# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 RTGACGTCAYNV MEME-1 RTGACGTCAYNV 1.9e-171 2.5e-174 -399.72 0.0 97 489 438 594 0.19836 1.0e-176 244 1 RTGAYGTCAYDS MEME-2 RTGAYGTCAYDS 1.2e-127 1.6e-130 -298.87 0.0 85 489 343 518 0.17382 6.6e-133 244 1 STGMGTCAB MEME-3 STGMGTCAB 5.9e-015 7.9e-018 -39.38 0.0 144 492 105 164 0.29268 3.2e-020 245 1 GCGSGYCTTCGCCGACACCATAGAGGTGGGCCTTYSGCGDCGT MEME-4 GCGSGYCTTCGCCGACACCATAGAGGTGGGCCTTYSGCGDCGT 2.7e-001 3.7e-004 -7.91 0.0 104 458 9 9 0.22707 1.6e-006 228 1 TCATCAYCAWCACCAB MEME-9 TCATCAYCAWCACCAB 4.3e0000 5.7e-003 -5.17 0.0 85 485 36 106 0.17526 2.4e-005 242 2 ABGTCAY DREME-1 ACGTCAY 1.1e-127 1.5e-130 -298.93 0.0 112 494 361 477 0.22672 6.1e-133 246 2 RCGTCA DREME-2 GCGTCA 6.5e-106 8.7e-109 -248.82 0.0 129 495 353 466 0.26061 3.5e-111 247 2 CGGAAR DREME-3 CGGAAG 1.6e-005 2.1e-008 -17.69 0.0 147 495 135 282 0.29697 8.4e-011 247 2 RTGACTCA DREME-4 RTGACTCA 4.3e-003 5.8e-006 -12.06 0.0 239 493 103 144 0.48479 2.4e-008 246 3 M0189_1.02 (ID2)_(Mus_musculus)_(DBD_0.98) RCACGTGR 2.9e-004 3.9e-007 -14.76 0.0 97 493 153 495 0.19675 1.6e-009 246 3 M0199_1.02 (HES2)_(Mus_musculus)_(DBD_0.83) NNNNGRCACGTGM 8.7e0000 1.2e-002 -4.45 0.0 100 488 157 574 0.20492 4.8e-005 243 3 M0211_1.02 (MLXIP)_(Mus_musculus)_(DBD_0.82) BCACGTGK 9.6e-004 1.3e-006 -13.56 0.0 99 493 155 501 0.20081 5.2e-009 246 3 M0212_1.02 (TCFL5)_(Mus_musculus)_(DBD_1.00) NBCDCGHGVN 3.9e-001 5.3e-004 -7.55 0.0 57 491 83 428 0.11609 2.1e-006 245 3 M0300_1.02 (ATF2)_(Mus_musculus)_(DBD_1.00) NRTKACGTMA 1.2e-155 1.6e-158 -363.36 0.0 129 491 474 599 0.26273 6.4e-161 245 3 M0305_1.02 (CREB3L2)_(Mus_musculus)_(DBD_1.00) GCCACGTGD 1.2e-020 1.6e-023 -52.49 0.0 64 492 152 482 0.13008 6.5e-026 245 3 M0307_1.02 (ENSG00000250542)_(Mus_musculus)_(DBD_1.00) WWACGTWD 6.6e0000 8.9e-003 -4.73 0.0 101 493 129 456 0.20487 3.6e-005 246 3 M0424_1.02 (SNAI3)_(Mus_musculus)_(DBD_0.75) NNTGACAKNN 1.5e-023 2.0e-026 -59.15 0.0 73 491 198 599 0.14868 8.4e-029 245 3 M0607_1.02 KDM2B NCGNDNNNN 3.2e-004 4.2e-007 -14.67 0.0 106 492 59 130 0.21545 1.7e-009 245 3 M0608_1.02 MLL NNNRSCGNDN 2.4e-004 3.2e-007 -14.95 0.0 155 491 195 428 0.31568 1.3e-009 245 3 M0610_1.02 TET1 NNYRCGYWN 8.5e-006 1.1e-008 -18.29 0.0 94 492 148 464 0.19106 4.6e-011 245 3 M0714_1.02 (ENSG00000235187)_(Mus_musculus)_(DBD_1.00) NDBCGGAARY 7.9e0000 1.1e-002 -4.55 0.0 53 491 96 591 0.10794 