# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 AAAAAAAAAAAAAAAAAAAARA MEME-1 AAAAAAAAAAAAAAAAAAAARA 3.0e-075 4.0e-078 -178.21 0.0 163 479 402 544 0.34029 1.7e-080 239 1 GCCGAGATCGCGCCACTGCACTCCAGCCTGG MEME-2 GCCGAGATCGCGCCACTGCACTCCAGCCTGG 1.1e-008 1.5e-011 -24.93 0.0 284 470 165 194 0.60426 6.3e-014 234 2 DAAAAAAA DREME-1 RAAAAAAA 8.9e-100 1.2e-102 -234.69 0.0 169 493 422 523 0.34280 4.8e-105 246 2 ACTCCAKC DREME-2 ACTCCAGC 1.8e-008 2.4e-011 -24.46 0.0 223 493 118 158 0.45233 9.7e-014 246 2 CGAYCTC DREME-9 CGAYCTC 1.7e0000 2.3e-003 -6.08 0.0 412 494 116 120 0.83401 9.3e-006 246 3 M0436_1.02 (ZNF35)_(Mus_musculus)_(DBD_0.96) TTRTTKDHYN 7.9e-039 1.1e-041 -94.35 0.0 171 491 377 600 0.34827 4.3e-044 245 3 M0442_1.02 (ZBTB3)_(Mus_musculus)_(DBD_1.00) NNTGCAGYG 4.9e0000 6.5e-003 -5.03 0.0 348 492 468 599 0.70732 2.7e-005 245 3 M0718_1.02 FOXK1 NNRTMAACAH 7.6e0000 1.0e-002 -4.59 0.0 163 491 240 583 0.33198 4.2e-005 245 3 M0728_1.02 (FOXJ1)_(Mus_musculus)_(DBD_1.00) NRTAAACAAANN 1.2e-011 1.6e-014 -31.79 0.0 195 489 339 598 0.39877 6.4e-017 244 3 M0736_1.02 (FOXK2)_(Mus_musculus)_(DBD_0.90) RTAAACAA 4.4e-002 5.9e-005 -9.74 0.0 195 493 298 598 0.39554 2.4e-007 246 3 M1157_1.02 (HOXB9)_(PBM_CONSTRUCTS)_(DBD_1.00) WTTWATKRBN 6.6e0000 8.8e-003 -4.73 0.0 219 491 308 583 0.44603 3.6e-005 245 3 M1882_1.02 IRF1 AAANNGAAAGTGAAASYRRRN 1.2e-044 1.6e-047 -107.78 0.0 168 480 377 576 0.35000 6.5e-050 239 3 M2267_1.02 CDX2 TTTTATKRCHB 1.2e-004 1.7e-007 -15.62 0.0 210 490 309 553 0.42857 6.8e-010 244 3 M2283_1.02 FOXP1 HWWADGTAAACAAAR 2.2e-055 3.0e-058 -132.46 0.0 184 486 422 594 0.37860 1.2e-060 242 3 M2307_1.02 PRDM1 DRAAAGTGAAAGTGR 7.4e-003 1.0e-005 -11.52 0.0 202 486 310 588 0.41564 4.1e-008 242 3 M2313_1.02 (SOX6)_(Mus_musculus)_(DBD_1.00) CCWTTGTYYY 3.4e-002 4.5e-005 -10.00 0.0 149 491 237 587 0.30346 1.9e-007 245 3 M2319_1.02 TCF7L2 TBYCTTTGAWSTYN 6.7e-002 9.0e-005 -9.31 0.0 167 487 245 549 0.34292 3.7e-007 243 3 M2385_1.02 FOXP2 RWGTAAACAVR 7.6e-006 1.0e-008 -18.41 0.0 170 490 278 580 0.34694 4.1e-011 244 3 M4452_1.02 BATF TYYYRWWATGASTCA 1.2e-003 1.7e-006 -13.30 0.0 180 486 264 536 0.37037 6.9e-009 242 3 M4453_1.02 BCL11A ADGRGGAASTGAAAV 1.8e0000 2.4e-003 -6.03 0.0 168 486 251 581 0.34568 1.0e-005 242 3 M4467_1.02 MEF2C NDKCYAAAAATAGMH 3.6e-001 4.8e-004 -7.65 0.0 156 486 239 577 0.32099 2.0e-006 242 3 M4545_1.02 ZNF683 DRAAAGTGAAAGTGV 4.0e0000 5.4e-003 -5.22 0.0 192 486 279 582 0.39506 2.2e-005 242 3 M4551_1.02 ZNF274 YTCAYACTGGAGAGAAA 1.1e-001 1.5e-004 -8.81 0.0 222 484 171 283 0.45868 6.2e-007 241 3 M4635_1.02 STAT2 GAAANYGAAACTDAA 7.2e-020 9.7e-023 -50.69 0.0 170 486 325 579 0.34979 4.0e-025 242 3 M4840_1.02 (FEZF1)_(Drosophila_melanogaster)_(DBD_0.91) AAAWGMGCAWC 6.4e-007 8.5e-010 -20.88 0.0 216 490 337 577 0.44082 3.5e-012 244 3 M5322_1.02 CPEB1 YTTTTATT 6.9e-004 9.3e-007 -13.89 0.0 171 493 277 598 0.34686 3.8e-009 246 3 M5530_1.02 HOMEZ TWTAATCGTTTT 3.4e-010 4.6e-013 -28.41 0.0 157 489 249 509 0.32106 1.9e-015 244 3 M5544_1.02 HOXC10 DTTTWATKDB 2.9e-006 3.8e-009 -19.38 0.0 207 491 330 590 0.42159 1.6e-011 245 3 M5551_1.02 HOXC12 TTTTATTRC 1.6e-025 2.2e-028 -63.69 0.0 210 492 394 596 0.42683 8.9e-031 245 3 M5553_1.02 HOXC13 CYAATAAAAH 2.1e-003 2.8e-006 -12.78 0.0 203 491 309 584 0.41344 1.2e-008 245 3 M5555_1.02 HOXD11 RTCGTAAAAH 5.8e-002 7.8e-005 -9.46 0.0 203 491 263 501 0.41344 3.2e-007 245 3 M5557_1.02 HOXD12 GTAATAAAA 2.8e-022 3.8e-025 -56.23 0.0 218 492 395 595 0.44309 1.6e-027 245 3 M5697_1.02 ONECUT3 DTTATYGATTTTTY 1.0e-008 1.3e-011 -25.03 0.0 147 487 237 518 0.30185 5.5e-014 243 3 M5865_1.02 SPIC NAAAAGVGGAAGTA 1.7e-004 2.3e-007 -15.27 0.0 143 487 235 568 0.29363 9.6e-010 243 3 M5976_1.02 ZNF713 TTCGTGGCATTYTTCTA 2.0e-001 2.6e-004 -8.25 0.0 166 484 92 176 0.34298 1.1e-006 241 3 M6037_1.02 (IRX1)_(Mus_musculus)_(DBD_1.00) TTTKTCATGTWR 4.3e0000 5.8e-003 -5.15 0.0 245 489 310 525 0.50102 2.4e-005 244 3 M6119_1.02 SPI1 RAAAAGAGGAAGTGV 8.1e-001 1.1e-003 -6.82 0.0 206 486 284 547 0.42387 4.5e-006 242 3 M6147_1.02 ARID3A TWWAWTTTGATWYYVWTTAATH 3.7e-026 5.0e-029 -65.17 0.0 149 479 286 509 0.31106 2.1e-031 239 3 M6163_1.02 BPTF KKTBTTGTKKKS 8.0e-052 1.1e-054 -124.27 0.0 197 489 434 600 0.40286 4.4e-057 244 3 M6206_1.02 ELF5 AHMAGGAWRTW 6.0e0000 8.0e-003 -4.82 0.0 442 490 551 581 0.90204 3.3e-005 244 3 M6225_1.02 MECOM WAGAYAAGATAANAKA 3.6e0000 4.8e-003 -5.33 0.0 145 485 181 465 0.29897 2.0e-005 242 3 M6226_1.02 FEV CAGGAARTDA 9.5e-002 1.3e-004 -8.97 0.0 377 491 477 560 0.76782 5.2e-007 245 3 M6228_1.02 FOSB CTGACTCAYV 1.4e0000 1.9e-003 -6.27 0.0 175 491 249 558 0.35642 7.7e-006 245 3 M6235_1.02 FOXC1 CYWAAGTAAACAWHG 4.2e-002 5.7e-005 -9.78 0.0 228 486 317 549 0.46914 2.3e-007 242 3 M6236_1.02 FOXC2 YCTRDSWAAACAAAC 3.4e-002 4.6e-005 -10.00 0.0 172 486 241 519 0.35391 1.9e-007 242 3 M6237_1.02 FOXD3 AAACAAACA 6.5e-032 8.7e-035 -78.42 0.0 176 492 368 600 0.35772 3.6e-037 245 3 M6238_1.02 FOXF1 WAAATAAACAW 1.4e-002 1.9e-005 -10.88 0.0 190 490 284 571 0.38776 7.7e-008 244 3 M6241_1.02 FOXJ2 WAAAYAAACA 4.3e0000 5.8e-003 -5.15 0.0 177 491 257 580 0.36049 2.4e-005 245 3 M6242_1.02 FOXJ3 TAAACAWWAAMMA 1.4e-030 1.8e-033 -75.39 0.0 210 488 391 567 0.43033 7.5e-036 243 3 M6244_1.02 FOXM1 RWAAWCAMWCAAV 6.5e-004 8.7e-007 -13.96 0.0 160 488 262 592 0.32787 3.6e-009 243 3 M6245_1.02 FOXO1 AAAWWVWAAACAAVHH 3.0e-038 4.0e-041 -93.02 0.0 169 485 371 590 0.34845 1.7e-043 242 3 M6246_1.02 FOXO3 MKGWAAACAARYM 3.3e-003 4.4e-006 -12.34 0.0 180 488 287 597 0.36885 1.8e-008 