# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 YTGGCMMKSTGCCAAG MEME-1 YTGGCMMKSTGCCAAG 8.6e-037 1.1e-039 -89.66 0.0 55 485 106 221 0.11340 4.7e-042 242 1 HTBWTAAATAGTYY MEME-2 HTBWTAAATAGTYY 5.9e-013 7.9e-016 -34.78 0.0 77 487 107 291 0.15811 3.2e-018 243 1 KGGYAATCADTT MEME-3 KGGYAATCADTT 1.7e-021 2.3e-024 -54.43 0.0 79 489 94 187 0.16155 9.4e-027 244 1 GCGCCCYCTNSYGGCS MEME-4 GCGCCCYCTNSYGGCS 1.9e-006 2.5e-009 -19.81 0.0 153 485 178 367 0.31546 1.0e-011 242 1 CYBTGSCWSVRSYGGGATTCGAACCMRSGACCYCHKG MEME-5 CYBTGSCWSVRSYGGGATTCGAACCMRSGACCYCHKG 8.0e-004 1.1e-006 -13.75 0.0 52 464 12 16 0.11207 4.6e-009 231 1 RRTGACTCA MEME-6 RRTGACTCA 1.0e-008 1.4e-011 -25.00 0.0 158 492 105 176 0.32114 5.7e-014 245 1 CCGSNSCSYKBCBSCBSCGSSG MEME-7 CCGSNSCSYKBCBSCBSCGSSG 3.1e0000 4.2e-003 -5.48 0.0 91 479 97 342 0.18998 1.7e-005 239 1 CCGGAAGTG MEME-9 CCGGAAGTG 2.4e-007 3.2e-010 -21.86 0.0 172 492 120 201 0.34959 1.3e-012 245 1 CAGCRCCMCCTRCTGG MEME-10 CAGCRCCMCCTRCTGG 4.2e-005 5.7e-008 -16.69 0.0 143 485 78 142 0.29485 2.3e-010 242 2 DTAAATA DREME-1 WTAAATA 4.3e-011 5.8e-014 -30.48 0.0 78 494 79 196 0.15789 2.4e-016 246 2 TGACTCAB DREME-2 TGACTCAB 6.0e-009 8.0e-012 -25.55 0.0 201 493 79 101 0.40771 3.3e-014 246 2 GGTMATCA DREME-4 GGTMATCA 1.9e-001 2.5e-004 -8.28 0.0 89 493 43 115 0.18053 1.0e-006 246 2 CYTGGCA DREME-7 CYTGGCA 3.9e-005 5.2e-008 -16.78 0.0 64 494 53 164 0.12955 2.1e-010 246 3 M0432_1.02 (ZFP161)_(Mus_musculus)_(DBD_1.00) NNCGYGCHH 8.9e0000 1.2e-002 -4.44 0.0 320 492 280 376 0.65041 4.9e-005 245 3 M0609_1.02 DNMT1 NNCCGMNNNN 4.5e0000 5.9e-003 -5.13 0.0 249 491 280 466 0.50713 2.4e-005 245 3 M0610_1.02 TET1 NNYRCGYWN 7.8e0000 1.0e-002 -4.57 0.0 204 492 210 410 0.41463 4.2e-005 245 3 M0714_1.02 (ENSG00000235187)_(Mus_musculus)_(DBD_1.00) NDBCGGAWRY 1.1e0000 1.4e-003 -6.57 0.0 185 491 278 597 0.37678 5.7e-006 245 3 M0891_1.02 TLX2 NTAAWNNNNN 3.7e-001 4.9e-004 -7.62 0.0 71 491 84 352 0.14460 2.0e-006 245 3 M1359_1.02 (MYPOP)_(Mus_musculus)_(DBD_0.97) NWTTGCGCCR 5.6e-002 7.4e-005 -9.51 0.0 237 491 291 487 0.48269 3.0e-007 245 3 M1970_1.02 NFIC TGCCAA 1.1e-004 1.5e-007 -15.74 0.0 63 495 131 600 0.12727 5.9e-010 