# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 GGHGCTGTCCATGGTGCTG MEME-1 GGHGCTGTCCATGGTGCTG 5.5e-1305 7.3e-1308 -3009.79 0.0 56 482 1829 2184 0.11618 3.1e-1310 240 1 ATAAATAAATAAATAAATAAATAAATAAATAAATAAATAAATAA MEME-2 ATAAATAAATAAATAAATAAATAAATAAATAAATAAATAAATAA 4.7e-087 6.4e-090 -205.38 0.0 25 457 86 100 0.05470 2.8e-092 228 1 DGSTGGACAGCKCCM MEME-3 DGSTGGACAGCKCCM 6.3e-1229 8.5e-1232 -2834.65 0.0 52 486 1889 2551 0.10700 3.5e-1234 242 2 CTRTCC DREME-1 CTGTCC 4.8e-879 6.4e-882 -2029.02 0.0 53 495 1609 2540 0.10707 2.6e-884 247 2 GGTVCTGR DREME-2 GGTGCTGA 3.2e-664 4.3e-667 -1534.37 0.0 69 493 1164 1503 0.13996 1.7e-669 246 2 GTKCTGAW DREME-3 GTKCTGAA 6.6e-387 8.9e-390 -895.82 0.0 71 493 734 989 0.14402 3.6e-392 246 2 GCTCTCCR DREME-4 GCTCTCCA 1.8e-077 2.4e-080 -183.32 0.0 41 493 164 343 0.08316 9.9e-083 246 2 AGYACCWT DREME-5 AGCACCWT 2.2e-213 2.9e-216 -496.30 0.0 67 493 408 568 0.13590 1.2e-218 246 2 AATAAATA DREME-6 AATAAATA 9.8e-025 1.3e-027 -61.90 0.0 41 493 85 255 0.08316 5.3e-030 246 2 ATGGTR DREME-8 ATGGTR 5.5e-060 7.4e-063 -143.05 0.0 41 495 310 1289 0.08283 3.0e-065 247 3 M0085_1.02 (TFAP2E)_(Mus_musculus)_(DBD_0.99) THGCCYSVGG 1.6e-003 2.1e-006 -13.07 0.0 119 491 822 2846 0.24236 8.6e-009 245 3 M0178_1.02 (ASCL2)_(Mus_musculus)_(DBD_0.98) NVCAGCTGBN 4.1e-007 5.5e-010 -21.32 0.0 51 491 419 2880 0.10387 2.2e-012 245 3 M0198_1.02 (SOHLH2)_(Mus_musculus)_(DBD_0.84) NRYNCGTGCN 2.6e-034 3.5e-037 -83.94 0.0 43 491 451 2699 0.08758 1.4e-039 245 3 M0216_1.02 (NHLH2)_(Mus_musculus)_(DBD_1.00) NGCAGCTGYN 1.2e-011 1.6e-014 -31.75 0.0 59 491 509 2946 0.12016 6.6e-017 245 3 M0396_1.02 (OSR2)_(Mus_musculus)_(DBD_1.00) WACRGTAGCN 8.0e-003 1.1e-005 -11.45 0.0 145 491 1017 2985 0.29532 4.4e-008 245 3 M0404_1.02 (ZNF202)_(Mus_musculus)_(DBD_0.87) NNNKGGGGSV 4.3e0000 5.8e-003 -5.15 0.0 439 491 2692 2937 0.89409 2.4e-005 245 3 M0405_1.02 (KLF7)_(Mus_musculus)_(DBD_1.00) DGGGCGKGGY 4.9e-001 6.5e-004 -7.33 0.0 141 491 945 2900 0.28717 2.7e-006 245 3 M0413_1.02 (ZBTB1)_(Mus_musculus)_(DBD_0.99) NDTGCGKGDN 8.3e-012 1.1e-014 -32.13 0.0 73 491 