4.3e-005 245 3 M1281_1.02 (NAIF1)_(Xenopus_tropicalis)_(DBD_0.71) NNTACGYHN 1.6e-020 2.1e-023 -52.21 0.0 116 492 214 468 0.23577 8.6e-026 245 3 M1432_1.02 NR2E1 NYTGACCTCD 3.1e-051 4.2e-054 -122.91 0.0 81 491 260 584 0.16497 1.7e-056 245 3 M1458_1.02 (RORB)_(Tetraodon_nigroviridis)_(DBD_1.00) NNTGACCTCN 6.7e-029 8.9e-032 -71.50 0.0 49 491 161 572 0.09980 3.6e-034 245 3 M1528_1.02 (RFX6)_(Mus_musculus)_(DBD_0.66) VCNTRGYWAC 3.9e0000 5.2e-003 -5.27 0.0 109 491 174 589 0.22200 2.1e-005 245 3 M1545_1.02 GMEB1 NNNRCGTNN 4.9e-096 6.6e-099 -226.07 0.0 100 492 336 535 0.20325 2.7e-101 245 3 M1917_1.02 USF1 GGTCACRTGRB 4.6e-006 6.2e-009 -18.91 0.0 96 490 156 483 0.19592 2.5e-011 244 3 M2065_1.02 ESR2 RGGKCANBSTGACCT 1.6e-003 2.1e-006 -13.06 0.0 196 486 282 537 0.40329 8.8e-009 242 3 M2268_1.02 CEBPB KATTGCAYMAY 1.4e-001 1.8e-004 -8.62 0.0 86 490 126 476 0.17551 7.4e-007 244 3 M2278_1.02 FOS DVTGASTCATB 2.2e-002 2.9e-005 -10.44 0.0 42 490 73 448 0.08571 1.2e-007 244 3 M2289_1.02 JUN DDRATGATGTMAT 5.7e-112 7.6e-115 -262.77 0.0 94 488 358 562 0.19262 3.1e-117 243 3 M2292_1.02 JUND DRTGASTCATS 6.0e-001 8.0e-004 -7.13 0.0 40 490 63 424 0.08163 3.3e-006 244 3 M2387_1.02 SREBF1 RTGGGGTGAB 6.7e-027 8.9e-030 -66.89 0.0 87 491 222 576 0.17719 3.6e-032 245 3 M2388_1.02 SREBF2 RTGGGGTGAY 1.9e-021 2.6e-024 -54.32 0.0 87 491 208 569 0.17719 1.1e-026 245 3 M4451_1.02 ATF3 GGTCACGTGRS 8.9e-069 1.2e-071 -163.31 0.0 88 490 283 534 0.17959 4.9e-074 244 3 M4462_1.02 GABPA VVCCGGAAGTG 2.9e-002 3.8e-005 -10.17 0.0 38 490 77 540 0.07755 1.6e-007 244 3 M4481_1.02 USF2 GGTCACGTGRSSSSV 7.7e-018 1.0e-020 -46.03 0.0 88 486 167 435 0.18107 4.2e-023 242 3 M4511_1.02 RXRA TGACCYYW 6.4e-003 8.6e-006 -11.66 0.0 139 493 228 592 0.28195 3.5e-008 246 3 M4526_1.02 SMARCC1 DSRVDGTGASTCABV 1.6e0000 2.2e-003 -6.13 0.0 158 486 202 482 0.32510 9.0e-006 242 3 M4553_1.02 BHLHE40 NGKCACGTGC 3.7e-005 5.0e-008 -16.82 0.0 101 491 163 501 0.20570 2.0e-010 245 3 M4565_1.02 FOSL2 VDGGATGASTCAYH 1.3e-003 1.7e-006 -13.27 0.0 45 487 79 435 0.09240 7.1e-009 243 3 M4619_1.02 FOSL1 BGGTGASTCAK 2.9e-001 3.9e-004 -7.86 0.0 60 490 87 429 0.12245 1.6e-006 244 3 M4623_1.02 JUNB NDRTGASTCATNYHY 1.9e-001 2.5e-004 -8.29 0.0 74 486 108 454 0.15226 1.0e-006 242 3 M4629_1.02 NFE2 VRTGACTCAGCANWWYB 7.3e0000 9.8e-003 -4.63 0.0 138 484 146 386 0.28512 4.1e-005 241 3 M4680_1.02 BACH1 GTCACGTG 1.8e-014 2.4e-017 -38.26 