# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 SGSTCCCWGGGGDGS MEME-1 SGSTCCCWGGGGDGS 5.7e-227 7.6e-230 -527.56 0.0 142 486 1654 2813 0.29218 3.2e-232 242 1 CYCCTGCTG MEME-2 CYCCTGCTG 5.7e-068 7.6e-071 -161.45 0.0 110 492 759 1840 0.22358 3.1e-073 245 2 CCCHDGGG DREME-1 CCCYDGGG 4.3e-151 5.7e-154 -352.86 0.0 143 493 962 1563 0.29006 2.3e-156 246 2 CAGCRGGR DREME-2 CAGCAGGR 5.2e-053 7.0e-056 -127.00 0.0 87 493 391 993 0.17647 2.8e-058 246 2 CWCCCD DREME-4 CWCCCD 1.1e-016 1.4e-019 -43.38 0.0 135 495 1038 2936 0.27273 5.9e-022 247 2 CNGGGA DREME-5 CNGGGA 6.5e-014 8.7e-017 -36.98 0.0 133 495 975 2827 0.26869 3.5e-019 247 2 CCHGGAGA DREME-7 CCWGGAGA 3.2e-009 4.3e-012 -26.17 0.0 89 493 175 556 0.18053 1.7e-014 246 2 GCGCWS DREME-8 GCGCWS 8.4e-010 1.1e-012 -27.52 0.0 237 495 1149 2034 0.47879 4.5e-015 247 3 M0085_1.02 (TFAP2E)_(Mus_musculus)_(DBD_0.99) THGCCYSVGG 1.4e-028 1.9e-031 -70.74 0.0 151 491 1223 2964 0.30754 7.8e-034 245 3 M0405_1.02 (KLF7)_(Mus_musculus)_(DBD_1.00) DGGGCGKGGY 6.1e-001 8.2e-004 -7.10 0.0 227 491 1505 2988 0.46232 3.4e-006 245 3 M0422_1.02 (ZIC5)_(Mus_musculus)_(DBD_0.99) SYRGGGGGTM 6.7e-056 9.0e-059 -133.65 0.0 125 491 1169 2980 0.25458 3.7e-061 245 3 M0428_1.02 (ZNF691)_(Mus_musculus)_(DBD_0.97) RKGAGYAC 2.8e-001 3.7e-004 -7.90 0.0 113 493 786 2952 0.22921 1.5e-006 246 3 M0443_1.02 (KLF12)_(Mus_musculus)_(DBD_1.00) DGGGCGKGKY 1.5e-001 2.0e-004 -8.50 0.0 225 491 1500 2987 0.45825 8.3e-007 245 3 M0609_1.02 DNMT1 NNCCGCNNNN 8.2e-001 1.1e-003 -6.82 0.0 407 491 1781 2059 0.82892 4.5e-006 245 3 M1838_1.02 TFAP2A NHBDGCCYSAGGGCA 3.3e-012 4.4e-015 -33.05 0.0 146 486 1074 2870 0.30041 1.8e-017 242 3 M1871_1.02 (KLF2)_(Mus_musculus)_(DBD_0.95) DGGGYGKGGC 1.9e-001 2.6e-004 -8.25 0.0 161 491 1072 2899 0.32790 1.1e-006 245 3 M1928_1.02 NFKB1 KGGRMTTTCCM 4.8e0000 6.5e-003 -5.04 0.0 86 490 558 2713 0.17551 2.7e-005 244 3 M1968_1.02 EBF1 TCCCWGGGGRV 1.2e-129 1.6e-132 -303.49 0.0 92 490 1125 2933 0.18776 6.4e-135 244 3 M2264_1.02 (ATOH1)_(Mus_musculus)_(DBD_1.00) RCCAKCTG 1.5e-002 2.0e-005 -10.82 0.0 205 493 1332 2869 0.41582 8.1e-008 246 3 M2273_1.02 E2F6 RGGCGGGARRV 1.1e0000 1.5e-003 -6.50 0.0 282 490 1807 2937 0.57551 6.2e-006 244 3 M2323_1.02 ZBTB33 SARVTCTCGCGAGAV 1.8e0000 2.4e-003 -6.02 0.0 182 486 829 1965 0.37449 1.0e-005 242 3 M2387_1.02 SREBF1 RTGGGGTGAB 2.6e-001 3.5e-004 -7.97 0.0 433 491 2326 2554 0.88187 1.4e-006 245 3 M2391_1.02 KLF5 DGGGHGGGGC 5.9e-001 7.9e-004 -7.14 0.0 281 491 1804 2941 0.57230 3.2e-006 245 3 M4427_1.02 CTCF NYGGCCASCAGRKGGCRSYVB 6.2e-023 8.3e-026 -57.75 0.0 188 480 1274 2555 0.39167 3.5e-028 239 3 M4444_1.02 RELA DGGGRMTTTCCMVN 