545 2595 0.14868 4.5e-017 245 3 M0424_1.02 (SNAI3)_(Mus_musculus)_(DBD_0.75) NNTGACAKNN 1.5e-012 2.0e-015 -33.83 0.0 51 491 462 2991 0.10387 8.3e-018 245 3 M0431_1.02 (OSR1)_(Mus_musculus)_(DBD_1.00) MCRGTAGCN 1.6e-001 2.1e-004 -8.47 0.0 126 492 884 2995 0.25610 8.6e-007 245 3 M0432_1.02 (ZFP161)_(Mus_musculus)_(DBD_1.00) NNCGYGCHH 1.3e0000 1.7e-003 -6.35 0.0 42 492 181 1531 0.08537 7.1e-006 245 3 M0442_1.02 (ZBTB3)_(Mus_musculus)_(DBD_1.00) NNTGCAGYG 2.3e0000 3.1e-003 -5.77 0.0 190 492 1270 2996 0.38618 1.3e-005 245 3 M0603_1.02 CGBP NNNBCGK 1.0e-020 1.4e-023 -52.66 0.0 116 494 549 1553 0.23482 5.5e-026 246 3 M0609_1.02 DNMT1 NNCCGMNNNN 6.5e-025 8.7e-028 -62.31 0.0 105 491 687 2150 0.21385 3.5e-030 245 3 M1359_1.02 (MYPOP)_(Mus_musculus)_(DBD_0.97) NWTTGCGCCR 2.1e-001 2.8e-004 -8.18 0.0 77 491 430 2206 0.15682 1.1e-006 245 3 M1418_1.02 C11orf9 TGGTACCA 1.4e0000 1.9e-003 -6.28 0.0 3 493 35 2462 0.00609 7.6e-006 246 3 M1581_1.02 (CIC)_(Mus_musculus)_(DBD_1.00) NNTGCTGACW 6.2e-151 8.3e-154 -352.48 0.0 71 491 1002 2941 0.14460 3.4e-156 245 3 M1838_1.02 TFAP2A NHYDGCCYSAGGGCA 1.9e-003 2.5e-006 -12.90 0.0 118 486 776 2674 0.24280 1.0e-008 242 3 M1890_1.02 NFYA AGVSYKCTGATTGGTBSR 4.4e-001 5.9e-004 -7.43 0.0 39 483 217 1965 0.08075 2.5e-006 241 3 M1950_1.02 ZNF354C GTGGAK 1.5e-002 2.1e-005 -10.79 0.0 49 495 379 2936 0.09899 8.3e-008 247 3 M1968_1.02 EBF1 TCCCWGGGGRV 4.0e-007 5.4e-010 -21.35 0.0 104 490 756 2830 0.21224 2.2e-012 244 3 M2264_1.02 (ATOH1)_(Mus_musculus)_(DBD_1.00) RCCAKCTG 1.8e-002 2.4e-005 -10.63 0.0 291 493 1814 2843 0.59026 9.8e-008 246 3 M2286_1.02 HNF4G TGRMCTTTGNHCYYN 1.6e0000 2.1e-003 -6.15 0.0 60 486 433 2873 0.12346 8.8e-006 242 3 M2296_1.02 MAFK MWDASTCAGCAWWWW 4.4e-027 5.9e-030 -67.31 0.0 54 486 513 2722 0.11111 2.4e-032 242 3 M2299_1.02 (MYF5)_(Mus_musculus)_(DBD_0.90) NRNRRCAGCTGSN 7.7e-041 1.0e-043 -98.98 0.0 56 488 599 2891 0.11475 4.3e-046 243 3 M2305_1.02 NRF1 YGCGCABGCGC 1.4e-002 1.8e-005 -10.91 0.0 124 490 535 1730 0.25306 7.5e-008 244 3 M4427_1.02 CTCF NYGGCCASCAGRKGGCRSYVB 1.2e-010 1.6e-013 -29.43 0.0 226 