# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 SCCTCCC MEME-1 SCCTCCC 1.9e0000 2.5e-003 -5.97 0.0 310 494 411 577 0.62753 1.0e-005 246 2 CYTCCY DREME-1 CCTCCC 1.8e0000 2.5e-003 -6.01 0.0 311 495 422 593 0.62828 1.0e-005 247 2 GACCCCW DREME-2 GACCCCW 1.1e-001 1.5e-004 -8.82 0.0 78 494 55 182 0.15789 6.0e-007 246 3 M0422_1.02 (ZIC5)_(Mus_musculus)_(DBD_0.99) SYRGGGGGTM 2.3e-008 3.2e-011 -24.18 0.0 181 491 309 599 0.36864 1.3e-013 245 3 M4612_1.02 CTCFL CCRSCAGGGGGCGCY 8.8e-006 1.2e-008 -18.24 0.0 198 486 305 560 0.40741 4.9e-011 242 3 M4640_1.02 ZBTB7A GGGSRRGGGKCBSBG 3.5e-001 4.7e-004 -7.66 0.0 98 486 169 600 0.20165 1.9e-006 242 3 M5490_1.02 GLIS1 GCDTCGTGGGGGGTCK 2.4e-003 3.3e-006 -12.62 0.0 129 485 77 163 0.26598 1.4e-008 242 3 M5491_1.02 GLIS2 CDYYGCGGGGGGTC 3.4e-013 4.6e-016 -35.31 0.0 121 487 222 526 0.24846 1.9e-018 243 3 M5965_1.02 ZIC4 DCDCMGCGGGGGGYC 1.2e-013 1.6e-016 -36.37 0.0 128 486 251 578 0.26337 6.6e-019 242 3 M5977_1.02 ZNF740 GTGGGGGGGK 2.5e-001 3.4e-004 -7.98 0.0 285 491 394 583 0.58045 1.4e-006 245 3 M6267_1.02 GLIS3 GYGGGGGGTM 4.4e-012 5.9e-015 -32.76 0.0 125 491 246 594 0.25458 2.4e-017 245 3 M6275_1.02 HIF1A SBSTACGTGCSB 6.1e0000 8.2e-003 -4.80 0.0 281 489 332 501 0.57464 3.4e-005 244 3 M6326_1.02 KLF8 CMGGGKGTG 3.1e-001 4.2e-004 -7.79 0.0 198 492 289 580 0.40244 1.7e-006 245 3 M6422_1.02 PLAGL1 CRGGGGGCCC 2.0e-017 2.7e-020 -45.08 0.0 145 491 287 590 0.29532 1.1e-022 245 3 M6548_1.02 ZIC1 KGGGWGGTS 1.5e-004 2.1e-007 -15.38 0.0 270 492 402 599 0.54878 8.5e-010 245 3 M6549_1.02 ZIC2 KGGGTGGTC 1.2e0000 1.7e-003 -6.39 0.0 176 492 266 598 0.35772 6.9e-006 245 3 M6550_1.02 ZIC3 BGGGTGGYC 2.0e0000 2.7e-003 -5.93 0.0 174 492 262 597 0.35366 1.1e-005 245 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).