# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 GGTGTGAACNGKBKNG MEME-1 GGTGTGAACNGKBKNG 5.9e-161 7.9e-164 -375.56 0.0 93 485 422 592 0.19175 3.3e-166 242 1 CCAGCTACTCRGGAGGCTGAGGCAGGAGA MEME-2 CCAGCTACTCRGGAGGCTGAGGCAGGAGA 3.6e-003 4.9e-006 -12.23 0.0 82 472 36 82 0.17373 2.1e-008 235 1 CACACAYACACA MEME-3 CACACAYACACA 2.5e-008 3.4e-011 -24.10 0.0 57 489 87 331 0.11656 1.4e-013 244 2 RGTGDGAA DREME-1 RGTGTGAA 7.2e-136 9.7e-139 -317.79 0.0 69 493 294 441 0.13996 3.9e-141 246 2 GTGTGADY DREME-2 GTGTGAGY 7.8e-081 1.0e-083 -191.07 0.0 93 493 270 439 0.18864 4.3e-086 246 2 CCGCCYCC DREME-3 CCGCCTCC 5.8e-001 7.8e-004 -7.16 0.0 71 493 36 115 0.14402 3.2e-006 246 2 ACTGCAAG DREME-4 ACTGCAAG 1.8e-003 2.4e-006 -12.94 0.0 91 493 79 233 0.18458 9.7e-009 246 2 CTACTCRG DREME-10 CTACTCRG 4.8e-001 6.4e-004 -7.36 0.0 193 493 110 199 0.39148 2.6e-006 246 3 M0398_1.02 (ZSCAN10)_(Mus_musculus)_(DBD_0.82) NGKRAGTGCNN 6.0e-001 8.0e-004 -7.13 0.0 114 490 183 579 0.23265 3.3e-006 244 3 M0405_1.02 (KLF7)_(Mus_musculus)_(DBD_1.00) DGGGCGKGGY 2.7e0000 3.6e-003 -5.62 0.0 49 491 90 579 0.09980 1.5e-005 245 3 M0442_1.02 (ZBTB3)_(Mus_musculus)_(DBD_1.00) NNTGCAGYG 1.5e0000 2.0e-003 -6.21 0.0 108 492 174 585 0.21951 8.2e-006 245 3 M0443_1.02 (KLF12)_(Mus_musculus)_(DBD_1.00) DGGGYGKGKY 4.2e0000 5.7e-003 -5.17 0.0 49 491 91 587 0.09980 2.3e-005 245 3 M1628_1.02 (TBX10)_(Mus_musculus)_(DBD_0.87) AGGTGTGAANN 7.5e-125 1.0e-127 -292.42 0.0 92 490 384 600 0.18776 4.1e-130 244 3 M2281_1.02 FOXH1 BNSAATCCACA 4.5e0000 6.0e-003 -5.12 0.0 196 490 258 529 0.40000 2.5e-005 244 3 M2387_1.02 SREBF1 RTGGGGTGAB 1.6e-014 2.1e-017 -38.40 0.0 99 491 203 549 0.20163 8.6e-020 245 3 M2388_1.02 SREBF2 RTGGGGTGAY 4.0e-020 5.4e-023 -51.27 0.0 55 491 148 540 0.11202 2.2e-025 245 3 M4484_1.02 ZNF143 CTGGGARTTGTAGTY 5.3e0000 7.2e-003 -4.94 0.0 88 486 96 357 0.18107 3.0e-005 242 3 M4569_1.02 HSF1 GTCSYGGGTTCGADTCCC 1.2e0000 1.6e-003 -6.42 0.0 73 483 59 223 0.15114 6.8e-006 241 3 M5628_1.02 MGA AGGTGTGA 9.8e-099 1.3e-101 -232.28 0.0 97 493 360 599 0.19675 5.4e-104 246 3 M5660_1.02 NFIA TTGGCANNDTGCCAR 2.6e-001 3.5e-004 -7.95 0.0 152 486 113 248 0.31276 1.5e-006 242 3 M5662_1.02 NFIB TTGGCAHNDTGCCAR 3.4e-001 4.6e-004 -7.68 0.0 152 486 116 257 0.31276 1.9e-006 