480 1243 2238 0.47083 6.9e-016 239 3 M4444_1.02 RELA DGGGRMTTTCCMVN 1.9e-022 2.5e-025 -56.63 0.0 47 487 425 2570 0.09651 1.0e-027 243 3 M4462_1.02 GABPA VVCCGGAAGTG 2.4e-001 3.3e-004 -8.02 0.0 248 490 1410 2551 0.50612 1.3e-006 244 3 M4469_1.02 REST TCCRTGGTGCTGAA 6.3e-925 8.5e-928 -2134.66 0.0 65 487 1869 2781 0.13347 3.5e-930 243 3 M4471_1.02 PAX5 BCAGYSRAGCGTGAC 2.8e0000 3.8e-003 -5.57 0.0 148 486 922 2695 0.30453 1.6e-005 242 3 M4479_1.02 TCF12 VSAGCAGSTGB 5.8e-019 7.8e-022 -48.60 0.0 82 490 694 2876 0.16735 3.2e-024 244 3 M4522_1.02 ELK4 CCGGAAGYGS 5.6e-002 7.5e-005 -9.49 0.0 269 491 1647 2767 0.54786 3.1e-007 245 3 M4525_1.02 TFAP2C NGCCYSAGGSCANDB 1.7e-007 2.3e-010 -22.21 0.0 128 486 857 2634 0.26337 9.4e-013 242 3 M4536_1.02 E2F1 VRRVRGVGCGCGCRS 2.6e-011 3.5e-014 -30.98 0.0 100 486 619 2220 0.20576 1.5e-016 242 3 M4569_1.02 HSF1 GTCSYGGGTTCGADTCCC 1.6e-004 2.1e-007 -15.36 0.0 55 483 186 1045 0.11387 8.8e-010 241 3 M4572_1.02 MAFF TGCTGACTCAGCAWW 4.8e-001 6.4e-004 -7.35 0.0 82 486 433 2091 0.16872 2.7e-006 242 3 M4612_1.02 CTCFL CCRSCAGGGGGCGCY 8.5e-017 1.1e-019 -43.62 0.0 92 486 589 2145 0.18930 4.7e-022 242 3 M4640_1.02 ZBTB7A GGGSRRGGGKCBSNG 4.4e-001 5.9e-004 -7.43 0.0 154 486 953 2658 0.31687 2.4e-006 242 3 M4681_1.02 BACH2 TGCTGAGTCA 4.5e-002 6.1e-005 -9.71 0.0 53 491 320 2246 0.10794 2.5e-007 245 3 M4698_1.02 HNF4A BTGRMCTTTGVMCYB 1.2e-025 1.6e-028 -64.02 0.0 64 486 601 2864 0.13169 6.5e-031 242 3 M5335_1.02 CUX2 ATCGATAHNDTTATYGAT 2.8e-006 3.7e-009 -19.42 0.0 25 483 74 603 0.05176 1.5e-011 241 3 M5430_1.02 FIGLA WMCACCTGKW 9.9e-001 1.3e-003 -6.62 0.0 215 491 1397 2919 0.43788 5.4e-006 245 3 M5571_1.02 ID4 DVCAGGTGYN 2.6e-009 3.5e-012 -26.38 0.0 41 491 363 2892 0.08350 1.4e-014 245 3 M5621_1.02 MEIS3 SCTGTCAH 6.9e-049 9.3e-052 -117.50 0.0 51 493 592 2965 0.10345 3.8e-054 246 3 M5627_1.02 MESP1 NVCAGGTGYD 3.5e-012 4.7e-015 -32.98 0.0 41 491 383 2954 0.08350 1.9e-017 245 3 M5636_1.02 MSC AACAGCTGTT 6.4e-024 8.6e-027 -60.02 0.0 55 491 468 2476 0.11202 3.5e-029 245 3 M5664_1.02 NFIX TTGGCANNNNGCCAR 1.0e-006 1.4e-009 -20.39 0.0 