# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 AGGTCACACAGC MEME-1 AGGTCACACAGC 5.5e-234 7.3e-237 -543.72 0.0 85 489 446 541 0.17382 3.0e-239 244 1 CTTAACCTCTCTGDGC MEME-2 CTTAACCTCTCTGDGC 1.0e-270 1.4e-273 -628.27 0.0 63 485 436 546 0.12990 5.8e-276 242 1 CCATTTTACAGATGAGGAAA MEME-3 CCATTTTACAGATGAGGAAA 5.3e-054 7.0e-057 -129.30 0.0 111 481 269 461 0.23077 2.9e-059 240 1 TGGGCAAGT MEME-4 TGGGCAAGT 2.9e-077 3.9e-080 -182.85 0.0 34 492 188 523 0.06911 1.6e-082 245 1 RAATCCYRGCTCTGCCACTT MEME-5 RAATCCYRGCTCTGCCACTT 4.6e-034 6.1e-037 -83.38 0.0 125 481 246 444 0.25988 2.5e-039 240 1 CTYAGTTTCCTCAYCT MEME-7 CTYAGTTTCCTCAYCT 6.3e-028 8.4e-031 -69.25 0.0 95 485 190 417 0.19588 3.5e-033 242 1 AYCYAYCTCATRGRRTTGTTGKGAGGATTAA MEME-8 AYCYAYCTCATRGRRTTGTTGKGAGGATTAA 3.2e-016 4.3e-019 -42.30 0.0 200 470 95 110 0.42553 1.8e-021 234 1 TGTCTCTGTKCY MEME-9 TGTCTCTGTKCY 1.8e-028 2.4e-031 -70.52 0.0 77 489 135 296 0.15746 9.7e-034 244 2 CAGAGAVG DREME-1 CAGAGAGG 4.2e-224 5.5e-227 -520.97 0.0 67 493 376 474 0.13590 2.3e-229 246 2 CACACAGY DREME-2 CACACAGC 4.5e-193 5.9e-196 -449.52 0.0 89 493 369 439 0.18053 2.4e-198 246 2 ACCTTRG DREME-3 ACCTTGG 5.3e-052 7.0e-055 -124.69 0.0 50 494 107 185 0.10121 2.9e-057 246 2 AAGTHACT DREME-4 AAGTMACT 3.6e-049 4.8e-052 -118.16 0.0 61 493 89 119 0.12373 2.0e-054 246 2 AAAMTGR DREME-5 AAAMTGR 7.5e-008 1.0e-010 -23.02 0.0 96 494 111 296 0.19433 4.1e-013 246 2 ACAGATGM DREME-6 ACAGATGA 3.6e-008 4.9e-011 -23.75 0.0 119 493 123 279 0.24138 2.0e-013 246 2 GCTYTGCC DREME-7 GCTCTGCC 6.1e-002 8.1e-005 -9.42 0.0 167 493 64 112 0.33874 3.3e-007 246 2 GCCTCR DREME-8 GCCTCA 4.1e-002 5.4e-005 -9.83 0.0 81 495 92 333 0.16364 2.2e-007 247 2 GGGCAAGK DREME-9 GGGCAAGK 1.1e-036 1.5e-039 -89.38 0.0 45 493 79 148 0.09128 6.2e-042 246 3 M0085_1.02 (TFAP2E)_(Mus_musculus)_(DBD_0.99) THGCCYSVGG 1.4e-022 1.9e-025 -56.95 0.0 45 491 143 579 0.09165 7.6e-028 245 3 M0199_1.02 (HES2)_(Mus_musculus)_(DBD_0.83) NNNNGRCACGTGM 6.2e-004 8.2e-007 -14.01 0.0 22 488 60 572 0.04508 3.4e-009 243 3 M0216_1.02 (NHLH2)_(Mus_musculus)_(DBD_1.00) NGCAGCTGYN 1.4e-002 1.9e-005 -10.87 0.0 143 491 228 578 0.29124 7.8e-008 245 3 M0300_1.02 (ATF2)_(Mus_musculus)_(DBD_1.00) NRTKACGTMA 3.1e-006 4.2e-009 -19.30 0.0 59 491 122 547 0.12016 1.7e-011 245 3 M1030_1.02 (NKX2-3)_(Mus_musculus)_(DBD_1.00) NVYACTTVD 2.1e-002 2.8e-005 -10.47 0.0 90 