# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 TCCYGCCTCAGCCTCC MEME-1 TCCYGCCTCAGCCTCC 9.0e-178 1.2e-180 -414.29 0.0 65 485 384 594 0.13402 4.9e-183 242 1 GGATCRCTTGAG MEME-2 GGATCRCTTGAG 1.1e-076 1.4e-079 -181.56 0.0 43 489 170 354 0.08793 5.8e-082 244 1 GGAGGTGGAGGCTGCA MEME-3 GGAGGTGGAGGCTGCA 1.0e-097 1.4e-100 -229.93 0.0 71 485 274 477 0.14639 5.7e-103 242 2 GGAGGCY DREME-1 GGAGGCY 1.5e-159 1.9e-162 -372.35 0.0 74 494 371 563 0.14980 7.9e-165 246 2 ATYCTCC DREME-2 ATCCTCC 9.7e-084 1.3e-086 -197.77 0.0 48 494 172 312 0.09717 5.2e-089 246 2 CAGTGAGY DREME-3 CAGTGAGC 6.1e-036 8.1e-039 -87.71 0.0 103 493 126 190 0.20892 3.3e-041 246 2 CTTGARCC DREME-4 CTTGARCC 1.3e-036 1.7e-039 -89.29 0.0 55 493 98 193 0.11156 6.8e-042 246 2 CRRCCTC DREME-5 CARCCTC 1.8e-139 2.4e-142 -326.10 0.0 72 494 337 535 0.14575 9.7e-145 246 2 TARTCCCA DREME-6 TAATCCCA 9.7e-007 1.3e-009 -20.47 0.0 105 493 96 231 0.21298 5.2e-012 246 2 GCTACTY DREME-7 GCTACTC 4.6e-026 6.1e-029 -64.97 0.0 90 494 104 183 0.18219 2.5e-031 246 2 AMCTCCTG DREME-8 AMCTCCTG 1.5e-014 2.0e-017 -38.47 0.0 51 493 66 189 0.10345 8.0e-020 246 2 GAGGY DREME-9 GAGGC 1.6e-086 2.1e-089 -204.17 0.0 70 496 294 600 0.14113 8.7e-092 247 2 AGGCTGGW DREME-10 AGGCTGGW 2.9e-019 3.9e-022 -49.31 0.0 167 493 185 292 0.33874 1.6e-024 246 2 TGCAGTGR DREME-11 TGCAGTGG 6.3e-023 8.4e-026 -57.74 0.0 127 493 145 245 0.25761 3.4e-028 246 2 CAGGCRTG DREME-13 CAGGCATG 6.6e-003 8.7e-006 -11.65 0.0 133 493 83 180 0.26978 3.6e-008 246 2 AAAATWA DREME-14 AAAATWA 4.6e-005 6.0e-008 -16.62 0.0 216 494 167 266 0.43725 2.5e-010 246 2 AGATYGCG DREME-15 AGATCGCG 2.0e-002 2.6e-005 -10.55 0.0 119 493 68 157 0.24138 1.1e-007 246 2 GGGCAACA DREME-16 GGGCAACA 6.1e-004 8.2e-007 -14.02 0.0 233 493 232 371 0.47262 3.3e-009 246 2 CTCTACWA DREME-17 CTCTACWA 5.6e-010 7.4e-013 -27.93 0.0 215 493 216 332 0.43611 3.0e-015 246 3 M0085_1.02 (TFAP2E)_(Mus_musculus)_(DBD_0.99) THGCCYSVGG 8.9e-005 1.2e-007 -15.96 0.0 49 491 108 587 0.09980 4.8e-010 245 3 M0216_1.02 (NHLH2)_(Mus_musculus)_(DBD_1.00) NGCAGCTGYN 2.6e0000 3.4e-003 -5.68 0.0 99 491 159 576 0.20163 1.4e-005 245 3 M0422_1.02 (ZIC5)_(Mus_musculus)_(DBD_0.99) SYRGGGGGTM 2.8e-006 3.8e-009 -19.40 0.0 51 491 117 598 0.10387 1.5e-011 245 3 M0428_1.02 (ZNF691)_(Mus_musculus)_(DBD_0.97) RKGAGYAC 6.7e-004 8.8e-007 -13.94 0.0 15 493 47 594 0.03043 3.6e-009 246 3 M0442_1.02 (ZBTB3)_(Mus_musculus)_(DBD_1.00) NNTGCAGYG 8.8e-015 1.2e-017 -38.99 0.0 138 492 273 597 0.28049 4.8e-020 245 3 M1432_1.02 NR2E1 NYTGACCTCD 9.5e-002 1.3e-004 -8.98 0.0 45 491 87 554 0.09165 