# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 MMTGCAGCW MEME-1 MMTGCAGCW 1.3e-103 1.7e-106 -243.51 0.0 98 492 368 599 0.19919 7.1e-109 245 1 GCYGCTGCTGCTGCTG MEME-2 GCYGCTGCTGCTGCTG 1.1e-023 1.4e-026 -59.51 0.0 83 485 120 251 0.17113 5.9e-029 242 1 RGSAGCAGCAGCAGCAGCAGC MEME-3 RGSAGCAGCAGCAGCAGCAGC 3.7e-021 4.9e-024 -53.67 0.0 80 480 71 118 0.16667 2.1e-026 239 1 SYTGGCASGSHGCCAR MEME-4 SYTGGCASGSHGCCAR 2.3e-005 3.1e-008 -17.30 0.0 147 485 184 405 0.30309 1.3e-010 242 1 CTGCTGC MEME-6 CTGCTGC 1.8e-030 2.4e-033 -75.11 0.0 80 494 163 374 0.16194 9.8e-036 246 1 GCAYRCAYGCAYGMAYRCACRCRSAMNCACA MEME-8 GCAYRCAYGCAYGMAYRCACRCRSAMNCACA 2.4e-003 3.2e-006 -12.66 0.0 56 470 21 46 0.11915 1.4e-008 234 1 BTKHAATGCWTTGTKK MEME-9 BTKHAATGCWTTGTKK 5.7e-004 7.7e-007 -14.08 0.0 81 485 77 239 0.16701 3.2e-009 242 1 TTMTTTNGMRWATTGCMTWKVWRTTSYCWCACMCTGSARRNYMTGCWSYT MEME-10 TTMTTTNGMRWATTGCMTWKVWRTTSYCWCACMCTGSARRNYMTGCWSYT 3.0e-002 4.0e-005 -10.12 0.0 49 451 7 7 0.10865 1.8e-007 225 2 HTGCAK DREME-1 HTGCAK 1.2e-062 1.5e-065 -149.23 0.0 83 495 278 577 0.16768 6.2e-068 247 2 GTAATK DREME-4 GTAATK 8.0e-004 1.1e-006 -13.75 0.0 107 495 96 255 0.21616 4.3e-009 247 3 M0178_1.02 (ASCL2)_(Mus_musculus)_(DBD_0.98) NVCAGCTGBN 1.6e-006 2.1e-009 -19.97 0.0 59 491 127 577 0.12016 8.6e-012 245 3 M0198_1.02 (SOHLH2)_(Mus_musculus)_(DBD_0.84) NRYNCGTGCN 1.9e-001 2.5e-004 -8.28 0.0 207 491 292 558 0.42159 1.0e-006 245 3 M0216_1.02 (NHLH2)_(Mus_musculus)_(DBD_1.00) NGCAGCTGYN 2.8e-013 3.8e-016 -35.51 0.0 75 491 173 586 0.15275 1.6e-018 245 3 M0300_1.02 (ATF2)_(Mus_musculus)_(DBD_1.00) NRTKACGTMA 4.5e-001 6.0e-004 -7.42 0.0 173 491 244 543 0.35234 2.4e-006 245 3 M0413_1.02 (ZBTB1)_(Mus_musculus)_(DBD_0.99) NDTGCGKGDN 2.9e-002 3.9e-005 -10.14 0.0 277 491 365 542 0.56415 1.6e-007 245 3 M0442_1.02 (ZBTB3)_(Mus_musculus)_(DBD_1.00) NNTGCAGYG 5.7e-031 7.6e-034 -76.26 0.0 88 492 238 599 0.17886 3.1e-036 245 3 M0603_1.02 CGBP NNNBCGK 4.5e-001 6.0e-004 -7.42 0.0 170 494 181 397 0.34413 2.4e-006 246 3 M0609_1.02 DNMT1 NNCCGMNNNN 8.7e0000 1.2e-002 -4.45 0.0 261 491 283 454 0.53157 4.8e-005 245 3 M0610_1.02 TET1 NNYRCGYWN 2.0e0000 2.7e-003 -5.92 0.0 290 492 283 408 0.58943 