492 157 580 0.18293 1.2e-007 245 3 M1281_1.02 (NAIF1)_(Xenopus_tropicalis)_(DBD_0.71) NNTACGYHN 5.7e-004 7.6e-007 -14.09 0.0 66 492 80 305 0.13415 3.1e-009 245 3 M1432_1.02 NR2E1 NYTGACCTCD 1.3e-071 1.7e-074 -169.86 0.0 55 491 237 569 0.11202 6.9e-077 245 3 M1458_1.02 (RORB)_(Tetraodon_nigroviridis)_(DBD_1.00) NNTGACCTCN 2.3e-072 3.0e-075 -171.58 0.0 55 491 240 577 0.11202 1.2e-077 245 3 M1628_1.02 (TBX10)_(Mus_musculus)_(DBD_0.87) AGGTGTGAANN 4.9e-036 6.5e-039 -87.92 0.0 56 490 185 564 0.11429 2.7e-041 244 3 M1838_1.02 TFAP2A NHYDGCCYSAGGGCA 1.9e-018 2.5e-021 -47.44 0.0 28 486 101 569 0.05761 1.0e-023 242 3 M1841_1.02 AR GNACABNVTGTTCYY 1.6e-011 2.1e-014 -31.50 0.0 70 486 159 574 0.14403 8.6e-017 242 3 M1925_1.02 CEBPA DRTTRTGCAAT 5.7e-008 7.6e-011 -23.30 0.0 72 490 137 504 0.14694 3.1e-013 244 3 M1934_1.02 ESR1 RGGTCAGGGTGACCTKGVNB 2.8e-010 3.8e-013 -28.60 0.0 93 481 189 563 0.19335 1.6e-015 240 3 M2065_1.02 ESR2 RGGKCANBSTGACCT 2.6e-045 3.4e-048 -109.29 0.0 88 486 259 572 0.18107 1.4e-050 242 3 M2268_1.02 CEBPB KATTGCAYMAY 4.8e0000 6.4e-003 -5.05 0.0 70 490 104 490 0.14286 2.6e-005 244 3 M2278_1.02 FOS DVTGASTCATB 1.3e0000 1.7e-003 -6.38 0.0 94 490 129 466 0.19184 7.0e-006 244 3 M2289_1.02 JUN DDRATGATGTMAT 6.0e0000 8.0e-003 -4.83 0.0 204 488 237 464 0.41803 3.3e-005 243 3 M2292_1.02 JUND DRTGASTCATS 4.7e0000 6.2e-003 -5.09 0.0 84 490 112 452 0.17143 2.5e-005 244 3 M4438_1.02 ESRRA RGGTCANKSTGACCY 5.7e-015 7.5e-018 -39.43 0.0 98 486 211 574 0.20165 3.1e-020 242 3 M4451_1.02 ATF3 GGTCACGTGRS 1.1e-001 1.4e-004 -8.86 0.0 26 490 52 462 0.05306 5.8e-007 244 3 M4511_1.02 RXRA TGACCYYW 3.7e-068 4.9e-071 -161.89 0.0 67 493 261 588 0.13590 2.0e-073 246 3 M4525_1.02 TFAP2C NGCCYSAGGSCANDB 4.1e-007 5.4e-010 -21.33 0.0 26 486 74 567 0.05350 2.2e-012 242 3 M4526_1.02 SMARCC1 DSRVDGTGASTCABV 7.7e-002 1.0e-004 -9.19 0.0 80 486 126 500 0.16461 4.2e-007 242 3 M4551_1.02 ZNF274 YTCAYACTGGAGAGAAA 2.5e-004 3.3e-007 -14.93 0.0 78 484 84 274 0.16116 1.4e-009 241 3 M4565_1.02 FOSL2 VDGGATGASTCAYH 4.3e-003 5.7e-006 -12.07 0.0 81 487 122 453 0.16632 2.4e-008 243 3 M4569_1.02 HSF1 GTCSYGGGTTCGADTCCC 1.5e-004 2.0e-007 -15.41 0.0 141 483 133 288 0.29193 8.4e-010 241 3 M4572_1.02 MAFF TGCTGACTCAGCAWW 2.5e0000 3.3e-003 -5.72 0.0 20 486 38 440 0.04115 1.4e-005 242 3 M4619_1.02 FOSL1 BGGTGASTCAK 1.3e-001 1.8e-004 -8.64 0.0 92 490 124 435 