# Filepaths and Hard-coded Defaults
proj_root = "/users/kcochran/projects/procap_models/"
sequence_path = proj_root + "genomes/GRCh38_no_alt_analysis_set_GCA_000001405.15.fasta"
chrom_sizes = proj_root + "genomes/hg38.chrom.sizes.withrRNA"
in_window = 2114
out_window = 1000
# stuff to get from config file
with open("2022-07-03_11-35-25_run1_modisco_config_CACO2_profile.txt") as config_f:
config_dict = {line.split()[0] : line.strip().split()[1] for line in config_f}
modisco_out_path = config_dict["modisco_out_path"]
scoring_type = config_dict["scoring_type"]
score_center_size = int(config_dict["score_center_size"])
profile_display_center_size = int(config_dict["profile_display_center_size"])
# digest what's in config file
assay_type, model_type, cell, accession, modisco_dir_base = modisco_out_path.split("/")[-5:]
ts_part1, ts_part2, run_str, _ = modisco_dir_base.split("_")
timestamp = ts_part1 + "_" + ts_part2
run = int(run_str.replace("run", ""))
print(modisco_out_path)
print("cell_type:", cell, accession)
print("timestamp:", timestamp)
print("run:", run)
print("scoring_type:", scoring_type)
print("score_center_size:", score_center_size)
print("profile_display_center_size:", profile_display_center_size)
/users/kcochran//projects/procap_models/modisco_out/procap/bpnetlite_basic_v2/CACO2/ENCSR100LIJ/2022-07-03_11-35-25_run1_modisco cell_type: CACO2 ENCSR100LIJ timestamp: 2022-07-03_11-35-25 run: 1 scoring_type: profile score_center_size: 1000 profile_display_center_size: 400
data_dir = proj_root + "/data/procap/processed/" + cell + "/" + accession + "/"
plus_bw_path = data_dir + "final.5prime.pos.bigWig"
minus_bw_path = data_dir + "final.5prime.neg.bigWig"
val_peak_path = data_dir + "peaks_uni_and_bi_train_and_val.bed.gz"
val_save_dir = proj_root + "model_out/" + assay_type + "/" + model_type + "/" + cell + "/" + accession + "/"
val_save_path = val_save_dir + timestamp + "_run" + str(run) + "_train_and_val"
attr_save_path = val_save_dir.replace("model_out", "deepshap_out") + timestamp + "_run" + str(run) + "_deepshap"
if not modisco_out_path.endswith("/"):
modisco_out_path = modisco_out_path + "/"
# task-specific filepaths
import os
assert scoring_type in ["profile", "counts"], scoring_type
if scoring_type == "profile":
scores_path = attr_save_path + "_prof.npy"
onehot_scores_path = attr_save_path + "_prof_onehot.npy"
modisco_obj_path = modisco_out_path + "results_allChroms_prof_slice" + str(score_center_size) + ".hdf5"
seqlet_path = modisco_out_path + "seqlets_prof.txt"
else:
scores_path = attr_save_path + "_count.npy"
onehot_scores_path = attr_save_path + "_count_onehot.npy"
modisco_obj_path = modisco_out_path + "results_allChroms_count_slice" + str(score_center_size) + ".hdf5"
seqlet_path = modisco_out_path + "seqlets_count.txt"
assert(os.path.exists(scores_path)), scores_path
assert(os.path.exists(onehot_scores_path)), onehot_scores_path
# Imports, Plotting Defaults
import matplotlib.pyplot as plt
import matplotlib.font_manager as font_manager
plot_params = {
"figure.titlesize": 22,
"axes.titlesize": 22,
"axes.labelsize": 20,
"legend.fontsize": 18,
"xtick.labelsize": 16,
"ytick.labelsize": 16,
"font.weight": "bold"
}
plt.rcParams.update(plot_params)
from IPython.display import display
import tqdm
tqdm.tqdm_notebook()
import numpy as np
from view_modisco_results_utils import *
/users/kcochran/miniconda3/envs/procap/lib/python3.7/site-packages/ipykernel_launcher.py:19: TqdmDeprecationWarning: This function will be removed in tqdm==5.0.0 Please use `tqdm.notebook.tqdm` instead of `tqdm.tqdm_notebook`
# Load in True Profiles and Sequences
import sys
sys.path.append('../1_train_models')
from data_loading import extract_peaks
one_hot_seqs, true_profs = extract_peaks(sequence_path,
plus_bw_path, minus_bw_path, val_peak_path, in_window, out_window,
max_jitter=0, verbose=True)
one_hot_seqs = one_hot_seqs.swapaxes(1,2)
one_hot_seqs = one_hot_seqs[:, (in_window // 2 - score_center_size // 2):(in_window // 2 + score_center_size // 2), :]
Reading FASTA: 100%|██████████████████████████████████████████████████████████████████████████████████████████████████████████████████████████████████████████████████████████████████████████████████████████████████████████| 24/24 [00:15<00:00, 1.53it/s] Loading Peaks: 42149it [01:23, 504.23it/s]
# Load in Coordinates of Examples
coords = load_coords(val_peak_path, in_window)
# Import SHAP scores, predicted profiles
hyp_scores = np.load(scores_path).swapaxes(1,2)
hyp_scores = hyp_scores[:, (in_window // 2 - score_center_size // 2):(in_window // 2 + score_center_size // 2), :]
pred_profs = np.exp(np.load(val_save_path + ".profs.npy"))
# Load modisco results object
tfm_obj = import_tfmodisco_results(modisco_obj_path, hyp_scores, one_hot_seqs)
motif_pfms, motif_hcwms, motif_cwms, \
motif_pfms_short, num_seqlets, \
motif_seqlets, num_metaclusters = plot_all_metaclusters(tfm_obj, one_hot_seqs, hyp_scores,
true_profs, pred_profs, coords,
in_window, out_window,
score_center_size,
profile_display_center_size)
16401 seqlets
Sequence (PFM) | |
Hypothetical contributions (hCWM) | |
Actual contributions (CWM) |
5452 seqlets
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4969 seqlets
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4868 seqlets
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3588 seqlets
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3413 seqlets
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2273 seqlets
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2123 seqlets
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1993 seqlets
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1957 seqlets
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1669 seqlets
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1213 seqlets
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1149 seqlets
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1124 seqlets