5.1e-007 245 3 M1458_1.02 (RORB)_(Tetraodon_nigroviridis)_(DBD_1.00) NNTGACCTCN 4.2e-002 5.6e-005 -9.79 0.0 45 491 89 556 0.09165 2.3e-007 245 3 M1668_1.02 PRKRIR NCCVNVSKRNNN 2.7e-001 3.5e-004 -7.95 0.0 95 489 156 562 0.19427 1.4e-006 244 3 M1838_1.02 TFAP2A NHYDGCCYSAGGGCA 3.5e-015 4.6e-018 -39.91 0.0 42 486 122 575 0.08642 1.9e-020 242 3 M1906_1.02 SP1 GGGGGMGGGGC 6.0e-010 8.0e-013 -27.85 0.0 58 490 139 593 0.11837 3.3e-015 244 3 M1917_1.02 USF1 GGTCACRTGRB 4.1e0000 5.4e-003 -5.22 0.0 26 490 48 471 0.05306 2.2e-005 244 3 M1950_1.02 ZNF354C GTGGAK 1.8e-001 2.4e-004 -8.32 0.0 111 495 182 588 0.22424 9.9e-007 247 3 M1963_1.02 (ZFY)_(Mus_musculus)_(DBD_0.97) SSSGSCBVGGCCTS 1.6e-039 2.2e-042 -95.94 0.0 59 487 204 595 0.12115 8.8e-045 243 3 M1968_1.02 EBF1 TCCCWGGGGRV 1.6e-016 2.1e-019 -43.00 0.0 64 490 162 575 0.13061 8.7e-022 244 3 M2273_1.02 E2F6 RGGCGGGARRV 5.7e-029 7.6e-032 -71.66 0.0 52 490 171 597 0.10612 3.1e-034 244 3 M2314_1.02 SP2 SSSVRGRGGCGGGRC 9.3e-014 1.2e-016 -36.63 0.0 54 486 142 587 0.11111 5.1e-019 242 3 M2387_1.02 SREBF1 RTGGGGTGAB 1.5e0000 2.0e-003 -6.22 0.0 137 491 200 547 0.27902 8.1e-006 245 3 M2388_1.02 SREBF2 RTGGGGTGAY 5.0e0000 6.6e-003 -5.02 0.0 119 491 173 539 0.24236 2.7e-005 245 3 M2390_1.02 EHF SAGGAAGK 2.9e0000 3.8e-003 -5.57 0.0 53 493 93 557 0.10751 1.6e-005 246 3 M4438_1.02 ESRRA RGGTCANKSTGACCY 3.5e0000 4.6e-003 -5.38 0.0 122 486 184 559 0.25103 1.9e-005 242 3 M4451_1.02 ATF3 GGTCACGTGRS 3.6e0000 4.8e-003 -5.34 0.0 22 490 41 443 0.04490 2.0e-005 244 3 M4459_1.02 EGR1 SBGCGKGGGCGGVGGSGSGG 9.9e-008 1.3e-010 -22.75 0.0 65 481 136 542 0.13514 5.5e-013 240 3 M4471_1.02 PAX5 BCAGYSRAGCGTGAC 3.4e-015 4.5e-018 -39.95 0.0 168 486 305 569 0.34568 1.8e-020 242 3 M4476_1.02 RFX5 TCABYWGTTGCYRGG 2.7e-001 3.6e-004 -7.94 0.0 82 486 141 572 0.16872 1.5e-006 242 3 M4481_1.02 USF2 GGTCACGTGRSSSSV 1.1e-003 1.4e-006 -13.47 0.0 26 486 52 403 0.05350 5.9e-009 242 3 M4484_1.02 ZNF143 CTGGGARTTGTAGTY 1.9e-008 2.5e-011 -24.41 0.0 66 486 112 404 0.13580 1.0e-013 242 3 M4525_1.02 TFAP2C NGCCYSAGGSCANDB 9.6e-004 1.3e-006 -13.58 0.0 48 486 99 553 0.09877 5.2e-009 242 3 M4537_1.02 E2F4 SGCGGGAARWTBVRR 5.9e-012 7.8e-015 -32.48 0.0 40 486 112 578 0.08230 3.2e-017 242 3 M4572_1.02 MAFF TGCTGACTCAGCAWW 4.9e-004 6.6e-007 -14.24 0.0 80 486 116 412 0.16461 2.7e-009 242 3 M4604_1.02 ZNF263 RRGGAGGASGVVGRGGRGGRG 2.3e-013 3.0e-016 -35.73 0.0 70 480 170 592 0.14583 1.3e-018 239 3 M4612_1.02 CTCFL CCRSCAGGGGGCGCY 1.5e-003 2.0e-006 -13.11 0.0 40 486 78 477 0.08230 8.4e-009 242 3 M4636_1.02 THAP1 YTGCCCDBANYMAAGATGGCG 