# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 DGCTTTCYAGGAAW MEME-1 DGCTTTCYAGGAAW 2.0e-071 2.6e-074 -169.42 0.0 67 187 415 559 0.35829 2.8e-076 93 2 TCYWRGAA DREME-1 TCYWRGAA 7.3e-048 9.8e-051 -115.15 0.0 71 193 248 313 0.36788 1.0e-052 96 2 CTVGAAA DREME-2 CTRGAAA 3.7e-023 5.0e-026 -58.26 0.0 70 194 173 245 0.36082 5.2e-028 96 2 CRAGGAA DREME-5 CRAGGAA 4.0e0000 5.5e-003 -5.21 0.0 70 194 44 75 0.36082 5.7e-005 96 3 M0433_1.02 (ZBTB12)_(Mus_musculus)_(DBD_1.00) NYCTAGAACN 1.9e-002 2.5e-005 -10.58 0.0 71 191 241 498 0.37173 2.7e-007 95 3 M1955_1.02 STAT1 TTTCYRGGAAA 2.7e-045 3.6e-048 -109.25 0.0 68 190 356 525 0.35789 3.8e-050 94 3 M4444_1.02 RELA DGGGRMTTTCCMVN 1.9e0000 2.6e-003 -5.96 0.0 83 187 184 331 0.44385 2.8e-005 93 3 M4478_1.02 STAT3 SHBVTSAYTTCYRGKAAATR 4.7e-020 6.3e-023 -51.11 0.0 61 181 257 447 0.33702 7.0e-025 90 3 M5292_1.02 ATF4 RKATGAYGCAATM 5.4e0000 7.2e-003 -4.93 0.0 154 188 244 270 0.81915 7.8e-005 93 3 M5303_1.02 BCL6B TGCTTTCTAGGAATTCM 4.5e-041 6.1e-044 -99.51 0.0 72 184 232 290 0.39130 6.7e-046 91 3 M5567_1.02 HSF4 GAANVTTCTAGAA 9.6e-002 1.3e-004 -8.95 0.0 60 188 144 322 0.31915 1.4e-006 93 3 M5568_1.02 HSFY2 TTCGAAHVRTTCGAA 3.7e-002 4.9e-005 -9.91 0.0 46 186 89 224 0.24731 5.4e-007 92 3 M6159_1.02 BCL6 TTCCWRGAAWGYHHWH 5.3e-050 7.2e-053 -120.06 0.0 73 185 411 573 0.39459 7.8e-055 92 3 M6206_1.02 ELF5 AHMAGGAWRTW 5.5e0000 7.4e-003 -4.91 0.0 134 190 407 522 0.70526 7.9e-005 94 3 M6287_1.02 HSF2 VGAABRTTCTAGAA 1.1e-005 1.5e-008 -18.01 0.0 59 187 213 466 0.31551 1.6e-010 93 3 M6361_1.02 NFATC1 AWGGAAWTTTCCD 1.3e0000 1.7e-003 -6.37 0.0 38 188 88 285 0.20213 1.8e-005 93 3 M6363_1.02 NFATC2 RWTTTTCCA 1.7e-002 2.3e-005 -10.67 0.0 54 192 206 537 0.28125 2.4e-007 95 3 M6364_1.02 NFATC3 RDTTTTCCA 1.2e0000 1.6e-003 -6.41 0.0 42 192 159 535 0.21875 1.7e-005 95 3 M6365_1.02 NFATC4 WADTTTTCCH 1.6e-002 2.1e-005 -10.75 0.0 53 191 202 531 0.27749 2.3e-007 95 3 M6448_1.02 RELB RGGGRMTTTCCH 1.9e0000 2.6e-003 -5.96 0.0 99 189 277 447 0.52381 2.7e-005 94 3 M6491_1.02 STAT5A YTTCYVRGAAWT 1.4e-050 1.9e-053 -121.37 0.0 71 189 387 548 0.37566 2.1e-055 94 3 M6492_1.02 STAT5B DTTTCYDGGAATT 2.1e-043 2.9e-046 -104.87 0.0 68 188 337 491 0.36170 3.1e-048 93 3 M6496_1.02 STAT4 TTTCCMAGAAAAV 1.7e-023 2.2e-026 -59.06 0.0 64 188 307 535 0.34043 2.4e-028 93 3 M6497_1.02 STAT6 TTCYYHGGAAWYY 2.6e-023 3.5e-026 -58.61 0.0 66 188 308 525 0.35106 3.8e-028 93 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).