1.1e-005 245 3 M0897_1.02 HOXB13 DTTWAYDRBN 9.0e0000 1.2e-002 -4.42 0.0 121 491 175 543 0.24644 5.0e-005 245 3 M1007_1.02 (HOXA11)_(Mus_musculus)_(DBD_1.00) TTWAYKDBN 2.0e-003 2.6e-006 -12.84 0.0 122 492 91 214 0.24797 1.1e-008 245 3 M1281_1.02 (NAIF1)_(Xenopus_tropicalis)_(DBD_0.71) NNTACGYHN 7.9e0000 1.1e-002 -4.55 0.0 182 492 158 330 0.36992 4.3e-005 245 3 M1583_1.02 (BBX)_(Mus_musculus)_(DBD_0.99) TTCATTGA 8.5e0000 1.1e-002 -4.48 0.0 49 493 81 525 0.09939 4.6e-005 246 3 M1925_1.02 CEBPA DRTTRTGCAAT 4.0e-001 5.4e-004 -7.53 0.0 62 490 105 530 0.12653 2.2e-006 244 3 M1929_1.02 TP53 CATGTCTGGRCATGY 4.5e-002 6.0e-005 -9.72 0.0 210 486 219 390 0.43210 2.5e-007 242 3 M1970_1.02 NFIC TGCCAA 6.5e-001 8.8e-004 -7.04 0.0 259 495 366 594 0.52323 3.6e-006 247 3 M2267_1.02 CDX2 TTTTATKRCHB 9.7e-004 1.3e-006 -13.55 0.0 120 490 186 519 0.24490 5.3e-009 244 3 M2268_1.02 CEBPB KATTGCAYMAY 3.2e-002 4.3e-005 -10.06 0.0 58 490 100 504 0.11837 1.7e-007 244 3 M2278_1.02 FOS DVTGASTCATB 4.7e-001 6.3e-004 -7.37 0.0 188 490 226 462 0.38367 2.6e-006 244 3 M2287_1.02 (HOXC9)_(Mus_musculus)_(DBD_0.98) RGCMATAAATCAB 5.9e0000 7.9e-003 -4.84 0.0 190 488 240 502 0.38934 3.3e-005 243 3 M2289_1.02 JUN DDRATGATGTMAT 5.4e0000 7.2e-003 -4.94 0.0 256 488 292 473 0.52459 3.0e-005 243 3 M2292_1.02 JUND DRTGASTCATS 3.0e0000 4.0e-003 -5.52 0.0 246 490 267 444 0.50204 1.7e-005 244 3 M2299_1.02 (MYF5)_(Mus_musculus)_(DBD_0.90) NRNRRCAGCTGSN 1.3e-005 1.7e-008 -17.90 0.0 56 488 118 561 0.11475 6.9e-011 243 3 M2306_1.02 POU2F2 NDNATTTGCATRW 5.6e-003 7.5e-006 -11.81 0.0 132 488 194 508 0.27049 3.1e-008 243 3 M2321_1.02 TP63 NDRCAWGYHCARRCWTGYHY 1.8e-001 2.4e-004 -8.32 0.0 195 481 260 508 0.40541 1.0e-006 240 3 M4471_1.02 PAX5 BCAGYSRAGCGTGAC 5.0e-006 6.8e-009 -18.81 0.0 76 486 146 547 0.15638 2.8e-011 242 3 M4479_1.02 TCF12 VSAGCAGSTGB 9.7e-011 1.3e-013 -29.67 0.0 60 490 140 569 0.12245 5.3e-016 244 3 M4509_1.02 POU5F1 ATYTGCATRACAAWGRV 8.2e-003 1.1e-005 -11.42 0.0 66 484 112 496 0.13636 4.6e-008 241 3 M4565_1.02 FOSL2 VDGGATGASTCAYH 9.5e0000 1.3e-002 -4.36 0.0 195 487 216 438 0.40041 5.3e-005 243 3 M4572_1.02 MAFF TGCTGACTCAGCAWW 5.5e-002 7.3e-005 -9.52 0.0 60 486 91 434 0.12346 