-14 53.7 8.1 1.1 1 0 0 1 1 1 1 MerC mercury resistance protein DUF4491 PF14898.6 EDO08023.1 - 0.014 15.8 2.8 0.014 15.8 2.8 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4491) DUF2101 PF09874.9 EDO08023.1 - 0.065 12.9 3.6 0.082 12.6 3.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2101) DUF3852 PF12963.7 EDO08023.1 - 0.094 13.1 0.9 0.094 13.1 0.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3852) Chromate_transp PF02417.15 EDO08023.1 - 0.6 10.2 8.8 0.76 9.9 8.8 1.1 1 0 0 1 1 1 0 Chromate transporter SRP1_TIP1 PF00660.17 EDO08024.1 - 0.12 12.5 0.6 1.1 9.3 0.0 2.4 2 1 0 3 3 3 0 Seripauperin and TIP1 family ATP-synt_C PF00137.21 EDO08025.1 - 6.3e-09 36.0 7.6 1e-08 35.4 7.6 1.3 1 0 0 1 1 1 1 ATP synthase subunit C Ribosomal_L18A PF01775.17 EDO08026.1 - 2e-50 169.9 0.1 2.5e-50 169.6 0.1 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A Ribosomal_L18 PF17135.4 EDO08027.1 - 3e-84 281.1 1.4 3.4e-84 280.9 1.4 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 EDO08027.1 - 0.065 13.9 0.1 0.1 13.3 0.1 1.5 1 1 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A ATP-synt_D PF01813.17 EDO08028.1 - 2.9e-56 190.4 1.6 3.3e-56 190.2 1.6 1.0 1 0 0 1 1 1 1 ATP synthase subunit D Ribosomal_S6e PF01092.19 EDO08029.1 - 1.2e-54 183.5 0.0 2.6e-54 182.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S6e CS PF04969.16 EDO08030.1 - 0.00021 22.2 0.0 0.00036 21.5 0.0 1.4 1 0 0 1 1 1 1 CS domain RAP PF08373.10 EDO08031.1 - 5.5e-07 29.6 0.0 1.2e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 RAP domain Leo1 PF04004.13 EDO08032.1 - 7.4e-11 42.2 0.0 1.2e-10 41.5 0.0 1.4 1 1 0 1 1 1 1 Leo1-like protein DUF3084 PF11283.8 EDO08033.1 - 0.12 12.4 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3084) E1-E2_ATPase PF00122.20 EDO08034.1 - 0.0036 16.8 1.7 0.015 14.8 0.0 2.7 2 0 0 2 2 2 1 E1-E2 ATPase SF3b10 PF07189.11 EDO08035.1 - 4.6e-33 113.2 0.5 5.7e-33 112.9 0.5 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) Med14 PF08638.11 EDO08036.1 - 3.4e-26 91.8 0.0 5.1e-26 91.3 0.0 1.2 1 0 0 1 1 1 1 Mediator complex subunit MED14 AP2 PF00847.20 EDO08037.1 - 4.3e-12 46.1 0.4 0.0001 22.5 0.0 2.5 2 0 0 2 2 2 2 AP2 domain TPR_14 PF13428.6 EDO08038.1 - 3.6e-28 95.8 15.2 8.8e-05 23.0 0.1 11.7 5 2 7 12 12 11 7 Tetratricopeptide repeat TPR_19 PF14559.6 EDO08038.1 - 5.2e-22 78.1 1.0 7.9e-08 32.7 0.0 7.2 5 3 2 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.17 EDO08038.1 - 7.3e-18 63.2 9.5 0.0029 17.6 0.0 10.2 11 0 0 11 11 11 4 Tetratricopeptide repeat HAT PF02184.16 EDO08038.1 - 2.7e-14 52.8 37.0 1.9e-05 24.5 0.0 9.2 12 0 0 12 12 9 4 HAT (Half-A-TPR) repeat TPR_8 PF13181.6 EDO08038.1 - 2.7e-14 52.1 3.0 1.1 9.7 0.0 9.1 10 0 0 10 10 9 4 Tetratricopeptide repeat Suf PF05843.14 EDO08038.1 - 1.5e-13 51.4 16.0 1.4e-05 25.3 2.9 7.4 2 2 4 6 6 6 3 Suppressor of forked protein (Suf) TPR_17 PF13431.6 EDO08038.1 - 3.9e-12 45.7 4.9 0.011 16.0 0.0 7.8 8 2 0 8 8 7 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDO08038.1 - 4e-10 39.1 7.3 0.31 10.9 0.0 7.4 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 EDO08038.1 - 4.5e-10 40.0 15.9 0.013 16.1 0.0 6.6 5 2 1 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 EDO08038.1 - 4.9e-09 36.4 9.9 0.041 14.2 0.0 7.4 6 3 0 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 EDO08038.1 - 2e-08 33.7 1.2 0.0019 17.8 0.1 4.6 5 0 0 5 5 5 2 TPR repeat TPR_7 PF13176.6 EDO08038.1 - 1.2e-06 28.1 9.6 1.1 9.4 0.0 7.6 8 0 0 8 8 8 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EDO08038.1 - 1.8e-06 27.9 14.5 0.094 12.7 0.3 6.4 4 1 1 5 5 5 3 Mad3/BUB1 homology region 1 TPR_15 PF13429.6 EDO08038.1 - 2.9e-06 26.7 9.3 0.0051 16.1 1.4 4.9 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EDO08038.1 - 9.5e-06 25.9 13.3 7.2 7.5 0.0 8.7 9 0 0 9 9 9 1 Tetratricopeptide repeat NRDE-2 PF08424.10 EDO08038.1 - 2.1e-05 23.8 15.0 0.28 10.3 0.0 5.4 3 3 2 5 5 5 3 NRDE-2, necessary for RNA interference TPR_9 PF13371.6 EDO08038.1 - 3.1e-05 24.0 3.8 0.55 10.4 0.2 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat U3_assoc_6 PF08640.11 EDO08038.1 - 6e-05 23.0 18.1 0.038 14.1 0.5 6.7 5 2 2 7 7 7 2 U3 small nucleolar RNA-associated protein 6 Fis1_TPR_C PF14853.6 EDO08038.1 - 6.2e-05 23.0 0.1 2.5 8.2 0.0 5.5 7 0 0 7 7 6 1 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 EDO08038.1 - 0.0031 17.7 3.8 0.51 10.6 0.3 3.7 3 1 2 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.14 EDO08038.1 - 0.21 12.3 9.9 1.5 9.6 0.0 5.4 7 0 0 7 7 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 EDO08038.1 - 0.32 10.9 18.1 28 4.8 0.0 8.0 10 0 0 10 10 8 0 Tetratricopeptide repeat DAGK_acc PF00609.19 EDO08039.1 - 2.6e-37 128.6 0.0 3.8e-37 128.1 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain TMEM43 PF07787.12 EDO08039.1 - 5.5e-27 94.7 0.0 9.1e-27 94.0 0.0 1.4 1 0 0 1 1 1 1 Transmembrane protein 43 DAGK_cat PF00781.24 EDO08039.1 - 4.1e-13 49.1 0.0 4.5e-12 45.7 0.0 2.2 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain EpsG PF14897.6 EDO08039.1 - 0.00024 20.6 2.9 0.00036 19.9 2.9 1.2 1 0 0 1 1 1 1 EpsG family DUF5090 PF17009.5 EDO08039.1 - 2.4 8.1 4.8 3.9 7.4 4.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5090) TFIIF_alpha PF05793.12 EDO08040.1 - 0.14 10.7 3.8 0.18 10.4 3.8 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CENP-Q PF13094.6 EDO08042.1 - 0.0012 19.1 1.6 0.0016 18.7 1.6 1.2 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit Rootletin PF15035.6 EDO08042.1 - 0.012 15.7 2.4 0.017 15.2 2.4 1.2 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DNA_pol_D_N PF18018.1 EDO08043.1 - 2.6e-31 108.4 0.0 4.5e-31 107.7 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain DNA_pol_E_B PF04042.16 EDO08043.1 - 3.2e-26 92.0 0.0 4.2e-25 88.3 0.0 2.1 1 1 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Jiv90 PF14901.6 EDO08044.1 - 3.4 7.9 6.4 14 5.9 0.6 2.9 3 0 0 3 3 3 0 Cleavage inducing molecular chaperone DNA_topoisoIV PF00521.20 EDO08045.1 - 8.4e-129 430.2 0.0 1.4e-128 429.4 0.0 1.4 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 EDO08045.1 - 1e-45 155.1 5.7 1e-45 155.1 5.7 2.6 2 0 0 2 2 2 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 EDO08045.1 - 1.2e-21 76.9 0.8 4.3e-21 75.2 0.8 1.9 1 0 0 1 1 1 1 DNA gyrase B Toprim PF01751.22 EDO08045.1 - 9.5e-08 32.2 0.0 2.8e-07 30.7 0.0 1.8 1 0 0 1 1 1 1 Toprim domain HATPase_c PF02518.26 EDO08045.1 - 2.7e-07 31.1 0.0 1.4e-06 28.8 0.0 2.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TyrRSs_C PF16714.5 EDO08045.1 - 0.015 15.1 0.3 0.083 12.7 0.1 2.1 2 0 0 2 2 2 0 Tyrosyl-tRNA synthetase C-terminal domain ATG16 PF08614.11 EDO08046.1 - 0.00038 20.8 13.1 0.00059 20.1 13.1 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) ZapB PF06005.12 EDO08046.1 - 0.00046 20.6 16.3 0.023 15.1 3.0 3.4 2 1 1 3 3 3 3 Cell division protein ZapB PRKG1_interact PF15898.5 EDO08046.1 - 0.00093 20.1 13.7 0.019 15.9 4.5 2.6 2 0 0 2 2 2 2 cGMP-dependent protein kinase interacting domain Seryl_tRNA_N PF02403.22 EDO08046.1 - 0.0026 17.9 6.4 0.0026 17.9 6.4 2.4 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain YabA PF06156.13 EDO08046.1 - 0.0032 18.1 12.1 0.14 12.8 3.0 2.6 2 0 0 2 2 2 2 Initiation control protein YabA GAS PF13851.6 EDO08046.1 - 0.0051 16.2 6.0 0.0051 16.2 6.0 2.2 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding Phage_GP20 PF06810.11 EDO08046.1 - 0.015 15.1 2.0 0.015 15.1 2.0 3.1 1 1 1 3 3 3 0 Phage minor structural protein GP20 APG6_N PF17675.1 EDO08046.1 - 0.021 15.4 9.0 0.021 15.4 9.0 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF1664 PF07889.12 EDO08046.1 - 0.022 14.8 2.3 0.022 14.8 2.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.9 EDO08046.1 - 0.045 13.8 17.6 2.4 8.2 16.7 2.9 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 UPF0242 PF06785.11 EDO08046.1 - 0.11 12.6 15.5 0.027 14.6 4.5 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF4407 PF14362.6 EDO08046.1 - 0.14 11.5 6.5 0.22 10.9 6.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FlaC_arch PF05377.11 EDO08046.1 - 0.19 12.1 7.3 0.41 11.1 0.4 3.4 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) TPR_MLP1_2 PF07926.12 EDO08046.1 - 0.37 10.8 14.0 0.66 10.0 5.6 2.6 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Laminin_II PF06009.12 EDO08046.1 - 0.53 10.3 9.4 0.61 10.1 3.1 2.4 1 1 1 2 2 2 0 Laminin Domain II DUF3450 PF11932.8 EDO08046.1 - 0.54 9.5 10.1 0.052 12.9 3.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF4164 PF13747.6 EDO08046.1 - 0.6 10.4 10.7 0.13 12.6 4.0 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4164) Baculo_PEP_C PF04513.12 EDO08046.1 - 0.66 10.0 6.4 0.9 9.6 1.7 2.9 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus CENP-H PF05837.12 EDO08046.1 - 0.73 10.3 15.5 0.065 13.6 4.7 2.5 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Occludin_ELL PF07303.13 EDO08046.1 - 0.77 10.5 7.6 0.28 11.9 2.5 2.4 1 1 1 2 2 2 0 Occludin homology domain betaPIX_CC PF16523.5 EDO08046.1 - 0.88 9.4 9.9 0.31 10.9 1.7 2.9 2 2 0 2 2 2 0 betaPIX coiled coil Tup_N PF08581.10 EDO08046.1 - 1.1 9.6 10.1 0.21 11.9 3.2 2.5 2 0 0 2 2 2 0 Tup N-terminal Fungal_TACC PF12709.7 EDO08046.1 - 2 8.9 12.2 12 6.5 1.4 4.2 2 1 3 5 5 5 0 Fungal Transforming acidic coiled-coil (TACC) proteins Prefoldin_2 PF01920.20 EDO08046.1 - 2.2 8.3 14.2 5.4 7.0 1.1 3.6 2 1 1 3 3 3 0 Prefoldin subunit V_ATPase_I PF01496.19 EDO08046.1 - 3.9 5.3 7.2 5.2 4.8 7.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Med4 PF10018.9 EDO08046.1 - 5.9 6.5 11.9 0.2 11.3 4.1 2.1 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF2968 PF11180.8 EDO08046.1 - 6.1 6.4 12.5 0.41 10.3 6.3 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF2968) zf-C4H2 PF10146.9 EDO08046.1 - 6.5 7.0 11.1 21 5.3 1.6 2.3 1 1 1 2 2 2 0 Zinc finger-containing protein JIP_LZII PF16471.5 EDO08046.1 - 6.5 7.0 10.9 4.2 7.6 1.9 3.0 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II Nsp1_C PF05064.13 EDO08046.1 - 6.9 6.5 10.5 1.5 8.6 5.7 2.5 3 1 0 3 3 1 0 Nsp1-like C-terminal region FHA PF00498.26 EDO08047.1 - 5.1e-17 62.0 0.1 1.2e-16 60.9 0.1 1.6 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EDO08047.1 - 1.8e-11 44.2 0.0 3.4e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DUF2745 PF10922.8 EDO08047.1 - 0.0069 16.6 1.1 0.013 15.7 1.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2745) Tubulin PF00091.25 EDO08048.1 - 1.9e-70 237.1 0.0 4.9e-70 235.7 0.0 1.6 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EDO08048.1 - 1.6e-41 141.4 0.2 2.4e-41 140.8 0.2 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EDO08048.1 - 2.9e-05 24.4 0.0 7.2e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 EDO08048.1 - 0.0034 17.1 0.0 0.0072 16.0 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 EDO08048.1 - 0.0042 16.3 0.0 0.0089 15.3 0.0 1.5 1 0 0 1 1 1 1 Tubulin like Rcd1 PF04078.13 EDO08049.1 - 9.7e-103 343.0 0.6 1.2e-102 342.7 0.6 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Pkinase PF00069.25 EDO08050.1 - 1.7e-09 37.5 0.0 3.7e-09 36.3 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Kdo PF06293.14 EDO08050.1 - 0.2 11.0 0.0 0.32 10.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4872 PF16169.5 EDO08051.1 - 0.021 14.6 3.4 1.2 8.9 0.0 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4872) DUF2543 PF10820.8 EDO08051.1 - 0.24 11.6 1.7 0.54 10.5 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2543) ALMT PF11744.8 EDO08051.1 - 0.53 9.0 12.4 4 6.2 8.8 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter ArAE_1_C PF11728.8 EDO08051.1 - 5.2 7.0 11.1 1.3 9.0 3.2 3.3 3 1 0 3 3 3 0 Putative aromatic acid exporter C-terminal domain ABC_tran PF00005.27 EDO08053.1 - 3.1e-37 128.1 0.0 6.6e-37 127.1 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EDO08053.1 - 4.4e-18 65.9 10.7 6.3e-18 65.4 10.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 EDO08053.1 - 1.7e-08 34.2 0.0 1.5e-05 24.5 0.0 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EDO08053.1 - 0.00016 21.9 0.0 0.0041 17.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EDO08053.1 - 0.00035 21.0 0.0 0.0012 19.3 0.0 1.8 2 0 0 2 2 1 1 AAA ATPase domain ABC_membrane_2 PF06472.15 EDO08053.1 - 0.00072 19.0 2.1 0.0013 18.2 2.1 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 RsgA_GTPase PF03193.16 EDO08053.1 - 0.00092 19.2 0.1 0.014 15.3 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 EDO08053.1 - 0.0012 18.5 0.0 0.0031 17.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_7 PF12775.7 EDO08053.1 - 0.0028 17.2 0.0 0.0086 15.6 0.0 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region APS_kinase PF01583.20 EDO08053.1 - 0.0057 16.6 0.8 0.027 14.3 0.0 2.3 2 0 0 2 2 2 1 Adenylylsulphate kinase Gtr1_RagA PF04670.12 EDO08053.1 - 0.0096 15.3 0.4 0.08 12.3 0.0 2.3 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region TniB PF05621.11 EDO08053.1 - 0.013 14.9 0.0 0.4 10.1 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein Sigma54_activat PF00158.26 EDO08053.1 - 0.014 15.1 0.0 0.026 14.2 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 EDO08053.1 - 0.014 14.6 0.0 0.03 13.6 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin DUF87 PF01935.17 EDO08053.1 - 0.015 15.4 0.1 0.044 13.9 0.0 1.8 2 0 0 2 2 1 0 Helicase HerA, central domain AAA_15 PF13175.6 EDO08053.1 - 0.019 14.7 0.1 0.03 14.1 0.1 1.3 1 0 0 1 1 1 0 AAA ATPase domain ATP-synt_ab PF00006.25 EDO08053.1 - 0.021 14.5 0.1 0.034 13.8 0.1 1.4 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain G-alpha PF00503.20 EDO08053.1 - 0.025 13.7 0.0 0.035 13.3 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit AAA_24 PF13479.6 EDO08053.1 - 0.026 14.2 0.1 0.045 13.5 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EDO08053.1 - 0.029 14.9 0.1 0.065 13.7 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EDO08053.1 - 0.03 14.7 0.0 0.21 12.0 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.6 EDO08053.1 - 0.045 13.5 0.0 0.88 9.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EDO08053.1 - 0.054 13.7 0.3 1.3 9.3 0.3 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_10 PF12846.7 EDO08053.1 - 0.057 12.3 0.0 0.11 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain AAA_18 PF13238.6 EDO08053.1 - 0.066 13.8 0.0 0.25 11.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 EDO08053.1 - 0.09 11.9 0.0 0.2 10.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DEAD PF00270.29 EDO08053.1 - 0.092 12.5 0.2 0.62 9.8 0.2 2.0 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_5 PF07728.14 EDO08053.1 - 0.095 12.7 0.0 2.1 8.3 0.0 2.8 2 1 0 3 3 3 0 AAA domain (dynein-related subfamily) NB-ARC PF00931.22 EDO08053.1 - 0.1 11.8 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_30 PF13604.6 EDO08053.1 - 0.1 12.3 0.0 0.32 10.7 0.0 2.0 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 EDO08053.1 - 0.14 12.1 0.0 0.39 10.6 0.0 1.7 1 0 0 1 1 1 0 NACHT domain UCH_1 PF13423.6 EDO08054.1 - 1.4e-12 47.9 2.7 4.9e-12 46.1 2.9 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase LcrV PF04792.12 EDO08054.1 - 0.056 12.7 0.2 5.5 6.2 0.0 3.0 3 0 0 3 3 3 0 V antigen (LcrV) protein RNase_T PF00929.24 EDO08055.1 - 4.6e-15 56.6 0.0 9.3e-15 55.6 0.0 1.5 2 0 0 2 2 2 1 Exonuclease Ubiq_cyt_C_chap PF03981.12 EDO08059.1 - 2.8e-24 85.8 0.1 4.1e-24 85.3 0.1 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone GTP1_OBG PF01018.22 EDO08060.1 - 8.5e-25 87.2 0.2 1.2e-24 86.6 0.2 1.2 1 0 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.23 EDO08060.1 - 3e-12 46.6 0.0 4.9e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDO08060.1 - 1.8e-08 34.1 0.0 3.2e-08 33.2 0.0 1.4 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EDO08060.1 - 3.3e-05 23.5 0.0 0.097 12.2 0.0 2.2 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EDO08060.1 - 0.0015 17.9 0.0 0.0021 17.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1_Xtn PF16897.5 EDO08060.1 - 0.0041 17.1 0.1 0.0073 16.3 0.1 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain Roc PF08477.13 EDO08060.1 - 0.0076 16.5 0.0 0.21 11.8 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EDO08060.1 - 0.024 14.6 0.1 5.7 6.8 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase Ras PF00071.22 EDO08060.1 - 0.062 12.9 0.0 12 5.5 0.0 2.1 2 0 0 2 2 2 0 Ras family SRPRB PF09439.10 EDO08060.1 - 0.16 11.4 0.0 0.26 10.7 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Tubulin PF00091.25 EDO08061.1 - 1.4e-26 93.9 0.1 4.1e-25 89.1 0.0 2.3 1 1 1 2 2 2 2 Tubulin/FtsZ family, GTPase domain Dcc1 PF09724.9 EDO08062.1 - 0.0043 16.4 1.9 5.6 6.2 0.0 3.3 2 1 0 2 2 2 2 Sister chromatid cohesion protein Dcc1 ANAPC4_WD40 PF12894.7 EDO08063.1 - 5.5e-09 36.2 2.6 0.021 15.1 0.2 4.4 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO08063.1 - 1.9e-05 25.3 11.3 1.5 9.9 0.1 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat RAB3GAP2_N PF14655.6 EDO08063.1 - 0.00016 21.1 0.3 0.00066 19.1 0.0 2.0 2 1 1 3 3 3 1 Rab3 GTPase-activating protein regulatory subunit N-terminus CDT1 PF08839.11 EDO08064.1 - 1.1e-12 48.7 0.0 2.2e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 DNA replication factor CDT1 like Proho_convert PF12177.8 EDO08065.1 - 0.082 12.9 0.5 0.18 11.8 0.5 1.5 1 0 0 1 1 1 0 Prohormone convertase enzyme DUF745 PF05335.13 EDO08065.1 - 7.2 6.3 69.1 0.032 14.0 22.0 4.1 1 1 3 4 4 4 0 Protein of unknown function (DUF745) PDE4_UCR PF18100.1 EDO08066.1 - 0.066 13.9 1.1 0.67 10.6 0.0 3.0 2 2 1 3 3 3 0 Phosphodiesterase 4 upstream conserved regions (UCR) Com_YlbF PF06133.11 EDO08066.1 - 7.7 7.2 13.5 0.93 10.1 1.1 3.4 3 0 0 3 3 3 0 Control of competence regulator ComK, YlbF/YmcA CDT1 PF08839.11 EDO08067.1 - 1.1e-12 48.7 0.0 2.2e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 DNA replication factor CDT1 like LisH PF08513.11 EDO08068.1 - 1e-10 41.1 0.2 2.5e-10 39.9 0.2 1.7 1 0 0 1 1 1 1 LisH ANAPC4_WD40 PF12894.7 EDO08068.1 - 8.4e-09 35.6 2.4 0.027 14.8 0.1 4.4 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDO08068.1 - 2.2e-05 24.4 2.2 0.0047 16.8 0.2 2.7 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 EDO08068.1 - 3.9e-05 24.3 11.2 1.7 9.6 0.1 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat RAB3GAP2_N PF14655.6 EDO08068.1 - 0.0002 20.7 0.2 0.00074 18.9 0.0 1.9 2 1 1 3 3 3 1 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF3223 PF11523.8 EDO08069.1 - 3.3e-15 56.7 0.1 9e-15 55.3 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3223) La PF05383.17 EDO08069.1 - 7.6e-11 41.9 0.1 1.7e-10 40.8 0.1 1.6 1 0 0 1 1 1 1 La domain Reoviridae_Vp9 PF08978.10 EDO08070.1 - 0.11 11.6 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Reoviridae VP9 DUF3767 PF12597.8 EDO08070.1 - 0.2 11.5 0.0 0.38 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3767) DHHC PF01529.20 EDO08071.1 - 7.9e-32 110.2 15.5 7.9e-32 110.2 15.5 2.2 2 0 0 2 2 2 2 DHHC palmitoyltransferase ATP-synt_F PF01990.17 EDO08072.1 - 6.6e-30 103.3 0.8 7.9e-30 103.0 0.8 1.1 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit Imm8 PF15586.6 EDO08072.1 - 0.081 13.0 0.1 0.12 12.5 0.1 1.2 1 0 0 1 1 1 0 Immunity protein 8 eIF-5_eIF-2B PF01873.17 EDO08072.1 - 0.088 12.7 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 Domain found in IF2B/IF5 Diphthami_syn_2 PF01902.17 EDO08073.1 - 1.3e-44 152.3 0.2 3.1e-44 151.1 0.2 1.5 1 1 0 1 1 1 1 Diphthamide synthase QueC PF06508.13 EDO08073.1 - 2.7e-05 23.8 0.0 3.6e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 EDO08073.1 - 0.0025 16.7 0.0 0.0041 16.0 0.0 1.3 1 0 0 1 1 1 1 tRNA methyl transferase Asparaginase_C PF17763.1 EDO08073.1 - 0.14 12.4 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 Glutaminase/Asparaginase C-terminal domain Rep_fac-A_C PF08646.10 EDO08074.1 - 2.8e-25 88.8 1.4 2.8e-25 88.8 1.4 2.4 1 1 1 2 2 2 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 EDO08074.1 - 1.5e-16 60.1 0.3 2.1e-12 46.8 0.0 2.5 2 0 0 2 2 2 2 Replication protein A OB domain tRNA_anti-codon PF01336.25 EDO08074.1 - 3.9e-07 29.9 0.2 1.1e-05 25.3 0.0 3.2 4 0 0 4 4 4 1 OB-fold nucleic acid binding domain RecJ_OB PF17768.1 EDO08074.1 - 0.0046 17.2 0.1 1.7 8.9 0.0 3.2 3 0 0 3 3 3 1 RecJ OB domain SSB PF00436.25 EDO08074.1 - 0.0065 16.5 2.2 0.55 10.3 0.0 3.4 3 1 1 4 4 4 1 Single-strand binding protein family DUF223 PF02721.14 EDO08074.1 - 0.017 15.4 0.4 0.057 13.7 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF223 DUF4941 PF16299.5 EDO08074.1 - 0.083 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4941) Lar_restr_allev PF14354.6 EDO08074.1 - 0.12 12.8 1.1 0.39 11.1 1.1 1.9 1 0 0 1 1 1 0 Restriction alleviation protein Lar DUF406 PF04175.12 EDO08074.1 - 0.23 11.9 3.0 0.34 11.4 1.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF406) Brix PF04427.18 EDO08076.1 - 4.3e-36 124.8 0.0 6.1e-36 124.3 0.0 1.2 1 0 0 1 1 1 1 Brix domain PNP_UDP_1 PF01048.20 EDO08077.1 - 9.5e-21 74.1 0.0 1.1e-20 73.9 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily PNP_UDP_1 PF01048.20 EDO08078.1 - 3.3e-09 36.3 0.0 3.8e-09 36.1 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily Mito_carr PF00153.27 EDO08079.1 - 8.8e-53 176.2 1.4 1.9e-18 66.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein eIF2A PF08662.11 EDO08080.1 - 1.5e-53 181.6 0.2 7.5e-52 176.0 0.0 2.2 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A tRNA-synt_His PF13393.6 EDO08081.1 - 9.1e-26 90.8 0.0 2.2e-25 89.6 0.0 1.5 1 0 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.25 EDO08081.1 - 0.006 16.6 0.0 0.011 15.7 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) DUF903 PF06004.12 EDO08081.1 - 0.15 12.0 0.1 25 4.9 0.0 3.0 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF903) ThiF PF00899.21 EDO08083.1 - 2.9e-46 157.8 0.6 4.3e-46 157.2 0.6 1.2 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 EDO08083.1 - 0.012 15.9 6.8 0.13 12.5 4.2 2.8 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 EDO08083.1 - 0.016 15.6 0.1 0.041 14.3 0.1 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding PglD_N PF17836.1 EDO08083.1 - 0.02 15.5 0.1 0.047 14.3 0.1 1.7 1 0 0 1 1 1 0 PglD N-terminal domain UDPG_MGDP_dh_N PF03721.14 EDO08083.1 - 0.044 13.4 0.3 0.073 12.6 0.3 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 EDO08083.1 - 0.046 13.1 0.4 0.1 11.9 0.4 1.5 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 EDO08083.1 - 0.055 12.7 1.2 0.094 11.9 1.2 1.3 1 0 0 1 1 1 0 FAD binding domain TrkA_N PF02254.18 EDO08083.1 - 0.089 13.1 0.1 0.25 11.6 0.1 1.8 1 0 0 1 1 1 0 TrkA-N domain DEAD PF00270.29 EDO08085.1 - 1.4e-37 129.2 0.1 2.3e-37 128.5 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO08085.1 - 2.5e-20 72.9 0.0 4.4e-18 65.6 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EDO08085.1 - 4.7e-15 55.5 0.1 9.6e-15 54.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EDO08085.1 - 0.064 13.3 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Arteri_nucleo PF01481.16 EDO08085.1 - 0.096 13.0 0.0 0.7 10.2 0.0 2.4 2 0 0 2 2 2 0 Arterivirus nucleocapsid protein DUF3658 PF12395.8 EDO08085.1 - 0.17 11.8 2.5 0.4 10.6 2.5 1.6 1 0 0 1 1 1 0 Protein of unknown function Peptidase_M41 PF01434.18 EDO08086.1 - 2.1e-58 197.4 0.0 3.3e-58 196.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EDO08086.1 - 8.5e-41 139.5 0.0 1.5e-40 138.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO08086.1 - 2.1e-09 37.1 0.2 4.6e-09 35.9 0.2 1.6 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 EDO08086.1 - 8.5e-07 29.3 0.0 2.9e-06 27.6 0.0 1.9 1 0 0 1 1 1 1 FtsH Extracellular AAA_22 PF13401.6 EDO08086.1 - 0.00033 20.9 0.1 0.047 14.0 0.1 2.5 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.13 EDO08086.1 - 0.0023 17.2 0.0 0.004 16.4 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_5 PF07728.14 EDO08086.1 - 0.0049 16.9 0.0 0.016 15.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EDO08086.1 - 0.0092 15.7 0.0 0.021 14.5 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_17 PF13207.6 EDO08086.1 - 0.028 14.9 0.0 0.066 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EDO08086.1 - 0.051 13.7 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EDO08086.1 - 0.056 13.8 0.1 0.63 10.4 0.1 2.3 1 1 0 2 2 2 0 AAA ATPase domain AAA_2 PF07724.14 EDO08086.1 - 0.057 13.5 0.0 0.18 11.9 0.0 1.8 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 EDO08086.1 - 0.092 12.5 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 EDO08086.1 - 0.095 12.1 0.3 0.43 9.9 0.2 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Peptidase_M50B PF13398.6 EDO08086.1 - 0.17 11.5 0.0 0.34 10.5 0.0 1.4 1 0 0 1 1 1 0 Peptidase M50B-like SUI1 PF01253.22 EDO08087.1 - 1.4e-18 67.2 0.2 2.1e-18 66.6 0.2 1.3 1 0 0 1 1 1 1 Translation initiation factor SUI1 NMD3 PF04981.13 EDO08087.1 - 0.03 13.8 0.0 0.043 13.3 0.0 1.2 1 0 0 1 1 1 0 NMD3 family Podoplanin PF05808.11 EDO08090.1 - 4.4 7.4 6.5 18 5.4 6.6 2.1 1 1 0 1 1 1 0 Podoplanin SRP54 PF00448.22 EDO08091.1 - 4e-54 183.3 0.2 1.8e-53 181.1 0.2 2.0 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.13 EDO08091.1 - 2.7e-13 50.5 9.7 9.9e-10 38.8 0.2 2.2 1 1 1 2 2 2 2 Signal recognition particle, alpha subunit, N-terminal SRP54_N PF02881.19 EDO08091.1 - 1.7e-05 24.9 1.2 8e-05 22.8 0.2 2.7 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 EDO08091.1 - 2.3e-05 23.5 0.0 0.00012 21.2 0.0 2.1 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CbiA PF01656.23 EDO08091.1 - 0.00013 22.0 0.1 0.00041 20.4 0.1 1.9 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_30 PF13604.6 EDO08091.1 - 0.00044 20.0 0.0 0.00088 19.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 EDO08091.1 - 0.0022 17.9 0.1 0.12 12.2 0.1 3.0 2 1 1 3 3 3 1 NTPase AAA_16 PF13191.6 EDO08091.1 - 0.0026 18.2 0.0 0.0069 16.8 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_31 PF13614.6 EDO08091.1 - 0.0054 16.7 0.1 0.18 11.7 0.1 2.6 1 1 1 2 2 2 1 AAA domain Fer4_NifH PF00142.18 EDO08091.1 - 0.028 13.9 0.1 0.051 13.0 0.1 1.4 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_29 PF13555.6 EDO08091.1 - 0.033 13.9 0.0 0.23 11.2 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_22 PF13401.6 EDO08091.1 - 0.036 14.3 0.0 0.14 12.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 EDO08091.1 - 0.051 13.5 0.4 0.79 9.6 0.0 2.7 3 0 0 3 3 3 0 Adenylylsulphate kinase AAA_17 PF13207.6 EDO08091.1 - 0.092 13.2 0.0 2 8.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EDO08091.1 - 0.1 13.1 0.5 1.3 9.6 0.0 2.5 2 0 0 2 2 2 0 ABC transporter NDK PF00334.19 EDO08092.1 - 1.2e-49 167.7 0.0 1.4e-49 167.6 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase DUF501 PF04417.12 EDO08093.1 - 9.1e-14 51.5 0.0 1.1e-06 28.5 0.0 2.8 2 1 0 2 2 2 2 Protein of unknown function (DUF501) Lipoprotein_10 PF03202.13 EDO08093.1 - 0.075 13.5 0.0 0.31 11.5 0.0 2.0 1 0 0 1 1 1 0 Putative mycoplasma lipoprotein, C-terminal region zf-Tim10_DDP PF02953.15 EDO08094.1 - 0.032 13.9 0.0 0.16 11.6 0.0 2.2 1 0 0 1 1 1 0 Tim10/DDP family zinc finger ECD PF18432.1 EDO08094.1 - 0.082 12.9 0.4 0.37 10.8 0.1 2.3 2 0 0 2 2 2 0 Extracellular Cadherin domain Clat_adaptor_s PF01217.20 EDO08095.1 - 5.2e-35 120.5 1.2 5.6e-35 120.4 1.2 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DnaJ PF00226.31 EDO08097.1 - 2.5e-10 40.3 1.5 6e-10 39.1 0.0 2.4 2 0 0 2 2 2 1 DnaJ domain TPR_1 PF00515.28 EDO08097.1 - 0.0047 16.7 0.5 0.047 13.5 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat PI_PP_I PF18363.1 EDO08097.1 - 0.042 14.0 2.7 23 5.3 0.0 4.1 3 1 2 5 5 5 0 Phosphoinositide phosphatase insertion domain DUF3450 PF11932.8 EDO08097.1 - 1.9 7.7 7.7 0.3 10.3 3.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF1640 PF07798.11 EDO08097.1 - 6.3 6.8 10.5 6.2 6.8 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) CTNNBL PF08216.11 EDO08098.1 - 3e-22 78.8 0.0 8.2e-22 77.3 0.0 1.8 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear TFCD_C PF12612.8 EDO08098.1 - 0.0014 18.5 0.2 0.035 13.9 0.0 2.9 3 1 0 3 3 3 1 Tubulin folding cofactor D C terminal ParcG PF10274.9 EDO08098.1 - 0.052 13.7 0.4 0.29 11.2 0.3 2.1 1 1 1 2 2 2 0 Parkin co-regulated protein CAS_CSE1 PF03378.15 EDO08098.1 - 0.066 11.7 0.0 0.25 9.8 0.0 1.9 2 0 0 2 2 2 0 CAS/CSE protein, C-terminus KIF1B PF12423.8 EDO08098.1 - 0.3 11.6 1.3 0.52 10.8 0.3 1.9 2 0 0 2 2 2 0 Kinesin protein 1B Carb_anhydrase PF00194.21 EDO08099.1 - 1.3e-18 67.5 2.6 8.8e-14 51.6 0.1 3.4 2 1 0 2 2 2 2 Eukaryotic-type carbonic anhydrase DUF1911 PF08929.10 EDO08099.1 - 0.089 13.6 0.0 0.28 12.0 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1911) WD40 PF00400.32 EDO08101.1 - 1.7e-26 92.0 10.8 4.8e-06 27.2 1.3 5.7 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO08101.1 - 0.0003 21.0 0.0 0.64 10.3 0.0 3.7 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EDO08101.1 - 0.0026 17.4 0.1 0.078 12.5 0.1 2.9 1 1 1 2 2 2 1 PQQ-like domain eIF2A PF08662.11 EDO08101.1 - 0.015 15.1 0.0 3.3 7.5 0.0 3.0 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A DarA_C PF18789.1 EDO08101.1 - 0.076 13.3 0.4 0.32 11.3 0.1 2.2 2 0 0 2 2 2 0 Defence against restriction A C-terminal Ribo_biogen_C PF04034.13 EDO08102.1 - 6.8e-44 148.6 0.0 9.6e-44 148.2 0.0 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 EDO08102.1 - 2.3e-13 49.7 0.2 3.8e-13 49.0 0.2 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI CwfJ_C_2 PF04676.14 EDO08103.1 - 3.9e-17 62.9 0.0 7.9e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 CwfJ_C_1 PF04677.15 EDO08103.1 - 7.3e-17 61.4 0.1 1.4e-16 60.5 0.1 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 RCC1 PF00415.18 EDO08104.1 - 7.5e-14 52.1 8.7 7.9e-10 39.2 2.5 4.8 6 0 0 6 6 6 2 Regulator of chromosome condensation (RCC1) repeat IQ PF00612.27 EDO08104.1 - 5.4e-12 44.4 40.1 3.1e-05 23.4 1.7 6.9 7 0 0 7 7 7 4 IQ calmodulin-binding motif RCC1_2 PF13540.6 EDO08104.1 - 8.2e-10 38.2 1.3 7.2e-08 32.0 0.1 3.9 4 0 0 4 4 4 1 Regulator of chromosome condensation (RCC1) repeat Aha1_N PF09229.11 EDO08105.1 - 3e-24 85.8 1.4 4.9e-24 85.1 0.1 2.1 2 0 0 2 2 2 1 Activator of Hsp90 ATPase, N-terminal TPR_2 PF07719.17 EDO08105.1 - 1.2e-06 28.2 6.9 0.64 10.3 0.5 4.0 4 0 0 4 4 3 3 Tetratricopeptide repeat DUF3856 PF12968.7 EDO08105.1 - 1.1e-05 25.6 0.4 3.4e-05 23.9 0.0 2.0 2 0 0 2 2 2 1 Domain of Unknown Function (DUF3856) TPR_19 PF14559.6 EDO08105.1 - 0.00025 21.5 2.0 0.0024 18.3 1.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EDO08105.1 - 0.0011 18.7 10.4 0.35 10.8 0.3 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 EDO08105.1 - 0.0015 19.1 2.6 0.13 13.0 0.5 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDO08105.1 - 0.0031 18.2 0.6 0.029 15.2 0.5 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EDO08105.1 - 0.0048 16.9 0.9 0.059 13.5 0.3 2.7 1 1 1 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 EDO08105.1 - 0.012 15.8 0.3 0.024 14.8 0.3 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 EDO08105.1 - 0.028 14.6 3.0 11 6.5 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EDO08105.1 - 0.066 13.7 1.5 1.9 8.9 0.7 2.4 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation Amidinotransf PF02274.17 EDO08105.1 - 0.092 11.8 4.6 0.074 12.1 1.4 2.0 2 0 0 2 2 2 0 Amidinotransferase TPR_11 PF13414.6 EDO08105.1 - 0.49 10.1 3.3 4.9 6.9 0.1 3.1 2 1 1 3 3 3 0 TPR repeat Myb_DNA-binding PF00249.31 EDO08106.1 - 2.7e-07 30.7 0.1 6e-07 29.6 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDO08106.1 - 0.0015 18.7 0.1 0.0054 17.0 0.0 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EDO08106.1 - 0.041 14.3 0.1 0.33 11.4 0.1 2.3 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.6 EDO08106.1 - 0.082 13.0 0.0 1.1 9.3 0.0 2.2 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain AAA_16 PF13191.6 EDO08107.1 - 7.9e-08 32.9 0.1 2.9e-07 31.0 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain ATPase_2 PF01637.18 EDO08107.1 - 1.7e-07 31.4 0.1 2.6e-07 30.8 0.1 1.2 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea NACHT PF05729.12 EDO08107.1 - 2.8e-06 27.4 0.0 2.2e-05 24.5 0.0 2.4 2 1 0 2 2 2 1 NACHT domain AAA_19 PF13245.6 EDO08107.1 - 5.2e-06 26.9 0.1 0.00038 20.8 0.0 2.8 3 1 0 3 3 2 1 AAA domain AAA_22 PF13401.6 EDO08107.1 - 6.5e-05 23.2 0.1 0.00013 22.2 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDO08107.1 - 0.00035 20.8 0.5 0.0088 16.2 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA PF00004.29 EDO08107.1 - 0.0004 20.8 0.1 0.0015 19.0 0.1 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 EDO08107.1 - 0.00046 19.5 0.0 0.00083 18.7 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) NB-ARC PF00931.22 EDO08107.1 - 0.00062 19.0 0.0 0.0011 18.2 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain NTPase_1 PF03266.15 EDO08107.1 - 0.0018 18.2 0.2 0.0039 17.1 0.2 1.8 1 1 0 1 1 1 1 NTPase T2SSE PF00437.20 EDO08107.1 - 0.0039 16.3 0.0 0.0093 15.1 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein Viral_helicase1 PF01443.18 EDO08107.1 - 0.005 16.6 0.0 0.011 15.5 0.0 1.6 1 1 0 1 1 1 1 Viral (Superfamily 1) RNA helicase Zeta_toxin PF06414.12 EDO08107.1 - 0.0052 16.1 0.0 0.0089 15.3 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin Microtub_bd PF16796.5 EDO08107.1 - 0.0086 16.0 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding RNA12 PF10443.9 EDO08107.1 - 0.017 13.9 0.0 0.029 13.1 0.0 1.3 1 0 0 1 1 1 0 RNA12 protein DnaB_C PF03796.15 EDO08107.1 - 0.017 14.4 0.0 0.032 13.6 0.0 1.4 1 1 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_11 PF13086.6 EDO08107.1 - 0.018 14.8 0.0 0.027 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EDO08107.1 - 0.021 15.4 0.1 0.061 13.9 0.1 2.0 1 1 0 1 1 1 0 AAA domain PIF1 PF05970.14 EDO08107.1 - 0.027 13.6 0.0 0.043 13.0 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase KTI12 PF08433.10 EDO08107.1 - 0.029 13.8 0.0 0.062 12.7 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 ResIII PF04851.15 EDO08107.1 - 0.047 13.7 0.0 0.095 12.7 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit TniB PF05621.11 EDO08107.1 - 0.048 13.1 0.4 0.18 11.2 0.4 2.1 1 1 0 1 1 1 0 Bacterial TniB protein AAA_30 PF13604.6 EDO08107.1 - 0.061 13.0 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.9 EDO08107.1 - 0.071 12.3 0.1 0.12 11.5 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_7 PF12775.7 EDO08107.1 - 0.075 12.5 0.1 0.23 11.0 0.1 1.8 1 1 1 2 2 2 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 EDO08107.1 - 0.077 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein UvrD-helicase PF00580.21 EDO08107.1 - 0.079 12.5 0.2 0.17 11.4 0.1 1.7 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain KAP_NTPase PF07693.14 EDO08107.1 - 0.087 12.0 0.2 0.34 10.1 0.0 1.7 1 1 0 2 2 2 0 KAP family P-loop domain cobW PF02492.19 EDO08107.1 - 0.092 12.3 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 EDO08107.1 - 0.095 12.3 0.1 0.27 10.8 0.0 1.9 1 1 1 2 2 2 0 AAA domain MobB PF03205.14 EDO08107.1 - 0.12 12.3 0.0 0.3 11.0 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B PhoH PF02562.16 EDO08107.1 - 0.14 11.6 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein RNA_helicase PF00910.22 EDO08107.1 - 0.15 12.4 0.0 0.34 11.