# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 TGTGTGTGTGTGTGTG MEME-1 TGTGTGTGTGTGTGTG 4.1e-018 5.4e-021 -46.67 0.0 115 485 350 908 0.23711 2.2e-023 242 1 CACACACAMMMMMACACACACA MEME-3 CACACACAMMMMMACACACACA 4.0e-001 5.4e-004 -7.53 0.0 85 479 323 1433 0.17745 2.2e-006 239 2 CMCGCCCH DREME-1 CMCGCCCM 1.3e-008 1.8e-011 -24.75 0.0 265 493 948 1499 0.53753 7.2e-014 246 2 TGABTCA DREME-2 TGASTCA 2.6e-004 3.4e-007 -14.90 0.0 136 494 214 544 0.27530 1.4e-009 246 2 ACTTCCGB DREME-4 ACTTCCGG 9.1e-004 1.2e-006 -13.62 0.0 121 493 131 337 0.24544 4.9e-009 246 2 GGGYGGAK DREME-5 GGGYGGAK 1.6e-002 2.1e-005 -10.79 0.0 291 493 581 858 0.59026 8.4e-008 246 2 TGAYGTMA DREME-9 TGAYGTCA 2.4e-003 3.1e-006 -12.68 0.0 285 493 185 247 0.57809 1.3e-008 246 2 ACWCACCC DREME-15 ACACACCC 8.0e-001 1.1e-003 -6.85 0.0 127 493 159 451 0.25761 4.3e-006 246 3 M0189_1.02 (ID2)_(Mus_musculus)_(DBD_0.98) RCACGTGR 1.2e-001 1.6e-004 -8.74 0.0 161 493 899 2406 0.32657 6.5e-007 246 3 M0211_1.02 (MLXIP)_(Mus_musculus)_(DBD_0.82) BCACGTGK 7.3e0000 9.7e-003 -4.63 0.0 153 493 845 2427 0.31034 4.0e-005 246 3 M0305_1.02 (CREB3L2)_(Mus_musculus)_(DBD_1.00) GCCACGTGD 4.5e0000 6.0e-003 -5.11 0.0 180 492 845 2065 0.36585 2.5e-005 245 3 M0405_1.02 (KLF7)_(Mus_musculus)_(DBD_1.00) DGGGCGKGGY 3.8e-012 5.1e-015 -32.91 0.0 303 491 2020 2920 0.61711 2.1e-017 245 3 M0432_1.02 (ZFP161)_(Mus_musculus)_(DBD_1.00) NNCGYGCHH 8.7e-001 1.1e-003 -6.77 0.0 192 492 901 2056 0.39024 4.7e-006 245 3 M0443_1.02 (KLF12)_(Mus_musculus)_(DBD_1.00) DGGGCGKGKY 4.8e-010 6.3e-013 -28.09 0.0 303 491 2014 2933 0.61711 2.6e-015 245 3 M1545_1.02 GMEB1 NNNRCGTNN 1.0e-001 1.4e-004 -8.91 0.0 438 492 2086 2265 0.89024 5.5e-007 245 3 M1871_1.02 (KLF2)_(Mus_musculus)_(DBD_0.95) DGGGYGKGGC 2.2e-007 2.9e-010 -21.96 0.0 263 491 1720 2863 0.53564 1.2e-012 245 3 M1906_1.02 SP1 GGGGGMGGGGC 9.0e0000 1.2e-002 -4.43 0.0 262 490 1583 2769 0.53469 4.9e-005 244 3 M1917_1.02 USF1 GGTCACRTGRB 1.9e-001 2.5e-004 -8.28 0.0 398 490 1861 2187 0.81224 1.0e-006 244 3 M2314_1.02 SP2 SSSVRGRGGCGGGRC 5.3e-002 7.0e-005 -9.56 0.0 234 486 1441 2722 0.48148 2.9e-007 242 3 M2391_1.02 KLF5 DGGGHGGGGC 1.3e-001 1.7e-004 -8.70 0.0 267 491 1693 2875 0.54379 6.8e-007 245 3 M4459_1.02 EGR1 SBGCGKGGGCGGVGGSGSGS 4.2e-008 5.6e-011 -23.60 0.0 215 481 1397 2704 0.44699 2.3e-013 240 3 M4536_1.02 E2F1 VRRVRGVGCGCGCRS 2.4e0000 3.2e-003 -5.74 0.0 178 486 975 2388 0.36626 1.3e-005 242 3 M5209_1.02 (SP5)_(Drosophila_melanogaster)_(DBD_0.93) GKGGGCGKRKC 2.0e-017 2.7e-020 -45.07 0.0 296 490 1977 2857 0.60408 1.1e-022 244 3 M5293_1.02 ATF7 NKATGACGTCATHN 2.1e0000 2.7e-003 -5.90 0.0 297 487 668 989 0.60986 1.1e-005 243 3 M5302_1.02 BATF3 TGATGACGTCATCA 1.5e0000 2.1e-003 -6.19 0.0 183 487 249 532 0.37577 8.5e-006 243 3 M5323_1.02 CREB3 KGRTGACGTCAYNV 5.9e0000 7.8e-003 -4.85 0.0 183 487 474 1089 0.37577 3.2e-005 243 3 M5493_1.02 GMEB2 KTRCGTAA 3.6e0000 4.8e-003 -5.34 0.0 451 493 2218 2365 0.91481 2.0e-005 246 3 M5509_1.02 HEY1 GRCACGTGBC 4.5e-003 6.0e-006 -12.02 0.0 181 491 907 2128 0.36864 2.4e-008 245 3 M5591_1.02 KLF13 CAAAAAGGGGCGTGKCAY 4.1e-008 5.5e-011 -23.62 0.0 319 483 1240 1669 0.66046 2.3e-013 241 3 M5592_1.02 KLF14 ARGKGGGCGTGGYM 9.7e-018 1.3e-020 -45.80 0.0 147 487 1031 2630 0.30185 5.3e-023 243 3 M5593_1.02 KLF16 GGGGGCGTGKC 3.1e-015 4.1e-018 -40.03 0.0 150 490 1101 2840 0.30612 1.7e-020 244 3 M5856_1.02 SP8 RGKGGGCGTGGY 1.8e-013 2.3e-016 -36.00 0.0 263 489 1800 2910 0.53783 9.5e-019 244 3 M5875_1.02 TBX1 AGGTGTGAAAAAAGGTGTGA 5.4e0000 7.2e-003 -4.94 0.0 107 481 294 1070 0.22245 3.0e-005 240 3 M5883_1.02 TBX20 TCACACSTTCACACCT 3.7e-003 5.0e-006 -12.21 0.0 95 485 402 1594 0.19588 2.1e-008 242 3 M5962_1.02 ZBTB7C NTCGGTGGTCGY 5.3e0000 7.0e-003 -4.96 0.0 141 489 910 2816 0.28834 2.9e-005 244 3 M5977_1.02 ZNF740 GTGGGGGGGK 4.5e-001 5.9e-004 -7.43 0.0 259 491 1573 2754 0.52749 2.4e-006 245 3 M5981_1.02 ZSCAN4 TTTTCAGKGTGTGCA 3.2e-003 4.2e-006 -12.38 0.0 100 486 379 1418 0.20576 1.7e-008 242 3 M6139_1.02 AHR KCACGCRAH 7.7e-005 1.0e-007 -16.10 0.0 60 492 437 2692 0.12195 4.2e-010 245 3 M6150_1.02 ARNT2 GYSYSCCACGNC 4.4e0000 5.8e-003 -5.14 0.0 457 489 2770 2908 0.93456 2.4e-005 244 3 M6151_1.02 ARNT BYRCGTGC 1.1e-002 1.4e-005 -11.17 0.0 111 493 664 2450 0.22515 5.7e-008 246 3 M6180_1.02 CREB1 RTGACGTMA 7.0e0000 9.3e-003 -4.68 0.0 48 492 306 2511 