# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 GAAGGATGARTAGGAGTT MEME-1 GAAGGATGARTAGGAGTT 6.7e-388 9.0e-391 -898.12 0.0 67 483 518 551 0.13872 3.7e-393 241 1 GAGYTGGGYTTT MEME-2 GAGYTGGGYTTT 3.4e-217 4.6e-220 -505.05 0.0 65 489 414 585 0.13292 1.9e-222 244 1 GGCTTCMYRGAGGAGG MEME-3 GGCTTCMYRGAGGAGG 9.8e-048 1.3e-050 -114.86 0.0 103 485 245 452 0.21237 5.4e-053 242 2 RCTCCTA DREME-1 ACTCCTA 6.7e-287 9.0e-290 -665.55 0.0 76 494 437 486 0.15385 3.7e-292 246 2 CAADRCCC DREME-2 CAAARCCC 1.1e-204 1.5e-207 -476.24 0.0 59 493 300 361 0.11968 6.0e-210 246 2 CATCCTK DREME-3 CATCCTT 3.1e-078 4.1e-081 -185.09 0.0 36 494 136 255 0.07287 1.7e-083 246 2 CCAKGMAG DREME-4 CCAGGMAG 5.4e-006 7.2e-009 -18.74 0.0 145 493 91 169 0.29412 2.9e-011 246 2 AAGBCTTC DREME-5 AAGSCTTC 4.7e-019 6.3e-022 -48.82 0.0 135 493 77 100 0.27383 2.5e-024 246 2 ATGCCCY DREME-6 ATGCCCY 5.2e-007 7.0e-010 -21.08 0.0 96 494 67 151 0.19433 2.8e-012 246 2 CTWGGCA DREME-7 CTWGGCA 6.4e-002 8.6e-005 -9.36 0.0 96 494 50 129 0.19433 3.5e-007 246 2 AHCTGGCA DREME-8 AHCTGGCA 6.5e-001 8.7e-004 -7.05 0.0 59 493 25 77 0.11968 3.5e-006 246 2 ATGTCMC DREME-9 ATGTCMC 3.6e-005 4.8e-008 -16.85 0.0 74 494 38 86 0.14980 1.9e-010 246 3 M0395_1.02 (ZNF187)_(Mus_musculus)_(DBD_0.88) GTACTAAT 1.2e0000 1.6e-003 -6.46 0.0 37 493 72 559 0.07505 6.4e-006 246 3 M0428_1.02 (ZNF691)_(Mus_musculus)_(DBD_0.97) RKGAGYAC 1.8e0000 2.4e-003 -6.03 0.0 39 493 78 599 0.07911 9.8e-006 246 3 M0594_1.02 (LIN54)_(Gallus_gallus)_(DBD_0.98) DTTTRAATH 1.2e-013 1.6e-016 -36.40 0.0 34 492 95 504 0.06911 6.3e-019 245 3 M1358_1.02 (TERF2)_(Mus_musculus)_(DBD_0.92) NAACCCTAV 1.9e-013 2.6e-016 -35.90 0.0 46 492 121 551 0.09350 1.0e-018 245 3 M1605_1.02 (SOX1)_(Mus_musculus)_(DBD_1.00) ATTSWHNNNN 1.1e-015 1.4e-018 -41.10 0.0 35 491 110 574 0.07128 5.8e-021 245 3 M1915_1.02 (ZNF76)_(Xenopus_laevis)_(DBD_0.84) KCRWKGMATBMTGGGARDTV 7.6e-006 1.0e-008 -18.40 0.0 37 481 90 558 0.07692 4.2e-011 240 3 M1928_1.02 NFKB1 KGGRMTTTCCM 8.9e-017 1.2e-019 -43.57 0.0 74 490 175 559 0.15102 4.9e-022 244 3 M1955_1.02 STAT1 TTTCYRGGAAA 1.5e-013 2.1e-016 -36.12 0.0 122 490 222 521 0.24898 8.4e-019 244 3 M2277_1.02 FLI1 RCAGGAAGTGR 1.2e0000 1.6e-003 -6.43 0.0 174 490 259 584 0.35510 6.6e-006 244 3 M2319_1.02 TCF7L2 TBYCTTTGAWSTYN 3.6e-003 4.9e-006 -12.23 0.0 63 487 121 567 0.12936 2.0e-008 243 3 M2390_1.02 EHF SAGGAAGK 1.6e0000 2.2e-003 -6.12 0.0 169 493 246 571 0.34280 9.0e-006 246 3 M4444_1.02 RELA DGGGRMTTTCCMVN 6.3e-014 8.5e-017 -37.00 0.0 63 487 147 533 0.12936 3.5e-019 243 3 M4478_1.02 STAT3 SHBVTSAYTTCCRGKAAAYG 1.1e-001 1.5e-004 -8.82 0.0 99 481 151 507 0.20582 6.2e-007 240 3 M4484_1.02 ZNF143 CTGGGARTTGTAGTY 4.9e-010 6.6e-013 -28.05 0.0 42 486 89 420 0.08642 