0.0 101 493 197 522 0.20487 9.8e-020 246 3 M4681_1.02 BACH2 TGCTGAGTCA 5.4e-001 7.2e-004 -7.24 0.0 147 491 169 417 0.29939 2.9e-006 245 3 M4930_1.02 (NPAS4)_(Drosophila_melanogaster)_(DBD_0.61) RADTCGTGACT 3.5e-003 4.7e-006 -12.26 0.0 158 490 191 422 0.32245 1.9e-008 244 3 M5234_1.02 (SIM1)_(Drosophila_melanogaster)_(DBD_0.89) GGTCACGTAC 7.5e-010 1.0e-012 -27.63 0.0 75 491 130 432 0.15275 4.1e-015 245 3 M5292_1.02 ATF4 GKATGAYGCAATM 4.3e-066 5.8e-069 -157.12 0.0 78 488 266 542 0.15984 2.4e-071 243 3 M5293_1.02 ATF7 NKATGACGTCATHN 7.6e-144 1.0e-146 -336.16 0.0 83 487 368 548 0.17043 4.2e-149 243 3 M5302_1.02 BATF3 TGATGACGTCATCA 6.8e-104 9.0e-107 -244.17 0.0 131 487 320 398 0.26899 3.7e-109 243 3 M5323_1.02 CREB3 KGRTGACGTCAYNV 1.3e-142 1.8e-145 -333.30 0.0 131 487 441 553 0.26899 7.3e-148 243 3 M5325_1.02 CREB3L1 TGRTGACGTGGCAB 7.3e-030 9.8e-033 -73.70 0.0 81 487 179 424 0.16632 4.0e-035 243 3 M5349_1.02 DUXA NTRAYBTAATCAN 2.6e-002 3.5e-005 -10.27 0.0 158 488 211 482 0.32377 1.4e-007 243 3 M5398_1.02 ERF ACCGGAAGTR 6.9e-002 9.2e-005 -9.30 0.0 65 491 112 529 0.13238 3.7e-007 245 3 M5420_1.02 ETV1 ACCGGAAGTD 7.6e-002 1.0e-004 -9.20 0.0 61 491 109 546 0.12424 4.1e-007 245 3 M5421_1.02 ETV2 AACCGGAAATR 2.1e0000 2.8e-003 -5.89 0.0 64 490 100 499 0.13061 1.1e-005 244 3 M5422_1.02 ETV3 ACCGGAAGTR 3.2e-002 4.3e-005 -10.06 0.0 111 491 175 544 0.22607 1.7e-007 245 3 M5427_1.02 EVX1 SNTAATYABB 9.0e0000 1.2e-002 -4.42 0.0 91 491 129 503 0.18534 4.9e-005 245 3 M5435_1.02 FOXB1 TCGCYGTGTCATTC 1.1e-002 1.4e-005 -11.17 0.0 47 487 80 445 0.09651 5.8e-008 243 3 M5493_1.02 GMEB2 KTRCGTAA 2.0e-072 2.7e-075 -171.69 0.0 89 493 293 547 0.18053 1.1e-077 246 3 M5509_1.02 HEY1 GRCACGTGBC 4.6e-003 6.2e-006 -11.99 0.0 97 491 135 438 0.19756 2.5e-008 245 3 M5581_1.02 IRX2 CDTGTCRTGTWN 7.4e-003 9.9e-006 -11.52 0.0 51 489 99 547 0.10429 4.1e-008 244 3 M5582_1.02 IRX5 SWTGTYRTGTWN 6.2e-002 8.2e-005 -9.40 0.0 117 489 183 547 0.23926 3.4e-007 244 3 M5587_1.02 JDP2 ATGASTCAT 1.4e-005 1.9e-008 -17.78 0.0 244 492 249 377 0.49593 7.8e-011 245 3 M5621_1.02 MEIS3 SCTGTCAH 5.0e-006 6.7e-009 -18.82 0.0 117 493 213 594 0.23732 2.7e-011 246 3 M5632_1.02 MLX RTCACGTGAT 1.5e-029 2.0e-032 -72.98 0.0 97 491 185 390 0.19756 8.3e-035 245 3 M5634_1.02 MNT RVCACGTGVH 3.0e-001 4.0e-004 -7.81 0.0 103 491 146 486 0.20978 1.7e-006 245 3 M5689_1.02 NRL DWWNTGCTGAC 5.7e-001 7.7e-004 -7.17 0.0 58 490 107 584 0.11837 3.1e-006 244 3 M5702_1.02 PAX1 DKCABTCAWGCGTGACG 6.6e-011 8.8e-014 -30.06 0.0 138 484 154 303 0.28512 3.7e-016 241 3 M5711_1.02 PAX9 KKCASTCAWGCGTGACS 6.6e-008 8.8e-011 -23.15 0.0 138 484 117 227 0.28512 3.7e-013 241 3 M5753_1.02 PROX1 YAAGACGYCTTA 3.2e-005 4.3e-008 -16.96 0.0 101 489 124 351 0.20654 1.8e-010 244 3 M5889_1.02 TBX21 GGTGTGAHWTCACACC 6.3e-009 8.4e-012 -25.50 0.0 119 485 133 299 0.24536 3.5e-014 242 3 M5932_1.02 TFEC VTCAYGTGAY 1.4e-005 1.9e-008 -17.79 0.0 105 491 178 532 0.21385 7.7e-011 245 3 M5958_1.02 ZBED1 YATGTCGCGAYAG 1.9e-006 2.5e-009 -19.80 0.0 78 488 61 161 0.15984 1.0e-011 243 3 M5998_1.02 (CREB5)_(Mus_musculus)_(DBD_1.00) DRTGACGTCATN 7.0e-154 9.3e-157 -359.27 0.0 133 489 460 564 0.27198 3.8e-159 244 3 M6139_1.02 AHR KCACGCRAH 2.0e-002 2.7e-005 -10.50 0.0 94 492 152 532 0.19106 1.1e-007 245 3 M6151_1.02 ARNT BYRCGTGC 1.9e-007 2.6e-010 -22.09 0.0 97 493 163 490 0.19675 1.0e-012 246 3 M6152_1.02 ATF1 VTGACGTCAV 2.6e-154 3.5e-157 -360.25 0.0 125 491 466 596 0.25458 1.4e-159 245 3 M6155_1.02 ATF6 GBGSTGACGTGG 2.2e-060 2.9e-063 -143.99 0.0 81 489 256 522 0.16564 1.2e-065 244 3 M6162_1.02 ARNTL GRGTCACGTGTYCM 2.0e-002 2.6e-005 -10.55 0.0 107 487 115 335 0.21971 1.1e-007 243 3 M6166_1.02 CDC5L RWTAYRTTAAMWCVC 1.1e-002 1.5e-005 -11.10 0.0 50 486 92 505 0.10288 6.3e-008 242 3 M6171_1.02 CEBPD RRTKDBGCAAT 2.7e-001 3.6e-004 -7.94 0.0 112 490 176 556 0.22857 1.5e-006 244 3 M6172_1.02 CEBPE VAKATTDCGHAA 1.4e-008 1.8e-011 -24.73 0.0 115 489 210 558 0.23517 7.5e-014 244 3 M6180_1.02 CREB1 RTGACGTMA 1.9e-171 2.6e-174 -399.71 0.0 134 492 496 599 0.27236 1.0e-176 245 3 M6181_1.02 CREM CRVTGACGTCA 1.9e-133 2.6e-136 -312.20 0.0 92 490 390 592 0.18776 1.1e-138 244 3 M6186_1.02 DBP BVTTRCATAAB 3.5e-012 4.7e-015 -33.00 0.0 132 490 231 523 0.26939 1.9e-017 244 3 M6197_1.02 E4F1 YGTKACGTC 4.8e-127 6.5e-130 -297.47 0.0 98 492 391 587 0.19919 2.6e-132 245 3 M6207_1.02 ELK1 RCCGGAAGT 4.0e0000 5.3e-003 -5.24 0.0 64 492 112 585 0.13008 2.2e-005 245 3 M6210_1.02 ENO1 YDSMCACRTGSYB 8.8e-001 1.2e-003 -6.74 0.0 102 488 162 561 0.20902 4.9e-006 243 3 M6213_1.02 ERG ACCGGAARTSM 9.3e-003 1.2e-005 -11.29 0.0 50 490 93 518 0.10204 5.1e-008 244 3 M6216_1.02 ESRRG TGACCTTGA 6.2e-005 8.2e-008 -16.31 0.0 122 492 205 561 0.24797 3.4e-010 245 3 M6224_1.02 ETV7 KCMHCAGGAAGTRACDY 6.9e-003 9.2e-006 -11.60 0.0 48 484 83 453 