# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 SRTGACGTCAYYNYN MEME-1 SRTGACGTCAYYNYN 2.5e-417 3.4e-420 -965.86 0.0 42 486 500 597 0.08642 1.4e-422 242 1 TGACRTCAY MEME-2 TGACRTCAY 3.9e-388 5.2e-391 -898.66 0.0 38 492 464 585 0.07724 2.1e-393 245 2 TGAYGTMA DREME-1 TGACGTCA 9.1e-390 1.2e-392 -902.41 0.0 33 493 433 544 0.06694 5.0e-395 246 2 KACSTCA DREME-2 GACCTCA 2.6e-242 3.5e-245 -562.87 0.0 34 494 322 483 0.06883 1.4e-247 246 3 M0212_1.02 (TCFL5)_(Mus_musculus)_(DBD_1.00) NBCDCGHGVN 9.3e-003 1.3e-005 -11.28 0.0 113 491 146 421 0.23014 5.2e-008 245 3 M0300_1.02 (ATF2)_(Mus_musculus)_(DBD_1.00) NRTKACGTMA 1.7e-410 2.3e-413 -950.14 0.0 35 491 474 600 0.07128 9.3e-416 245 3 M0305_1.02 (CREB3L2)_(Mus_musculus)_(DBD_1.00) GCCACGTGD 6.8e-039 9.2e-042 -94.49 0.0 44 492 152 485 0.08943 3.8e-044 245 3 M0405_1.02 (KLF7)_(Mus_musculus)_(DBD_1.00) DGGGCGKGGY 2.5e-001 3.3e-004 -8.01 0.0 259 491 353 564 0.52749 1.4e-006 245 3 M0415_1.02 (KLF9)_(Mus_musculus)_(DBD_1.00) VTAACGGN 1.1e0000 1.5e-003 -6.51 0.0 115 493 164 516 0.23327 6.1e-006 246 3 M0424_1.02 (SNAI3)_(Mus_musculus)_(DBD_0.75) NNTGACAKNN 8.8e-055 1.2e-057 -131.08 0.0 31 491 166 600 0.06314 4.8e-060 245 3 M0443_1.02 (KLF12)_(Mus_musculus)_(DBD_1.00) DGGGYGKGKY 3.6e0000 4.8e-003 -5.34 0.0 259 491 349 568 0.52749 2.0e-005 245 3 M0607_1.02 KDM2B NCGNWNNNN 4.6e-004 6.3e-007 -14.28 0.0 34 492 25 94 0.06911 2.6e-009 245 3 M0610_1.02 TET1 NNYRCGYWN 1.7e-006 2.3e-009 -19.88 0.0 42 492 83 443 0.08537 9.4e-012 245 3 M0890_1.02 LHX6 NYAATCAN 4.6e0000 6.3e-003 -5.07 0.0 105 493 159 553 0.21298 2.6e-005 246 3 M0994_1.02 (SIX4)_(Mus_musculus)_(DBD_1.00) NYKAYMCBN 2.8e-001 3.8e-004 -7.87 0.0 34 492 65 508 0.06911 1.6e-006 245 3 M0999_1.02 (NKX6-1)_(Mus_musculus)_(DBD_1.00) NWTAATKRN 4.1e0000 5.6e-003 -5.19 0.0 40 492 72 535 0.08130 2.3e-005 245 3 M1281_1.02 (NAIF1)_(Xenopus_tropicalis)_(DBD_0.71) NNTACGYHN 5.4e-012 7.4e-015 -32.54 0.0 32 492 80 433 0.06504 3.0e-017 245 3 M1432_1.02 NR2E1 NYTGACCTCD 5.9e-182 8.0e-185 -423.90 0.0 35 491 310 598 0.07128 3.3e-187 245 3 M1458_1.02 (RORB)_(Tetraodon_nigroviridis)_(DBD_1.00) NNTGACCTCN 1.3e-098 1.7e-101 -232.02 0.0 33 491 222 588 0.06721 7.0e-104 245 3 