247 3 M2277_1.02 FLI1 RCAGGAAGTGR 3.4e0000 4.6e-003 -5.39 0.0 212 490 305 588 0.43265 1.9e-005 244 3 M2278_1.02 FOS DVTGASTCATB 3.5e-002 4.7e-005 -9.96 0.0 208 490 233 425 0.42449 1.9e-007 244 3 M2292_1.02 JUND DRTGASTCATS 1.8e-002 2.4e-005 -10.65 0.0 166 490 186 399 0.33878 9.7e-008 244 3 M2299_1.02 (MYF5)_(Mus_musculus)_(DBD_0.90) NRNRRCAGCTGSN 9.0e0000 1.2e-002 -4.42 0.0 252 488 343 574 0.51639 5.0e-005 243 3 M4344_1.02 (ARID2)_(Saccharomyces_cerevisiae)_(DBD_0.26) SGTTGCYA 7.2e0000 9.6e-003 -4.64 0.0 79 493 126 558 0.16024 3.9e-005 246 3 M4427_1.02 CTCF NYGGCCASCAGRKGGCRSYVB 6.3e-004 8.4e-007 -13.99 0.0 146 480 211 492 0.30417 3.5e-009 239 3 M4462_1.02 GABPA VVCCGGAAGTG 8.7e-005 1.2e-007 -15.97 0.0 178 490 268 544 0.36327 4.8e-010 244 3 M4522_1.02 ELK4 CCGGAAGYGS 7.8e-007 1.0e-009 -20.68 0.0 193 491 303 564 0.39308 4.3e-012 245 3 M4526_1.02 SMARCC1 DSRVDGTGASTCABV 3.6e-002 4.8e-005 -9.95 0.0 200 486 241 454 0.41152 2.0e-007 242 3 M4537_1.02 E2F4 SGCGGGAARWTBVRR 4.3e0000 5.7e-003 -5.17 0.0 176 486 234 520 0.36214 2.4e-005 242 3 M4565_1.02 FOSL2 VDGGATGASTCAYH 1.4e-001 1.8e-004 -8.61 0.0 219 487 240 422 0.44969 7.5e-007 243 3 M4612_1.02 CTCFL CCRSCAGGGGGCGCY 1.3e-008 1.8e-011 -24.74 0.0 156 486 237 491 0.32099 7.4e-014 242 3 M4619_1.02 FOSL1 BGGTGASTCAK 3.0e-002 3.9e-005 -10.14 0.0 196 490 207 390 0.40000 1.6e-007 244 3 M4623_1.02 JUNB NDRTGASTCATNYHY 8.9e-001 1.2e-003 -6.74 0.0 168 486 186 410 0.34568 4.9e-006 242 3 M5116_1.02 (ATOH8)_(Drosophila_melanogaster)_(DBD_0.70) RCCACCTGK 4.9e0000 6.5e-003 -5.03 0.0 52 492 93 577 0.10569 2.7e-005 245 3 M5292_1.02 ATF4 GKATGAYGCAATM 5.1e-001 6.8e-004 -7.30 0.0 186 488 209 426 0.38115 2.8e-006 243 3 M5302_1.02 BATF3 TGATGACGTCATCA 2.6e0000 3.5e-003 -5.65 0.0 209 487 69 109 0.42916 1.4e-005 243 3 M5377_1.02 ELF4 AACCCGGAAGTR 6.9e0000 9.2e-003 -4.69 0.0 265 489 290 457 0.54192 3.8e-005 244 3 M5398_1.02 ERF ACCGGAAGTR 5.3e0000 7.0e-003 -4.96 0.0 213 491 278 532 0.43381 2.9e-005 245 3 M5587_1.02 JDP2 ATGASTCAT 1.5e0000 2.1e-003 -6.19 0.0 166 492 168 377 0.33740 8.4e-006 245 3 M5660_1.02 NFIA TTGGCANNDTGCCAR 5.5e-027 7.4e-030 -67.08 0.0 54 486 118 328 0.11111 3.1e-032 242 