2.7e-015 242 3 M4692_1.02 SIX5 ACTACAAYTC 5.1e-058 6.9e-061 -138.53 0.0 53 491 196 488 0.10794 2.8e-063 245 3 M5345_1.02 DMBX1 NHTAATCCBH 1.8e-001 2.4e-004 -8.33 0.0 35 491 73 568 0.07128 9.8e-007 245 3 M5363_1.02 E2F8 TTTCCCGCCAAA 6.9e0000 9.2e-003 -4.68 0.0 149 489 94 215 0.30470 3.8e-005 244 3 M5501_1.02 GSC2 NYTAATCCBH 6.3e-001 8.5e-004 -7.08 0.0 35 491 71 567 0.07128 3.5e-006 245 3 M5753_1.02 PROX1 YAAGACGYCTTA 1.0e-002 1.4e-005 -11.21 0.0 97 489 98 296 0.19836 5.6e-008 244 3 M5972_1.02 ZNF410 GANTATTATGGGATGKM 8.8e-006 1.2e-008 -18.25 0.0 26 484 32 155 0.05372 4.9e-011 241 3 M5974_1.02 ZNF524 GGGTTCRAGGGT 1.1e-002 1.5e-005 -11.09 0.0 33 489 63 455 0.06748 6.3e-008 244 3 M5981_1.02 ZSCAN4 TTTTCAGKGTGTGCA 7.6e-010 1.0e-012 -27.61 0.0 50 486 91 369 0.10288 4.2e-015 242 3 M6111_1.02 (ZNF652)_(Mus_musculus)_(DBD_1.00) NBAAAGGGTTAAH 3.5e-003 4.7e-006 -12.26 0.0 60 488 85 376 0.12295 2.0e-008 243 3 M6140_1.02 AIRE HTTGGWWWWWWTGGDTWH 5.9e-095 7.9e-098 -223.59 0.0 55 483 272 581 0.11387 3.3e-100 241 3 M6154_1.02 ATF5 TAAGGRAGARGK 7.7e-014 1.0e-016 -36.81 0.0 107 489 224 588 0.21881 4.2e-019 244 3 M6159_1.02 BCL6 TTCCWRGAAWGYHYWH 8.0e-040 1.1e-042 -96.64 0.0 111 485 287 576 0.22887 4.4e-045 242 3 M6166_1.02 CDC5L RWTAYRTTAAMWCVC 5.0e-001 6.7e-004 -7.30 0.0 26 486 50 464 0.05350 2.8e-006 242 3 M6167_1.02 CDX1 HCATAAAD 6.3e-005 8.4e-008 -16.29 0.0 35 493 85 581 0.07099 3.4e-010 246 3 M6187_1.02 DDIT3 GGGGATTGCABBB 6.9e-004 9.3e-007 -13.89 0.0 90 488 161 565 0.18443 3.8e-009 243 3 M6204_1.02 ELF2 TDNCAGGAAGTRRVT 6.9e0000 9.3e-003 -4.68 0.0 188 486 264 562 0.38683 3.8e-005 242 3 M6221_1.02 ETS2 VMVGGAAGTKS 1.6e0000 2.2e-003 -6.13 0.0 142 490 222 595 0.28980 8.9e-006 244 3 M6222_1.02 ETV4 SAGGAAGY 3.6e-002 4.8e-005 -9.95 0.0 197 493 300 595 0.39959 1.9e-007 246 3 M6257_1.02 GATA5 WVANWGATAABTYRRHK 1.2e-013 1.6e-016 -36.39 0.0 48 484 123 533 0.09917 6.5e-019 241 3 M6269_1.02 HBP1 AYYCATTGA 5.4e0000 7.2e-003 -4.93 0.0 44 492 77 537 0.08943 3.0e-005 245 3 M6291_1.02 HOXA1 CATCCATCMA 3.6e-084 4.9e-087 -198.74 0.0 39 491 214 553 0.07943 2.0e-089 245 3 M6295_1.02 HOXB1 CCATCMATCW 9.7e-040 1.3e-042 -96.45 0.0 35 491 138 491 0.07128 5.3e-045 245 3 M6296_1.02 HOXB6 KKCATMAATCAWY 2.3e-015 3.1e-018 -40.32 0.0 24 488 72 412 0.04918 1.3e-020 243 3 M6297_1.02 HOXB7 MATYAATCAA 3.4e-004 4.5e-007 -14.61 0.0 37 491 72 448 0.07536 1.8e-009 245 3 M6298_1.02 HOXB8 BMATTAATCAA 1.1e-008 1.5e-011 -24.95 0.0 26 490 63 411 0.05306 6.0e-014 244 3 M6300_1.02 HOXC8 GSBHATYAATSAAR 6.5e-006 8.7e-009 -18.56 0.0 35 487 81 515 0.07187 3.6e-011 243 3 M6327_1.02 LEF1 CTTTGWW 1.5e-012 2.0e-015 -33.85 0.0 58 494 143 581 0.11741 8.1e-018 246 3 M6349_1.02 MYBL2 WYAACCKSYA 2.3e-022 3.1e-025 -56.42 0.0 47 491 148 