M1545_1.02 GMEB1 NNNRCGTNN 4.8e-213 6.4e-216 -495.50 0.0 34 492 317 538 0.06911 2.6e-218 245 3 M1917_1.02 USF1 GGTCACRTGRB 3.9e-009 5.3e-012 -25.96 0.0 50 490 107 486 0.10204 2.2e-014 244 3 M1925_1.02 CEBPA DRTTRTGCAAT 6.1e0000 8.2e-003 -4.80 0.0 68 490 99 482 0.13878 3.4e-005 244 3 M2065_1.02 ESR2 RGGKCANBSTGACCT 4.5e-006 6.1e-009 -18.92 0.0 46 486 101 537 0.09465 2.5e-011 242 3 M2268_1.02 CEBPB KATTGCAYMAY 1.5e-009 2.0e-012 -26.94 0.0 36 490 86 473 0.07347 8.2e-015 244 3 M2270_1.02 DUX4 TAAYYYAATCA 1.4e-004 1.9e-007 -15.46 0.0 72 490 115 448 0.14694 7.9e-010 244 3 M2289_1.02 JUN DDRATGATGTMAT 1.1e-371 1.5e-374 -860.76 0.0 40 488 467 600 0.08197 6.2e-377 243 3 M2301_1.02 NFYB VHMYBRRCCAATCAG 3.5e0000 4.8e-003 -5.34 0.0 86 486 114 445 0.17695 2.0e-005 242 3 M2387_1.02 SREBF1 RTGGGGTGAB 7.8e-100 1.1e-102 -234.81 0.0 37 491 235 595 0.07536 4.3e-105 245 3 M2388_1.02 SREBF2 RTGGGGTGAY 1.1e-103 1.5e-106 -243.66 0.0 33 491 228 595 0.06721 6.2e-109 245 3 M2392_1.02 RFX2 GTYKCCATGGCAACVRVNN 5.5e-001 7.4e-004 -7.21 0.0 160 482 186 424 0.33195 3.1e-006 240 3 M4451_1.02 ATF3 GGTCACGTGRS 3.9e-206 5.3e-209 -479.58 0.0 38 490 333 574 0.07755 2.2e-211 244 3 M4473_1.02 PBX3 NBCDGCCAATSRGVR 9.3e0000 1.3e-002 -4.37 0.0 178 486 245 547 0.36626 5.2e-005 242 3 M4481_1.02 USF2 GGTCACGTGRSSSSV 3.8e-027 5.2e-030 -67.43 0.0 42 486 126 454 0.08642 2.1e-032 242 3 M4511_1.02 RXRA TGACCYYW 2.4e-013 3.3e-016 -35.66 0.0 37 493 110 594 0.07505 1.3e-018 246 3 M4553_1.02 BHLHE40 NGKCACGTGC 7.6e-004 1.0e-006 -13.79 0.0 41 491 81 496 0.08350 4.2e-009 245 3 M4680_1.02 BACH1 GTCACGTG 9.1e-017 1.2e-019 -43.55 0.0 41 493 113 506 0.08316 5.0e-022 246 3 M4930_1.02 (NPAS4)_(Drosophila_melanogaster)_(DBD_0.61) RADTCGTGACT 1.7e-003 2.3e-006 -12.97 0.0 42 490 72 413 0.08571 9.5e-009 244 3 M5234_1.02 (SIM1)_(Drosophila_melanogaster)_(DBD_0.89) GGTCACGTAC 8.7e-014 1.2e-016 -36.68 0.0 43 491 96 408 0.08758 4.8e-019 245 3 M5292_1.02 ATF4 GKATGAYGCAATM 1.2e-221 1.6e-224 -515.31 0.0 38 488 348 579 0.07787 6.6e-227 243 3 M5293_1.02 ATF7 NKATGACGTCATHN 9.8e-422 1.3e-424 -976.02 0.0 33 487 474 599 0.06776 5.4e-427 243 3 M5302_1.02 BATF3 TGATGACGTCATCA 1.2e-360 1.6e-363 -835.37 0.0 33 487 422 556 