3.4e0000 4.5e-003 -5.41 0.0 110 480 89 259 0.22917 1.9e-005 239 3 M4681_1.02 BACH2 TGCTGAGTCA 3.4e-006 4.5e-009 -19.23 0.0 71 491 115 428 0.14460 1.8e-011 245 3 M5425_1.02 ETV6 CCGGAASCGGAAGYR 1.1e-003 1.4e-006 -13.45 0.0 66 486 90 360 0.13580 6.0e-009 242 3 M5632_1.02 MLX RTCACGTGAT 4.8e-003 6.4e-006 -11.96 0.0 27 491 45 325 0.05499 2.6e-008 245 3 M5702_1.02 PAX1 DKCABTCAWGCGTGACG 3.5e-003 4.7e-006 -12.28 0.0 168 484 128 246 0.34711 1.9e-008 241 3 M5711_1.02 PAX9 KKCASTCAWGCGTGACS 1.8e-006 2.4e-009 -19.86 0.0 150 484 118 222 0.30992 9.9e-012 241 3 M5777_1.02 RFX4 NGTWRCCATGGYWACS 4.7e0000 6.3e-003 -5.07 0.0 101 485 110 368 0.20825 2.6e-005 242 3 M5974_1.02 ZNF524 GGGTTCRAGGGT 4.2e-013 5.6e-016 -35.11 0.0 43 489 100 443 0.08793 2.3e-018 244 3 M5977_1.02 ZNF740 GTGGGGGGGK 2.2e0000 3.0e-003 -5.82 0.0 17 491 39 530 0.03462 1.2e-005 245 3 M6115_1.02 TP73 CATGYCWGRRCHTGY 8.9e-017 1.2e-019 -43.59 0.0 56 486 149 566 0.11523 4.9e-022 242 3 M6123_1.02 (ZNF281)_(Mus_musculus)_(DBD_1.00) GRGKTGGGGGAGGGG 1.5e-011 2.0e-014 -31.55 0.0 50 486 125 560 0.10288 8.2e-017 242 3 M6144_1.02 TFAP2B BCCCBCRGGC 3.7e-021 4.9e-024 -53.67 0.0 57 491 164 593 0.11609 2.0e-026 245 3 M6146_1.02 TFAP2D ACGSGCCBCRGGCS 1.1e-034 1.5e-037 -84.81 0.0 55 487 176 535 0.11294 6.0e-040 243 3 M6150_1.02 ARNT2 GYSYSCCACGNC 2.2e-003 3.0e-006 -12.73 0.0 155 489 255 597 0.31697 1.2e-008 244 3 M6155_1.02 ATF6 GBGSTGACGTGG 1.3e-006 1.7e-009 -20.19 0.0 61 489 111 463 0.12474 7.0e-012 244 3 M6161_1.02 BHLHE41 WSVRKSYCACGTGMHGRRRV 1.9e-005 2.6e-008 -17.47 0.0 37 481 86 537 0.07692 1.1e-010 240 3 M6162_1.02 ARNTL GRGTCACGTGTYCM 3.0e-009 4.0e-012 -26.25 0.0 31 487 62 324 0.06366 1.6e-014 243 3 M6184_1.02 CUX1 RBRSNDATCGATSB 8.5e-009 1.1e-011 -25.20 0.0 35 487 86 493 0.07187 4.7e-014 243 3 M6187_1.02 DDIT3 GGGGATTGCABBB 4.6e-002 6.1e-005 -9.70 0.0 88 488 149 559 0.18033 2.5e-007 243 3 M6199_1.02 EGR2 DGVGTGGGCGG 1.7e0000 2.3e-003 -6.07 0.0 20 490 46 571 0.04082 9.5e-006 244 3 M6221_1.02 ETS2 VMVGGAAGTKS 3.4e-009 4.5e-012 -26.12 0.0 54 490 131 600 0.11020 1.9e-014 244 3 M6302_1.02 HOXD13 TCYCTAATAAA 3.7e-002 4.9e-005 -9.93 0.0 204 490 290 553 0.41633 2.0e-007 244 3 M6321_1.02 KLF15 RSMKGGGAGDKGGGGSS 2.9e-015 3.9e-018 -40.09 0.0 50 484 138 584 0.10331 1.6e-020 241 3 M6322_1.02 KLF1 CAGGGTGKGGC 6.5e-004 8.6e-007 -13.96 0.0 142 490 238 592 0.28980 3.5e-009 244 3 M6325_1.02 KLF6 GGGGGCKG 1.1e-001 1.4e-004 -8.88 0.0 63 493 118 593 0.12779 5.7e-007 246 3 M6330_1.02 MAFA STGCTGACBMYGCARYHTYCV 2.6e-020 3.5e-023 -51.70 0.0 56 480 163 593 0.11667 1.5e-025 239 3 M6336_1.02 MAZ RGGGDRGGGAGGGRGGG 8.1e-022 1.1e-024 -55.19 0.0 86 484 216 594 0.17769 4.5e-027 241 3 M6337_1.02 MBD2 SSGKCCGGMGR 5.6e-016 7.4e-019 -41.75 0.0 48 490 124 512 0.09796 3.0e-021 244 3 M6339_1.02 MECP2 YYCCGGS 1.9e-012 2.5e-015 -33.63 0.0 50 494 126 561 0.10121 1.0e-017 246 3 M6374_1.02 NKX2-1 STCAAGKGCH 3.4e-002 4.6e-005 -9.99 0.0 27 491 65 597 0.05499 1.9e-007 245 3 M6376_1.02 NKX2-5 TYAAGTG 1.5e-005 2.0e-008 -17.74 0.0 26 494 70 575 0.05263 8.0e-011 246 3 M6377_1.02 NKX2-8 TTCAAGKRC 1.5e-002 2.0e-005 -10.80 0.0 24 492 59 569 0.04878 8.3e-008 245 3 M6385_1.02 NR1I2 VTGAMCTYNNTTRACCYHH 8.3e0000 1.1e-002 -4.51 0.0 30 482 57 532 0.06224 4.6e-005 240 3 M6420_1.02 PLAG1 GGRGGSMHNWVKAGGGG 1.2e-009 1.6e-012 -27.17 0.0 64 484 148 589 0.13223 6.6e-015 241 3 M6422_1.02 PLAGL1 CRGGGGGCCC 2.1e-021 2.8e-024 -54.22 0.0 79 491 193 556 0.16090 1.2e-026 245 3 M6442_1.02 PURA CCMBGCCCNCCMMYWCC 2.4e-027 3.2e-030 -67.91 0.0 66 484 196 599 0.13636 1.3e-032 241 3 M6445_1.02 RARB BBBBTGACCTS 2.1e-003 2.8e-006 -12.80 0.0 32 490 76 587 0.06531 1.1e-008 244 3 M6469_1.02 SNAI2 BCAGGTG 9.8e-001 1.3e-003 -6.65 0.0 28 494 62 595 0.05668 5.3e-006 246 3 M6482_1.02 SP3 VGVVGGGGGCGGGGCBRGSS 9.2e-010 1.2e-012 -27.43 0.0 79 481 172 586 0.16424 5.1e-015 240 3 M6483_1.02 SP4 GSGGCCRGGGGSGGGGSGGSSSSR 4.5e0000 6.0e-003 -5.12 0.0 45 477 71 458 0.09434 2.5e-005 238 3 M6505_1.02 TBX5 AGGTGTGA 6.5e0000 8.6e-003 -4.76 0.0 19 493 44 593 0.03854 3.5e-005 246 3 M6514_1.02 TFCP2 SCCWGMNMDSRCCRGA 3.0e-001 3.9e-004 -7.84 0.0 65 485 121 592 0.13402 1.6e-006 242 3 M6518_1.02 TFEB RGTCACGTG 2.5e-001 3.3e-004 -8.00 0.0 24 492 38 333 0.04878 1.4e-006 245 3 M6519_1.02 TGIF1 MWGSTGACACCTSMCA 3.6e0000 4.8e-003 -5.35 0.0 125 485 195 583 0.25773 2.0e-005 242 3 M6527_1.02 TWIST1 MCCCAGGTGK 4.5e0000 6.0e-003 -5.12 0.0 219 491 285 533 0.44603 2.4e-005 245 3 M6535_1.02 WT1 GMGGGGGCGKGGG 1.6e-002 2.1e-005 -10.77 0.0 56 488 109 571 0.11475 8.6e-008 243 3 M6542_1.02 ZBTB6 VGRTGATRGAGCC 1.3e-001 1.7e-004 -8.70 0.0 170 488 247 549 0.34836 6.9e-007 243 3 M6547_1.02 ZFX SVGSSSSSCAGGCCBVGSC 1.3e-014 1.7e-017 -38.59 0.0 70 482 172 589 0.14523 7.2e-020 240 3 M6548_1.02 ZIC1 KGGGWGGTV 4.0e-002 5.3e-005 -9.84 0.0 34 492 77 599 0.06911 2.2e-007 245 3 M6550_1.02 ZIC3 BGGGTGGYC 1.3e-016 1.7e-019 -43.19 0.0 68 492 173 596 0.13821 7.1e-022 245 3 M6552_1.02 ZNF148 KGVGKGGGGGAGGGG 2.7e-002 3.6e-005 -10.22 0.0 52 486 102 568 0.10700 1.5e-007 242 3 M6553_1.02 ZNF219 GDGGGGGGYGGA 2.5e-005 3.3e-008 -17.22 0.0 75 489 149 586 0.15337 1.4e-010 244 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).