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897 seqlets
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826 seqlets
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759 seqlets
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559 seqlets
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541 seqlets
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540 seqlets
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471 seqlets
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434 seqlets
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366 seqlets
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360 seqlets
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353 seqlets
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288 seqlets
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259 seqlets
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212 seqlets
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199 seqlets
Sequence (PFM) | |
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190 seqlets
Sequence (PFM) | |
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185 seqlets
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185 seqlets
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66 seqlets
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56 seqlets
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52 seqlets
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51 seqlets
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51 seqlets
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49 seqlets
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48 seqlets
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47 seqlets
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35 seqlets
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26 seqlets
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25 seqlets
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run_and_plot_tomtom(modisco_out_path, motif_pfms, motif_hcwms, motif_pfms_short, num_metaclusters)
The output directory '/users/kcochran//projects/procap_models/modisco_out/procap/bpnetlite_basic_v2/CACO2/ENCSR100LIJ/2022-07-03_11-35-25_run1_modisco/tomtom' already exists. Its contents will be overwritten. Processing query 1 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=1 Processing query 2 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.972149 Processing query 3 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.998346 Processing query 4 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=1 Processing query 5 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.956394 Processing query 6 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=1 Processing query 7 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.961768 Processing query 8 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.988758 Processing query 9 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.967197 Processing query 10 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.986014 Processing query 11 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=1 Processing query 12 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=1 Processing query 13 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.983959 Processing query 14 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.963844 Processing query 15 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.967376 Processing query 16 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.985243 Processing query 17 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.973244 Processing query 18 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.986604 Processing query 19 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=1 Processing query 20 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=1 Processing query 21 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.99552 Processing query 22 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=1 Processing query 23 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.993576 Processing query 24 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.97421 Processing query 25 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.998602 Processing query 26 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.955021 Processing query 27 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=1 Processing query 28 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.974727 Processing query 29 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.963201 Processing query 30 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.961092 Processing query 31 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.968775 Processing query 32 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.964181 Processing query 33 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=1 Processing query 34 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=1 Processing query 35 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.962674 Processing query 36 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.978711 Processing query 37 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=1 Processing query 38 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=1 Processing query 39 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.982215 Processing query 40 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.979317 Processing query 41 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.995125 Processing query 42 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=1 Processing query 43 out of 43 Estimating pi_0 from all 3912 observed p-values. Estimating pi_0. Estimated pi_0=0.988154 Can't locate HtmlMonolithWr.pm: /root/lib/perl/HtmlMonolithWr.pm: Permission denied at /software/meme/4.11.2/bin/tomtom_xml_to_html line 48. Warning: tomtom_xml_to_html exited abnormally and may have failed to create HTML output.