242 3 M5873_1.02 TBR1 AGGTGTGAAA 1.3e-090 1.7e-093 -213.61 0.0 61 491 281 594 0.12424 6.9e-096 245 3 M5875_1.02 TBX1 AGGTGTGAAAAAAGGTGTGA 1.2e-011 1.6e-014 -31.76 0.0 61 481 100 331 0.12682 6.7e-017 240 3 M5880_1.02 TBX15 AGGTGTGAAATTCACACCT 6.0e-003 8.0e-006 -11.73 0.0 120 482 43 79 0.24896 3.4e-008 240 3 M5882_1.02 TBX19 DTTMRCACVTAGGTGTGAAW 1.1e-003 1.5e-006 -13.39 0.0 71 481 88 327 0.14761 6.4e-009 240 3 M5883_1.02 TBX20 TCACACSTTCACACCT 2.9e-043 3.9e-046 -104.56 0.0 67 485 194 467 0.13814 1.6e-048 242 3 M5889_1.02 TBX21 GGTGTGAHWTCACACC 1.0e-028 1.4e-031 -71.08 0.0 101 485 177 355 0.20825 5.6e-034 242 3 M5896_1.02 TBX4 AGGTGTGA 2.5e-066 3.4e-069 -157.67 0.0 57 493 241 599 0.11562 1.4e-071 246 3 M5979_1.02 ZNF75A TGTGGGAAAAGC 1.2e-002 1.6e-005 -11.07 0.0 45 489 81 474 0.09202 6.4e-008 244 3 M5981_1.02 ZSCAN4 TTTTCAGKGTGTGCA 6.8e-006 9.1e-009 -18.52 0.0 108 486 141 379 0.22222 3.7e-011 242 3 M6212_1.02 EPAS1 CMCACGYAYDCAC 1.8e-006 2.5e-009 -19.82 0.0 104 488 186 551 0.21311 1.0e-011 243 3 M6323_1.02 KLF3 HRCYWGGGTGKGGCT 8.7e-001 1.2e-003 -6.75 0.0 32 486 64 535 0.06584 4.8e-006 242 3 M6326_1.02 KLF8 CAGGGKGTG 1.8e-009 2.5e-012 -26.73 0.0 60 492 136 567 0.12195 1.0e-014 245 3 M6348_1.02 MTF1 MGKGCCGTGYGCAAARS 1.5e-001 2.0e-004 -8.53 0.0 52 484 82 440 0.10744 8.2e-007 241 3 M6376_1.02 NKX2-5 TYAAGTG 2.4e-003 3.2e-006 -12.66 0.0 132 494 217 582 0.26721 1.3e-008 246 3 M6379_1.02 NKX3-2 ARYTAAGTGGV 6.5e0000 8.8e-003 -4.74 0.0 166 490 240 571 0.33878 3.6e-005 244 3 M6410_1.02 PAX6 TSAWGCGTRAA 9.1e-006 1.2e-008 -18.23 0.0 64 490 132 574 0.13061 5.0e-011 244 3 M6456_1.02 RREB1 DKGKKKGKGGKTGKTTKGGGKT 2.7e0000 3.6e-003 -5.61 0.0 181 479 225 475 0.37787 1.5e-005 239 3 M6499_1.02 RBPJ CGTGGGAAM 1.0e-022 1.4e-025 -57.25 0.0 90 492 221 588 0.18293 5.6e-028 245 3 M6503_1.02 TBX2 GKSRCDBYTCACACCTVTGWDKBCA 3.0e-009 4.1e-012 -26.23 0.0 64 476 124 461 0.13445 1.7e-014 237 3 M6505_1.02 TBX5 AGGTGTGA 1.6e-070 2.1e-073 -167.33 0.0 97 493 321 599 0.19675 8.7e-076 246 3 M6515_1.02 TFDP1 AWWKRGCGGGAAAY 1.7e0000 2.3e-003 -6.07 0.0 219 487 217 387 0.44969 9.6e-006 243 3 M6519_1.02 TGIF1 MWGSTGACACCTSMCA 1.1e-010 1.5e-013 -29.54 0.0 71 485 162 592 0.14639 6.1e-016 242 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).