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Oxysterol_BP PF01237.18 EDO08108.1 - 3.1e-125 417.9 0.0 4.3e-125 417.4 0.0 1.2 1 0 0 1 1 1 1 Oxysterol-binding protein Pkinase PF00069.25 EDO08110.1 - 3.2e-78 262.7 0.1 4.8e-78 262.2 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO08110.1 - 3.6e-37 128.0 0.1 5.6e-37 127.4 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.6 EDO08110.1 - 6.1e-19 68.2 0.3 1e-11 45.1 0.8 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EDO08110.1 - 8.4e-18 62.5 1.7 6.3e-06 25.4 0.2 3.7 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EDO08110.1 - 1.8e-12 46.9 2.4 1.1e-05 25.2 1.2 3.7 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EDO08110.1 - 7e-12 44.3 5.8 0.0049 16.7 0.0 4.9 5 0 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 EDO08110.1 - 5.7e-09 35.1 5.6 0.053 13.0 0.1 4.1 4 0 0 4 4 4 3 EF hand APH PF01636.23 EDO08110.1 - 9.4e-05 22.4 0.0 0.0012 18.8 0.0 2.3 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EDO08110.1 - 0.0046 16.3 0.0 0.0079 15.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EDO08110.1 - 0.022 13.6 0.0 0.058 12.2 0.0 1.6 1 0 0 1 1 1 0 Fungal protein kinase YrbL-PhoP_reg PF10707.9 EDO08110.1 - 0.046 13.2 0.1 0.29 10.6 0.0 2.1 1 1 1 2 2 2 0 PhoP regulatory network protein YrbL Choline_kinase PF01633.20 EDO08110.1 - 0.078 12.5 0.1 0.24 10.9 0.0 1.9 2 0 0 2 2 2 0 Choline/ethanolamine kinase YdjO PF14169.6 EDO08110.1 - 5.2 6.9 8.6 2 8.2 3.5 2.4 2 0 0 2 2 2 0 Cold-inducible protein YdjO UBA_4 PF14555.6 EDO08111.1 - 0.0046 16.7 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain UBA PF00627.31 EDO08111.1 - 0.01 15.7 0.2 0.037 14.0 0.1 2.0 2 0 0 2 2 2 0 UBA/TS-N domain UBA_5 PF16577.5 EDO08111.1 - 0.13 12.4 0.2 0.38 10.9 0.0 1.8 2 0 0 2 2 2 0 UBA domain PseudoU_synth_1 PF01416.20 EDO08112.1 - 6.9e-22 78.0 0.0 1.9e-20 73.3 0.0 2.5 2 1 0 2 2 2 1 tRNA pseudouridine synthase DUF2344 PF10105.9 EDO08112.1 - 0.0044 16.9 0.0 0.0059 16.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2344) Glyco_hydro_35 PF01301.19 EDO08114.1 - 0.026 14.2 0.2 0.037 13.7 0.2 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 35 DUF3316 PF11777.8 EDO08114.1 - 0.077 13.1 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3316) GNAT_acetyltran PF12746.7 EDO08114.1 - 0.24 11.0 1.5 0.24 11.0 0.3 1.6 2 0 0 2 2 2 0 GNAT acetyltransferase Cytochrom_C PF00034.21 EDO08115.1 - 3.5e-15 56.9 0.1 4.5e-15 56.6 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 EDO08115.1 - 1.5e-06 28.4 2.7 4.9e-06 26.8 2.7 1.8 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 EDO08115.1 - 7.1e-05 22.5 0.1 0.00016 21.4 0.1 1.5 1 0 0 1 1 1 1 Cytochrome c-550 domain Haem_bd PF14376.6 EDO08115.1 - 0.15 12.0 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Haem-binding domain Sec62 PF03839.16 EDO08118.1 - 1.8e-26 93.0 8.3 3.1e-26 92.2 8.3 1.3 1 0 0 1 1 1 1 Translocation protein Sec62 MgtE PF01769.16 EDO08118.1 - 0.15 12.5 3.7 0.3 11.5 3.7 1.4 1 0 0 1 1 1 0 Divalent cation transporter Astro_capsid_p PF12226.8 EDO08118.1 - 0.35 10.0 0.0 0.35 10.0 0.0 1.5 2 0 0 2 2 2 0 Turkey astrovirus capsid protein Ribosomal_L20 PF00453.18 EDO08119.1 - 8e-23 80.6 0.7 1e-22 80.2 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L20 HTH_1 PF00126.27 EDO08119.1 - 0.0056 16.6 0.2 0.027 14.4 0.0 2.0 2 1 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family ABC_tran PF00005.27 EDO08120.1 - 4.2e-32 111.5 0.0 5.9e-15 56.0 0.0 2.7 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EDO08120.1 - 3.5e-09 36.9 2.3 0.0015 18.4 0.1 4.1 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EDO08120.1 - 9.6e-07 28.8 0.2 0.0037 17.2 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EDO08120.1 - 2.9e-06 27.8 0.0 0.092 13.1 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 EDO08120.1 - 1.1e-05 26.1 2.0 0.13 12.7 0.2 2.3 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EDO08120.1 - 1.6e-05 24.7 0.1 0.028 14.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EDO08120.1 - 3.5e-05 23.5 0.3 0.12 12.1 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EDO08120.1 - 5.2e-05 23.3 0.1 0.062 13.4 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase SbcCD_C PF13558.6 EDO08120.1 - 7.2e-05 23.0 0.0 0.00035 20.8 0.0 2.1 2 0 0 2 2 1 1 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.6 EDO08120.1 - 0.00011 22.5 0.2 0.48 10.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 EDO08120.1 - 0.00013 21.3 0.1 0.11 11.7 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin NB-ARC PF00931.22 EDO08120.1 - 0.00037 19.8 0.3 0.088 12.0 0.0 2.6 2 0 0 2 2 2 1 NB-ARC domain NACHT PF05729.12 EDO08120.1 - 0.00069 19.6 0.5 1.2 9.1 0.1 2.5 2 0 0 2 2 2 2 NACHT domain AAA_18 PF13238.6 EDO08120.1 - 0.0018 18.8 0.0 1.6 9.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 EDO08120.1 - 0.0024 16.9 0.5 0.074 12.0 0.2 2.2 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB ATPase_2 PF01637.18 EDO08120.1 - 0.0028 17.6 0.2 0.26 11.2 0.0 2.6 3 0 0 3 3 2 1 ATPase domain predominantly from Archaea AAA_7 PF12775.7 EDO08120.1 - 0.0048 16.4 0.2 0.8 9.2 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region TsaE PF02367.17 EDO08120.1 - 0.015 15.3 0.4 1.1 9.3 0.1 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE cobW PF02492.19 EDO08120.1 - 0.034 13.7 0.5 1.2 8.8 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 EDO08120.1 - 0.035 14.5 0.1 1.7 9.0 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) SMC_N PF02463.19 EDO08120.1 - 0.036 13.5 0.5 0.87 9.0 0.1 2.5 3 0 0 3 3 2 0 RecF/RecN/SMC N terminal domain AAA_28 PF13521.6 EDO08120.1 - 0.042 14.1 2.5 20 5.4 0.1 3.7 4 0 0 4 4 3 0 AAA domain PduV-EutP PF10662.9 EDO08120.1 - 0.05 13.3 2.7 3.8 7.3 0.0 2.8 3 0 0 3 3 2 0 Ethanolamine utilisation - propanediol utilisation IstB_IS21 PF01695.17 EDO08120.1 - 0.06 13.1 0.1 1.2 8.9 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein Dynamin_N PF00350.23 EDO08120.1 - 0.062 13.3 0.4 0.29 11.2 0.1 2.1 2 0 0 2 2 2 0 Dynamin family T2SSE PF00437.20 EDO08120.1 - 0.08 12.0 0.5 4.1 6.4 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF815 PF05673.13 EDO08120.1 - 0.088 11.9 0.4 0.59 9.2 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF815) PhoH PF02562.16 EDO08120.1 - 0.14 11.6 0.6 8.7 5.7 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein Roc PF08477.13 EDO08120.1 - 0.14 12.3 0.5 15 5.8 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 EDO08120.1 - 0.15 12.5 0.1 10 6.6 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA_25 PF13481.6 EDO08120.1 - 0.17 11.4 0.4 9 5.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 EDO08120.1 - 0.19 11.4 0.2 10 5.7 0.1 3.2 4 0 0 4 4 2 0 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.15 EDO08120.1 - 0.2 11.5 0.4 24 4.8 0.0 2.4 2 0 0 2 2 2 0 NTPase AAA_15 PF13175.6 EDO08120.1 - 0.24 11.0 0.6 1.1 8.9 0.3 2.0 2 0 0 2 2 2 0 AAA ATPase domain PRK PF00485.18 EDO08120.1 - 0.28 10.9 0.8 5.8 6.6 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family ALMS_repeat PF18727.1 EDO08122.1 - 0.46 10.4 4.5 3.4 7.6 1.5 2.3 1 1 1 2 2 2 0 Alstrom syndrome repeat CorA PF01544.18 EDO08123.1 - 0.087 12.1 1.6 0.24 10.7 1.5 1.7 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF1411 PF07199.11 EDO08123.1 - 0.22 11.1 0.1 0.22 11.1 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1411) XRN_M PF17846.1 EDO08123.1 - 0.51 9.2 19.2 0.82 8.6 19.2 1.4 1 0 0 1 1 1 0 Xrn1 helical domain DUF5427 PF10310.9 EDO08123.1 - 4.4 6.1 29.9 7.4 5.4 29.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF1411 PF07199.11 EDO08126.1 - 0.0023 17.6 0.1 0.0077 15.9 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1411) YscO PF07321.12 EDO08126.1 - 0.031 14.2 0.1 0.076 13.0 0.1 1.6 1 1 1 2 2 2 0 Type III secretion protein YscO DUF1411 PF07199.11 EDO08127.1 - 0.0057 16.3 0.0 0.18 11.5 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1411) DUF1411 PF07199.11 EDO08128.1 - 0.12 12.1 0.0 0.18 11.4 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1411) YCII PF03795.14 EDO08130.1 - 0.0065 16.8 0.0 0.086 13.3 0.0 2.3 2 0 0 2 2 2 1 YCII-related domain ANAPC4_WD40 PF12894.7 EDO08131.1 - 6e-10 39.3 0.1 0.14 12.4 0.0 5.3 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO08131.1 - 4.1e-06 27.4 9.7 0.0078 17.0 0.1 6.3 6 0 0 6 6 6 2 WD domain, G-beta repeat PD40 PF07676.12 EDO08131.1 - 0.16 11.9 0.8 33 4.6 0.0 3.9 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat LSM14 PF12701.7 EDO08132.1 - 6e-27 93.6 0.0 1.3e-26 92.5 0.0 1.6 1 0 0 1 1 1 1 Scd6-like Sm domain SM-ATX PF14438.6 EDO08132.1 - 2e-08 34.2 0.0 3.9e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain FDF PF09532.10 EDO08132.1 - 0.011 16.5 3.3 0.011 16.5 3.3 2.4 2 0 0 2 2 2 0 FDF domain Ion_trans PF00520.31 EDO08133.1 - 2.1e-13 50.1 21.9 2.7e-13 49.7 21.9 1.1 1 0 0 1 1 1 1 Ion transport protein AA_permease PF00324.21 EDO08133.1 - 0.21 10.1 11.4 0.13 10.8 1.1 2.6 2 1 1 3 3 3 0 Amino acid permease PI31_Prot_C PF08577.11 EDO08134.1 - 0.0019 19.3 9.5 0.0019 19.3 9.5 2.6 2 1 1 3 3 3 1 PI31 proteasome regulator TruB_N PF01509.18 EDO08135.1 - 7.8e-38 130.2 0.3 4.3e-37 127.8 0.3 1.9 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 EDO08135.1 - 7.6e-07 29.2 0.1 1.8e-06 28.0 0.0 1.7 2 0 0 2 2 2 1 tRNA pseudouridylate synthase B C-terminal domain EF-hand_7 PF13499.6 EDO08136.1 - 3.3e-05 24.2 0.2 0.13 12.8 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EDO08136.1 - 0.016 15.1 0.0 0.87 9.7 0.0 3.1 3 0 0 3 3 3 0 EF-hand domain EF-hand_1 PF00036.32 EDO08136.1 - 0.017 14.6 0.1 0.52 10.0 0.0 3.3 3 0 0 3 3 3 0 EF hand EF-hand_8 PF13833.6 EDO08136.1 - 0.037 13.9 0.1 5.4 6.9 0.0 2.8 2 0 0 2 2 2 0 EF-hand domain pair Iwr1 PF08574.10 EDO08136.1 - 0.49 11.4 4.3 1.5 9.9 4.3 1.8 1 0 0 1 1 1 0 Transcription factor Iwr1 Pkinase PF00069.25 EDO08137.1 - 3e-63 213.7 0.0 3.5e-63 213.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO08137.1 - 1.1e-35 123.1 0.0 1.4e-35 122.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO08137.1 - 0.0014 18.0 0.0 0.0021 17.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RRM_1 PF00076.22 EDO08138.1 - 9.1e-21 73.5 0.2 1.6e-09 37.5 0.0 2.4 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDO08138.1 - 0.00019 21.1 0.0 0.14 11.8 0.0 2.1 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PCI PF01399.27 EDO08139.1 - 1.5e-11 44.7 0.2 1.5e-11 44.7 0.2 2.3 2 0 0 2 2 2 1 PCI domain eIF3_N PF09440.10 EDO08139.1 - 0.0078 16.7 0.8 0.024 15.1 0.8 2.0 1 1 0 1 1 1 1 eIF3 subunit 6 N terminal domain COX_ARM PF06481.14 EDO08139.1 - 0.095 12.6 0.1 0.4 10.6 0.0 2.0 2 0 0 2 2 2 0 COX Aromatic Rich Motif ANAPC3 PF12895.7 EDO08139.1 - 0.16 12.3 0.5 0.59 10.4 0.1 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Surp PF01805.20 EDO08143.1 - 5.1e-39 132.1 0.3 7.9e-19 67.4 0.0 2.6 2 0 0 2 2 2 2 Surp module PRP21_like_P PF12230.8 EDO08143.1 - 7.4e-39 133.9 1.7 1.3e-38 133.1 1.7 1.3 1 0 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein FinO_N PF12602.8 EDO08143.1 - 0.23 11.8 0.1 0.23 11.8 0.1 1.9 2 0 0 2 2 2 0 Fertility inhibition protein N terminal MscS_TM PF12794.7 EDO08143.1 - 0.28 10.0 0.4 0.42 9.4 0.4 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 ABC_tran PF00005.27 EDO08144.1 - 2.6e-32 112.2 0.0 8.7e-18 65.2 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EDO08144.1 - 6.1e-12 45.8 20.4 6.1e-12 45.8 20.4 3.2 3 0 0 3 3 3 2 ABC transporter transmembrane region AAA_29 PF13555.6 EDO08144.1 - 4.9e-06 26.2 1.8 0.088 12.6 0.1 2.9 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EDO08144.1 - 1.1e-05 25.4 0.5 0.94 9.2 0.0 3.9 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EDO08144.1 - 4.1e-05 23.7 0.0 0.00014 22.0 0.0 1.9 2 0 0 2 2 1 1 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 EDO08144.1 - 0.00022 21.6 0.1 0.2 12.0 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 EDO08144.1 - 0.00025 20.8 0.3 0.057 13.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EDO08144.1 - 0.00029 20.2 0.3 0.12 11.6 0.1 2.4 2 0 0 2 2 2 1 Zeta toxin Dynamin_N PF00350.23 EDO08144.1 - 0.00038 20.5 2.1 0.016 15.3 0.4 2.4 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EDO08144.1 - 0.00041 20.4 0.4 0.071 13.2 0.1 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDO08144.1 - 0.00066 19.6 2.5 0.24 11.3 0.0 2.8 3 0 0 3 3 2 2 RsgA GTPase AAA_22 PF13401.6 EDO08144.1 - 0.00067 19.9 0.0 0.31 11.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EDO08144.1 - 0.0037 16.4 0.2 0.87 8.6 0.1 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_23 PF13476.6 EDO08144.1 - 0.0052 17.3 4.8 0.56 10.7 0.6 2.5 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 EDO08144.1 - 0.0056 16.6 0.9 3.3 7.6 0.1 2.7 2 0 0 2 2 2 1 NACHT domain DnaB_C PF03796.15 EDO08144.1 - 0.0064 15.9 0.0 0.52 9.6 0.0 2.4 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain cobW PF02492.19 EDO08144.1 - 0.01 15.4 1.0 4 7.0 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 EDO08144.1 - 0.015 15.0 0.2 5 6.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EDO08144.1 - 0.023 13.9 0.9 0.27 10.4 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain TsaE PF02367.17 EDO08144.1 - 0.056 13.4 0.2 6.2 6.8 0.1 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SMC_N PF02463.19 EDO08144.1 - 0.06 12.8 1.1 2.9 7.3 0.2 2.8 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain MeaB PF03308.16 EDO08144.1 - 0.061 12.3 0.9 0.12 11.3 0.1 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB PRK PF00485.18 EDO08144.1 - 0.063 13.0 0.6 0.87 9.3 0.0 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family NTPase_1 PF03266.15 EDO08144.1 - 0.066 13.1 0.7 6 6.8 0.1 2.4 2 0 0 2 2 2 0 NTPase AAA_18 PF13238.6 EDO08144.1 - 0.072 13.6 0.1 18 5.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain MobB PF03205.14 EDO08144.1 - 0.086 12.7 0.9 12 5.9 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B ATPase_2 PF01637.18 EDO08144.1 - 0.088 12.7 0.1 5.1 6.9 0.0 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea KAP_NTPase PF07693.14 EDO08144.1 - 0.13 11.5 0.0 4.6 6.4 0.0 2.4 2 0 0 2 2 2 0 KAP family P-loop domain ATP_bind_1 PF03029.17 EDO08144.1 - 0.13 12.0 2.7 5.5 6.7 0.0 2.8 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein FtsK_SpoIIIE PF01580.18 EDO08144.1 - 0.15 11.4 0.7 4.6 6.5 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family RNA_helicase PF00910.22 EDO08144.1 - 0.16 12.4 0.1 37 4.8 0.0 2.8 2 0 0 2 2 2 0 RNA helicase DUF2791 PF10923.8 EDO08144.1 - 0.16 10.7 0.0 6 5.6 0.0 2.4 2 0 0 2 2 2 0 P-loop Domain of unknown function (DUF2791) AAA_25 PF13481.6 EDO08144.1 - 0.18 11.4 0.0 17 4.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 EDO08144.1 - 0.22 11.6 3.0 0.3 11.1 0.1 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain DUF1411 PF07199.11 EDO08145.1 - 0.012 15.3 0.3 0.04 13.6 0.1 1.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1411) DUF445 PF04286.12 EDO08145.1 - 0.036 13.9 2.7 0.058 13.2 2.7 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF445) DUF2281 PF10047.9 EDO08145.1 - 0.066 13.9 1.1 3.6 8.4 0.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2281) DUF2617 PF10936.8 EDO08145.1 - 0.1 12.7 0.0 18 5.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF2617 SUIM_assoc PF16619.5 EDO08145.1 - 0.69 10.0 8.4 0.19 11.8 2.0 2.8 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DUF1411 PF07199.11 EDO08146.1 - 1.1e-05 25.2 0.2 0.0068 16.1 0.2 2.6 3 0 0 3 3 3 2 Protein of unknown function (DUF1411) PH_3 PF14593.6 EDO08146.1 - 0.085 13.0 0.1 0.18 11.9 0.1 1.5 1 0 0 1 1 1 0 PH domain Cep57_MT_bd PF06657.13 EDO08147.1 - 0.011 16.2 2.2 0.049 14.1 0.2 2.5 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF357 PF04010.13 EDO08147.1 - 0.2 11.8 3.8 0.27 11.3 0.1 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF357) DUF1409 PF07197.12 EDO08148.1 - 0.025 14.4 0.5 0.33 10.9 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1409) ThiF PF00899.21 EDO08149.1 - 1.1e-44 152.6 0.0 1.2e-35 123.0 0.0 3.3 2 1 1 3 3 3 2 ThiF family UBA_e1_thiolCys PF10585.9 EDO08149.1 - 5e-06 26.6 3.9 0.047 13.6 0.6 2.9 1 1 1 3 3 3 3 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.20 EDO08149.1 - 0.00014 22.0 0.3 0.14 12.2 0.0 2.6 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase Pox_M2 PF04887.12 EDO08149.1 - 0.011 15.3 0.6 0.027 14.0 0.6 1.6 1 0 0 1 1 1 0 Poxvirus M2 protein NAD_binding_7 PF13241.6 EDO08149.1 - 0.059 13.8 0.4 0.67 10.4 0.1 3.0 3 0 0 3 3 3 0 Putative NAD(P)-binding DUF4974 PF16344.5 EDO08149.1 - 4.7 7.3 5.4 2.8 8.0 0.2 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4974) DEAD PF00270.29 EDO08150.1 - 2.5e-37 128.3 0.1 1.7e-36 125.6 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO08150.1 - 3e-28 98.4 4.2 1.5e-27 96.1 0.2 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO08150.1 - 0.00041 20.4 0.6 0.011 15.8 0.0 2.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit ANTAR PF03861.14 EDO08150.1 - 0.019 14.8 0.2 0.044 13.6 0.2 1.5 1 0 0 1 1 1 0 ANTAR domain eIF-6 PF01912.18 EDO08151.1 - 4.6e-71 238.3 1.9 2e-69 232.9 1.9 2.2 1 1 0 1 1 1 1 eIF-6 family DUF4911 PF16256.5 EDO08151.1 - 0.02 14.9 0.2 6.6 6.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4911) AP_endonuc_2 PF01261.24 EDO08152.1 - 3.2e-26 92.1 0.0 7e-26 91.0 0.0 1.5 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel HTH_20 PF12840.7 EDO08154.1 - 0.032 14.3 0.1 0.065 13.3 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain WD40 PF00400.32 EDO08155.1 - 1.6e-09 38.2 9.0 0.1 13.5 0.2 6.4 8 0 0 8 8 8 3 WD domain, G-beta repeat Atg8 PF02991.16 EDO08156.1 - 2.1e-17 63.2 0.1 5.2e-17 61.9 0.1 1.6 1 1 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EDO08156.1 - 0.0024 18.2 0.1 0.016 15.6 0.1 1.9 1 1 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 tRNA_Me_trans PF03054.16 EDO08157.1 - 6.1e-99 331.2 0.0 7.9e-99 330.8 0.0 1.1 1 0 0 1 1 1 1 tRNA methyl transferase SufE PF02657.15 EDO08157.1 - 4.5e-10 39.4 0.0 1.6e-09 37.7 0.0 1.9 2 0 0 2 2 2 1 Fe-S metabolism associated domain ThiI PF02568.14 EDO08157.1 - 1e-05 25.2 0.0 5.7e-05 22.8 0.0 2.0 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) QueC PF06508.13 EDO08157.1 - 0.013 15.0 0.0 0.16 11.4 0.0 2.2 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC NPHI_C PF08469.10 EDO08158.1 - 0.072 13.1 0.0 0.61 10.0 0.0 2.0 2 0 0 2 2 2 0 Nucleoside triphosphatase I C-terminal Diphthamide_syn PF01866.17 EDO08159.1 - 3.5e-101 338.6 0.0 4.7e-101 338.2 0.0 1.2 1 0 0 1 1 1 1 Putative diphthamide synthesis protein SET PF00856.28 EDO08161.1 - 1.3e-16 61.4 1.2 1.3e-16 61.4 1.2 3.0 3 2 0 3 3 3 1 SET domain LSM PF01423.22 EDO08162.1 - 2.7e-19 68.6 0.0 3.3e-19 68.3 0.0 1.1 1 0 0 1 1 1 1 LSM domain Imm1 PF14430.6 EDO08162.1 - 0.011 16.4 0.0 0.019 15.6 0.0 1.6 1 1 0 1 1 1 0 Immunity protein Imm1 SM-ATX PF14438.6 EDO08162.1 - 0.16 12.1 0.0 0.21 11.7 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain Lon_C PF05362.13 EDO08163.1 - 8.7e-61 205.0 0.8 2.9e-52 177.2 0.0 2.7 3 0 0 3 3 3 2 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 EDO08163.1 - 2.6e-27 96.1 0.0 4.9e-27 95.2 0.0 1.4 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 EDO08163.1 - 7.6e-21 74.9 0.0 5.1e-20 72.2 0.0 2.3 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EDO08163.1 - 1.4e-06 28.3 0.0 3.1e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 EDO08163.1 - 1.5e-06 28.1 0.0 3.3e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_2 PF07724.14 EDO08163.1 - 1.6e-05 25.1 0.0 4.6e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 EDO08163.1 - 5.3e-05 23.0 0.0 0.00014 21.7 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_PrkA PF08298.11 EDO08163.1 - 5.9e-05 22.1 0.0 0.0001 21.3 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain AAA_22 PF13401.6 EDO08163.1 - 0.00011 22.5 0.1 0.002 18.4 0.1 2.7 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.6 EDO08163.1 - 0.00012 22.5 0.0 0.00041 20.8 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EDO08163.1 - 0.00021 21.9 0.2 0.00082 19.9 0.0 2.1 2 0 0 2 2 1 1 AAA domain RuvB_N PF05496.12 EDO08163.1 - 0.00053 19.8 0.0 0.0018 18.0 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EDO08163.1 - 0.0033 16.7 0.0 0.0073 15.5 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain ABC_tran PF00005.27 EDO08163.1 - 0.015 15.8 0.0 3.9 8.0 0.1 3.0 2 1 0 2 2 2 0 ABC transporter NTPase_1 PF03266.15 EDO08163.1 - 0.024 14.5 0.0 0.12 12.2 0.0 2.2 1 1 1 2 2 2 0 NTPase Rad17 PF03215.15 EDO08163.1 - 0.028 14.4 0.0 0.12 12.3 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain Mg_chelatase PF01078.21 EDO08163.1 - 0.043 13.2 0.1 0.13 11.6 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RsgA_GTPase PF03193.16 EDO08163.1 - 0.044 13.7 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_15 PF13175.6 EDO08163.1 - 0.046 13.4 1.8 0.95 9.1 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.22 EDO08163.1 - 0.085 13.3 0.0 0.24 11.8 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_19 PF13245.6 EDO08163.1 - 0.14 12.5 0.2 0.51 10.7 0.0 2.1 2 0 0 2 2 1 0 AAA domain Nsp1_C PF05064.13 EDO08164.1 - 2.1e-06 27.5 3.8 2.1e-06 27.5 3.8 2.6 2 1 1 3 3 3 1 Nsp1-like C-terminal region IFT57 PF10498.9 EDO08164.1 - 0.0011 18.0 7.0 0.0016 17.5 7.0 1.2 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Arfaptin PF06456.13 EDO08164.1 - 0.002 17.8 7.0 0.35 10.4 0.7 2.1 1 1 1 2 2 2 2 Arfaptin-like domain TelA PF05816.11 EDO08164.1 - 0.0033 16.5 5.6 0.0053 15.9 5.6 1.2 1 0 0 1 1 1 1 Toxic anion resistance protein (TelA) Fez1 PF06818.15 EDO08164.1 - 0.0042 17.6 4.1 0.0074 16.8 4.1 1.3 1 0 0 1 1 1 1 Fez1 GCSF PF16647.5 EDO08164.1 - 0.0088 15.9 0.4 0.016 15.0 0.4 1.4 1 0 0 1 1 1 1 Granulocyte colony-stimulating factor OmpH PF03938.14 EDO08164.1 - 0.021 15.2 6.7 0.021 15.2 4.1 1.9 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Dynactin_p22 PF07426.11 EDO08164.1 - 0.028 14.3 5.7 1.8 8.4 0.2 2.4 2 1 0 2 2 2 0 Dynactin subunit p22 DUF4164 PF13747.6 EDO08164.1 - 0.033 14.5 5.2 0.13 12.6 0.5 2.6 2 1 1 3 3 2 0 Domain of unknown function (DUF4164) DUF1664 PF07889.12 EDO08164.1 - 0.061 13.4 2.9 0.41 10.7 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) CCDC-167 PF15188.6 EDO08164.1 - 0.068 13.5 7.4 0.041 14.2 3.3 2.3 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 ACP_PD PF04336.12 EDO08164.1 - 0.092 13.2 1.3 0.19 12.1 1.3 1.6 1 1 0 1 1 1 0 Acyl carrier protein phosphodiesterase DUF4407 PF14362.6 EDO08164.1 - 0.11 11.9 3.2 0.16 11.3 3.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF948 PF06103.11 EDO08164.1 - 0.17 12.1 2.0 10 6.5 0.1 3.1 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DASH_Dad3 PF08656.10 EDO08164.1 - 0.23 11.6 10.3 0.14 12.3 5.7 2.8 2 1 2 4 4 3 0 DASH complex subunit Dad3 GAS PF13851.6 EDO08164.1 - 0.26 10.6 11.7 0.049 13.0 4.6 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Fib_alpha PF08702.10 EDO08164.1 - 0.4 10.9 8.5 2.7 8.2 1.2 2.7 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Med4 PF10018.9 EDO08164.1 - 1 9.0 7.6 1.1 8.9 5.4 2.2 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Mod_r PF07200.13 EDO08164.1 - 1 9.4 11.7 0.94 9.6 9.7 1.9 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Nucleoporin_FG PF13634.6 EDO08164.1 - 1.2 10.1 74.7 4.6 8.2 25.9 3.7 1 1 2 3 3 3 0 Nucleoporin FG repeat region CENP-F_leu_zip PF10473.9 EDO08164.1 - 1.2 9.1 14.1 4.4 7.3 10.2 2.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SesA PF17107.5 EDO08164.1 - 1.6 9.0 5.3 1.3 9.2 0.8 2.8 1 1 2 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF16 PF01519.16 EDO08164.1 - 1.6 9.3 6.4 21 5.7 6.3 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 Laminin_II PF06009.12 EDO08164.1 - 1.6 8.7 9.5 6 6.9 2.5 2.7 2 1 0 2 2 2 0 Laminin Domain II LPP PF04728.13 EDO08164.1 - 1.6 9.2 5.4 20 5.6 0.2 3.0 3 0 0 3 3 2 0 Lipoprotein leucine-zipper Csm1_N PF18504.1 EDO08164.1 - 1.8 8.9 9.4 7 7.1 1.6 3.2 3 0 0 3 3 3 0 Csm1 N-terminal domain Spectrin PF00435.21 EDO08164.1 - 2.1 8.9 6.6 3.6 8.1 5.0 2.1 1 1 0 1 1 1 0 Spectrin repeat Occludin_ELL PF07303.13 EDO08164.1 - 2.2 9.1 7.3 8.8 7.1 5.5 2.6 1 1 1 2 2 2 0 Occludin homology domain SKA2 PF16740.5 EDO08164.1 - 2.3 8.0 8.9 21 5.0 6.5 3.0 1 1 2 3 3 3 0 Spindle and kinetochore-associated protein 2 K-box PF01486.17 EDO08164.1 - 2.5 8.3 10.6 0.86 9.8 7.5 1.8 2 0 0 2 2 1 0 K-box region UPF0242 PF06785.11 EDO08164.1 - 3.2 7.8 11.3 11 6.1 11.3 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4298 PF14131.6 EDO08164.1 - 4.7 7.2 8.4 4.3 7.4 0.5 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4298) APG6_N PF17675.1 EDO08164.1 - 5.6 7.5 13.0 1.9 9.0 9.7 1.8 2 0 0 2 2 2 0 Apg6 coiled-coil region YabA PF06156.13 EDO08164.1 - 5.8 7.6 7.6 30 5.3 7.3 2.2 1 1 1 2 2 2 0 Initiation control protein YabA CLZ PF16526.5 EDO08164.1 - 6 7.3 10.2 5.1 7.5 1.1 3.0 2 1 2 4 4 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels BLOC1_2 PF10046.9 EDO08164.1 - 6.2 7.2 14.9 10 6.5 4.1 3.9 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FapA PF03961.13 EDO08164.1 - 6.6 5.2 9.2 13 4.3 9.2 1.6 1 1 0 1 1 1 0 Flagellar Assembly Protein A DHR10 PF18595.1 EDO08164.1 - 7.7 6.6 10.9 55 3.8 8.1 2.5 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain GrpE PF01025.19 EDO08164.1 - 8.8 6.0 8.2 11 5.6 6.9 1.8 1 1 0 2 2 2 0 GrpE RNA_pol_Rpb4 PF03874.16 EDO08165.1 - 5.1e-14 52.7 0.3 7.5e-14 52.1 0.3 1.3 1 1 0 1 1 1 1 RNA polymerase Rpb4 PCI PF01399.27 EDO08166.1 - 2.1e-08 34.6 0.0 5.1e-08 33.4 0.0 1.7 1 0 0 1 1 1 1 PCI domain TPR_2 PF07719.17 EDO08166.1 - 0.0057 16.7 1.3 0.01 15.9 0.5 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EDO08166.1 - 0.066 13.3 0.0 1.4 9.2 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EDO08166.1 - 0.47 10.4 2.2 0.48 10.3 0.6 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat RRP7 PF12923.7 EDO08167.1 - 7e-07 29.4 0.0 9.9e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain VESA1_N PF12785.7 EDO08168.1 - 3.8e-199 662.4 41.0 3.8e-199 662.4 41.0 3.2 3 1 0 3 3 3 1 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO08169.1 - 9.6e-23 80.9 32.3 1.8e-11 43.7 0.1 4.1 2 1 2 4 4 4 3 Variant erythrocyte surface antigen-1 Hydrolase_4 PF12146.8 EDO08170.1 - 5.3e-06 25.9 0.1 0.0071 15.6 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EDO08170.1 - 1.7e-05 24.7 0.3 0.00054 19.8 0.3 2.5 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase LIP PF03583.14 EDO08170.1 - 0.0011 18.4 0.0 0.014 14.8 0.0 2.1 2 0 0 2 2 2 1 Secretory lipase Abhydrolase_3 PF07859.13 EDO08170.1 - 0.0029 17.5 0.0 0.0063 16.4 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF1057 PF06342.12 EDO08170.1 - 0.018 14.1 0.0 0.025 13.6 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Peptidase_S9 PF00326.21 EDO08170.1 - 0.023 14.2 0.0 0.032 13.7 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family FSH1 PF03959.13 EDO08170.1 - 0.044 13.5 0.0 0.066 12.9 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 EDO08170.1 - 0.061 13.9 0.0 0.09 13.4 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EDO08170.1 - 0.11 12.1 0.1 1.2 8.7 0.0 2.1 1 1 1 2 2 2 0 alpha/beta hydrolase fold Thioredoxin_6 PF13848.6 EDO08171.1 - 1.5e-06 28.2 0.2 0.75 9.7 0.0 3.4 3 1 0 3 3 3 3 Thioredoxin-like domain Thioredoxin PF00085.20 EDO08171.1 - 2.9e-06 27.2 0.0 5.7e-05 23.1 0.0 2.8 3 1 1 4 4 4 1 Thioredoxin Thioredoxin_2 PF13098.6 EDO08171.1 - 9.7e-05 22.8 0.0 0.049 14.1 0.0 2.7 2 1 0 2 2 2 2 Thioredoxin-like domain KaiB PF07689.12 EDO08171.1 - 0.0029 17.3 0.0 0.0081 15.9 0.0 1.7 1 0 0 1 1 1 1 KaiB domain Thioredoxin_8 PF13905.6 EDO08171.1 - 0.003 17.9 0.2 0.057 13.8 0.0 2.7 3 0 0 3 3 3 1 Thioredoxin-like OST3_OST6 PF04756.13 EDO08171.1 - 0.0062 15.9 0.2 0.087 12.2 0.0 2.6 2 2 1 3 3 3 1 OST3 / OST6 family, transporter family mRNA_cap_enzyme PF01331.19 EDO08172.1 - 4.9e-47 160.3 0.0 6.8e-47 159.8 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 EDO08172.1 - 1.8e-14 54.3 0.1 1.6e-13 51.2 0.1 2.2 1 1 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 EDO08172.1 - 7.5e-05 22.5 0.0 0.19 11.4 0.0 2.3 1 1 1 2 2 2 2 ATP dependent DNA ligase domain ABC1 PF03109.16 EDO08173.1 - 2.9e-25 88.8 0.1 7e-25 87.5 0.1 1.6 1 0 0 1 1 1 1 ABC1 family Beta-lactamase PF00144.24 EDO08173.1 - 2.1e-22 79.8 0.0 2.7e-20 72.9 0.0 2.2 2 0 0 2 2 2 2 Beta-lactamase APH PF01636.23 EDO08173.1 - 0.016 15.2 0.3 0.029 14.3 0.3 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Metallophos PF00149.28 EDO08174.1 - 4e-39 135.2 0.1 5.1e-39 134.9 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EDO08174.1 - 9.5e-19 67.6 1.1 9.5e-19 67.6 1.1 1.8 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain zf-CCHC_2 PF13696.6 EDO08175.1 - 3.4e-06 26.7 8.5 3.4e-06 26.7 8.5 1.9 2 0 0 2 2 2 1 Zinc knuckle zf-C3HC4_4 PF15227.6 EDO08175.1 - 0.00029 20.9 11.6 0.00029 20.9 11.6 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EDO08175.1 - 0.0011 18.9 4.5 0.0019 18.2 3.0 2.3 1 1 0 1 1 1 1 RING-type zinc-finger Zn_ribbon_SprT PF17283.2 EDO08175.1 - 0.02 14.8 5.6 0.58 10.1 1.6 2.9 2 0 0 2 2 2 0 SprT-like zinc ribbon domain PhnA_Zn_Ribbon PF08274.12 EDO08175.1 - 0.13 12.2 4.3 0.53 10.3 0.9 2.8 2 0 0 2 2 2 0 PhnA Zinc-Ribbon zf-RING_2 PF13639.6 EDO08175.1 - 0.36 11.2 16.6 0.052 13.9 10.3 2.8 2 0 0 2 2 2 0 Ring finger domain zf-CCHC PF00098.23 EDO08175.1 - 0.36 11.0 4.8 1.7 8.9 4.8 2.2 1 0 0 1 1 1 0 Zinc knuckle zf-RING_6 PF14835.6 EDO08175.1 - 0.87 9.5 7.5 2.2 8.2 7.5 1.7 1 1 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4 PF00097.25 EDO08175.1 - 2.6 8.0 17.8 0.22 11.4 11.4 2.7 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Ribosomal_S9 PF00380.19 EDO08176.1 - 3.7e-30 104.9 0.1 5.8e-30 104.3 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S9/S16 AT_hook PF02178.19 EDO08176.1 - 1.1 9.4 9.3 0.25 11.3 5.6 2.1 2 0 0 2 2 2 0 AT hook motif Nop53 PF07767.11 EDO08177.1 - 1e-25 91.0 16.0 2.2e-24 86.6 16.0 2.4 1 1 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) DUF4852 PF16144.5 EDO08177.1 - 2 8.6 5.1 25 5.0 1.1 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4852) RNA_pol_Rbc25 PF08292.12 EDO08178.1 - 1.3e-13 51.3 0.0 2e-13 50.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 EDO08178.1 - 1.6e-11 44.4 0.1 2.5e-11 43.8 0.1 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 UCH PF00443.29 EDO08179.1 - 1.9e-31 109.5 0.2 2.9e-31 108.9 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDO08179.1 - 2.4e-18 66.8 1.0 6.9e-18 65.3 1.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Proteasom_Rpn13 PF04683.13 EDO08180.1 - 1.4e-20 73.6 0.0 1.8e-20 73.3 0.0 1.1 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor Helicase_C_2 PF13307.6 EDO08182.1 - 1.3e-41 142.6 0.0 2.9e-41 141.5 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 EDO08182.1 - 6.4e-18 65.0 12.7 4.8e-06 26.3 3.7 4.0 2 1 0 3 3 3 3 DEAD_2 DEAD PF00270.29 EDO08182.1 - 3.3e-06 27.0 0.4 4.6e-05 23.3 0.0 2.7 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.15 EDO08182.1 - 0.00018 21.5 0.1 0.0052 16.8 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit RRM_1 PF00076.22 EDO08183.1 - 3.6e-40 135.6 0.1 2.6e-19 68.8 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO08183.1 - 3.2e-05 24.0 0.1 0.015 15.4 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif OB_RNB PF08206.11 EDO08183.1 - 4.2e-05 23.1 0.5 0.0086 15.7 0.1 2.4 2 0 0 2 2 2 2 Ribonuclease B OB domain RRM_5 PF13893.6 EDO08183.1 - 0.009 15.6 0.0 0.55 9.8 0.0 2.2 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 EDO08183.1 - 0.22 11.8 0.0 1.4 9.1 0.0 2.1 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter UDG PF03167.19 EDO08184.1 - 2.6e-22 79.5 0.0 4.3e-22 78.8 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily YTH PF04146.15 EDO08185.1 - 1.4e-33 116.2 1.0 6.2e-32 110.8 1.0 2.2 1 1 0 1 1 1 1 YT521-B-like domain Torus PF16131.5 EDO08185.1 - 5.5e-06 27.0 1.9 1.2e-05 26.0 0.2 2.2 1 1 1 2 2 2 1 Torus domain zf_CCCH_4 PF18345.1 EDO08185.1 - 5.2e-05 23.1 3.0 5.2e-05 23.1 3.0 3.2 2 1 0 2 2 2 1 Zinc finger domain zf-CCCH_4 PF18044.1 EDO08185.1 - 0.0032 17.2 0.9 0.0032 17.2 0.9 2.0 3 0 0 3 3 3 1 CCCH-type zinc finger zf-CCCH PF00642.24 EDO08185.1 - 0.0086 16.0 6.9 0.36 10.8 0.5 2.6 2 1 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Rap1_C PF11626.8 EDO08185.1 - 0.096 12.8 0.0 0.27 11.4 0.0 1.7 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain UMP1 PF05348.11 EDO08186.1 - 3.6e-14 53.0 0.0 4.3e-14 52.7 0.0 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 Ribosomal_60s PF00428.19 EDO08187.1 - 7.5e-24 84.1 7.3 9.4e-24 83.8 7.3 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein CAP_N PF01213.19 EDO08187.1 - 0.065 12.7 0.0 0.077 12.5 0.0 1.0 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DFP PF04127.15 EDO08188.1 - 6.6e-19 68.5 0.3 2.4e-08 34.0 0.1 2.1 2 0 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein DSPc PF00782.20 EDO08189.1 - 1.4e-18 67.0 0.0 2.1e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EDO08189.1 - 0.0064 16.1 0.0 0.0084 15.7 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF35_N PF12172.8 EDO08189.1 - 0.08 12.8 3.1 0.97 9.4 0.0 2.6 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) N2227 PF07942.12 EDO08190.1 - 4.9e-81 271.9 0.0 6.2e-81 271.6 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein Ribosomal_L9_N PF01281.19 EDO08191.1 - 4e-13 48.7 0.6 1.4e-12 46.9 0.1 2.1 2 0 0 2 2 2 1 Ribosomal protein L9, N-terminal domain Ribosomal_L9_C PF03948.14 EDO08191.1 - 0.0094 16.4 0.1 0.018 15.5 0.1 1.5 1 1 0 1 1 1 1 Ribosomal protein L9, C-terminal domain DcpS_C PF11969.8 EDO08192.1 - 6.7e-06 26.6 1.3 0.0034 17.9 1.3 2.3 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding PWI PF01480.17 EDO08193.1 - 4.2e-31 107.1 0.0 6.4e-31 106.5 0.0 1.3 1 0 0 1 1 1 1 PWI domain Macoilin PF09726.9 EDO08193.1 - 1.6 7.2 11.6 2 6.8 11.6 1.1 1 0 0 1 1 1 0 Macoilin family YTH PF04146.15 EDO08194.1 - 8.3e-37 126.7 0.0 3.5e-36 124.6 0.0 1.9 1 1 0 1 1 1 1 YT521-B-like domain EMP24_GP25L PF01105.24 EDO08195.1 - 3.8e-22 79.1 0.1 4.4e-22 78.9 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Stevor PF17410.2 EDO08195.1 - 0.37 10.3 2.6 0.2 11.2 0.9 1.4 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame Pox_MCEL PF03291.16 EDO08196.1 - 1.3e-43 149.5 0.2 1.7e-43 149.0 0.2 1.2 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 EDO08196.1 - 3.2e-11 43.8 0.0 8.4e-11 42.