78 486 487 2263 0.16049 5.7e-012 242 3 M5689_1.02 NRL DWWNTGCTGAC 8.8e-057 1.2e-059 -135.68 0.0 64 490 724 2977 0.13061 4.9e-062 244 3 M5722_1.02 PKNOX2 TGACACCTGTCA 1.8e-010 2.5e-013 -29.02 0.0 51 489 241 1372 0.10429 1.0e-015 244 3 M5934_1.02 TGIF2 TGACASCTGTCA 2.2e-013 3.0e-016 -35.75 0.0 51 489 287 1627 0.10429 1.2e-018 244 3 M5935_1.02 TGIF2LX TGACASCTGTCA 8.4e-015 1.1e-017 -39.03 0.0 51 489 258 1385 0.10429 4.6e-020 244 3 M5962_1.02 ZBTB7C NTYGGTGGTCGY 4.3e-003 5.8e-006 -12.05 0.0 61 489 446 2781 0.12474 2.4e-008 244 3 M5965_1.02 ZIC4 DCDCMGCRGGGGGYC 2.5e-001 3.3e-004 -8.01 0.0 216 486 1184 2404 0.44444 1.4e-006 242 3 M6131_1.02 (TFCP2L1)_(Mus_musculus)_(DBD_0.95) CYRGYTYHRDCYRGYTYNRDC 5.8e-003 7.8e-006 -11.76 0.0 158 480 1020 2692 0.32917 3.3e-008 239 3 M6144_1.02 TFAP2B BCCCBCRGGC 4.1e-009 5.5e-012 -25.93 0.0 169 491 1163 2818 0.34420 2.2e-014 245 3 M6155_1.02 ATF6 GKGSTGACGTGG 6.0e-001 8.1e-004 -7.12 0.0 63 489 318 1934 0.12883 3.3e-006 244 3 M6161_1.02 BHLHE41 WSVRKSYCACGTGMHGRRRV 2.6e-046 3.5e-049 -111.58 0.0 59 481 594 2586 0.12266 1.4e-051 240 3 M6176_1.02 NR2F1 TGACCTTTGVMC 2.8e-006 3.8e-009 -19.39 0.0 55 489 451 2942 0.11247 1.6e-011 244 3 M6185_1.02 CXXC1 CGKTGKY 3.4e-028 4.5e-031 -69.87 0.0 56 494 550 2895 0.11336 1.8e-033 246 3 M6192_1.02 E2F3 SSCGCSAAAC 1.6e0000 2.2e-003 -6.14 0.0 81 491 383 1885 0.16497 8.8e-006 245 3 M6215_1.02 ESRRB TGACCTTGR 1.3e-028 1.8e-031 -70.80 0.0 52 492 522 2882 0.10569 7.3e-034 245 3 M6270_1.02 NHLH1 RRGGMCGCAGCTGMKMCCCV 5.3e-006 7.2e-009 -18.75 0.0 57 481 327 1929 0.11850 3.0e-011 240 3 M6271_1.02 HES1 KGKCKCGTGBCKB 3.6e-004 4.8e-007 -14.55 0.0 208 488 1365 2836 0.42623 2.0e-009 243 3 M6306_1.02 INSM1 TGTMAGGGGGCR 1.1e0000 1.4e-003 -6.54 0.0 273 489 1349 2233 0.55828 5.9e-006 244 3 M6316_1.02 TCF4 VCAGGTGCD 6.2e-017 8.3e-020 -43.94 0.0 42 492 387 2746 0.08537 3.4e-022 245 3 M6325_1.02 KLF6 GGGGGCKG 5.5e-001 7.3e-004 -7.22 0.0 143 493 946 2877 0.29006 3.0e-006 246 3 M6330_1.02 MAFA STGCTGACBMYGCARYHTYCV 5.3e-049 7.2e-052 -117.77 0.0 64 480 701 2923 0.13333 3.0e-054 239 3 M6331_1.02 MAFB