# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 RRCAGTTTCWAG MEME-1 RRCAGTTTCWAG 3.4e-072 4.6e-075 -171.16 0.0 81 189 456 563 0.42857 4.9e-077 94 1 GTTTCAAGGHHCCCC MEME-2 GTTTCAAGGHHCCCC 1.2e-034 1.6e-037 -84.73 0.0 70 186 233 314 0.37634 1.7e-039 92 2 GTTTCW DREME-1 GTTTCW 1.3e-040 1.8e-043 -98.45 0.0 81 195 338 455 0.41538 1.8e-045 97 2 CTSGAAAC DREME-2 CTGGAAAC 5.4e-006 7.3e-009 -18.74 0.0 55 193 45 67 0.28497 7.6e-011 96 3 M0630_1.02 DMRT1 WWTGTWDCNW 5.7e-003 7.8e-006 -11.77 0.0 27 191 114 494 0.14136 8.2e-008 95 3 M1266_1.02 (IRF6)_(Mus_musculus)_(DBD_1.00) NVNCGAWACY 7.5e-030 1.0e-032 -73.66 0.0 79 191 378 565 0.41361 1.1e-034 95 3 M1528_1.02 (RFX6)_(Mus_musculus)_(DBD_0.66) VCNTRGYWAC 2.2e-006 3.0e-009 -19.62 0.0 103 191 357 524 0.53927 3.2e-011 95 3 M1529_1.02 (RFX7)_(Mus_musculus)_(DBD_1.00) VCNTRGYAAC 4.9e-016 6.7e-019 -41.85 0.0 57 191 267 545 0.29843 7.0e-021 95 3 M2392_1.02 RFX2 GTYDCCATGGCAACVRVNN 3.2e-002 4.4e-005 -10.04 0.0 24 182 70 292 0.13187 4.9e-007 90 3 M4344_1.02 (ARID2)_(Saccharomyces_cerevisiae)_(DBD_0.26) SGTTGCYA 2.3e-001 3.1e-004 -8.09 0.0 23 193 86 439 0.11917 3.2e-006 96 3 M4476_1.02 RFX5 TCABYWGTTGCYRGG 2.4e-012 3.3e-015 -33.35 0.0 54 186 224 473 0.29032 3.6e-017 92 3 M4635_1.02 STAT2 GAAANYGAAACTDAA 4.9e-002 6.6e-005 -9.63 0.0 52 186 155 394 0.27957 7.2e-007 92 3 M5303_1.02 BCL6B TGCTTTCTAGGAATTCM 6.9e-001 9.3e-004 -6.98 0.0 18 184 14 39 0.09783 1.0e-005 91 3 M5544_1.02 HOXC10 DTTTWATKDB 8.9e0000 1.2e-002 -4.42 0.0 1 191 10 436 0.00524 1.3e-004 95 3 M5567_1.02 HSF4 GAANVTTCTAGAA 6.3e0000 8.5e-003 -4.77 0.0 58 188 123 299 0.30851 9.2e-005 93 3 M5643_1.02 MYBL1 RCCGTTAAACBG 7.3e0000 9.9e-003 -4.61 0.0 101 189 186 288 0.53439 1.1e-004 94 3 M5750_1.02 PRDM4 GGGGGCCTTGAAA 1.0e-027 1.4e-030 -68.73 0.0 80 188 232 305 0.42553 1.5e-032 93 3 M5777_1.02 RFX4 NGTWRCCATGGYWACS 2.7e0000 3.6e-003 -5.63 0.0 13 185 28 175 0.07027 3.9e-005 92 3 M6159_1.02 BCL6 TTCCWRGAAWGYHYWH 2.8e0000 3.7e-003 -5.59 0.0 21 185 85 483 0.11351 4.1e-005 92 3 M6185_1.02 CXXC1 CGKTGKY 1.8e-001 2.4e-004 -8.35 0.0 56 194 182 468 0.28866 2.5e-006 96 3 M6274_1.02 HIC1 GGGKTGCCC 8.1e0000 1.1e-002 -4.51 0.0 4 192 21 396 0.02083 1.2e-004 95 3 M6309_1.02 IRF3 GGAAAGBGAAASBRRRA 6.4e0000 8.6e-003 -4.75 0.0 50 184 145 405 0.27174 9.5e-005 91 3 M6312_1.02 IRF7 GAAASYGAAA 4.1e-001 5.5e-004 -7.51 0.0 47 191 173 522 0.24607 5.8e-006 95 3 M6314_1.02 IRF9 GAAAGCGAAAYT 2.6e-001 3.6e-004 -7.94 0.0 49 189 118 314 0.25926 3.8e-006 94 3 M6343_1.02 MEIS1 CDTWAAVCTGTCA 8.8e-002 1.2e-004 -9.04 0.0 26 188 92 405 0.13830 1.3e-006 93 3 M6349_1.02 MYBL2 WYAACCKSYA 1.2e0000 1.6e-003 -6.47 0.0 173 191 472 494 0.90576 1.6e-005 95 3 M6350_1.02 MYB CMGTTRD 1.2e-002 1.6e-005 -11.07 0.0 24 194 92 432 0.12371 1.6e-007 96 3 M6370_1.02 NFKB2 GRAATBYCCCT 5.6e-001 7.5e-004 -7.19 0.0 80 190 251 483 0.42105 8.0e-006 94 3 M6377_1.02 NKX2-8 TTCAAGKRC 2.5e-007 3.4e-010 -21.79 0.0 98 192 309 462 0.51042 3.6e-012 95 3 M6396_1.02 NR5A2 TRRCCTTGRV 3.9e-006 5.3e-009 -19.06 0.0 65 191 233 481 0.34031 5.5e-011 95 3 M6416_1.02 CBFB YYTGTGGTYDB 1.4e-002 1.8e-005 -10.91 0.0 98 190 318 506 0.51579 1.9e-007 94 3 M6451_1.02 RFX1 GTTGCYAGGSRA 1.9e0000 2.6e-003 -5.96 0.0 29 189 93 404 0.15344 2.7e-005 94 3 M6453_1.02 RFX3 TYRCCATGGYAACV 2.5e0000 3.4e-003 -5.70 0.0 51 187 85 211 0.27273 3.6e-005 93 3 M6498_1.02 NR5A1 TGRCCTTGR 1.1e0000 1.5e-003 -6.51 0.0 42 192 144 477 0.21875 1.6e-005 95 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).