0.06776 6.6e-366 243 3 M5323_1.02 CREB3 KGRTGACGTCAYNV 1.0e-412 1.4e-415 -955.25 0.0 33 487 467 595 0.06776 5.7e-418 243 3 M5325_1.02 CREB3L1 TGRTGACGTGGCAB 7.2e-027 9.7e-030 -66.81 0.0 39 487 114 410 0.08008 4.0e-032 243 3 M5349_1.02 DUXA NTRAYBTAATCAN 5.7e-045 7.7e-048 -108.49 0.0 42 488 166 527 0.08607 3.2e-050 243 3 M5427_1.02 EVX1 SNTAATYABB 7.9e0000 1.1e-002 -4.54 0.0 75 491 114 523 0.15275 4.4e-005 245 3 M5493_1.02 GMEB2 KTRCGTAA 6.4e-151 8.6e-154 -352.45 0.0 33 493 262 537 0.06694 3.5e-156 246 3 M5581_1.02 IRX2 CDTGTCRTGTWN 2.4e-007 3.3e-010 -21.83 0.0 39 489 94 540 0.07975 1.3e-012 244 3 M5582_1.02 IRX5 SWTGTYRTGTWN 4.3e-005 5.8e-008 -16.67 0.0 39 489 89 556 0.07975 2.4e-010 244 3 M5594_1.02 LBX2 CTBRANSTRATTA 7.7e-003 1.0e-005 -11.47 0.0 44 488 90 554 0.09016 4.3e-008 243 3 M5621_1.02 MEIS3 SCTGTCAH 5.4e-014 7.3e-017 -37.16 0.0 31 493 101 597 0.06288 3.0e-019 246 3 M5623_1.02 MEOX1 VSTAATTANS 9.0e-005 1.2e-007 -15.92 0.0 39 491 83 509 0.07943 5.0e-010 245 3 M5624_1.02 MEOX2 NSTAATTAWN 2.0e-003 2.7e-006 -12.81 0.0 45 491 92 549 0.09165 1.1e-008 245 3 M5632_1.02 MLX RTCACGTGAT 2.2e-075 3.0e-078 -178.50 0.0 43 491 188 441 0.08758 1.2e-080 245 3 M5689_1.02 NRL DWWNTGCTGAC 5.9e-008 8.0e-011 -23.25 0.0 38 490 98 577 0.07755 3.3e-013 244 3 M5702_1.02 PAX1 DKCABTCAWGCGTGACG 9.4e-018 1.3e-020 -45.81 0.0 78 484 115 281 0.16116 5.3e-023 241 3 M5711_1.02 PAX9 KKCASTCAWGCGTGACS 1.2e-011 1.6e-014 -31.78 0.0 42 484 60 210 0.08678 6.5e-017 241 3 M5714_1.02 PHOX2A TAATYYAATTA 4.4e-002 5.9e-005 -9.74 0.0 32 490 59 444 0.06531 2.4e-007 244 3 M5715_1.02 PHOX2B TAATBYAATTA 2.6e-003 3.5e-006 -12.55 0.0 38 490 72 461 0.07755 1.4e-008 244 3 M5746_1.02 POU6F2 WTAATKAGST 1.5e-006 2.0e-009 -20.01 0.0 37 491 82 485 0.07536 8.3e-012 245 3 M5753_1.02 PROX1 YAAGACGYCTTA 1.2e-022 1.6e-025 -57.09 0.0 49 489 112 362 0.10020 6.6e-028 244 3 M5777_1.02 RFX4 NGTWRCCATGGYWACS 9.5e-005 1.3e-007 -15.86 0.0 131 485 148 350 0.27010 5.3e-010 242 3 M5889_1.02 TBX21 GGTGTGAHWTCACACC 3.4e-013 4.6e-016 -35.32 0.0 37 485 71 289 0.07629 1.9e-018 242 3 M5932_1.02 TFEC VTCAYGTGAY 3.1e-006 4.2e-009 -19.30 0.0 43 491 97 540 0.08758 1.7e-011 245 3 M5934_1.02 TGIF2 TGACASCTGTCA 8.1e0000 