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDO08196.1 - 2e-08 34.8 0.0 4.8e-08 33.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDO08196.1 - 3.2e-08 33.6 0.0 6.1e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDO08196.1 - 4.9e-08 32.9 0.0 9.2e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDO08196.1 - 7.4e-08 33.1 0.0 2e-07 31.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain mRNA_triPase PF02940.15 EDO08196.1 - 0.0033 17.2 0.0 0.0074 16.0 0.0 1.5 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain LCCL PF03815.19 EDO08197.1 - 1.1e-23 83.1 0.9 3.6e-23 81.5 0.9 1.9 1 0 0 1 1 1 1 LCCL domain F5_F8_type_C PF00754.25 EDO08197.1 - 6e-15 55.5 0.7 3.8e-07 30.3 0.1 2.6 2 0 0 2 2 2 2 F5/8 type C domain Ricin_B_lectin PF00652.22 EDO08197.1 - 9.2e-08 32.4 0.1 6.5e-07 29.6 0.1 2.4 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain COLFI PF01410.18 EDO08197.1 - 4.2e-05 23.0 2.5 6.5e-05 22.3 0.2 2.3 1 1 1 2 2 2 1 Fibrillar collagen C-terminal domain DUF1080 PF06439.11 EDO08197.1 - 0.00015 22.0 0.0 0.00072 19.7 0.0 2.1 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1080) THOC7 PF05615.13 EDO08197.1 - 0.0031 17.8 5.2 0.12 12.6 0.1 2.4 2 0 0 2 2 2 2 Tho complex subunit 7 Fibrinogen_C PF00147.18 EDO08197.1 - 0.041 13.7 0.0 0.13 12.0 0.0 1.9 1 0 0 1 1 1 0 Fibrinogen beta and gamma chains, C-terminal globular domain Rxt3 PF08642.10 EDO08197.1 - 0.076 13.8 0.1 0.54 11.0 0.1 2.2 1 1 1 2 2 2 0 Histone deacetylation protein Rxt3 SKA1 PF07160.12 EDO08197.1 - 4.8 7.0 6.0 4.2 7.2 1.2 2.3 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 DUF3161 PF11362.8 EDO08198.1 - 1.2e-12 47.6 0.4 2.9e-12 46.4 0.1 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF3161) SKA2 PF16740.5 EDO08198.1 - 4.9e-09 36.0 1.5 7.5e-09 35.4 0.9 1.6 1 1 1 2 2 2 1 Spindle and kinetochore-associated protein 2 Nas2_N PF18265.1 EDO08198.1 - 0.017 15.0 0.8 1.5 8.8 0.2 2.5 2 0 0 2 2 2 0 Nas2 N_terminal domain DUF4495 PF14906.6 EDO08198.1 - 0.052 12.6 0.1 0.054 12.6 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4495) DUF148 PF02520.17 EDO08199.1 - 0.00028 21.0 6.9 0.21 11.7 0.4 3.0 2 1 1 3 3 3 2 Domain of unknown function DUF148 Syntaxin-6_N PF09177.11 EDO08199.1 - 0.0052 17.3 6.8 0.59 10.7 2.9 3.4 2 1 0 2 2 2 1 Syntaxin 6, N-terminal Vps53_N PF04100.12 EDO08199.1 - 0.011 14.7 1.8 0.011 14.7 1.8 2.1 1 1 0 2 2 2 0 Vps53-like, N-terminal Glyco_transf_8 PF01501.20 EDO08199.1 - 0.013 15.1 0.1 0.017 14.7 0.1 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 8 Tup_N PF08581.10 EDO08199.1 - 0.02 15.2 6.0 0.46 10.8 0.4 3.2 2 1 1 3 3 3 0 Tup N-terminal Syntaxin PF00804.25 EDO08199.1 - 0.034 13.8 13.4 0.49 10.0 13.4 2.3 1 1 0 1 1 1 0 Syntaxin Vac_Fusion PF02346.16 EDO08199.1 - 0.037 13.7 2.8 6.9 6.4 0.0 2.7 2 1 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 Med9 PF07544.13 EDO08199.1 - 0.039 14.1 8.4 0.077 13.1 0.6 3.0 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 V-SNARE PF05008.15 EDO08199.1 - 0.06 13.7 7.1 3 8.3 0.1 3.6 2 2 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus CCDC-167 PF15188.6 EDO08199.1 - 0.063 13.6 4.4 7.2 7.0 2.0 2.6 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 FlaC_arch PF05377.11 EDO08199.1 - 0.075 13.4 4.2 4.5 7.8 0.0 4.1 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) TPR_MLP1_2 PF07926.12 EDO08199.1 - 0.11 12.6 13.1 0.02 15.0 7.2 2.4 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Nmad5 PF18757.1 EDO08199.1 - 0.15 12.2 4.0 0.26 11.4 3.9 1.4 1 1 0 1 1 1 0 Nucleotide modification associated domain 5 BLOC1_2 PF10046.9 EDO08199.1 - 0.24 11.7 7.2 1.1 9.6 0.2 3.2 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.12 EDO08199.1 - 0.34 11.4 5.1 1.1 9.7 0.1 2.9 3 0 0 3 3 2 0 Nucleopolyhedrovirus P10 protein Tweety PF04906.13 EDO08199.1 - 0.77 8.4 9.2 0.6 8.7 0.1 2.9 1 1 2 3 3 3 0 Tweety Cob_adeno_trans PF01923.18 EDO08199.1 - 1 9.5 8.5 0.27 11.4 3.7 2.0 1 1 1 2 2 2 0 Cobalamin adenosyltransferase TMPIT PF07851.13 EDO08199.1 - 1.1 8.5 8.5 0.57 9.4 1.1 2.1 1 1 1 2 2 2 0 TMPIT-like protein CREPT PF16566.5 EDO08199.1 - 1.1 9.4 12.5 0.24 11.6 2.6 3.2 2 1 1 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour V_ATPase_I PF01496.19 EDO08199.1 - 1.7 6.5 10.6 3.6 5.4 10.5 1.5 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF16 PF01519.16 EDO08199.1 - 1.8 9.1 5.8 24 5.5 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function DUF16 DUF4665 PF15679.5 EDO08199.1 - 1.8 9.2 4.9 3.5 8.3 0.4 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4665) DUF1664 PF07889.12 EDO08199.1 - 2.5 8.1 13.0 3.1 7.9 0.9 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Ead_Ea22 PF13935.6 EDO08199.1 - 3.1 8.4 7.2 0.72 10.5 1.8 2.4 2 2 0 2 2 2 0 Ead/Ea22-like protein ACCA PF03255.14 EDO08199.1 - 3.2 7.6 8.8 2.1 8.2 1.5 3.0 2 1 1 3 3 3 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit ABC_tran_CTD PF16326.5 EDO08199.1 - 5.4 7.3 7.1 2.4 8.5 0.9 3.0 2 1 1 3 3 3 0 ABC transporter C-terminal domain Uso1_p115_C PF04871.13 EDO08199.1 - 8.7 6.7 10.5 0.84 10.0 1.9 2.7 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Ribosomal_L14 PF00238.19 EDO08200.1 - 2.6e-35 121.2 0.0 3e-35 120.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e tRNA-synt_1c PF00749.21 EDO08201.1 - 6.3e-97 324.2 0.0 2.7e-96 322.2 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EDO08201.1 - 3e-39 134.7 0.0 4.8e-39 134.0 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain PTPLA PF04387.14 EDO08202.1 - 2.2e-10 40.5 1.8 2.2e-10 40.5 1.8 1.5 2 0 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA HSA PF07529.13 EDO08203.1 - 0.0081 16.5 0.0 0.016 15.5 0.0 1.4 1 0 0 1 1 1 1 HSA Pkinase PF00069.25 EDO08204.1 - 2.9e-51 174.4 0.0 3e-38 131.7 0.0 2.3 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO08204.1 - 1.2e-22 80.5 0.0 3.8e-22 78.8 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase UPF0054 PF02130.17 EDO08204.1 - 0.12 12.2 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein family UPF0054 Glycos_transf_N PF04413.16 EDO08204.1 - 0.2 11.3 0.0 0.36 10.5 0.0 1.5 1 0 0 1 1 1 0 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) Thymidylate_kin PF02223.17 EDO08205.1 - 2e-36 125.4 0.0 2.4e-36 125.1 0.0 1.1 1 0 0 1 1 1 1 Thymidylate kinase AAA_28 PF13521.6 EDO08205.1 - 0.007 16.6 0.0 0.011 16.0 0.0 1.5 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 EDO08205.1 - 0.03 13.8 0.1 0.13 11.7 0.1 2.1 1 1 0 1 1 1 0 Chromatin associated protein KTI12 ABC_tran PF00005.27 EDO08206.1 - 3.6e-31 108.5 0.0 1e-16 61.7 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EDO08206.1 - 5.2e-18 65.7 40.2 1e-15 58.2 18.8 3.2 3 0 0 3 3 3 3 ABC transporter transmembrane region AAA_29 PF13555.6 EDO08206.1 - 2.9e-05 23.7 3.1 0.065 13.0 0.4 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EDO08206.1 - 2.9e-05 24.0 0.4 0.22 11.4 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 EDO08206.1 - 0.00054 20.5 4.7 0.41 11.1 0.7 2.4 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 EDO08206.1 - 0.0013 18.0 0.4 1.1 8.5 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin AAA_16 PF13191.6 EDO08206.1 - 0.0025 18.2 0.0 1.1 9.6 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 EDO08206.1 - 0.0027 17.8 2.6 0.3 11.2 0.4 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EDO08206.1 - 0.0041 17.2 3.1 0.034 14.2 0.2 2.5 2 0 0 2 2 2 1 Dynamin family AAA_30 PF13604.6 EDO08206.1 - 0.0048 16.6 0.5 2.2 8.0 0.1 2.3 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EDO08206.1 - 0.0093 15.9 1.3 0.79 9.6 0.1 2.7 2 0 0 2 2 2 1 NACHT domain T2SSE PF00437.20 EDO08206.1 - 0.01 14.9 0.7 0.49 9.4 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_22 PF13401.6 EDO08206.1 - 0.011 16.1 1.5 2.6 8.3 0.1 2.8 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EDO08206.1 - 0.015 14.9 0.0 5.8 6.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EDO08206.1 - 0.02 14.9 0.3 1.1 9.3 0.0 2.6 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 EDO08206.1 - 0.021 14.0 0.8 0.71 9.0 0.1 2.3 2 0 0 2 2 2 0 NB-ARC domain DnaB_C PF03796.15 EDO08206.1 - 0.036 13.4 0.0 1.9 7.8 0.0 2.3 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain AAA_21 PF13304.6 EDO08206.1 - 0.036 13.9 2.9 1.2 8.9 0.1 2.8 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system NTPase_1 PF03266.15 EDO08206.1 - 0.058 13.3 1.1 2.1 8.3 0.0 2.5 2 0 0 2 2 2 0 NTPase cobW PF02492.19 EDO08206.1 - 0.061 12.9 1.9 2.9 7.4 0.2 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 EDO08206.1 - 0.071 12.1 0.4 0.81 8.6 0.1 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_7 PF12775.7 EDO08206.1 - 0.071 12.6 1.1 0.35 10.4 0.1 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region SMC_N PF02463.19 EDO08206.1 - 0.075 12.5 3.0 1.2 8.6 0.3 2.6 3 0 0 3 3 2 0 RecF/RecN/SMC N terminal domain AAA_18 PF13238.6 EDO08206.1 - 0.078 13.5 0.0 13 6.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EDO08206.1 - 0.09 12.5 1.4 2.8 7.6 0.1 2.4 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EDO08206.1 - 0.093 12.6 2.7 0.8 9.6 0.1 2.9 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_19 PF13245.6 EDO08206.1 - 0.34 11.3 1.6 4.8 7.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 EDO08206.1 - 0.47 10.5 4.3 0.39 10.8 0.2 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain DUF1411 PF07199.11 EDO08207.1 - 0.00084 19.0 0.7 0.0016 18.1 0.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1411) zf-C2H2_assoc2 PF16624.5 EDO08207.1 - 0.032 15.2 3.7 0.032 15.2 3.7 1.9 2 0 0 2 2 2 0 Unstructured region upstream of a zinc-finger DUF1411 PF07199.11 EDO08209.1 - 0.016 14.9 1.6 0.027 14.1 0.0 2.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1411) MMU163 PF17119.5 EDO08209.1 - 0.89 8.7 7.3 1.4 8.0 7.3 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis NARP1 PF12569.8 EDO08209.1 - 1.8 7.4 16.5 2.6 6.9 16.5 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Hid1 PF12722.7 EDO08209.1 - 3.3 5.7 11.6 4 5.4 11.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF1411 PF07199.11 EDO08211.1 - 0.024 14.3 2.3 0.028 14.1 0.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1411) DUF445 PF04286.12 EDO08211.1 - 0.25 11.1 6.1 0.31 10.8 6.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) DUF4551 PF15087.6 EDO08211.1 - 0.28 10.0 5.3 0.36 9.6 5.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Hid1 PF12722.7 EDO08211.1 - 1.7 6.6 12.0 2.1 6.4 12.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4407 PF14362.6 EDO08211.1 - 2.1 7.6 8.6 2.9 7.1 8.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SAPS PF04499.15 EDO08211.1 - 7.7 5.2 12.4 9.6 4.9 12.4 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Nup88 PF10168.9 EDO08215.1 - 7e-05 20.9 0.0 7.9e-05 20.7 0.0 1.0 1 0 0 1 1 1 1 Nuclear pore component DUF1411 PF07199.11 EDO08215.1 - 0.003 17.2 0.2 0.0093 15.6 0.1 1.8 2 1 1 3 3 3 1 Protein of unknown function (DUF1411) DUF2281 PF10047.9 EDO08215.1 - 0.012 16.2 2.1 0.47 11.2 0.2 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2281) Nucleoporin_FG PF13634.6 EDO08216.1 - 8.8e-20 71.4 173.3 1.1e-08 35.8 34.8 6.4 2 1 4 6 6 6 4 Nucleoporin FG repeat region Ribosomal_L27A PF00828.19 EDO08217.1 - 6.1e-23 81.9 0.0 8e-23 81.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A TRAPP PF04051.16 EDO08218.1 - 5.4e-19 68.4 0.0 7.2e-19 68.0 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component FAST_1 PF06743.15 EDO08219.1 - 0.0016 18.3 1.7 2.5 8.1 0.1 3.9 3 1 1 4 4 4 2 FAST kinase-like protein, subdomain 1 Sedlin_N PF04628.13 EDO08222.1 - 3e-34 118.0 0.0 3.7e-34 117.7 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region PAP_assoc PF03828.19 EDO08223.1 - 0.0056 16.9 0.1 0.014 15.6 0.1 1.7 1 0 0 1 1 1 1 Cid1 family poly A polymerase Ribosomal_L27_C PF18471.1 EDO08223.1 - 0.018 14.5 0.0 0.065 12.6 0.0 1.8 2 0 0 2 2 2 0 Ribosomal L27 protein C-terminal domain Cpn10 PF00166.21 EDO08224.1 - 1.2e-31 108.6 0.1 2.8e-15 56.1 0.0 2.2 2 0 0 2 2 2 2 Chaperonin 10 Kd subunit tRNA-synt_1 PF00133.22 EDO08225.1 - 1.3e-205 684.2 0.0 1.7e-205 683.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EDO08225.1 - 3.7e-18 65.9 0.1 1.7e-17 63.8 0.0 2.2 3 0 0 3 3 3 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EDO08225.1 - 3.5e-16 58.9 1.2 9.9e-06 24.5 0.3 4.0 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EDO08225.1 - 0.0038 16.6 0.0 0.013 14.9 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain FRB_dom PF08771.11 EDO08226.1 - 0.016 15.6 0.2 0.041 14.3 0.0 1.8 2 0 0 2 2 2 0 FKBP12-rapamycin binding domain JAB PF01398.21 EDO08227.1 - 4.1e-07 30.0 0.0 3.6e-05 23.7 0.0 2.4 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Unstab_antitox PF09720.10 EDO08227.1 - 0.15 12.1 1.9 5 7.3 0.2 2.4 2 0 0 2 2 2 0 Putative addiction module component Ribosomal_L7Ae PF01248.26 EDO08229.1 - 3.1e-22 78.1 0.0 3.5e-22 77.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Urocanase_N PF17391.2 EDO08229.1 - 0.091 12.4 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Urocanase N-terminal domain APP_Cu_bd PF12924.7 EDO08229.1 - 0.13 13.0 0.0 0.23 12.2 0.0 1.6 1 1 0 1 1 1 0 Copper-binding of amyloid precursor, CuBD Adaptin_N PF01602.20 EDO08230.1 - 1.8e-112 376.6 0.7 2.7e-112 376.0 0.7 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EDO08230.1 - 8.2e-55 185.3 2.8 1.2e-54 184.7 0.0 2.8 5 0 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDO08230.1 - 1.2e-15 57.7 0.0 9.8e-09 35.5 0.0 5.0 4 1 1 5 5 4 3 HEAT repeats HEAT PF02985.22 EDO08230.1 - 1.9e-11 43.2 3.1 0.0032 17.6 0.0 5.2 5 1 1 6 6 6 2 HEAT repeat Arm PF00514.23 EDO08230.1 - 0.00029 20.8 0.0 0.041 13.9 0.0 4.2 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 EDO08230.1 - 0.0012 18.3 0.0 0.0055 16.2 0.0 2.0 2 0 0 2 2 2 1 Armadillo-like HEAT_EZ PF13513.6 EDO08230.1 - 0.0017 18.8 0.3 7 7.3 0.0 4.5 3 1 1 4 4 4 1 HEAT-like repeat Alpha_adaptinC2 PF02883.20 EDO08230.1 - 0.0029 17.9 0.3 0.0049 17.2 0.3 1.3 1 0 0 1 1 1 1 Adaptin C-terminal domain RTP1_C1 PF10363.9 EDO08230.1 - 0.0053 16.9 0.0 0.03 14.5 0.0 2.4 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 EDO08230.1 - 0.091 12.3 0.0 1.8 8.1 0.0 2.7 2 1 1 3 3 3 0 CLASP N terminal AP4E_app_platf PF14807.6 EDO08230.1 - 0.11 12.8 0.0 0.34 11.3 0.0 1.8 1 0 0 1 1 1 0 Adaptin AP4 complex epsilon appendage platform CSN8_PSD8_EIF3K PF10075.9 EDO08231.1 - 1e-19 71.0 0.0 1.4e-19 70.5 0.0 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Sybindin PF04099.12 EDO08233.1 - 1.7e-37 128.5 0.1 1.9e-37 128.4 0.1 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EDO08233.1 - 1.3e-06 28.6 0.0 1.3e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Cas_Cas1 PF01867.16 EDO08233.1 - 0.19 10.9 0.0 0.27 10.4 0.0 1.2 1 0 0 1 1 1 0 CRISPR associated protein Cas1 PI3_PI4_kinase PF00454.27 EDO08235.1 - 4e-44 151.3 0.0 7.2e-44 150.5 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase ubiquitin PF00240.23 EDO08235.1 - 0.14 11.9 0.0 0.41 10.4 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin family tRNA-synt_1 PF00133.22 EDO08236.1 - 4e-64 216.9 1.9 2.4e-29 102.1 0.4 3.1 3 0 0 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EDO08236.1 - 1.1e-12 47.4 0.8 7.4e-07 28.2 0.0 3.4 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EDO08236.1 - 0.0079 15.6 0.1 0.76 9.1 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.13 EDO08236.1 - 0.014 15.4 0.0 0.036 14.0 0.0 1.7 1 0 0 1 1 1 0 Anticodon-binding domain of tRNA zf-HC5HC2H_2 PF13832.6 EDO08237.1 - 3.7e-30 104.3 40.5 3.6e-18 65.7 5.2 4.9 4 1 1 5 5 5 3 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EDO08237.1 - 2e-12 47.2 12.2 5.5e-09 36.2 5.1 6.4 3 2 2 6 6 6 3 PHD-like zinc-binding domain PHD PF00628.29 EDO08237.1 - 7.9e-12 44.9 47.6 8.3e-06 25.6 3.9 5.7 5 0 0 5 5 5 4 PHD-finger PHD_2 PF13831.6 EDO08237.1 - 8.7e-09 34.8 2.2 8.7e-09 34.8 2.2 5.4 4 1 0 4 4 4 2 PHD-finger TERB2 PF15101.6 EDO08237.1 - 0.032 14.3 0.1 0.065 13.3 0.1 1.5 1 0 0 1 1 1 0 Telomere-associated protein TERB2 HAP2-GCS1 PF10699.9 EDO08238.1 - 4e-17 61.9 0.1 4e-17 61.9 0.1 2.6 3 0 0 3 3 3 1 Male gamete fusion factor Ras PF00071.22 EDO08239.1 - 1.5e-42 145.0 0.5 2.9e-40 137.5 0.5 2.1 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EDO08239.1 - 6.4e-30 103.8 0.4 3.7e-19 69.1 0.1 2.7 2 1 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO08239.1 - 2.9e-13 49.7 0.1 1.1e-10 41.3 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDO08239.1 - 6.8e-05 22.5 0.1 0.0001 21.9 0.1 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EDO08239.1 - 0.00025 21.0 0.5 0.15 11.9 0.1 2.3 2 0 0 2 2 2 2 RsgA GTPase ATP_bind_1 PF03029.17 EDO08239.1 - 0.00091 19.1 0.1 0.012 15.5 0.0 2.0 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 EDO08239.1 - 0.0019 18.3 0.0 0.0053 16.8 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EDO08239.1 - 0.034 14.2 0.4 0.28 11.2 0.4 2.1 1 1 0 1 1 1 0 Dynamin family Cyclin_N PF00134.23 EDO08242.1 - 1.8e-05 24.5 0.8 3.8e-05 23.4 0.2 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain Mab-21 PF03281.14 EDO08242.1 - 0.066 12.5 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Mab-21 protein DUF2009 PF09418.10 EDO08243.1 - 8.8e-191 634.9 1.6 1e-122 410.5 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2009) Ribosomal_L22e PF01776.17 EDO08243.1 - 0.1 13.0 0.2 0.26 11.7 0.2 1.7 1 0 0 1 1 1 0 Ribosomal L22e protein family Endopep_inhib PF16800.5 EDO08243.1 - 0.17 11.8 0.6 0.35 10.8 0.1 1.7 2 0 0 2 2 2 0 IseA DL-endopeptidase inhibitor CAF1 PF04857.20 EDO08244.1 - 1.1e-23 83.9 1.0 1e-11 44.6 0.0 2.4 1 1 1 2 2 2 2 CAF1 family ribonuclease RNase_H_2 PF13482.6 EDO08244.1 - 0.012 15.6 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 RNase_H superfamily DUF5118 PF17162.4 EDO08245.1 - 0.057 13.3 0.0 0.17 11.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5118) DUF647 PF04884.14 EDO08246.1 - 2.4e-24 86.3 5.7 4.5e-24 85.4 5.7 1.4 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis tRNA-synt_1 PF00133.22 EDO08247.1 - 4.2e-36 124.4 0.0 1.8e-12 46.3 0.0 4.0 3 1 0 3 3 3 3 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EDO08247.1 - 5.7e-16 58.8 0.0 1.1e-15 57.9 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EDO08247.1 - 8.1e-16 57.7 0.0 1.5e-07 30.5 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EDO08247.1 - 1.1e-08 34.9 0.0 3.4e-08 33.2 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 EDO08247.1 - 0.11 11.4 0.0 0.33 9.8 0.0 1.7 2 0 0 2 2 2 0 tRNA synthetases class I (K) Mito_carr PF00153.27 EDO08248.1 - 2.3e-32 110.8 4.8 9.5e-11 41.5 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Cullin PF00888.22 EDO08249.1 - 9.2e-43 146.8 9.4 9.9e-42 143.4 9.4 2.1 1 1 0 1 1 1 1 Cullin family FliMN_C PF01052.20 EDO08249.1 - 0.01 15.8 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 Type III flagellar switch regulator (C-ring) FliN C-term Cullin_Nedd8 PF10557.9 EDO08249.1 - 0.07 13.2 1.4 0.25 11.4 0.5 2.5 2 1 0 2 2 2 0 Cullin protein neddylation domain BLM10_mid PF16507.5 EDO08250.1 - 1.7e-48 165.6 0.3 4.1e-48 164.3 0.3 1.7 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 EDO08250.1 - 6.9e-24 83.6 0.2 2.9e-23 81.6 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3437) Fe-S_biosyn PF01521.20 EDO08251.1 - 5.1e-11 42.7 0.1 5.8e-11 42.6 0.1 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DUF4886 PF16227.5 EDO08251.1 - 0.044 13.0 0.0 0.053 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4886) VESA1_N PF12785.7 EDO08253.1 - 1.1e-18 67.4 2.8 1.1e-18 67.4 2.8 4.1 5 1 1 6 6 6 2 Variant erythrocyte surface antigen-1 SNF2_N PF00176.23 EDO08255.1 - 3.4e-47 160.8 0.2 6.2e-47 160.0 0.2 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain PHD PF00628.29 EDO08255.1 - 2e-19 69.2 72.8 3.9e-10 39.5 6.1 6.8 6 1 0 6 6 6 4 PHD-finger Helicase_C PF00271.31 EDO08255.1 - 1.9e-15 57.1 0.1 7.8e-15 55.2 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO08255.1 - 1.3e-07 31.8 0.0 4.7e-07 30.0 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-PHD-like PF15446.6 EDO08255.1 - 5.4e-06 26.1 47.0 0.0002 21.0 5.2 7.1 5 2 2 7 7 7 4 PHD/FYVE-zinc-finger like domain Prok-RING_1 PF14446.6 EDO08255.1 - 4e-05 23.4 12.3 5.9e-05 22.9 3.6 6.9 6 1 0 6 6 6 2 Prokaryotic RING finger family 1 DEAD PF00270.29 EDO08255.1 - 0.00025 20.9 0.0 0.00073 19.3 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase PHD_2 PF13831.6 EDO08255.1 - 0.00099 18.6 1.0 0.00099 18.6 1.0 7.6 8 0 0 8 8 8 1 PHD-finger C1_1 PF00130.22 EDO08255.1 - 0.0014 18.5 7.6 0.0051 16.7 1.6 8.2 6 2 2 8 8 8 3 Phorbol esters/diacylglycerol binding domain (C1 domain) AAA_14 PF13173.6 EDO08255.1 - 0.11 12.5 0.0 0.38 10.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 EDO08256.1 - 4.7e-30 104.6 0.0 7.6e-30 103.9 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDO08256.1 - 5e-05 23.4 0.0 0.00013 22.1 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDO08256.1 - 0.0005 20.0 0.5 0.86 9.5 0.0 3.0 3 1 0 3 3 3 2 RsgA GTPase AAA_22 PF13401.6 EDO08256.1 - 0.086 13.1 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.10 EDO08256.1 - 0.16 11.4 0.1 1.5 8.2 0.0 2.1 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Nop52 PF05997.12 EDO08257.1 - 2.4e-41 141.9 7.3 2.4e-41 141.9 7.3 1.8 2 0 0 2 2 2 1 Nucleolar protein,Nop52 DUF1090 PF06476.12 EDO08257.1 - 0.0058 16.7 2.8 0.78 9.9 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1090) NifU PF01106.17 EDO08258.1 - 4.2e-22 78.1 0.1 5.5e-22 77.7 0.1 1.2 1 0 0 1 1 1 1 NifU-like domain Ank_2 PF12796.7 EDO08259.1 - 7.7e-34 116.1 1.9 1.3e-06 28.9 0.0 5.9 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDO08259.1 - 7.6e-26 90.2 6.2 8.5e-07 29.4 0.0 7.7 4 2 4 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDO08259.1 - 6.2e-21 72.3 12.3 0.019 15.5 0.0 9.7 10 0 0 10 10 10 5 Ankyrin repeat Ank_5 PF13857.6 EDO08259.1 - 8.1e-21 73.8 3.6 9.7e-06 25.8 0.2 6.3 4 1 3 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 EDO08259.1 - 1.6e-17 63.1 9.6 0.26 11.8 0.2 9.0 8 1 1 9 9 9 6 Ankyrin repeat Kelch_4 PF13418.6 EDO08260.1 - 1.1e-34 118.2 9.3 6.7e-10 38.8 0.1 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 EDO08260.1 - 1.6e-25 88.8 12.9 2.6e-07 30.8 0.0 7.6 7 1 0 7 7 7 5 Galactose oxidase, central domain Kelch_6 PF13964.6 EDO08260.1 - 1.7e-25 88.4 9.5 3.4e-08 33.5 0.0 6.2 4 1 2 6 6 6 5 Kelch motif Kelch_5 PF13854.6 EDO08260.1 - 4.8e-24 83.9 11.6 1.4e-06 28.1 0.2 6.0 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 EDO08260.1 - 1.8e-11 43.4 15.9 0.00077 19.0 0.1 5.9 6 1 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 EDO08260.1 - 1.9e-08 34.0 13.2 0.085 12.9 0.0 6.1 6 0 0 6 6 6 4 Kelch motif PK PF00224.21 EDO08261.1 - 1.6e-137 458.0 2.3 2.1e-137 457.7 2.3 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 EDO08261.1 - 9.7e-23 80.6 2.1 2.1e-22 79.5 1.4 2.0 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain Crystall_2 PF09076.10 EDO08261.1 - 0.059 13.3 1.3 10 6.1 0.0 2.4 2 0 0 2 2 2 0 Beta/Gamma crystallin HTH_DeoR PF08220.12 EDO08261.1 - 0.17 11.7 0.0 0.4 10.5 0.0 1.6 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain adh_short PF00106.25 EDO08263.1 - 5.2e-29 101.1 0.0 7.3e-29 100.6 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDO08263.1 - 3.2e-18 66.2 0.0 2.4e-16 60.0 0.1 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EDO08263.1 - 9.1e-11 41.7 0.0 1.2e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EDO08263.1 - 1.6e-07 31.0 0.0 2.2e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase KR PF08659.10 EDO08263.1 - 7.5e-07 29.2 0.0 1.2e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 KR domain Pyr_redox_2 PF07992.14 EDO08263.1 - 0.014 14.7 0.1 0.02 14.2 0.1 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3Beta_HSD PF01073.19 EDO08263.1 - 0.05 12.6 0.0 0.067 12.2 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EDO08263.1 - 0.069 12.3 0.2 0.097 11.8 0.2 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein THF_DHG_CYH_C PF02882.19 EDO08263.1 - 0.1 11.9 0.1 0.23 10.8 0.1 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain RNase_PH PF01138.21 EDO08264.1 - 2.6e-05 24.7 0.0 8.6e-05 23.0 0.0 1.9 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EDO08264.1 - 0.045 13.8 0.0 0.089 12.8 0.0 1.5 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 La_HTH_kDCL PF18177.1 EDO08264.1 - 0.094 13.0 0.0 0.95 9.8 0.0 2.4 1 1 0 1 1 1 0 La HTH in kinetoplastid DICER domain AP2 PF00847.20 EDO08265.1 - 1.1e-06 28.7 3.7 2.5e-06 27.6 3.7 1.5 1 0 0 1 1 1 1 AP2 domain UCR_UQCRX_QCR9 PF05365.12 EDO08266.1 - 4.2e-12 45.8 0.0 1.4e-11 44.1 0.0 1.7 2 0 0 2 2 2 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like RAP PF08373.10 EDO08267.1 - 8.5e-12 45.0 0.3 3.4e-11 43.1 0.0 2.2 2 0 0 2 2 2 1 RAP domain FAST_1 PF06743.15 EDO08267.1 - 2.3e-05 24.2 0.3 0.11 12.5 0.1 3.8 3 0 0 3 3 3 2 FAST kinase-like protein, subdomain 1 GP3_package PF16677.5 EDO08267.1 - 0.11 12.6 0.1 0.29 11.3 0.1 1.7 1 0 0 1 1 1 0 DNA-packaging protein gp3 PIG-L PF02585.17 EDO08269.1 - 2.4e-17 63.8 0.0 3.3e-17 63.4 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase DUF4999 PF16390.5 EDO08269.1 - 0.058 13.6 0.1 0.25 11.6 0.0 2.1 3 0 0 3 3 3 0 Domain of unknown function Proteasome PF00227.26 EDO08270.1 - 4.7e-43 146.9 0.0 5.4e-43 146.7 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit VESA1_N PF12785.7 EDO08272.1 - 9.2e-19 67.7 2.8 9.2e-19 67.7 2.8 3.9 3 2 1 4 4 4 1 Variant erythrocyte surface antigen-1 Fe-S_biosyn PF01521.20 EDO08274.1 - 7.8e-11 42.2 0.1 8.9e-11 42.0 0.1 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DUF4886 PF16227.5 EDO08274.1 - 0.036 13.2 0.0 0.04 13.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4886) VESA1_N PF12785.7 EDO08275.1 - 1.5e-12 47.3 5.3 1.3e-07 31.0 0.0 5.2 5 1 0 5 5 5 2 Variant erythrocyte surface antigen-1 DUF4377 PF14302.6 EDO08275.1 - 0.13 12.4 0.1 0.37 10.9 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4377) Thioredoxin_7 PF13899.6 EDO08276.1 - 0.0016 18.6 0.3 0.0035 17.5 0.3 1.6 1 0 0 1 1 1 1 Thioredoxin-like Endonuc-BglII PF09195.11 EDO08276.1 - 0.033 14.0 1.7 0.059 13.2 0.9 1.9 2 0 0 2 2 2 0 Restriction endonuclease BglII DUF2570 PF10828.8 EDO08276.1 - 0.059 13.2 12.3 0.12 12.2 11.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2570) Troponin PF00992.20 EDO08276.1 - 0.089 13.1 13.8 0.059 13.7 11.2 1.9 1 1 1 2 2 2 0 Troponin DUF4477 PF14780.6 EDO08276.1 - 0.15 11.7 6.5 0.22 11.1 5.4 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4477) Thioredoxin PF00085.20 EDO08276.1 - 0.24 11.4 3.3 0.34 10.9 0.4 2.3 1 1 1 2 2 2 0 Thioredoxin FAP206 PF12018.8 EDO08276.1 - 0.28 10.6 10.0 0.48 9.9 10.0 1.3 1 0 0 1 1 1 0 Domain of unknown function SYCE1 PF15233.6 EDO08276.1 - 0.88 9.6 18.1 0.83 9.7 8.4 2.4 1 1 1 2 2 2 0 Synaptonemal complex central element protein 1 Atg14 PF10186.9 EDO08276.1 - 2.6 7.0 19.8 1.6 7.8 17.6 1.9 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 UPF0242 PF06785.11 EDO08276.1 - 2.7 8.1 20.1 1.6 8.8 6.6 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Syntaxin-6_N PF09177.11 EDO08276.1 - 6 7.5 12.6 13 6.4 9.8 2.9 2 1 0 2 2 2 0 Syntaxin 6, N-terminal SlyX PF04102.12 EDO08276.1 - 7.1 7.3 18.1 0.8 10.4 9.0 2.9 1 1 2 3 3 3 0 SlyX Sec2p PF06428.11 EDO08276.1 - 8 6.5 15.4 14 5.7 3.1 3.3 1 1 2 3 3 3 0 GDP/GTP exchange factor Sec2p AAA PF00004.29 EDO08277.1 - 2.7e-08 34.3 0.3 1.5e-07 31.9 0.0 2.5 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EDO08277.1 - 3.6e-07 30.3 0.1 2.2e-06 27.8 0.1 2.3 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_18 PF13238.6 EDO08277.1 - 9.3e-06 26.2 0.1 6.7e-05 23.4 0.1 2.5 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EDO08277.1 - 0.00019 21.4 0.0 0.0005 20.0 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase dNK PF01712.19 EDO08277.1 - 0.0002 21.3 0.9 0.039 13.8 0.0 2.6 2 0 0 2 2 2 1 Deoxynucleoside kinase AAA_16 PF13191.6 EDO08277.1 - 0.00027 21.4 0.1 0.0013 19.1 0.0 2.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EDO08277.1 - 0.00081 19.7 0.5 0.019 15.3 0.5 2.9 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EDO08277.1 - 0.0013 18.7 0.0 0.0044 17.0 0.0 2.0 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 EDO08277.1 - 0.0013 18.0 0.0 0.0028 17.0 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_14 PF13173.6 EDO08277.1 - 0.012 15.6 0.0 0.036 14.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 EDO08277.1 - 0.015 15.0 0.3 0.25 11.0 0.0 2.3 2 0 0 2 2 2 0 Cytidylate kinase AAA_6 PF12774.7 EDO08277.1 - 0.02 13.9 0.0 0.057 12.4 0.0 1.7 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region DsrC PF04358.13 EDO08277.1 - 0.02 15.4 0.1 0.084 13.4 0.0 2.1 2 0 0 2 2 1 0 DsrC like protein ABC_tran PF00005.27 EDO08277.1 - 0.035 14.6 0.0 0.17 12.4 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_33 PF13671.6 EDO08277.1 - 0.042 14.0 0.1 0.15 12.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain LexA_DNA_bind PF01726.16 EDO08277.1 - 0.11 12.3 0.1 2 8.3 0.0 2.7 2 0 0 2 2 2 0 LexA DNA binding domain AAA_17 PF13207.6 EDO08277.1 - 0.35 11.3 0.0 0.35 11.3 0.0 2.2 3 0 0 3 3 1 0 AAA domain PIN_12 PF16289.5 EDO08277.1 - 4.2 7.8 6.2 45 4.5 0.6 3.4 3 0 0 3 3 3 0 PIN domain PAP2_C PF14360.6 EDO08278.1 - 2.2e-16 60.1 10.3 2.2e-16 60.1 10.3 2.4 3 0 0 3 3 3 1 PAP2 superfamily C-terminal PAP2 PF01569.21 EDO08278.1 - 9.8e-06 25.4 5.5 9.8e-06 25.4 5.5 1.9 2 1 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EDO08278.1 - 0.00027 20.7 9.9 0.00027 20.7 9.9 1.9 2 1 0 2 2 2 1 PAP2 superfamily Ly49 PF08391.10 EDO08278.1 - 9.4 6.6 8.9 20 5.6 1.9 2.5 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region Mito_carr PF00153.27 EDO08279.1 - 2.4e-06 27.4 0.1 0.073 13.0 0.0 2.5 2 0 0 2 2 2 2 Mitochondrial carrier protein PA14 PF07691.12 EDO08281.1 - 9.4e-17 61.2 0.0 6e-16 58.6 0.0 2.3 2 1 1 3 3 3 1 PA14 domain fn2 PF00040.19 EDO08281.1 - 0.00018 21.7 1.0 0.0004 20.6 1.0 1.7 1 0 0 1 1 1 1 Fibronectin type II domain NUDIX_2 PF13869.6 EDO08282.1 - 2.9e-60 203.1 0.0 4.6e-60 202.4 0.0 1.3 1 0 0 1 1 1 1 Nucleotide hydrolase PRY PF13765.6 EDO08282.1 - 0.099 12.3 0.0 0.32 10.6 0.0 1.8 1 0 0 1 1 1 0 SPRY-associated domain Acetyltransf_1 PF00583.25 EDO08284.1 - 1.8e-13 50.7 0.1 2.3e-13 50.4 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDO08284.1 - 6.1e-09 35.9 0.0 7.4e-09 35.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDO08284.1 - 4.7e-07 30.2 0.0 6.3e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDO08284.1 - 1.4e-05 25.0 0.0 2.1e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 EDO08284.1 - 0.00041 21.1 0.0 0.00047 20.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EDO08284.1 - 0.055 13.6 0.0 0.11 12.6 0.0 1.5 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain tRNA-synt_2d PF01409.20 EDO08285.1 - 3.5e-57 193.7 0.0 4.7e-57 193.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.25 EDO08285.1 - 0.00098 19.1 0.0 0.0021 18.1 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2 PF00152.20 EDO08285.1 - 0.0013 17.9 0.1 0.0061 15.7 0.0 2.0 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) PheRS_DBD3 PF18553.1 EDO08285.1 - 0.0031 17.7 0.0 0.011 16.0 0.0 1.9 2 0 0 2 2 2 1 PheRS DNA binding domain 3 PheRS_DBD1 PF18552.1 EDO08285.1 - 0.0077 16.0 0.0 0.17 11.7 0.0 2.6 2 0 0 2 2 2 1 PheRS DNA binding domain 1 tRNA_synthFbeta PF17759.1 EDO08285.1 - 0.034 13.6 0.0 0.65 9.4 0.0 2.2 2 0 0 2 2 2 0 Phenylalanyl tRNA synthetase beta chain CLM domain Mre11_DNA_bind PF04152.14 EDO08286.1 - 3.2e-33 115.4 0.0 6.8e-33 114.4 0.0 1.5 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 EDO08286.1 - 6.6e-14 52.9 0.3 1.4e-13 51.8 0.3 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EDO08286.1 - 1.2e-05 25.5 0.0 0.00026 21.2 0.0 2.9 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain Iso_dh PF00180.20 EDO08287.1 - 4e-64 217.0 0.0 4.7e-64 216.7 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Phe_ZIP PF08916.11 EDO08287.1 - 0.1 13.3 0.1 0.22 12.3 0.1 1.5 1 0 0 1 1 1 0 Phenylalanine zipper DUF981 PF06168.11 EDO08288.1 - 0.18 11.7 4.4 0.25 11.2 4.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF981) Fe-S_biosyn PF01521.20 EDO08290.1 - 7.4e-11 42.2 0.0 1.1e-10 41.7 0.0 1.2 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis D123 PF07065.14 EDO08291.1 - 2.8e-24 85.8 0.7 1e-22 80.7 0.7 2.1 1 1 0 1 1 1 1 D123 Sec1 PF00995.23 EDO08292.1 - 6e-61 207.4 0.0 8.5e-61 206.9 0.0 1.1 1 0 0 1 1 1 1 Sec1 family OTU PF02338.19 EDO08293.1 - 1.1e-06 29.2 0.0 2e-05 25.1 0.0 2.2 1 1 0 1 1 1 1 OTU-like cysteine protease GATA PF00320.27 EDO08295.1 - 1.7e-06 27.5 4.1 4e-06 26.3 4.1 1.7 1 0 0 1 1 1 1 GATA zinc finger zf-RING_7 PF02591.15 EDO08295.1 - 0.013 15.7 0.7 0.031 14.5 0.7 1.7 1 0 0 1 1 1 0 C4-type zinc ribbon domain CCDC158 PF15921.5 EDO08295.1 - 0.16 9.7 0.1 0.21 9.4 0.1 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 158 SRR PF07709.11 EDO08296.1 - 0.082 13.3 0.0 6.1 7.7 0.0 2.8 3 0 0 3 3 3 0 Seven Residue Repeat Ras PF00071.22 EDO08297.1 - 1.3e-59 200.4 0.0 1.6e-59 200.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO08297.1 - 1.9e-34 118.5 0.0 2.5e-34 118.1 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO08297.1 - 9.8e-16 57.7 0.0 1.3e-15 57.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDO08297.1 - 1.3e-05 24.7 0.0 1.5e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDO08297.1 - 4e-05 23.7 0.0 6e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDO08297.1 - 0.00024 20.7 0.0 0.00057 19.5 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EDO08297.1 - 0.00081 19.3 0.0 0.37 10.7 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 EDO08297.1 - 0.0016 17.9 0.0 0.0021 17.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 EDO08297.1 - 0.026 14.8 0.0 0.092 13.0 0.0 2.0 1 1 1 2 2 2 0 AAA domain AAA_16 PF13191.6 EDO08297.1 - 0.056 13.8 0.1 0.095 13.1 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain CENP-M PF11111.8 EDO08297.1 - 0.15 11.3 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 Centromere protein M (CENP-M) G-alpha PF00503.20 EDO08297.1 - 0.17 11.0 0.4 2 7.5 0.1 2.1 1 1 1 2 2 2 0 G-protein alpha subunit Pkinase PF00069.25 EDO08298.1 - 2.5e-36 125.4 0.0 1.2e-20 74.0 0.0 2.4 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO08298.1 - 4.1e-09 36.1 0.0 0.0032 16.8 0.0 3.0 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDO08298.1 - 0.17 10.6 0.0 0.24 10.