# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 CSCSCCCCSGCCMCGCCCCCNS MEME-1 CSCSCCCCSGCCMCGCCCCCNS 1.3e-037 1.8e-040 -91.52 0.0 183 479 385 579 0.38205 7.5e-043 239 1 YBSYSATTGGCY MEME-2 YBSYSATTGGCY 3.2e-033 4.3e-036 -81.44 0.0 109 489 178 318 0.22290 1.7e-038 244 1 VGVWGGRGGCGKGGCB MEME-4 VGVWGGRGGCGKGGCB 3.3e-018 4.5e-021 -46.86 0.0 165 485 275 491 0.34021 1.8e-023 242 1 TGACGTCAYHGRVGNG MEME-6 TGACGTCAYHGRVGNG 3.2e0000 4.3e-003 -5.45 0.0 143 485 52 106 0.29485 1.8e-005 242 2 ATTGGY DREME-1 ATTGGC 9.4e-028 1.2e-030 -68.86 0.0 109 495 161 298 0.22020 5.1e-033 247 2 CMCRCCCC DREME-2 CMCGCCCC 4.6e-024 6.1e-027 -60.36 0.0 175 493 284 465 0.35497 2.5e-029 246 2 CCSCGCCY DREME-3 CCSCGCCY 1.7e-010 2.3e-013 -29.11 0.0 161 493 226 443 0.32657 9.3e-016 246 2 ACGTSA DREME-4 ACGTSA 2.9e-006 3.9e-009 -19.37 0.0 135 495 95 188 0.27273 1.6e-011 247 2 GGGCGTK DREME-5 GGGCGTG 7.7e-011 1.0e-013 -29.91 0.0 80 494 95 255 0.16194 4.2e-016 246 2 TGABTCA DREME-6 TGASTCA 4.8e-002 6.5e-005 -9.65 0.0 82 494 32 76 0.16599 2.6e-007 246 3 M0189_1.02 (ID2)_(Mus_musculus)_(DBD_0.98) RCACGTGR 8.4e0000 1.1e-002 -4.49 0.0 167 493 200 470 0.33874 4.6e-005 246 3 M0212_1.02 (TCFL5)_(Mus_musculus)_(DBD_1.00) NBCDCGHGVN 7.0e-001 9.4e-004 -6.97 0.0 143 491 186 480 0.29124 3.8e-006 245 3 M0405_1.02 (KLF7)_(Mus_musculus)_(DBD_1.00) DGGGCGKGGY 6.1e-032 8.1e-035 -78.50 0.0 163 491 351 598 0.33198 3.3e-037 245 3 M0443_1.02 (KLF12)_(Mus_musculus)_(DBD_1.00) DGGGCGKGGY 1.2e-025 1.5e-028 -64.04 0.0 161 491 334 598 0.32790 6.3e-031 245 3 M1871_1.02 (KLF2)_(Mus_musculus)_(DBD_0.95) DGGGYGKGGC 1.4e-029 1.9e-032 -73.02 0.0 155 491 333 594 0.31568 7.9e-035 245 3 M1890_1.02 NFYA AGVSYKCTGATTGGYBSR 2.3e-012 3.1e-015 -33.41 0.0 211 483 287 451 0.43685 1.3e-017 241 3 M1906_1.02 SP1 GGGGGMGGGGC 1.8e-015 2.4e-018 -40.57 0.0 160 490 304 594 0.32653 9.9e-021 244 3 M1917_1.02 USF1 GGTCACRTGRB 1.1e-001 1.4e-004 -8.87 0.0 126 490 162 448 0.25714 5.8e-007 244 3 M2301_1.02 NFYB VHMYBRRCCAATCAG 1.7e-017 2.3e-020 -45.24 0.0 110 486 207 484 0.22634 9.3e-023 242 3 M2314_1.02 SP2 SSSVRGRGGCGGGRC 5.2e-014 7.0e-017 -37.20 0.0 214 486 369 592 0.44033 