# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 RSTTCCGGB MEME-1 RSTTCCGGB 2.8e-083 3.8e-086 -196.69 0.0 172 492 446 594 0.34959 1.5e-088 245 1 GGGCATTCTGGGAADTGTAGT MEME-2 GGGCATTCTGGGAADTGTAGT 9.8e0000 1.3e-002 -4.33 0.0 274 480 62 79 0.57083 5.6e-005 239 2 CGGAAVY DREME-1 CGGAASY 5.8e-074 7.9e-077 -175.24 0.0 162 494 389 535 0.32794 3.2e-079 246 2 CMGGAA DREME-2 CMGGAA 8.8e-033 1.2e-035 -80.41 0.0 129 495 282 540 0.26061 4.8e-038 247 3 M0396_1.02 (OSR2)_(Mus_musculus)_(DBD_1.00) HMCRGTAGCN 1.8e-001 2.4e-004 -8.35 0.0 137 491 220 596 0.27902 9.7e-007 245 3 M0398_1.02 (ZSCAN10)_(Mus_musculus)_(DBD_0.82) NGGRAGTGCNN 1.8e-005 2.4e-008 -17.54 0.0 170 490 279 587 0.34694 9.9e-011 244 3 M0431_1.02 (OSR1)_(Mus_musculus)_(DBD_1.00) MCRGTAGCN 7.1e-002 9.6e-005 -9.25 0.0 100 492 173 599 0.20325 3.9e-007 245 3 M0608_1.02 MLL NNNRSCGNDN 6.9e-005 9.4e-008 -16.18 0.0 135 491 209 523 0.27495 3.8e-010 245 3 M0609_1.02 DNMT1 NNCCGCNNNN 3.0e-006 4.1e-009 -19.31 0.0 147 491 234 537 0.29939 1.7e-011 245 3 M0714_1.02 (ENSG00000235187)_(Mus_musculus)_(DBD_1.00) NDBCGGAARY 1.4e-049 2.0e-052 -119.06 0.0 137 491 350 600 0.27902 8.0e-055 245 3 M2275_1.02 ELF1 RRAVCMGGAAGTG 1.4e-037 1.9e-040 -91.45 0.0 148 488 342 595 0.30328 7.9e-043 243 3 M2277_1.02 FLI1 RCAGGAAGTGR 1.6e-039 2.2e-042 -95.91 0.0 126 490 315 597 0.25714 9.1e-045 244 3 M2390_1.02 EHF SAGGAAGK 4.8e-004 6.5e-007 -14.24 0.0 125 493 210 575 0.25355 2.7e-009 246 3 M4453_1.02 BCL11A ADGRGGAASTGARAV 3.4e0000 4.5e-003 -5.39 0.0 100 486 159 572 0.20576 1.9e-005 242 3 M4462_1.02 GABPA VVCCGGAAGTG 2.6e-068 3.6e-071 -162.21 0.0 160 490 412 598 0.32653 1.5e-073 244 3 M4522_1.02 ELK4 CCGGAAGYGS 2.9e-057 3.9e-060 -136.79 0.0 157 491 391 599 0.31976 1.6e-062 245 3 M4537_1.02 E2F4 SGCGGGAARWTBVRR 1.4e-001 1.9e-004 -8.59 0.0 226 486 328 579 0.46502 7.7e-007 242 3 M5377_1.02 ELF4 AACCCGGAAGTR 5.5e-041 7.4e-044 -99.31 0.0 193 489 391 565 0.39468 3.0e-046 244 3 M5398_1.02 ERF ACCGGAAGTR 5.1e-058 7.0e-061 -138.52 0.0 127 491 348 595 0.25866 2.8e-063 245 3 M5420_1.02 ETV1 ACCGGAAGTD 8.2e-057 1.1e-059 -135.75 0.0 135 491 359 597 0.27495 4.5e-062 245 3 M5421_1.02 ETV2 AACCGGAAATR 1.8e-051 2.4e-054 -123.47 0.0 152 490 364 576 0.31020 9.8e-057 244 3 M5422_1.02 ETV3 ACCGGAAGTR 9.4e-050 1.3e-052 -119.50 0.0 121 491 323 590 0.24644 5.2e-055 