# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 AASATGGCGGCSSCS MEME-1 AASATGGCGGCSSCS 2.4e-099 3.3e-102 -233.67 0.0 142 486 410 555 0.29218 1.4e-104 242 1 RYCRCCRCCACCAYCA MEME-3 RYCRCCRCCACCAYCA 1.1e-008 1.5e-011 -24.91 0.0 109 485 132 322 0.22474 6.3e-014 242 2 ATGGCNG DREME-1 ATGGCGG 1.7e-079 2.2e-082 -188.01 0.0 144 494 347 480 0.29150 9.1e-085 246 2 AAVATGG DREME-2 AAGATGG 3.1e-049 4.2e-052 -118.29 0.0 114 494 225 369 0.23077 1.7e-054 246 2 MCGGAA DREME-4 CCGGAA 5.7e-001 7.7e-004 -7.17 0.0 357 495 295 358 0.72121 3.1e-006 247 2 CCGCCDCC DREME-5 CCGCCDCC 2.8e0000 3.7e-003 -5.59 0.0 411 493 255 277 0.83367 1.5e-005 246 3 M0195_1.02 (TCF23)_(Mus_musculus)_(DBD_0.60) DMCAKMTGKH 7.0e0000 9.4e-003 -4.67 0.0 151 491 214 552 0.30754 3.9e-005 245 3 M0217_1.02 (NEUROG1)_(Mus_musculus)_(DBD_1.00) DCCATATGKB 2.1e0000 2.8e-003 -5.87 0.0 83 491 133 553 0.16904 1.2e-005 245 3 M0305_1.02 (CREB3L2)_(Mus_musculus)_(DBD_1.00) GCCACGTGD 4.1e0000 5.5e-003 -5.21 0.0 308 492 309 429 0.62602 2.2e-005 245 3 M0609_1.02 DNMT1 NNCCGCNNNN 4.9e-001 6.6e-004 -7.32 0.0 269 491 329 507 0.54786 2.7e-006 245 3 M1919_1.02 YY1 CAARATGGCBGC 4.2e-069 5.6e-072 -164.06 0.0 113 489 339 579 0.23108 2.3e-074 244 3 M2264_1.02 (ATOH1)_(Mus_musculus)_(DBD_1.00) RCCAKCTG 5.7e-006 7.6e-009 -18.69 0.0 105 493 191 575 0.21298 3.1e-011 246 3 M2277_1.02 FLI1 RCAGGAAGTGR 1.7e0000 2.3e-003 -6.08 0.0 196 490 283 579 0.40000 9.4e-006 244 3 M2289_1.02 JUN DDRATGATGTCAT 1.8e0000 2.5e-003 -6.01 0.0 76 488 96 400 0.15574 1.0e-005 243 3 M4427_1.02 CTCF NYGGCCASCAGRKGGCRSYVB 1.2e0000 1.7e-003 -6.40 0.0 406 480 458 502 0.84583 7.0e-006 239 3 M4462_1.02 GABPA VVCCGGAAGTG 3.0e-002 4.0e-005 -10.13 0.0 246 490 347 569 0.50204 1.6e-007 244 3 M4522_1.02 ELK4 CCGGAAGYGS 4.4e-001 5.9e-004 -7.43 0.0 253 491 352 577 0.51527 2.4e-006 245 3 M4636_1.02 THAP1 YTGCCCDBANYMAAGATGGCG 1.1e-021 1.5e-024 -54.89 0.0 124 480 201 392 0.25833 6.1e-027 239 3 M5292_1.02 ATF4 GKATGAYGCAATM 3.8e0000 5.1e-003 -5.28 0.0 200 488 200 389 0.40984 2.1e-005 243 3 M5293_1.02 ATF7 BKATGACGTCATHN 3.9e-001 5.2e-004 -7.56 0.0 77 487 67 241 0.15811 2.1e-006 243 3 M5302_1.02 BATF3 TGATGACGTCATCA 3.2e0000 4.4e-003 -5.43 0.0 99 487 47 128 0.20329 1.8e-005 243 3 M5323_1.02 CREB3 KGRTGACGTCAYNV 2.2e0000 2.9e-003 -5.83 0.0 77 487 71 276 0.15811 1.2e-005 243 3 M5377_1.02 ELF4 AACCCGGAAGTR 2.8e-002 3.8e-005 -10.17 0.0 235 489 300 504 0.48057 1.6e-007 244 3 M5422_1.02 ETV3 ACCGGAAGTR 3.8e0000 5.1e-003 -5.28 0.0 255 491 337 555 0.51935 2.1e-005 245 3 M5493_1.02 GMEB2 KTRCGTAA 5.8e0000 7.8e-003 -4.85 0.0 279 493 331 506 0.56592 3.2e-005 246 3 M5652_1.02 NEUROD2 RMCATATGBY 1.4e-002 1.9e-005 -10.89 0.0 143 491 187 460 0.29124 7.6e-008 245 3 M5777_1.02 RFX4 NGTWRCCATGGYWACS 8.4e0000 1.1e-002 -4.48 0.0 87 485 90 337 0.17938 4.7e-005 242 3 M5955_1.02 YY2 WAATGGCGGHY 9.0e-069 1.2e-071 -163.29 0.0 144 490 388 591 0.29388 5.0e-074 244 3 M5998_1.02 (CREB5)_(Mus_musculus)_(DBD_1.00) DRTGACGTCATN 6.1e-003 8.2e-006 -11.71 0.0 101 489 100 289 0.20654 3.4e-008 244 3 M6151_1.02 ARNT BYRCGTGC 5.5e0000 7.4e-003 -4.91 0.0 317 493 365 501 0.64300 3.0e-005 246 3 M6197_1.02 E4F1 YGTKACGTC 8.9e-001 1.2e-003 -6.73 0.0 238 492 285 487 0.48374 4.9e-006 245 3 M6208_1.02 ELK3 VMCHGGAARTSC 6.1e0000 8.2e-003 -4.80 0.0 157 489 222 550 0.32106 3.4e-005 244 3 M6213_1.02 ERG ACCGGAARTSM 6.9e0000 9.2e-003 -4.68 0.0 246 490 318 541 0.50204 3.8e-005 244 3 M6540_1.02 ZBTB4 CAATRGCGDTKGYGR 2.3e-001 3.2e-004 -8.06 0.0 114 486 177 545 0.23457 1.3e-006 242 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).