2.9e-019 242 3 M2387_1.02 SREBF1 RTGGGGTGAB 3.3e0000 4.4e-003 -5.42 0.0 129 491 177 511 0.26273 1.8e-005 245 3 M2391_1.02 KLF5 DGGGHGGGGC 1.9e-018 2.6e-021 -47.41 0.0 161 491 314 596 0.32790 1.1e-023 245 3 M4427_1.02 CTCF NYGGCCASCAGRKGGCRSYVB 2.8e0000 3.8e-003 -5.58 0.0 70 480 105 483 0.14583 1.6e-005 239 3 M4451_1.02 ATF3 GGTCACGTGRS 9.9e-002 1.3e-004 -8.93 0.0 126 490 162 445 0.25714 5.4e-007 244 3 M4459_1.02 EGR1 SBGCGKGGGCGGVGGSGSGS 5.5e-012 7.3e-015 -32.55 0.0 81 481 179 573 0.16840 3.0e-017 240 3 M4473_1.02 PBX3 NBCRGCCAATSRGVR 5.0e-016 6.7e-019 -41.84 0.0 134 486 257 553 0.27572 2.8e-021 242 3 M4481_1.02 USF2 GGTCACGTGRSSSSV 5.1e-003 6.7e-006 -11.91 0.0 172 486 196 401 0.35391 2.8e-008 242 3 M4612_1.02 CTCFL CCRSCAGGGGGCGCY 6.2e-001 8.3e-004 -7.10 0.0 244 486 316 526 0.50206 3.4e-006 242 3 M4640_1.02 ZBTB7A GGGSRRGGGKCBSBG 2.5e-006 3.3e-009 -19.53 0.0 102 486 192 581 0.20988 1.4e-011 242 3 M4680_1.02 BACH1 GTCACGTG 1.9e-004 2.6e-007 -15.16 0.0 127 493 188 493 0.25761 1.1e-009 246 3 M5209_1.02 (SP5)_(Drosophila_melanogaster)_(DBD_0.93) GKGGGCGKRKC 3.4e-025 4.6e-028 -62.95 0.0 162 490 332 593 0.33061 1.9e-030 244 3 M5293_1.02 ATF7 BKATGACGTCATHN 2.0e0000 2.6e-003 -5.94 0.0 141 487 98 232 0.28953 1.1e-005 243 3 M5591_1.02 KLF13 CAAAAAGGGGCGTGKCAY 1.6e-010 2.1e-013 -29.19 0.0 181 483 238 418 0.37474 8.8e-016 241 3 M5592_1.02 KLF14 ARGKGGGCGTGGYM 9.3e-037 1.2e-039 -89.59 0.0 151 487 338 579 0.31006 5.1e-042 243 3 M5593_1.02 KLF16 GGGGGCGTGKC 5.5e-040 7.3e-043 -97.02 0.0 154 490 355 596 0.31429 3.0e-045 244 3 M5632_1.02 MLX RTCACGTGAT 1.9e-001 2.5e-004 -8.30 0.0 127 491 119 310 0.25866 1.0e-006 245 3 M5856_1.02 SP8 RGKGGGCGTGGY 8.5e-034 1.1e-036 -82.77 0.0 157 489 347 596 0.32106 4.6e-039 244 3 M5977_1.02 ZNF740 GTGGGGGGGK 5.8e-006 7.8e-009 -18.67 0.0 153 491 254 575 0.31161 3.2e-011 245 3 M6123_1.02 (ZNF281)_(Mus_musculus)_(DBD_1.00) GRGKKGGGGGAGGGG 8.7e-003 1.2e-005 -11.36 0.0 154 486 244 576 0.31687 4.8e-008 242 3 M6155_1.02 ATF6 GBGSTGACGTGG 2.6e0000 3.5e-003 -5.65 0.0 283 489 283 416 0.57873 1.4e-005 244 3 M6174_1.02 CEBPZ AGCCAATSAGH 1.3e-020 1.7e-023 -52.43 0.0 138 490 247 486 0.28163 