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase HSP90 PF00183.18 EDO08299.1 - 4.3e-145 484.6 11.4 1e-143 480.0 11.4 2.0 1 1 0 1 1 1 1 Hsp90 protein HATPase_c_3 PF13589.6 EDO08299.1 - 1.9e-11 43.9 0.1 3.9e-11 42.9 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EDO08299.1 - 1.3e-10 41.8 0.1 3.2e-10 40.5 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Caprin-1_dimer PF18293.1 EDO08300.1 - 0.098 13.1 0.1 1.1 9.8 0.0 2.2 2 0 0 2 2 2 0 Caprin-1 dimerization domain RNA_pol_Rpb1_5 PF04998.17 EDO08301.1 - 4e-85 285.5 0.4 5.8e-85 285.0 0.4 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 EDO08301.1 - 6.7e-76 255.6 1.7 1.1e-75 254.9 1.7 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 EDO08301.1 - 1.7e-70 236.6 0.0 3.5e-70 235.5 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EDO08301.1 - 1.5e-32 112.7 0.0 5.4e-32 110.9 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EDO08301.1 - 8.7e-29 99.6 0.0 2.4e-28 98.2 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 DUF4953 PF16313.5 EDO08301.1 - 0.087 12.0 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Met-zincin Gpi16 PF04113.14 EDO08303.1 - 4.9e-17 61.6 0.1 3.9e-09 35.5 0.0 2.4 2 1 0 2 2 2 2 Gpi16 subunit, GPI transamidase component Ldh_2 PF02615.14 EDO08303.1 - 0.18 10.9 0.0 0.28 10.3 0.0 1.2 1 0 0 1 1 1 0 Malate/L-lactate dehydrogenase Ribosomal_S15 PF00312.22 EDO08304.1 - 4.6e-22 78.0 0.2 1.1e-21 76.9 0.2 1.7 1 0 0 1 1 1 1 Ribosomal protein S15 LETM1 PF07766.13 EDO08304.1 - 0.004 16.5 0.7 0.0077 15.6 0.7 1.4 1 0 0 1 1 1 1 LETM1-like protein TAL_FSA PF00923.19 EDO08305.1 - 0.065 12.6 0.2 0.12 11.7 0.2 1.4 1 0 0 1 1 1 0 Transaldolase/Fructose-6-phosphate aldolase ABC_ATPase PF09818.9 EDO08308.1 - 4.8e-161 536.5 0.0 1.1e-158 528.8 0.0 2.1 1 1 1 2 2 2 2 Predicted ATPase of the ABC class AAA_23 PF13476.6 EDO08308.1 - 1e-05 26.1 0.2 2.4e-05 25.0 0.2 1.5 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EDO08308.1 - 0.11 12.0 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Helicase_C PF00271.31 EDO08311.1 - 6.2e-14 52.3 0.0 1.5e-13 51.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDO08312.1 - 5.5e-13 49.1 0.0 7.4e-13 48.6 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase EF-hand_7 PF13499.6 EDO08313.1 - 2e-21 76.2 11.9 2.9e-09 37.2 0.1 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 EDO08313.1 - 2.1e-21 74.4 13.6 0.00028 20.3 0.2 5.5 5 0 0 5 5 5 5 EF hand EF-hand_1 PF00036.32 EDO08313.1 - 3.8e-21 73.0 17.1 0.00022 20.5 0.6 5.9 6 0 0 6 6 6 5 EF hand EF-hand_6 PF13405.6 EDO08313.1 - 2.6e-20 70.5 12.7 0.00079 19.2 0.1 5.8 6 0 0 6 6 6 5 EF-hand domain EF-hand_8 PF13833.6 EDO08313.1 - 1.1e-05 25.1 18.0 0.88 9.5 0.0 5.6 5 1 1 6 6 6 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EDO08313.1 - 0.00099 19.4 5.7 2 8.7 1.3 4.4 2 2 2 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region REGB_T4 PF10715.9 EDO08313.1 - 0.0028 17.9 1.2 0.33 11.1 0.1 2.2 1 1 1 2 2 2 2 T4-page Endoribonuclease RegB Dockerin_1 PF00404.18 EDO08313.1 - 0.031 14.4 5.7 3.3 8.0 0.2 4.6 3 2 1 4 4 4 0 Dockerin type I domain EF-hand_4 PF12763.7 EDO08313.1 - 0.36 10.8 3.3 0.78 9.7 0.2 2.7 3 1 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand Ribosomal_S4e PF00900.20 EDO08314.1 - 1.1e-31 108.5 0.2 3.4e-31 107.0 0.0 1.8 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.5 EDO08314.1 - 7.8e-21 73.5 0.0 1.4e-20 72.6 0.0 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 EDO08314.1 - 3.8e-19 68.5 6.8 7.8e-19 67.5 6.8 1.6 1 0 0 1 1 1 1 RS4NT (NUC023) domain KOW PF00467.29 EDO08314.1 - 1.3e-06 28.2 4.0 2.1e-06 27.5 1.0 2.8 3 0 0 3 3 3 1 KOW motif S4 PF01479.25 EDO08314.1 - 0.00031 20.4 0.0 0.00058 19.5 0.0 1.5 1 0 0 1 1 1 1 S4 domain Sipho_tail PF05709.11 EDO08314.1 - 0.0048 16.3 0.0 0.0061 16.0 0.0 1.2 1 0 0 1 1 1 1 Phage tail protein EF-hand_6 PF13405.6 EDO08315.1 - 5.2e-11 41.6 0.5 1.9e-07 30.5 0.1 3.8 4 0 0 4 4 4 1 EF-hand domain EF-hand_7 PF13499.6 EDO08315.1 - 7.2e-11 42.4 0.4 1.4e-08 35.1 0.4 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EDO08315.1 - 9.2e-09 34.2 0.3 4.2e-06 25.9 0.1 3.2 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.6 EDO08315.1 - 3.5e-05 23.6 2.1 0.002 18.0 0.3 3.1 1 1 1 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 EDO08315.1 - 0.00057 19.3 0.1 0.0015 18.0 0.1 1.8 1 0 0 1 1 1 1 EF hand Caleosin PF05042.13 EDO08315.1 - 0.0061 16.5 0.1 0.016 15.1 0.1 1.7 1 1 0 1 1 1 1 Caleosin related protein MliC PF09864.9 EDO08315.1 - 0.15 12.0 0.0 0.34 10.9 0.0 1.6 1 0 0 1 1 1 0 Membrane-bound lysozyme-inhibitor of c-type lysozyme Pkinase PF00069.25 EDO08316.1 - 2e-46 158.5 0.0 2.7e-46 158.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO08316.1 - 4.4e-17 62.2 0.0 6.8e-17 61.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDO08316.1 - 3.1e-09 36.1 0.0 5.3e-09 35.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EDO08316.1 - 1.3e-08 34.5 0.0 2.1e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDO08316.1 - 0.0017 18.3 0.0 0.013 15.5 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EDO08316.1 - 0.0063 15.9 0.0 0.65 9.3 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Pox_ser-thr_kin PF05445.11 EDO08316.1 - 0.088 11.8 0.1 0.13 11.2 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase CENP-T_C PF15511.6 EDO08317.1 - 9.1e-09 35.4 0.1 1.1e-08 35.2 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 EDO08317.1 - 0.0005 20.2 0.0 0.00068 19.8 0.0 1.3 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 EDO08317.1 - 0.00083 19.7 0.1 0.0011 19.3 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EDO08317.1 - 0.0016 18.7 0.0 0.0023 18.2 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDO08317.1 - 0.0075 16.6 0.1 0.0083 16.5 0.1 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 EDO08317.1 - 0.042 13.9 0.0 0.048 13.7 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EDO08317.1 - 0.058 13.4 0.0 0.08 13.0 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 EDO08317.1 - 0.086 12.6 0.1 0.11 12.3 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) EF-hand_7 PF13499.6 EDO08318.1 - 3.6e-06 27.3 0.2 0.00028 21.3 0.1 2.9 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 EDO08318.1 - 1.6e-05 24.4 0.1 0.00041 20.0 0.0 2.8 2 0 0 2 2 2 1 EF-hand domain RAP PF08373.10 EDO08318.1 - 0.00015 21.7 0.2 0.00048 20.2 0.2 1.8 1 0 0 1 1 1 1 RAP domain EF-hand_8 PF13833.6 EDO08318.1 - 0.00047 20.0 0.0 0.003 17.4 0.0 2.4 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 EDO08318.1 - 0.00051 19.4 0.0 0.0013 18.1 0.0 1.8 1 0 0 1 1 1 1 EF hand zf-rbx1 PF12678.7 EDO08319.1 - 9.5e-25 86.7 13.6 1.4e-24 86.1 13.6 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EDO08319.1 - 1.7e-16 60.0 11.3 3.3e-16 59.1 11.3 1.4 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EDO08319.1 - 2e-05 24.8 16.4 0.0015 18.9 16.4 2.3 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDO08319.1 - 0.00041 20.1 3.5 0.00041 20.1 3.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EDO08319.1 - 0.0012 18.6 1.5 0.0012 18.6 1.5 2.5 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 EDO08319.1 - 0.014 15.3 14.1 0.34 10.8 14.1 2.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Toxin_18 PF08087.11 EDO08319.1 - 0.019 14.9 0.9 0.039 13.9 0.9 1.7 1 0 0 1 1 1 0 Conotoxin O-superfamily zf-RING_UBOX PF13445.6 EDO08319.1 - 0.38 10.8 9.7 2 8.5 9.7 2.2 1 1 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 EDO08319.1 - 1 9.4 14.5 10 6.2 14.6 2.6 1 1 1 2 2 2 0 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EDO08319.1 - 1.4 8.6 16.6 0.31 10.7 6.5 2.4 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 EDO08319.1 - 1.9 8.7 13.0 12 6.2 13.0 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_3 PF13920.6 EDO08319.1 - 2.7 7.9 13.0 11 6.0 0.3 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDO08319.1 - 3.8 7.8 10.2 0.46 10.7 0.6 2.7 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING ANAPC4_WD40 PF12894.7 EDO08320.1 - 7.3e-07 29.4 0.0 0.21 11.9 0.0 4.0 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO08320.1 - 0.01 16.7 6.3 28 5.8 0.1 4.9 3 1 1 4 4 4 0 WD domain, G-beta repeat PD40 PF07676.12 EDO08320.1 - 0.088 12.8 2.6 13 5.9 0.0 3.8 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat PhoLip_ATPase_C PF16212.5 EDO08321.1 - 4.7e-66 223.1 26.1 4.7e-66 223.1 26.1 3.1 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EDO08321.1 - 4.1e-13 48.8 0.1 1.3e-12 47.3 0.1 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EDO08321.1 - 4.2e-07 29.7 2.9 1.5e-06 27.9 0.0 3.3 3 1 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EDO08321.1 - 2.4e-05 24.7 0.3 0.083 13.2 0.0 3.2 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDO08321.1 - 0.00021 21.3 0.0 0.00096 19.2 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EDO08321.1 - 0.061 13.1 0.1 0.16 11.7 0.1 1.7 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF1682 PF07946.14 EDO08322.1 - 1.5e-39 136.1 5.0 2.4e-39 135.4 5.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) HCNGP PF07818.13 EDO08323.1 - 1e-16 61.3 1.8 1.4e-16 60.9 1.8 1.3 1 1 0 1 1 1 1 HCNGP-like protein WH1 PF00568.23 EDO08324.1 - 0.015 15.2 0.1 0.05 13.5 0.0 1.9 3 0 0 3 3 3 0 WH1 domain WD40 PF00400.32 EDO08325.1 - 4.5e-42 141.2 22.3 9.5e-07 29.4 2.4 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.8 EDO08325.1 - 2.7e-06 26.3 3.5 0.0044 15.7 0.0 3.8 2 2 2 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EDO08325.1 - 1.6e-05 25.1 2.3 2.3 8.6 0.1 4.8 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 EDO08325.1 - 0.0051 15.6 1.2 4.8 5.8 0.1 3.5 1 1 3 4 4 4 2 Nup133 N terminal like WD40_like PF17005.5 EDO08325.1 - 0.014 14.7 0.0 10 5.4 0.0 3.0 1 1 2 3 3 3 0 WD40-like domain Hira PF07569.11 EDO08325.1 - 0.7 9.6 3.5 7.3 6.2 0.1 3.4 3 1 1 4 4 4 0 TUP1-like enhancer of split FAT PF02259.23 EDO08326.1 - 6.4e-21 74.9 0.4 8.5e-20 71.2 0.1 2.4 2 0 0 2 2 2 1 FAT domain DUF4060 PF13269.6 EDO08326.1 - 0.17 12.0 0.2 0.58 10.3 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF4060) DUF5359 PF17313.2 EDO08326.1 - 0.2 11.7 2.3 21 5.2 0.0 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF5359) Peptidase_C2 PF00648.21 EDO08327.1 - 5.7e-32 110.9 0.0 1e-30 106.8 0.0 2.1 1 1 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 EDO08327.1 - 1.3e-13 51.4 0.1 8.1e-06 26.2 0.0 3.3 3 0 0 3 3 3 3 Calpain large subunit, domain III TIP49 PF06068.13 EDO08328.1 - 2.5e-147 490.7 0.1 3e-147 490.4 0.1 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EDO08328.1 - 4.9e-18 65.0 0.1 1.4e-17 63.6 0.1 1.8 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 EDO08328.1 - 5.3e-10 39.8 1.3 1.6e-06 28.6 0.2 3.4 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EDO08328.1 - 1.9e-07 30.9 1.0 2e-05 24.4 0.0 2.9 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDO08328.1 - 2.4e-07 31.3 0.1 8e-07 29.6 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EDO08328.1 - 1.4e-05 25.4 0.2 0.15 12.3 0.1 2.8 2 1 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 EDO08328.1 - 9.7e-05 22.1 0.1 0.035 13.8 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_5 PF07728.14 EDO08328.1 - 0.00012 22.0 0.1 0.0096 15.9 0.0 3.0 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 EDO08328.1 - 0.00013 22.4 0.1 0.00023 21.7 0.1 1.4 1 0 0 1 1 1 1 ABC transporter AAA_33 PF13671.6 EDO08328.1 - 0.00041 20.5 0.0 0.0012 19.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EDO08328.1 - 0.00074 20.0 0.1 0.0019 18.6 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_25 PF13481.6 EDO08328.1 - 0.00074 19.1 0.0 0.0015 18.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 EDO08328.1 - 0.0014 18.0 0.0 0.0021 17.4 0.0 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain Mg_chelatase PF01078.21 EDO08328.1 - 0.0017 17.8 0.3 0.011 15.1 0.1 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EDO08328.1 - 0.0048 16.6 0.0 0.0093 15.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein NACHT PF05729.12 EDO08328.1 - 0.005 16.8 0.0 0.0083 16.0 0.0 1.4 1 0 0 1 1 1 1 NACHT domain T2SSE PF00437.20 EDO08328.1 - 0.012 14.7 0.0 0.022 13.8 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ResIII PF04851.15 EDO08328.1 - 0.012 15.6 0.1 0.037 14.0 0.1 1.8 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_18 PF13238.6 EDO08328.1 - 0.014 15.9 0.0 0.039 14.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 EDO08328.1 - 0.015 15.3 0.0 0.032 14.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 EDO08328.1 - 0.016 14.5 0.1 0.03 13.6 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin PhoH PF02562.16 EDO08328.1 - 0.019 14.5 0.1 0.056 12.9 0.1 1.7 1 0 0 1 1 1 0 PhoH-like protein AAA_32 PF13654.6 EDO08328.1 - 0.026 13.3 0.0 0.049 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDO08328.1 - 0.031 14.7 0.0 0.086 13.2 0.0 1.8 1 0 0 1 1 1 0 RNA helicase DNA_pol3_delta2 PF13177.6 EDO08328.1 - 0.032 14.0 0.1 0.23 11.2 0.1 2.3 1 1 0 1 1 1 0 DNA polymerase III, delta subunit AAA_19 PF13245.6 EDO08328.1 - 0.033 14.5 0.7 0.21 11.9 0.7 2.1 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EDO08328.1 - 0.035 14.1 0.0 1.2 9.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EDO08328.1 - 0.047 13.4 0.1 0.096 12.4 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.6 EDO08328.1 - 0.053 13.2 0.6 0.39 10.4 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_2 PF07724.14 EDO08328.1 - 0.076 13.1 0.1 0.32 11.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_7 PF12775.7 EDO08328.1 - 0.082 12.4 0.0 0.21 11.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region APS_kinase PF01583.20 EDO08328.1 - 0.12 12.3 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase VESA1_N PF12785.7 EDO08329.1 - 1.1e-219 730.1 23.3 1.1e-219 730.1 23.3 2.7 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 ALIX_LYPXL_bnd PF13949.6 EDO08329.1 - 0.053 12.8 0.4 0.14 11.4 0.4 1.6 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV Nup54 PF13874.6 EDO08329.1 - 0.075 13.1 1.0 0.62 10.2 0.0 2.3 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 COG2 PF06148.11 EDO08329.1 - 0.34 11.0 4.6 2 8.5 0.4 2.6 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Rx_N PF18052.1 EDO08329.1 - 1.5 9.2 3.7 42 4.5 0.0 3.2 3 0 0 3 3 3 0 Rx N-terminal domain TPR_MLP1_2 PF07926.12 EDO08329.1 - 7.3 6.7 8.0 7.3 6.7 1.6 2.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein VESA1_N PF12785.7 EDO08330.1 - 2.9e-23 82.6 29.0 9.9e-13 47.9 0.1 4.0 2 1 1 3 3 3 3 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO08332.1 - 6e-226 750.7 21.2 6e-226 750.7 21.2 2.7 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 VESA1_N PF12785.7 EDO08333.1 - 1.8e-222 739.2 18.7 1.8e-222 739.2 18.7 2.4 2 0 0 2 2 2 1 Variant erythrocyte surface antigen-1 DUF937 PF06078.11 EDO08333.1 - 0.38 11.3 9.2 0.094 13.3 3.9 2.9 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF937) F-box-like_2 PF13013.6 EDO08334.1 - 2.8e-08 33.7 0.5 1e-05 25.4 0.1 2.2 1 1 1 2 2 2 2 F-box-like domain TatD_DNase PF01026.21 EDO08335.1 - 0.051 13.0 0.0 0.051 13.0 0.0 1.0 1 0 0 1 1 1 0 TatD related DNase Acetyltransf_4 PF13420.7 EDO08336.1 - 0.022 14.9 1.2 1.1 9.4 0.0 2.6 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain Phage_ABA_S PF18066.1 EDO08336.1 - 0.1 13.3 0.3 0.44 11.3 0.2 2.1 1 1 0 1 1 1 0 Phage ABA sandwich domain RtcB PF01139.17 EDO08337.1 - 2.1e-121 406.0 0.1 2.5e-121 405.7 0.1 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB CoA_binding PF02629.19 EDO08338.1 - 9.7e-24 83.9 0.4 2.7e-23 82.5 0.1 1.9 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 EDO08338.1 - 1.9e-23 83.0 0.2 3.1e-23 82.3 0.2 1.4 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 EDO08338.1 - 4.6e-11 42.7 0.0 7.4e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 EDO08338.1 - 0.015 15.7 0.0 0.038 14.5 0.0 1.7 2 0 0 2 2 2 0 CoA binding domain Pkinase PF00069.25 EDO08339.1 - 1.7e-65 221.0 0.2 2.1e-65 220.7 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO08339.1 - 3.5e-23 82.2 0.0 4.9e-23 81.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDO08339.1 - 2e-08 34.5 0.0 3.7e-06 27.0 0.0 2.2 1 1 0 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EDO08339.1 - 0.014 14.7 0.2 0.026 13.9 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EDO08339.1 - 0.017 13.9 0.0 0.037 12.8 0.0 1.4 2 0 0 2 2 2 0 Fungal protein kinase Choline_kinase PF01633.20 EDO08339.1 - 0.032 13.8 0.1 0.072 12.7 0.1 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kinase-like PF14531.6 EDO08339.1 - 0.035 13.4 0.0 0.11 11.7 0.0 1.7 2 0 0 2 2 2 0 Kinase-like HSP70 PF00012.20 EDO08340.1 - 1.8e-241 802.5 13.9 2.1e-241 802.4 13.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDO08340.1 - 2.6e-20 72.5 4.8 9.9e-20 70.6 2.6 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 EDO08340.1 - 0.0025 18.2 13.4 0.02 15.3 0.5 4.0 3 3 0 3 3 3 2 Cell division protein FtsA Radial_spoke_3 PF06098.11 EDO08340.1 - 0.0064 15.8 3.5 0.016 14.5 3.5 1.6 1 0 0 1 1 1 1 Radial spoke protein 3 HMG-CoA_red PF00368.18 EDO08340.1 - 0.04 12.9 0.5 0.12 11.4 0.1 1.9 2 1 0 2 2 2 0 Hydroxymethylglutaryl-coenzyme A reductase Carb_kinase PF01256.17 EDO08340.1 - 0.058 12.9 0.4 0.22 11.0 0.2 1.9 2 0 0 2 2 2 0 Carbohydrate kinase DUF86 PF01934.17 EDO08340.1 - 1.2 9.0 4.2 7.8 6.4 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function DUF86 SesA PF17107.5 EDO08340.1 - 1.7 8.9 6.6 1 9.5 0.4 2.7 2 1 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases RNR_N PF08343.10 EDO08340.1 - 5.1 7.2 5.5 1.9 8.6 0.2 2.7 2 0 0 2 2 2 0 Ribonucleotide reductase N-terminal DUF1712 PF08217.11 EDO08341.1 - 8.7e-11 41.0 8.5 1.3e-07 30.6 4.0 2.4 2 1 0 2 2 2 2 Fungal domain of unknown function (DUF1712) TPR_1 PF00515.28 EDO08342.1 - 4.8e-07 29.3 7.3 4.9e-05 23.0 0.1 4.2 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EDO08342.1 - 9.2e-05 22.1 7.6 0.035 13.8 5.9 3.3 2 1 0 2 2 2 2 TPR repeat TPR_17 PF13431.6 EDO08342.1 - 0.00014 22.0 2.5 0.52 10.8 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDO08342.1 - 0.0003 20.7 5.3 0.0058 16.7 0.0 3.6 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDO08342.1 - 0.006 17.2 0.7 0.53 11.0 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDO08342.1 - 0.0072 17.1 0.6 0.66 10.9 0.0 3.7 2 1 2 4 4 4 1 Tetratricopeptide repeat DUF357 PF04010.13 EDO08342.1 - 0.0078 16.3 1.2 3.8 7.7 0.0 3.0 2 1 1 3 3 3 2 Protein of unknown function (DUF357) IQ_SEC7_PH PF16453.5 EDO08342.1 - 0.031 14.2 1.2 1.4 8.9 0.3 2.9 2 1 0 2 2 2 0 PH domain DUF2118 PF09891.9 EDO08342.1 - 0.037 14.0 1.4 0.061 13.3 0.1 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2118) ATPgrasp_Ter PF15632.6 EDO08342.1 - 0.11 12.2 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon L27 PF02828.16 EDO08342.1 - 0.13 12.1 0.4 0.3 10.9 0.1 1.8 2 0 0 2 2 2 0 L27 domain TPR_8 PF13181.6 EDO08342.1 - 1.4 9.4 8.9 5.1 7.6 0.0 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat PRP38 PF03371.15 EDO08343.1 - 0.027 14.4 0.0 0.029 14.2 0.0 1.1 1 0 0 1 1 1 0 PRP38 family DnaJ PF00226.31 EDO08344.1 - 1.1e-22 79.9 2.0 1.9e-22 79.1 2.0 1.4 1 0 0 1 1 1 1 DnaJ domain Thioredoxin PF00085.20 EDO08344.1 - 1.5e-13 50.6 0.8 1.2e-12 47.7 0.2 2.2 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_6 PF13848.6 EDO08344.1 - 5.9e-05 23.1 0.1 5.9e-05 23.1 0.1 1.6 2 0 0 2 2 2 1 Thioredoxin-like domain TraF PF13728.6 EDO08344.1 - 0.00075 19.4 0.1 0.0013 18.6 0.1 1.3 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 EDO08344.1 - 0.0016 18.4 0.3 0.0045 17.0 0.1 1.9 2 0 0 2 2 2 1 Thioredoxin domain Glutaredoxin PF00462.24 EDO08344.1 - 0.0055 16.9 0.7 0.022 15.0 0.3 2.2 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin_2 PF13098.6 EDO08344.1 - 0.022 15.2 1.4 0.8 10.2 0.7 3.3 2 1 0 2 2 2 0 Thioredoxin-like domain AhpC-TSA PF00578.21 EDO08344.1 - 0.17 11.8 1.2 1.4 8.9 0.1 2.6 3 0 0 3 3 3 0 AhpC/TSA family Acetyltransf_1 PF00583.25 EDO08345.1 - 4.5e-10 39.8 0.0 9.2e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDO08345.1 - 3.2e-06 27.5 0.0 6.2e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EDO08345.1 - 0.00017 21.6 0.0 0.00027 20.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EDO08345.1 - 0.00028 21.0 0.1 0.0006 20.0 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EDO08345.1 - 0.045 14.4 0.0 0.085 13.5 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain GTP_cyclohydro2 PF00925.20 EDO08345.1 - 0.11 12.1 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 GTP cyclohydrolase II His_Phos_1 PF00300.22 EDO08346.1 - 5.7e-36 124.0 0.0 2.6e-26 92.5 0.0 2.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Exc PF07825.11 EDO08346.1 - 0.12 12.4 0.1 0.24 11.4 0.1 1.5 1 0 0 1 1 1 0 Excisionase-like protein Abhydrolase_1 PF00561.20 EDO08347.1 - 1.8e-08 34.4 0.0 0.00026 20.7 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDO08347.1 - 5.9e-08 32.3 0.0 0.00042 19.7 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EDO08347.1 - 1e-05 26.2 0.0 5.8e-05 23.8 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 EDO08347.1 - 0.0028 17.5 0.0 0.0039 17.1 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase FSH1 PF03959.13 EDO08347.1 - 0.029 14.0 0.0 0.061 13.0 0.0 1.5 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 EDO08347.1 - 0.051 13.1 0.0 0.2 11.1 0.0 2.1 2 1 0 2 2 2 0 Prolyl oligopeptidase family DUF818 PF05677.12 EDO08347.1 - 0.25 10.3 0.2 0.36 9.7 0.2 1.1 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) AP2 PF00847.20 EDO08348.1 - 0.19 12.0 0.1 0.19 12.0 0.1 5.4 7 0 0 7 7 7 0 AP2 domain Sel1 PF08238.12 EDO08350.1 - 3e-22 78.5 21.6 6.4e-06 26.7 0.0 9.5 10 0 0 10 10 10 5 Sel1 repeat TPR_16 PF13432.6 EDO08350.1 - 0.0086 16.7 18.6 0.97 10.1 0.1 7.2 8 1 1 9 9 9 1 Tetratricopeptide repeat Tom7 PF08038.12 EDO08350.1 - 0.15 11.7 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 TOM7 family TPR_12 PF13424.6 EDO08350.1 - 0.36 11.1 5.7 0.54 10.6 0.1 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 EDO08350.1 - 0.67 10.1 3.1 28 5.0 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat SART-1 PF03343.13 EDO08352.1 - 1.4e-47 162.7 18.5 1.7e-25 89.7 12.6 3.6 1 1 1 2 2 2 2 SART-1 family BSD PF03909.17 EDO08353.1 - 0.00069 19.6 0.1 0.34 10.9 0.0 3.0 2 0 0 2 2 2 2 BSD domain HAT_KAT11 PF08214.11 EDO08354.1 - 0.047 13.0 1.7 0.07 12.4 1.7 1.4 1 0 0 1 1 1 0 Histone acetylation protein SesA PF17107.5 EDO08354.1 - 0.13 12.5 4.7 0.85 9.8 0.2 2.5 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases TUDOR PF00567.24 EDO08354.1 - 0.23 11.5 5.8 0.59 10.2 0.5 3.2 2 2 2 4 4 4 0 Tudor domain eIF3g PF12353.8 EDO08354.1 - 4.3 7.7 8.8 0.44 10.9 3.5 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G AAA_23 PF13476.6 EDO08354.1 - 6.5 7.2 12.9 5.4 7.5 0.5 2.2 2 0 0 2 2 2 0 AAA domain Enolase_C PF00113.22 EDO08355.1 - 3.7e-150 499.2 0.1 4.5e-150 498.9 0.1 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 EDO08355.1 - 2e-52 176.8 0.1 3.2e-52 176.1 0.1 1.3 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 EDO08355.1 - 1.2e-06 28.2 0.0 2.3e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 EDO08355.1 - 8.8e-06 25.0 0.2 1.5e-05 24.3 0.2 1.3 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus B-block_TFIIIC PF04182.12 EDO08357.1 - 0.0062 16.7 0.0 0.036 14.2 0.0 2.2 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC HTH_micro PF17007.5 EDO08358.1 - 0.032 13.1 0.0 3 6.5 0.0 2.2 2 0 0 2 2 2 0 HTH-like Maf PF02545.14 EDO08359.1 - 4.2e-36 124.3 0.0 1.4e-35 122.6 0.0 1.7 1 1 0 1 1 1 1 Maf-like protein 2-Hacid_dh PF00389.30 EDO08359.1 - 0.058 13.1 0.0 0.071 12.8 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain eRF1_1 PF03463.15 EDO08360.1 - 1.5e-30 105.9 0.1 3.3e-30 104.7 0.1 1.6 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_3 PF03465.15 EDO08360.1 - 6.2e-15 55.7 1.1 2e-14 54.0 0.1 2.3 3 0 0 3 3 3 1 eRF1 domain 3 eRF1_2 PF03464.15 EDO08360.1 - 1e-10 42.0 0.1 2.4e-10 40.8 0.0 1.7 2 0 0 2 2 2 1 eRF1 domain 2 Pam16 PF03656.13 EDO08361.1 - 3.5e-10 40.0 0.0 3.8e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 Pam16 DnaJ PF00226.31 EDO08361.1 - 2.4e-06 27.6 0.0 3.3e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain E1_dh PF00676.20 EDO08361.1 - 0.042 12.8 0.0 0.044 12.7 0.0 1.1 1 0 0 1 1 1 0 Dehydrogenase E1 component RWP-RK PF02042.15 EDO08361.1 - 0.13 12.3 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 RWP-RK domain DUF1279 PF06916.13 EDO08362.1 - 4.3e-08 33.6 0.3 4.3e-08 33.6 0.3 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1279) FPL PF09758.9 EDO08364.1 - 9.3e-32 110.1 5.1 1e-31 109.9 3.5 1.9 2 0 0 2 2 2 1 Uncharacterised conserved protein RepL PF05732.11 EDO08364.1 - 0.22 10.9 1.3 0.43 10.0 1.3 1.4 1 0 0 1 1 1 0 Firmicute plasmid replication protein (RepL) DUF3395 PF11875.8 EDO08365.1 - 2.9e-21 76.0 0.0 4.8e-21 75.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 EDO08365.1 - 2.3e-14 53.2 0.3 4.2e-14 52.4 0.3 1.4 1 0 0 1 1 1 1 DnaJ domain DUF1279 PF06916.13 EDO08365.1 - 0.0022 18.5 0.0 0.0047 17.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) PET PF06297.14 EDO08365.1 - 0.022 15.0 0.1 0.057 13.7 0.1 1.6 1 0 0 1 1 1 0 PET Domain Ribosomal_L27 PF01016.19 EDO08366.1 - 1.1e-11 44.6 0.7 7e-11 42.0 0.7 1.9 1 1 0 1 1 1 1 Ribosomal L27 protein Pinin_SDK_memA PF04696.13 EDO08368.1 - 1e-12 48.2 5.5 1e-12 48.2 5.5 1.9 2 0 0 2 2 2 1 pinin/SDK/memA/ protein conserved region CASP_C PF08172.12 EDO08368.1 - 0.0081 15.5 6.2 0.2 10.9 0.4 2.2 2 0 0 2 2 2 2 CASP C terminal Leu_zip PF15294.6 EDO08368.1 - 0.05 13.1 14.9 0.13 11.7 8.8 2.1 1 1 0 2 2 2 0 Leucine zipper DDE_Tnp_ISL3 PF01610.17 EDO08368.1 - 0.052 13.3 1.4 0.089 12.5 1.4 1.4 1 0 0 1 1 1 0 Transposase Spc7 PF08317.11 EDO08368.1 - 0.07 12.0 8.1 0.12 11.3 3.4 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Uds1 PF15456.6 EDO08368.1 - 0.08 13.1 8.8 0.74 10.0 0.2 2.3 2 0 0 2 2 2 0 Up-regulated During Septation Rootletin PF15035.6 EDO08368.1 - 0.089 12.8 10.2 0.38 10.8 3.7 2.2 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion JIP_LZII PF16471.5 EDO08368.1 - 0.29 11.3 8.7 1.3 9.3 2.6 2.6 2 1 0 2 2 2 0 JNK-interacting protein leucine zipper II Dynein_C PF18199.1 EDO08368.1 - 0.36 10.0 4.8 0.69 9.1 4.2 1.6 1 1 0 1 1 1 0 Dynein heavy chain C-terminal domain OmpH PF03938.14 EDO08368.1 - 0.46 10.8 6.3 0.92 9.8 6.3 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) MIF4G_like_2 PF09090.11 EDO08368.1 - 0.49 9.8 5.8 0.059 12.8 1.6 1.5 2 0 0 2 2 2 0 MIF4G like Prefoldin PF02996.17 EDO08368.1 - 0.52 10.2 7.8 14 5.6 4.5 2.3 2 0 0 2 2 2 0 Prefoldin subunit TMPIT PF07851.13 EDO08368.1 - 0.56 9.4 5.8 0.35 10.1 4.1 1.5 1 1 1 2 2 2 0 TMPIT-like protein Seryl_tRNA_N PF02403.22 EDO08368.1 - 0.8 10.0 9.2 0.19 12.0 5.6 1.7 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain HBS1_N PF08938.10 EDO08368.1 - 1.3 9.4 4.8 3.9 7.8 4.8 1.9 1 1 0 1 1 1 0 HBS1 N-terminus Syntaxin_2 PF14523.6 EDO08368.1 - 4.7 7.6 9.3 2.4 8.6 5.4 2.3 2 1 0 2 2 2 0 Syntaxin-like protein DASH_Spc19 PF08287.11 EDO08368.1 - 6 6.7 16.1 3.6e+02 0.9 16.0 2.4 1 1 0 1 1 1 0 Spc19 eIF3_p135 PF12807.7 EDO08369.1 - 5.6e-08 33.0 0.0 1.1e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 CLU PF13236.6 EDO08369.1 - 0.0018 18.2 0.0 0.0031 17.4 0.0 1.3 1 0 0 1 1 1 1 Clustered mitochondria TPR_2 PF07719.17 EDO08369.1 - 0.081 13.1 0.2 1.5 9.1 0.1 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF2718 PF10918.8 EDO08370.1 - 0.085 13.4 0.2 14 6.2 0.0 3.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2718) DEAD PF00270.29 EDO08371.1 - 5.5e-13 49.1 0.0 9.5e-13 48.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EDO08371.1 - 0.0075 16.3 0.0 0.021 14.8 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Ribosomal_60s PF00428.19 EDO08372.1 - 2.8e-25 88.7 9.0 3.5e-25 88.4 9.0 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Cytochrom_C PF00034.21 EDO08373.1 - 8e-08 33.3 0.0 1.2e-07 32.7 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 EDO08373.1 - 0.00014 22.1 1.1 0.00037 20.8 1.1 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 EDO08373.1 - 0.00083 19.1 1.9 0.014 15.1 0.4 2.4 1 1 1 2 2 2 1 Cytochrome c-550 domain Cytochrom_C1 PF02167.15 EDO08373.1 - 0.011 15.4 0.1 0.018 14.8 0.1 1.2 1 0 0 1 1 1 0 Cytochrome C1 family Haem_bd PF14376.6 EDO08373.1 - 0.069 13.1 0.0 0.097 12.6 0.0 1.2 1 0 0 1 1 1 0 Haem-binding domain ATP-synt_ab PF00006.25 EDO08375.1 - 2.6e-97 324.6 0.0 3.8e-97 324.1 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 EDO08375.1 - 9.2e-37 125.6 0.0 1.6e-36 124.8 0.0 1.4 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 EDO08375.1 - 4.5e-16 59.1 1.8 7.3e-16 58.4 0.3 2.1 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain Amidohydro_1 PF01979.20 EDO08375.1 - 0.07 12.4 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Amidohydrolase family GYF PF02213.16 EDO08376.1 - 0.057 13.1 0.9 0.12 12.1 0.9 1.6 1 0 0 1 1 1 0 GYF domain AAA_12 PF13087.6 EDO08377.1 - 1.1e-62 211.2 0.0 1.7e-62 210.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EDO08377.1 - 1.6e-59 201.9 0.1 1.2e-28 100.6 0.0 2.3 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 EDO08377.1 - 1.2e-10 41.4 0.0 1.6e-05 24.7 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_19 PF13245.6 EDO08377.1 - 7.4e-08 32.8 0.0 0.0033 17.8 0.0 3.0 3 1 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.18 EDO08377.1 - 1.1e-06 28.6 0.1 0.00085 19.1 0.0 2.9 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase T2SSE PF00437.20 EDO08377.1 - 0.0057 15.7 0.0 0.011 14.9 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein UvrD-helicase PF00580.21 EDO08377.1 - 0.012 15.1 0.0 0.48 9.9 0.0 2.6 2 1 1 3 3 3 0 UvrD/REP helicase N-terminal domain Helicase_RecD PF05127.14 EDO08377.1 - 0.012 15.4 0.0 0.54 10.1 0.0 3.0 2 1 0 2 2 2 0 Helicase DUF3477 PF11963.8 EDO08377.1 - 0.017 14.4 0.2 0.029 13.6 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3477) AAA PF00004.29 EDO08377.1 - 0.05 14.0 0.0 0.16 12.4 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDO08377.1 - 0.056 13.7 0.1 0.3 11.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EDO08377.1 - 0.056 13.8 0.0 0.14 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 EDO08377.1 - 0.092 12.3 0.5 0.8 9.2 0.0 2.7 3 0 0 3 3 3 0 P-loop containing dynein motor region AAA_25 PF13481.6 EDO08377.1 - 0.12 12.0 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EDO08377.1 - 0.13 12.2 0.0 0.71 9.8 0.0 2.2 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_23 PF13476.6 EDO08377.1 - 0.13 12.7 0.0 0.25 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EDO08377.1 - 0.14 11.9 0.1 0.32 10.8 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ResIII PF04851.15 EDO08377.1 - 0.15 12.1 0.0 0.97 9.4 0.0 2.1 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit RNA_helicase PF00910.22 EDO08377.1 - 0.15 12.5 0.0 0.6 10.5 0.0 2.0 2 0 0 2 2 1 0 RNA helicase AAA_24 PF13479.6 EDO08377.1 - 0.21 11.3 0.5 9.3 5.9 0.1 2.4 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 EDO08377.1 - 0.24 10.6 0.0 1.5 8.0 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Acetyltransf_1 PF00583.25 EDO08378.1 - 3.2e-06 27.4 0.0 4.4e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDO08378.1 - 6.3e-06 26.5 0.0 1.1e-05 25.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EDO08378.1 - 8.5e-06 25.7 0.0 1.7e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDO08378.1 - 0.069 13.1 0.0 0.21 11.6 0.0 1.7 2 0 0 2 2 2 0 FR47-like protein Acetyltransf_9 PF13527.7 EDO08378.1 - 0.094 12.8 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Rhodanese PF00581.20 EDO08378.1 - 0.1 13.2 0.1 0.2 12.2 0.1 1.5 1 0 0 1 1 1 0 Rhodanese-like domain DUF1359 PF07097.11 EDO08379.1 - 0.0022 18.2 1.4 1.6 9.0 0.1 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF1359) Rac1 PF09632.10 EDO08379.1 - 0.014 14.5 2.0 0.059 12.5 0.0 2.6 2 1 1 3 3 3 0 Rac1-binding domain Casc1_N PF15927.5 EDO08379.1 - 0.82 9.3 8.3 0.25 11.0 3.9 2.3 2 1 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus E1_dh PF00676.20 EDO08380.1 - 1.5e-82 276.9 0.1 1.9e-82 276.6 0.1 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component Rap1_C PF11626.8 EDO08380.1 - 0.17 12.0 0.1 0.41 10.8 0.1 1.7 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain MRP-S28 PF10213.9 EDO08382.1 - 1.5e-10 41.6 0.0 2.9e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein RRM_1 PF00076.22 EDO08385.1 - 2.9e-10 39.8 0.0 4.4e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDO08385.1 - 0.0006 19.6 0.0 0.00074 19.3 0.0 1.1 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_3 PF08777.11 EDO08385.1 - 0.014 15.4 0.0 0.016 15.3 0.0 1.2 1 0 0 1 1 1 0 RNA binding motif RRM_5 PF13893.6 EDO08385.1 - 0.092 12.3 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EDO08385.1 - 0.096 12.8 0.0 0.1 12.7 0.0 1.3 1 1 0 1 1 1 0 Limkain b1 DEAD PF00270.29 EDO08387.1 - 6.4e-32 110.7 1.3 1.2e-31 109.9 1.3 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO08387.1 - 4.8e-21 75.2 0.2 1.8e-20 73.4 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO08387.1 - 0.022 14.8 0.0 8.6 6.3 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit YEATS PF03366.16 EDO08388.1 - 1.3e-27 95.5 0.2 2.3e-27 94.8 0.2 1.4 1 0 0 1 1 1 1 YEATS family Mustang PF15682.5 EDO08388.1 - 0.17 12.0 0.0 11 6.2 0.0 2.5 2 1 0 2 2 2 0 Musculoskeletal, temporally activated-embryonic nuclear protein 1 V_ATPase_I PF01496.19 EDO08390.1 - 8.3e-252 837.7 4.5 9.5e-252 837.5 4.5 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF5313 PF17240.2 EDO08390.1 - 0.023 15.1 0.4 0.065 13.7 0.4 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5313) SAS4 PF15460.6 EDO08390.1 - 0.091 12.9 0.6 0.32 11.1 0.6 1.9 1 0 0 1 1 1 0 Something about silencing, SAS, complex subunit 4 DUF4795 PF16043.5 EDO08390.1 - 0.44 10.1 4.8 4.9 6.7 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) MMR_HSR1 PF01926.23 EDO08391.1 - 2e-17 63.3 0.0 3.9e-17 62.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase IIGP PF05049.13 EDO08391.1 - 5.7e-06 25.6 0.0 1.2e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) FeoB_N PF02421.18 EDO08391.1 - 5e-05 22.9 0.0 0.00012 21.6 0.0 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EDO08391.1 - 0.00066 19.6 0.0 0.033 14.1 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EDO08391.1 - 0.0012 18.4 0.1 0.028 14.0 0.1 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EDO08391.1 - 0.0021 18.2 0.1 1.1 9.3 0.1 2.6 1 1 1 2 2 2 2 Dynamin family Septin PF00735.18 EDO08391.1 - 0.0024 17.2 0.0 0.0049 16.2 0.0 1.6 1 0 0 1 1 1 1 Septin Roc PF08477.13 EDO08391.1 - 0.0035 17.6 0.1 0.027 14.7 0.0 2.