1.1e-002 -4.51 0.0 381 489 244 279 0.77914 4.5e-005 244 3 M5941_1.02 UNCX NTAATYBAATTAN 1.7e-009 2.3e-012 -26.79 0.0 32 488 85 517 0.06557 9.5e-015 243 3 M5959_1.02 ZBTB49 TTTCGCYTGGCVSGTCA 5.6e0000 7.6e-003 -4.88 0.0 6 484 12 226 0.01240 3.2e-005 241 3 M5998_1.02 (CREB5)_(Mus_musculus)_(DBD_1.00) DRTGACGTCATN 7.3e-422 9.9e-425 -976.30 0.0 37 489 488 600 0.07566 4.1e-427 244 3 M6152_1.02 ATF1 VTGACGTCAV 2.3e-382 3.1e-385 -885.35 0.0 33 491 449 597 0.06721 1.3e-387 245 3 M6155_1.02 ATF6 GBGSTGACGTGG 8.0e-162 1.1e-164 -377.55 0.0 37 489 281 528 0.07566 4.4e-167 244 3 M6162_1.02 ARNTL GRGTCACGTGTYCM 1.8e-014 2.5e-017 -38.24 0.0 39 487 82 340 0.08008 1.0e-019 243 3 M6166_1.02 CDC5L RWTAYRTTAAMWCVC 6.3e-026 8.6e-029 -64.63 0.0 36 486 121 499 0.07407 3.5e-031 242 3 M6171_1.02 CEBPD RRTKDBGCAAT 3.9e-005 5.2e-008 -16.77 0.0 68 490 134 561 0.13878 2.1e-010 244 3 M6172_1.02 CEBPE VAKATTDCGHAA 6.3e-021 8.5e-024 -53.12 0.0 51 489 148 566 0.10429 3.5e-026 244 3 M6173_1.02 CEBPG VAGATTGCAHAAT 2.4e-003 3.2e-006 -12.65 0.0 62 488 110 505 0.12705 1.3e-008 243 3 M6174_1.02 CEBPZ AGCCAATSAGH 9.1e0000 1.2e-002 -4.40 0.0 424 490 420 454 0.86531 5.1e-005 244 3 M6180_1.02 CREB1 RTGACGTMA 1.1e-382 1.5e-385 -886.11 0.0 34 492 453 599 0.06911 6.0e-388 245 3 M6181_1.02 CREM CRVTGACGTCA 3.3e-371 4.4e-374 -859.68 0.0 36 490 452 597 0.07347 1.8e-376 244 3 M6186_1.02 DBP BVTTRCATAAB 8.0e-026 1.1e-028 -64.39 0.0 36 490 125 534 0.07347 4.5e-031 244 3 M6192_1.02 E2F3 SSCGCSAAAC 4.3e0000 5.8e-003 -5.16 0.0 193 491 224 458 0.39308 2.4e-005 245 3 M6197_1.02 E4F1 YGTKACGTC 1.5e-284 2.0e-287 -660.14 0.0 36 492 391 587 0.07317 8.2e-290 245 3 M6216_1.02 ESRRG TGACCTTGA 2.6e-010 3.5e-013 -28.69 0.0 30 492 88 571 0.06098 1.4e-015 245 3 M6224_1.02 ETV7 KCMHCAGGAAGTRACDY 1.6e-001 2.1e-004 -8.47 0.0 42 484 70 445 0.08678 8.7e-007 241 3 M6240_1.02 FOXI1 RRCCAATCAVAR 9.5e0000 1.3e-002 -4.35 0.0 121 489 140 420 0.24744 5.3e-005 244 3 M6275_1.02 HIF1A SBSTACGTGCSB 8.8e0000 1.2e-002 -4.43 0.0 47 489 70 451 0.09611 4.9e-005 244 3 M6277_1.02 HLF SKRTTACRYAAYC 5.2e-179 7.0e-182 -417.13 0.0 34 488 298 569 0.06967 2.9e-184 243 3 M6315_1.02 ISL1 SYTAATR 5.4e-001 7.3e-004 -7.22 0.0 36 494 69 534 