# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 AGRRARRGAAAGRRARRGARAG MEME-1 AGRRARRGAAAGRRARRGARAG 3.4e-082 4.6e-085 -194.20 0.0 113 479 362 582 0.23591 1.9e-087 239 1 YTYCCTTTCYYT MEME-2 YTYCCTTTCYYT 1.1e-086 1.5e-089 -204.55 0.0 135 489 405 599 0.27607 6.0e-092 244 1 RRRARRGAAAGRRARRGARARR MEME-3 RRRARRGAAAGRRARRGARARR 3.1e-070 4.1e-073 -166.67 0.0 143 479 372 547 0.29854 1.7e-075 239 1 RRGAAAGRAARRGARA MEME-4 RRGAAAGRAARRGARA 5.0e-067 6.7e-070 -159.28 0.0 125 485 362 596 0.25773 2.8e-072 242 1 CTTTCYYTY MEME-5 CTTTCYYTY 4.1e-059 5.4e-062 -141.07 0.0 182 492 426 599 0.36992 2.2e-064 245 2 GAAAGGMA DREME-1 GAAAGGAA 1.1e-061 1.5e-064 -146.96 0.0 155 493 268 351 0.31440 6.1e-067 246 2 GRGAAAGB DREME-2 GRGAAAGG 9.7e-070 1.3e-072 -165.53 0.0 107 493 281 457 0.21704 5.3e-075 246 2 ACTYTC DREME-3 ACTYTC 3.7e-012 5.0e-015 -32.93 0.0 119 495 163 369 0.24040 2.0e-017 247 3 M0714_1.02 (ENSG00000235187)_(Mus_musculus)_(DBD_1.00) NDNMGGAWRY 3.4e-004 4.6e-007 -14.59 0.0 149 491 248 591 0.30346 1.9e-009 245 3 M1882_1.02 IRF1 AAANNGAAAGTGAAASYRRRN 8.9e-064 1.2e-066 -151.80 0.0 162 480 410 593 0.33750 5.0e-069 239 3 M2273_1.02 E2F6 RGGCGGGARRV 4.9e-001 6.5e-004 -7.33 0.0 304 490 422 594 0.62041 2.7e-006 244 3 M2275_1.02 ELF1 RRAVCMGGAAGTG 9.2e-013 1.2e-015 -34.32 0.0 174 488 314 592 0.35656 5.1e-018 243 3 M2277_1.02 FLI1 RCAGGAAGTGR 7.5e-012 1.0e-014 -32.23 0.0 116 490 231 591 0.23673 4.1e-017 244 3 M2283_1.02 FOXP1 HWWADGTAAACAAAR 2.1e-001 2.8e-004 -8.18 0.0 206 486 293 559 0.42387 1.2e-006 242 3 M2307_1.02 PRDM1 DRAAAGTGAAAGTRA 9.7e-101 1.3e-103 -236.90 0.0 118 486 400 600 0.24280 5.4e-106 242 3 M2313_1.02 (SOX6)_(Mus_musculus)_(DBD_1.00) CCWTTGTYYY 1.5e-004 2.0e-007 -15.45 0.0 145 491 240 581 0.29532 8.0e-010 245 3 M2319_1.02 TCF7L2 TBYCTTTGAWSTYN 1.4e-006 1.8e-009 -20.13 0.0 251 487 372 567 0.51540 7.5e-012 243 3 M2390_1.02 EHF SAGGAAGK 5.3e-006 7.2e-009 -18.75 0.0 171 493 276 575 0.34686 2.9e-011 246 3 M4453_1.02 BCL11A ADGRGGAASTGAAAV 5.2e-064 7.0e-067 -152.33 0.0 134 486 372 599 0.27572 2.9e-069 242 3 M4463_1.02 IRF4 DNWSNRGAAVTGAVWSWD 8.7e-016 1.2e-018 -41.29 0.0 199 483 360 598 0.41201 4.9e-021 241 3 M4545_1.02 ZNF683 DRAAAGTGAAAGTGV 3.5e-089 4.7e-092 -210.29 0.0 124 486 394 600 0.25514 1.9e-094 242 3 M4604_1.02 ZNF263 RRGGAGGASGVVGRGGRGGRG 1.9e-009 2.6e-012 -26.68 0.0 178 480 312 594 0.37083 1.1e-014 239 3 M4635_1.02 STAT2 GAAANYGAAACTDAA 3.9e-048 5.3e-051 -115.77 0.0 166 486 380 580 0.34156 2.2e-053 242 3 M5421_1.02 ETV2 AACCGGAAATR 5.0e-008 6.7e-011 -23.42 0.0 152 490 230 494 0.31020 2.8e-013 244 3 M5425_1.02 ETV6 CCGGAASCGGAAGYR 1.5e-004 2.1e-007 -15.40 0.0 84 486 123 418 0.17284 8.5e-010 242 3 M5865_1.02 SPIC HAAAAGVGGAAGTA 1.6e-025 2.1e-028 -63.73 0.0 197 487 376 587 0.40452 8.7e-031 243 3 M5875_1.02 TBX1 AGGTGTGAAAAAAGGTGTGA 4.3e-002 5.8e-005 -9.75 0.0 431 481 273 280 0.89605 2.4e-007 240 3 M5903_1.02 TCF7L1 AAAGATCAAAGG 1.3e-012 1.7e-015 -33.99 0.0 181 489 298 539 0.37014 7.1e-018 244 3 M5970_1.02 ZNF282 VTCGTGTTRKGGGAAAG 2.4e-008 3.2e-011 -24.17 0.0 78 484 119 381 0.16116 1.3e-013 241 3 M5976_1.02 ZNF713 TTCGTGGCATTYTTCTA 4.8e-006 6.4e-009 -18.86 0.0 222 484 161 239 0.45868 2.7e-011 241 3 M6111_1.02 (ZNF652)_(Mus_musculus)_(DBD_1.00) NBAAAGGGTTAAH 8.5e-003 1.1e-005 -11.38 0.0 70 488 90 355 0.14344 4.7e-008 243 3 M6119_1.02 SPI1 RAAAAGAGGAAGTGV 6.2e-040 8.3e-043 -96.89 0.0 128 486 319 595 0.26337 3.4e-045 242 3 M6154_1.02 ATF5 TAAGGRAGARGK 5.2e-041 7.0e-044 -99.36 0.0 185 489 399 598 0.37832 2.9e-046 244 3 M6196_1.02 E2F7 WWDGGCGCGAAAM 2.6e-020 3.5e-023 -51.70 0.0 154 488 237 422 0.31557 1.5e-025 243 3 M6204_1.02 ELF2 TDNCAGGAAGTRRVT 1.2e-001 1.6e-004 -8.72 0.0 192 486 286 577 0.39506 6.7e-007 242 3 M6205_1.02 ELF3 GGSAAACAGGAARY 1.3e-004 1.8e-007 -15.54 0.0 193 487 291 555 0.39630 7.3e-010 243 3 M6206_1.02 ELF5 AHMAGGAWRTW 1.2e-007 1.6e-010 -22.56 0.0 172 490 289 584 0.35102 6.5e-013 244 3 M6207_1.02 ELK1 RCCGGAAGT 1.8e-002 2.5e-005 -10.62 0.0 174 492 267 581 0.35366 1.0e-007 245 3 M6221_1.02 ETS2 VMVGGAAGTKS 1.2e-014 1.6e-017 -38.66 0.0 180 490 329 597 0.36735 6.7e-020 244 3 M6222_1.02 ETV4 SAGGAAGY 7.3e-006 9.8e-009 -18.44 0.0 205 493 329 599 0.41582 4.0e-011 246 3 M6223_1.02 ETV5 GHCAGGAAGWWAY 7.7e-004 1.0e-006 -13.79 0.0 206 488 318 588 0.42213 4.2e-009 243 3 M6225_1.02 MECOM WAGAYAAGATAANAKA 8.0e-002 1.1e-004 -9.14 0.0 201 485 260 494 0.41443 4.4e-007 242 3 M6226_1.02 FEV CAGGAARTDA 2.7e0000 3.6e-003 -5.63 0.0 213 491 300 576 0.43381 1.5e-005 245 3 M6308_1.02 IRF2 SGAAAGYGAAASYV 8.7e-068 1.2e-070 -161.03 0.0 117 487 349 592 0.24025 4.8e-073 243 3 M6309_1.02 IRF3 GGAAAGBGAAASBRRRA 1.1e-073 1.5e-076 -174.56 0.0 118 484 360 592 0.24380 6.4e-079 241 3 M6311_1.02 IRF5 KAAAGGRAARCMAAAWSWGA 3.9e-050 5.2e-053 -120.38 0.0 165 481 353 518 0.34304 2.2e-055 240 3 M6312_1.02 IRF7 GAAASYGAAA 1.1e-054 1.5e-057 -130.84 0.0 119 491 327 587 0.24236 6.1e-060 245 3 M6313_1.02 IRF8 GRGRAAVTGAAASYR 3.1e-071 4.2e-074 -168.96 0.0 122 486 365 598 0.25103 1.7e-076 242 3 M6314_1.02 IRF9 GAAAGCGAAAYT 3.6e-024 4.8e-027 -60.61 0.0 117 489 242 519 0.23926 2.0e-029 244 3 M6336_1.02 MAZ RGGGDRGGGAGGGRGGG 5.2e-004 7.0e-007 -14.17 0.0 114 484 202 590 0.23554 2.9e-009 241 3 M6356_1.02 MZF1 RGDGGGGAD 2.0e0000 2.7e-003 -5.91 0.0 190 492 278 588 0.38618 1.1e-005 245 3 M6363_1.02 NFATC2 RWTTTTCCA 1.4e-007 1.8e-010 -22.42 0.0 126 492 229 587 0.25610 7.5e-013 245 3 M6365_1.02 NFATC4 WADTTTTCCH 1.2e-016 1.7e-019 -43.25 0.0 155 491 298 589 0.31568 6.7e-022 245 3 M6381_1.02 NR0B1 YSTCCCMCKC 3.0e-004 4.0e-007 -14.74 0.0 269 491 397 595 0.54786 1.6e-009 245 3 M6383_1.02 NR1H2 MGTTGACCTTTGACCTTTA 6.8e0000 9.1e-003 -4.70 0.0 148 482 38 69 0.30705 3.8e-005 240 3 M6391_1.02 NR2E3 TGACTTTTGACTTT 1.8e-005 2.4e-008 -17.56 0.0 115 487 202 566 0.23614 9.7e-011 243 3 M6392_1.02 NR2F6 YYMNNTGAMCTTTGWCCY 1.4e-034 1.9e-037 -84.55 0.0 175 483 375 597 0.36232 7.9e-040 241 3 M6420_1.02 PLAG1 GGRGGSMHNWVKAGGGG 2.3e-002 3.1e-005 -10.39 0.0 178 484 274 578 0.36777 1.3e-007 241 3 M6425_1.02 POU3F1 HTTGCATWWSMATB 5.3e-002 7.1e-005 -9.56 0.0 91 487 147 531 0.18686 2.9e-007 243 3 M6432_1.02 PPARD TGACCTTTNNCCTR 7.8e-010 1.0e-012 -27.58 0.0 83 487 176 584 0.17043 4.3e-015 243 3 M6433_1.02 PPARG GKKMMCTTTGACCYASWT 5.9e-009 7.9e-012 -25.56 0.0 149 483 271 595 0.30849 3.3e-014 241 3 M6446_1.02 RARG BTGACCTBYNGBYGAMCYCC 3.6e-001 4.8e-004 -7.64 0.0 169 481 259 582 0.35135 2.0e-006 240 3 M6474_1.02 SOX18 GGAMRAVAACAAWKBDWDS 1.3e-002 1.7e-005 -10.95 0.0 100 482 165 541 0.20747 7.3e-008 240 3 M6476_1.02 SOX4 GAGAACAAAGSG 2.3e-006 3.1e-009 -19.58 0.0 175 489 287 581 0.35787 1.3e-011 244 3 M6485_1.02 SPIB ARAAASMGGAAS 3.9e-025 5.2e-028 -62.82 0.0 125 489 279 587 0.25562 2.1e-030 244 3 M6515_1.02 TFDP1 AWWKRGCGGGAAAY 1.4e0000 1.8e-003 -6.31 0.0 307 487 349 482 0.63039 7.5e-006 243 3 M6557_1.02 ZNF384 GSAAAAAVYMBS 3.5e-003 4.7e-006 -12.26 0.0 185 489 280 569 0.37832 1.9e-008 244 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).