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EDO08391.1 - 0.005 16.7 1.5 2.6 7.8 0.3 2.6 1 1 1 2 2 2 2 Conserved hypothetical ATP binding protein AIG1 PF04548.16 EDO08391.1 - 0.026 13.8 0.1 0.045 13.1 0.1 1.4 1 0 0 1 1 1 0 AIG1 family Ribosomal_L3 PF00297.22 EDO08392.1 - 5.4e-12 45.4 4.5 1.3e-09 37.5 2.3 2.8 2 1 1 3 3 3 2 Ribosomal protein L3 Plant_all_beta PF10532.9 EDO08393.1 - 0.07 13.4 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 Plant specific N-all beta domain Nucleoporin2 PF04096.14 EDO08394.1 - 4.9e-31 107.8 0.0 8.4e-31 107.1 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 EDO08394.1 - 1.8e-29 102.4 252.9 3.3e-12 47.1 34.1 9.2 2 2 5 7 7 7 6 Nucleoporin FG repeat region HMG_CoA_synt_C PF08540.10 EDO08394.1 - 0.41 10.2 1.1 0.75 9.4 1.1 1.3 1 0 0 1 1 1 0 Hydroxymethylglutaryl-coenzyme A synthase C terminal Ribosomal_S21e PF01249.18 EDO08395.1 - 7.1e-32 109.4 0.0 7.7e-32 109.2 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e Img2 PF05046.14 EDO08396.1 - 1.5e-19 70.0 0.0 2e-19 69.7 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) Creatinase_N_2 PF16189.5 EDO08397.1 - 6.3e-44 149.9 0.0 2e-42 145.0 0.0 2.7 3 0 0 3 3 3 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 EDO08397.1 - 8.8e-41 139.9 0.1 1.4e-40 139.3 0.1 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 EDO08397.1 - 1.8e-18 66.4 0.1 3.6e-18 65.4 0.1 1.6 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 EDO08397.1 - 3e-14 53.8 0.0 1.3e-10 42.0 0.0 2.4 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain eIF-3c_N PF05470.12 EDO08398.1 - 1.4e-94 317.5 36.7 1e-92 311.4 36.7 2.4 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 EDO08398.1 - 8e-11 42.4 0.8 1e-09 38.8 0.0 2.9 3 0 0 3 3 3 1 PCI domain DUF2089 PF09862.9 EDO08398.1 - 0.033 14.2 0.4 0.12 12.5 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2089) Suf PF05843.14 EDO08398.1 - 2.1 8.3 6.8 1.3 9.0 0.0 2.5 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DDRGK PF09756.9 EDO08398.1 - 6.5 6.3 15.0 0.23 11.0 0.1 2.8 3 0 0 3 3 3 0 DDRGK domain tRNA-synt_1 PF00133.22 EDO08399.1 - 9.1e-187 622.0 0.0 1.5e-185 617.9 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EDO08399.1 - 8.2e-40 136.2 0.0 1.6e-39 135.3 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EDO08399.1 - 2.7e-16 59.3 0.3 1.7e-07 30.4 0.0 4.3 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EDO08399.1 - 6.8e-08 32.2 0.5 7e-07 28.9 0.0 2.6 2 1 1 3 3 3 1 Leucyl-tRNA synthetase, Domain 2 Val_tRNA-synt_C PF10458.9 EDO08399.1 - 5.8e-06 26.5 1.9 5.8e-06 26.5 1.9 1.9 2 0 0 2 2 2 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1b PF00579.25 EDO08399.1 - 0.011 15.0 0.2 0.26 10.6 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) tRNA-synt_1c PF00749.21 EDO08399.1 - 0.048 12.6 0.0 0.11 11.3 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain Lzipper-MIP1 PF14389.6 EDO08399.1 - 1.6 9.1 5.7 1.2 9.4 2.5 2.2 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 UPF0020 PF01170.18 EDO08401.1 - 0.073 12.7 0.0 0.21 11.3 0.0 1.7 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 Rad9 PF04139.13 EDO08402.1 - 2.3e-16 60.0 0.0 3.5e-16 59.4 0.0 1.2 1 0 0 1 1 1 1 Rad9 PCNA_N PF00705.18 EDO08402.1 - 0.0057 16.4 0.0 0.013 15.2 0.0 1.6 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain NESP55 PF06390.12 EDO08402.1 - 0.06 12.9 3.7 0.085 12.4 3.7 1.2 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) TSGP1 PF07771.11 EDO08402.1 - 1.6 8.9 5.4 8.3 6.6 5.8 2.0 2 0 0 2 2 2 0 Tick salivary peptide group 1 RimM PF01782.18 EDO08403.1 - 7.5e-16 58.1 0.0 1.4e-15 57.3 0.0 1.5 1 0 0 1 1 1 1 RimM N-terminal domain APO_RNA-bind PF05634.11 EDO08403.1 - 0.01 15.2 1.0 0.41 10.0 0.0 2.8 2 1 0 2 2 2 1 APO RNA-binding zf-met PF12874.7 EDO08403.1 - 0.022 15.2 0.4 0.043 14.2 0.4 1.4 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf_UBZ PF18439.1 EDO08403.1 - 0.081 12.5 0.3 0.16 11.6 0.3 1.5 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger zf-C2H2_6 PF13912.6 EDO08403.1 - 0.13 12.3 0.4 0.25 11.4 0.4 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EDO08403.1 - 0.14 13.0 0.7 0.57 11.2 0.2 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger Cyclin_C PF02984.19 EDO08405.1 - 0.0057 16.7 1.2 0.079 13.1 0.2 2.5 2 0 0 2 2 2 1 Cyclin, C-terminal domain Cyclin_N PF00134.23 EDO08405.1 - 0.013 15.3 0.1 0.89 9.3 0.0 2.4 2 0 0 2 2 2 0 Cyclin, N-terminal domain HCMVantigenic_N PF12154.8 EDO08405.1 - 0.85 9.8 3.4 8.3 6.6 1.3 2.8 2 0 0 2 2 2 0 Glycoprotein B N-terminal antigenic domain of HCMV Ribosomal_S2 PF00318.20 EDO08406.1 - 1.2e-28 99.8 0.7 1.8e-13 50.2 0.1 2.2 1 1 1 2 2 2 2 Ribosomal protein S2 DDR_swiveling PF18427.1 EDO08406.1 - 0.077 13.0 0.1 0.21 11.6 0.0 1.6 2 0 0 2 2 2 0 DD-reactivating factor swiveling domain PPI_Ypi1 PF07491.11 EDO08407.1 - 2.4e-18 65.7 2.0 3.6e-18 65.1 2.0 1.3 1 0 0 1 1 1 1 Protein phosphatase inhibitor Surp PF01805.20 EDO08409.1 - 5.3e-16 58.4 0.5 1.4e-15 57.0 0.0 2.0 2 0 0 2 2 2 1 Surp module RRM_1 PF00076.22 EDO08409.1 - 1.1e-10 41.1 0.0 2.8e-10 39.9 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTD_bind PF04818.13 EDO08409.1 - 0.00014 22.6 0.2 0.00037 21.3 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_occluded PF16842.5 EDO08409.1 - 0.0064 16.3 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 Occluded RNA-recognition motif Ribosomal_S27 PF01599.19 EDO08410.1 - 4.5e-22 77.9 4.2 1.1e-21 76.7 4.2 1.7 1 0 0 1 1 1 1 Ribosomal protein S27a ubiquitin PF00240.23 EDO08410.1 - 0.00022 20.9 0.0 0.00097 18.9 0.0 2.1 2 2 0 2 2 2 1 Ubiquitin family UBX PF00789.20 EDO08410.1 - 0.06 13.5 0.0 12 6.1 0.0 2.2 2 0 0 2 2 2 0 UBX domain Fer2_3 PF13085.6 EDO08410.1 - 0.24 11.4 1.9 0.51 10.4 1.9 1.6 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain WW PF00397.26 EDO08411.1 - 1.2e-05 25.2 2.0 4.6e-05 23.4 0.1 2.4 2 0 0 2 2 2 1 WW domain Myticin-prepro PF10690.9 EDO08411.1 - 0.16 12.2 0.9 5.2 7.4 0.0 2.3 2 0 0 2 2 2 0 Myticin pre-proprotein from the mussel zf-U1 PF06220.12 EDO08411.1 - 0.33 10.7 3.6 0.91 9.4 3.6 1.8 1 1 0 1 1 1 0 U1 zinc finger zf-C2H2_jaz PF12171.8 EDO08411.1 - 2.2 8.7 6.1 4.5 7.7 0.7 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding SAC3_GANP PF03399.16 EDO08413.1 - 2.7e-43 148.4 2.5 9.2e-43 146.7 2.5 1.9 1 1 0 1 1 1 1 SAC3/GANP family Nucleoporin_FG PF13634.6 EDO08413.1 - 0.0039 18.0 130.9 0.12 13.3 21.8 6.7 1 1 6 7 7 7 5 Nucleoporin FG repeat region DCP1 PF06058.13 EDO08414.1 - 8e-31 106.4 0.0 1.6e-30 105.5 0.0 1.5 1 0 0 1 1 1 1 Dcp1-like decapping family PIGA PF08288.12 EDO08416.1 - 6.2e-33 113.2 0.4 1.6e-32 111.9 0.4 1.7 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glycos_transf_1 PF00534.20 EDO08416.1 - 2.7e-23 82.4 0.0 3.7e-23 81.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EDO08416.1 - 1.3e-19 71.0 0.0 3.1e-19 69.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EDO08416.1 - 4.4e-14 52.8 0.3 1.1e-13 51.5 0.1 1.8 1 1 1 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 EDO08416.1 - 2.3e-06 28.1 0.0 4.3e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 EDO08416.1 - 0.011 16.1 0.0 0.03 14.7 0.0 1.8 1 1 0 1 1 1 0 Glycosyl transferases group 1 WD40 PF00400.32 EDO08417.1 - 0.027 15.3 5.3 0.13 13.2 0.2 3.7 3 0 0 3 3 3 0 WD domain, G-beta repeat WD40_like PF17005.5 EDO08417.1 - 0.13 11.5 2.4 0.12 11.7 0.5 1.8 3 0 0 3 3 3 0 WD40-like domain PCI PF01399.27 EDO08418.1 - 3.7e-18 66.0 1.3 3.7e-18 66.0 1.3 2.4 3 0 0 3 3 3 1 PCI domain RPN6_N PF18055.1 EDO08418.1 - 3.2e-08 33.9 0.5 2.5e-07 31.0 0.0 2.5 2 1 0 2 2 2 1 26S proteasome regulatory subunit RPN6 N-terminal domain DDRGK PF09756.9 EDO08418.1 - 0.052 13.1 0.4 0.088 12.4 0.4 1.3 1 0 0 1 1 1 0 DDRGK domain TFIID-31kDa PF02291.15 EDO08419.1 - 9.7e-06 25.7 0.0 1.4e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit DER1 PF04511.15 EDO08420.1 - 5.8e-30 104.6 19.3 7.3e-30 104.3 19.3 1.0 1 0 0 1 1 1 1 Der1-like family DUF2627 PF11118.8 EDO08420.1 - 0.52 10.9 4.0 3.7 8.2 4.0 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2627) DUF155 PF02582.14 EDO08421.1 - 3.6e-09 37.0 0.2 4.9e-09 36.5 0.2 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 RRM_1 PF00076.22 EDO08422.1 - 4.8e-28 96.8 0.5 4.2e-14 52.1 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO08422.1 - 3.5e-11 43.1 0.3 1.9e-06 27.9 0.1 2.8 2 1 0 2 2 2 2 RNA recognition motif B12-binding PF02310.19 EDO08422.1 - 0.02 14.9 0.0 1.3 9.1 0.0 2.3 2 0 0 2 2 2 0 B12 binding domain UCH PF00443.29 EDO08423.1 - 6.1e-38 130.8 0.0 8.5e-38 130.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDO08423.1 - 2.1e-08 34.1 0.2 9.9e-07 28.6 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EDO08423.1 - 4.7e-08 32.7 0.0 1.7e-07 30.9 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin family Thermopsin PF05317.11 EDO08424.1 - 5.4e-06 26.1 4.7 9.1e-06 25.3 4.7 1.2 1 0 0 1 1 1 1 Thermopsin Peptidase_M24 PF00557.24 EDO08425.1 - 5e-41 140.7 0.5 5.9e-41 140.5 0.5 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 EF-hand_7 PF13499.6 EDO08426.1 - 1e-14 54.7 1.3 2.1e-07 31.3 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EDO08426.1 - 1.3e-14 52.5 1.4 3.1e-06 26.4 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EDO08426.1 - 1.9e-13 49.1 1.9 6.3e-06 25.7 0.0 2.8 2 1 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EDO08426.1 - 2.8e-11 42.4 0.6 7.7e-06 25.2 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EDO08426.1 - 3.8e-09 36.3 1.5 0.0018 18.1 0.0 3.6 2 2 2 4 4 4 2 EF-hand domain pair EF-hand_9 PF14658.6 EDO08426.1 - 0.011 16.0 0.2 1.3 9.4 0.0 2.6 1 1 1 3 3 3 0 EF-hand domain UPF0154 PF03672.13 EDO08426.1 - 0.092 12.8 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) Caleosin PF05042.13 EDO08426.1 - 0.12 12.3 0.0 5.6 6.9 0.0 2.1 2 0 0 2 2 2 0 Caleosin related protein Ribosomal_L26 PF16906.5 EDO08427.1 - 3.4e-38 130.0 4.5 4.4e-38 129.6 4.5 1.1 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 EDO08427.1 - 6.2e-08 32.3 0.6 1.4e-07 31.2 0.6 1.6 1 0 0 1 1 1 1 KOW motif SNF2_N PF00176.23 EDO08428.1 - 1.8e-53 181.5 1.2 1.6e-27 96.2 0.2 3.0 2 2 1 3 3 3 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EDO08428.1 - 7.5e-17 61.7 0.0 2.6e-16 59.9 0.0 2.0 2 0 0 2 2 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EDO08428.1 - 0.00029 20.1 0.0 0.00055 19.2 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase zf-RING_11 PF17123.5 EDO08428.1 - 0.00054 19.7 4.8 0.0019 17.9 4.8 2.0 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 EDO08428.1 - 0.001 19.4 9.0 0.001 19.4 9.0 2.8 2 0 0 2 2 2 1 Ring finger domain zf-C2HC_2 PF13913.6 EDO08428.1 - 0.0011 18.8 0.0 0.0036 17.2 0.0 1.8 1 0 0 1 1 1 1 zinc-finger of a C2HC-type zf-RING_5 PF14634.6 EDO08428.1 - 0.0018 18.2 9.4 0.0018 18.2 9.4 2.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EDO08428.1 - 0.0034 17.4 2.2 0.0034 17.4 2.2 3.1 3 1 1 4 4 4 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EDO08428.1 - 0.0042 16.9 9.4 0.0042 16.9 9.4 2.9 3 0 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EDO08428.1 - 0.012 15.9 7.6 0.017 15.4 5.0 2.7 2 0 0 2 2 2 0 RING-H2 zinc finger domain ResIII PF04851.15 EDO08428.1 - 0.022 14.7 0.7 0.061 13.3 0.1 2.1 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit SAP PF02037.27 EDO08428.1 - 0.023 14.5 0.0 0.063 13.0 0.0 1.8 1 0 0 1 1 1 0 SAP domain zf-ANAPC11 PF12861.7 EDO08428.1 - 0.039 14.0 1.7 0.12 12.4 1.7 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF3235 PF11574.8 EDO08428.1 - 0.11 13.4 0.1 0.51 11.2 0.1 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3235) WD40 PF00400.32 EDO08429.1 - 1e-09 38.8 15.7 0.0006 20.6 0.4 5.5 6 1 1 7 7 7 2 WD domain, G-beta repeat DUF1899 PF08953.11 EDO08429.1 - 3e-07 30.2 0.0 8.6e-07 28.8 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) ANAPC4_WD40 PF12894.7 EDO08429.1 - 2e-06 28.0 0.6 0.09 13.1 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDO08429.1 - 0.0011 18.9 0.9 0.0035 17.3 0.4 1.9 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EDO08429.1 - 0.013 14.2 0.4 0.034 12.8 0.1 1.7 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 EDO08429.1 - 0.057 12.4 0.3 0.11 11.5 0.3 1.4 1 1 0 1 1 1 0 Coatomer WD associated region DEAD PF00270.29 EDO08431.1 - 1.8e-42 145.1 1.7 2.1e-42 144.9 0.4 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO08431.1 - 7.4e-25 87.5 0.1 1.4e-22 80.1 0.0 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EDO08431.1 - 0.083 13.2 0.5 1.8 8.8 0.1 2.7 2 0 0 2 2 2 0 AAA domain tRNA-synt_1b PF00579.25 EDO08433.1 - 7.4e-52 176.5 0.0 9.2e-52 176.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) BAG6 PF12057.8 EDO08433.1 - 0.018 14.7 0.0 0.041 13.6 0.0 1.5 1 0 0 1 1 1 0 BCL2-associated athanogene 6 Anti-adapt_IraP PF10796.9 EDO08433.1 - 0.18 12.4 0.1 0.91 10.1 0.0 2.0 2 0 0 2 2 2 0 Sigma-S stabilisation anti-adaptor protein Pkinase PF00069.25 EDO08434.1 - 1.8e-50 171.8 0.0 2.8e-50 171.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO08434.1 - 1.7e-28 99.6 0.0 3.3e-28 98.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO08434.1 - 0.0024 17.2 0.0 0.0039 16.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like TSKS PF15358.6 EDO08435.1 - 0.13 10.6 0.0 0.18 10.1 0.0 1.1 1 0 0 1 1 1 0 Testis-specific serine kinase substrate PHM7_cyt PF14703.6 EDO08436.1 - 8.8e-14 52.1 5.2 5.3e-08 33.3 0.1 3.0 3 0 0 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter Vps26 PF03643.15 EDO08437.1 - 3.2e-77 259.2 1.8 5.2e-65 219.2 3.2 2.0 1 1 1 2 2 2 2 Vacuolar protein sorting-associated protein 26 VID27_N PF17748.1 EDO08437.1 - 0.092 12.6 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 VID27 N-terminal region TPR_1 PF00515.28 EDO08438.1 - 0.17 11.8 2.8 1.8 8.5 1.4 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Helicase_C_2 PF13307.6 EDO08439.1 - 5.9e-54 182.8 0.1 1.8e-53 181.2 0.0 1.9 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 EDO08439.1 - 3.9e-46 156.9 0.3 3.9e-46 156.9 0.3 2.0 2 0 0 2 2 2 1 DEAD_2 DEAD PF00270.29 EDO08439.1 - 3.4e-05 23.7 0.7 0.00079 19.2 0.2 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EDO08439.1 - 0.0014 18.6 1.0 0.16 11.9 0.3 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF3939 PF13075.6 EDO08439.1 - 0.029 14.4 0.2 0.064 13.3 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3939) AAA_11 PF13086.6 EDO08439.1 - 0.092 12.5 0.1 0.092 12.5 0.1 1.6 2 0 0 2 2 2 0 AAA domain DUF4011 PF13195.6 EDO08439.1 - 0.12 12.3 0.2 0.27 11.1 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4011) AAA_22 PF13401.6 EDO08439.1 - 0.2 11.9 0.4 7 6.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain Astro_capsid_p PF12226.8 EDO08440.1 - 0.6 9.2 14.9 0.84 8.7 14.9 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Cwf_Cwc_15 PF04889.12 EDO08440.1 - 2.9 7.5 19.0 2.6 7.7 16.0 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein LsmAD PF06741.13 EDO08441.1 - 2.4e-09 37.6 0.3 2.4e-09 37.6 0.3 2.4 2 0 0 2 2 2 1 LsmAD domain PAM2 PF07145.15 EDO08441.1 - 0.066 12.9 1.8 0.22 11.3 1.8 2.0 1 0 0 1 1 1 0 Ataxin-2 C-terminal region SM-ATX PF14438.6 EDO08441.1 - 0.077 13.2 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 Ataxin 2 SM domain MMR_HSR1 PF01926.23 EDO08442.1 - 3.8e-18 65.6 0.0 6.8e-18 64.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDO08442.1 - 3.1e-06 26.8 0.0 0.00023 20.7 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EDO08442.1 - 1.3e-05 25.2 0.0 0.019 14.9 0.0 2.6 3 0 0 3 3 3 2 RsgA GTPase Arf PF00025.21 EDO08442.1 - 2.8e-05 23.6 0.1 0.0024 17.4 0.1 2.8 2 1 0 2 2 2 1 ADP-ribosylation factor family Dynamin_N PF00350.23 EDO08442.1 - 0.00063 19.8 0.0 0.014 15.4 0.1 2.2 1 1 1 2 2 2 1 Dynamin family GTP_EFTU PF00009.27 EDO08442.1 - 0.0021 17.6 0.0 0.24 10.9 0.0 3.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 EDO08442.1 - 0.0034 17.4 0.0 0.0079 16.2 0.0 1.6 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain cobW PF02492.19 EDO08442.1 - 0.0047 16.5 0.1 0.18 11.4 0.0 2.5 2 1 1 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 EDO08442.1 - 0.0088 15.8 0.0 0.15 11.8 0.0 2.5 3 0 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation KH_2 PF07650.17 EDO08442.1 - 0.012 15.4 0.0 0.073 12.9 0.0 2.2 2 0 0 2 2 2 0 KH domain Gtr1_RagA PF04670.12 EDO08442.1 - 0.017 14.5 0.0 0.043 13.2 0.0 1.7 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Ras PF00071.22 EDO08442.1 - 0.051 13.2 0.0 0.62 9.6 0.0 2.3 2 0 0 2 2 2 0 Ras family GBP PF02263.19 EDO08442.1 - 0.072 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain Roc PF08477.13 EDO08442.1 - 0.089 13.0 0.0 4.8 7.4 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 EDO08442.1 - 0.098 13.0 0.0 0.59 10.5 0.0 2.1 1 1 0 1 1 1 0 RNA helicase Ubiq_cyt_C_chap PF03981.12 EDO08443.1 - 1.7e-08 34.6 1.6 2.4e-08 34.2 1.6 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone ACDC PF14733.6 EDO08444.1 - 3.9e-23 81.6 4.0 6e-23 81.0 4.0 1.3 1 0 0 1 1 1 1 AP2-coincident C-terminal AP2 PF00847.20 EDO08444.1 - 5e-18 65.1 1.1 9.5e-18 64.2 1.1 1.5 1 0 0 1 1 1 1 AP2 domain Pkinase PF00069.25 EDO08445.1 - 2.4e-38 132.0 0.0 3.7e-36 124.8 0.0 2.8 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO08445.1 - 1.8e-14 53.7 0.0 1.9e-11 43.7 0.0 3.4 2 1 0 2 2 2 2 Protein tyrosine kinase Trm112p PF03966.16 EDO08446.1 - 3.3e-10 40.4 0.0 1.1e-09 38.7 0.0 1.7 1 1 0 1 1 1 1 Trm112p-like protein SpoU_methylas_C PF12105.8 EDO08446.1 - 0.023 14.4 0.0 0.052 13.2 0.0 1.6 2 0 0 2 2 2 0 SpoU, rRNA methylase, C-terminal zinc_ribbon_4 PF13717.6 EDO08446.1 - 0.036 14.0 0.4 0.085 12.8 0.1 1.8 2 0 0 2 2 2 0 zinc-ribbon domain BTB_3 PF16017.5 EDO08446.1 - 0.13 12.3 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 BTB/POZ domain PRP38 PF03371.15 EDO08447.1 - 1.1e-47 162.1 1.5 1.8e-47 161.5 1.5 1.2 1 0 0 1 1 1 1 PRP38 family T2SSF PF00482.23 EDO08448.1 - 0.026 14.5 0.8 0.053 13.5 0.2 1.8 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F PAPS_reduct PF01507.19 EDO08448.1 - 0.036 14.1 3.9 0.29 11.1 3.9 2.0 1 1 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Bromo_TP_like PF17027.5 EDO08448.1 - 0.2 11.8 7.8 0.23 11.6 2.3 2.9 2 1 1 3 3 3 0 Histone-fold protein Spectrin PF00435.21 EDO08448.1 - 0.31 11.6 7.6 2.5 8.6 0.4 2.4 2 1 0 2 2 2 0 Spectrin repeat Noelin-1 PF12308.8 EDO08448.1 - 0.77 9.8 4.4 0.59 10.2 0.5 2.3 2 1 0 2 2 2 0 Neurogenesis glycoprotein Fibrillarin PF01269.17 EDO08449.1 - 3.1e-103 343.8 0.0 3.7e-103 343.5 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 EDO08449.1 - 0.00016 21.5 0.0 0.00024 20.9 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_11 PF08241.12 EDO08449.1 - 0.025 15.2 0.0 0.046 14.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltr_RsmB-F PF01189.17 EDO08449.1 - 0.049 13.3 0.0 0.092 12.4 0.0 1.4 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F LCCL PF03815.19 EDO08450.1 - 3.7e-80 264.1 12.5 3.8e-23 81.4 0.2 5.6 5 0 0 5 5 5 4 LCCL domain SRCR PF00530.18 EDO08450.1 - 4.7e-38 129.7 10.8 4.2e-19 68.9 0.9 3.0 3 0 0 3 3 3 2 Scavenger receptor cysteine-rich domain PLAT PF01477.23 EDO08450.1 - 7.2e-14 52.4 0.1 4.3e-11 43.4 0.0 2.6 2 0 0 2 2 2 2 PLAT/LH2 domain Rxt3 PF08642.10 EDO08450.1 - 3e-12 47.4 0.5 0.0044 17.8 0.0 3.5 3 0 0 3 3 3 3 Histone deacetylation protein Rxt3 SRCR_2 PF15494.6 EDO08450.1 - 8e-08 32.7 2.6 0.0022 18.5 1.2 2.8 2 1 0 2 2 2 2 Scavenger receptor cysteine-rich domain Laminin_G_3 PF13385.6 EDO08450.1 - 1.7e-07 31.5 0.0 3.5e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Hepsin-SRCR PF09272.10 EDO08450.1 - 9.8e-06 26.1 0.2 0.19 12.2 0.0 2.5 2 0 0 2 2 2 2 Hepsin, SRCR domain Radical_SAM PF04055.21 EDO08451.1 - 8.4e-14 52.3 0.0 2.7e-13 50.6 0.0 1.9 3 0 0 3 3 3 1 Radical SAM superfamily Fer4_14 PF13394.6 EDO08451.1 - 0.011 15.9 0.0 0.027 14.6 0.0 1.6 1 0 0 1 1 1 0 4Fe-4S single cluster domain Arg_decarb_HB PF17810.1 EDO08451.1 - 0.15 12.3 0.0 0.33 11.2 0.0 1.5 1 0 0 1 1 1 0 Arginine decarboxylase helical bundle domain T3SS_needle_reg PF09025.10 EDO08451.1 - 0.18 11.8 0.0 17 5.4 0.0 2.5 2 1 1 3 3 3 0 YopR, type III needle-polymerisation regulator DUF3273 PF11677.8 EDO08452.1 - 3.3e-109 364.3 7.4 4.1e-109 364.0 7.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) Metallophos_2 PF12850.7 EDO08454.1 - 4e-17 62.9 0.0 5.3e-17 62.5 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 EDO08454.1 - 0.00035 21.2 1.3 0.038 14.5 0.5 2.3 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase AAA_2 PF07724.14 EDO08455.1 - 1.9e-47 161.5 0.2 1.4e-46 158.8 0.1 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 EDO08455.1 - 2.1e-21 76.7 0.1 1.4e-09 38.5 0.0 3.6 4 0 0 4 4 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EDO08455.1 - 2e-19 69.9 0.1 8.3e-12 45.3 0.0 3.4 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_lid_9 PF17871.1 EDO08455.1 - 1.1e-17 63.8 0.2 4.6e-17 61.9 0.2 2.2 1 0 0 1 1 1 1 AAA lid domain Clp_N PF02861.20 EDO08455.1 - 4.7e-17 61.8 0.5 1.4e-07 31.5 0.1 2.9 2 0 0 2 2 2 2 Clp amino terminal domain, pathogenicity island component ClpB_D2-small PF10431.9 EDO08455.1 - 4.9e-15 55.4 0.2 2.9e-14 52.9 0.2 2.5 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_22 PF13401.6 EDO08455.1 - 1.8e-13 50.9 0.0 2.3e-05 24.7 0.1 3.9 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EDO08455.1 - 4.4e-10 40.2 0.0 0.00079 19.8 0.1 3.9 3 1 0 3 3 2 2 AAA ATPase domain AAA_18 PF13238.6 EDO08455.1 - 3.8e-07 30.7 0.6 0.0022 18.5 0.0 3.8 2 1 1 3 3 3 1 AAA domain Sigma54_activat PF00158.26 EDO08455.1 - 5e-07 29.6 0.0 3.8e-05 23.5 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 EDO08455.1 - 5.4e-07 29.2 0.0 0.038 13.4 0.0 3.5 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI TniB PF05621.11 EDO08455.1 - 4.4e-06 26.2 0.2 0.0029 17.0 0.1 3.9 3 2 1 4 4 3 1 Bacterial TniB protein AAA_33 PF13671.6 EDO08455.1 - 6.3e-06 26.4 0.1 0.18 12.0 0.0 3.6 2 1 0 2 2 2 2 AAA domain AAA_7 PF12775.7 EDO08455.1 - 1.1e-05 25.0 0.0 0.18 11.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region Zeta_toxin PF06414.12 EDO08455.1 - 1.2e-05 24.7 0.0 0.0046 16.3 0.0 3.4 3 0 0 3 3 3 1 Zeta toxin RuvB_N PF05496.12 EDO08455.1 - 3e-05 23.8 0.1 0.22 11.2 0.0 4.0 4 0 0 4 4 3 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EDO08455.1 - 5.3e-05 23.6 0.2 0.29 11.5 0.0 3.5 3 0 0 3 3 3 1 RNA helicase IstB_IS21 PF01695.17 EDO08455.1 - 7.4e-05 22.6 0.3 0.41 10.4 0.0 2.9 3 0 0 3 3 3 2 IstB-like ATP binding protein DNA_pol3_delta2 PF13177.6 EDO08455.1 - 9.3e-05 22.3 0.5 0.89 9.3 0.1 3.5 3 1 1 4 4 3 2 DNA polymerase III, delta subunit AAA_14 PF13173.6 EDO08455.1 - 0.00032 20.7 0.1 1.3 9.1 0.0 3.2 3 1 0 3 3 2 2 AAA domain AAA_24 PF13479.6 EDO08455.1 - 0.00035 20.4 0.0 0.41 10.4 0.0 3.5 3 1 0 4 4 4 1 AAA domain ABC_tran PF00005.27 EDO08455.1 - 0.00096 19.7 0.2 0.48 10.9 0.0 2.8 2 0 0 2 2 2 1 ABC transporter NACHT PF05729.12 EDO08455.1 - 0.0013 18.7 0.0 0.021 14.7 0.0 2.8 3 0 0 3 3 2 1 NACHT domain AAA_30 PF13604.6 EDO08455.1 - 0.0017 18.1 0.0 0.51 10.0 0.1 3.4 2 2 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EDO08455.1 - 0.0017 18.7 0.1 0.97 9.8 0.0 3.8 5 0 0 5 5 3 1 AAA domain AAA_3 PF07726.11 EDO08455.1 - 0.0032 17.3 0.4 0.78 9.6 0.1 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 EDO08455.1 - 0.011 15.7 1.0 3.5 7.5 0.0 3.6 4 0 0 4 4 3 0 NTPase RsgA_GTPase PF03193.16 EDO08455.1 - 0.015 15.2 0.0 6.6 6.6 0.0 2.9 2 0 0 2 2 2 0 RsgA GTPase AAA_25 PF13481.6 EDO08455.1 - 0.017 14.7 0.3 1.4 8.5 0.0 2.9 3 0 0 3 3 2 0 AAA domain Torsin PF06309.11 EDO08455.1 - 0.026 14.6 0.0 0.12 12.5 0.0 2.1 2 0 0 2 2 1 0 Torsin AAA_10 PF12846.7 EDO08455.1 - 0.026 13.5 0.5 2.9 6.7 0.0 3.2 2 1 1 3 3 3 0 AAA-like domain Rad17 PF03215.15 EDO08455.1 - 0.028 14.3 0.0 0.37 10.7 0.0 2.6 2 0 0 2 2 2 0 Rad17 P-loop domain Roc PF08477.13 EDO08455.1 - 0.034 14.4 0.0 18 5.6 0.0 2.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase KTI12 PF08433.10 EDO08455.1 - 0.035 13.5 0.0 1.2 8.6 0.0 2.8 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_29 PF13555.6 EDO08455.1 - 0.05 13.4 0.0 8.9 6.1 0.0 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain ATPase_2 PF01637.18 EDO08455.1 - 0.05 13.5 9.5 0.88 9.4 0.3 4.4 2 2 0 2 2 2 0 ATPase domain predominantly from Archaea TsaE PF02367.17 EDO08455.1 - 0.13 12.3 0.0 9 6.3 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 EDO08455.1 - 2.8 8.4 5.6 13 6.2 0.1 3.5 3 2 0 3 3 3 0 AAA domain PPR PF01535.20 EDO08456.1 - 1.4e-16 59.5 18.9 0.0023 18.0 0.1 8.5 9 0 0 9 9 9 4 PPR repeat PPR_2 PF13041.6 EDO08456.1 - 1.2e-09 38.2 23.9 0.071 13.3 0.0 7.9 4 2 5 9 9 9 4 PPR repeat family TPR_14 PF13428.6 EDO08456.1 - 2.8e-08 33.9 1.2 0.52 11.3 0.1 5.9 5 2 1 6 6 6 1 Tetratricopeptide repeat PPR_long PF17177.4 EDO08456.1 - 1.1e-06 28.2 13.4 0.064 12.6 1.0 4.2 1 1 2 4 4 4 3 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 EDO08456.1 - 5.7e-05 23.1 17.6 0.14 12.3 0.7 6.7 3 1 4 7 7 7 2 Pentatricopeptide repeat domain RPM2 PF08579.11 EDO08456.1 - 0.00022 21.6 8.0 0.0087 16.5 1.3 3.2 2 1 1 4 4 4 2 Mitochondrial ribonuclease P subunit (RPM2) Clathrin PF00637.20 EDO08456.1 - 0.00027 20.9 15.8 0.0056 16.6 5.8 3.6 1 1 2 3 3 3 2 Region in Clathrin and VPS TPR_7 PF13176.6 EDO08456.1 - 0.00028 20.7 6.6 2 8.6 0.0 6.2 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDO08456.1 - 0.00038 20.9 8.1 1.1 9.8 0.1 4.5 4 1 1 5 5 5 2 Tetratricopeptide repeat BTAD PF03704.17 EDO08456.1 - 0.00042 20.8 2.1 0.04 14.4 0.0 3.8 3 2 0 3 3 3 1 Bacterial transcriptional activator domain TPR_15 PF13429.6 EDO08456.1 - 0.0029 16.9 5.6 0.018 14.3 3.6 2.7 1 1 2 3 3 3 1 Tetratricopeptide repeat PPR_1 PF12854.7 EDO08456.1 - 0.043 13.5 4.3 8.9 6.1 0.0 4.2 6 0 0 6 6 6 0 PPR repeat ATP13 PF12921.7 EDO08456.1 - 0.05 13.5 1.3 8.3 6.3 0.1 3.1 3 0 0 3 3 3 0 Mitochondrial ATPase expression TPR_2 PF07719.17 EDO08456.1 - 0.075 13.2 16.4 9.3 6.6 0.2 6.6 6 1 1 7 7 7 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO08456.1 - 2.1 8.6 16.7 0.22 11.8 1.0 4.8 3 1 3 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EDO08456.1 - 5 7.5 12.5 41 4.5 0.2 5.5 5 2 1 6 6 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 EDO08456.1 - 7.9 7.0 8.9 31 5.1 0.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat FeS_assembly_P PF01883.19 EDO08457.1 - 1.2e-10 41.4 0.0 2.3e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein TPT PF03151.16 EDO08458.1 - 3.7e-13 49.5 17.4 4.8e-13 49.1 17.4 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EDO08458.1 - 0.0014 18.8 23.9 0.028 14.6 10.9 2.6 2 1 0 2 2 2 2 EamA-like transporter family Ubie_methyltran PF01209.18 EDO08459.1 - 4.9e-73 245.3 0.1 1.1e-72 244.2 0.1 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EDO08459.1 - 2.9e-16 59.9 0.0 3.8e-14 53.2 0.0 3.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDO08459.1 - 1.5e-15 57.6 0.0 5e-15 55.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDO08459.1 - 1.9e-11 44.0 0.0 5e-11 42.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDO08459.1 - 2e-09 38.1 0.0 5e-09 36.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDO08459.1 - 1.3e-08 34.9 0.0 2e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EDO08459.1 - 0.00012 22.0 0.0 0.00058 19.8 0.0 2.0 2 0 0 2 2 2 1 Hypothetical methyltransferase Peptidase_C78 PF07910.13 EDO08460.1 - 1.6e-43 148.7 0.6 2.3e-43 148.1 0.6 1.2 1 0 0 1 1 1 1 Peptidase family C78 Peptidase_C54 PF03416.19 EDO08460.1 - 0.0026 17.3 0.0 0.0056 16.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase family C54 UPF0020 PF01170.18 EDO08461.1 - 2e-09 37.4 0.0 1e-08 35.1 0.0 1.9 2 0 0 2 2 2 1 Putative RNA methylase family UPF0020 DUF4205 PF13898.6 EDO08462.1 - 3.5e-53 180.8 0.0 4.1e-52 177.2 0.0 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4205) NLE PF08154.12 EDO08463.1 - 1.7e-11 44.5 0.1 3.6e-11 43.4 0.1 1.6 1 0 0 1 1 1 1 NLE (NUC135) domain ANAPC4_WD40 PF12894.7 EDO08463.1 - 2.9e-07 30.7 0.0 0.0018 18.6 0.0 3.2 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO08463.1 - 3.4e-07 30.8 0.3 0.063 14.2 0.0 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat WD40_like PF17005.5 EDO08463.1 - 0.00053 19.4 0.0 0.001 18.4 0.0 1.7 1 1 0 1 1 1 1 WD40-like domain BBS2_Mid PF14783.6 EDO08463.1 - 0.014 15.4 0.0 0.37 10.8 0.0 2.8 3 1 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Nucleoporin_N PF08801.11 EDO08463.1 - 0.059 12.1 0.1 0.29 9.8 0.1 1.9 1 1 0 1 1 1 0 Nup133 N terminal like SET PF00856.28 EDO08464.1 - 3.7e-21 76.2 0.7 1.3e-20 74.4 0.7 2.0 1 1 0 1 1 1 1 SET domain DNA_pol_B_exo1 PF03104.19 EDO08465.1 - 7.4e-53 179.8 0.3 3.4e-52 177.7 0.0 2.1 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DUF1744 PF08490.12 EDO08465.1 - 3.8e-16 58.7 0.0 8.1e-16 57.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B PF00136.21 EDO08465.1 - 1e-09 37.6 1.5 1e-05 24.5 0.0 4.1 4 0 0 4 4 4 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 EDO08465.1 - 1e-06 28.6 0.1 0.00014 21.6 0.0 2.4 2 0 0 2 2 2 2 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 EDO08465.1 - 0.00049 20.1 0.0 0.0019 18.2 0.0 2.0 1 0 0 1 1 1 1 RNase_H superfamily PGK PF00162.19 EDO08465.1 - 0.00078 18.5 0.0 0.0014 17.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoglycerate kinase DUF4376 PF14301.6 EDO08466.1 - 0.11 12.8 0.1 0.17 12.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4376) CPW_WPC PF09717.10 EDO08467.1 - 3.4e-32 111.2 8.6 1e-16 61.6 3.6 2.4 2 0 0 2 2 2 2 Plasmodium falciparum domain of unknown function (CPW_WPC) Pkinase PF00069.25 EDO08469.1 - 3.7e-73 246.1 0.0 4.4e-73 245.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO08469.1 - 9.8e-36 123.4 0.0 1.1e-35 123.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO08469.1 - 3e-10 39.9 0.0 9.4e-10 38.3 0.0 1.7 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 EDO08469.1 - 0.00056 19.3 0.4 0.0012 18.3 0.4 1.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDO08469.1 - 0.00061 19.8 0.1 0.1 12.5 0.1 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family DUF2805 PF10985.8 EDO08469.1 - 0.00083 19.7 0.0 0.0014 18.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2805) RIO1 PF01163.22 EDO08469.1 - 0.057 13.0 0.9 0.1 12.1 0.9 1.4 1 1 0 1 1 1 0 RIO1 family Choline_kinase PF01633.20 EDO08469.1 - 0.11 12.0 0.2 0.18 11.3 0.2 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase DEAD PF00270.29 EDO08470.1 - 4.3e-45 153.6 0.1 1.7e-44 151.7 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO08470.1 - 1.6e-21 76.7 0.0 4.5e-21 75.3 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EDO08470.1 - 7.4e-18 64.5 0.3 1.5e-17 63.5 0.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EDO08470.1 - 3.7e-06 27.0 0.0 7.4e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit NACHT PF05729.12 EDO08470.1 - 0.073 13.0 0.0 0.15 12.0 0.0 1.6 1 1 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 EDO08470.1 - 0.09 13.0 0.9 0.38 11.0 0.0 2.4 3 0 0 3 3 3 0 AAA domain OCRE PF17780.1 EDO08471.1 - 5.3e-12 45.6 0.2 3.3e-11 43.0 0.2 2.5 1 0 0 1 1 1 1 OCRE domain zf-RanBP PF00641.18 EDO08471.1 - 2.1e-07 30.1 0.9 2.1e-07 30.1 0.9 2.0 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others Vps36-NZF-N PF16988.5 EDO08471.1 - 0.067 12.6 0.6 0.25 10.7 0.6 2.0 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Tfb4 PF03850.14 EDO08472.1 - 3.5e-16 59.5 0.9 4.7e-16 59.1 0.9 1.1 1 0 0 1 1 1 1 Transcription factor Tfb4 BLOC1_2 PF10046.9 EDO08472.1 - 0.022 15.0 0.7 0.042 14.1 0.7 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ER_lumen_recept PF00810.18 EDO08473.1 - 1.6e-48 165.3 13.9 2.6e-48 164.6 13.9 1.3 1 0 0 1 1 1 1 ER lumen protein retaining receptor Hydrolase_4 PF12146.8 EDO08474.1 - 0.16 11.2 0.0 1.1 8.5 0.0 2.1 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Romo1 PF10247.9 EDO08475.1 - 6.8e-18 64.8 13.7 9.1e-18 64.4 13.7 1.2 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Proteasome PF00227.26 EDO08476.1 - 3.5e-54 183.2 0.0 4.6e-54 182.8 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDO08476.1 - 7.4e-13 47.9 0.4 1.3e-12 47.1 0.4 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Proteasome PF00227.26 EDO08477.1 - 2.1e-56 190.4 0.5 2.8e-56 190.0 0.5 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDO08477.1 - 4.5e-13 48.6 0.0 9.5e-13 47.6 0.0 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature FtsJ PF01728.19 EDO08478.1 - 6.5e-57 192.5 0.0 1.5e-56 191.3 0.0 1.7 1 0 0 1 1 1 1 FtsJ-like methyltransferase Spb1_C PF07780.12 EDO08478.1 - 2e-38 132.2 24.1 2e-38 132.2 24.1 3.2 2 1 0 2 2 2 1 Spb1 C-terminal domain DUF3381 PF11861.8 EDO08478.1 - 1.5e-34 119.1 3.3 1.5e-34 119.1 3.3 4.4 3 2 1 4 4 4 1 Domain of unknown function (DUF3381) ATP-synt_C PF00137.21 EDO08479.1 - 8.1e-28 96.5 28.4 2.7e-15 56.5 9.9 2.1 2 0 0 2 2 2 2 ATP synthase subunit C DUF2150 PF09920.9 EDO08480.1 - 0.0015 18.5 0.5 0.0026 17.8 0.5 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2150) Taxilin PF09728.9 EDO08480.1 - 0.038 13.2 1.9 0.056 12.6 1.9 1.2 1 0 0 1 1 1 0 Myosin-like coiled-coil protein TACC_C PF05010.14 EDO08480.1 - 0.049 13.4 1.9 0.064 13.0 0.7 1.7 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal U3_assoc_6 PF08640.11 EDO08480.1 - 0.072 13.2 0.3 0.19 11.8 0.2 1.8 1 1 1 2 2 2 0 U3 small nucleolar RNA-associated protein 6 DUF812 PF05667.11 EDO08480.1 - 0.093 11.6 6.3 0.018 14.0 2.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF812) Glyco_hydro_56 PF01630.18 EDO08480.1 - 0.1 11.6 0.1 0.18 10.8 0.1 1.3 1 0 0 1 1 1 0 Hyaluronidase GIT_CC PF16559.5 EDO08480.1 - 4.9 7.1 7.9 3.2 7.7 0.9 3.1 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor FoP_duplication PF13865.6 EDO08482.1 - 0.073 13.6 1.0 0.14 12.8 1.0 1.4 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 S10_plectin PF03501.15 EDO08483.1 - 3.6e-40 135.9 0.1 4.4e-40 135.6 0.1 1.1 1 0 0 1 1 1 1 Plectin/S10 domain Methyltransf_10 PF05971.12 EDO08484.1 - 5.3e-59 200.0 3.7 2.5e-44 151.8 0.2 4.5 3 1 0 3 3 3 3 RNA methyltransferase MTS PF05175.14 EDO08484.1 - 3.4e-08 33.2 0.0 6.7e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EDO08484.1 - 2.6e-06 27.1 0.0 4.6e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 EDO08484.1 - 0.012 15.6 0.0 0.027 14.