# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 GGRGGVGGRGGGRGGGGGGGRG MEME-1 GGRGGVGGRGGGRGGGGGGGRG 9.2e-019 1.2e-021 -48.15 0.0 85 479 209 595 0.17745 5.1e-024 239 1 SCCCCKCCC MEME-2 SCCCCKCCC 6.7e-009 8.9e-012 -25.44 0.0 54 492 127 581 0.10976 3.6e-014 245 1 TGACTCA MEME-5 TGACTCA 2.5e0000 3.4e-003 -5.70 0.0 130 494 40 83 0.26316 1.4e-005 246 1 GGGGGCWGG MEME-9 GGGGGCWGG 2.0e-004 2.6e-007 -15.14 0.0 72 492 39 96 0.14634 1.1e-009 245 2 GCCCCCD DREME-1 GCCCCCD 4.7e-023 6.3e-026 -58.02 0.0 92 494 193 479 0.18623 2.6e-028 246 2 CCCCDCCC DREME-2 CCCCDCCC 8.2e-007 1.1e-009 -20.63 0.0 81 493 135 463 0.16430 4.5e-012 246 3 M0404_1.02 (ZNF202)_(Mus_musculus)_(DBD_0.87) NNNBGGGGSV 2.9e-001 3.9e-004 -7.85 0.0 109 491 182 598 0.22200 1.6e-006 245 3 M0422_1.02 (ZIC5)_(Mus_musculus)_(DBD_0.99) SYRGGGGGTM 2.9e-008 3.9e-011 -23.98 0.0 139 491 254 600 0.28310 1.6e-013 245 3 M1871_1.02 (KLF2)_(Mus_musculus)_(DBD_0.95) DGGGYGKGGC 1.1e-002 1.4e-005 -11.15 0.0 129 491 217 599 0.26273 5.9e-008 245 3 M1906_1.02 SP1 GGGGGMGGGGC 1.3e-003 1.7e-006 -13.28 0.0 114 490 201 599 0.23265 7.0e-009 244 3 M2273_1.02 E2F6 RGGCGGGARRV 4.0e-001 5.3e-004 -7.54 0.0 140 490 223 598 0.28571 2.2e-006 244 3 M2314_1.02 SP2 SSSVRGRGGCGGGRC 5.5e-001 7.3e-004 -7.22 0.0 286 486 406 597 0.58848 3.0e-006 242 3 M2391_1.02 KLF5 DGGGHGGGGC 2.2e-002 2.9e-005 -10.46 0.0 263 491 385 600 0.53564 1.2e-007 245 3 M4427_1.02 CTCF NYGGCCASCAGRKGGCRSYVB 4.1e-001 5.5e-004 -7.51 0.0 232 480 299 510 0.48333 2.3e-006 239 3 M4459_1.02 EGR1 SBGCGKGGGCGGVGGSGSGS 1.9e-005 2.5e-008 -17.50 0.0 133 481 235 588 0.27651 1.0e-010 240 3 M4612_1.02 CTCFL CCRSCAGGGGGCGCY 2.8e-005 3.7e-008 -17.11 0.0 144 486 232 547 0.29630 1.5e-010 242 3 M4640_1.02 ZBTB7A GGGSRRGGGKCBSBG 1.7e-006 2.3e-009 -19.89 0.0 50 486 117 597 0.10288 9.5e-012 242 3 M5491_1.02 GLIS2 CDYYGCGGGGGGTC 6.8e-006 9.1e-009 -18.51 0.0 89 487 146 473 0.18275 3.7e-011 243 3 M5592_1.02 KLF14 ARGKGGGCGTGGYM 8.2e-001 1.1e-003 -6.82 0.0 197 487 280 561 0.40452 4.5e-006 243 3 M5593_1.02 KLF16 GGGGGCGTGKC 1.0e-008 1.4e-011 -24.99 0.0 126 490 236 594 0.25714 5.7e-014 244 3 M5856_1.02 SP8 RGKGGGCGTGGY 2.0e-003 2.7e-006 -12.82 0.0 161 489 264 599 0.32924 1.1e-008 244 3 M5965_1.02 ZIC4 DCDCMGCGGGGGGYC 1.4e-003 1.9e-006 -13.18 0.0 124 486 203 557 0.25514 7.8e-009 242 3 M5977_1.02 ZNF740 GTGGGGGGGK 2.5e-012 3.4e-015 -33.33 0.0 277 491 435 593 0.56415 1.4e-017 245 3 M6123_1.02 (ZNF281)_(Mus_musculus)_(DBD_1.00) GRGKKGGGGGAGGGG 1.1e-008 