243 3 M6247_1.02 FOXO4 MRTAAACAA 1.0e-008 1.4e-011 -25.02 0.0 180 492 305 590 0.36585 5.5e-014 245 3 M6249_1.02 FOXP3 AAWCAMATT 1.1e-006 1.5e-009 -20.34 0.0 192 492 309 584 0.39024 6.0e-012 245 3 M6250_1.02 FOXQ1 AAATAAACAATD 1.3e-006 1.7e-009 -20.18 0.0 177 489 270 534 0.36196 7.1e-012 244 3 M6251_1.02 FUBP1 TYGTNTTTTTTT 4.2e-023 5.6e-026 -58.14 0.0 161 489 328 597 0.32924 2.3e-028 244 3 M6299_1.02 HOXC6 AAAGTAATAAATCAT 6.7e-008 9.0e-011 -23.13 0.0 174 486 203 374 0.35802 3.7e-013 242 3 M6301_1.02 HOXD10 AATTAAARCA 2.6e-008 3.5e-011 -24.07 0.0 181 491 306 593 0.36864 1.4e-013 245 3 M6308_1.02 IRF2 SGAAAGYGAAASYV 3.0e-008 4.0e-011 -23.94 0.0 153 487 269 586 0.31417 1.6e-013 243 3 M6309_1.02 IRF3 GGAAAGBGAAASBRRRA 1.0e-019 1.4e-022 -50.35 0.0 160 484 317 591 0.33058 5.6e-025 241 3 M6311_1.02 IRF5 KAAAGGRAARCMAAAWSWGA 3.9e-039 5.2e-042 -95.06 0.0 163 481 308 469 0.33888 2.2e-044 240 3 M6312_1.02 IRF7 GAAASYGAAA 7.3e-003 9.7e-006 -11.54 0.0 163 491 261 596 0.33198 4.0e-008 245 3 M6313_1.02 IRF8 GRGRAAVTGAAASYR 2.2e0000 3.0e-003 -5.82 0.0 130 486 207 597 0.26749 1.2e-005 242 3 M6314_1.02 IRF9 GAAAGCGAAAYT 1.3e-001 1.7e-004 -8.68 0.0 211 489 253 464 0.43149 7.0e-007 244 3 M6363_1.02 NFATC2 RWTTTTCCA 2.2e0000 2.9e-003 -5.84 0.0 4 492 17 596 0.00813 1.2e-005 245 3 M6365_1.02 NFATC4 WADTTTTCCH 4.5e-001 6.0e-004 -7.42 0.0 125 491 202 595 0.25458 2.4e-006 245 3 M6377_1.02 NKX2-8 TTCAAGKRC 9.1e0000 1.2e-002 -4.41 0.0 440 492 523 555 0.89431 5.0e-005 245 3 M6391_1.02 NR2E3 TGACTTTTGACTTT 1.5e-005 2.1e-008 -17.70 0.0 149 487 250 576 0.30595 8.5e-011 243 3 M6392_1.02 NR2F6 YYMNNTGAMCTTTGWCCY 5.6e-001 7.4e-004 -7.20 0.0 171 483 256 572 0.35404 3.1e-006 241 3 M6399_1.02 ONECUT2 DKSWTKWTATKGATTTTWYYT 2.8e-025 3.8e-028 -63.14 0.0 170 480 299 492 0.35417 1.6e-030 239 3 M6438_1.02 PROP1 RASHAATTAAHWTVR 6.0e0000 8.1e-003 -4.82 0.0 142 486 201 539 0.29218 3.3e-005 242 3 M6473_1.02 SOX17 CAAMAATNHHCATTGTCS 8.6e0000 1.2e-002 -4.46 0.0 167 483 158 353 0.34576 4.8e-005 241 3 M6474_1.02 SOX18 GGAMRAVAACAAWKBDWDS 5.0e-008 6.7e-011 -23.43 0.0 170 482 275 545 0.35270 2.8e-013 240 3 M6476_1.02 SOX4 GAGAACAAAGSG 5.1e-001 6.8e-004 -7.29 0.0 145 489 227 589 0.29652 2.8e-006 244 3 M6478_1.02 SOX9 ARAACAATRGR 1.7e0000 2.3e-003 -6.07 0.0 176 490 253 564 0.35918 9.4e-006 244 3 M6485_1.02 SPIB ARAAASMGGAAS 5.0e-005 6.7e-008 -16.51 0.0 139 489 240 593 0.28425 2.8e-010 244 3 M6490_1.02 SRY DAAACAAWR 2.9e-002 3.8e-005 -10.17 0.0 166 492 263 599 0.33740 1.6e-007 245 3 M6509_1.02 TEAD4 AAAAAYAKCYCT 3.2e-007 4.3e-010 -21.56 0.0 173 489 282 567 0.35378 1.8e-012 244 3 M6557_1.02 ZNF384 GSAAAAAVYMBS 2.2e-022 3.0e-025 -56.48 0.0 157 489 321 598 0.32106 1.2e-027 244 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).