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain RRM_1 PF00076.22 EDO08485.1 - 2.6e-21 75.2 2.0 2.1e-19 69.1 0.3 3.2 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO08485.1 - 7.9e-06 25.9 0.3 0.024 14.7 0.0 3.1 2 2 0 2 2 2 2 RNA recognition motif ERM PF00769.19 EDO08486.1 - 0.00031 20.6 18.7 0.00031 20.6 18.7 2.2 1 1 1 2 2 2 1 Ezrin/radixin/moesin family FPP PF05911.11 EDO08486.1 - 0.00054 18.3 21.0 0.00054 18.3 21.0 2.5 1 1 2 3 3 3 2 Filament-like plant protein, long coiled-coil DUF1664 PF07889.12 EDO08486.1 - 0.00057 19.9 32.1 0.009 16.1 6.2 4.0 1 1 4 5 5 5 3 Protein of unknown function (DUF1664) TolA_bind_tri PF16331.5 EDO08486.1 - 0.0014 18.7 2.2 0.0014 18.7 2.2 4.1 3 1 1 4 4 4 1 TolA binding protein trimerisation DUF4164 PF13747.6 EDO08486.1 - 0.0043 17.3 7.3 0.0043 17.3 7.3 3.3 1 1 2 3 3 3 1 Domain of unknown function (DUF4164) PI3K_P85_iSH2 PF16454.5 EDO08486.1 - 0.008 15.8 4.3 0.008 15.8 4.3 3.8 1 1 0 2 2 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain GPS2_interact PF15784.5 EDO08486.1 - 0.0094 16.4 6.5 0.0094 16.4 6.5 3.0 2 1 1 3 3 3 1 G-protein pathway suppressor 2-interacting domain DUF2745 PF10922.8 EDO08486.1 - 0.028 14.7 0.4 1.4 9.3 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2745) Helicase_Sgs1 PF11408.8 EDO08486.1 - 0.16 12.0 4.1 9.2 6.4 1.4 3.3 2 1 0 2 2 2 0 Sgs1 RecQ helicase DUF3037 PF11236.8 EDO08486.1 - 0.46 10.9 8.1 1.1 9.6 0.8 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF3037) FlgM PF04316.13 EDO08486.1 - 0.52 10.7 5.4 1.6 9.2 2.1 3.0 2 0 0 2 2 2 0 Anti-sigma-28 factor, FlgM APG6_N PF17675.1 EDO08486.1 - 0.72 10.4 41.0 0.34 11.4 18.9 4.1 1 1 3 4 4 4 0 Apg6 coiled-coil region DUF745 PF05335.13 EDO08486.1 - 0.77 9.4 22.7 0.62 9.8 6.3 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF745) DUF4226 PF10774.9 EDO08486.1 - 1.7 9.0 9.1 4.9 7.5 0.3 3.5 2 1 1 4 4 4 0 Domain of unknown function (DUF4226) GAS PF13851.6 EDO08486.1 - 1.9 7.8 44.6 0.059 12.7 15.3 3.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding TPR_MLP1_2 PF07926.12 EDO08486.1 - 2.3 8.3 34.7 0.71 9.9 13.3 4.0 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein LPP PF04728.13 EDO08486.1 - 3.5 8.1 12.7 11 6.5 0.5 4.1 3 1 1 4 4 4 0 Lipoprotein leucine-zipper DUF2968 PF11180.8 EDO08486.1 - 4.1 7.0 21.3 0.48 10.0 6.9 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF2968) TMF_TATA_bd PF12325.8 EDO08486.1 - 7.3 6.8 38.4 0.054 13.7 8.8 4.4 1 1 3 4 4 4 0 TATA element modulatory factor 1 TATA binding Laminin_II PF06009.12 EDO08486.1 - 7.9 6.5 28.2 0.48 10.5 8.2 3.7 1 1 3 4 4 4 0 Laminin Domain II FlaC_arch PF05377.11 EDO08486.1 - 8.5 6.9 33.2 2.4 8.6 1.5 5.6 1 1 3 5 5 5 0 Flagella accessory protein C (FlaC) DUF3019 PF11456.8 EDO08486.1 - 9.6 6.8 12.5 0.18 12.3 2.8 2.8 2 1 0 3 3 3 0 Protein of unknown function (DUF3019) RsfS PF02410.15 EDO08490.1 - 2e-10 41.0 0.1 3.6e-10 40.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation Ribosomal_S7e PF01251.18 EDO08491.1 - 2.3e-67 226.3 5.5 2.7e-67 226.1 5.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e FCH PF00611.23 EDO08492.1 - 0.00094 19.4 0.0 0.0024 18.1 0.0 1.7 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain Goodbye PF17109.5 EDO08492.1 - 0.0044 17.5 0.0 0.014 15.8 0.0 1.8 2 0 0 2 2 2 1 fungal STAND N-terminal Goodbye domain DnaJ PF00226.31 EDO08493.1 - 0.0011 19.1 0.0 0.0021 18.2 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain Ribosomal_L21p PF00829.21 EDO08494.1 - 4.9e-13 49.2 0.0 4.9e-13 49.2 0.0 1.8 2 1 0 2 2 2 1 Ribosomal prokaryotic L21 protein RIO1 PF01163.22 EDO08495.1 - 2.5e-44 151.1 0.1 4.3e-44 150.4 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 EDO08495.1 - 6e-30 103.3 0.1 8.4e-29 99.6 0.1 2.3 2 0 0 2 2 2 1 Rio2, N-terminal APH PF01636.23 EDO08495.1 - 3.6e-08 33.6 1.1 5.7e-05 23.1 0.4 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EDO08495.1 - 8.5e-06 25.3 0.1 0.0078 15.6 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family HTH_45 PF14947.6 EDO08495.1 - 0.19 11.7 0.8 6.9 6.7 0.0 3.1 4 0 0 4 4 4 0 Winged helix-turn-helix DNA_pol_phi PF04931.13 EDO08495.1 - 0.35 8.9 5.7 0.46 8.5 5.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi SDA1 PF05285.12 EDO08495.1 - 0.97 8.8 10.9 1.4 8.3 10.9 1.1 1 0 0 1 1 1 0 SDA1 PNRC PF15365.6 EDO08496.1 - 0.037 13.9 1.5 0.092 12.6 1.5 1.7 1 0 0 1 1 1 0 Proline-rich nuclear receptor coactivator motif UPF0160 PF03690.13 EDO08497.1 - 6.4e-104 348.0 0.0 7.2e-104 347.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) DUF3450 PF11932.8 EDO08497.1 - 0.025 13.9 0.0 0.037 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Rad1 PF02144.16 EDO08498.1 - 1.4e-05 24.3 0.2 0.0055 15.8 0.0 2.2 1 1 1 2 2 2 2 Repair protein Rad1/Rec1/Rad17 Peptidase_M22 PF00814.25 EDO08499.1 - 7.4e-46 157.0 0.0 1.7e-45 155.8 0.0 1.5 1 1 0 1 1 1 1 Glycoprotease family Ribosomal_S10 PF00338.22 EDO08500.1 - 1.1e-32 112.2 0.0 2e-32 111.3 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e ABC_tran PF00005.27 EDO08501.1 - 7.2e-35 120.5 0.0 1.5e-18 67.6 0.0 2.5 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EDO08501.1 - 8.5e-13 48.8 10.0 0.0026 17.6 0.0 4.2 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDO08501.1 - 1.3e-11 44.4 0.1 0.0018 17.7 0.0 3.3 2 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain RLI PF04068.15 EDO08501.1 - 5.7e-11 42.0 6.3 1.3e-10 40.9 6.3 1.7 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Fer4 PF00037.27 EDO08501.1 - 5.4e-08 32.3 3.0 5.4e-08 32.3 3.0 2.3 3 0 0 3 3 2 1 4Fe-4S binding domain AAA_15 PF13175.6 EDO08501.1 - 1.2e-06 28.5 0.0 0.029 14.1 0.0 2.7 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EDO08501.1 - 1.4e-06 28.6 0.0 0.00076 19.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 EDO08501.1 - 2.8e-06 27.4 0.0 0.058 13.3 0.0 2.4 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_16 PF13191.6 EDO08501.1 - 1.4e-05 25.6 0.0 0.036 14.4 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain Fer4_6 PF12837.7 EDO08501.1 - 4.6e-05 23.3 2.4 4.6e-05 23.3 2.4 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain RsgA_GTPase PF03193.16 EDO08501.1 - 5e-05 23.3 0.0 0.31 10.9 0.0 3.2 3 0 0 3 3 3 2 RsgA GTPase AAA_29 PF13555.6 EDO08501.1 - 0.00014 21.5 0.9 0.43 10.4 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EDO08501.1 - 0.00021 21.8 0.2 0.074 13.5 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EDO08501.1 - 0.00042 20.7 0.0 0.42 11.0 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EDO08501.1 - 0.00087 19.2 1.7 0.064 13.2 0.0 2.7 3 0 0 3 3 2 1 NACHT domain Fer4_21 PF14697.6 EDO08501.1 - 0.00091 19.3 13.1 0.0018 18.4 13.1 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 EDO08501.1 - 0.0017 18.9 1.2 0.0017 18.9 1.2 2.7 2 1 2 4 4 3 2 4Fe-4S dicluster domain AAA_5 PF07728.14 EDO08501.1 - 0.0018 18.3 0.3 1.8 8.6 0.1 3.5 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EDO08501.1 - 0.0019 18.0 0.5 0.32 10.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain Fer4_2 PF12797.7 EDO08501.1 - 0.0026 17.8 0.9 0.0026 17.8 0.9 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain RNA_helicase PF00910.22 EDO08501.1 - 0.0028 18.0 0.0 1.6 9.2 0.0 2.7 2 0 0 2 2 2 1 RNA helicase Fer4_10 PF13237.6 EDO08501.1 - 0.0049 16.9 1.4 0.0049 16.9 1.4 2.4 1 1 1 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 EDO08501.1 - 0.0052 16.9 13.2 0.011 15.8 13.2 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain SRP54 PF00448.22 EDO08501.1 - 0.0082 15.8 4.1 0.14 11.8 0.1 2.8 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain AAA_18 PF13238.6 EDO08501.1 - 0.012 16.1 0.0 0.78 10.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EDO08501.1 - 0.014 15.1 0.4 0.59 9.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EDO08501.1 - 0.017 15.3 0.0 2.5 8.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EDO08501.1 - 0.021 14.0 0.0 0.99 8.5 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain Thymidylate_kin PF02223.17 EDO08501.1 - 0.024 14.3 1.1 9.1 5.9 0.0 3.2 3 0 0 3 3 3 0 Thymidylate kinase TsaE PF02367.17 EDO08501.1 - 0.029 14.4 0.3 0.31 11.0 0.1 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Piwi PF02171.17 EDO08501.1 - 0.038 13.2 0.0 0.091 12.0 0.0 1.6 2 0 0 2 2 2 0 Piwi domain Fer4_16 PF13484.6 EDO08501.1 - 0.04 14.9 0.9 0.04 14.9 0.9 2.5 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain AAA_7 PF12775.7 EDO08501.1 - 0.042 13.4 0.3 0.68 9.4 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region VirE PF05272.11 EDO08501.1 - 0.051 13.3 0.0 9.3 5.9 0.0 2.5 2 0 0 2 2 2 0 Virulence-associated protein E Septin PF00735.18 EDO08501.1 - 0.053 12.8 0.0 1.9 7.7 0.0 2.9 3 0 0 3 3 3 0 Septin AAA_28 PF13521.6 EDO08501.1 - 0.073 13.3 0.1 12 6.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EDO08501.1 - 0.075 12.4 1.4 0.15 11.4 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI MMR_HSR1 PF01926.23 EDO08501.1 - 0.083 13.0 0.1 22 5.2 0.0 2.7 2 1 0 2 2 2 0 50S ribosome-binding GTPase G-alpha PF00503.20 EDO08501.1 - 0.1 11.7 0.0 7.6 5.6 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit TniB PF05621.11 EDO08501.1 - 0.11 11.9 0.0 1.1 8.6 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein MobB PF03205.14 EDO08501.1 - 0.32 10.9 1.6 1.9 8.4 0.1 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B NTPase_1 PF03266.15 EDO08501.1 - 0.69 9.8 3.7 5.6 6.8 0.0 2.9 3 0 0 3 3 2 0 NTPase Fer4_8 PF13183.6 EDO08501.1 - 3.5 8.1 11.1 0.42 11.1 1.4 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_4 PF12800.7 EDO08501.1 - 4.5 8.0 14.6 0.29 11.8 2.9 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain RRP36 PF06102.12 EDO08502.1 - 1.9e-28 99.5 13.7 1.9e-28 99.5 13.7 1.6 2 0 0 2 2 2 1 rRNA biogenesis protein RRP36 Rpp20 PF12328.8 EDO08502.1 - 0.0069 16.3 2.8 0.0069 16.3 2.8 2.2 1 1 1 2 2 2 1 Rpp20 subunit of nuclear RNase MRP and P RAP PF08373.10 EDO08504.1 - 1.1e-23 83.0 0.1 2.8e-23 81.8 0.1 1.7 1 0 0 1 1 1 1 RAP domain MTES_1575 PF18741.1 EDO08504.1 - 0.00033 20.8 0.1 0.0011 19.1 0.0 1.9 2 0 0 2 2 2 1 REase_MTES_1575 MMtag PF10159.9 EDO08504.1 - 0.045 14.0 0.6 0.045 14.0 0.6 2.4 2 1 1 3 3 3 0 Multiple myeloma tumor-associated Glyco_tranf_2_4 PF13704.6 EDO08504.1 - 0.088 13.3 0.8 0.16 12.5 0.2 1.7 2 0 0 2 2 2 0 Glycosyl transferase family 2 DUF2407_C PF13373.6 EDO08504.1 - 2.6 8.2 7.3 0.13 12.4 1.4 1.7 2 0 0 2 2 2 0 DUF2407 C-terminal domain Fer4_24 PF18109.1 EDO08505.1 - 0.0021 18.3 0.1 0.064 13.6 0.0 2.7 3 0 0 3 3 3 1 Ferredoxin I 4Fe-4S cluster domain BBP1_C PF15272.6 EDO08505.1 - 0.0025 17.7 6.1 0.0068 16.3 0.1 2.2 2 0 0 2 2 2 1 Spindle pole body component BBP1, C-terminal ATG16 PF08614.11 EDO08505.1 - 0.0025 18.1 9.4 0.018 15.3 9.2 1.9 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) MscS_porin PF12795.7 EDO08505.1 - 0.0032 17.1 6.4 0.2 11.1 0.1 2.1 2 0 0 2 2 2 2 Mechanosensitive ion channel porin domain PI3K_P85_iSH2 PF16454.5 EDO08505.1 - 0.0038 16.8 4.8 0.0038 16.8 4.8 2.0 2 0 0 2 2 2 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Chloroplast_duf PF14476.6 EDO08505.1 - 0.012 14.7 0.3 0.013 14.5 0.3 1.2 1 0 0 1 1 1 0 Petal formation-expressed SOAR PF16533.5 EDO08505.1 - 0.018 15.0 7.6 0.66 10.0 2.3 2.2 2 0 0 2 2 2 0 STIM1 Orai1-activating region Trans_reg_C PF00486.28 EDO08505.1 - 0.03 14.4 0.6 0.057 13.5 0.2 1.7 2 0 0 2 2 2 0 Transcriptional regulatory protein, C terminal CorA PF01544.18 EDO08505.1 - 0.036 13.4 2.5 0.045 13.1 2.5 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Spc7 PF08317.11 EDO08505.1 - 0.076 11.9 10.1 0.12 11.2 4.0 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein ApoLp-III PF07464.11 EDO08505.1 - 0.089 12.9 6.9 0.42 10.7 1.2 2.4 2 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) IFT57 PF10498.9 EDO08505.1 - 0.09 11.7 10.4 0.12 11.4 0.7 2.1 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Syntaxin-6_N PF09177.11 EDO08505.1 - 0.1 13.2 6.2 0.08 13.5 2.0 2.5 1 1 1 2 2 2 0 Syntaxin 6, N-terminal FtsX_ECD PF18075.1 EDO08505.1 - 0.12 13.0 3.4 0.72 10.5 0.2 2.9 2 2 1 3 3 3 0 FtsX extracellular domain Bestrophin PF01062.21 EDO08505.1 - 0.15 11.5 0.9 0.18 11.1 0.9 1.2 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel TMPIT PF07851.13 EDO08505.1 - 0.31 10.3 9.8 0.34 10.1 1.6 2.0 1 1 1 2 2 2 0 TMPIT-like protein TetR_C_23 PF17931.1 EDO08505.1 - 0.46 10.6 3.9 1.7 8.8 0.2 2.1 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF2203 PF09969.9 EDO08505.1 - 0.63 10.8 5.5 14 6.4 1.4 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) SRI PF08236.11 EDO08505.1 - 0.69 10.1 6.7 0.13 12.5 2.0 2.0 1 1 1 2 2 2 0 SRI (Set2 Rpb1 interacting) domain ING PF12998.7 EDO08505.1 - 1 10.0 6.8 8.9 7.0 6.8 2.0 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding YgaB PF14182.6 EDO08505.1 - 1.5 9.2 11.0 4.1 7.9 3.4 2.9 2 1 1 3 3 3 0 YgaB-like protein FlaC_arch PF05377.11 EDO08505.1 - 1.9 9.0 9.8 23 5.4 1.2 3.6 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 EDO08505.1 - 2.7 8.1 7.3 2.3 8.3 1.6 2.4 2 2 0 2 2 2 0 Protein of unknown function (DUF1664) SRP68 PF16969.5 EDO08506.1 - 2.9e-33 115.7 3.8 6.3e-32 111.3 1.7 2.4 2 1 0 2 2 2 2 RNA-binding signal recognition particle 68 NAC PF01849.18 EDO08507.1 - 5.2e-21 74.4 0.2 9.8e-21 73.5 0.2 1.5 1 0 0 1 1 1 1 NAC domain DUF4239 PF14023.6 EDO08508.1 - 0.19 11.4 5.2 0.045 13.5 1.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) HAND PF09110.11 EDO08508.1 - 3 8.6 7.7 8.4 7.2 0.0 2.5 2 1 1 3 3 3 0 HAND Methyltrans_RNA PF04452.14 EDO08509.1 - 1.6e-39 135.6 0.0 1.9e-39 135.4 0.0 1.0 1 0 0 1 1 1 1 RNA methyltransferase FAST_1 PF06743.15 EDO08510.1 - 4.3e-10 39.4 4.9 0.39 10.7 0.1 7.3 5 2 3 8 8 8 4 FAST kinase-like protein, subdomain 1 HPPK PF01288.20 EDO08510.1 - 0.0031 18.0 0.3 1.7 9.2 0.1 4.2 4 0 0 4 4 4 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) Med12 PF09497.10 EDO08511.1 - 0.076 13.3 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 Transcription mediator complex subunit Med12 HEAT_2 PF13646.6 EDO08512.1 - 0.00023 21.5 0.3 6.9 7.1 0.0 5.0 4 0 0 4 4 4 1 HEAT repeats HEAT PF02985.22 EDO08512.1 - 0.00042 20.3 6.0 0.83 10.1 0.0 5.4 5 0 0 5 5 5 2 HEAT repeat HEAT_PBS PF03130.16 EDO08512.1 - 0.064 14.0 0.9 17 6.5 0.0 3.8 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat SWC7 PF17330.2 EDO08512.1 - 0.082 13.0 0.4 0.47 10.5 0.0 2.5 2 1 0 2 2 2 0 SWR1 chromatin-remodelling complex, sub-unit Swc7 MCM_N PF14551.6 EDO08512.1 - 0.24 12.0 0.4 17 6.0 0.1 2.6 2 0 0 2 2 2 0 MCM N-terminal domain Vac14_Fab1_bd PF12755.7 EDO08512.1 - 0.26 11.9 1.1 4.6 7.9 0.1 3.5 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EDO08512.1 - 0.47 11.0 3.0 27 5.4 0.0 4.3 4 0 0 4 4 4 0 HEAT-like repeat Arm PF00514.23 EDO08512.1 - 4.2 7.6 4.7 49 4.2 0.0 4.3 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat HTH_Tnp_1_2 PF13022.6 EDO08513.1 - 0.16 12.2 0.0 0.23 11.6 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix of insertion element transposase HEPN_Swt1 PF18731.1 EDO08514.1 - 0.0068 16.7 0.0 0.015 15.6 0.0 1.5 1 0 0 1 1 1 1 Swt1-like HEPN tRNA_synthFbeta PF17759.1 EDO08515.1 - 4e-30 104.9 0.0 5.8e-30 104.3 0.0 1.2 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 EDO08515.1 - 5.8e-22 77.7 0.2 1.1e-21 76.8 0.2 1.5 1 0 0 1 1 1 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 EDO08515.1 - 2.8e-17 62.9 0.0 4.3e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 EDO08515.1 - 3.5e-12 46.4 0.0 4.4e-09 36.5 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetase B5 domain AP2 PF00847.20 EDO08516.1 - 3.9e-12 46.2 0.5 6.6e-12 45.5 0.5 1.4 1 0 0 1 1 1 1 AP2 domain PPTA PF01239.22 EDO08517.1 - 2.1e-21 74.9 5.9 7.3e-06 25.5 0.1 5.6 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat Sec7 PF01369.20 EDO08518.1 - 2.6e-64 216.3 0.6 7e-64 214.9 0.6 1.8 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 EDO08518.1 - 5.3e-12 45.9 13.4 1.8e-11 44.2 5.8 3.5 2 1 0 2 2 2 2 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 EDO08518.1 - 0.0033 17.1 2.4 0.0033 17.1 2.4 2.2 2 0 0 2 2 2 1 Dimerisation and cyclophilin-binding domain of Mon2 DUF4303 PF14136.6 EDO08518.1 - 0.23 11.2 1.4 0.36 10.5 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4303) EF_TS PF00889.19 EDO08519.1 - 1.9e-06 27.7 0.1 3.3e-06 26.9 0.1 1.5 1 1 0 1 1 1 1 Elongation factor TS UBA_4 PF14555.6 EDO08519.1 - 0.0018 18.1 0.0 0.0035 17.1 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain BRCA-2_OB1 PF09103.10 EDO08519.1 - 0.051 13.5 0.5 0.23 11.4 0.5 2.1 1 1 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 PMI_typeI PF01238.21 EDO08520.1 - 7.9e-48 163.5 0.0 4.5e-46 157.7 0.0 2.3 1 1 0 1 1 1 1 Phosphomannose isomerase type I AraC_binding PF02311.19 EDO08520.1 - 0.078 12.9 0.0 0.29 11.0 0.0 1.9 2 0 0 2 2 2 0 AraC-like ligand binding domain Pkinase PF00069.25 EDO08521.1 - 1.9e-38 132.4 0.0 1e-32 113.6 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO08521.1 - 1.6e-10 40.8 0.0 2.7e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Gpi1 PF05024.15 EDO08522.1 - 4.5e-30 105.1 8.2 4.5e-30 105.1 8.2 1.5 2 0 0 2 2 2 1 N-acetylglucosaminyl transferase component (Gpi1) Amidohydro_2 PF04909.14 EDO08523.1 - 4.1e-06 26.8 0.0 5.6e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase ELFV_dehydrog PF00208.21 EDO08524.1 - 1.3e-47 162.6 0.0 2.7e-47 161.6 0.0 1.6 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 EDO08524.1 - 2.5e-19 68.4 0.0 1.8e-13 49.0 0.0 2.1 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 EDO08524.1 - 0.04 13.8 0.0 0.24 11.3 0.0 2.2 2 0 0 2 2 2 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain PgaPase_1 PF06162.12 EDO08524.1 - 0.13 12.0 0.0 0.31 10.8 0.0 1.6 1 0 0 1 1 1 0 Putative pyroglutamyl peptidase PgaPase_1 CD34_antigen PF06365.12 EDO08526.1 - 0.31 10.6 2.7 0.94 9.0 0.5 2.4 2 1 0 2 2 2 0 CD34/Podocalyxin family CD225 PF04505.12 EDO08526.1 - 0.39 10.9 0.1 0.39 10.9 0.1 3.5 3 1 1 4 4 4 0 Interferon-induced transmembrane protein DUF202 PF02656.15 EDO08526.1 - 0.5 10.9 0.1 0.5 10.9 0.1 3.9 4 1 0 4 4 4 0 Domain of unknown function (DUF202) Orf78 PF06024.12 EDO08526.1 - 2.1 8.7 3.9 3.4 8.0 0.0 2.8 3 0 0 3 3 3 0 Orf78 (ac78) DUF2157 PF09925.9 EDO08526.1 - 2.9 7.7 15.5 2.8 7.7 0.0 3.4 2 1 1 3 3 3 0 Predicted membrane protein (DUF2157) DUF4714 PF15833.5 EDO08526.1 - 6 6.8 6.6 1.1 9.3 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4714) SNF2_N PF00176.23 EDO08527.1 - 1.7e-25 89.5 0.1 3.1e-25 88.6 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDO08527.1 - 1.2e-12 48.1 0.0 4.2e-12 46.4 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO08527.1 - 1.3e-06 28.6 0.0 3e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EDO08527.1 - 0.0024 17.1 0.1 0.0047 16.2 0.1 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase S1 PF00575.23 EDO08528.1 - 4.6e-07 30.1 3.2 0.0089 16.3 0.0 2.9 3 0 0 3 3 3 2 S1 RNA binding domain Fasciclin PF02469.22 EDO08529.1 - 6e-11 42.7 0.0 8.1e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 Fasciclin domain Ribosomal_L7Ae PF01248.26 EDO08530.1 - 2.1e-26 91.5 0.2 2.8e-26 91.1 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 EDO08530.1 - 0.042 13.7 0.0 0.057 13.3 0.0 1.2 1 0 0 1 1 1 0 PELOTA RNA binding domain T3SSipB PF16535.5 EDO08530.1 - 0.088 13.3 0.2 0.12 12.8 0.2 1.1 1 0 0 1 1 1 0 Type III cell invasion protein SipB DUF2710 PF10921.8 EDO08530.1 - 0.12 12.8 0.0 0.16 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2710) S-AdoMet_synt_C PF02773.16 EDO08531.1 - 9e-58 194.2 0.0 1.6e-57 193.3 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 EDO08531.1 - 6.8e-44 149.0 0.0 1.5e-43 147.9 0.0 1.6 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 EDO08531.1 - 4e-42 142.9 0.2 7.1e-42 142.1 0.2 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain Amidase PF01425.21 EDO08532.1 - 8.3e-86 288.7 0.0 1.1e-85 288.3 0.0 1.1 1 0 0 1 1 1 1 Amidase Antigen_Bd37 PF11641.8 EDO08532.1 - 0.03 13.8 0.2 0.054 13.0 0.2 1.4 1 0 0 1 1 1 0 Glycosylphosphatidylinositol-anchored merozoite surface protein DUF4885 PF16226.5 EDO08532.1 - 0.03 13.4 0.2 0.081 12.0 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4885) zf-C3HC4 PF00097.25 EDO08533.1 - 3.2e-10 39.7 8.1 4.6e-10 39.2 8.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDO08533.1 - 4.2e-10 39.3 9.4 5.7e-10 38.9 9.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDO08533.1 - 1.8e-09 37.3 6.1 2.6e-09 36.8 6.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDO08533.1 - 4.3e-09 36.2 7.4 6.1e-09 35.7 7.4 1.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EDO08533.1 - 2.5e-08 33.8 4.3 2.5e-08 33.8 4.3 2.1 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 EDO08533.1 - 3.9e-08 33.5 11.3 5.4e-08 33.0 11.3 1.2 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EDO08533.1 - 1.1e-06 28.4 8.3 1.6e-06 27.8 8.3 1.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EDO08533.1 - 1.6e-06 28.1 8.8 2.5e-06 27.5 8.8 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EDO08533.1 - 0.00018 21.7 10.9 0.00033 20.9 10.9 1.5 1 1 0 1 1 1 1 RING-H2 zinc finger domain Rtf2 PF04641.12 EDO08533.1 - 0.00029 20.3 0.1 0.00038 19.9 0.1 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger U-box PF04564.15 EDO08533.1 - 0.072 13.3 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 U-box domain zf-ANAPC11 PF12861.7 EDO08533.1 - 0.079 13.0 6.7 0.12 12.4 6.7 1.4 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Baculo_IE-1 PF05290.11 EDO08533.1 - 0.23 11.4 4.0 0.34 10.9 4.0 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_6 PF14835.6 EDO08533.1 - 0.25 11.3 3.2 0.4 10.6 3.2 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 EDO08533.1 - 0.44 10.4 7.5 1.9 8.3 7.5 1.9 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 EDO08533.1 - 0.87 9.4 9.0 0.73 9.6 6.0 2.2 2 1 0 2 2 2 0 RING-like zinc finger IBR PF01485.21 EDO08533.1 - 1.4 9.2 9.2 8.2 6.7 9.7 1.9 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain EF-hand_7 PF13499.6 EDO08534.1 - 2e-05 24.9 0.0 0.0001 22.7 0.0 2.0 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 EDO08534.1 - 3.9e-05 23.2 0.3 0.00032 20.4 0.2 2.5 3 0 0 3 3 3 1 EF-hand domain Glycos_trans_3N PF02885.17 EDO08534.1 - 0.008 16.0 0.0 0.18 11.6 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family, helical bundle domain EF-hand_1 PF00036.32 EDO08534.1 - 0.011 15.3 0.6 0.031 13.8 0.1 2.1 2 0 0 2 2 2 0 EF hand PSCyt2 PF07583.11 EDO08534.1 - 0.012 15.6 0.0 0.55 10.1 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1549) SapB_1 PF05184.15 EDO08534.1 - 0.023 14.7 0.1 0.13 12.3 0.0 2.1 2 0 0 2 2 2 0 Saposin-like type B, region 1 DUF5370 PF17340.2 EDO08534.1 - 0.11 12.4 0.1 0.85 9.5 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5370) DUF1456 PF07308.13 EDO08534.1 - 0.17 12.3 0.0 1.3 9.4 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1456) TFIIA PF03153.13 EDO08535.1 - 7 6.5 28.8 9.6 6.1 28.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Patatin PF01734.22 EDO08536.1 - 0.00069 19.9 0.2 0.0028 17.9 0.2 2.0 1 1 0 1 1 1 1 Patatin-like phospholipase AAA PF00004.29 EDO08537.1 - 1.2e-08 35.4 0.0 3.3e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDO08537.1 - 0.0036 17.6 0.0 0.062 13.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 EDO08537.1 - 0.0039 17.0 0.0 0.034 13.9 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 EDO08537.1 - 0.0071 16.1 0.1 0.02 14.7 0.0 1.7 2 0 0 2 2 2 1 IstB-like ATP binding protein TIP49 PF06068.13 EDO08537.1 - 0.04 13.1 0.0 0.063 12.5 0.0 1.1 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_24 PF13479.6 EDO08537.1 - 0.073 12.8 0.1 11 5.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain zf-C2H2_3 PF13878.6 EDO08538.1 - 0.15 11.9 2.1 0.31 10.9 2.1 1.6 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO DUF3800 PF12686.7 EDO08539.1 - 0.22 12.1 2.5 7.2 7.3 0.1 4.0 2 2 0 2 2 2 0 Protein of unknown function (DUF3800) AcylCoA_dehyd_C PF12186.8 EDO08539.1 - 1 9.5 9.7 1.8 8.7 0.9 4.4 4 0 0 4 4 4 0 Acyl-CoA dehydrogenase C terminal LSM PF01423.22 EDO08540.1 - 0.0015 18.1 0.0 0.004 16.8 0.0 1.7 2 0 0 2 2 2 1 LSM domain WD40 PF00400.32 EDO08541.1 - 1.3e-06 29.0 0.1 0.46 11.4 0.0 5.8 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO08541.1 - 4.3e-06 26.9 0.1 0.21 11.9 0.0 3.7 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF3952 PF13130.6 EDO08541.1 - 1.3 9.3 8.1 7.5 6.8 1.4 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3952) UQ_con PF00179.26 EDO08542.1 - 6.3e-46 155.5 0.1 7.4e-46 155.3 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Hyr1 PF15789.5 EDO08542.1 - 0.042 13.4 0.1 0.088 12.4 0.1 1.5 1 0 0 1 1 1 0 Hyphally regulated cell wall GPI-anchored protein 1 RRM_1 PF00076.22 EDO08543.1 - 1.9e-06 27.6 0.0 0.015 15.1 0.0 3.0 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NRDE-2 PF08424.10 EDO08543.1 - 0.0027 16.9 0.2 12 4.9 0.0 3.4 2 2 1 3 3 3 3 NRDE-2, necessary for RNA interference Arm PF00514.23 EDO08544.1 - 3.8e-79 258.6 6.4 5.9e-14 51.5 0.0 8.4 8 0 0 8 8 8 7 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EDO08544.1 - 1.1e-23 83.2 0.0 1.1e-09 38.5 0.1 5.1 4 1 1 5 5 5 3 HEAT-like repeat HEAT_2 PF13646.6 EDO08544.1 - 3.5e-19 69.0 0.0 6.3e-07 29.7 0.0 4.5 1 1 1 3 3 3 3 HEAT repeats Arm_3 PF16186.5 EDO08544.1 - 1.4e-14 53.3 0.0 1.3e-12 47.1 0.0 2.9 3 0 0 3 3 3 1 Atypical Arm repeat HEAT PF02985.22 EDO08544.1 - 2.2e-13 49.2 0.0 0.00044 20.3 0.0 6.3 6 0 0 6 6 6 3 HEAT repeat IBB PF01749.20 EDO08544.1 - 4.5e-08 33.4 1.2 1.2e-07 32.0 0.2 2.2 2 0 0 2 2 2 1 Importin beta binding domain Arm_2 PF04826.13 EDO08544.1 - 8.2e-07 28.7 0.0 0.019 14.5 0.0 4.1 1 1 3 4 4 4 1 Armadillo-like V-ATPase_H_C PF11698.8 EDO08544.1 - 4.7e-06 26.7 0.0 0.32 11.1 0.0 3.7 3 0 0 3 3 3 2 V-ATPase subunit H NopRA1 PF16201.5 EDO08544.1 - 1.7e-05 24.5 0.0 0.0029 17.2 0.0 3.6 3 1 1 4 4 4 1 Nucleolar pre-ribosomal-associated protein 1 RICTOR_V PF14668.6 EDO08544.1 - 2.1e-05 24.7 1.4 3.9 7.8 0.0 5.5 2 2 3 6 6 6 2 Rapamycin-insensitive companion of mTOR, domain 5 Adaptin_N PF01602.20 EDO08544.1 - 3.1e-05 22.7 0.0 0.016 13.8 0.0 2.7 1 1 2 3 3 3 2 Adaptin N terminal region HEAT_PBS PF03130.16 EDO08544.1 - 0.0059 17.2 0.1 0.63 10.9 0.1 3.8 3 0 0 3 3 3 1 PBS lyase HEAT-like repeat Atx10homo_assoc PF09759.9 EDO08544.1 - 0.0073 16.3 0.0 0.34 11.0 0.0 3.1 3 1 1 4 4 4 1 Spinocerebellar ataxia type 10 protein domain NPL PF17800.1 EDO08545.1 - 2.6e-12 47.2 0.0 4.2e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 Nucleoplasmin-like domain CDC45 PF02724.14 EDO08545.1 - 0.11 10.7 1.1 0.11 10.7 1.1 1.1 1 0 0 1 1 1 0 CDC45-like protein PBP1_TM PF14812.6 EDO08545.1 - 5.5 7.4 8.2 8 6.9 8.2 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ribosomal_S17 PF00366.20 EDO08546.1 - 5.8e-14 51.9 1.9 7.4e-14 51.6 0.5 1.9 2 0 0 2 2 2 1 Ribosomal protein S17 DUF2040 PF09745.9 EDO08547.1 - 7.7e-16 58.2 4.2 1.9e-15 56.9 3.7 1.9 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 55 (DUF2040) RNA_pol_Rpb5_C PF01191.19 EDO08548.1 - 1.2e-32 111.6 0.2 2.1e-32 110.8 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 EDO08548.1 - 3.9e-21 75.4 0.7 5.3e-21 75.0 0.2 1.5 2 0 0 2 2 2 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.12 EDO08548.1 - 0.002 18.1 0.0 0.0043 17.0 0.0 1.5 1 0 0 1 1 1 1 Restriction endonuclease Sof1 PF04158.14 EDO08548.1 - 0.044 14.1 0.1 0.1 12.8 0.1 1.6 1 0 0 1 1 1 0 Sof1-like domain RC-P840_PscD PF10657.9 EDO08548.1 - 0.12 12.5 0.1 0.19 11.9 0.1 1.2 1 0 0 1 1 1 0 Photosystem P840 reaction centre protein PscD Rieske PF00355.26 EDO08549.1 - 8.6e-13 48.0 0.0 1.8e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain FXa_inhibition PF14670.6 EDO08549.1 - 0.18 12.1 2.2 0.3 11.4 2.2 1.3 1 0 0 1 1 1 0 Coagulation Factor Xa inhibitory site ODV-E18 PF10717.9 EDO08550.1 - 0.61 10.0 7.1 3.4 7.6 0.2 3.1 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 Coatomer_WDAD PF04053.14 EDO08551.1 - 6.9e-99 331.9 7.5 1.4e-98 330.9 7.5 1.5 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.32 EDO08551.1 - 1.7e-35 120.4 12.7 8.1e-09 36.0 0.0 8.0 7 0 0 7 7 7 5 WD domain, G-beta repeat COPI_C PF06957.11 EDO08551.1 - 3.8e-35 121.4 0.2 7.3e-35 120.5 0.2 1.5 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus ANAPC4_WD40 PF12894.7 EDO08551.1 - 1.9e-07 31.3 1.1 1 9.7 0.0 5.0 3 1 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDO08551.1 - 0.03 13.0 5.4 5.4 5.5 0.1 3.6 3 1 1 4 4 4 0 Nucleoporin Nup120/160 TPR_2 PF07719.17 EDO08551.1 - 0.15 12.3 0.2 7.4 6.9 0.1 3.8 5 0 0 5 5 5 0 Tetratricopeptide repeat UQ_con PF00179.26 EDO08552.1 - 2.1e-40 137.6 0.0 2.4e-40 137.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EDO08552.1 - 0.0032 17.8 0.1 0.004 17.4 0.1 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 EDO08552.1 - 0.032 13.9 0.0 0.038 13.7 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B AAA_23 PF13476.6 EDO08553.1 - 3e-26 93.2 7.2 3e-26 93.2 7.2 6.0 1 1 3 5 5 3 1 AAA domain SMC_N PF02463.19 EDO08553.1 - 2.8e-11 43.3 18.0 2.5e-07 30.4 0.2 3.7 3 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EDO08553.1 - 6.2e-10 39.4 2.6 0.00019 21.4 0.0 3.6 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EDO08553.1 - 9.5e-08 32.1 8.5 9.5e-08 32.1 8.5 4.5 1 1 1 3 3 2 2 AAA ATPase domain SbcCD_C PF13558.6 EDO08553.1 - 0.00018 21.7 0.0 0.00056 20.1 0.0 1.9 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 EDO08553.1 - 0.00085 19.0 0.0 0.0021 17.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.6 EDO08553.1 - 0.0022 16.8 15.7 0.0022 16.8 15.7 5.8 2 1 4 6 6 5 2 AAA domain IFT57 PF10498.9 EDO08553.1 - 0.0028 16.7 11.4 0.0028 16.7 11.4 5.6 3 2 2 5 5 5 2 Intra-flagellar transport protein 57 AAA_27 PF13514.6 EDO08553.1 - 0.0031 17.1 0.0 0.0031 17.1 0.0 3.6 3 1 0 3 3 3 1 AAA domain TetR_C_24 PF17932.1 EDO08553.1 - 0.017 15.4 1.7 0.31 11.3 0.0 3.7 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain AAA_22 PF13401.6 EDO08553.1 - 0.025 14.9 0.0 0.025 14.9 0.0 4.2 4 0 0 4 4 4 0 AAA domain Uteroglobin PF01099.17 EDO08553.1 - 0.035 14.4 0.7 0.035 14.4 0.7 4.6 3 1 0 4 4 3 0 Uteroglobin family AAA_16 PF13191.6 EDO08553.1 - 0.39 11.1 0.0 0.39 11.1 0.0 3.3 4 1 1 5 5 5 0 AAA ATPase domain RsgA_GTPase PF03193.16 EDO08553.1 - 0.87 9.5 0.0 0.87 9.5 0.0 4.5 4 2 1 5 5 5 0 RsgA GTPase Lactamase_B_6 PF16661.5 EDO08555.1 - 7.8e-20 71.1 0.0 1.4e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Beta-Casp PF10996.8 EDO08555.1 - 2.4e-10 40.7 0.0 5.9e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain zf-C3HC4 PF00097.25 EDO08556.1 - 7.5e-08 32.1 14.3 1.8e-07 30.9 14.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDO08556.1 - 1.7e-07 30.9 12.5 4e-07 29.8 12.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDO08556.1 - 2.6e-07 30.5 14.2 7.8e-07 29.0 14.2 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EDO08556.1 - 2.9e-07 30.3 12.6 7e-07 29.0 12.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDO08556.1 - 1e-05 25.8 13.8 3.1e-05 24.2 13.8 1.9 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EDO08556.1 - 2.4e-05 24.3 10.4 6.5e-05 22.9 10.4 1.8 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EDO08556.1 - 2.9e-05 23.8 11.6 8.2e-05 22.4 11.6 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EDO08556.1 - 0.00019 21.5 11.3 0.00042 20.4 11.3 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING DUF4407 PF14362.6 EDO08556.1 - 0.0012 18.2 14.1 0.021 14.2 6.0 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF4407) zf-RING_6 PF14835.6 EDO08556.1 - 0.0036 17.1 5.6 0.012 15.4 5.6 1.9 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 EDO08556.1 - 0.016 15.5 9.8 0.14 12.4 9.9 2.3 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.6 EDO08556.1 - 0.042 13.6 9.6 0.11 12.3 9.6 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Nup54_57_C PF18570.1 EDO08556.1 - 0.043 13.4 0.3 0.1 12.2 0.3 1.7 1 0 0 1 1 1 0 NUP57/Nup54 C-terminal domain Filament PF00038.21 EDO08556.1 - 0.046 13.3 27.4 0.88 9.1 1.0 4.0 3 1 1 4 4 4 0 Intermediate filament protein bZIP_1 PF00170.21 EDO08556.1 - 0.048 13.8 21.7 0.38 10.9 0.4 5.8 5 0 0 5 5 5 0 bZIP transcription factor Spc7 PF08317.11 EDO08556.1 - 0.11 11.3 22.0 0.026 13.4 11.9 3.2 2 1 1 3 3 3 0 Spc7 kinetochore protein GBP_C PF02841.14 EDO08556.1 - 0.12 11.8 14.0 0.071 12.5 10.9 2.1 1 1 1 2 2 2 0 Guanylate-binding protein, C-terminal domain Fez1 PF06818.15 EDO08556.1 - 0.38 11.2 27.7 4.3 7.7 6.4 3.6 1 1 0 2 2 2 0 Fez1 TMF_TATA_bd PF12325.8 EDO08556.1 - 0.39 10.9 29.3 3.2 8.0 0.8 4.6 4 1 1 5 5 4 0 TATA element modulatory factor 1 TATA binding ZapB PF06005.12 EDO08556.1 - 0.57 10.7 24.3 0.56 10.7 2.5 5.6 5 1 1 6 6 6 0 Cell division protein ZapB Uso1_p115_C PF04871.13 EDO08556.1 - 0.66 10.4 18.6 4.3 7.7 1.5 3.9 3 1 0 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region bZIP_2 PF07716.15 EDO08556.1 - 0.72 10.0 21.5 2.5 8.3 0.3 5.8 5 0 0 5 5 5 0 Basic region leucine zipper TSC22 PF01166.18 EDO08556.1 - 0.84 10.0 0.0 0.84 10.0 0.0 4.6 6 0 0 6 6 4 0 TSC-22/dip/bun family FliJ PF02050.16 EDO08556.1 - 1 9.6 23.0 4 7.7 2.5 4.5 2 1 2 4 4 4 0 Flagellar FliJ protein DivIC PF04977.15 EDO08556.1 - 1.1 9.1 17.4 7.5 6.4 0.3 5.1 5 0 0 5 5 5 0 Septum formation initiator DUF5101 PF17031.5 EDO08556.1 - 1.1 9.4 6.8 9.7 6.4 0.0 3.8 4 0 0 4 4 3 0 Domain of unknown function (DUF5101) zf-UDP PF14569.6 EDO08556.1 - 1.4 9.1 7.1 4.4 7.5 7.1 1.8 1 1 0 1 1 1 0 Zinc-binding RING-finger RGCC PF15151.6 EDO08556.1 - 1.5 9.0 6.0 0.28 11.4 0.6 2.6 2 0 0 2 2 2 0 Response gene to complement 32 protein family YabA PF06156.13 EDO08556.1 - 1.8 9.2 22.6 18 6.0 1.4 5.7 3 1 3 6 6 5 0 Initiation control protein YabA zf-Nse PF11789.8 EDO08556.1 - 4.3 7.2 7.1 11 5.9 7.1 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Swi5 PF07061.11 EDO08556.1 - 8.1 6.6 12.8 2.1 8.5 1.5 4.1 3 1 0 3 3 3 0 Swi5 DUF5082 PF16888.5 EDO08556.1 - 8.3 6.7 18.3 6.9 7.0 0.1 5.2 2 1 3 5 5 5 0 Domain of unknown function (DUF5082) Herpes_BLRF2 PF05812.12 EDO08556.1 - 8.6 6.5 11.4 5.8 7.1 0.6 4.2 3 1 1 4 4 4 0 Herpesvirus BLRF2 protein HrpB7 PF09486.10 EDO08556.1 - 9.7 6.6 17.4 0.66 10.4 5.7 3.5 3 1 1 4 4 4 0 Bacterial type III secretion protein (HrpB7) HSP70 PF00012.20 EDO08557.1 - 5.1e-253 840.7 6.6 5.8e-253 840.5 6.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDO08557.1 - 5.8e-15 54.9 0.4 8.4e-14 51.1 0.2 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 EDO08557.1 - 0.0028 18.1 1.5 3 8.3 0.0 3.7 3 1 0 3 3 3 1 Cell division protein FtsA DDR PF08841.10 EDO08557.1 - 0.0034 16.4 0.2 0.25 10.3 0.1 2.3 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain Hydantoinase_A PF01968.18 EDO08557.1 - 0.079 12.2 0.5 0.33 10.2 0.1 2.1 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase StbA PF06406.11 EDO08557.1 - 0.092 12.0 0.1 0.29 10.3 0.0 1.8 2 0 0 2 2 2 0 StbA protein FGGY_C PF02782.16 EDO08557.1 - 0.1 12.3 0.0 1.1 9.0 0.0 2.6 3 0 0 3 3 3 0 FGGY family of carbohydrate kinases, C-terminal domain APP_N PF02177.16 EDO08557.1 - 0.13 12.6 0.1 0.31 11.4 0.1 1.6 1 0 0 1 1 1 0 Amyloid A4 N-terminal heparin-binding Radical_SAM_C PF16199.5 EDO08558.1 - 1.3e-19 70.0 0.1 8.3e-19 67.4 0.1 2.3 2 0 0 2 2 2 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 EDO08558.1 - 5.5e-14 52.9 0.1 2e-13 51.1 0.1 1.9 1 0 0 1 1 1 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 EDO08558.1 - 8.9e-06 25.9 0.2 2.4e-05 24.5 0.2 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDO08558.1 - 0.011 15.7 0.0 0.026 14.5 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain ERCC3_RAD25_C PF16203.5 EDO08559.1 - 2.9e-109 364.1 0.2 5e-109 363.3 0.2 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 EDO08559.1 - 7.9e-31 106.8 0.0 2.7e-30 105.1 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO08559.1 - 5.7e-16 59.0 0.0 1.6e-15 57.5 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDO08559.1 - 3.8e-11 43.3 0.1 1.3e-10 41.6 0.1 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain LDcluster4 PF18306.1 EDO08559.1 - 0.11 12.0 0.1 0.35 10.4 0.1 1.8 1 1 1 2 2 2 0 SLOG cluster4 family DUF2556 PF10831.8 EDO08559.1 - 0.13 12.2 0.1 0.42 10.6 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2556) DUF1971 PF09313.11 EDO08559.1 - 0.15 12.1 0.0 1.6 8.