0.18776 7.2e-007 244 3 M4629_1.02 NFE2 VRTGACTCAGCANWWYB 1.1e-043 1.4e-046 -105.56 0.0 94 484 237 481 0.19421 6.0e-049 241 3 M4681_1.02 BACH2 TGCTGAGTCA 2.7e-016 3.7e-019 -42.45 0.0 89 491 180 497 0.18126 1.5e-021 245 3 M4702_1.02 NR2F2 TGACCTTT 1.1e-071 1.5e-074 -169.97 0.0 67 493 268 598 0.13590 6.2e-077 246 3 M5234_1.02 (SIM1)_(Drosophila_melanogaster)_(DBD_0.89) GGTCACGTAC 3.1e-001 4.2e-004 -7.78 0.0 23 491 40 370 0.04684 1.7e-006 245 3 M5293_1.02 ATF7 NKATGACGTCATHN 4.3e-001 5.7e-004 -7.47 0.0 119 487 86 222 0.24435 2.3e-006 243 3 M5323_1.02 CREB3 KGRTGACGTCAYNV 1.5e-001 2.0e-004 -8.51 0.0 119 487 92 238 0.24435 8.3e-007 243 3 M5435_1.02 FOXB1 TCGCYGTGTCATTC 4.4e-028 5.9e-031 -69.61 0.0 77 487 187 488 0.15811 2.4e-033 243 3 M5493_1.02 GMEB2 KTRCGTAA 8.6e-002 1.1e-004 -9.08 0.0 25 493 46 412 0.05071 4.6e-007 246 3 M5517_1.02 HMBOX1 MYTAGTTAMS 4.6e-005 6.1e-008 -16.61 0.0 103 491 169 513 0.20978 2.5e-010 245 3 M5520_1.02 HMX3 BNTTAAKTGNY 1.3e0000 1.7e-003 -6.39 0.0 40 490 76 552 0.08163 6.9e-006 244 3 M5664_1.02 NFIX TTGGCANNNNGCCAR 2.2e0000 2.9e-003 -5.85 0.0 424 486 437 468 0.87243 1.2e-005 242 3 M5889_1.02 TBX21 GGTGTGAHWTCACACC 2.5e-009 3.4e-012 -26.42 0.0 29 485 57 302 0.05979 1.4e-014 242 3 M5998_1.02 (CREB5)_(Mus_musculus)_(DBD_1.00) DRTGACGTCATN 3.5e-015 4.7e-018 -39.91 0.0 81 489 119 308 0.16564 1.9e-020 244 3 M6115_1.02 TP73 CATGYCWGRRCHTGY 4.9e-007 6.5e-010 -21.16 0.0 62 486 134 573 0.12757 2.7e-012 242 3 M6152_1.02 ATF1 VTGACGTCAV 2.1e-006 2.8e-009 -19.69 0.0 41 491 86 477 0.08350 1.1e-011 245 3 M6162_1.02 ARNTL GRGTCACGTGTYCM 7.4e-002 9.9e-005 -9.22 0.0 21 487 37 343 0.04312 4.1e-007 243 3 M6171_1.02 CEBPD RRTKDBGCAAT 2.6e-014 3.4e-017 -37.91 0.0 56 490 142 566 0.11429 1.4e-019 244 3 M6172_1.02 CEBPE VAKATTDCGHAA 6.5e-006 8.6e-009 -18.57 0.0 43 489 96 540 0.08793 3.5e-011 244 3 M6173_1.02 CEBPG VAGATTGCAHAAT 6.8e-007 9.0e-010 -20.83 0.0 58 488 120 530 0.11885 3.7e-012 243 3 M6176_1.02 NR2F1 TGACCTTTGVMC 2.2e-040 2.9e-043 -97.96 0.0 41 489 167 584 0.08384 1.2e-045 244 3 M6180_1.02 CREB1 RTGACGTMA 3.5e-003 4.7e-006 -12.27 0.0 86 492 149 553 0.17480 1.9e-008 245 3 M6181_1.02 CREM CRVTGACGTCA 2.1e-002 2.8e-005 -10.49 0.0 70 490 116 505 0.14286 1.1e-007 244 3 M6186_1.02 DBP BVTTRCATAAB 1.4e-016 1.9e-019 -43.11 0.0 38 490 111 530 0.07755 7.8e-022 244 3 M6197_1.02 E4F1 YGTKACGTC 1.8e-050 2.5e-053 -121.14 0.0 52 492 189 510 0.10569 1.0e-055 245 3 M6205_1.02 ELF3 GGSAAACAGGAARY 1.8e0000 2.4e-003 -6.04 0.0 101 487 157 550 0.20739 9.8e-006 243 3 M6215_1.02 ESRRB TGACCTTGR 2.9e-084 3.9e-087 -198.97 0.0 48 492 239 573 0.09756 1.6e-089 245 3 M6216_1.02 ESRRG TGACCTTGA 2.1e-054 2.8e-057 -130.21 0.0 68 492 232 550 0.13821 1.1e-059 245 3 M6223_1.02 ETV5 GHCAGGAAGWWAY 5.9e-001 7.8e-004 -7.15 0.0 296 488 410 589 0.60656 3.2e-006 243 3 M6264_1.02 GLI1 BTGGGTGGTCY 3.2e-003 4.3e-006 -12.36 0.0 44 490 93 573 0.08980 1.8e-008 244 3 M6277_1.02 HLF SKRTTACRYAAYC 8.3e-009 1.1e-011 -25.23 0.0 74 488 129 441 0.15164 4.6e-014 243 3 M6333_1.02 MAFG MATGACT 1.2e-003 1.6e-006 -13.35 0.0 26 494 66 582 0.05263 6.4e-009 246 3 M6349_1.02 MYBL2 WYAACCKSYA 1.1e-023 1.5e-026 -59.47 0.0 41 491 138 587 0.08350 6.1e-029 245 3 M6359_1.02 NFE2L1 NATGACD 2.1e-001 2.8e-004 -8.18 0.0 90 494 153 583 0.18219 1.1e-006 246 3 M6360_1.02 NFE2L2 VRTGACTCAGCA 2.7e-082 3.6e-085 -194.45 0.0 77 489 301 590 0.15746 1.5e-087 244 3 M6368_1.02 NFIL3 VKVMRTTACRTAAY 1.7e-015 2.2e-018 -40.65 0.0 43 487 95 379 0.08830 9.1e-021 243 3 M6374_1.02 NKX2-1 STCAAGKGCH 3.5e-002 4.6e-005 -9.98 0.0 25 491 61 592 0.05092 1.9e-007 245 3 M6375_1.02 NKX2-2 HAAVYACTTRAM 1.3e-001 1.7e-004 -8.68 0.0 27 489 56 503 0.05521 7.0e-007 244 3 M6376_1.02 NKX2-5 TYAAGTG 6.8e-010 9.1e-013 -27.73 0.0 26 494 81 580 0.05263 3.7e-015 246 3 M6379_1.02 NKX3-2 ARYTAAGTGGV 1.4e0000 1.8e-003 -6.31 0.0 88 490 146 578 0.17959 7.5e-006 244 3 M6384_1.02 NR1H4 AGGTCANTGACCYY 1.9e-042 2.5e-045 -102.70 0.0 49 487 178 539 0.10062 1.0e-047 243 3 M6385_1.02 NR1I2 VTGAMCTYNNTTRACCYHH 1.6e-062 2.1e-065 -148.91 0.0 62 482 242 574 0.12863 8.9e-068 240 3 M6387_1.02 NR1I3 HTGAACTYBBYTGACCYY 1.7e-055 2.3e-058 -132.73 0.0 61 483 228 568 0.12629 9.4e-061 241 3 M6389_1.02 NR2C1 VTGACCTCYBRSC 2.9e-019 3.9e-022 -49.30 0.0 38 488 123 574 0.07787 1.6e-024 243 3 M6391_1.02 NR2E3 TGACTTTTGACTTT 3.6e-002 4.8e-005 -9.94 0.0 23 487 56 563 0.04723 2.0e-007 243 3 M6393_1.02 NR4A1 BTGACCTTB 9.2e-068 1.2e-070 -160.98 0.0 54 492 230 570 0.10976 5.0e-073 245 3 M6394_1.02 NR4A2 STGACCTTT 1.2e-066 1.6e-069 -158.42 0.0 44 492 212 591 0.08943 6.5e-072 245 3 M6395_1.02 NR4A3 STGACCTTTG 5.6e-074 7.5e-077 -175.29 0.0 53 491 226 526 0.10794 3.1e-079 245 3 M6396_1.02 NR5A2 TRRCCTTGRV 2.7e-053 3.5e-056 -127.68 0.0 49 491 202 581 0.09980 1.4e-058 