0.09917 3.8e-008 241 3 M6226_1.02 FEV CAGGAARTDA 5.2e0000 7.0e-003 -4.96 0.0 47 491 85 564 0.09572 2.9e-005 245 3 M6275_1.02 HIF1A SBSTACGTGCSB 1.1e-002 1.4e-005 -11.14 0.0 99 489 148 484 0.20245 5.9e-008 244 3 M6276_1.02 HINFP DMSNHMGCGGACGTTV 4.6e-003 6.2e-006 -12.00 0.0 173 485 196 399 0.35670 2.5e-008 242 3 M6277_1.02 HLF SKRTTACRYAAYC 4.8e-042 6.4e-045 -101.76 0.0 110 488 265 509 0.22541 2.6e-047 243 3 M6315_1.02 ISL1 SYTAATR 2.8e0000 3.8e-003 -5.57 0.0 26 494 51 518 0.05263 1.5e-005 246 3 M6331_1.02 MAFB WGCTGACDS 9.2e-009 1.2e-011 -25.12 0.0 90 492 185 596 0.18293 5.0e-014 245 3 M6332_1.02 MAF KTGCTGAC 3.8e0000 5.1e-003 -5.28 0.0 77 493 132 596 0.15619 2.1e-005 246 3 M6333_1.02 MAFG MATGACT 1.5e-068 1.9e-071 -162.82 0.0 88 494 302 597 0.17814 7.9e-074 246 3 M6345_1.02 MITF VKCACATGWY 5.5e0000 7.3e-003 -4.92 0.0 103 491 157 555 0.20978 3.0e-005 245 3 M6359_1.02 NFE2L1 NATGACD 6.5e-058 8.7e-061 -138.30 0.0 88 494 286 599 0.17814 3.5e-063 246 3 M6368_1.02 NFIL3 VKVMVTTACRTAAY 2.0e-037 2.7e-040 -91.12 0.0 83 487 214 493 0.17043 1.1e-042 243 3 M6406_1.02 PAX2 RHKCAGTSAYGMGTGAYW 4.7e-009 6.3e-012 -25.80 0.0 121 483 212 528 0.25052 2.6e-014 241 3 M6443_1.02 RARA TGACCTB 1.6e-036 2.1e-039 -89.06 0.0 84 494 242 598 0.17004 8.5e-042 246 3 M6445_1.02 RARB BBBBTGACCTS 1.1e-014 1.5e-017 -38.75 0.0 54 490 143 585 0.11020 6.1e-020 244 3 M6454_1.02 RORA TGACCTAVWTWH 9.9e-002 1.3e-004 -8.93 0.0 39 489 67 448 0.07975 5.4e-007 244 3 M6461_1.02 RXRB YSTGACCTSA 1.8e-042 2.3e-045 -102.77 0.0 85 491 255 595 0.17312 9.6e-048 245 3 M6462_1.02 RXRG DTGACCTTTGACC 3.2e-002 4.3e-005 -10.05 0.0 90 488 108 367 0.18443 1.8e-007 243 3 M6510_1.02 TEF TGTTTATRTAAMTK 4.0e-018 5.4e-021 -46.67 0.0 113 487 235 555 0.23203 2.2e-023 243 3 M6518_1.02 TFEB RGTCACGTG 3.7e-024 5.0e-027 -60.56 0.0 76 492 154 399 0.15447 2.0e-029 245 3 M6519_1.02 TGIF1 MWGSTGACACCTSMCA 8.5e-007 1.1e-009 -20.60 0.0 59 485 131 589 0.12165 4.7e-012 242 3 M6521_1.02 THRA STGACCTSAV 1.6e-022 2.1e-025 -56.81 0.0 87 491 216 588 0.17719 8.7e-028 245 3 M6523_1.02 THRB TGACCTSABSTSRSSYC 3.1e-012 4.2e-015 -33.11 0.0 100 484 204 565 0.20661 1.7e-017 241 3 M6536_1.02 XBP1 GACGTGKCMHWW 1.3e-008 1.8e-011 -24.75 0.0 57 489 99 394 0.11656 7.3e-014 244 3 M6540_1.02 ZBTB4 CAATRGYGDTKGYGR 3.6e0000 4.8e-003 -5.33 0.0 92 486 134 504 0.18930 2.0e-005 242 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).