# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 ACACACACACACACACACA MEME-1 ACACACACACACACACACA 8.6e-016 1.2e-018 -41.30 0.0 118 482 156 320 0.24481 4.8e-021 240 1 TGTGTGTGTGTGTGTGTGTG MEME-2 TGTGTGTGTGTGTGTGTGTG 2.3e-011 3.0e-014 -31.12 0.0 101 481 149 375 0.20998 1.3e-016 240 1 GTGTGTGTG MEME-4 GTGTGTGTG 2.5e-012 3.3e-015 -33.34 0.0 116 492 158 360 0.23577 1.4e-017 245 1 ACACACCACACACA MEME-6 ACACACCACACACA 4.7e0000 6.4e-003 -5.05 0.0 129 487 98 256 0.26489 2.6e-005 243 1 TGTGTGTGTGT MEME-9 TGTGTGTGTGT 3.8e-012 5.2e-015 -32.90 0.0 112 490 170 409 0.22857 2.1e-017 244 3 M2310_1.02 RUNX2 MAAACCACARAMMMM 8.9e-002 1.2e-004 -9.03 0.0 244 486 336 554 0.50206 4.9e-007 242 3 M5875_1.02 TBX1 AGGTGTGAAAAAAGGTGTGA 6.8e0000 9.1e-003 -4.70 0.0 215 481 178 319 0.44699 3.8e-005 240 3 M5883_1.02 TBX20 TCACACSTTCACACCT 1.4e-004 1.9e-007 -15.50 0.0 115 485 152 410 0.23711 7.7e-010 242 3 M5981_1.02 ZSCAN4 TTTTCAGKGTGTGCA 1.9e-004 2.5e-007 -15.19 0.0 74 486 103 374 0.15226 1.0e-009 242 3 M6200_1.02 EGR3 WGAGTGGGYGT 2.7e-008 3.6e-011 -24.04 0.0 120 490 202 518 0.24490 1.5e-013 244 3 M6212_1.02 EPAS1 CMCACGYAYDCAC 2.3e-007 3.1e-010 -21.90 0.0 94 488 169 525 0.19262 1.3e-012 243 3 M6265_1.02 GLI2 GTGGGTGGTCY 4.9e-001 6.6e-004 -7.32 0.0 124 490 145 406 0.25306 2.7e-006 244 3 M6266_1.02 GLI3 BTGGGTGGTCY 5.0e-002 6.7e-005 -9.61 0.0 82 490 130 508 0.16735 2.7e-007 244 3 M6323_1.02 KLF3 HRCYWGGGTGKGGCT 7.0e-002 9.4e-005 -9.27 0.0 122 486 178 507 0.25103 3.9e-007 242 3 M6456_1.02 RREB1 DKGKKKGKGGKTGKTTKGGGKT 2.3e-008 3.1e-011 -24.21 0.0 75 479 145 507 0.15658 1.3e-013 239 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).