1.2e0000 1.6e-003 -6.46 0.0 95 487 584 2536 0.19507 6.5e-006 243 3 M4479_1.02 TCF12 VSAGCAGSTGB 4.5e-002 6.0e-005 -9.73 0.0 132 490 903 2896 0.26939 2.4e-007 244 3 M4525_1.02 TFAP2C NGCCYSAGGSCANDB 1.1e-022 1.4e-025 -57.22 0.0 134 486 1068 2894 0.27572 5.8e-028 242 3 M4536_1.02 E2F1 VRRVRGVGCGCGCRS 3.0e-001 4.0e-004 -7.83 0.0 220 486 1316 2642 0.45267 1.6e-006 242 3 M4612_1.02 CTCFL CCRSCAGGGGGCGCY 7.2e-051 9.7e-054 -122.07 0.0 158 486 1260 2668 0.32510 4.0e-056 242 3 M4681_1.02 BACH2 TGCTGAGTCA 6.1e0000 8.2e-003 -4.81 0.0 107 491 481 1870 0.21792 3.4e-005 245 3 M5116_1.02 (ATOH8)_(Drosophila_melanogaster)_(DBD_0.70) RCCACCTGK 1.4e0000 1.9e-003 -6.25 0.0 154 492 1009 2875 0.31301 7.9e-006 245 3 M5209_1.02 (SP5)_(Drosophila_melanogaster)_(DBD_0.93) GKGGGCGKRKC 2.1e-001 2.8e-004 -8.17 0.0 336 490 2087 2873 0.68571 1.2e-006 244 3 M5490_1.02 GLIS1 GCDTCGTGGGGGGTCK 7.7e0000 1.0e-002 -4.57 0.0 99 485 150 546 0.20412 4.3e-005 242 3 M5491_1.02 GLIS2 CDYYGCGGGGGGTC 7.5e-034 1.0e-036 -82.89 0.0 129 487 886 2266 0.26489 4.1e-039 243 3 M5593_1.02 KLF16 GGGGGCGTGKC 9.0e-002 1.2e-004 -9.03 0.0 390 490 2395 2878 0.79592 4.9e-007 244 3 M5660_1.02 NFIA TTGGCANNDTGCCAR 1.3e-002 1.7e-005 -11.00 0.0 310 486 966 1369 0.63786 6.9e-008 242 3 M5662_1.02 NFIB TTGGCAHNDTGCCAR 4.9e-002 6.6e-005 -9.63 0.0 310 486 977 1392 0.63786 2.7e-007 242 3 M5664_1.02 NFIX TTGGCANNNNGCCAR 5.2e0000 6.9e-003 -4.97 0.0 242 486 1150 2122 0.49794 2.9e-005 242 3 M5856_1.02 SP8 RGKGGGCGTGGY 1.3e0000 1.7e-003 -6.36 0.0 343 489 2144 2905 0.70143 7.1e-006 244 3 M5962_1.02 ZBTB7C NTCGGTGGTCGY 1.1e-001 1.4e-004 -8.87 0.0 91 489 634 2848 0.18609 5.8e-007 244 3 M5965_1.02 ZIC4 DCDCMGCGGGGGGYC 2.7e-153 3.6e-156 -357.93 0.0 122 486 1388 2869 0.25103 1.5e-158 242 3 M5977_1.02 ZNF740 GTGGGGGGGK 5.2e0000 6.9e-003 -4.98 0.0 319 491 1918 2796 0.64969 2.8e-005 245 3 M6144_1.02 TFAP2B BCCCBCRGGC 4.1e-007 5.5e-010 -21.32 0.0 151 491 1085 2952 0.30754 2.2e-012 245 3 M6146_1.02 TFAP2D ACGSGCCBCRGGCS 5.2e-002 6.9e-005 -9.58 0.0 125 487 730 2416 0.25667 2.9e-007 243 3 M6150_1.02 ARNT2 GYSYSCCACGNC 5.7e0000 7.6e-003 -4.88 0.0 231 489 1502 2949 0.47239 3.1e-005 244 3 M6191_1.02 E2F2 GGCGCGAAAC 2.0e0000 2.7e-003 -5.90 0.0 253 491 1335 2389 0.51527 1.1e-005 245 3 M6264_1.02 GLI1 BTGGGTGGTCY 8.7e-005 1.2e-007 -15.97 0.0 134 490 908 2782 0.27347 4.8e-010 244 3 M6265_1.02 GLI2 GTGGGTGGTCY 8.8e-006 1.2e-008 -18.26 0.0 102 490 532 1974 0.20816 4.8e-011 244 3 M6266_1.02 GLI3 BTGGGTGGTCB 2.1e-009 2.8e-012 -26.59 0.0 124 490 847 2652 0.25306 1.2e-014 244 3 M6267_1.02 GLIS3 GYGGGGGGTM 6.7e-018 9.0e-021 -46.16 0.0 145 491 1111 2919 0.29532 