# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 VMAGCCCAACCA MEME-1 VMAGCCCAACCA 2.7e-267 3.6e-270 -620.43 0.0 69 489 465 591 0.14110 1.5e-272 244 1 CCCRSCTCAGCCCMSC MEME-5 CCCRSCTCAGCCCMSC 2.5e-011 3.4e-014 -31.03 0.0 135 485 204 442 0.27835 1.4e-016 242 1 SWGCCCARC MEME-6 SWGCCCARC 5.4e-209 7.2e-212 -486.17 0.0 64 492 396 562 0.13008 2.9e-214 245 1 CCCAKCYCAGCYCAGC MEME-8 CCCAKCYCAGCYCAGC 1.5e-006 2.0e-009 -20.05 0.0 91 485 65 153 0.18763 8.1e-012 242 2 GYTGGGCD DREME-1 GYTGGGCT 1.0e-214 1.3e-217 -499.37 0.0 81 493 390 472 0.16430 5.4e-220 246 2 GRCCAAC DREME-2 GGCCAAC 1.8e-028 2.4e-031 -70.51 0.0 52 494 78 159 0.10526 9.7e-034 246 2 GAGVCCA DREME-5 GAGSCCA 9.7e-015 1.3e-017 -38.89 0.0 138 494 145 265 0.27935 5.2e-020 246 2 AGCCCMG DREME-6 AGCCCMG 5.2e-030 7.0e-033 -74.05 0.0 62 494 113 260 0.12551 2.8e-035 246 2 AGCCCBAC DREME-7 AGCCCYAC 7.0e-145 9.3e-148 -338.55 0.0 81 493 269 329 0.16430 3.8e-150 246 3 M0178_1.02 (ASCL2)_(Mus_musculus)_(DBD_0.98) NVCAGCTGBN 8.7e0000 1.2e-002 -4.45 0.0 11 491 29 567 0.02240 4.8e-005 245 3 M0405_1.02 (KLF7)_(Mus_musculus)_(DBD_1.00) DGGGCGKGGY 3.0e-005 3.9e-008 -17.05 0.0 145 491 247 590 0.29532 1.6e-010 245 3 M0432_1.02 (ZFP161)_(Mus_musculus)_(DBD_1.00) NNCGYGCHH 3.1e0000 4.1e-003 -5.49 0.0 20 492 29 296 0.04065 1.7e-005 245 3 M0443_1.02 (KLF12)_(Mus_musculus)_(DBD_1.00) DGGGYGKGKY 1.1e-002 1.5e-005 -11.13 0.0 147 491 236 586 0.29939 6.0e-008 245 3 M1871_1.02 (KLF2)_(Mus_musculus)_(DBD_0.95) DGGGYGKGGC 2.1e-013 2.7e-016 -35.83 0.0 107 491 214 562 0.21792 1.1e-018 245 3 M1890_1.02 NFYA AGVSYKCTGATTGGTBSR 2.4e0000 3.2e-003 -5.74 0.0 135 483 154 409 0.27950 1.3e-005 241 3 M1928_1.02 NFKB1 KGGRMTTTCCM 4.7e0000 6.3e-003 -5.07 0.0 38 490 69 537 0.07755 2.6e-005 244 3 M1929_1.02 TP53 CATGTCTGGRCATGY 9.2e0000 1.2e-002 -4.40 0.0 92 486 114 425 0.18930 5.1e-005 242 3 M1963_1.02 (ZFY)_(Mus_musculus)_(DBD_0.97) SSSGSCBVGGCCTS 4.7e-001 6.3e-004 -7.37 0.0 47 487 86 540 0.09651 2.6e-006 243 3 M2264_1.02 (ATOH1)_(Mus_musculus)_(DBD_1.00) RCCAKCTG 1.8e-002 2.3e-005 -10.66 0.0 75 493 135 570 0.15213 9.5e-008 246 3 M2301_1.02 NFYB VHMYBRRCCAATCAG 9.0e0000 1.2e-002 -4.42 0.0 72 486 100 461 0.14815 5.0e-005 242 3 M2321_1.02 TP63 NDRCAWGYHCARRCWTGYHY 5.5e-002 7.3e-005 -9.53 0.0 89 481 148 542 0.18503 3.0e-007 240 3 M2391_1.02 KLF5 DGGGHGGGGC 4.2e-003 5.7e-006 -12.08 0.0 55 491 107 560 0.11202 2.3e-008 245 3 M4473_1.02 PBX3 NBCDGCCAATSRGVR 2.0e-007 2.7e-010 -22.03 0.0 68 486 142 562 0.13992 1.1e-012 242 3 M4532_1.02 MYC