3.0e-007 242 3 M4623_1.02 JUNB NDRTGASTCATNYHY 2.1e0000 2.8e-003 -5.86 0.0 232 486 258 446 0.47737 1.2e-005 242 3 M4629_1.02 NFE2 VRTGACTCAGCANWWYB 1.6e-001 2.1e-004 -8.47 0.0 122 484 151 420 0.25207 8.7e-007 241 3 M4681_1.02 BACH2 TGCTGAGTCA 1.7e-001 2.2e-004 -8.40 0.0 145 491 181 449 0.29532 9.1e-007 245 3 M4708_1.02 TBP TATGCAAATA 4.9e-002 6.6e-005 -9.63 0.0 83 491 139 543 0.16904 2.7e-007 245 3 M4850_1.02 (TCF15)_(Drosophila_melanogaster)_(DBD_0.70) TKTWRTNKBBDYDMCATSTGK 2.9e0000 3.9e-003 -5.55 0.0 258 480 356 570 0.53750 1.6e-005 239 3 M4971_1.02 (FERD3L)_(Drosophila_melanogaster)_(DBD_0.89) GTVACAGVTG 1.3e0000 1.7e-003 -6.35 0.0 55 491 101 583 0.11202 7.1e-006 245 3 M5292_1.02 ATF4 RKATGAYGCAATM 6.7e-011 8.9e-014 -30.04 0.0 126 488 194 445 0.25820 3.7e-016 243 3 M5302_1.02 BATF3 TGATGACGTCATCA 6.0e0000 8.0e-003 -4.83 0.0 187 487 62 107 0.38398 3.3e-005 243 3 M5342_1.02 DLX4 NTAATTRN 3.2e0000 4.3e-003 -5.45 0.0 85 493 133 547 0.17241 1.7e-005 246 3 M5390_1.02 EN1 VBTAATTRSB 1.5e-003 2.0e-006 -13.11 0.0 99 491 165 541 0.20163 8.3e-009 245 3 M5414_1.02 ESX1 NNTAATTRRN 4.0e0000 5.4e-003 -5.23 0.0 103 491 158 557 0.20978 2.2e-005 245 3 M5551_1.02 HOXC12 TTTTATTRC 9.0e0000 1.2e-002 -4.42 0.0 22 492 46 551 0.04472 5.0e-005 245 3 M5571_1.02 ID4 DVCAGGTGYN 3.5e-001 4.6e-004 -7.68 0.0 65 491 116 569 0.13238 1.9e-006 245 3 M5583_1.02 ISL2 YTAAKTGC 8.0e0000 1.1e-002 -4.53 0.0 99 493 155 573 0.20081 4.4e-005 246 3 M5587_1.02 JDP2 ATGASTCAT 1.5e-003 2.1e-006 -13.09 0.0 222 492 256 436 0.45122 8.4e-009 245 3 M5623_1.02 MEOX1 VSTAATTANC 5.2e0000 7.0e-003 -4.96 0.0 107 491 153 520 0.21792 2.9e-005 245 3 M5627_1.02 MESP1 NVCAGGTGYD 1.5e-001 2.1e-004 -8.48 0.0 65 491 119 581 0.13238 8.4e-007 245 3 M5636_1.02 MSC AACAGCTGTT 1.1e0000 1.4e-003 -6.56 0.0 225 491 272 487 0.45825 5.8e-006 245 3 M5660_1.02 NFIA TTGGCANNDTGCCAR 2.0e-005 2.7e-008 -17.44 0.0 230 486 228 355 0.47325 1.1e-010 242 3 M5662_1.02 NFIB TTGGCAHNDTGCCAR 1.2e-005 1.7e-008 -17.91 0.0 160 486 179 362 0.32922 6.9e-011 242 3 M5664_1.02 NFIX TTGGCANNNHGCCAR 1.5e-004 2.0e-007 -15.40 0.0 160 486 220 474 0.32922 8.4e-010 242 3 M5689_1.02 NRL DWWNTGCTGAC 6.0e0000 8.0e-003 -4.82 0.0 124 490 195 595 