No TOMTOM matches passing threshold
Motif ID | q-val | PWM |
---|---|---|
MA0742.2-KLF12 | 0.000158461 | |
MA0516.3-SP2 | 0.000158461 | |
MA0685.2-SP4 | 0.000158461 | |
MA1511.2-KLF10 | 0.000158461 | |
MA0741.1-KLF16 | 0.000163241 |
No TOMTOM matches passing threshold
Motif ID | q-val | PWM |
---|---|---|
MA0060.3-NFYA | 1.03745e-05 | |
MA1644.1-NFYC | 1.03745e-05 | |
MA0314.2-HAP3 | 1.03745e-05 | |
MA0316.1-HAP5 | 0.00902935 | |
MA0502.2-NFYB | 0.00902935 |
Motif ID | q-val | PWM |
---|---|---|
MA1475.1-CREB3L4 | 0.00109599 | |
MA1438.1-atf-7 | 0.00208936 | |
MA0609.2-CREM | 0.00208936 | |
MA1348.1-TGA9 | 0.00332866 | |
MA1346.1-TGA10 | 0.00332866 |
No TOMTOM matches passing threshold
Motif ID | q-val | PWM |
---|---|---|
MA1832.1-Zm00001d002364 | 9.8738e-09 | |
MA1817.1-Zm00001d020267 | 3.84147e-08 | |
MA1821.1-Zm00001d020595 | 7.56045e-08 | |
MA1833.1-Zm00001d049364 | 7.56045e-08 | |
MA1819.1-Zm00001d005892 | 1.87445e-07 |
Motif ID | q-val | PWM |
---|---|---|
MA0506.2-Nrf1 | 0.0036152 | |
MA1650.1-ZBTB14 | 0.0675921 | |
MA1880.1-Hey | 0.0735238 | |
MA1816.1-O11 | 0.168551 | |
MA1833.1-Zm00001d049364 | 0.168551 |
Motif ID | q-val | PWM |
---|---|---|
MA1832.1-Zm00001d002364 | 2.7108e-05 | |
MA1821.1-Zm00001d020595 | 2.7108e-05 | |
MA1818.1-Zm00001d052229 | 7.99929e-05 | |
MA1819.1-Zm00001d005892 | 0.000692292 | |
MA1833.1-Zm00001d049364 | 0.000899951 |
Motif ID | q-val | PWM |
---|---|---|
MA0750.2-ZBTB7A | 1.02456e-05 | |
MA0076.2-ELK4 | 3.30479e-05 | |
MA0759.2-ELK3 | 0.000203723 | |
MA0156.3-FEV | 0.000203723 | |
MA0763.1-ETV3 | 0.000203723 |
Motif ID | q-val | PWM |
---|---|---|
MA1628.1-Zic1::Zic2 | 0.455417 | |
MA1726.1-ZNF331 | 0.455417 | |
MA1722.1-ZSCAN31 | 0.455417 |
Motif ID | q-val | PWM |
---|---|---|
MA0808.1-TEAD3 | 0.00301317 | |
MA1121.1-TEAD2 | 0.00903948 | |
MA0809.2-TEAD4 | 0.0476454 | |
MA0090.3-TEAD1 | 0.0476454 | |
MA0243.1-sd | 0.077189 |
Motif ID | q-val | PWM |
---|---|---|
MA1890.1-Klf15 | 1.41023e-07 | |
MA1892.1-Klf5-like | 1.03988e-05 | |
MA1893.1-Klf6-7-like | 1.03988e-05 | |
MA1961.1-PATZ1 | 0.00067257 | |
MA1653.1-ZNF148 | 0.00109176 |
Motif ID | q-val | PWM |
---|---|---|
MA1833.1-Zm00001d049364 | 6.41262e-08 | |
MA2022.1-LOB | 1.33291e-06 | |
MA1817.1-Zm00001d020267 | 4.35124e-06 | |
MA1820.1-Zm00001d024324 | 9.81509e-06 | |
MA1819.1-Zm00001d005892 | 9.81509e-06 |
Motif ID | q-val | PWM |
