# species: Homo sapiens # support: EXP, IMP, ISS, ISM, TAS, IEA, HMP, HEP, IDA, IGI, ISO, IGC, NAS, HGI, IPI, IEP, ISA, RCA, IC, HDA # associations retrieved on: 2019-10-08 13:20:05-04 # gofunc built on: 2018-02-21 10:04:34.764444-05 # gene associations file: ftp://ftp.geneontology.org/pub/go/gene-associations/goa_human.gaf.gz # revision: 2018-02-02 $ # downloaded on: 2018-02-14 09:47:26-05 # GO DAG files from: http://archive.geneontology.org/latest-full/go_201512-termdb-tables.tar.gz # downloaded on: 2015-12-22 05:43:21-05 # translation required: yes # translation info: # authority: ensembl # synergizer db built on: 2015-11-17 14:24:21.26681-05 # synergizer db built from: Ensembl Genes 82 / Metazoa Mart / Plant Mart # namespace: hgnc_symbol # coverage: 99.8% # size of "genespace": 18224 # number of attributes: 20270 # NOTE: the last record consists of all the entities in the # "genespace" that are not associated with any attribute (for # the requested support). # Original number of entities in query: 2146 # Number of entities in query: 2146 # Total number of entities: 18442 # Original total number of entities: 18224 # Entities not in default gene space: 218 # Total number of attributes: 20270 # Translation required: yes # Translation coverage: 0.997782 # Mode: unordered # Number of simulations: 1000 # Adjusted P-value cutoff: 0.05 # Over/under: over # Evidence codes: EXP, IMP, ISS, ISM, TAS, IEA, HMP, HEP, IDA, IGI, ISO, IGC, NAS, HGI, IPI, IEP, ISA, RCA, IC, HDA OVERREPRESENTED ATTRIBUTES N X LOD P P_adj attrib ID attrib name 16 38 0.748327542220949 1.91905725088764e-06 0.005 GO:0008287 protein serine/threonine phosphatase complex 16 38 0.748327542220949 1.91905725088764e-06 0.005 GO:1903293 phosphatase complex 24 59 0.723250635870234 1.22734016013748e-08 <0.001 GO:0019003 GDP binding 17 47 0.641754682451449 1.08523880258437e-05 0.043 GO:0030117 membrane coat 29 84 0.610331750312065 3.16550182009498e-08 <0.001 GO:0070125 mitochondrial translational elongation 20 59 0.598545141059188 5.84993628721507e-06 0.015 GO:0004722 protein serine/threonine phosphatase activity 28 86 0.572206435235256 2.23749015893805e-07 <0.001 GO:0070126 mitochondrial translational termination 23 71 0.569087133085899 2.90818306744503e-06 0.011 GO:0031124 mRNA 3'-end processing 26 81 0.563140750477725 8.17291944289181e-07 0.002 GO:0071013 catalytic step 2 spliceosome 21 66 0.557859406141516 1.06466524390601e-05 0.04 GO:0006369 termination of RNA polymerase II transcription 29 93 0.544824293884944 3.86191887054041e-07 0.001 GO:0006415 translational termination 45 146 0.53841032049468 4.07526037766739e-10 <0.001 GO:0043209 myelin sheath 25 86 0.501487696565488 9.71523534070056e-06 0.037 GO:0031123 RNA 3'-end processing 31 108 0.493633283662019 1.18038036128054e-06 0.002 GO:0006414 translational elongation 29 103 0.481960107057917 3.948058516711e-06 0.012 GO:0006353 DNA-templated transcription, termination 34 122 0.475821932097888 7.80661388349404e-07 0.001 GO:0043624 cellular protein complex disassembly 66 241 0.467782251978819 1.44883450455949e-11 <0.001 GO:0010498 proteasomal protein catabolic process 39 142 0.467229888152877 1.89331451711075e-07 <0.001 GO:0005681 spliceosomal complex 63 231 0.464974293838686 5.07782088808973e-11 <0.001 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 