0.25306 3.3e-005 244 3 M5702_1.02 PAX1 DKCABTCAWGCGTGACG 3.7e-008 5.0e-011 -23.72 0.0 158 484 130 232 0.32645 2.1e-013 241 3 M5711_1.02 PAX9 KKCASTCAWGCGTGACS 1.9e-010 2.6e-013 -28.98 0.0 158 484 115 188 0.32645 1.1e-015 241 3 M5729_1.02 POU2F3 ATTWGCATA 6.0e0000 8.0e-003 -4.83 0.0 86 492 131 537 0.17480 3.3e-005 245 3 M5740_1.02 POU4F1 ATGMATAATTAATG 3.7e0000 5.0e-003 -5.31 0.0 77 487 112 486 0.15811 2.0e-005 243 3 M5743_1.02 POU4F3 RTGMATWATTAATGAV 9.5e-001 1.3e-003 -6.67 0.0 73 485 107 468 0.15052 5.2e-006 242 3 M5804_1.02 SCRT1 RWGCAACAGGTGKBH 6.9e0000 9.2e-003 -4.69 0.0 80 486 100 414 0.16461 3.8e-005 242 3 M5805_1.02 SCRT2 RWGCAACAGGTGB 2.4e-003 3.3e-006 -12.63 0.0 82 488 114 408 0.16803 1.3e-008 243 3 M5815_1.02 SOX14 ACAATAMCATTG 8.3e0000 1.1e-002 -4.50 0.0 99 489 87 289 0.20245 4.6e-005 244 3 M5965_1.02 ZIC4 DCDCMGCRGGGGGYC 2.0e0000 2.6e-003 -5.95 0.0 192 486 241 490 0.39506 1.1e-005 242 3 M5998_1.02 (CREB5)_(Mus_musculus)_(DBD_1.00) DRTGACGTCATN 3.7e0000 5.0e-003 -5.30 0.0 291 489 208 292 0.59509 2.1e-005 244 3 M6115_1.02 TP73 CATGYCWGRRCHTGY 2.1e0000 2.9e-003 -5.85 0.0 216 486 289 539 0.44444 1.2e-005 242 3 M6139_1.02 AHR KCACGCRAH 3.3e-004 4.4e-007 -14.63 0.0 90 492 153 530 0.18293 1.8e-009 245 3 M6151_1.02 ARNT BYRCGTGC 4.2e0000 5.7e-003 -5.17 0.0 85 493 117 471 0.17241 2.3e-005 246 3 M6181_1.02 CREM CRVTGACGTCA 7.1e0000 9.6e-003 -4.65 0.0 276 490 317 486 0.56327 3.9e-005 244 3 M6186_1.02 DBP KVTTRCATAAB 1.5e-004 2.0e-007 -15.45 0.0 172 490 260 544 0.35102 8.0e-010 244 3 M6187_1.02 DDIT3 GGGGATTGCABBB 2.2e-020 3.0e-023 -51.87 0.0 132 488 274 576 0.27049 1.2e-025 243 3 M6189_1.02 DLX3 GMTAATTRSW 2.8e-001 3.7e-004 -7.89 0.0 131 491 184 508 0.26680 1.5e-006 245 3 M6208_1.02 ELK3 VMCHGGAARTSC 8.3e0000 1.1e-002 -4.49 0.0 247 489 312 528 0.50511 4.6e-005 244 3 M6270_1.02 NHLH1 RRGGMCGCAGCTGMKMCCCV 9.3e-006 1.2e-008 -18.20 0.0 65 481 95 358 0.13514 5.2e-011 240 3 M6272_1.02 HESX1 AKKYYAYKWGCCRSVT 4.3e0000 5.7e-003 -5.16 0.0 241 485 316 540 0.49691 2.4e-005 242 3 M6277_1.02 HLF SKRTTACRYAAYH 1.3e-003 1.8e-006 -13.22 0.0 168 488 206 431 0.34426 7.4e-009 243 3 M6278_1.02 HLTF KANKGCTGSMAM 5.5e-006 7.4e-009 -18.72 0.0 61 489 133 600 