592 0.09572 1.3e-027 245 3 M6361_1.02 NFATC1 AWGGAAWTTTCCD 4.9e-006 6.5e-009 -18.85 0.0 48 488 88 428 0.09836 2.7e-011 243 3 M6364_1.02 NFATC3 RDTTTTCCA 1.6e-007 2.2e-010 -22.25 0.0 86 492 172 582 0.17480 8.9e-013 245 3 M6365_1.02 NFATC4 WADTTTTCCH 9.2e-001 1.2e-003 -6.69 0.0 141 491 216 579 0.28717 5.1e-006 245 3 M6366_1.02 NFAT5 MAKGRANTTTTCCRS 8.6e-018 1.2e-020 -45.90 0.0 50 486 128 492 0.10288 4.8e-023 242 3 M6370_1.02 NFKB2 GRAATBYCCCT 3.6e-004 4.8e-007 -14.55 0.0 100 490 181 588 0.20408 2.0e-009 244 3 M6377_1.02 NKX2-8 TTCAAGKRC 2.9e-047 3.9e-050 -113.78 0.0 48 492 192 585 0.09756 1.6e-052 245 3 M6389_1.02 NR2C1 VTGACCTCYBRSC 2.2e-004 3.0e-007 -15.02 0.0 44 488 97 573 0.09016 1.2e-009 243 3 M6392_1.02 NR2F6 YYMNNTGAMCTTTGWCCY 1.8e-003 2.4e-006 -12.94 0.0 207 483 313 572 0.42857 1.0e-008 241 3 M6396_1.02 NR5A2 TRRCCTTGRV 8.7e-001 1.2e-003 -6.75 0.0 27 491 60 590 0.05499 4.8e-006 245 3 M6400_1.02 OTX1 BTAAKCCT 1.2e0000 1.6e-003 -6.44 0.0 21 493 48 562 0.04260 6.5e-006 246 3 M6401_1.02 OTX2 NYYTAATCCBWKHDM 2.5e-001 3.4e-004 -8.00 0.0 60 486 104 531 0.12346 1.4e-006 242 3 M6410_1.02 PAX6 TSAWGCGTRAA 2.6e-032 3.5e-035 -79.34 0.0 36 490 143 581 0.07347 1.4e-037 244 3 M6412_1.02 PBX1 VHMATCAATCAAWYH 6.9e-078 9.3e-081 -184.28 0.0 38 486 205 552 0.07819 3.8e-083 242 3 M6418_1.02 PITX2 DBTAATCCMA 1.7e-007 2.3e-010 -22.17 0.0 33 491 87 571 0.06721 9.6e-013 245 3 M6419_1.02 PKNOX1 MATCARTCAABYB 2.2e-011 3.0e-014 -31.15 0.0 56 488 132 548 0.11475 1.2e-016 243 3 M6420_1.02 PLAG1 GGRGGSMHNWVKAGGGG 5.8e-003 7.8e-006 -11.77 0.0 108 484 187 582 0.22314 3.2e-008 241 3 M6432_1.02 PPARD TGACCTTTVNCCTR 3.6e-001 4.8e-004 -7.63 0.0 171 487 260 585 0.35113 2.0e-006 243 3 M6446_1.02 RARG BTGACCTBYNGBYGAMCYCC 1.9e-002 2.5e-005 -10.59 0.0 53 481 107 579 0.11019 1.0e-007 240 3 M6448_1.02 RELB RGGGRMTTTCCH 6.0e-019 8.1e-022 -48.57 0.0 105 489 237 593 0.21472 3.3e-024 244 3 M6449_1.02 REL DKGGRNWTTCCV 3.1e0000 4.2e-003 -5.48 0.0 71 489 122 582 0.14519 1.7e-005 244 3 M6459_1.02 RUNX3 AACCRCAAAMCCCV 3.0e-008 4.0e-011 -23.94 0.0 31 487 80 512 0.06366 1.6e-013 243 3 M6491_1.02 STAT5A YTTCYVRGAAWT 1.9e-008 2.5e-011 -24.41 0.0 117 489 206 537 0.23926 1.0e-013 244 3 M6492_1.02 STAT5B DTTTCYDGGAATT 1.1e-007 1.5e-010 -22.63 0.0 112 488 170 447 0.22951 6.1e-013 243 3 M6496_1.02 STAT4 TTTCCMAGAAAAV 1.5e-008 2.0e-011 -24.63 0.0 110 488 202 552 0.22541 8.3e-014 243 3 M6506_1.02 TCF7 VHSCTTTGWWST 8.7e-006 1.2e-008 -18.26 0.0 175 489 279 568 0.35787 4.8e-011 244 3 M6532_1.02 VDR TGAMCYC 4.9e-010 6.5e-013 -28.06 0.0 62 494 146 598 0.12551 2.7e-015 246 3 M6545_1.02 HIVEP2 GGYDGGGWAACYSS 2.2e0000 3.0e-003 -5.81 0.0 81 487 139 590 0.16632 1.2e-005 243 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).