Dear Reviewers,

Please find the raw FASTQ files, associated with our manuscript "Spatially Decoding Genotype-Associated Epigenetic Landscape in Human Lymphoma FFPE Tissues via epi-Patho-DBiT".

These files are available in the following six folders within the provided Box directory:
1. Folder "mouse_brain_coronal_ATAC": Mouse brain coronal FFPE section for spatial-FFPE-ATAC at a resolution of 50um
2. Folder "mouse_colon_ATAC": Mouse colon FFPE section for spatial-FFPE-ATAC at a resolution of 50um
3. Folder "mouse_brain_sagittal_ATAC": Mouse brain sagittal FFPE section for spatial-FFPE-ATAC at a resolution of 50um
4. Folder "human_MALT_ATAC": Human MALT FFPE section for spatial-FFPE-ATAC at a resolution of 20um
5. Folder "human_DLBCL_H3K27me3": Human DLBCL FFPE section for spatial-FFPE-CUT&Tag at a resolution of 50um
6. Folder "human_DLBCL_Patho_DBiT": Human DLBCL FFPE section for Patho-DBiT at a resolution of 50um

Please note that these data are shared solely for review purposes and may include sensitive patient genomic information. They remain confidential until the manuscript is published. The raw and processed data have been deposited in GEO prior to submission (GSE288178) and will be publicly accessible upon publication.

Additionally, we have developed a portal for interactive exploration of the spatial gene activity profile of the mouse brain data (related to Fig 2) (Accession: SCP3101 | URL: https://singlecell.broadinstitute.org/single_cell/reviewer_access/bd68fbe1-02bc-4c86-8986-f0acdf1f1742 | reviewer access PIN: LJBMJZIUL1), which will also be publicly accessible upon publication.

We hope these resources support your evaluation. Thank you very much for your time and consideration!!

Sincerely,
The Fan Lab