3.7e-023 245 3 M6270_1.02 NHLH1 RRGGMCGCAGCTGMKMCCCV 1.8e0000 2.4e-003 -6.02 0.0 137 481 726 2223 0.28482 1.0e-005 240 3 M6271_1.02 HES1 KGKCKCGTGBCKB 7.3e-001 9.7e-004 -6.93 0.0 188 488 1250 2936 0.38525 4.0e-006 243 3 M6274_1.02 HIC1 GGGKTGCCC 2.3e-009 3.1e-012 -26.52 0.0 188 492 1295 2863 0.38211 1.2e-014 245 3 M6322_1.02 KLF1 CAGGGTGKGGC 1.3e-005 1.8e-008 -17.86 0.0 128 490 914 2905 0.26122 7.2e-011 244 3 M6323_1.02 KLF3 HRCYWGGGTGKGGCT 7.5e-002 1.0e-004 -9.20 0.0 108 486 697 2649 0.22222 4.2e-007 242 3 M6324_1.02 KLF4 DGGGYGKGGC 2.1e-001 2.8e-004 -8.19 0.0 281 491 1808 2938 0.57230 1.1e-006 245 3 M6325_1.02 KLF6 GGGGGCKG 3.0e-001 4.1e-004 -7.81 0.0 277 493 1788 2958 0.56187 1.6e-006 246 3 M6326_1.02 KLF8 CMGGGKGTG 2.5e-032 3.3e-035 -79.39 0.0 108 492 927 2872 0.21951 1.4e-037 245 3 M6339_1.02 MECP2 YYCCGGS 4.8e-010 6.4e-013 -28.08 0.0 126 494 734 2226 0.25506 2.6e-015 246 3 M6346_1.02 MLXIPL VCACGVSGKKGBCMCRTGC 4.1e-001 5.5e-004 -7.50 0.0 82 482 395 1869 0.17012 2.3e-006 240 3 M6353_1.02 MYF6 GCAGSTG 1.3e0000 1.8e-003 -6.34 0.0 138 494 932 2950 0.27935 7.1e-006 246 3 M6355_1.02 MYOG YRACAGCTGCWGC 5.3e-003 7.1e-006 -11.85 0.0 144 488 945 2754 0.29508 2.9e-008 243 3 M6420_1.02 PLAG1 GGRGGSMHNDVKAGGGG 1.1e-002 1.5e-005 -11.10 0.0 116 484 819 2899 0.23967 6.3e-008 241 3 M6422_1.02 PLAGL1 CRGGGGGCCC 5.1e-033 6.9e-036 -80.97 0.0 141 491 1143 2858 0.28717 2.8e-038 245 3 M6468_1.02 SNAI1 SCAGGTGK 1.5e-006 2.0e-009 -20.04 0.0 157 493 1111 2944 0.31846 8.1e-012 246 3 M6469_1.02 SNAI2 BCAGGTG 8.9e-002 1.2e-004 -9.04 0.0 122 494 851 2971 0.24696 4.8e-007 246 3 M6513_1.02 TFAP4 RYCAGCTGYGG 3.1e-003 4.2e-006 -12.39 0.0 204 490 1265 2696 0.41633 1.7e-008 244 3 M6527_1.02 TWIST1 MCCCAGGTGK 3.0e-011 4.0e-014 -30.84 0.0 103 491 721 2597 0.20978 1.6e-016 245 3 M6535_1.02 WT1 GMGGGGGCGKGGG 6.3e-001 8.5e-004 -7.07 0.0 274 488 1722 2854 0.56148 3.5e-006 243 3 M6544_1.02 HIVEP1 VGGGATTTCCCA 3.3e0000 4.4e-003 -5.43 0.0 89 489 567 2650 0.18200 1.8e-005 244 3 M6547_1.02 ZFX SVGSSSSSCAGGCCBVGSC 2.0e0000 2.7e-003 -5.91 0.0 340 482 2065 2784 0.70539 1.1e-005 240 3 M6548_1.02 ZIC1 KGGGWGGTS 5.3e-017 7.1e-020 -44.09 0.0 92 492 773 2985 0.18699 2.9e-022 245 3 M6549_1.02 ZIC2 KGGGTGGTC 2.4e-011 3.2e-014 -31.07 0.0 74 492 617 2986 0.15041 1.3e-016 245 3 M6550_1.02 ZIC3 BGGGTGGYC 3.0e-024 4.0e-027 -60.78 0.0 148 492 1186 2982 0.30081 1.6e-029 245 3 M6553_1.02 ZNF219 GDGGGGGGYGGA 8.5e-002 1.1e-004 -9.09 0.0 153 489 1014 2846 0.31288 4.6e-007 244 3 M6558_1.02 ZNF423 GCACCCTWGGGTGYC 1.2e-060 1.6e-063 -144.58 0.0 100 486 348 699 0.20576 6.7e-066 242 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).