1.4e-011 -24.99 0.0 278 486 431 599 0.57202 5.8e-014 242 3 M6199_1.02 EGR2 DGVGTGGGCGG 8.5e-007 1.1e-009 -20.59 0.0 58 490 130 593 0.11837 4.7e-012 244 3 M6201_1.02 EGR4 GGSGGYRGGGM 3.6e-004 4.8e-007 -14.55 0.0 126 490 217 590 0.25714 2.0e-009 244 3 M6212_1.02 EPAS1 CMCACGYAYDCAC 3.4e0000 4.5e-003 -5.40 0.0 268 488 351 552 0.54918 1.9e-005 243 3 M6267_1.02 GLIS3 GYGGGGGGTM 7.7e-016 1.0e-018 -41.41 0.0 137 491 272 591 0.27902 4.2e-021 245 3 M6306_1.02 INSM1 TGTMAGGGGGCR 4.3e-007 5.7e-010 -21.28 0.0 93 489 164 514 0.19018 2.3e-012 244 3 M6321_1.02 KLF15 RSMKGGGAGDKGGGGSS 3.7e-007 5.0e-010 -21.42 0.0 272 484 419 597 0.56198 2.1e-012 241 3 M6322_1.02 KLF1 CAGGGTGKGGC 5.4e-001 7.2e-004 -7.23 0.0 130 490 208 592 0.26531 3.0e-006 244 3 M6324_1.02 KLF4 DGGGYGKGGC 1.5e-003 2.0e-006 -13.14 0.0 265 491 392 599 0.53971 8.0e-009 245 3 M6325_1.02 KLF6 GGGGGCKG 1.8e-011 2.3e-014 -31.38 0.0 83 493 183 598 0.16836 9.5e-017 246 3 M6326_1.02 KLF8 CMGGGKGTG 7.5e-001 1.0e-003 -6.91 0.0 296 492 393 567 0.60163 4.1e-006 245 3 M6336_1.02 MAZ RGGGRGGGGAGGGRGGG 3.3e-009 4.5e-012 -26.14 0.0 156 484 283 599 0.32231 1.8e-014 241 3 M6356_1.02 MZF1 RGDGGGGAD 2.5e0000 3.4e-003 -5.69 0.0 96 492 158 592 0.19512 1.4e-005 245 3 M6381_1.02 NR0B1 YSTCCCMCKC 1.4e-001 1.9e-004 -8.58 0.0 105 491 179 598 0.21385 7.6e-007 245 3 M6420_1.02 PLAG1 GGRGGSMHNDVKAGGGG 1.8e-006 2.4e-009 -19.83 0.0 160 484 277 596 0.33058 1.0e-011 241 3 M6422_1.02 PLAGL1 CRGGGGGCCC 1.1e-012 1.4e-015 -34.19 0.0 101 491 208 576 0.20570 5.8e-018 245 3 M6442_1.02 PURA CCMBGCCCNCCMMBWCC 1.7e-001 2.2e-004 -8.40 0.0 136 484 223 600 0.28099 9.3e-007 241 3 M6482_1.02 SP3 SGVVGGGGGCGGGGCBRGSS 4.7e-004 6.3e-007 -14.28 0.0 55 481 119 600 0.11435 2.6e-009 240 3 M6483_1.02 SP4 GSGGSCRGGGGSGGGGSGGSSSSG 3.5e-009 4.7e-012 -26.09 0.0 131 477 243 574 0.27463 2.0e-014 238 3 M6535_1.02 WT1 GMGGGGGCGKGGG 1.1e-011 1.5e-014 -31.81 0.0 118 488 236 596 0.24180 6.3e-017 243 3 M6539_1.02 ZBTB7B CGGVGRRGGGGMGSRGGSGGGH 1.2e-009 1.7e-012 -27.12 0.0 123 479 236 585 0.25678 7.0e-015 239 3 M6548_1.02 ZIC1 KGGGWGGTS 2.9e-005 3.9e-008 -17.07 0.0 212 492 335 599 0.43089 1.6e-010 245 3 M6549_1.02 ZIC2 KGGGTGGTC 3.5e-001 4.7e-004 -7.67 0.0 248 492 358 598 0.50407 1.9e-006 245 3 M6552_1.02 ZNF148 KGVGKGGGGGMGGGG 2.9e-013 3.8e-016 -35.49 0.0 134 486 265 598 0.27572 1.6e-018 242 3 M6553_1.02 ZNF219 GDGGGGGGYGGA 2.5e-006 3.4e-009 -19.50 0.0 99 489 190 595 0.20245 1.4e-011 244 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).