60 223 0.456547822023255 2.62703260345822e-10 <0.001 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 60 223 0.456547822023255 2.62703260345822e-10 <0.001 GO:0000398 mRNA splicing, via spliceosome 61 229 0.450658994933574 2.89713466158131e-10 <0.001 GO:0000375 RNA splicing, via transesterification reactions 52 196 0.447450841328358 6.79601906383796e-09 <0.001 GO:0000151 ubiquitin ligase complex 38 144 0.443397777359084 8.1171040650379e-07 0.002 GO:0043241 protein complex disassembly 40 155 0.430330353092111 7.89574531968084e-07 0.002 GO:0032984 macromolecular complex disassembly 37 145 0.42362860942468 2.69266211594186e-06 0.008 GO:0043488 regulation of mRNA stability 41 163 0.415387626520432 1.19159392608024e-06 0.002 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 37 148 0.411702990730427 4.52199509262673e-06 0.013 GO:0043487 regulation of RNA stability 92 372 0.410070339616991 1.00149849815972e-12 <0.001 GO:0019941 modification-dependent protein catabolic process 48 194 0.40618111247321 2.58552901975555e-07 0.001 GO:1903322 positive regulation of protein modification by small protein conjugation or removal 44 178 0.405410260061005 8.25449863215544e-07 0.002 GO:0031398 positive regulation of protein ubiquitination 90 367 0.40490583467889 2.93688055949977e-12 <0.001 GO:0006511 ubiquitin-dependent protein catabolic process 92 376 0.403812459162795 1.92589409681237e-12 <0.001 GO:0043632 modification-dependent macromolecule catabolic process 78 321 0.398284898341051 1.33523066983787e-10 <0.001 GO:0030163 protein catabolic process 41 169 0.394459454268489 3.21038603137998e-06 0.011 GO:0044455 mitochondrial membrane part 43 178 0.392089111946766 2.10607523326017e-06 0.007 GO:1903364 positive regulation of cellular protein catabolic process 43 179 0.388868882784806 2.46433008291919e-06 0.007 GO:0016241 regulation of macroautophagy 98 412 0.388024325533065 2.20502490798388e-12 <0.001 GO:0051603 proteolysis involved in cellular protein catabolic process 78 337 0.37021343871223 1.51193703690048e-09 <0.001 GO:0008380 RNA splicing 59 255 0.368367290090157 1.4788929450428e-07 <0.001 GO:0003924 GTPase activity 57 248 0.364430903070692 3.0252870837016e-07 0.001 GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 51 224 0.35867940668589 1.67759688627282e-06 0.003 GO:0006913 nucleocytoplasmic transport 90 402 0.352368899637192 5.22217955962468e-10 <0.001 GO:0006397 mRNA processing 56 249 0.352037584193147 8.06598796950766e-07 0.002 GO:0045732 positive regulation of protein catabolic process 57 256 0.346441002951381 9.10253057294071e-07 0.002 GO:0000209 protein polyubiquitination 51 229 0.346205966994312 3.32028875070071e-06 0.011 GO:0051169 nuclear transport 67 303 0.343272764787246 1.37219456994285e-07 <0.001 GO:0004842 ubiquitin-protein transferase activity 60 272 0.341385616262678 6.62680433534769e-07 0.001 GO:1903362 regulation of cellular protein catabolic process 112 515 0.33807083545123 2.69186988278212e-11 <0.001 GO:1990234 transferase complex 71 326 0.335037375238804 1.10287137825935e-07 <0.001 GO:0019787 ubiquitin-like protein transferase activity 92 434 0.321658209648337 6.25350652907078e-09 <0.001 GO:0019866 organelle inner membrane 167 813 0.311418992952115 6.19412214642023e-14 <0.001 GO:1902494 catalytic complex 75 361 0.308942282624522 