WGCTGACDS 1.2e-072 1.6e-075 -172.25 0.0 64 492 770 2989 0.13008 6.3e-078 245 3 M6332_1.02 MAF KTGCTGAC 1.8e-227 2.4e-230 -528.72 0.0 61 493 1064 2994 0.12373 9.8e-233 246 3 M6337_1.02 MBD2 SSGKCCGGMGR 4.6e-008 6.2e-011 -23.51 0.0 114 490 631 2091 0.23265 2.5e-013 244 3 M6339_1.02 MECP2 YYCCGGS 4.6e-009 6.2e-012 -25.81 0.0 74 494 543 2657 0.14980 2.5e-014 246 3 M6344_1.02 MEIS2 KGACAVCTGTCAA 8.9e-005 1.2e-007 -15.93 0.0 42 488 291 2349 0.08607 4.9e-010 243 3 M6346_1.02 MLXIPL VCACGVSGKKGBCMCRTGC 7.9e0000 1.1e-002 -4.55 0.0 142 482 646 1923 0.29461 4.4e-005 240 3 M6348_1.02 MTF1 MGKGCCGTGYGCAAARS 8.1e-002 1.1e-004 -9.12 0.0 140 484 654 1918 0.28926 4.5e-007 241 3 M6353_1.02 MYF6 GCAGSTG 5.4e-020 7.2e-023 -50.98 0.0 50 494 473 2884 0.10121 2.9e-025 246 3 M6354_1.02 MYOD1 RACAGSTGS 5.0e-028 6.7e-031 -69.47 0.0 48 492 500 2962 0.09756 2.8e-033 245 3 M6355_1.02 MYOG YRACAGCTGCWGC 3.0e-029 4.0e-032 -72.29 0.0 56 488 542 2778 0.11475 1.7e-034 243 3 M6358_1.02 NEUROD1 SGGCAGRTGKSC 1.3e-030 1.7e-033 -75.46 0.0 59 489 582 2870 0.12065 7.0e-036 244 3 M6360_1.02 NFE2L2 VRTGACTCAGCA 1.6e-003 2.2e-006 -13.02 0.0 79 489 589 2930 0.16155 9.1e-009 244 3 M6366_1.02 NFAT5 MAKGRANTTTTCCRS 1.5e-034 2.0e-037 -84.52 0.0 46 486 437 2398 0.09465 8.1e-040 242 3 M6373_1.02 NFYC YAGCCAATSAGVGS 6.9e0000 9.3e-003 -4.68 0.0 119 487 769 2772 0.24435 3.8e-005 243 3 M6374_1.02 NKX2-1 STCAAGKGCH 1.6e-001 2.1e-004 -8.46 0.0 79 491 580 2991 0.16090 8.6e-007 245 3 M6384_1.02 NR1H4 AGGTCANTGACCYY 4.2e-011 5.6e-014 -30.51 0.0 53 487 411 2530 0.10883 2.3e-016 243 3 M6393_1.02 NR4A1 BTGACCTTB 7.3e-007 9.8e-010 -20.75 0.0 44 492 364 2836 0.08943 4.0e-012 245 3 M6395_1.02 NR4A3 STGACCTTTG 2.4e-013 3.2e-016 -35.66 0.0 59 491 444 2452 0.12016 1.3e-018 245 3 M6396_1.02 NR5A2 TRRCCTTGRV 2.4e-047 3.2e-050 -113.96 0.0 49 491 569 2937 0.09980 1.3e-052 245 3 M6402_1.02 OVOL1 KGTAACKGT 8.0e-002 1.1e-004 -9.14 0.0 34 492 252 2658 0.06911 4.4e-007 245 3 M6420_1.02 PLAG1 GGRGGSMHNWVKAGGGG 8.9e0000 1.2e-002 -4.43 0.0 360 484 2127 2741 0.74380 5.0e-005 241 3 M6422_1.02 PLAGL1 CRGGGGGCCC 1.4e-001 