245 3 M6397_1.02 NR6A1 TGAMCTTGAMCTT 5.6e-010 7.5e-013 -27.92 0.0 76 488 137 450 0.15574 3.1e-015 243 3 M6410_1.02 PAX6 TSAWGCGTRAA 1.5e-001 2.0e-004 -8.51 0.0 198 490 286 566 0.40408 8.3e-007 244 3 M6430_1.02 PPARA TGACCTY 1.7e-068 2.3e-071 -162.67 0.0 80 494 286 592 0.16194 9.2e-074 246 3 M6432_1.02 PPARD TGACCTTTVNCCTR 7.2e-001 9.6e-004 -6.95 0.0 29 487 63 573 0.05955 3.9e-006 243 3 M6436_1.02 PGR DACAGRNTGTTCY 7.6e-007 1.0e-009 -20.72 0.0 44 488 106 581 0.09016 4.1e-012 243 3 M6439_1.02 PRRX1 TAAYCTG 1.1e-010 1.5e-013 -29.54 0.0 56 494 130 550 0.11336 6.0e-016 246 3 M6443_1.02 RARA TGACCTB 8.1e-065 1.1e-067 -154.19 0.0 78 494 276 589 0.15789 4.4e-070 246 3 M6445_1.02 RARB BBBBTGACCTS 8.8e-050 1.2e-052 -119.58 0.0 80 490 258 591 0.16327 4.8e-055 244 3 M6446_1.02 RARG BTGACCTBYNGBYGAMCYCC 7.0e-006 9.3e-009 -18.50 0.0 57 481 124 574 0.11850 3.9e-011 240 3 M6454_1.02 RORA TGACCTAVWTWW 2.6e-004 3.4e-007 -14.89 0.0 153 489 203 454 0.31288 1.4e-009 244 3 M6455_1.02 RORC CTGACCYACWTWH 4.6e0000 6.1e-003 -5.10 0.0 116 488 143 440 0.23770 2.5e-005 243 3 M6461_1.02 RXRB YSTGACCTSA 6.0e-043 8.0e-046 -103.84 0.0 79 491 245 593 0.16090 3.3e-048 245 3 M6462_1.02 RXRG DTGACCTTTGACC 1.0e-028 1.4e-031 -71.06 0.0 46 488 133 442 0.09426 5.6e-034 243 3 M6463_1.02 SMAD1 RSCCTGTCTGCC 9.4e-004 1.2e-006 -13.59 0.0 59 489 121 591 0.12065 5.1e-009 244 3 M6465_1.02 SMAD3 STGTCTGBCY 8.3e-001 1.1e-003 -6.81 0.0 77 491 135 594 0.15682 4.5e-006 245 3 M6466_1.02 SMAD4 TGTCTGBCY 5.6e-003 7.4e-006 -11.82 0.0 88 492 159 591 0.17886 3.0e-008 245 3 M6498_1.02 NR5A1 TGRCCTTGR 1.5e-056 2.0e-059 -135.16 0.0 48 492 205 584 0.09756 8.1e-062 245 3 M6510_1.02 TEF TGTTTATRTAAMTK 8.9e-004 1.2e-006 -13.65 0.0 57 487 107 521 0.11704 4.9e-009 243 3 M6518_1.02 TFEB RGTCACGTG 4.4e0000 5.8e-003 -5.15 0.0 22 492 32 318 0.04472 2.4e-005 245 3 M6521_1.02 THRA STGACCTSAV 5.7e-041 7.6e-044 -99.29 0.0 83 491 247 588 0.16904 3.1e-046 245 3 M6523_1.02 THRB TGACCTSABSTSRSSYC 1.0e-004 1.3e-007 -15.84 0.0 40 484 92 565 0.08264 5.5e-010 241 3 M6529_1.02 UBP1 TYTCTGS 1.1e-016 1.4e-019 -43.38 0.0 66 494 170 599 0.13360 5.9e-022 246 3 M6532_1.02 VDR TGAMCYC 6.5e-030 8.7e-033 -73.83 0.0 70 494 205 596 0.14170 3.5e-035 246 3 M6542_1.02 ZBTB6 VGRTGATRGAGCC 8.8e-002 1.2e-004 -9.06 0.0 172 488 243 533 0.35246 4.8e-007 243 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).