0.12474 3.0e-011 244 3 M6295_1.02 HOXB1 CCATCMATCW 9.9e0000 1.3e-002 -4.33 0.0 55 491 77 436 0.11202 5.4e-005 245 3 M6315_1.02 ISL1 SYTAATR 7.7e0000 1.0e-002 -4.57 0.0 82 494 124 531 0.16599 4.2e-005 246 3 M6316_1.02 TCF4 VCAGGTGYD 7.4e0000 9.9e-003 -4.62 0.0 74 492 113 526 0.15041 4.0e-005 245 3 M6330_1.02 MAFA BTGCTGACBMYGCARYHTYCV 1.1e-007 1.4e-010 -22.66 0.0 60 480 133 568 0.12500 6.0e-013 239 3 M6332_1.02 MAF KTGCTGAC 6.5e0000 8.7e-003 -4.75 0.0 59 493 106 599 0.11968 3.5e-005 246 3 M6333_1.02 MAFG MATGACT 5.9e0000 7.9e-003 -4.84 0.0 256 494 348 578 0.51822 3.2e-005 246 3 M6348_1.02 MTF1 MGKGCCGTGYGCAAADS 6.7e0000 9.0e-003 -4.71 0.0 78 484 95 397 0.16116 3.8e-005 241 3 M6350_1.02 MYB CMGTTRD 1.3e0000 1.8e-003 -6.32 0.0 72 494 118 545 0.14575 7.3e-006 246 3 M6352_1.02 MYCN CCACGTGS 2.6e-001 3.5e-004 -7.96 0.0 39 493 69 483 0.07911 1.4e-006 246 3 M6353_1.02 MYF6 GCAGSTG 1.8e-011 2.4e-014 -31.34 0.0 70 494 157 570 0.14170 9.9e-017 246 3 M6354_1.02 MYOD1 RACAGSTGS 3.1e-003 4.1e-006 -12.40 0.0 64 492 125 585 0.13008 1.7e-008 245 3 M6355_1.02 MYOG YRACAGCTGCWGC 7.4e-023 9.9e-026 -57.58 0.0 72 488 185 552 0.14754 4.1e-028 243 3 M6359_1.02 NFE2L1 NATGACD 8.3e0000 1.1e-002 -4.50 0.0 270 494 362 577 0.54656 4.6e-005 246 3 M6406_1.02 PAX2 RHTCAGTSAYGMGTGAYW 2.8e-002 3.7e-005 -10.21 0.0 85 483 142 534 0.17598 1.5e-007 241 3 M6410_1.02 PAX6 TSAWGCGTRAA 1.9e-003 2.6e-006 -12.87 0.0 74 490 134 551 0.15102 1.1e-008 244 3 M6411_1.02 PAX8 BTVAYTSRMGYRKR 1.2e0000 1.6e-003 -6.46 0.0 237 487 340 589 0.48665 6.4e-006 243 3 M6419_1.02 PKNOX1 HATCARTCAABYB 5.6e0000 7.5e-003 -4.89 0.0 152 488 217 551 0.31148 3.1e-005 243 3 M6423_1.02 POU2F1 ATTTGCATD 3.5e-002 4.6e-005 -9.98 0.0 86 492 148 567 0.17480 1.9e-007 245 3 M6425_1.02 POU3F1 HTTGCATWWSMATB 8.7e-001 1.2e-003 -6.75 0.0 129 487 189 536 0.26489 4.8e-006 243 3 M6508_1.02 TEAD3 GAHATTYYWGCYBYW 1.6e-001 2.1e-004 -8.45 0.0 12 486 36 573 0.02469 8.9e-007 242 3 M6513_1.02 TFAP4 RYCAGCTGYGG 1.9e-010 2.5e-013 -29.00 0.0 204 490 302 509 0.41633 1.0e-015 244 3 M6559_1.02 ZNF589 CCMASGGKWWYWRCCS 1.9e-001 2.6e-004 -8.27 0.0 131 485 206 571 0.27010 1.1e-006 242 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).