# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 YCCCCCYYTSSTKCTC MEME-1 YCCCCCYYTSSTKCTC 6.3e-044 8.6e-047 -106.07 0.0 77 485 235 559 0.15876 3.5e-049 242 1 ACACACACACACACACACACACACACACACA MEME-2 ACACACACACACACACACACACACACACACA 1.8e-003 2.4e-006 -12.95 0.0 128 470 49 87 0.27234 1.0e-008 234 1 TCTYYCTYYCTYYYYY MEME-3 TCTYYCTYYCTYYYYY 8.7e-004 1.2e-006 -13.66 0.0 75 485 134 532 0.15464 4.8e-009 242 2 GGGGAATK DREME-1 GGGGAATK 2.5e-026 3.3e-029 -65.57 0.0 95 493 73 99 0.19270 1.4e-031 246 2 GAGMAC DREME-2 GAGMAC 4.1e-010 5.5e-013 -28.22 0.0 125 495 139 301 0.25253 2.2e-015 247 2 ARGGGGGA DREME-3 ARGGGGGA 1.7e-027 2.3e-030 -68.24 0.0 85 493 94 156 0.17241 9.4e-033 246 3 M0404_1.02 (ZNF202)_(Mus_musculus)_(DBD_0.87) NNNKGGGGSV 5.4e-028 7.4e-031 -69.39 0.0 85 491 224 586 0.17312 3.0e-033 245 3 M0428_1.02 (ZNF691)_(Mus_musculus)_(DBD_0.97) RKGAGYAC 1.9e-002 2.5e-005 -10.59 0.0 125 493 202 575 0.25355 1.0e-007 246 3 M2273_1.02 E2F6 RGGCGGGARRV 2.5e-003 3.4e-006 -12.59 0.0 88 490 153 554 0.17959 1.4e-008 244 3 M4537_1.02 E2F4 SGCGGGAARWTBVRR 1.2e-003 1.6e-006 -13.36 0.0 78 486 134 514 0.16049 6.5e-009 242 3 M4604_1.02 ZNF263 RRGGAGGASGVVGRGGRGGRG 2.6e-012 3.5e-015 -33.30 0.0 114 480 224 560 0.23750 1.4e-017 239 3 M5491_1.02 GLIS2 CDYYGCGGGGGGTC 4.3e-001 5.8e-004 -7.44 0.0 39 487 59 392 0.08008 2.4e-006 243 3 M5965_1.02 ZIC4 DCDCMGCRGGGGGYC 6.1e-004 8.3e-007 -14.00 0.0 66 486 116 499 0.13580 3.4e-009 242 3 M5977_1.02 ZNF740 GTGGGGGGGK 3.3e-006 4.5e-009 -19.22 0.0 77 491 148 552 0.15682 1.8e-011 245 3 M6191_1.02 E2F2 GGCGCGAAAC 1.1e-008 1.4e-011 -24.96 0.0 93 491 151 445 0.18941 5.9e-014 245 3 M6196_1.02 E2F7 WWDGGCGCGAAAM 3.7e0000 5.1e-003 -5.28 0.0 74 488 69 280 0.15164 2.1e-005 243 3 M6199_1.02 EGR2 DGVGTGGGCGG 3.0e-002 4.0e-005 -10.13 0.0 360 490 442 533 0.73469 1.6e-007 244 3 M6200_1.02 EGR3 WGAGTGGGYGT 5.1e-004 6.9e-007 -14.18 0.0 160 490 241 538 0.32653 2.8e-009 244 3 M6212_1.02 EPAS1 CMCACGYAYDCAC 2.6e-002 3.5e-005 -10.27 0.0 122 488 184 522 0.25000 1.4e-007 243 3 M6267_1.02 GLIS3 GYGGGGGGTM 2.0e-001 2.7e-004 -8.24 0.0 83 491 140 561 0.16904 1.1e-006 245 3 M6306_1.02 INSM1 TGTMAGGGGGCR 6.4e-001 8.7e-004 -7.04 0.0 87 489 123 469 0.17791 3.6e-006 244 3 M6336_1.02 MAZ RGGGDRGGGAGGGRGGG 5.6e0000 7.6e-003 -4.88 0.0 84 484 136 563 0.17355 3.2e-005 241 3 M6356_1.02 MZF1 RGDGGGGAD 8.4e-030 1.1e-032 -73.56 0.0 86 492 229 587 0.17480 4.6e-035 245 3 M6381_1.02 NR0B1 YSTCCCMCKC 8.5e0000 1.1e-002 -4.47 0.0 375 491 470 565 0.76375 4.7e-005 245 3 M6420_1.02 PLAG1 GGRGGSMHNWVKAGGGG 2.0e-012 2.8e-015 -33.53 0.0 82 484 178 561 0.16942 1.1e-017 241 3 M6442_1.02 PURA CCMBGCCCNCCMMYWCC 3.6e-001 4.9e-004 -7.62 0.0 148 484 233 587 0.30579 2.0e-006 241 3 M6456_1.02 RREB1 DKGKKKGKGGKTGKTTKGGGKT 5.8e-001 7.8e-004 -7.15 0.0 101 479 143 476 0.21086 3.3e-006 239 3 M6476_1.02 SOX4 GAGAACAAAGSG 2.5e0000 3.4e-003 -5.67 0.0 79 489 124 531 0.16155 1.4e-005 244 3 M6515_1.02 TFDP1 AWWKRGCGGGAAAY 5.0e0000 6.8e-003 -4.99 0.0 89 487 114 433 0.18275 2.8e-005 243 3 M6535_1.02 WT1 GMGGGGGCGKGGG 9.3e0000 1.3e-002 -4.37 0.0 88 488 131 526 0.18033 5.2e-005 243 3 M6552_1.02 ZNF148 KGVGKGGGGGAGGGG 9.9e0000 1.3e-002 -4.32 0.0 80 486 125 542 0.16461 5.5e-005 242 3 M6553_1.02 ZNF219 GDGGGGGGYGGA 8.6e-003 1.2e-005 -11.36 0.0 83 489 143 549 0.16973 4.8e-008 244 3 M6558_1.02 ZNF423 GCACCCTWGGGTGYC 3.3e-003 4.5e-006 -12.32 0.0 50 486 34 119 0.10288 1.8e-008 242 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).