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1971) Dynamin_M PF01031.20 EDO08560.1 - 4.8e-92 308.2 0.3 4.8e-92 308.2 0.3 1.9 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 EDO08560.1 - 8.1e-51 172.4 0.9 3.1e-50 170.5 0.0 2.3 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 EDO08560.1 - 5.1e-27 93.9 5.2 5.1e-27 93.9 5.2 2.1 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EDO08560.1 - 3.4e-06 27.1 0.0 2e-05 24.7 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Condensin2nSMC PF12422.8 EDO08560.1 - 0.0084 16.3 3.5 0.025 14.8 0.3 2.9 3 0 0 3 3 3 1 Condensin II non structural maintenance of chromosomes subunit AAA_16 PF13191.6 EDO08560.1 - 0.014 15.7 0.0 0.046 14.1 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain AAA_15 PF13175.6 EDO08560.1 - 0.023 14.4 0.3 1.3 8.7 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain FeoB_N PF02421.18 EDO08560.1 - 0.092 12.3 0.5 12 5.4 0.0 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B ubiquitin PF00240.23 EDO08561.1 - 2.5e-28 97.6 2.1 2e-27 94.8 2.7 1.9 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 EDO08561.1 - 2.1e-12 46.7 3.1 4.1e-12 45.8 3.1 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EDO08561.1 - 6.9e-05 23.2 1.7 0.00047 20.6 0.8 2.5 2 1 0 2 2 2 1 Ubiquitin-like domain Ubiquitin_4 PF18036.1 EDO08561.1 - 8e-05 22.6 2.2 0.077 13.0 0.5 2.4 1 1 1 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EDO08561.1 - 0.00041 20.4 0.4 0.0012 18.9 0.4 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EDO08561.1 - 0.00094 19.5 0.7 0.0017 18.7 0.7 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EDO08561.1 - 0.0036 17.2 0.5 0.0058 16.5 0.5 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 EDO08561.1 - 0.039 14.5 0.1 0.063 13.8 0.1 1.4 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Mito_carr PF00153.27 EDO08562.1 - 4.8e-67 221.9 5.8 5.3e-24 84.0 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.19 EDO08562.1 - 0.0066 16.8 2.8 0.17 12.3 0.2 2.5 2 1 0 2 2 2 2 Tim17/Tim22/Tim23/Pmp24 family Cation_ATPase PF13246.6 EDO08562.1 - 0.14 12.2 0.0 0.43 10.7 0.0 1.6 1 1 0 1 1 1 0 Cation transport ATPase (P-type) Peptidase_C1 PF00112.23 EDO08563.1 - 4.8e-56 190.3 0.0 7.2e-56 189.7 0.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EDO08563.1 - 3.9e-14 52.8 8.3 2.2e-12 47.2 7.6 2.3 2 0 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EDO08563.1 - 1.7e-07 30.4 0.1 3.4e-05 22.8 0.0 2.3 2 0 0 2 2 2 2 Peptidase C1-like family Pkinase PF00069.25 EDO08564.1 - 5.1e-58 196.5 0.0 7.4e-58 196.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO08564.1 - 3.5e-36 124.8 0.0 5.2e-36 124.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO08564.1 - 0.0032 16.8 0.1 0.04 13.2 0.0 2.2 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EDO08564.1 - 0.0069 16.3 1.8 0.27 11.1 0.2 2.9 2 1 1 3 3 3 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EDO08564.1 - 0.098 11.4 0.0 0.19 10.5 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase S4 PF01479.25 EDO08566.1 - 2.1e-09 36.9 0.1 5.6e-09 35.6 0.1 1.7 2 0 0 2 2 2 1 S4 domain S4_2 PF13275.6 EDO08566.1 - 0.07 13.0 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 S4 domain Hexapep PF00132.24 EDO08567.1 - 0.067 12.9 0.2 0.13 12.0 0.2 1.5 1 0 0 1 1 1 0 Bacterial transferase hexapeptide (six repeats) DNA_pol_B PF00136.21 EDO08568.1 - 2.6e-74 250.6 0.4 5e-74 249.7 0.4 1.5 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EDO08568.1 - 3.7e-22 78.9 5.8 1.3e-11 44.3 0.2 4.4 4 0 0 4 4 4 3 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EDO08568.1 - 0.00073 19.9 2.6 0.0023 18.3 2.6 1.8 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta PK PF00224.21 EDO08569.1 - 1.8e-87 293.5 0.3 5.4e-48 163.6 0.1 2.2 2 0 0 2 2 2 2 Pyruvate kinase, barrel domain PK_C PF02887.16 EDO08569.1 - 0.0064 16.7 0.0 0.017 15.4 0.0 1.7 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain Mic1 PF07035.12 EDO08571.1 - 5.8e-10 39.1 1.1 1.2e-09 38.1 1.1 1.5 1 0 0 1 1 1 1 Colon cancer-associated protein Mic1-like Integrase_H2C2 PF17921.1 EDO08571.1 - 0.085 13.0 1.0 16 5.7 0.0 2.6 2 0 0 2 2 2 0 Integrase zinc binding domain RAP PF08373.10 EDO08573.1 - 1.2e-18 66.9 0.3 3.4e-18 65.5 0.3 1.7 1 0 0 1 1 1 1 RAP domain MTES_1575 PF18741.1 EDO08573.1 - 1.9e-11 44.0 0.1 5.4e-11 42.5 0.0 1.8 2 0 0 2 2 2 1 REase_MTES_1575 DUF559 PF04480.12 EDO08573.1 - 0.0011 18.8 0.0 0.0027 17.5 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF559) DUF3657 PF12394.8 EDO08574.1 - 0.0068 16.9 0.0 0.024 15.2 0.0 2.0 1 0 0 1 1 1 1 Protein FAM135 DUF676 PF05057.14 EDO08574.1 - 0.057 12.9 0.1 0.16 11.4 0.0 1.8 2 0 0 2 2 2 0 Putative serine esterase (DUF676) Asp_protease PF09668.10 EDO08575.1 - 2.7e-43 146.7 1.1 5e-43 145.8 1.1 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 EDO08575.1 - 2e-13 50.7 0.1 4.7e-13 49.5 0.1 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease ubiquitin PF00240.23 EDO08575.1 - 4.1e-09 36.1 0.0 8.9e-09 35.0 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Asp_protease_2 PF13650.6 EDO08575.1 - 3.8e-08 33.9 0.0 8.3e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 EDO08575.1 - 1.8e-06 28.1 0.1 6e-06 26.5 0.1 1.9 1 0 0 1 1 1 1 Retroviral aspartyl protease Peptidase_A2B PF12384.8 EDO08575.1 - 0.0081 15.7 1.2 0.049 13.2 0.0 2.4 3 0 0 3 3 3 1 Ty3 transposon peptidase Ubiquitin_2 PF14560.6 EDO08575.1 - 0.089 13.3 0.0 0.2 12.1 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-like domain Mac PF12464.8 EDO08575.1 - 0.093 13.0 0.6 0.22 11.8 0.6 1.6 1 0 0 1 1 1 0 Maltose acetyltransferase Tetraspanin PF00335.20 EDO08576.1 - 0.087 12.5 5.9 0.042 13.6 1.8 2.0 1 1 1 2 2 2 0 Tetraspanin family His_Phos_1 PF00300.22 EDO08578.1 - 0.00089 19.0 0.0 0.011 15.4 0.0 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) OHA PF14418.6 EDO08579.1 - 4.9e-23 80.7 0.0 8.5e-23 80.0 0.0 1.4 1 0 0 1 1 1 1 OST-HTH Associated domain OST-HTH PF12872.7 EDO08579.1 - 2.7e-06 27.1 0.0 5.7e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 OST-HTH/LOTUS domain DUF4364 PF14277.6 EDO08579.1 - 0.017 14.9 0.5 0.12 12.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4364) tRNA_bind PF01588.20 EDO08580.1 - 4.8e-26 90.7 0.0 7.6e-26 90.1 0.0 1.3 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C PF00043.25 EDO08580.1 - 1.9e-07 31.2 0.0 3.7e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EDO08580.1 - 1.3e-05 25.4 0.0 2.8e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EDO08580.1 - 0.0011 18.9 0.0 0.0019 18.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EDO08580.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DEAD PF00270.29 EDO08581.1 - 2.6e-42 144.6 0.2 5.1e-42 143.6 0.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO08581.1 - 1.2e-32 112.5 0.6 4.5e-32 110.7 0.1 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO08581.1 - 7.7e-06 26.0 0.0 1.4e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EDO08581.1 - 0.00013 21.7 0.0 0.00024 20.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDO08581.1 - 0.0004 20.8 0.2 0.0018 18.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain Helicase_RecD PF05127.14 EDO08581.1 - 0.0007 19.5 0.0 0.0013 18.6 0.0 1.3 1 0 0 1 1 1 1 Helicase PhoH PF02562.16 EDO08581.1 - 0.049 13.1 0.1 0.13 11.7 0.1 1.7 1 0 0 1 1 1 0 PhoH-like protein tRNA-synt_1b PF00579.25 EDO08581.1 - 0.056 12.8 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) CMS1 PF14617.6 EDO08581.1 - 0.087 12.1 0.1 0.25 10.7 0.1 1.7 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 EDO08581.1 - 0.16 12.2 0.3 1.2 9.4 0.3 2.4 1 1 0 1 1 1 0 AAA domain DUF1491 PF07372.12 EDO08582.1 - 7.6e-06 26.2 8.9 14 6.1 0.0 5.3 5 0 0 5 5 5 5 Protein of unknown function (DUF1491) EGF_MSP1_1 PF12946.7 EDO08582.1 - 0.012 15.7 13.3 0.013 15.6 9.9 2.3 2 0 0 2 2 2 0 MSP1 EGF domain 1 Plasmod_Pvs28 PF06247.11 EDO08582.1 - 0.029 14.7 11.3 0.073 13.4 11.3 1.7 1 0 0 1 1 1 0 Pvs28 EGF domain EGF_3 PF12947.7 EDO08582.1 - 0.03 14.5 5.4 0.097 12.9 5.4 1.9 1 0 0 1 1 1 0 EGF domain EB PF01683.18 EDO08582.1 - 0.17 12.2 7.8 0.15 12.3 6.0 1.8 2 0 0 2 2 2 0 EB module EGF PF00008.27 EDO08582.1 - 0.7 10.2 5.0 2 8.8 5.0 1.8 1 0 0 1 1 1 0 EGF-like domain DER1 PF04511.15 EDO08583.1 - 6e-15 55.7 1.1 6.4e-15 55.6 1.1 1.0 1 0 0 1 1 1 1 Der1-like family Kelch_5 PF13854.6 EDO08584.1 - 2e-22 78.7 0.0 0.0001 22.2 0.0 6.6 6 0 0 6 6 6 3 Kelch motif Kelch_4 PF13418.6 EDO08584.1 - 4.8e-21 74.5 7.9 2e-05 24.5 0.0 6.5 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.6 EDO08584.1 - 2.7e-20 72.1 0.4 0.00038 20.7 0.0 6.0 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_6 PF13964.6 EDO08584.1 - 2.5e-14 53.0 5.6 0.00043 20.5 0.0 5.1 4 1 1 5 5 5 4 Kelch motif Kelch_1 PF01344.25 EDO08584.1 - 1e-10 41.0 3.4 0.0022 17.5 0.0 5.2 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 EDO08584.1 - 3.5e-10 39.4 2.2 9.3e-06 25.4 0.0 4.0 4 0 0 4 4 4 2 Kelch motif HATPase_c_3 PF13589.6 EDO08584.1 - 2.1e-08 34.1 0.0 5.2e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EDO08584.1 - 0.00031 21.2 0.0 0.00063 20.2 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SMC_N PF02463.19 EDO08586.1 - 6.9e-56 189.1 60.4 4.5e-55 186.5 60.4 2.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EDO08586.1 - 2e-21 76.4 1.2 3.1e-20 72.6 0.0 2.8 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EDO08586.1 - 2.7e-12 47.1 9.4 7e-07 29.3 0.0 3.4 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EDO08586.1 - 3.1e-10 40.9 21.1 3.1e-10 40.9 21.1 8.3 2 2 2 4 4 1 1 AAA domain AAA_15 PF13175.6 EDO08586.1 - 2e-09 37.7 19.7 2e-09 37.7 19.7 5.3 2 2 3 5 5 2 1 AAA ATPase domain AAA_29 PF13555.6 EDO08586.1 - 2.7e-06 27.0 0.0 6.9e-06 25.7 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain Spc7 PF08317.11 EDO08586.1 - 0.0048 15.8 133.1 0.13 11.1 17.8 8.3 2 2 6 8 8 8 6 Spc7 kinetochore protein Herpes_IE2_3 PF03361.14 EDO08586.1 - 0.017 15.0 11.7 0.72 9.7 0.0 4.4 4 0 0 4 4 4 0 Herpes virus intermediate/early protein 2/3 ABC_tran PF00005.27 EDO08586.1 - 0.25 11.8 0.0 0.25 11.8 0.0 6.1 5 2 1 6 6 5 0 ABC transporter Receptor_IA-2 PF11548.8 EDO08586.1 - 3.6 7.6 9.4 0.24 11.4 1.6 3.3 3 0 0 3 3 3 0 Protein-tyrosine phosphatase receptor IA-2 MtrB PF05440.12 EDO08586.1 - 3.8 8.0 15.0 4.5 7.8 0.2 5.0 5 1 0 5 5 5 0 Tetrahydromethanopterin S-methyltransferase subunit B Pox_A_type_inc PF04508.12 EDO08586.1 - 5.5 7.0 10.8 12 6.0 0.8 4.7 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat TMEM154 PF15102.6 EDO08587.1 - 0.00079 19.3 0.0 0.001 19.0 0.0 1.1 1 0 0 1 1 1 1 TMEM154 protein family DUF5305 PF17231.2 EDO08587.1 - 0.0018 17.7 0.0 0.0023 17.4 0.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5305) Gaa1 PF04114.14 EDO08587.1 - 0.012 14.7 0.0 0.014 14.5 0.0 1.0 1 0 0 1 1 1 0 Gaa1-like, GPI transamidase component MpPF26 PF07666.11 EDO08587.1 - 0.014 15.5 0.0 0.021 14.9 0.0 1.3 1 0 0 1 1 1 0 M penetrans paralogue family 26 DUF979 PF06166.12 EDO08587.1 - 0.031 13.5 0.0 0.037 13.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF979) DUF3377 PF11857.8 EDO08587.1 - 0.077 12.9 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) CPP1-like PF11833.8 EDO08587.1 - 0.19 11.3 0.6 0.3 10.7 0.1 1.6 1 1 1 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like PIG-X PF08320.12 EDO08588.1 - 4.8e-06 26.7 0.1 6.9e-05 22.9 0.1 2.6 2 1 0 2 2 2 1 PIG-X / PBN1 TagA PF12561.8 EDO08589.1 - 0.1 13.0 0.0 0.17 12.3 0.0 1.3 1 0 0 1 1 1 0 ToxR activated gene A lipoprotein domain MCM PF00493.23 EDO08590.1 - 1.4e-98 328.5 0.0 2e-98 328.0 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDO08590.1 - 2.2e-31 108.3 0.1 4.9e-31 107.2 0.1 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EDO08590.1 - 7.9e-28 96.7 0.3 2e-27 95.4 0.3 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM6_C PF18263.1 EDO08590.1 - 3.9e-07 30.3 3.0 9.4e-07 29.0 0.4 2.8 3 0 0 3 3 3 1 MCM6 C-terminal winged-helix domain Mg_chelatase PF01078.21 EDO08590.1 - 0.00016 21.1 0.0 0.00056 19.4 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDO08590.1 - 0.00065 19.7 0.0 0.0014 18.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) MCM_N PF14551.6 EDO08590.1 - 0.001 19.6 0.1 0.0039 17.8 0.1 2.0 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase_C PF13335.6 EDO08590.1 - 0.013 16.1 0.4 0.045 14.4 0.1 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI C-terminal AAA_3 PF07726.11 EDO08590.1 - 0.04 13.8 0.0 0.089 12.7 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RAP PF08373.10 EDO08591.1 - 2.5e-13 49.9 0.1 1.1e-12 47.8 0.2 2.1 2 0 0 2 2 2 1 RAP domain TetR_C_2 PF08361.11 EDO08591.1 - 0.018 15.1 0.0 0.073 13.2 0.0 2.0 1 0 0 1 1 1 0 MAATS-type transcriptional repressor, C-terminal region HUN PF08729.10 EDO08592.1 - 1.4e-09 37.8 5.5 2.9e-09 36.8 5.5 1.6 1 0 0 1 1 1 1 HPC2 and ubinuclein domain DUF5352 PF17303.2 EDO08592.1 - 0.027 14.3 1.2 0.042 13.7 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5352) Glyco_hydro_67C PF07477.12 EDO08592.1 - 0.038 13.5 1.1 0.25 10.9 0.1 2.6 3 1 0 3 3 3 0 Glycosyl hydrolase family 67 C-terminus LSM PF01423.22 EDO08594.1 - 3.2e-16 58.8 0.1 3.6e-16 58.6 0.1 1.1 1 0 0 1 1 1 1 LSM domain AMP-binding PF00501.28 EDO08595.1 - 1e-67 228.6 0.0 1.3e-67 228.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme YIF1 PF03878.15 EDO08596.1 - 1.6e-07 31.1 7.1 0.00042 19.9 0.3 2.2 2 0 0 2 2 2 2 YIF1 DNA_pol_A_exo1 PF01612.20 EDO08598.1 - 6.5e-24 84.6 0.0 9.6e-24 84.0 0.0 1.2 1 0 0 1 1 1 1 3'-5' exonuclease zf-C2H2_2 PF12756.7 EDO08599.1 - 3.1e-29 101.3 2.6 3.3e-25 88.4 0.5 2.4 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EDO08599.1 - 0.00023 21.7 3.6 0.023 15.5 0.7 2.8 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDO08599.1 - 0.00082 19.6 15.5 0.016 15.5 1.2 2.8 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EDO08599.1 - 0.018 15.1 2.5 0.018 15.1 2.5 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger BIR PF00653.21 EDO08599.1 - 0.11 13.1 1.1 4.4 8.0 0.1 3.1 3 0 0 3 3 3 0 Inhibitor of Apoptosis domain zf-C2HE PF16278.5 EDO08599.1 - 0.19 12.2 4.6 4.8 7.7 0.2 3.4 3 1 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-LYAR PF08790.11 EDO08599.1 - 0.33 10.9 6.6 5.9 6.9 1.4 2.8 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger Cytochrom_c3_2 PF14537.6 EDO08599.1 - 4.5 7.8 6.4 21 5.7 0.2 2.7 3 0 0 3 3 3 0 Cytochrome c3 DnaJ_C PF01556.18 EDO08601.1 - 2.9e-34 118.3 0.1 4.2e-34 117.8 0.1 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EDO08601.1 - 7.6e-18 64.4 2.1 1.3e-17 63.7 2.1 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EDO08601.1 - 3e-10 40.3 14.1 6.4e-10 39.2 14.1 1.6 1 0 0 1 1 1 1 DnaJ central domain Transcrip_act PF04949.13 EDO08601.1 - 0.0076 16.1 0.1 0.012 15.5 0.1 1.2 1 0 0 1 1 1 1 Transcriptional activator Anti-TRAP PF15777.5 EDO08601.1 - 0.23 11.5 16.8 0.19 11.7 2.0 3.9 2 1 2 4 4 4 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EDO08601.1 - 4.1 7.4 8.1 5.3 7.1 0.7 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Rep_fac-A_C PF08646.10 EDO08602.1 - 1.3e-30 106.1 0.7 5.7e-29 100.8 0.3 2.9 3 0 0 3 3 3 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 EDO08602.1 - 1.3e-29 102.0 2.4 5.5e-28 96.8 1.6 2.4 2 0 0 2 2 2 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 EDO08602.1 - 7.8e-13 48.2 0.1 1.5e-08 34.5 0.0 4.0 3 1 1 4 4 4 2 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 EDO08602.1 - 4.7e-06 26.5 2.4 0.0019 18.0 2.1 2.8 2 1 0 2 2 2 2 Cell division control protein 24, OB domain 3 DUF4503 PF14951.6 EDO08602.1 - 0.069 11.6 0.6 0.12 10.8 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4503) ribosomal_L24 PF17136.4 EDO08603.1 - 5.3e-16 58.8 0.1 9.8e-16 57.9 0.1 1.5 1 0 0 1 1 1 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.29 EDO08603.1 - 0.09 12.8 2.1 0.19 11.8 2.1 1.6 1 0 0 1 1 1 0 KOW motif Ribosomal_L16 PF00252.18 EDO08604.1 - 1.5e-40 138.3 0.0 1.9e-40 137.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e NAC PF01849.18 EDO08605.1 - 2.2e-19 69.2 0.0 4.1e-19 68.3 0.0 1.5 1 0 0 1 1 1 1 NAC domain Ribosomal_L21e PF01157.18 EDO08606.1 - 8.2e-42 141.2 2.8 1.2e-41 140.6 2.8 1.3 1 0 0 1 1 1 1 Ribosomal protein L21e Methyltransf_25 PF13649.6 EDO08607.1 - 5.4e-12 46.3 0.0 1.5e-11 44.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDO08607.1 - 1.4e-10 41.7 0.0 3.6e-10 40.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EDO08607.1 - 9e-08 31.9 0.0 1.4e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EDO08607.1 - 4e-07 30.0 0.0 7.3e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDO08607.1 - 2e-05 24.5 0.0 6.4e-05 22.8 0.0 1.7 1 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EDO08607.1 - 2.5e-05 23.9 0.0 4.8e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EDO08607.1 - 5.3e-05 23.9 0.0 0.00013 22.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EDO08607.1 - 0.00049 19.1 0.0 0.00099 18.1 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1698) Methyltransf_16 PF10294.9 EDO08607.1 - 0.0033 17.2 0.0 0.005 16.6 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase CMAS PF02353.20 EDO08607.1 - 0.0035 16.7 0.0 0.005 16.2 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase TehB PF03848.14 EDO08607.1 - 0.0054 16.2 0.0 0.0088 15.5 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_18 PF12847.7 EDO08607.1 - 0.0068 16.3 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.16 EDO08607.1 - 0.0078 16.1 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Cons_hypoth95 PF03602.15 EDO08607.1 - 0.0089 15.7 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_32 PF13679.6 EDO08607.1 - 0.016 15.2 0.0 0.026 14.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_15 PF09445.10 EDO08607.1 - 0.065 12.8 0.1 0.51 9.9 0.0 2.4 3 0 0 3 3 3 0 RNA cap guanine-N2 methyltransferase RrnaAD PF00398.20 EDO08607.1 - 0.1 11.6 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PCMT PF01135.19 EDO08607.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_3 PF01596.17 EDO08607.1 - 0.12 11.5 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase zf-CCCH PF00642.24 EDO08608.1 - 3.7e-08 33.1 15.4 2.8e-05 23.9 0.6 3.6 4 0 0 4 4 4 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 EDO08608.1 - 0.002 18.3 5.8 0.18 12.1 0.8 2.7 1 1 1 2 2 2 2 Zinc-finger containing family Torus PF16131.5 EDO08608.1 - 0.0028 18.3 7.6 0.45 11.2 0.5 3.1 2 1 1 3 3 3 2 Torus domain zf_CCCH_4 PF18345.1 EDO08608.1 - 0.025 14.6 5.5 0.025 14.6 5.5 4.1 5 0 0 5 5 5 0 Zinc finger domain zf-CCCH_2 PF14608.6 EDO08608.1 - 0.042 14.3 0.7 0.042 14.3 0.7 3.2 4 0 0 4 4 4 0 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 EDO08608.1 - 0.51 10.2 17.9 1.2 9.0 3.5 3.5 3 1 0 3 3 3 0 CCCH-type zinc finger Las1 PF04031.13 EDO08610.1 - 5.1e-36 124.1 0.2 5.8e-36 123.9 0.2 1.0 1 0 0 1 1 1 1 Las1-like Vma12 PF11712.8 EDO08611.1 - 0.019 15.0 0.4 0.032 14.3 0.1 1.6 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Ribosomal_L7Ae PF01248.26 EDO08612.1 - 1.3e-21 76.1 1.6 1.9e-21 75.6 0.6 1.8 2 0 0 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 EDO08612.1 - 0.0017 18.4 0.1 0.0028 17.7 0.1 1.4 1 0 0 1 1 1 1 RNase P subunit Pop3 Ribosomal_L5e PF17144.4 EDO08613.1 - 1.6e-80 268.9 1.5 3.7e-80 267.7 0.8 1.9 2 0 0 2 2 2 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 EDO08613.1 - 2.2e-32 111.8 5.3 5.4e-32 110.6 5.3 1.7 1 0 0 1 1 1 1 Ribosomal L18 C-terminal region DUF1476 PF07345.11 EDO08613.1 - 0.038 14.3 0.0 0.13 12.7 0.0 1.9 1 0 0 1 1 1 0 ATPase inhibitor subunit zeta Ribosomal_L18p PF00861.22 EDO08613.1 - 0.047 14.1 2.0 0.38 11.1 0.0 2.3 2 0 0 2 2 2 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast EAL PF00563.20 EDO08613.1 - 0.063 12.8 0.0 0.094 12.2 0.0 1.2 1 0 0 1 1 1 0 EAL domain KH_6 PF15985.5 EDO08614.1 - 3.5e-08 33.7 0.1 7.6e-08 32.6 0.1 1.6 1 0 0 1 1 1 1 KH domain ECR1_N PF14382.6 EDO08614.1 - 1.1e-07 31.5 0.0 1.1e-07 31.5 0.0 1.9 2 0 0 2 2 2 1 Exosome complex exonuclease RRP4 N-terminal region DUF2110 PF09883.9 EDO08614.1 - 0.072 12.7 0.0 0.097 12.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2110) Ribosomal_L29e PF01779.17 EDO08615.1 - 1.3e-20 73.4 11.9 1.3e-20 73.4 11.9 1.5 2 0 0 2 2 2 1 Ribosomal L29e protein family Peptidase_C12 PF01088.21 EDO08616.1 - 5.1e-51 173.4 0.0 6.7e-51 173.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 DUF5446 PF17522.2 EDO08616.1 - 0.084 13.1 0.1 0.16 12.1 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5446) ISP3_C PF18045.1 EDO08619.1 - 6.1e-32 109.8 0.1 7.7e-32 109.4 0.1 1.1 1 0 0 1 1 1 1 ISP3 C-terminal ISP1_C PF18161.1 EDO08619.1 - 4.5e-19 68.4 0.0 5.6e-19 68.1 0.0 1.1 1 0 0 1 1 1 1 ISP1 C-terminal CheF-arch PF04283.12 EDO08619.1 - 0.05 13.3 0.1 0.065 13.0 0.1 1.1 1 0 0 1 1 1 0 Chemotaxis signal transduction system protein F from archaea Ribosomal_L27e PF01777.18 EDO08620.1 - 1.7e-28 98.8 2.7 2.2e-28 98.4 2.7 1.2 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 EDO08620.1 - 5.2e-05 23.0 0.0 9.9e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 KOW motif zf-SNAP50_C PF12251.8 EDO08621.1 - 1.1e-44 152.6 1.2 1.6e-44 152.0 1.2 1.2 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal Myb_DNA-bind_6 PF13921.6 EDO08622.1 - 0.00064 19.9 0.2 0.0018 18.5 0.2 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 EDO08622.1 - 0.041 14.1 0.7 0.13 12.5 0.5 2.0 2 0 0 2 2 2 0 SANT/Myb-like domain of DAMP1 Pep3_Vps18 PF05131.14 EDO08623.1 - 1.4e-21 76.9 0.0 2.7e-21 76.0 0.0 1.5 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family Vps39_2 PF10367.9 EDO08623.1 - 7.3e-06 26.4 0.2 1.6e-05 25.3 0.2 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 zf-rbx1 PF12678.7 EDO08623.1 - 0.00054 20.2 2.5 0.00058 20.1 0.3 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3H2C3 PF17122.5 EDO08623.1 - 0.0049 16.9 1.8 0.01 15.8 1.8 1.5 1 0 0 1 1 1 1 Zinc-finger zf-RING_2 PF13639.6 EDO08623.1 - 0.0066 16.8 1.3 0.0066 16.8 1.3 2.9 3 0 0 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.6 EDO08623.1 - 0.016 15.2 0.7 0.044 13.8 0.7 1.8 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4 PF00097.25 EDO08623.1 - 0.016 15.1 0.9 0.046 13.6 0.9 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDO08623.1 - 0.022 14.7 5.1 0.075 13.0 5.1 2.0 1 1 0 1 1 1 0 zinc-RING finger domain zf-ANAPC11 PF12861.7 EDO08623.1 - 0.041 13.9 0.0 0.27 11.3 0.1 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 EDO08623.1 - 0.071 13.0 4.8 0.051 13.4 2.0 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) ITAM_Cys-rich PF10538.9 EDO08623.1 - 0.12 12.2 0.4 0.39 10.5 0.4 1.9 1 0 0 1 1 1 0 Immunoreceptor tyrosine-based activation motif Zn_ribbon_17 PF17120.5 EDO08623.1 - 1.5 8.5 8.6 0.093 12.4 1.0 2.7 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 EDO08623.1 - 3.1 7.6 15.7 0.023 14.4 6.4 2.5 3 0 0 3 3 3 0 RING-like zinc finger SoxZ PF08770.11 EDO08624.1 - 0.11 12.3 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 Sulphur oxidation protein SoxZ DUF2070 PF09843.9 EDO08625.1 - 0.0054 15.1 8.2 0.0029 16.0 6.5 1.4 2 0 0 2 2 2 1 Predicted membrane protein (DUF2070) TctB PF07331.11 EDO08625.1 - 0.014 15.7 16.0 0.044 14.1 16.0 1.8 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family DctQ PF04290.12 EDO08625.1 - 0.017 15.0 1.4 0.017 15.0 1.4 2.5 1 1 1 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component DUF898 PF05987.13 EDO08625.1 - 0.027 13.5 0.2 0.027 13.5 0.2 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF898) Wzy_C_2 PF11846.8 EDO08625.1 - 0.058 13.3 2.1 7.2 6.5 0.2 2.9 1 1 3 4 4 4 0 Virulence factor membrane-bound polymerase, C-terminal Cation_ATPase_C PF00689.21 EDO08625.1 - 0.18 11.5 9.9 0.13 11.9 8.4 1.5 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus DUF4231 PF14015.6 EDO08625.1 - 0.18 12.2 4.6 0.95 10.0 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) DUF3087 PF11286.8 EDO08625.1 - 0.21 11.1 1.9 0.45 10.0 1.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3087) Spo7 PF03907.13 EDO08625.1 - 0.25 10.8 0.7 0.65 9.4 0.0 1.8 1 1 1 2 2 2 0 Spo7-like protein MscS_TM PF12794.7 EDO08625.1 - 0.49 9.2 4.8 0.28 10.0 0.4 1.8 1 1 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 FtsX PF02687.21 EDO08625.1 - 1.4 9.5 19.2 33 5.0 13.2 3.2 1 1 1 2 2 2 0 FtsX-like permease family Ni_hydr_CYTB PF01292.20 EDO08625.1 - 2.1 7.9 5.8 2 8.0 0.7 2.3 1 1 2 3 3 3 0 Prokaryotic cytochrome b561 DUF4131 PF13567.6 EDO08625.1 - 2.5 7.7 4.1 2.1 8.0 0.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) ABC_export PF16962.5 EDO08625.1 - 4 5.8 15.7 8.9 4.6 13.0 2.0 1 1 0 1 1 1 0 Putative ABC exporter OppC_N PF12911.7 EDO08625.1 - 4.1 7.5 19.6 12 5.9 0.0 4.3 3 1 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C DXP_redisom_C PF08436.12 EDO08626.1 - 3.9e-35 119.9 0.0 1.1e-34 118.4 0.0 1.8 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain DXP_reductoisom PF02670.16 EDO08626.1 - 6.1e-34 117.5 0.1 1.1e-33 116.7 0.1 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase DXPR_C PF13288.6 EDO08626.1 - 1.6e-32 112.2 0.0 2.7e-32 111.4 0.0 1.4 1 0 0 1 1 1 1 DXP reductoisomerase C-terminal domain Usp PF00582.26 EDO08626.1 - 0.0021 18.5 0.0 0.0053 17.3 0.0 1.6 1 0 0 1 1 1 1 Universal stress protein family FAD_binding_2 PF00890.24 EDO08626.1 - 0.021 13.9 0.0 0.031 13.4 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain MPP6 PF10175.9 EDO08628.1 - 0.68 10.4 4.4 1.3 9.5 4.4 1.5 1 0 0 1 1 1 0 M-phase phosphoprotein 6 Spc7 PF08317.11 EDO08629.1 - 2e-06 26.9 48.3 0.00015 20.7 20.9 3.1 1 1 2 3 3 3 2 Spc7 kinetochore protein BRE1 PF08647.11 EDO08629.1 - 4.7e-05 23.4 4.7 4.7e-05 23.4 4.7 4.4 1 1 4 5 5 5 2 BRE1 E3 ubiquitin ligase HrpB7 PF09486.10 EDO08629.1 - 6.5e-05 23.4 13.0 6.5e-05 23.4 13.0 3.9 1 1 3 4 4 4 1 Bacterial type III secretion protein (HrpB7) APG6_N PF17675.1 EDO08629.1 - 0.00034 21.1 50.0 0.018 15.5 15.9 4.0 1 1 3 4 4 4 3 Apg6 coiled-coil region Phage_GP20 PF06810.11 EDO08629.1 - 0.0011 18.7 0.3 0.0011 18.7 0.3 5.1 2 1 3 5 5 5 1 Phage minor structural protein GP20 Tropomyosin PF00261.20 EDO08629.1 - 0.0014 18.0 38.8 0.0034 16.8 6.6 3.5 2 1 1 3 3 3 2 Tropomyosin CENP-F_leu_zip PF10473.9 EDO08629.1 - 0.0033 17.5 11.7 0.0033 17.5 11.7 4.0 2 1 2 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fez1 PF06818.15 EDO08629.1 - 0.0055 17.2 46.7 0.012 16.1 17.7 2.4 1 1 1 2 2 2 1 Fez1 DUF812 PF05667.11 EDO08629.1 - 0.0085 15.0 44.7 0.024 13.6 33.3 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF812) ATG16 PF08614.11 EDO08629.1 - 0.02 15.1 56.8 1.4 9.1 19.6 3.4 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) TMF_DNA_bd PF12329.8 EDO08629.1 - 0.022 14.7 0.3 0.022 14.7 0.3 5.4 2 2 3 5 5 5 0 TATA element modulatory factor 1 DNA binding KASH_CCD PF14662.6 EDO08629.1 - 0.076 12.8 51.2 0.066 13.0 25.9 3.2 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH Myosin_tail_1 PF01576.19 EDO08629.1 - 0.093 10.5 48.6 0.55 8.0 48.6 2.2 1 1 0 1 1 1 0 Myosin tail GAS PF13851.6 EDO08629.1 - 0.093 12.1 48.9 0.67 9.3 4.9 3.3 1 1 3 4 4 4 0 Growth-arrest specific micro-tubule binding ADIP PF11559.8 EDO08629.1 - 0.24 11.5 58.7 0.016 15.3 6.9 4.9 1 1 4 5 5 5 0 Afadin- and alpha -actinin-Binding DUF4201 PF13870.6 EDO08629.1 - 0.25 11.0 43.3 0.049 13.4 12.3 3.9 1 1 0 3 3 3 0 Domain of unknown function (DUF4201) HAP1_N PF04849.13 EDO08629.1 - 0.49 9.5 49.7 0.4 9.9 23.5 2.6 1 1 0 2 2 2 0 HAP1 N-terminal conserved region ERM PF00769.19 EDO08629.1 - 0.88 9.3 51.5 0.018 14.9 15.8 3.0 1 1 2 3 3 3 0 Ezrin/radixin/moesin family MCPsignal PF00015.21 EDO08629.1 - 1.7 8.4 17.6 0.099 12.5 6.0 3.1 3 1 1 4 4 4 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1664 PF07889.12 EDO08629.1 - 2.2 8.3 30.7 2 8.4 3.0 4.5 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) MAD PF05557.13 EDO08629.1 - 2.3 6.5 50.0 2.2 6.5 28.8 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein IFT57 PF10498.9 EDO08629.1 - 2.6 6.9 41.2 0.77 8.7 3.9 3.0 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 FUSC PF04632.12 EDO08629.1 - 3.9 5.9 30.2 0.1 11.1 7.8 2.3 1 1 0 2 2 2 0 Fusaric acid resistance protein family DUF4472 PF14739.6 EDO08629.1 - 4.7 8.0 37.2 0.58 10.9 7.3 3.9 1 1 4 5 5 5 0 Domain of unknown function (DUF4472) TACC_C PF05010.14 EDO08629.1 - 4.9 6.9 41.2 11 5.8 17.6 3.0 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal EzrA PF06160.12 EDO08629.1 - 6.2 4.9 33.9 8.5 4.4 13.6 2.8 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA FYVE PF01363.21 EDO08630.1 - 5.9e-07 29.5 10.2 1.4e-06 28.3 10.2 1.6 1 0 0 1 1 1 1 FYVE zinc finger GAS PF13851.6 EDO08630.1 - 0.0014 18.0 7.1 0.012 15.0 4.5 2.2 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding CENP-H PF05837.12 EDO08630.1 - 0.0059 17.0 13.4 0.37 11.2 1.1 3.2 2 1 1 3 3 3 2 Centromere protein H (CENP-H) DUF1664 PF07889.12 EDO08630.1 - 0.0086 16.1 1.3 0.04 14.0 0.2 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) Phage_GP20 PF06810.11 EDO08630.1 - 0.042 13.7 2.1 0.11 12.3 0.5 2.2 2 0 0 2 2 2 0 Phage minor structural protein GP20 Spc7 PF08317.11 EDO08630.1 - 0.077 11.9 7.6 0.038 12.9 3.6 1.9 2 0 0 2 2 2 0 Spc7 kinetochore protein WEMBL PF05701.11 EDO08630.1 - 0.14 10.8 7.7 0.17 10.6 2.5 2.0 2 0 0 2 2 2 0 Weak chloroplast movement under blue light HIP1_clath_bdg PF16515.5 EDO08630.1 - 0.19 12.4 11.0 1.1 9.9 5.3 2.6 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 NPV_P10 PF05531.12 EDO08630.1 - 0.25 11.8 3.1 1.4 9.4 0.7 2.7 2 1 2 4 4 4 0 Nucleopolyhedrovirus P10 protein MIP-T3_C PF17749.1 EDO08630.1 - 0.26 11.2 7.9 1.4 8.9 0.3 2.4 2 1 0 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region Mod_r PF07200.13 EDO08630.1 - 0.3 11.2 10.5 0.19 11.8 5.6 2.2 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein CENP-K PF11802.8 EDO08630.1 - 0.37 10.3 9.1 0.15 11.6 2.8 2.0 1 1 1 2 2 2 0 Centromere-associated protein K APG6_N PF17675.1 EDO08630.1 - 0.95 10.0 16.6 4 8.0 16.6 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region CCDC144C PF14915.6 EDO08630.1 - 1 8.4 13.0 0.097 11.8 5.4 2.1 1 1 0 2 2 2 0 CCDC144C protein coiled-coil region DUF733 PF05306.11 EDO08630.1 - 1.4 9.3 7.9 14 6.0 4.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF733) TMF_TATA_bd PF12325.8 EDO08630.1 - 1.4 9.2 11.9 3.6 7.9 6.1 2.9 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding GrpE PF01025.19 EDO08630.1 - 1.5 8.5 6.0 2.5 7.7 0.2 2.5 2 1 0 2 2 2 0 GrpE SKA1 PF07160.12 EDO08630.1 - 2.4 7.9 8.3 0.93 9.3 2.5 2.2 1 1 0 2 2 2 0 Spindle and kinetochore-associated protein 1 RRM_1 PF00076.22 EDO08631.1 - 3.1e-06 26.9 0.0 5.3e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EDO08631.1 - 0.00073 19.5 0.1 0.0014 18.6 0.1 1.5 1 0 0 1 1 1 1 RNA binding motif Atrophin-1 PF03154.15 EDO08631.1 - 0.13 10.5 2.1 0.15 10.4 2.1 1.0 1 0 0 1 1 1 0 Atrophin-1 family TB2_DP1_HVA22 PF03134.19 EDO08632.1 - 1.4e-15 57.0 5.5 3e-15 55.9 5.5 1.6 1 1 0 1 1 1 1 TB2/DP1, HVA22 family Ribosomal_S8 PF00410.19 EDO08633.1 - 2.6e-18 66.2 0.0 4.4e-18 65.4 0.0 1.4 1 1 0 1 1 1 1 Ribosomal protein S8 Nuf2 PF03800.14 EDO08634.1 - 5.2e-24 84.9 0.2 2.1e-23 83.0 0.0 2.2 2 0 0 2 2 2 1 Nuf2 family Flg_hook PF02120.16 EDO08634.1 - 0.041 13.8 2.9 0.15 12.0 2.9 1.9 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK Vps23_core PF09454.10 EDO08634.1 - 0.054 13.5 0.1 0.17 11.9 0.1 1.9 1 0 0 1 1 1 0 Vps23 core domain Raco_middle PF17651.1 EDO08634.1 - 0.087 12.5 0.3 0.087 12.5 0.3 2.7 3 1 1 4 4 4 0 RACo middle region DUF5624 PF18538.1 EDO08634.1 - 0.16 12.1 1.5 0.53 10.4 1.5 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5624) Filament PF00038.21 EDO08634.1 - 0.2 11.2 39.3 0.19 11.3 37.9 1.7 1 1 0 1 1 1 0 Intermediate filament protein DUF1664 PF07889.12 EDO08634.1 - 0.49 10.4 26.5 0.18 11.9 2.2 4.9 1 1 5 6 6 6 0 Protein of unknown function (DUF1664) BAR_3 PF16746.5 EDO08634.1 - 1.8 8.2 29.9 3.9 7.1 17.6 2.6 2 1 0 2 2 2 0 BAR domain of APPL family MCD_N PF17408.2 EDO08634.1 - 7.2 6.8 9.4 0.54 10.4 0.1 3.6 4 2 1 5 5 5 0 Malonyl-CoA decarboxylase N-terminal domain Pyrophosphatase PF00719.19 EDO08636.1 - 5.1e-44 149.9 0.0 6.7e-44 149.5 0.0 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase CS PF04969.16 EDO08638.1 - 0.0038 18.2 0.0 0.0085 17.1 0.0 1.6 1 0 0 1 1 1 1 CS domain FliG_N PF14842.6 EDO08638.1 - 1.4 9.4 3.7 1.1 9.8 0.2 2.4 2 1 0 2 2 2 0 FliG N-terminal domain NMT PF01233.19 EDO08639.1 - 2.8e-72 241.8 0.0 4.5e-72 241.1 0.0 1.3 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C PF02799.15 EDO08639.1 - 8.7e-62 208.3 3.4 1.3e-61 207.8 3.4 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Acetyltransf_9 PF13527.7 EDO08639.1 - 0.0058 16.7 0.0 0.016 15.3 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDO08639.1 - 0.022 15.0 0.0 0.047 13.9 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDO08639.1 - 0.15 12.0 0.0 0.43 10.5 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain AAA PF00004.29 EDO08640.1 - 1.5e-78 261.7 0.0 5.7e-46 156.2 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO08640.1 - 2.1e-18 65.8 0.6 1e-10 41.3 0.2 2.8 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EDO08640.1 - 2.6e-10 41.0 0.0 0.0013 19.1 0.0 3.9 2 1 0 3 3 3 2 AAA ATPase domain RuvB_N PF05496.12 EDO08640.1 - 1.2e-09 38.2 0.0 0.00078 19.2 0.0 2.9 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EDO08640.1 - 2.6e-08 34.0 0.0 0.0022 18.0 0.0 4.2 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EDO08640.1 - 4e-08 33.6 0.0 0.0024 18.0 0.0 2.7 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.22 EDO08640.1 - 3.6e-07 30.5 0.0 0.0091 16.4 0.0 2.8 2 0 0 2 2 2 2 RNA helicase TIP49 PF06068.13 EDO08640.1 - 1.2e-06 28.0 0.0 0.013 14.7 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain Mg_chelatase PF01078.21 EDO08640.1 - 3.4e-06 26.6 0.0 0.013 14.9 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 EDO08640.1 - 4.1e-06 27.1 0.1 0.056 13.7 0.0 4.3 2 2 1 3 3 3 1 AAA domain AAA_7 PF12775.7 EDO08640.1 - 3.6e-05 23.3 0.0 0.17 11.3 0.0 3.0 2 1 0 2 2 2 2 P-loop containing dynein motor region Rad17 PF03215.15 EDO08640.1 - 8.9e-05 22.5 0.1 0.47 10.3 0.0 2.9 2 1 0 2 2 2 2 Rad17 P-loop domain AAA_18 PF13238.6 EDO08640.1 - 0.00011 22.7 0.0 0.038 14.5 0.0 3.3 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EDO08640.1 - 0.00017 21.4 0.0 0.55 9.9 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein ATPase PF06745.13 EDO08640.1 - 0.0006 19.2 0.5 4.1 6.7 0.0 3.6 3 1 0 4 4 3 2 KaiC Zeta_toxin PF06414.12 EDO08640.1 - 0.00063 19.1 0.0 0.15 11.3 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin ATPase_2 PF01637.18 EDO08640.1 - 0.00086 19.3 0.3 0.29 11.0 0.0 3.8 3 2 1 4 4 3 1 ATPase domain predominantly from Archaea DUF815 PF05673.13 EDO08640.1 - 0.00092 18.4 0.0 0.17 11.1 0.0 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF815) NB-ARC PF00931.22 EDO08640.1 - 0.0013 18.0 0.0 0.12 11.5 0.0 2.8 2 1 0 2 2 2 1 NB-ARC domain AAA_33 PF13671.6 EDO08640.1 - 0.0013 18.9 0.0 2.3 8.4 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_28 PF13521.6 EDO08640.1 - 0.0015 18.8 0.0 0.15 12.