CCACGTGSYY 3.9e0000 5.3e-003 -5.25 0.0 31 491 56 497 0.06314 2.2e-005 245 3 M4536_1.02 E2F1 VRRVRGVGCGCGCRS 4.5e0000 6.0e-003 -5.12 0.0 184 486 199 418 0.37860 2.5e-005 242 3 M4840_1.02 (FEZF1)_(Drosophila_melanogaster)_(DBD_0.91) AAAWGMGCAWC 3.1e-008 4.2e-011 -23.89 0.0 66 490 142 569 0.13469 1.7e-013 244 3 M5209_1.02 (SP5)_(Drosophila_melanogaster)_(DBD_0.93) GKGGGCGKRKC 2.9e-002 3.9e-005 -10.15 0.0 134 490 203 540 0.27347 1.6e-007 244 3 M5497_1.02 GRHL1 AACCGGTYTAACCGGTT 2.7e0000 3.6e-003 -5.62 0.0 116 484 108 312 0.23967 1.5e-005 241 3 M5512_1.02 HIC2 VSYGGGCAY 8.3e-004 1.1e-006 -13.72 0.0 64 492 129 597 0.13008 4.5e-009 245 3 M5592_1.02 KLF14 ARGKGGGCGTGGYM 3.2e-002 4.3e-005 -10.06 0.0 129 487 167 444 0.26489 1.8e-007 243 3 M5593_1.02 KLF16 GGGGGCGTGKC 3.2e-001 4.3e-004 -7.74 0.0 216 490 297 549 0.44082 1.8e-006 244 3 M5660_1.02 NFIA TTGGCANNDTGCCAR 6.4e0000 8.6e-003 -4.76 0.0 138 486 127 328 0.28395 3.6e-005 242 3 M5662_1.02 NFIB TTGGCAHNDTGCCAR 4.7e0000 6.2e-003 -5.08 0.0 138 486 129 332 0.28395 2.6e-005 242 3 M5664_1.02 NFIX TTGGCANNNNGCCAR 1.6e0000 2.2e-003 -6.14 0.0 94 486 130 471 0.19342 8.9e-006 242 3 M5805_1.02 SCRT2 RWGCAACAGGTGB 6.5e0000 8.7e-003 -4.75 0.0 156 488 160 384 0.31967 3.6e-005 243 3 M5856_1.02 SP8 RGKGGGCGTGGY 1.8e-009 2.4e-012 -26.77 0.0 83 489 172 573 0.16973 9.7e-015 244 3 M5959_1.02 ZBTB49 TTTCGCYTGGCVSGTCA 7.6e-003 1.0e-005 -11.50 0.0 54 484 52 213 0.11157 4.2e-008 241 3 M5962_1.02 ZBTB7C NTYGGTGGTCGY 9.2e-001 1.2e-003 -6.70 0.0 53 489 95 555 0.10838 5.0e-006 244 3 M5965_1.02 ZIC4 DCDCMGCRGGGGGYC 8.2e-002 1.1e-004 -9.12 0.0 154 486 211 498 0.31687 4.5e-007 242 3 M5971_1.02 ZKSCAN3 TCGAGGYTAGMCCA 5.8e-006 7.7e-009 -18.68 0.0 41 487 56 258 0.08419 3.2e-011 243 3 M6131_1.02 (TFCP2L1)_(Mus_musculus)_(DBD_0.95) CYRGYTYHRDCYRGYTYNRDC 2.9e-001 3.9e-004 -7.86 0.0 68 480 121 561 0.14167 1.6e-006 239 3 M6185_1.02 CXXC1 CGKTGKY 2.6e-002 3.4e-005 -10.28 0.0 80 494 141 572 0.16194 1.4e-007 246 3 M6191_1.02 E2F2 GGCGCGAAAC 2.4e-001 3.2e-004 -8.06 0.0 109 491 123 372 0.22200 1.3e-006 245 3 M6192_1.02 E2F3 SSCGCSAAAC 1.9e-011 2.6e-014 -31.29 0.0 77 491 134 419 0.15682 1.0e-016 245 3 M6199_1.02 EGR2 DGVGTGGGCGG 1.1e-008 1.4e-011 -24.97 0.0 42 490 105 564 0.08571 5.9e-014 244 3 M6201_1.02 EGR4 GGSGGYRGGGM 7.9e-004 1.1e-006 -13.76 0.0 26 490 61 504 0.05306 4.3e-009 244 3 M6210_1.02 ENO1 YDSMCACRTGSYB 6.3e-001 8.3e-004 -7.09 0.0 86 488 143 564 0.17623 3.4e-006 243 3 M6240_1.02 FOXI1 RRCCAATCAVAR 1.2e-007 1.6e-010 -22.55 0.0 67 489 118 