# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 2 M0424_1.02 (SNAI3)_(Mus_musculus)_(DBD_0.75) NNTGACAKNN 1.1e0000 1.5e-003 -6.49 0.0 11 59 7 8 0.18644 5.2e-005 29 2 M0901_1.02 AC226150.2 CWTGTCAA 4.5e0000 6.1e-003 -5.10 0.0 11 61 6 7 0.18033 2.0e-004 30 2 M1528_1.02 (RFX6)_(Mus_musculus)_(DBD_0.66) VCNTRGYWAC 4.4e0000 6.0e-003 -5.12 0.0 3 59 4 7 0.05085 2.1e-004 29 2 M5435_1.02 FOXB1 TCGCYGTGTCATTC 2.0e-001 2.6e-004 -8.24 0.0 13 55 8 8 0.23636 9.7e-006 27 2 M5621_1.02 MEIS3 SCTGTCAH 9.3e-001 1.3e-003 -6.68 0.0 11 61 7 8 0.18033 4.2e-005 30 2 M6199_1.02 EGR2 DGVGTGGGCGG 2.0e-002 2.7e-005 -10.52 0.0 2 58 5 7 0.03448 9.7e-007 28 2 M6200_1.02 EGR3 WGAGTGGGYGT 4.2e-001 5.6e-004 -7.49 0.0 2 58 4 6 0.03448 2.0e-005 28 2 M6267_1.02 GLIS3 GYGGGGGGTM 5.3e-001 7.1e-004 -7.26 0.0 5 59 5 6 0.08475 2.4e-005 29 2 M6274_1.02 HIC1 GGGKTGCCC 1.4e-001 1.9e-004 -8.59 0.0 6 60 6 7 0.10000 6.4e-006 29 2 M6333_1.02 MAFG MATGACT 1.5e-001 2.0e-004 -8.50 0.0 14 62 8 8 0.22581 6.8e-006 30 2 M6359_1.02 NFE2L1 NATGACD 1.5e-001 2.0e-004 -8.50 0.0 14 62 8 8 0.22581 6.8e-006 30 2 M6360_1.02 NFE2L2 VRTGACTCAGCA 1.1e0000 1.4e-003 -6.56 0.0 19 57 9 9 0.33333 5.1e-005 28 2 M6542_1.02 ZBTB6 VGRTGATRGAGCC 9.0e0000 1.2e-002 -4.41 0.0 12 56 5 5 0.21429 4.5e-004 27 2 M6550_1.02 ZIC3 BGGGTGGYC 1.4e-001 1.9e-004 -8.59 0.0 6 60 6 7 0.10000 6.4e-006 29 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).