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EDO08640.1 - 0.0018 18.8 0.0 0.21 12.1 0.0 2.6 2 0 0 2 2 2 1 ABC transporter NACHT PF05729.12 EDO08640.1 - 0.0023 17.9 0.0 0.15 12.0 0.0 3.1 3 0 0 3 3 3 1 NACHT domain Sigma54_activ_2 PF14532.6 EDO08640.1 - 0.0025 18.0 0.0 0.78 9.9 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain Sigma54_activat PF00158.26 EDO08640.1 - 0.0025 17.5 0.0 0.74 9.5 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_24 PF13479.6 EDO08640.1 - 0.0034 17.1 0.0 0.06 13.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EDO08640.1 - 0.0053 16.6 0.4 1 9.1 0.0 2.7 3 0 0 3 3 3 1 AAA domain KAP_NTPase PF07693.14 EDO08640.1 - 0.0094 15.2 0.0 0.024 13.9 0.0 1.7 1 0 0 1 1 1 1 KAP family P-loop domain AAA_25 PF13481.6 EDO08640.1 - 0.011 15.3 0.2 5.9 6.4 0.0 3.1 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 EDO08640.1 - 0.016 15.2 0.0 6.4 6.8 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 EDO08640.1 - 0.02 14.0 0.0 0.5 9.4 0.0 2.3 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_3 PF07726.11 EDO08640.1 - 0.036 13.9 0.0 5.2 6.9 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Bac_DnaA PF00308.18 EDO08640.1 - 0.046 13.5 0.0 1.9 8.3 0.0 3.1 2 1 0 2 2 2 0 Bacterial dnaA protein AAA_PrkA PF08298.11 EDO08640.1 - 0.048 12.6 0.0 0.09 11.7 0.0 1.4 1 0 0 1 1 1 0 PrkA AAA domain TniB PF05621.11 EDO08640.1 - 0.054 12.9 0.0 0.3 10.5 0.0 2.2 3 0 0 3 3 2 0 Bacterial TniB protein RVT_1 PF00078.27 EDO08640.1 - 0.1 12.1 0.0 4.3 6.8 0.0 2.4 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) AAA_17 PF13207.6 EDO08640.1 - 0.1 13.0 0.0 4.4 7.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 EDO08640.1 - 0.15 12.4 0.0 1.9 8.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain AFG1_ATPase PF03969.16 EDO08640.1 - 0.17 10.7 0.0 1.6 7.5 0.0 2.1 2 0 0 2 2 2 0 AFG1-like ATPase DS PF01916.17 EDO08641.1 - 2.8e-127 423.9 0.0 3.2e-127 423.7 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Actin PF00022.19 EDO08642.1 - 4e-103 345.2 0.0 7.3e-101 337.7 0.0 2.0 1 1 0 1 1 1 1 Actin PIP5K PF01504.18 EDO08643.1 - 1.1e-33 116.6 0.0 8.9e-24 84.2 0.0 2.4 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 EDO08643.1 - 1.2e-09 37.3 0.0 2.1e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PIR PF00399.19 EDO08643.1 - 0.26 10.9 1.4 0.47 10.1 1.4 1.4 1 0 0 1 1 1 0 Yeast PIR protein repeat NTF2 PF02136.20 EDO08645.1 - 2.3e-25 89.5 0.0 2.6e-25 89.3 0.0 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Pro_isomerase PF00160.21 EDO08646.1 - 2.8e-43 147.9 0.1 3.7e-43 147.5 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ribosomal_TL5_C PF14693.6 EDO08647.1 - 0.0032 17.8 0.0 0.0052 17.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein TL5, C-terminal domain Ribosomal_L25p PF01386.19 EDO08647.1 - 0.03 14.8 0.0 0.078 13.5 0.0 1.7 1 0 0 1 1 1 0 Ribosomal L25p family Cuticle_2 PF08184.11 EDO08647.1 - 0.066 13.2 0.1 8.2 6.5 0.0 3.0 3 0 0 3 3 3 0 Cuticle protein 7 isoform family Aminotran_1_2 PF00155.21 EDO08648.1 - 1.4e-50 172.5 0.0 1.6e-50 172.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II COX5B PF01215.19 EDO08649.1 - 1.1e-10 41.3 0.0 1.8e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb Histone PF00125.24 EDO08650.1 - 2.1e-20 73.4 0.1 2.1e-20 73.4 0.1 2.6 2 1 1 3 3 3 1 Core histone H2A/H2B/H3/H4 UPF0061 PF02696.14 EDO08650.1 - 0.24 10.1 1.0 0.36 9.5 1.0 1.2 1 0 0 1 1 1 0 Uncharacterized ACR, YdiU/UPF0061 family Metallophos PF00149.28 EDO08651.1 - 9.7e-38 130.7 0.1 1.4e-37 130.2 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EDO08651.1 - 0.0049 17.3 0.1 0.014 15.8 0.1 1.7 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Metallophos_2 PF12850.7 EDO08651.1 - 0.2 11.8 0.0 0.29 11.3 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain zf-RRN7 PF11781.8 EDO08651.1 - 0.21 11.3 2.4 1 9.1 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 SLBP_RNA_bind PF15247.6 EDO08652.1 - 2.2e-23 82.1 0.7 2.2e-23 82.1 0.7 2.2 3 0 0 3 3 3 1 Histone RNA hairpin-binding protein RNA-binding domain tRNA-synt_2b PF00587.25 EDO08653.1 - 1.8e-28 99.7 0.1 2.7e-28 99.1 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EDO08653.1 - 1.5e-05 25.0 0.0 3.9e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2 PF00152.20 EDO08653.1 - 0.015 14.4 0.1 0.028 13.5 0.1 1.5 1 1 0 1 1 1 0 tRNA synthetases class II (D, K and N) Hist_deacetyl PF00850.19 EDO08654.1 - 1.8e-77 260.8 0.2 2.2e-77 260.5 0.2 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Yippee-Mis18 PF03226.14 EDO08655.1 - 4.1e-16 59.1 0.2 4.7e-16 58.9 0.2 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly SelR PF01641.18 EDO08655.1 - 6.9e-05 22.9 1.0 9e-05 22.5 1.0 1.1 1 0 0 1 1 1 1 SelR domain HECT_2 PF09814.9 EDO08655.1 - 0.0047 15.8 0.4 1.1 8.1 0.1 2.1 2 0 0 2 2 2 2 HECT-like Ubiquitin-conjugating enzyme (E2)-binding RIG-I_C-RD PF11648.8 EDO08655.1 - 0.0047 17.1 0.1 0.0076 16.5 0.1 1.3 1 1 0 1 1 1 1 C-terminal domain of RIG-I LIM PF00412.22 EDO08655.1 - 0.017 15.4 1.1 3.1 8.1 0.1 2.7 2 1 1 3 3 3 0 LIM domain Nudix_N_2 PF14803.6 EDO08655.1 - 0.023 14.6 2.5 1.9 8.5 0.2 3.1 3 0 0 3 3 3 0 Nudix N-terminal zinc_ribbon_2 PF13240.6 EDO08655.1 - 0.15 11.8 3.7 1.1 9.1 0.1 2.9 3 0 0 3 3 3 0 zinc-ribbon domain HypA PF01155.19 EDO08655.1 - 0.18 11.9 0.7 2.8 8.0 0.4 2.0 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Ribosomal_S27e PF01667.17 EDO08655.1 - 0.19 11.5 1.0 6.8 6.5 0.0 2.7 3 0 0 3 3 3 0 Ribosomal protein S27 zf_C2H2_13 PF18508.1 EDO08655.1 - 1 9.0 3.2 5.4 6.7 0.0 2.7 3 0 0 3 3 3 0 Zinc finger domain Thioredoxin PF00085.20 EDO08656.1 - 1.1e-17 63.9 0.2 1.3e-17 63.6 0.2 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EDO08656.1 - 0.0046 17.3 0.0 0.012 16.0 0.0 1.6 1 1 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 EDO08656.1 - 0.01 15.2 0.0 0.01 15.2 0.0 1.2 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Glutaredoxin PF00462.24 EDO08656.1 - 0.015 15.5 0.0 0.031 14.5 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin DUF953 PF06110.11 EDO08656.1 - 0.044 13.4 0.0 0.056 13.1 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) Thioredoxin_2 PF13098.6 EDO08656.1 - 0.058 13.9 0.1 0.14 12.6 0.1 1.8 1 1 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_3 PF13192.6 EDO08656.1 - 0.066 13.3 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin domain Thioredoxin_7 PF13899.6 EDO08656.1 - 0.092 12.9 0.1 0.15 12.3 0.1 1.5 1 1 0 1 1 1 0 Thioredoxin-like V-ATPase_C PF03223.15 EDO08657.1 - 9.4e-79 265.5 0.5 1.2e-78 265.1 0.5 1.0 1 0 0 1 1 1 1 V-ATPase subunit C BRCT_2 PF16589.5 EDO08658.1 - 4.8e-11 42.9 0.1 1.7e-09 37.9 0.0 2.6 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain AAA_lid_7 PF17867.1 EDO08658.1 - 0.14 12.4 0.1 0.32 11.2 0.1 1.6 1 0 0 1 1 1 0 Midasin AAA lid domain MMR_HSR1 PF01926.23 EDO08660.1 - 0.0017 18.5 0.0 0.017 15.2 0.0 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDO08660.1 - 0.16 11.9 0.0 0.81 9.6 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase HECT PF00632.25 EDO08662.1 - 3.9e-86 289.3 0.0 8.8e-86 288.1 0.0 1.6 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Prion PF00377.18 EDO08662.1 - 0.042 13.7 4.2 0.22 11.4 0.1 3.5 4 0 0 4 4 4 0 Prion/Doppel alpha-helical domain LRR_6 PF13516.6 EDO08663.1 - 0.5 10.6 15.8 12 6.3 0.0 6.8 7 0 0 7 7 7 0 Leucine Rich repeat RMI2 PF16100.5 EDO08664.1 - 0.12 12.2 0.1 0.26 11.1 0.1 1.4 1 0 0 1 1 1 0 RecQ-mediated genome instability protein 2 RPA_C PF08784.11 EDO08664.1 - 0.13 12.9 1.3 0.31 11.7 1.3 1.7 1 1 0 1 1 1 0 Replication protein A C terminal Telomere_reg-2 PF10193.9 EDO08665.1 - 6.2e-05 23.4 0.9 0.0014 19.0 0.1 3.0 3 0 0 3 3 3 1 Telomere length regulation protein IF4E PF01652.18 EDO08667.1 - 3.4e-31 108.2 0.0 4.8e-31 107.7 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Glycoprotein_B PF00606.18 EDO08667.1 - 0.08 12.4 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus Glycoprotein B ectodomain ABC_tran PF00005.27 EDO08669.1 - 2.6e-37 128.4 0.0 8.1e-37 126.8 0.0 1.8 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 EDO08669.1 - 1.7e-35 123.0 4.2 2.4e-35 122.5 4.2 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 EDO08669.1 - 8.3e-07 28.7 0.4 4.8e-05 22.9 0.4 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain DEAD PF00270.29 EDO08669.1 - 3.6e-05 23.6 0.0 0.0001 22.2 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_5 PF07728.14 EDO08669.1 - 0.0062 16.5 0.1 0.15 12.1 0.1 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 EDO08669.1 - 0.0073 16.7 0.1 0.13 12.7 0.1 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 EDO08669.1 - 0.0092 16.1 0.1 0.02 15.0 0.1 1.5 1 0 0 1 1 1 1 Helicase HerA, central domain AAA_23 PF13476.6 EDO08669.1 - 0.014 15.9 0.1 0.03 14.8 0.1 1.5 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 EDO08669.1 - 0.018 15.0 0.0 0.042 13.8 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDO08669.1 - 0.031 14.6 2.0 0.12 12.7 0.7 2.5 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EDO08669.1 - 0.039 13.7 0.2 0.11 12.3 0.2 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.6 EDO08669.1 - 0.045 13.3 0.0 0.099 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EDO08669.1 - 0.051 12.6 0.0 0.081 12.0 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Mg_chelatase PF01078.21 EDO08669.1 - 0.12 11.8 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 EDO08669.1 - 0.15 11.7 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain RecA PF00154.21 EDO08669.1 - 0.17 11.3 0.0 0.33 10.4 0.0 1.4 1 0 0 1 1 1 0 recA bacterial DNA recombination protein AAA_16 PF13191.6 EDO08669.1 - 0.18 12.2 0.1 0.38 11.1 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 EDO08669.1 - 0.28 11.3 0.7 2.2 8.4 0.3 2.3 1 1 0 2 2 2 0 AAA domain AAA_21 PF13304.6 EDO08669.1 - 0.3 10.8 0.8 1.2 8.9 0.1 2.1 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system WD40 PF00400.32 EDO08670.1 - 3.7e-33 113.0 34.5 1.1e-07 32.4 0.3 12.0 11 1 0 11 11 11 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO08670.1 - 1.2e-10 41.5 0.8 0.26 11.6 0.0 8.0 4 2 2 8 8 8 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 EDO08670.1 - 2.1e-06 26.8 2.4 0.041 12.6 0.3 5.2 2 2 1 4 4 4 1 Nup133 N terminal like Utp12 PF04003.12 EDO08670.1 - 0.00078 19.7 1.8 0.002 18.4 1.8 1.7 1 0 0 1 1 1 1 Dip2/Utp12 Family HrpB7 PF09486.10 EDO08670.1 - 0.0066 16.9 0.1 0.0066 16.9 0.1 1.7 2 0 0 2 2 2 1 Bacterial type III secretion protein (HrpB7) Nup160 PF11715.8 EDO08670.1 - 0.025 13.2 0.7 6.1 5.4 0.0 3.3 3 0 0 3 3 3 0 Nucleoporin Nup120/160 WD40_like PF17005.5 EDO08670.1 - 0.059 12.7 1.4 1.2 8.3 0.0 3.5 4 0 0 4 4 4 0 WD40-like domain Val_tRNA-synt_C PF10458.9 EDO08672.1 - 0.056 13.7 0.9 22 5.4 0.4 2.9 2 0 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm DUF4264 PF14084.6 EDO08672.1 - 0.068 12.8 0.1 0.27 10.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4264) Med4 PF10018.9 EDO08672.1 - 0.22 11.2 3.7 0.5 10.0 3.7 1.6 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 Laminin_II PF06009.12 EDO08672.1 - 1 9.4 8.6 9 6.3 4.1 2.8 2 1 0 2 2 2 0 Laminin Domain II SlyX PF04102.12 EDO08672.1 - 1.5 9.5 8.1 1.6 9.4 0.9 3.5 1 1 2 3 3 3 0 SlyX DUF1664 PF07889.12 EDO08672.1 - 1.6 8.8 5.9 21 5.2 0.2 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF5082 PF16888.5 EDO08672.1 - 2.3 8.5 13.9 1.5 9.1 10.3 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) Fib_alpha PF08702.10 EDO08672.1 - 3.2 7.9 16.9 0.12 12.6 6.0 3.0 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family Tweety PF04906.13 EDO08672.1 - 3.3 6.3 4.8 11 4.6 0.4 2.4 1 1 1 2 2 2 0 Tweety Glycos_transf_2 PF00535.26 EDO08673.1 - 2e-31 109.1 0.0 2.5e-31 108.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EDO08673.1 - 2.4e-14 53.8 0.0 3e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EDO08673.1 - 6.5e-07 29.0 0.0 1e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 EDO08673.1 - 0.002 17.6 0.0 0.0035 16.9 0.0 1.4 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 EDO08673.1 - 0.097 12.6 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family group 2 Glyco_tranf_2_4 PF13704.6 EDO08673.1 - 0.14 12.7 0.0 0.25 11.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 OTU PF02338.19 EDO08674.1 - 1.2e-10 41.9 0.4 1.2e-10 41.9 0.4 1.7 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EDO08674.1 - 1.4e-07 31.2 0.3 0.0013 18.2 0.0 2.0 1 1 1 2 2 2 2 Peptidase C65 Otubain DUF2959 PF11172.8 EDO08674.1 - 0.046 13.8 2.5 2.6 8.1 2.5 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2959) NNMT_PNMT_TEMT PF01234.17 EDO08674.1 - 0.051 12.8 0.3 0.069 12.3 0.2 1.4 1 1 0 1 1 1 0 NNMT/PNMT/TEMT family Ribosomal_S8e PF01201.22 EDO08674.1 - 0.093 12.9 0.2 0.12 12.5 0.2 1.1 1 0 0 1 1 1 0 Ribosomal protein S8e EELM2 PF15863.5 EDO08675.1 - 2.4e-70 236.1 2.9 5.6e-70 234.9 2.9 1.6 1 1 0 1 1 1 1 Extended EGL-27 and MTA1 homology domain NIF PF03031.18 EDO08676.1 - 7.5e-27 94.0 0.0 1.5e-26 93.1 0.0 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF43 PF01861.16 EDO08676.1 - 0.028 13.6 0.0 0.044 13.0 0.0 1.2 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain PRTase_3 PF15610.6 EDO08676.1 - 0.06 12.6 0.0 0.096 11.9 0.0 1.2 1 0 0 1 1 1 0 PRTase ComF-like DUF2608 PF11019.8 EDO08676.1 - 0.13 11.8 0.2 0.24 10.8 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2608) Methyltransf_16 PF10294.9 EDO08677.1 - 6.9e-24 84.5 0.1 1.2e-23 83.7 0.1 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Ank_2 PF12796.7 EDO08677.1 - 9.2e-11 42.2 1.0 1.7e-10 41.3 0.3 1.9 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDO08677.1 - 2.9e-08 33.3 0.1 0.027 15.0 0.2 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 EDO08677.1 - 7.3e-07 29.6 1.1 0.0094 16.5 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EDO08677.1 - 8.8e-06 25.9 3.6 0.005 17.1 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EDO08677.1 - 0.0001 22.6 0.0 0.26 11.8 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeat Vps8 PF12816.7 EDO08677.1 - 0.042 13.3 0.0 0.069 12.7 0.0 1.3 1 0 0 1 1 1 0 Golgi CORVET complex core vacuolar protein 8 DUF4407 PF14362.6 EDO08678.1 - 0.65 9.3 4.4 2.7 7.3 4.4 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) tRNA-synt_2 PF00152.20 EDO08679.1 - 2.6e-73 246.9 0.0 8.1e-73 245.2 0.0 1.7 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDO08679.1 - 1.9e-08 34.2 0.0 3.9e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EDO08679.1 - 0.00045 19.8 0.1 0.0049 16.4 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) MFS_1 PF07690.16 EDO08680.1 - 5.2e-19 68.4 27.5 8.3e-19 67.7 27.5 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EDO08680.1 - 1.5e-05 24.1 10.7 0.0014 17.6 4.8 2.2 1 1 1 2 2 2 2 MFS_1 like family Staphostatin_A PF09022.10 EDO08685.1 - 0.024 14.5 2.7 22 5.0 0.0 3.5 3 0 0 3 3 3 0 Staphostatin A SKN1 PF03935.15 EDO08687.1 - 0.085 11.2 0.1 0.12 10.7 0.1 1.1 1 0 0 1 1 1 0 Beta-glucan synthesis-associated protein (SKN1) Chorein_N PF12624.7 EDO08691.1 - 1.9e-09 37.7 0.4 8.4e-09 35.6 0.1 2.4 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 SHR-BD PF06650.12 EDO08691.1 - 0.014 14.8 1.2 0.12 11.8 0.2 2.7 2 0 0 2 2 2 0 SHR-binding domain of vacuolar-sorting associated protein 13 XFP_N PF09364.10 EDO08691.1 - 0.11 11.3 0.2 0.66 8.7 0.0 2.0 2 0 0 2 2 2 0 XFP N-terminal domain zf-CCCH_4 PF18044.1 EDO08692.1 - 6.8e-05 22.6 4.0 6.8e-05 22.6 4.0 2.9 3 0 0 3 3 3 1 CCCH-type zinc finger zf-CCCH PF00642.24 EDO08692.1 - 0.03 14.2 3.2 0.03 14.2 3.2 3.9 4 0 0 4 4 4 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 EDO08692.1 - 0.047 14.2 14.6 0.18 12.4 6.2 2.8 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger zf_CCCH_4 PF18345.1 EDO08692.1 - 0.1 12.7 19.0 0.11 12.6 4.5 3.8 4 0 0 4 4 4 0 Zinc finger domain Torus PF16131.5 EDO08692.1 - 0.11 13.2 7.7 2 9.2 0.0 3.0 2 1 0 2 2 2 0 Torus domain RNA_pol_A_bac PF01000.26 EDO08693.1 - 7.1e-05 23.2 0.0 0.00016 22.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain MRG PF05712.13 EDO08694.1 - 0.017 14.5 1.0 0.028 13.7 1.0 1.4 1 0 0 1 1 1 0 MRG VHS PF00790.19 EDO08695.1 - 0.073 12.9 0.2 9 6.1 0.0 2.6 1 1 0 2 2 2 0 VHS domain Eclosion PF04736.12 EDO08695.1 - 0.47 10.2 1.6 0.93 9.2 0.2 2.1 2 0 0 2 2 2 0 Eclosion hormone FUN14 PF04930.15 EDO08696.1 - 1e-07 32.2 0.7 1.5e-07 31.7 0.7 1.2 1 0 0 1 1 1 1 FUN14 family Wx5_PLAF3D7 PF09688.10 EDO08698.1 - 0.00013 22.0 4.0 0.00021 21.3 3.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (Wx5_PLAF3D7) PhaP_Bmeg PF09602.10 EDO08698.1 - 0.0015 18.5 4.3 0.0023 17.9 4.3 1.3 1 0 0 1 1 1 1 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) zf-B_box PF00643.24 EDO08698.1 - 0.0032 17.6 8.5 0.007 16.5 8.5 1.6 1 0 0 1 1 1 1 B-box zinc finger Baculo_PEP_C PF04513.12 EDO08698.1 - 0.009 16.1 0.7 0.058 13.4 0.5 2.0 2 0 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus Phage_TAC_3 PF06896.11 EDO08698.1 - 0.05 14.2 1.6 0.092 13.3 1.6 1.4 1 0 0 1 1 1 0 Phage tail assembly chaperone proteins, TAC Sec20 PF03908.13 EDO08698.1 - 0.059 13.3 0.5 0.15 12.0 0.5 1.7 1 0 0 1 1 1 0 Sec20 RRF PF01765.19 EDO08698.1 - 0.078 12.9 0.3 0.14 12.1 0.3 1.4 1 0 0 1 1 1 0 Ribosome recycling factor L1R_F9L PF02442.17 EDO08698.1 - 0.12 12.2 0.5 0.21 11.4 0.5 1.4 1 0 0 1 1 1 0 Lipid membrane protein of large eukaryotic DNA viruses DUF1664 PF07889.12 EDO08698.1 - 0.27 11.3 3.4 6.3 6.9 1.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.15 EDO08698.1 - 0.34 10.4 3.4 0.47 10.0 3.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Fib_alpha PF08702.10 EDO08698.1 - 3.8 7.7 8.5 1 9.5 1.2 2.6 2 1 0 3 3 3 0 Fibrinogen alpha/beta chain family FHA PF00498.26 EDO08699.1 - 1.4e-18 67.0 0.1 2.9e-18 66.0 0.1 1.6 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EDO08699.1 - 2.5e-08 34.1 0.0 5.3e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain PI3_PI4_kinase PF00454.27 EDO08700.1 - 5.5e-37 127.9 0.0 1.4e-36 126.6 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 EDO08700.1 - 1.2e-08 34.6 0.0 4e-08 32.9 0.0 2.0 1 0 0 1 1 1 1 FATC domain TPR_14 PF13428.6 EDO08700.1 - 0.0023 18.6 1.6 11 7.2 0.0 4.4 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDO08700.1 - 0.022 14.9 1.5 1.1 9.6 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EDO08700.1 - 0.078 13.5 1.1 2.6 8.6 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDO08700.1 - 0.11 13.2 0.6 43 5.0 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat ASF1_hist_chap PF04729.13 EDO08701.1 - 3.5e-62 208.9 0.0 5.2e-62 208.4 0.0 1.3 1 0 0 1 1 1 1 ASF1 like histone chaperone Cyto_heme_lyase PF01265.17 EDO08702.1 - 5e-43 147.8 8.8 5.1e-42 144.4 8.8 1.9 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase DAHP_synth_1 PF00793.20 EDO08702.1 - 0.23 10.3 0.0 0.31 9.9 0.0 1.1 1 0 0 1 1 1 0 DAHP synthetase I family Isy1 PF06246.12 EDO08703.1 - 1.7e-62 211.3 0.4 1.9e-62 211.1 0.4 1.0 1 0 0 1 1 1 1 Isy1-like splicing family CRAL_TRIO PF00650.20 EDO08704.1 - 1.1e-32 112.9 0.0 1.7e-32 112.4 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDO08704.1 - 1.5e-05 25.1 0.4 5.7e-05 23.2 0.1 2.1 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EDO08704.1 - 0.00011 22.4 0.1 0.00022 21.4 0.1 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain ANAPC4_WD40 PF12894.7 EDO08705.1 - 0.00014 22.1 0.0 0.39 11.0 0.0 2.2 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO08705.1 - 0.021 15.7 0.2 9.1 7.3 0.0 2.6 3 0 0 3 3 3 0 WD domain, G-beta repeat RNA_pol_A_bac PF01000.26 EDO08706.1 - 1.9e-27 95.9 0.0 3.4e-27 95.0 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EDO08706.1 - 3.9e-17 61.4 0.0 5.8e-17 60.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Fer4_9 PF13187.6 EDO08706.1 - 0.0075 16.4 0.3 0.015 15.4 0.3 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 EDO08706.1 - 0.028 15.0 0.5 0.061 13.9 0.5 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain eIF-1a PF01176.19 EDO08707.1 - 2.1e-22 78.7 0.0 3e-22 78.2 0.0 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 PCI PF01399.27 EDO08708.1 - 1.8e-12 47.7 0.5 1e-11 45.3 0.0 2.5 3 0 0 3 3 3 1 PCI domain RPN5_C PF18098.1 EDO08708.1 - 2.6e-08 33.8 5.0 4.9e-08 32.9 0.3 2.8 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN5 C-terminal domain Brr6_like_C_C PF10104.9 EDO08709.1 - 4.7e-35 120.3 1.5 7e-35 119.7 1.5 1.3 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain DsbC_N PF10411.9 EDO08710.1 - 0.04 13.4 0.2 0.086 12.3 0.2 1.5 1 0 0 1 1 1 0 Disulfide bond isomerase protein N-terminus L_protein_N PF15518.6 EDO08710.1 - 0.054 13.3 0.4 0.21 11.4 0.1 2.2 2 0 0 2 2 2 0 L protein N-terminus Tcf25 PF04910.14 EDO08712.1 - 2.2e-32 112.5 0.2 2.9e-32 112.1 0.2 1.1 1 0 0 1 1 1 1 Transcriptional repressor TCF25 TPR_20 PF14561.6 EDO08712.1 - 0.13 12.6 0.0 0.31 11.4 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat FYDLN_acid PF09538.10 EDO08712.1 - 1.5 9.6 7.7 2.7 8.7 7.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) PseudoU_synth_2 PF00849.22 EDO08713.1 - 8.2e-29 100.8 0.0 1.2e-28 100.2 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase DWNN PF08783.11 EDO08714.1 - 1.2e-10 41.5 0.0 2.8e-10 40.3 0.0 1.7 1 0 0 1 1 1 1 DWNN domain zf-C3HC4 PF00097.25 EDO08714.1 - 1.6 8.7 10.9 3.3 7.7 10.9 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) NIF PF03031.18 EDO08715.1 - 1.8e-33 115.5 0.1 2.6e-33 115.0 0.1 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Sox_N PF12444.8 EDO08715.1 - 0.084 14.0 0.2 0.17 13.0 0.2 1.4 1 0 0 1 1 1 0 Sox developmental protein N terminal Vps53_N PF04100.12 EDO08716.1 - 2.6e-61 207.7 2.7 2.6e-61 207.7 2.7 1.9 3 0 0 3 3 3 1 Vps53-like, N-terminal DUF3788 PF12663.7 EDO08716.1 - 0.022 14.7 0.5 0.64 10.0 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3788) HisG PF01634.18 EDO08716.1 - 0.074 13.0 0.1 0.28 11.2 0.0 2.0 2 0 0 2 2 2 0 ATP phosphoribosyltransferase DUF885 PF05960.11 EDO08716.1 - 0.2 11.3 0.0 0.41 10.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) tRNA-synt_2c PF01411.19 EDO08717.1 - 1.1e-191 638.1 0.0 1.5e-191 637.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EDO08717.1 - 3.6e-11 43.0 0.2 8.7e-11 41.7 0.2 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Pox_A8 PF04745.12 EDO08717.1 - 0.12 11.4 0.0 3.7 6.5 0.0 2.3 2 0 0 2 2 2 0 VITF-3 subunit protein DASH_Hsk3 PF08227.11 EDO08717.1 - 0.13 12.7 0.3 0.29 11.5 0.3 1.6 1 0 0 1 1 1 0 DASH complex subunit Hsk3 like WD40 PF00400.32 EDO08718.1 - 0.0068 17.2 1.2 0.19 12.7 0.0 3.4 4 0 0 4 4 4 1 WD domain, G-beta repeat NFACT-R_1 PF05670.13 EDO08719.1 - 4.8e-11 43.3 0.0 1.5e-10 41.7 0.0 1.8 2 0 0 2 2 2 1 NFACT protein RNA binding domain NFACT-R_2 PF18297.1 EDO08719.1 - 5.7e-08 32.9 0.0 1.4e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 NFACT protein RNA binding domain FbpA PF05833.11 EDO08719.1 - 0.036 12.8 0.0 0.068 11.9 0.0 1.4 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) DUF1508 PF07411.12 EDO08719.1 - 0.14 12.1 0.6 0.73 9.7 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1508) IAT_beta PF11924.8 EDO08721.1 - 0.12 11.8 2.3 0.22 10.9 2.3 1.4 1 0 0 1 1 1 0 Inverse autotransporter, beta-domain DUF1667 PF07892.11 EDO08721.1 - 0.12 12.5 0.2 0.41 10.7 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1667) Seryl_tRNA_N PF02403.22 EDO08721.1 - 0.45 10.8 18.0 0.24 11.7 14.4 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain YtxH PF12732.7 EDO08721.1 - 0.61 10.7 7.8 1.7e+02 2.9 7.8 3.0 1 1 0 1 1 1 0 YtxH-like protein DUF948 PF06103.11 EDO08721.1 - 0.67 10.2 3.9 2.4 8.5 3.9 2.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF4337 PF14235.6 EDO08721.1 - 1.8 8.7 9.7 4.4 7.4 9.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF4407 PF14362.6 EDO08721.1 - 2.9 7.2 13.9 5.4 6.3 13.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Prominin PF05478.11 EDO08721.1 - 3.7 5.4 10.2 5.4 4.8 10.2 1.2 1 0 0 1 1 1 0 Prominin UPF0565 PF10561.9 EDO08721.1 - 8.9 5.4 10.9 54 2.8 10.8 2.1 1 1 0 1 1 1 0 Uncharacterised protein family UPF0565 SOGA PF11365.8 EDO08722.1 - 0.00066 20.8 3.7 0.00066 20.8 3.7 2.7 3 0 0 3 3 2 1 Protein SOGA TMF_TATA_bd PF12325.8 EDO08722.1 - 0.0044 17.2 4.6 0.0044 17.2 4.6 2.1 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding YscO PF07321.12 EDO08722.1 - 0.0063 16.5 0.7 0.0063 16.5 0.7 1.6 2 0 0 2 2 2 1 Type III secretion protein YscO Prefoldin_2 PF01920.20 EDO08722.1 - 0.0085 16.0 7.0 3.8 7.5 0.7 3.2 3 0 0 3 3 3 1 Prefoldin subunit CENP-F_leu_zip PF10473.9 EDO08722.1 - 0.016 15.2 12.3 0.62 10.1 0.1 3.1 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Laminin_II PF06009.12 EDO08722.1 - 0.017 15.2 2.9 0.017 15.2 2.9 2.1 2 0 0 2 2 2 0 Laminin Domain II SlyX PF04102.12 EDO08722.1 - 0.018 15.7 2.0 2.1 9.0 0.2 3.1 3 0 0 3 3 3 0 SlyX OmpH PF03938.14 EDO08722.1 - 0.039 14.3 1.2 0.09 13.1 0.2 2.0 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Seryl_tRNA_N PF02403.22 EDO08722.1 - 0.17 12.1 9.3 0.2 11.9 3.9 2.8 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ABC_tran_CTD PF16326.5 EDO08722.1 - 0.17 12.1 6.2 4.4 7.6 0.0 3.0 2 1 1 3 3 3 0 ABC transporter C-terminal domain DUF16 PF01519.16 EDO08722.1 - 0.26 11.8 4.5 0.47 11.0 0.3 2.6 3 0 0 3 3 3 0 Protein of unknown function DUF16 HIP1_clath_bdg PF16515.5 EDO08722.1 - 0.27 11.9 7.7 0.28 11.8 3.0 2.3 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF3618 PF12277.8 EDO08722.1 - 0.3 11.4 2.9 2.7 8.3 1.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3618) DUF2802 PF10975.8 EDO08722.1 - 0.32 11.2 2.4 1.1 9.4 0.2 2.5 2 1 1 3 3 2 0 Protein of unknown function (DUF2802) CCDC-167 PF15188.6 EDO08722.1 - 0.38 11.1 9.1 0.1 13.0 5.1 1.9 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 DUF1664 PF07889.12 EDO08722.1 - 0.4 10.7 6.2 1.2 9.2 3.4 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF5082 PF16888.5 EDO08722.1 - 0.52 10.6 7.4 2.6 8.4 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5082) Med21 PF11221.8 EDO08722.1 - 0.65 10.2 7.3 2.4 8.4 0.5 3.0 3 0 0 3 3 3 0 Subunit 21 of Mediator complex Allexi_40kDa PF05549.11 EDO08722.1 - 0.78 9.2 8.5 1.2 8.5 5.3 2.5 2 1 0 2 2 2 0 Allexivirus 40kDa protein Snapin_Pallidin PF14712.6 EDO08722.1 - 0.85 10.1 9.5 1.9 9.0 4.8 2.5 2 1 0 2 2 2 0 Snapin/Pallidin Lectin_N PF03954.14 EDO08722.1 - 0.94 9.2 4.7 0.37 10.6 0.5 2.2 2 1 1 3 3 2 0 Hepatic lectin, N-terminal domain DUF948 PF06103.11 EDO08722.1 - 0.96 9.7 5.7 0.3 11.4 1.8 2.1 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DivIC PF04977.15 EDO08722.1 - 0.97 9.3 4.8 7 6.5 0.2 3.0 3 0 0 3 3 3 0 Septum formation initiator TMPIT PF07851.13 EDO08722.1 - 1.6 7.9 4.6 7.5 5.7 2.5 2.0 2 0 0 2 2 2 0 TMPIT-like protein BST2 PF16716.5 EDO08722.1 - 2.9 8.5 6.9 1.1 9.9 3.1 2.0 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 Swi5 PF07061.11 EDO08722.1 - 2.9 8.0 9.4 1.5 8.9 2.3 3.0 2 1 1 3 3 3 0 Swi5 IFP_35_N PF07334.13 EDO08722.1 - 3.5 7.8 5.9 4.1 7.6 0.5 3.0 3 0 0 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus DUF4200 PF13863.6 EDO08722.1 - 3.6 8.0 9.5 3.8 7.9 0.8 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) Spc24 PF08286.11 EDO08722.1 - 4.3 7.6 13.6 11 6.3 1.3 3.3 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 NOA36 PF06524.12 EDO08722.1 - 4.9 6.4 10.8 6.4 6.0 10.8 1.3 1 0 0 1 1 1 0 NOA36 protein FlaC_arch PF05377.11 EDO08722.1 - 9.9 6.6 7.8 13 6.3 0.8 3.0 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Rad10 PF03834.14 EDO08723.1 - 1.3e-11 44.5 0.0 2e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.6 EDO08723.1 - 6.9e-07 29.8 0.1 1.9e-06 28.3 0.1 1.8 1 1 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.7 EDO08723.1 - 0.048 13.8 0.0 0.085 13.0 0.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix motif Ephrin_rec_like PF07699.13 EDO08725.1 - 2.1e-35 120.2 118.6 1.9e-08 33.9 0.2 12.2 11 2 1 12 12 12 10 Putative ephrin-receptor like DASH_Spc34 PF08657.10 EDO08725.1 - 0.0095 15.8 4.1 0.016 15.0 4.1 1.3 1 0 0 1 1 1 1 DASH complex subunit Spc34 Ephrin_rec_like PF07699.13 EDO08726.1 - 1.2e-29 101.8 119.9 3.4e-07 29.9 7.5 11.9 11 1 1 12 12 12 10 Putative ephrin-receptor like DivIC PF04977.15 EDO08726.1 - 0.34 10.7 1.7 1.2 9.0 1.4 2.0 2 0 0 2 2 2 0 Septum formation initiator NYD-SP28 PF14772.6 EDO08726.1 - 0.97 9.5 4.0 2.3 8.3 4.0 1.6 1 0 0 1 1 1 0 Sperm tail GTP_EFTU PF00009.27 EDO08727.1 - 5.5e-49 166.4 0.0 8.4e-49 165.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 EDO08727.1 - 1.3e-35 121.8 0.0 2.6e-35 120.8 0.0 1.6 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 EDO08727.1 - 5.4e-21 74.4 0.0 1.1e-20 73.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EDO08727.1 - 1.9e-05 24.9 0.2 5.4e-05 23.5 0.2 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDO08727.1 - 3.1e-05 24.0 0.0 5.5e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 EDO08727.1 - 0.001 19.1 0.1 0.0057 16.7 0.0 2.3 2 1 0 2 2 2 1 Elongation Factor G, domain II RF3_C PF16658.5 EDO08727.1 - 0.025 14.4 0.0 0.045 13.6 0.0 1.4 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain TniB PF05621.11 EDO08727.1 - 0.066 12.6 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein Ras PF00071.22 EDO08727.1 - 0.083 12.5 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 Ras family Porin_3 PF01459.22 EDO08728.1 - 2.3e-26 92.9 0.1 8.8e-26 91.0 0.1 1.7 1 1 0 1 1 1 1 Eukaryotic porin Patatin PF01734.22 EDO08730.1 - 4.2e-08 33.6 0.2 8.3e-08 32.6 0.2 1.5 1 1 0 1 1 1 1 Patatin-like phospholipase Aconitase PF00330.20 EDO08731.1 - 2.2e-169 564.4 0.0 2.9e-169 563.9 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EDO08731.1 - 1.6e-41 141.7 0.0 2.6e-41 141.0 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Ribosomal_L2_C PF03947.18 EDO08732.1 - 2.1e-44 150.8 2.3 3e-44 150.2 2.3 1.2 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EDO08732.1 - 1.6e-15 56.8 0.9 4.2e-15 55.5 0.9 1.8 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain RNase_PH PF01138.21 EDO08733.1 - 3.7e-17 63.1 0.0 4.8e-17 62.7 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 PSRP-3_Ycf65 PF04839.13 EDO08734.1 - 0.099 12.9 0.1 0.2 11.9 0.1 1.4 1 0 0 1 1 1 0 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65) GCP_N_terminal PF17681.1 EDO08734.1 - 0.1 12.2 0.1 1.3 8.6 0.1 2.2 1 1 0 1 1 1 0 Gamma tubulin complex component N-terminal TagF_N PF09867.9 EDO08734.1 - 0.16 12.0 0.0 7.4 6.6 0.0 2.5 2 0 0 2 2 2 0 TagF N-terminal domain, Type VI secretion system-associated Yos1 PF08571.10 EDO08735.1 - 2.4e-17 63.0 3.6 3e-17 62.6 3.6 1.1 1 0 0 1 1 1 1 Yos1-like tRNA-synt_1c PF00749.21 EDO08736.1 - 1.7e-99 332.7 0.0 2.2e-99 332.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EDO08736.1 - 4.3e-37 127.7 0.0 1.6e-36 125.8 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C_3 PF14497.6 EDO08736.1 - 0.0026 17.9 0.0 0.041 14.1 0.0 2.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EDO08736.1 - 0.0042 17.3 0.0 0.014 15.6 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Ub-Mut7C PF14451.6 EDO08736.1 - 0.18 11.7 0.0 0.43 10.5 0.0 1.6 1 0 0 1 1 1 0 Mut7-C ubiquitin Barttin PF15462.6 EDO08737.1 - 0.1 12.4 1.4 0.22 11.3 0.1 2.0 2 0 0 2 2 2 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) HIT PF01230.23 EDO08739.1 - 9.7e-26 90.4 0.2 1.2e-25 90.0 0.2 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EDO08739.1 - 1.8e-20 73.5 0.1 2.4e-20 73.1 0.1 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CDH PF02611.15 EDO08739.1 - 0.027 14.1 0.1 0.059 13.0 0.1 1.5 1 1 0 1 1 1 0 CDP-diacylglycerol pyrophosphatase Recombinase PF07508.13 EDO08740.1 - 0.12 12.7 0.5 0.68 10.4 0.0 2.4 2 0 0 2 2 2 0 Recombinase LRR_adjacent PF08191.11 EDO08744.1 - 0.067 13.4 0.1 0.16 12.2 0.1 1.6 1 0 0 1 1 1 0 LRR adjacent Abhydrolase_9_N PF15420.6 EDO08744.1 - 8 6.4 11.3 4.3 7.3 4.5 2.6 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus F-box-like_2 PF13013.6 EDO08745.1 - 0.00019 21.4 6.1 0.12 12.3 0.4 3.4 1 1 2 3 3 3 2 F-box-like domain Band_7 PF01145.25 EDO08745.1 - 0.0042 17.1 0.0 2.1 8.4 0.0 3.1 2 1 0 2 2 2 2 SPFH domain / Band 7 family DUF2014 PF09427.10 EDO08745.1 - 0.009 15.4 0.1 0.69 9.2 0.0 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF2014) O_Spanin_T7 PF17531.2 EDO08745.1 - 0.029 14.4 0.1 0.31 11.1 0.2 2.3 2 0 0 2 2 2 0 outer-membrane spanin sub-unit Mis14 PF08641.12 EDO08745.1 - 0.21 11.9 4.1 19 5.5 0.1 3.6 4 1 0 4 4 4 0 Kinetochore protein Mis14 like VESA1_N PF12785.7 EDO08746.1 - 1.8e-223 742.5 29.5 1.8e-223 742.5 29.5 2.6 3 0 0 3 3 3 1 Variant erythrocyte surface antigen-1 Lipoprotein_6 PF01441.19 EDO08746.1 - 3.3 7.7 8.7 0.59 10.1 3.1 2.5 3 0 0 3 3 3 0 Lipoprotein VESA1_N PF12785.7 EDO08747.1 - 2.7e-18 66.2 45.7 2.3e-11 43.3 0.3 4.6 4 1 1 5 5 5 3 Variant erythrocyte surface antigen-1 F-box-like_2 PF13013.6 EDO08748.1 - 2.7e-09 37.0 1.8 8.3e-07 29.0 0.6 2.2 1 1 1 2 2 2 2 F-box-like domain VESA1_N PF12785.7 EDO08749.1 - 7.2e-09 35.1 12.5 1.3e-08 34.3 12.5 1.3 1 1 0 1 1 1 1 Variant erythrocyte surface antigen-1 Cytochrom_B558a PF05038.13 EDO08750.1 - 3 7.4 5.5 0.99 8.9 1.6 2.1 2 0 0 2 2 2 0 Cytochrome Cytochrome b558 alpha-subunit # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Babesia_bovis-ASM16539v1/GCA_000165395.1_ASM16539v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Babesia_bovis-ASM16539v1/GCA_000165395.1_ASM16539v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Babesia_bovis-ASM16539v1/GCA_000165395.1_ASM16539v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Babesia_bovis-ASM16539v1/GCA_000165395.1_ASM16539v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 00:28:00 2019 # [ok]