3.60626407655073e-07 0.001 GO:0005525 GTP binding 81 391 0.307824196924405 1.41046200718465e-07 <0.001 GO:0042176 regulation of protein catabolic process 82 396 0.307663124663818 1.20592534302996e-07 <0.001 GO:0005743 mitochondrial inner membrane 133 651 0.304846585197825 3.71823051892106e-11 <0.001 GO:0044265 cellular macromolecule catabolic process 78 379 0.303924635190534 3.16283147648706e-07 0.001 GO:0032561 guanyl ribonucleotide binding 78 380 0.302459420788122 3.53508590154532e-07 0.001 GO:0019001 guanyl nucleotide binding 133 661 0.296275022554427 1.09680584956786e-10 <0.001 GO:0016567 protein ubiquitination 130 650 0.292602213267344 2.70678254168957e-10 <0.001 GO:1990904 ribonucleoprotein complex 129 647 0.290773178463844 3.91423799749229e-10 <0.001 GO:0030529 intracellular ribonucleoprotein complex 68 338 0.290611961085577 4.05066077426702e-06 0.012 GO:0005759 mitochondrial matrix 116 581 0.290325311482779 2.81626214847865e-09 <0.001 GO:0031966 mitochondrial membrane 146 736 0.289558585672545 3.83935531675677e-11 <0.001 GO:0032446 protein modification by small protein conjugation 181 924 0.285950741891182 4.80709624308855e-13 <0.001 GO:0044429 mitochondrial part 79 401 0.27981916513678 1.63872538762898e-06 0.003 GO:0009896 positive regulation of catabolic process 111 579 0.267333926006052 6.08074697800671e-08 <0.001 GO:0016071 mRNA metabolic process 89 463 0.267042626953818 1.09757502630362e-06 0.002 GO:0016032 viral process 89 463 0.267042626953818 1.09757502630362e-06 0.002 GO:0044403 symbiosis, encompassing mutualism through parasitism 179 946 0.266228800800842 1.44284561002858e-11 <0.001 GO:0070647 protein modification by small protein conjugation or removal 79 413 0.263626398599516 5.2551445730611e-06 0.013 GO:0010608 posttranscriptional regulation of gene expression 90 478 0.255758074513665 2.36172396570943e-06 0.007 GO:0044764 multi-organism cellular process 120 647 0.249835898332904 1.17874252184417e-07 <0.001 GO:0034622 cellular macromolecular complex assembly 124 670 0.248984999894914 8.18908708842404e-08 <0.001 GO:0016462 pyrophosphatase activity 124 670 0.248984999894914 8.18908708842404e-08 <0.001 GO:0016817 hydrolase activity, acting on acid anhydrides 124 670 0.248984999894914 8.18908708842404e-08 <0.001 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 145 790 0.246167117835309 1.11009582368825e-08 <0.001 GO:0009057 macromolecule catabolic process 270 1534 0.2339310795306 4.07609662609521e-13 <0.001 GO:0003723 RNA binding 113 630 0.230934568399822 1.53405313171431e-06 0.002 GO:0017111 nucleoside-triphosphatase activity 223 1281 0.223436693849643 1.6856704994793e-10 <0.001 GO:0046907 intracellular transport 138 793 0.216283640317309 6.35905258611265e-07 0.001 GO:0009894 regulation of catabolic process 177 1025 0.215076842793352 2.74152388442503e-08 <0.001 GO:0015031 protein transport 118 687 0.207709303747702 7.83918921534558e-06 0.023 GO:0031329 regulation of cellular catabolic process 130 763 0.20415447752719 4.14835720444369e-06 0.012 GO:0006396 RNA processing 182 1078 0.202995362824223 9.04822860178428e-08 <0.001 GO:1902582 single-organism intracellular transport 201 1195 0.202401416048138 2.45638940343865e-08 <0.001 GO:0005739 mitochondrion 129 762 0.20059841721969 6.27303805820799e-06 0.016 GO:0080135 regulation of cellular response