446 0.13701 6.6e-013 244 3 M6259_1.02 GCM1 HWNATGCKGGYMBK 7.1e-004 9.5e-007 -13.87 0.0 71 487 136 569 0.14579 3.9e-009 243 3 M6264_1.02 GLI1 BTGGGTGGTCY 1.4e-020 1.9e-023 -52.34 0.0 80 490 199 584 0.16327 7.6e-026 244 3 M6265_1.02 GLI2 GTGGGTGGTCY 2.7e-024 3.6e-027 -60.89 0.0 56 490 149 489 0.11429 1.5e-029 244 3 M6266_1.02 GLI3 BTGGGTGGTCY 5.2e-012 6.9e-015 -32.61 0.0 80 490 171 558 0.16327 2.8e-017 244 3 M6274_1.02 HIC1 GGGKTGCCC 5.3e0000 7.0e-003 -4.96 0.0 32 492 63 562 0.06504 2.9e-005 245 3 M6322_1.02 KLF1 CAGGGTGKGGC 2.6e-004 3.4e-007 -14.89 0.0 68 490 132 570 0.13878 1.4e-009 244 3 M6323_1.02 KLF3 HRCYWGGGTGKGGCT 1.5e-004 1.9e-007 -15.45 0.0 56 486 113 549 0.11523 8.0e-010 242 3 M6324_1.02 KLF4 DGGGYGKGGC 8.1e-011 1.1e-013 -29.86 0.0 71 491 158 574 0.14460 4.4e-016 245 3 M6346_1.02 MLXIPL VCACGVSGKKGBCMCRTGC 5.3e0000 7.0e-003 -4.96 0.0 198 482 205 400 0.41079 2.9e-005 240 3 M6350_1.02 MYB CMGTTRD 2.1e-006 2.8e-009 -19.70 0.0 34 494 81 520 0.06883 1.1e-011 246 3 M6373_1.02 NFYC YAGCCAATSAGVGS 5.6e-004 7.5e-007 -14.11 0.0 57 487 114 561 0.11704 3.1e-009 243 3 M6418_1.02 PITX2 DBTAATCCMA 4.2e-001 5.6e-004 -7.49 0.0 57 491 106 584 0.11609 2.3e-006 245 3 M6449_1.02 REL DKGGRNWTTCCV 1.1e0000 1.5e-003 -6.53 0.0 219 489 302 557 0.44785 6.0e-006 244 3 M6456_1.02 RREB1 DKGKKKGKGGKTGKTTKGGGKT 4.1e-002 5.4e-005 -9.82 0.0 59 479 101 493 0.12317 2.3e-007 239 3 M6459_1.02 RUNX3 AACCRCAAAMCCCV 2.6e0000 3.4e-003 -5.68 0.0 45 487 77 512 0.09240 1.4e-005 243 3 M6468_1.02 SNAI1 SCAGGTGK 8.7e0000 1.2e-002 -4.45 0.0 39 493 74 588 0.07911 4.8e-005 246 3 M6482_1.02 SP3 VGVVGGGGGCGGGGCBRGSS 2.8e-001 3.7e-004 -7.89 0.0 157 481 229 540 0.32640 1.6e-006 240 3 M6514_1.02 TFCP2 SCCWGMNMDSRCCRGA 3.5e0000 4.7e-003 -5.36 0.0 143 485 219 583 0.29485 1.9e-005 242 3 M6527_1.02 TWIST1 MCCCAGGTGK 1.6e-001 2.1e-004 -8.46 0.0 41 491 78 530 0.08350 8.7e-007 245 3 M6537_1.02 YBX1 BSKGATTSSCY 3.0e-003 4.0e-006 -12.42 0.0 70 490 136 596 0.14286 1.7e-008 244 3 M6547_1.02 ZFX SVGSSSSSCAGGCCBVGSC 2.0e-002 2.7e-005 -10.53 0.0 78 482 130 516 0.16183 1.1e-007 240 3 M6548_1.02 ZIC1 KGGGWGGTV 1.3e0000 1.8e-003 -6.33 0.0 80 492 136 586 0.16260 7.3e-006 245 3 M6549_1.02 ZIC2 DGGGTGGTC 3.7e-001 5.0e-004 -7.61 0.0 104 492 174 596 0.21138 2.0e-006 245 3 M6550_1.02 ZIC3 BGGGTGGYC 9.5e0000 1.3e-002 -4.37 0.0 80 492 133 590 0.16260 5.2e-005 245 3 M6559_1.02 ZNF589 CCMASGGKWWYWRCCS 4.4e0000 5.9e-003 -5.13 0.0 127 485 192 565 0.26186 2.4e-005 242 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).