# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 GDGTGGGTGGRTGDGTGKGT MEME-1 GDGTGGGTGGRTGDGTGKGT 5.6e-025 7.6e-028 -62.45 0.0 165 481 341 597 0.34304 3.1e-030 240 1 CACCCACMCACM MEME-2 CACCCACMCACM 2.3e-025 3.0e-028 -63.36 0.0 253 489 396 519 0.51738 1.2e-030 244 1 YCCACCCACHCMYCCA MEME-3 YCCACCCACHCMYCCA 6.4e-037 8.6e-040 -89.95 0.0 165 485 367 599 0.34021 3.6e-042 242 2 CDCCCAC DREME-1 CACCCAC 3.7e-029 5.0e-032 -72.08 0.0 254 494 420 547 0.51417 2.0e-034 246 2 ATCYACCY DREME-2 ATCCACCC 2.8e-001 3.8e-004 -7.87 0.0 211 493 112 187 0.42799 1.5e-006 246 2 CCWCCTAC DREME-4 CCWCCTAC 2.9e-003 3.9e-006 -12.45 0.0 155 493 80 150 0.31440 1.6e-008 246 2 AGGAGGMG DREME-6 AGGAGGAG 3.2e-002 4.3e-005 -10.06 0.0 75 493 35 95 0.15213 1.7e-007 246 2 CTKCCCAC DREME-8 CTKCCCAC 1.2e0000 1.6e-003 -6.41 0.0 253 493 104 151 0.51318 6.7e-006 246 3 M0405_1.02 (KLF7)_(Mus_musculus)_(DBD_1.00) DGGGCGKGGY 4.8e-009 6.5e-012 -25.77 0.0 213 491 352 598 0.43381 2.6e-014 245 3 M0443_1.02 (KLF12)_(Mus_musculus)_(DBD_1.00) DGGGYGKGKY 4.9e-011 6.6e-014 -30.35 0.0 115 491 230 599 0.23422 2.7e-016 245 3 M1871_1.02 (KLF2)_(Mus_musculus)_(DBD_0.95) DGGGYGKGGC 2.0e-004 2.6e-007 -15.15 0.0 257 491 384 594 0.52342 1.1e-009 245 3 M1950_1.02 ZNF354C GTGGAK 5.0e-003 6.7e-006 -11.91 0.0 301 495 427 597 0.60808 2.7e-008 247 3 M2310_1.02 RUNX2 MAAACCACARAMMMM 5.8e-006 7.8e-009 -18.67 0.0 276 486 401 572 0.56790 3.2e-011 242 3 M2391_1.02 KLF5 DGGGHGGGGC 2.1e-001 2.8e-004 -8.18 0.0 259 491 374 600 0.52749 1.1e-006 245 3 M4459_1.02 EGR1 SBGCGKGGGCGGVGGSGSGG 3.3e-026 4.5e-029 -65.28 0.0 167 481 347 598 0.34719 1.9e-031 240 3 M4604_1.02 ZNF263 RRGGAGGASGVVGRGGRGGRG 1.8e0000 2.4e-003 -6.02 0.0 258 480 356 568 0.53750 1.0e-005 239 3 M5209_1.02 (SP5)_(Drosophila_melanogaster)_(DBD_0.93) GKGGGCGKRKC 4.8e-014 6.4e-017 -37.28 0.0 134 490 265 595 0.27347 2.6e-019 244 3 M5487_1.02 GCM2 BATGCGGGTR 9.8e-006 1.3e-008 -18.15 0.0 183 491 291 576 0.37271 5.4e-011 245 3 M5592_1.02 KLF14 ARGKGGGCGTGGYM 6.5e-004 8.7e-007 -13.96 0.0 109 487 177 530 0.22382 3.6e-009 243 3 M5593_1.02 KLF16 GGGGGCGTGKC 2.5e-013 3.4e-016 -35.62 0.0 252 490 413 597 0.51429 1.4e-018 244 3 M5628_1.02 MGA AGGTGTGA 1.3e-003 1.8e-006 -13.26 0.0 187 493 285 574 0.37931 7.1e-009 246 3 M5856_1.02 SP8 RGKGGGCGTGGY 4.4e-015 5.9e-018 -39.66 0.0 251 489 417 596 0.51329 2.4e-020 244 3 M5875_1.02 TBX1 AGGTGTGAAAAAAGGTGTGA 6.8e-001 9.1e-004 -7.00 0.0 209 481 192 345 0.43451 3.8e-006 240 3 M5883_1.02 TBX20 TCACACSTTCACACCT 4.7e-013 6.3e-016 -34.99 0.0 261 485 326 441 0.53814 2.6e-018 242 3 M5896_1.02 TBX4 AGGTGTGA 1.7e0000 2.3e-003 -6.08 0.0 133 493 198 562 0.26978 9.3e-006 246 3 M5962_1.02 ZBTB7C NTCGGTGGTCGY 2.8e-004 3.7e-007 -14.80 0.0 137 489 232 588 0.28016 1.5e-009 244 3 M5974_1.02 ZNF524 GGGTTCRAGGGT 5.5e-005 7.3e-008 -16.43 0.0 151 489 226 513 0.30879 3.0e-010 244 3 M5977_1.02 ZNF740 GTGGGGGGGK 1.6e-009 2.1e-012 -26.89 0.0 327 491 481 595 0.66599 8.5e-015 245 3 M5981_1.02 ZSCAN4 TTTTCAGKGTGTGCA 1.6e-001 2.2e-004 -8.43 0.0 192 486 196 379 0.39506 9.0e-007 242 3 M6123_1.02 (ZNF281)_(Mus_musculus)_(DBD_1.00) GRGKTGGGGGAGGGG 4.5e-008 6.1e-011 -23.52 0.0 256 486 395 586 0.52675 2.5e-013 242 3 M6139_1.02 AHR KCACGCRAH 5.4e0000 7.3e-003 -4.92 0.0 282 492 352 534 0.57317 3.0e-005 245 3 M6150_1.02 ARNT2 GYSYSCCACGNC 1.0e-006 1.4e-009 -20.40 0.0 141 489 250 596 0.28834 5.7e-012 244 3 M6199_1.02 EGR2 DGVGTGGGCGG 3.9e-030 5.3e-033 -74.32 0.0 150 490 330 599 0.30612 2.2e-035 244 3 M6200_1.02 EGR3 WGAGTGGGYGT 2.7e-023 3.6e-026 -58.60 0.0 174 490 342 591 0.35510 1.5e-028 244 3 M6212_1.02 EPAS1 CMCACGYAYDCAC 1.8e-019 2.4e-022 -49.77 0.0 234 488 406 590 0.47951 1.0e-024 243 3 M6264_1.02 GLI1 BTGGGTGGTCY 2.5e-002 3.3e-005 -10.32 0.0 264 490 374 579 0.53878 1.4e-007 244 3 M6265_1.02 GLI2 GTGGGTGGTCY 2.1e-003 2.8e-006 -12.78 0.0 252 490 343 541 0.51429 1.2e-008 244 3 M6266_1.02 GLI3 BTGGGTGGTCY 1.5e-007 2.0e-010 -22.36 0.0 188 490 306 577 0.38367 8.0e-013 244 3 M6267_1.02 GLIS3 GYGGGGGGTM 3.4e-002 4.6e-005 -9.98 0.0 323 491 447 592 0.65784 1.9e-007 245 3 M6275_1.02 HIF1A SBSTACGTGCSB 3.5e-002 4.7e-005 -9.96 0.0 233 489 301 511 0.47648 1.9e-007 244 3 M6322_1.02 KLF1 CAGGGTGKGGC 6.1e-004 8.3e-007 -14.01 0.0 262 490 387 593 0.53469 3.4e-009 244 3 M6323_1.02 KLF3 HRCYWGGGTGKGGCT 9.8e-008 1.3e-010 -22.75 0.0 260 486 392 575 0.53498 5.4e-013 242 3 M6324_1.02 KLF4 DGGGYGKGGC 9.6e-002 1.3e-004 -8.96 0.0 259 491 373 595 0.52749 5.3e-007 245 3 M6326_1.02 KLF8 CAGGGKGTG 1.6e-002 2.1e-005 -10.78 0.0 148 492 231 570 0.30081 8.5e-008 245 3 M6379_1.02 NKX3-2 VRYTAAGTGGV 5.5e0000 7.4e-003 -4.90 0.0 314 490 416 578 0.64082 3.1e-005 244 3 M6416_1.02 CBFB YYTGTGGTYDB 4.3e-003 5.8e-006 -12.06 0.0 296 490 419 587 0.60408 2.4e-008 244 3 M6442_1.02 PURA CCMBGCCCNCCMMYWCC 3.5e-009 4.7e-012 -26.08 0.0 262 484 416 600 0.54132 1.9e-014 241 3 M6456_1.02 RREB1 DKGKKKGKGGKTGKTTKGGGKT 3.1e-021 4.2e-024 -53.83 0.0 275 479 447 569 0.57411 1.8e-026 239 3 M6459_1.02 RUNX3 AACCRCAAAMCCCV 1.3e-003 1.8e-006 -13.25 0.0 187 487 269 531 0.38398 7.3e-009 243 3 M6482_1.02 SP3 VGVVGGGGGCGGGGCBRGSS 5.2e-002 7.0e-005 -9.56 0.0 259 481 378 589 0.53846 2.9e-007 240 3 M6505_1.02 TBX5 AGGTGTGA 1.2e0000 1.6e-003 -6.42 0.0 225 493 324 593 0.45639 6.6e-006 246 3 M6535_1.02 WT1 GMGGGGGCGKGGG 1.7e-027 2.3e-030 -68.23 0.0 152 488 328 600 0.31148 9.6e-033 243 3 M6539_1.02 ZBTB7B CGGVGRRGGGGMGSRGGSGGGH 1.5e-004 2.0e-007 -15.45 0.0 243 479 329 513 0.50731 8.2e-010 239 3 M6540_1.02 ZBTB4 CAATRGYGDTKGYGR 2.0e0000 2.7e-003 -5.91 0.0 236 486 310 537 0.48560 1.1e-005 242 3 M6548_1.02 ZIC1 KGGGWGGTV 5.9e0000 7.9e-003 -4.84 0.0 186 492 274 598 0.37805 3.2e-005 245 3 M6550_1.02 ZIC3 BGGGTGGYC 1.1e0000 1.5e-003 -6.48 0.0 204 492 300 595 0.41463 6.2e-006 245 3 M6552_1.02 ZNF148 KGVGKGGGGGAGGGG 5.9e-011 7.9e-014 -30.16 0.0 256 486 411 595 0.52675 3.3e-016 242 3 M6553_1.02 ZNF219 GDGGGGGGYGGA 4.6e-010 6.2e-013 -28.12 0.0 165 489 294 596 0.33742 2.5e-015 244 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).