7.0e-026 244 3 M6180_1.02 CREB1 RTGACGTMA 7.2e0000 9.6e-003 -4.64 0.0 194 492 253 527 0.39431 3.9e-005 245 3 M6199_1.02 EGR2 DGVGTGGGCGG 2.8e-005 3.8e-008 -17.09 0.0 144 490 244 585 0.29388 1.5e-010 244 3 M6200_1.02 EGR3 WGAGTGGGYGT 2.5e-004 3.3e-007 -14.92 0.0 164 490 259 567 0.33469 1.4e-009 244 3 M6201_1.02 EGR4 GGSGGYRGGGM 1.1e-009 1.5e-012 -27.21 0.0 212 490 341 575 0.43265 6.2e-015 244 3 M6240_1.02 FOXI1 RRCCAATCAVAR 1.8e-013 2.4e-016 -35.96 0.0 117 489 197 462 0.23926 9.9e-019 244 3 M6275_1.02 HIF1A SBSTACGTGCSB 7.0e-001 9.4e-004 -6.97 0.0 109 489 157 505 0.22290 3.8e-006 244 3 M6306_1.02 INSM1 TGTMAGGGGGCR 9.7e0000 1.3e-002 -4.34 0.0 197 489 236 481 0.40286 5.4e-005 244 3 M6321_1.02 KLF15 RSMKGGGAGDKGGGGSS 2.8e0000 3.8e-003 -5.58 0.0 278 484 387 587 0.57438 1.6e-005 241 3 M6322_1.02 KLF1 CAGGGTGKGGC 2.7e-002 3.7e-005 -10.21 0.0 104 490 177 582 0.21224 1.5e-007 244 3 M6324_1.02 KLF4 DGGGYGKGGC 8.4e-025 1.1e-027 -62.05 0.0 155 491 322 594 0.31568 4.6e-030 245 3 M6325_1.02 KLF6 GGGGGCKG 2.8e-005 3.8e-008 -17.10 0.0 163 493 267 585 0.33063 1.5e-010 246 3 M6326_1.02 KLF8 CMGGGKGTG 1.7e-001 2.3e-004 -8.39 0.0 76 492 130 559 0.15447 9.2e-007 245 3 M6373_1.02 NFYC YAGCCAATSAGVGS 2.3e-017 3.0e-020 -44.94 0.0 213 487 352 545 0.43737 1.3e-022 243 3 M6482_1.02 SP3 SGVVGGGGGCGGGGCBRGSS 4.6e-011 6.2e-014 -30.41 0.0 155 481 284 586 0.32225 2.6e-016 240 3 M6483_1.02 SP4 GSGGSCRGGGGSGGGGSGGSSSSG 3.2e-005 4.3e-008 -16.97 0.0 273 477 379 538 0.57233 1.8e-010 238 3 M6518_1.02 TFEB RGTCACGTG 3.1e-003 4.1e-006 -12.40 0.0 178 492 180 356 0.36179 1.7e-008 245 3 M6535_1.02 WT1 GMGGGGGCGKGGG 8.5e-015 1.1e-017 -39.02 0.0 130 488 259 586 0.26639 4.7e-020 243 3 M6537_1.02 YBX1 BSKGATTSSCY 1.1e-008 1.4e-011 -24.98 0.0 116 490 223 596 0.23673 5.8e-014 244 3 M6539_1.02 ZBTB7B CGGVGRRGGGGMGSRGGSGGGH 5.2e-001 7.0e-004 -7.26 0.0 93 479 153 558 0.19415 2.9e-006 239 3 M6552_1.02 ZNF148 KGVGKGGGGGMGGGG 2.2e-003 2.9e-006 -12.76 0.0 184 486 291 591 0.37860 1.2e-008 242 3 M6553_1.02 ZNF219 GDGGGGGGYGGA 1.4e-003 1.8e-006 -13.20 0.0 87 489 160 583 0.17791 7.6e-009 244 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).