0.07287 3.0e-006 246 3 M6331_1.02 MAFB WGCTGACDS 5.8e-033 7.8e-036 -80.83 0.0 36 492 146 597 0.07317 3.2e-038 245 3 M6332_1.02 MAF KTGCTGAC 1.3e-007 1.8e-010 -22.43 0.0 39 493 100 592 0.07911 7.4e-013 246 3 M6333_1.02 MAFG MATGACT 4.9e-129 6.6e-132 -302.05 0.0 36 494 263 598 0.07287 2.7e-134 246 3 M6345_1.02 MITF VKCACATGWY 2.3e-001 3.2e-004 -8.06 0.0 43 491 82 549 0.08758 1.3e-006 245 3 M6359_1.02 NFE2L1 NATGACD 1.4e-117 1.9e-120 -275.64 0.0 36 494 251 598 0.07287 7.9e-123 246 3 M6368_1.02 NFIL3 VKVMVTTACRTAAY 3.6e-148 4.9e-151 -346.10 0.0 39 487 282 556 0.08008 2.0e-153 243 3 M6384_1.02 NR1H4 AGGTCANTGACCYY 9.9e-003 1.3e-005 -11.23 0.0 23 487 53 500 0.04723 5.5e-008 243 3 M6406_1.02 PAX2 RHKCAGTSAYGMGTGAYW 5.4e-008 7.3e-011 -23.34 0.0 57 483 122 528 0.11801 3.0e-013 241 3 M6415_1.02 PDX1 CTAATTACY 5.0e0000 6.7e-003 -5.00 0.0 84 492 111 449 0.17073 2.8e-005 245 3 M6443_1.02 RARA TGACCTB 2.1e-151 2.8e-154 -353.56 0.0 36 494 284 594 0.07287 1.1e-156 246 3 M6445_1.02 RARB BBBBTGACCTS 1.4e-026 1.9e-029 -66.14 0.0 40 490 142 588 0.08163 7.7e-032 244 3 M6453_1.02 RFX3 TYRCCATGGYAACV 2.7e-002 3.6e-005 -10.22 0.0 149 487 151 345 0.30595 1.5e-007 243 3 M6454_1.02 RORA TGACCTAVWTWH 7.9e-007 1.1e-009 -20.65 0.0 31 489 69 442 0.06339 4.4e-012 244 3 M6461_1.02 RXRB YSTGACCTSA 5.1e-110 6.8e-113 -258.27 0.0 35 491 241 594 0.07128 2.8e-115 245 3 M6510_1.02 TEF TGTTTATRTAAMTK 2.9e-099 3.9e-102 -233.49 0.0 33 487 221 577 0.06776 1.6e-104 243 3 M6517_1.02 TFE3 RGTCAYGTGV 2.9e-003 3.9e-006 -12.44 0.0 111 491 180 544 0.22607 1.6e-008 245 3 M6518_1.02 TFEB RGTCACGTG 1.3e-058 1.8e-061 -139.88 0.0 42 492 164 426 0.08537 7.3e-064 245 3 M6519_1.02 TGIF1 MWGSTGACACCTSMCA 1.3e-008 1.7e-011 -24.78 0.0 51 485 123 584 0.10515 7.2e-014 242 3 M6521_1.02 THRA STGACCTSAV 9.9e-056 1.3e-058 -133.26 0.0 31 491 167 595 0.06314 5.5e-061 245 3 M6523_1.02 THRB TGACCTSABSTSRSSYC 1.3e-055 1.7e-058 -133.01 0.0 38 484 181 572 0.07851 7.1e-061 241 3 M6536_1.02 XBP1 GACGTGKCMHWW 2.7e0000 3.7e-003 -5.61 0.0 235 489 226 384 0.48057 1.5e-005 244 3 M6555_1.02 ZNF333 SKATAATGA 2.4e0000 3.2e-003 -5.74 0.0 40 492 63 448 0.08130 1.3e-005 245 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).