0.09756 3.8e-005 245 3 M6191_1.02 E2F2 GGCGCGAAAC 9.1e0000 1.2e-002 -4.42 0.0 201 491 990 2198 0.40937 4.9e-005 245 3 M6199_1.02 EGR2 DGVGTGGGCGG 4.8e-011 6.3e-014 -30.39 0.0 276 490 1805 2828 0.56327 2.6e-016 244 3 M6200_1.02 EGR3 WGAGTGGGYGT 5.0e-018 6.7e-021 -46.46 0.0 112 490 859 2766 0.22857 2.7e-023 244 3 M6201_1.02 EGR4 GGSGGYRGGGM 5.6e-002 7.4e-005 -9.51 0.0 270 490 1547 2578 0.55102 3.0e-007 244 3 M6210_1.02 ENO1 YDSMCACRTGSYB 1.0e-003 1.4e-006 -13.51 0.0 68 488 492 2757 0.13934 5.6e-009 243 3 M6212_1.02 EPAS1 CMCACGYAYDCAC 4.6e-013 6.2e-016 -35.02 0.0 108 488 804 2750 0.22131 2.5e-018 243 3 M6264_1.02 GLI1 BTGGGTGGTCY 9.0e0000 1.2e-002 -4.43 0.0 486 490 2721 2727 0.99184 4.9e-005 244 3 M6265_1.02 GLI2 GTGGGTGGTCY 1.5e-003 1.9e-006 -13.15 0.0 236 490 1146 2110 0.48163 8.0e-009 244 3 M6266_1.02 GLI3 BTGGGTGGTCY 3.9e0000 5.2e-003 -5.26 0.0 192 490 1120 2597 0.39184 2.1e-005 244 3 M6275_1.02 HIF1A SBSTACGTGCSB 7.6e-011 1.0e-013 -29.93 0.0 139 489 891 2481 0.28425 4.1e-016 244 3 M6322_1.02 KLF1 CAGGGTGKGGC 2.6e0000 3.5e-003 -5.65 0.0 270 490 1674 2837 0.55102 1.4e-005 244 3 M6323_1.02 KLF3 HRCYWGGGTGKGGCT 7.7e-002 1.0e-004 -9.18 0.0 102 486 642 2564 0.20988 4.2e-007 242 3 M6324_1.02 KLF4 DGGGYGKGGC 1.1e-004 1.4e-007 -15.75 0.0 263 491 1712 2892 0.53564 5.9e-010 245 3 M6326_1.02 KLF8 CMGGGKGTG 1.0e-006 1.4e-009 -20.42 0.0 110 492 773 2770 0.22358 5.5e-012 245 3 M6352_1.02 MYCN CCACGTGS 7.0e-002 9.3e-005 -9.29 0.0 179 493 1040 2531 0.36308 3.8e-007 246 3 M6442_1.02 PURA CCMBGCCCNCCMMYWCC 2.1e0000 2.8e-003 -5.87 0.0 254 484 1671 2965 0.52479 1.2e-005 241 3 M6456_1.02 RREB1 DKGKKKGKGGKTGKTTKGGGKT 5.0e-003 6.6e-006 -11.92 0.0 133 479 804 2454 0.27766 2.8e-008 239 3 M6482_1.02 SP3 VGVVGGGGGCGGGGCBRGSS 3.2e-004 4.2e-007 -14.67 0.0 185 481 1213 2757 0.38462 1.8e-009 240 3 M6535_1.02 WT1 GMGGGGGCGKGGG 6.9e-009 9.1e-012 -25.42 0.0 98 488 732 2825 0.20082 3.7e-014 243 3 M6540_1.02 ZBTB4 CAATRGCGDTKGYGR 2.4e0000 3.2e-003 -5.76 0.0 280 486 1620 2627 0.57613 1.3e-005 242 3 M6553_1.02 ZNF219 GDGGGGGGYGGA 7.0e-007 9.2e-010 -20.80 0.0 153 489 1051 2810 0.31288 3.8e-012 244 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).