---|---|---|
MA0139.1-CTCF | 3.92434e-09 | |
MA1102.2-CTCFL | 8.11769e-07 | |
MA1929.1-CTCF | 9.87725e-07 | |
MA1930.1-CTCF | 5.28165e-06 | |
MA0531.1-CTCF | 7.38485e-05 |
Motif ID | q-val | PWM |
---|---|---|
MA0489.2-Jun | 0.0019904 | |
MA1988.1-Atf3 | 0.0019904 | |
MA1448.1-fos-1 | 0.0019904 | |
MA0099.3-FOS::JUN | 0.00251172 | |
MA1928.1-BNC2 | 0.00251172 |
Motif ID | q-val | PWM |
---|---|---|
MA0153.2-HNF1B | 4.57794e-07 | |
MA0046.2-HNF1A | 4.80425e-07 | |
MA1198.1-HAT2 | 0.122134 | |
MA1212.1-ATHB-13 | 0.122134 | |
MA0951.1-ATHB-16 | 0.18482 |
Motif ID | q-val | PWM |
---|---|---|
MA1893.1-Klf6-7-like | 0.103622 | |
MA0742.2-KLF12 | 0.103622 | |
MA0079.5-SP1 | 0.103622 | |
MA1511.2-KLF10 | 0.103622 | |
MA0740.2-KLF14 | 0.108232 |
Motif ID | q-val | PWM |
---|---|---|
MA0527.1-ZBTB33 | 2.15706e-13 |
Motif ID | q-val | PWM |
---|---|---|
MA1573.2-Thap11 | 5.31448e-08 | |
MA0088.2-ZNF143 | 0.0199755 | |
MA1716.1-ZNF76 | 0.0285848 | |
MA1625.1-Stat5b | 0.315818 | |
MA0519.1-Stat5a::Stat5b | 0.406725 |
Motif ID | q-val | PWM |
---|---|---|
MA0114.4-HNF4A | 0.00161612 | |
MA0484.2-HNF4G | 0.00161612 | |
MA0677.1-Nr2f6 | 0.00161612 | |
MA0856.1-RXRG | 0.00161612 | |
MA1550.1-PPARD | 0.00161612 |
No TOMTOM matches passing threshold
Motif ID | q-val | PWM |
---|---|---|
MA0833.2-ATF4 | 6.43339e-05 | |
MA1636.1-CEBPG | 8.9149e-05 | |
MA0025.2-NFIL3 | 0.0321598 | |
MA1702.1-Pdp1 | 0.0321598 | |
MA0043.3-HLF | 0.0927352 |
Motif ID | q-val | PWM |
---|---|---|
MA1961.1-PATZ1 | 0.000694171 | |
MA1723.1-PRDM9 | 0.000694171 | |
MA1890.1-Klf15 | 0.000699883 | |
MA1653.1-ZNF148 | 0.000725633 | |
MA1892.1-Klf5-like | 0.000725633 |
Motif ID | q-val | PWM |
---|---|---|
MA1278.1-DOF3.4 | 0.150889 | |
MA1279.1-DOF1.5 | 0.150889 | |
MA1274.1-DOF3.6 | 0.150889 | |
MA1281.1-DOF5.1 | 0.150889 | |
MA1268.1-CDF5 | 0.150889 |
Motif ID | q-val | PWM |
---|---|---|
MA1820.1-Zm00001d024324 | 0.00155765 | |
MA0146.2-Zfx | 0.00155765 | |
MA1817.1-Zm00001d020267 | 0.00228389 | |
MA1819.1-Zm00001d005892 | 0.00326366 | |
MA0026.1-Eip74EF | 0.0033888 |
Motif ID | q-val | PWM |
---|---|---|
MA0379.1-MOT2 | 0.062833 |
Motif ID | q-val | PWM |
---|---|---|
MA0753.2-ZNF740 | 0.0062538 | |
MA1819.1-Zm00001d005892 | 0.0062538 | |
MA1833.1-Zm00001d049364 | 0.0062538 | |
MA1713.1-ZNF610 | 0.0062538 | |
MA0079.5-SP1 | 0.0062538 |
Motif ID | q-val | PWM |