to stress 184 1101 0.197522848583266 1.59099552242832e-07 <0.001 GO:0045184 establishment of protein localization 134 797 0.197201686073945 5.95314903948636e-06 0.015 GO:0016482 cytoplasmic transport 219 1342 0.186952830111119 6.83455186167251e-08 <0.001 GO:0065003 macromolecular complex assembly 182 1130 0.177039438959295 2.2542377295506e-06 0.007 GO:0006461 protein complex assembly 238 1494 0.174896000159502 1.35884662738917e-07 <0.001 GO:0071822 protein complex subunit organization 231 1449 0.174801445846011 2.00001946693758e-07 <0.001 GO:0008104 protein localization 233 1462 0.174771085406826 1.80558731275005e-07 <0.001 GO:0033036 macromolecule localization 465 3064 0.163974301003856 5.20495788827213e-11 <0.001 GO:0031090 organelle membrane 468 3090 0.16298420834923 5.98737147666086e-11 <0.001 GO:0005654 nucleoplasm 329 2143 0.160467564033473 2.1423575799554e-08 <0.001 GO:0043933 macromolecular complex subunit organization 613 4167 0.156606910441008 3.84124595704619e-12 <0.001 GO:0044428 nuclear part 1050 7582 0.155958012082948 4.3824931924208e-15 <0.001 GO:0043231 intracellular membrane-bounded organelle 1663 13217 0.149882509429637 4.85692402036076e-11 <0.001 GO:0044424 intracellular part 1148 8480 0.148056930227873 7.20365715101316e-14 <0.001 GO:0044446 intracellular organelle part 684 4767 0.146085154534651 1.70558780104167e-11 <0.001 GO:0005829 cytosol 1163 8648 0.1438210542296 3.50082529191363e-13 <0.001 GO:0043229 intracellular organelle 1106 8209 0.138717829326278 2.21562174407758e-12 <0.001 GO:0044237 cellular metabolic process 654 4621 0.134423840604263 8.46415723022439e-10 <0.001 GO:0032991 macromolecular complex 1159 8708 0.133699410377632 1.2488098891219e-11 <0.001 GO:0044422 organelle part 1197 9049 0.132346547975629 2.10606733957823e-11 <0.001 GO:0043227 membrane-bounded organelle 877 6384 0.131661233461783 8.67587896618865e-11 <0.001 GO:0044260 cellular macromolecule metabolic process 409 2867 0.122747898289284 1.76625667514291e-06 0.003 GO:0006464 cellular protein modification process 409 2867 0.122747898289284 1.76625667514291e-06 0.003 GO:0036211 protein modification process 513 3648 0.120419892118153 3.29145687809699e-07 0.001 GO:0003676 nucleic acid binding 446 3159 0.11872668813062 1.67475572092133e-06 0.003 GO:0044267 cellular protein metabolic process 1179 9048 0.115798593012537 3.88947277811328e-09 <0.001 GO:0044444 cytoplasmic part 550 3973 0.112814705579179 8.52227938684631e-07 0.002 GO:0043234 protein complex 634 4630 0.110979191128135 3.85338311432345e-07 0.001 GO:0005634 nucleus 1291 10094 0.108903739707676 3.98224421053381e-08 <0.001 GO:0043226 organelle 735 5471 0.104420870981092 5.72340054317379e-07 0.001 GO:1901363 heterocyclic compound binding 573 4216 0.10235857054773 5.10770057146093e-06 0.013 GO:0006139 nucleobase-containing compound metabolic process 740 5538 0.100921016768798 1.22463060893467e-06 0.002 GO:0097159 organic cyclic compound binding 595 4402 0.100035126228839 6.21838527119889e-06 0.016 GO:0046483 heterocycle metabolic process 1159 9039 0.0983114030628511 4.7600929528596e-07 0.001 GO:0008152 metabolic process 1051 8239 0.0850054807142695 1.16550036599062e-05 0.045 GO:0044238 primary metabolic process 1095 8619 0.0844488352308926 1.27927565330473e-05 0.049 GO:0071704 organic substance metabolic process