245 3 M5425_1.02 ETV6 CCGGAASCGGAAGYR 4.2e-044 5.7e-047 -106.49 0.0 156 486 339 535 0.32099 2.3e-049 242 3 M5497_1.02 GRHL1 AACCGGTYTAACCGGTT 2.6e-002 3.6e-005 -10.24 0.0 32 484 48 323 0.06612 1.5e-007 241 3 M5857_1.02 SPDEF AMCCGGATGTW 4.0e-031 5.4e-034 -76.61 0.0 114 490 259 537 0.23265 2.2e-036 244 3 M5865_1.02 SPIC NAAAAGVGGAAGTA 1.5e-001 2.1e-004 -8.49 0.0 101 487 165 562 0.20739 8.5e-007 243 3 M6119_1.02 SPI1 RAAAAGAGGAAGTGV 2.4e-002 3.3e-005 -10.33 0.0 142 486 214 540 0.29218 1.3e-007 242 3 M6192_1.02 E2F3 SSCGCSAAAC 9.5e-001 1.3e-003 -6.66 0.0 421 491 509 553 0.85743 5.2e-006 245 3 M6194_1.02 E2F5 SGCGCSAAAH 1.5e0000 2.0e-003 -6.23 0.0 31 491 59 513 0.06314 8.1e-006 245 3 M6204_1.02 ELF2 TDNCAGGAAGTRRVT 1.6e-026 2.1e-029 -66.03 0.0 126 486 286 589 0.25926 8.7e-032 242 3 M6205_1.02 ELF3 GGSAAACAGGAARY 2.9e-003 3.9e-006 -12.45 0.0 147 487 232 563 0.30185 1.6e-008 243 3 M6206_1.02 ELF5 AHMAGGAWRTW 1.7e-009 2.3e-012 -26.78 0.0 134 490 247 587 0.27347 9.6e-015 244 3 M6207_1.02 ELK1 RCCGGAAGT 3.0e-063 4.1e-066 -150.56 0.0 160 492 404 599 0.32520 1.7e-068 245 3 M6208_1.02 ELK3 VMCHGGAARTSC 1.0e-029 1.4e-032 -73.34 0.0 141 489 311 585 0.28834 5.8e-035 244 3 M6213_1.02 ERG ACCGGAARTSM 2.2e-047 2.9e-050 -114.06 0.0 180 490 396 583 0.36735 1.2e-052 244 3 M6221_1.02 ETS2 VMVGGAAGTKS 4.0e-039 5.4e-042 -95.03 0.0 142 490 338 600 0.28980 2.2e-044 244 3 M6222_1.02 ETV4 SAGGAAGY 9.0e-031 1.2e-033 -75.78 0.0 143 493 321 600 0.29006 5.0e-036 246 3 M6223_1.02 ETV5 GHCAGGAAGWWAY 7.7e-005 1.0e-007 -16.07 0.0 136 488 235 593 0.27869 4.3e-010 243 3 M6224_1.02 ETV7 KCMHCAGGAAGTRACDY 1.5e-013 2.1e-016 -36.12 0.0 142 484 244 509 0.29339 8.5e-019 241 3 M6226_1.02 FEV CAGGAARTDV 3.0e-022 4.0e-025 -56.17 0.0 119 491 264 590 0.24236 1.6e-027 245 3 M6276_1.02 HINFP DMSNHMGCGGACGTTV 4.4e-002 5.9e-005 -9.73 0.0 141 485 196 493 0.29072 2.5e-007 242 3 M6337_1.02 MBD2 SSGKCCGGMGR 7.4e-008 1.0e-010 -23.02 0.0 102 490 193 569 0.20816 4.1e-013 244 3 M6339_1.02 MECP2 YYCCGGS 3.5e-036 4.7e-039 -88.26 0.0 118 494 283 565 0.23887 1.9e-041 246 3 M6361_1.02 NFATC1 AWGGAAWTTTCCD 2.7e-002 3.6e-005 -10.23 0.0 74 488 110 448 0.15164 1.5e-007 243 3 M6485_1.02 SPIB ARAAASMGGAAS 1.7e-003 2.3e-006 -12.97 0.0 145 489 235 576 0.29652 9.6e-009 244 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).