---|---|---|
MA0506.2-Nrf1 | 0.000416793 | |
MA1880.1-Hey | 0.00349234 | |
MA1650.1-ZBTB14 | 0.0182802 | |
MA1833.1-Zm00001d049364 | 0.0204018 | |
MA0146.2-Zfx | 0.0315681 |
Motif ID | q-val | PWM |
---|---|---|
MA0748.2-YY2 | 0.000316945 | |
MA1927.1-YY1-2 | 0.000316945 | |
MA1833.1-Zm00001d049364 | 0.000316945 | |
MA1819.1-Zm00001d005892 | 0.000316945 | |
MA1651.1-ZFP42 | 0.00033601 |
Motif ID | q-val | PWM |
---|---|---|
MA1833.1-Zm00001d049364 | 0.000705261 | |
MA1961.1-PATZ1 | 0.000705261 | |
MA1513.1-KLF15 | 0.000740664 | |
MA1713.1-ZNF610 | 0.00107834 | |
MA1653.1-ZNF148 | 0.00377721 |
Motif ID | q-val | PWM |
---|---|---|
MA0846.1-FOXC2 | 0.00303233 | |
MA0032.2-FOXC1 | 0.00303233 | |
MA1861.1-FoxB | 0.00303233 | |
MA0546.1-pha-4 | 0.00303233 | |
MA1683.1-FOXA3 | 0.00549028 |
No TOMTOM matches passing threshold
No TOMTOM matches passing threshold
Motif ID | q-val | PWM |
---|---|---|
MA1820.1-Zm00001d024324 | 0.000627126 | |
MA1817.1-Zm00001d020267 | 0.000727272 | |
MA1819.1-Zm00001d005892 | 0.000831335 | |
MA1832.1-Zm00001d002364 | 0.00229992 | |
MA1821.1-Zm00001d020595 | 0.00275167 |
Motif ID | q-val | PWM |
---|---|---|
MA1051.1-RAP2-3 | 0.00375025 | |
MA1053.1-ERF109 | 0.00562944 | |
MA1754.1-ERF073 | 0.0056309 | |
MA0997.1-ERF069 | 0.0108585 | |
MA0975.1-CRF2 | 0.0108585 |
Motif ID | q-val | PWM |
---|---|---|
MA1573.2-Thap11 | 8.37313e-06 |
Motif ID | q-val | PWM |
---|---|---|
MA0484.2-HNF4G | 0.124764 | |
MA0809.2-TEAD4 | 0.124764 | |
MA0114.4-HNF4A | 0.124764 | |
MA1111.1-NR2F2 | 0.331627 | |
MA1121.1-TEAD2 | 0.331627 |
Motif ID | q-val | PWM |
---|---|---|
MA1859.1-FoxA-a | 0.0210462 | |
MA0846.1-FOXC2 | 0.0210462 | |
MA0284.2-CIN5 | 0.0210462 | |
MA1867.1-FoxI-b | 0.022439 | |
MA1606.1-Foxf1 | 0.0263175 |
Motif ID | q-val | PWM |
---|---|---|
MA1653.1-ZNF148 | 0.0424802 | |
MA1723.1-PRDM9 | 0.0424802 | |
MA0471.2-E2F6 | 0.0492121 | |
MA1630.2-ZNF281 | 0.0711584 | |
MA1961.1-PATZ1 | 0.0711584 |
Motif ID | q-val | PWM |
---|---|---|
MA1448.1-fos-1 | 0.0825551 | |
MA0580.1-DYT1 | 0.339943 | |
MA0841.1-NFE2 | 0.339943 | |
MA0655.1-JDP2 | 0.339943 | |
MA1633.2-BACH1 | 0.34033 |
No TOMTOM matches passing threshold
Motif ID | q-val | PWM |
---|---|---|
MA0528.2-ZNF263 | 0.0155904 | |
MA1965.1-SP5 | 0.0155904 | |
MA1522.1-MAZ | 0.0155904 | |
MA1284.1-TCP1 | 0.0155904 | |
MA1627.1-Wt1 | 0.0155904 |