3 M5662_1.02 NFIB TTGGCAHNDTGCCAR 8.7e-027 1.2e-029 -66.62 0.0 54 486 119 334 0.11111 4.8e-032 242 3 M5664_1.02 NFIX TTGGCANNNNGCCAR 7.9e-022 1.1e-024 -55.21 0.0 54 486 137 462 0.11111 4.4e-027 242 3 M6174_1.02 CEBPZ AGCCAATSAGH 2.5e0000 3.3e-003 -5.72 0.0 234 490 263 455 0.47755 1.3e-005 244 3 M6184_1.02 CUX1 RBRSNDATCGATSB 7.1e-005 9.4e-008 -16.18 0.0 87 487 146 500 0.17864 3.9e-010 243 3 M6192_1.02 E2F3 SSCGCSAAAC 6.0e0000 8.0e-003 -4.83 0.0 163 491 191 450 0.33198 3.3e-005 245 3 M6194_1.02 E2F5 SGCGCSAAAH 8.1e0000 1.1e-002 -4.53 0.0 97 491 118 423 0.19756 4.4e-005 245 3 M6207_1.02 ELK1 RCCGGAAGT 3.8e-002 5.1e-005 -9.89 0.0 190 492 292 597 0.38618 2.1e-007 245 3 M6208_1.02 ELK3 VMCHGGAARTSC 2.1e-001 2.8e-004 -8.18 0.0 259 489 345 547 0.52965 1.1e-006 244 3 M6213_1.02 ERG ACCGGAARTSM 3.1e0000 4.1e-003 -5.50 0.0 192 490 257 534 0.39184 1.7e-005 244 3 M6221_1.02 ETS2 VMVGGAAGTKS 9.4e0000 1.3e-002 -4.38 0.0 262 490 369 600 0.53469 5.2e-005 244 3 M6222_1.02 ETV4 SAGGAAGY 3.5e0000 4.6e-003 -5.38 0.0 213 493 310 600 0.43205 1.9e-005 246 3 M6226_1.02 FEV CAGGAARTDA 9.9e0000 1.3e-002 -4.33 0.0 181 491 255 567 0.36864 5.4e-005 245 3 M6228_1.02 FOSB CTGACTCAYV 9.9e0000 1.3e-002 -4.33 0.0 221 491 285 532 0.45010 5.4e-005 245 3 M6276_1.02 HINFP DMSNHMGCGGACGTTV 8.9e0000 1.2e-002 -4.43 0.0 321 485 265 349 0.66186 4.9e-005 242 3 M6333_1.02 MAFG MATGACT 2.2e-001 2.9e-004 -8.14 0.0 166 494 245 567 0.33603 1.2e-006 246 3 M6339_1.02 MECP2 YYCCGGS 9.9e-003 1.3e-005 -11.23 0.0 268 494 356 542 0.54251 5.4e-008 246 3 M6348_1.02 MTF1 MGKGCCGTGYGCAAARS 6.0e0000 8.0e-003 -4.83 0.0 4 484 13 394 0.00826 3.3e-005 241 3 M6359_1.02 NFE2L1 NATGACD 7.2e-002 9.6e-005 -9.25 0.0 166 494 250 572 0.33603 3.9e-007 246 3 M6360_1.02 NFE2L2 VRTGACTCAGCA 3.1e0000 4.1e-003 -5.49 0.0 165 489 240 569 0.33742 1.7e-005 244 3 M6380_1.02 NOBOX HTAATTRSY 3.7e0000 5.0e-003 -5.31 0.0 84 492 122 500 0.17073 2.0e-005 245 3 M6513_1.02 TFAP4 RYCAGCTGYGG 3.8e0000 5.0e-003 -5.29 0.0 194 490 260 537 0.39592 2.1e-005 244 3 M6525_1.02 TLX1 YGBYAAKDWGS 2.1e-002 2.8e-005 -10.49 0.0 38 490 83 590 0.07755 1.1e-007 244 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).