# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 SGRRGKGGGCGTGGCC MEME-1 SGRRGKGGGCGTGGCC 2.2e-139 3.0e-142 -325.87 0.0 77 485 373 599 0.15876 1.2e-144 242 1 GKGGGCGKGGCC MEME-2 GKGGGCGKGGCC 2.3e-116 3.1e-119 -272.87 0.0 83 489 354 589 0.16973 1.3e-121 244 1 ACACACACACACRCACACACMC MEME-3 ACACACACACACRCACACACMC 1.5e-002 2.1e-005 -10.78 0.0 121 479 47 91 0.25261 8.7e-008 239 2 CMCGCCCH DREME-1 CMCGCCCM 2.0e-091 2.8e-094 -215.43 0.0 95 493 328 548 0.19270 1.1e-096 246 2 CACACCCM DREME-2 CACACCCM 2.7e-018 3.7e-021 -47.06 0.0 95 493 94 178 0.19270 1.5e-023 246 2 AGGCGYG DREME-3 AGGCGYG 1.0e-008 1.4e-011 -25.02 0.0 90 494 82 201 0.18219 5.6e-014 246 2 CACGTGAY DREME-4 CACGTGAC 3.4e-001 4.5e-004 -7.70 0.0 99 493 47 122 0.20081 1.8e-006 246 3 M0305_1.02 (CREB3L2)_(Mus_musculus)_(DBD_1.00) GCCACGTGD 9.7e0000 1.3e-002 -4.34 0.0 76 492 105 469 0.15447 5.4e-005 245 3 M0405_1.02 (KLF7)_(Mus_musculus)_(DBD_1.00) DGGGCGKGGY 3.5e-099 4.7e-102 -233.32 0.0 99 491 365 600 0.20163 1.9e-104 245 3 M0422_1.02 (ZIC5)_(Mus_musculus)_(DBD_0.99) SYRGGGGGTM 3.2e0000 4.3e-003 -5.46 0.0 67 491 119 598 0.13646 1.7e-005 245 3 M0443_1.02 (KLF12)_(Mus_musculus)_(DBD_1.00) DGGGCGKGGY 1.0e-092 1.4e-095 -218.43 0.0 73 491 309 600 0.14868 5.6e-098 245 3 M1871_1.02 (KLF2)_(Mus_musculus)_(DBD_0.95) DGGGYGKGGC 1.1e-096 1.5e-099 -227.55 0.0 99 491 362 600 0.20163 6.1e-102 245 3 M1906_1.02 SP1 GGGGGMGGGGC 6.1e-031 8.3e-034 -76.17 0.0 146 490 325 595 0.29796 3.4e-036 244 3 M2314_1.02 SP2 SSSVRGRGGCGGGRC 3.3e-024 4.4e-027 -60.69 0.0 138 486 301 598 0.28395 1.8e-029 242 3 M2391_1.02 KLF5 DGGGHGGGGC 1.1e-060 1.5e-063 -144.66 0.0 81 491 280 600 0.16497 6.1e-066 245 3 M4459_1.02 EGR1 SBGCGKGGGCGGVGGSGSGS 2.4e-028 3.3e-031 -70.20 0.0 73 481 209 592 0.15177 1.4e-033 240 3 M4481_1.02 USF2 GGTCACGTGRSSSSV 2.2e-001 3.0e-004 -8.12 0.0 72 486 95 397 0.14815 1.2e-006 242 3 M4612_1.02 CTCFL CCRSCAGGGGGCGCY 5.6e-002 7.5e-005 -9.49 0.0 182 486 257 534 0.37449 3.1e-007 242 3 M4640_1.02 ZBTB7A GGGSRRGGGKCBSBG 1.3e-015 1.7e-018 -40.92 0.0 116 486 246 597 0.23868 7.0e-021 242 3 M5209_1.02 (SP5)_(Drosophila_melanogaster)_(DBD_0.93) GKGGGCGKRKC 3.5e-117 4.7e-120 -274.77 0.0 78 490 349 600 0.15918 1.9e-122 244 3 M5325_1.02 CREB3L1 TGRTGACGTGGCAB 5.2e0000 7.0e-003 -4.96 0.0 79 487 90 369 0.16222 2.9e-005 243 3 M5591_1.02 KLF13 CAAAAAGGGGCGTGKCAY 1.3e-082 1.8e-085 -195.14 0.0 95 483 311 525 0.19669 7.4e-088 241 3 M5592_1.02 KLF14 ARGKGGGCGTGGYM 3.4e-124 4.6e-127 -290.91 0.0 87 487 375 599 0.17864 1.9e-129 243 3 M5593_1.02 KLF16 GGGGGCGTGKC 2.5e-124 3.4e-127 -291.19 0.0 98 490 394 600 0.20000 1.4e-129 244 3 M5856_1.02 SP8 RGKGGGCGTGGY 2.0e-108 2.7e-111 -254.60 0.0 79 489 341 600 0.16155 1.1e-113 244 3 M5962_1.02 ZBTB7C NTCGGTGGTCGY 1.7e-002 2.3e-005 -10.68 0.0 49 489 100 582 0.10020 9.4e-008 244 3 M5977_1.02 ZNF740 