1.9e-004 -8.55 0.0 275 491 1551 2555 0.56008 7.9e-007 245 3 M6432_1.02 PPARD TGACCTTTVNCCTR 1.5e-104 2.0e-107 -245.68 0.0 53 487 750 2932 0.10883 8.2e-110 243 3 M6441_1.02 PTF1A KSRCASSTGTKSDNTTYCCYG 1.5e-009 2.0e-012 -26.96 0.0 38 480 329 2694 0.07917 8.2e-015 239 3 M6445_1.02 RARB BBBBTGACCTS 7.5e-002 1.0e-004 -9.21 0.0 82 490 592 2925 0.16735 4.1e-007 244 3 M6448_1.02 RELB RGGGRMTTTCCH 6.4e-122 8.6e-125 -285.67 0.0 53 489 785 2929 0.10838 3.5e-127 244 3 M6453_1.02 RFX3 TYRCCATGGYAACV 1.3e-003 1.8e-006 -13.23 0.0 29 487 170 1815 0.05955 7.4e-009 243 3 M6464_1.02 SMAD2 GTGTCHGKCTV 1.7e0000 2.3e-003 -6.08 0.0 170 490 1124 2919 0.34694 9.4e-006 244 3 M6465_1.02 SMAD3 STGTCTGBCY 2.1e-001 2.8e-004 -8.18 0.0 273 491 1786 2982 0.55601 1.1e-006 245 3 M6468_1.02 SNAI1 SCAGGTGK 3.8e0000 5.1e-003 -5.28 0.0 209 493 1353 2932 0.42394 2.1e-005 246 3 M6478_1.02 SOX9 ARAACAATRGR 5.4e0000 7.3e-003 -4.93 0.0 20 490 154 2696 0.04082 3.0e-005 244 3 M6498_1.02 NR5A1 TGRCCTTGR 3.6e-070 4.9e-073 -166.50 0.0 60 492 725 2959 0.12195 2.0e-075 245 3 M6513_1.02 TFAP4 RYCAGCTGYGG 2.1e-045 2.8e-048 -109.50 0.0 48 490 514 2642 0.09796 1.1e-050 244 3 M6514_1.02 TFCP2 SCCWGMNMDSRCCRGA 4.9e-012 6.6e-015 -32.65 0.0 169 485 1221 2878 0.34845 2.7e-017 242 3 M6521_1.02 THRA STGACCTSAV 5.8e0000 7.8e-003 -4.85 0.0 65 491 465 2937 0.13238 3.2e-005 245 3 M6527_1.02 TWIST1 MCCCAGGTGK 5.4e0000 7.2e-003 -4.93 0.0 211 491 1222 2605 0.42974 3.0e-005 245 3 M6542_1.02 ZBTB6 VGRTGATRGAGCC 7.9e-008 1.1e-010 -22.96 0.0 102 488 704 2630 0.20902 4.4e-013 243 3 M6548_1.02 ZIC1 KGGGWGGTV 1.6e-012 2.2e-015 -33.76 0.0 52 492 460 2925 0.10569 8.9e-018 245 3 M6549_1.02 ZIC2 DGGGTGGTC 6.7e-005 9.0e-008 -16.23 0.0 50 492 407 2961 0.10163 3.7e-010 245 3 M6550_1.02 ZIC3 BGGGTGGYC 1.1e-001 1.5e-004 -8.82 0.0 38 492 301 2941 0.07724 6.0e-007 245 3 M6554_1.02 ZNF238 TCCAGATGTTBVSS 9.8e-002 1.3e-004 -8.93 0.0 105 487 574 2213 0.21561 5.4e-007 243 3 M6559_1.02 ZNF589 CCMASGGKWWYWRCCS 2.3e-009 3.0e-012 -26.52 0.0 47 485 405 2856 0.09691 1.3e-014 242 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).