GTGGGGGGGK 2.0e-014 2.7e-017 -38.15 0.0 63 491 158 590 0.12831 1.1e-019 245 3 M6123_1.02 (ZNF281)_(Mus_musculus)_(DBD_1.00) GRGKKGGGGGAGGGG 2.0e-004 2.7e-007 -15.11 0.0 80 486 154 584 0.16461 1.1e-009 242 3 M6139_1.02 AHR KCACGCRAH 6.7e-008 9.0e-011 -23.13 0.0 128 492 231 580 0.26016 3.7e-013 245 3 M6150_1.02 ARNT2 GYSYSCCACGNC 2.1e-002 2.9e-005 -10.45 0.0 67 489 128 592 0.13701 1.2e-007 244 3 M6155_1.02 ATF6 GBGSTGACGTGG 8.8e-003 1.2e-005 -11.35 0.0 85 489 123 445 0.17382 4.8e-008 244 3 M6191_1.02 E2F2 GGCGCGAAAC 5.9e-001 8.0e-004 -7.14 0.0 237 491 314 541 0.48269 3.3e-006 245 3 M6199_1.02 EGR2 DGVGTGGGCGG 1.7e-032 2.3e-035 -79.74 0.0 92 490 248 598 0.18776 9.6e-038 244 3 M6200_1.02 EGR3 WGAGTGGGYGT 2.7e-030 3.6e-033 -74.70 0.0 96 490 246 585 0.19592 1.5e-035 244 3 M6201_1.02 EGR4 GGSGGYRGGGM 1.1e-017 1.5e-020 -45.67 0.0 78 490 190 586 0.15918 6.0e-023 244 3 M6212_1.02 EPAS1 CMCACGYAYDCAC 4.1e-008 5.5e-011 -23.62 0.0 76 488 158 572 0.15574 2.3e-013 243 3 M6265_1.02 GLI2 GTGGGTGGTCY 2.5e0000 3.4e-003 -5.70 0.0 42 490 61 403 0.08571 1.4e-005 244 3 M6275_1.02 HIF1A SBSTACGTGCSB 8.4e0000 1.1e-002 -4.48 0.0 107 489 157 537 0.21881 4.7e-005 244 3 M6306_1.02 INSM1 TGTMAGGGGGCR 1.1e-003 1.5e-006 -13.41 0.0 65 489 115 509 0.13292 6.2e-009 244 3 M6321_1.02 KLF15 RSMKGGGAGDKGGGGSS 1.0e-002 1.4e-005 -11.18 0.0 64 484 125 591 0.13223 5.8e-008 241 3 M6322_1.02 KLF1 CAGGGTGKGGC 3.1e-017 4.2e-020 -44.61 0.0 58 490 156 587 0.11837 1.7e-022 244 3 M6323_1.02 KLF3 HRCYWGGGTGKGGCT 1.9e-001 2.6e-004 -8.25 0.0 38 486 72 515 0.07819 1.1e-006 242 3 M6324_1.02 KLF4 DGGGYGKGGC 1.3e-088 1.8e-091 -208.97 0.0 99 491 351 600 0.20163 7.2e-094 245 3 M6325_1.02 KLF6 GGGGGCKG 1.6e-004 2.1e-007 -15.36 0.0 157 493 259 593 0.31846 8.7e-010 246 3 M6326_1.02 KLF8 CMGGGKGTG 4.9e-007 6.6e-010 -21.14 0.0 170 492 275 563 0.34553 2.7e-012 245 3 M6442_1.02 PURA CCMBGCCCNCCMMBWCC 8.2e-002 1.1e-004 -9.10 0.0 92 484 163 598 0.19008 4.6e-007 241 3 M6456_1.02 RREB1 DKGKKKGKGGKTGKTTKGGGKT 1.4e-001 1.9e-004 -8.58 0.0 81 479 123 479 0.16910 7.8e-007 239 3 M6482_1.02 SP3 SGVVGGGGGCGGGGCBRGSS 7.2e-050 9.7e-053 -119.77 0.0 83 481 268 599 0.17256 4.0e-055 240 3 M6483_1.02 SP4 GSGGSCRGGGGSGGGGSGGSSSSG 2.0e-005 2.7e-008 -17.41 0.0 91 477 171 564 0.19078 1.2e-010 238 3 M6535_1.02 WT1 GMGGGGGCGKGGG 6.8e-044 9.2e-047 -106.00 0.0 96 488 277 598 0.19672 3.8e-049 243 3 M6536_1.02 XBP1 GACGTGKCMHWW 3.3e-003 4.4e-006 -12.33 0.0 49 489 82 436 0.10020 1.8e-008 244 3 M6539_1.02 ZBTB7B CGGVGRRGGGGMGSRGGSGGGH 9.0e-002 1.2e-004 -9.02 0.0 235 479 338 569 0.49061 5.1e-007 239 3 M6552_1.02 ZNF148 KGVGKGGGGGMGGGG 8.4e-005 1.1e-007 -15.99 0.0 154 486 258 590 0.31687 4.7e-010 242 3 M6553_1.02 ZNF219 GDGGGGGGYGGA 2.5e-007 3.4e-010 -21.79 0.0 139 489 250 596 0.28425 1.4e-012 244 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).