# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 2 VGCGGGAR DREME-1 GGCGGGAR 1.0e-130 1.3e-133 -306.00 0.0 87 493 2157 7311 0.17647 5.2e-136 246 2 CACGTG DREME-2 CACGTG 2.3e-062 2.9e-065 -148.60 0.0 117 495 1327 3635 0.23636 1.2e-067 247 2 CAAVATGG DREME-5 CAARATGG 1.9e-009 2.4e-012 -26.75 0.0 135 493 987 2914 0.27383 9.8e-015 246 2 AYGTG DREME-15 ATGTG 3.4e-008 4.3e-011 -23.87 0.0 114 496 3994 15688 0.22984 1.7e-013 247 2 RAACCAGA DREME-18 GAACCAGA 1.2e-008 1.5e-011 -24.94 0.0 95 493 340 1206 0.19270 6.0e-014 246 2 GCRCGCGS DREME-21 GCGCGCGS 3.5e-022 4.5e-025 -56.06 0.0 127 493 1417 4269 0.25761 1.8e-027 246 2 BTTATCA DREME-22 BTTATCA 5.5e-003 7.0e-006 -11.87 0.0 138 494 1046 3239 0.27935 2.8e-008 246 2 CTCTGACA DREME-24 CTCTGACA 3.0e-013 3.9e-016 -35.49 0.0 67 493 171 638 0.13590 1.6e-018 246 2 MTGAGTCA DREME-25 MTGAGTCA 2.1e0000 2.6e-003 -5.95 0.0 267 493 925 1553 0.54158 1.1e-005 246 2 AGATSGAG DREME-37 AGATGGAG 8.1e-018 1.0e-020 -46.03 0.0 99 493 455 1469 0.20081 4.2e-023 246 2 SGCGGGA DREME-40 SGCGGGA 2.8e-099 3.5e-102 -233.60 0.0 72 494 1853 7748 0.14575 1.4e-104 246 2 ATGGCKGC DREME-47 ATGGCKGC 2.5e0000 3.2e-003 -5.74 0.0 67 493 268 1535 0.13590 1.3e-005 246 2 GCTGGGTA DREME-49 GCTGGGTA 3.0e-003 3.8e-006 -12.47 0.0 95 493 152 515 0.19270 1.6e-008 246 2 AGGTCWCA DREME-51 AGGTCTCA 2.2e0000 2.9e-003 -5.86 0.0 177 493 511 1221 0.35903 1.2e-005 246 3 M0177_1.02 (TWIST2)_(Mus_musculus)_(DBD_1.00) NMCATATGTN 6.3e-003 8.1e-006 -11.73 0.0 117 491 4115 16032 0.23829 3.3e-008 245 3 M0178_1.02 (ASCL2)_(Mus_musculus)_(DBD_0.98) NVCAGCTGBN 2.4e-005 3.0e-008 -17.31 0.0 85 491 3966 20883 0.17312 1.2e-010 245 3 M0189_1.02 (ID2)_(Mus_musculus)_(DBD_0.98) RCACGTGR 4.0e-033 5.1e-036 -81.27 0.0 105 493 4577 18080 0.21298 2.1e-038 246 3 M0195_1.02 (TCF23)_(Mus_musculus)_(DBD_0.60) DMCAKMTGKH 5.1e0000 6.5e-003 -5.04 0.0 83 491 3563 19806 0.16904 2.7e-005 245 3 M0196_1.02 (NPAS2)_(Mus_musculus)_(DBD_1.00) NSCACGTGTN 7.0e-028 8.9e-031 -69.19 0.0 117 491 4946 17852 0.23829 3.6e-033 245 3 M0198_1.02 (SOHLH2)_(Mus_musculus)_(DBD_0.84) NRYVCGTGCN 3.0e-012 3.7e-015 -33.22 0.0 85 491 4049 20686 0.17312 1.5e-017 245 3 M0199_1.02 (HES2)_(Mus_musculus)_(DBD_0.83) NNNNGRCACGTGM 1.2e-005 1.5e-008 -18.01 0.0 70 488 3413 21453 0.14344 6.2e-011 243 3 M0211_1.02 (MLXIP)_(Mus_musculus)_(DBD_0.82) BCACGTGK 2.4e-032 3.0e-035 -79.50 0.0 117 493 5103 18342 0.23732 1.2e-037 246 3 M0212_1.02 (TCFL5)_(Mus_musculus)_(DBD_1.00) NBCDCGHGVN 3.9e-068 4.9e-071 -161.89 0.0 115 491 4895 16572 0.23422 2.0e-073 245 3 M0305_1.02 (CREB3L2)_(Mus_musculus)_(DBD_1.00) GCCACGTGD 1.3e-020 1.6e-023 -52.48 0.0 114 492 4233 15831 0.23171 6.6e-026 245 3 M0413_1.02 (ZBTB1)_(Mus_musculus)_(DBD_0.99) NDTGCGKGDN 9.5e-007 1.2e-009 -20.53 0.0 135 491 6130 20691 0.27495 4.9e-012 245 3 M0432_1.02 (ZFP161)_(Mus_musculus)_(DBD_1.00) NNCGYGCHH 4.1e-034 5.2e-037 -83.55 0.0 128 492 4603 14946 0.26016 2.1e-039 245 3 M0609_1.02 DNMT1 NNCCGMNNNN 6.6e-008 8.4e-011 -23.20 0.0 111 491 4220 16916 0.22607 3.4e-013 245 3 M0610_1.02 TET1 NNYRCGYWN 2.3e-001 3.0e-004 -8.12 0.0 84 492 2751 14833 0.17073 1.2e-006 245 3 M1545_1.02 GMEB1 NNNRCGTNN 9.6e-001 1.2e-003 -6.71 0.0 118 492 4203 16505 0.23984 5.0e-006 245 3 M1889_1.02 MAX RRGCACATGK 2.6e-017 3.3e-020 -44.87 0.0 119 491 5061 18513 0.24236 1.3e-022 245 3 M1917_1.02 USF1 GGTCACRTGRB 1.3e-009 1.7e-012 -27.10 0.0 98 490 3925 17556 0.20000 7.0e-015 244 3 M1919_1.02 YY1 CAARATGGCBGC 8.6e-003 1.1e-005 -11.42 0.0 45 489 1980 19148 0.09202 4.5e-008 244 3 M1927_1.02 (MYCL1)_(Mus_musculus)_(DBD_0.66) RCCACGTG 2.4e-036 3.1e-039 -88.67 0.0 113 493 5060 18634 0.22921 1.3e-041 246 3 M2273_1.02 E2F6 RGGCGGGARRV 1.2e-047 1.5e-050 -114.72 0.0 78 490 4258 21450 0.15918 6.2e-053 244 3 M2305_1.02 NRF1 YGCGCABGCGC 1.1e-006 1.4e-009 -20.36 0.0 82 490 2863 15209 0.16735 5.9e-012 244 3 M2323_1.02 ZBTB33 SARVTCTCGCGAGAV 1.0e-012 1.3e-015 -34.26 0.0 176 486 5742 14478 0.36214 5.5e-018 242 3 M4427_1.02 CTCF NYGGCCASCAGRKGGCRSYVB 1.5e-002 2.0e-005 -10.84 0.0 354 480 12912 17101 0.73750 8.2e-008 239 3 M4451_1.02 ATF3 GGTCACGTGRS 8.8e-015 1.1e-017 -39.03 0.0 102 490 3782 15894 0.20816 4.6e-020 244 3 M4454_1.02 BRCA1 ARVTCTCGCGAGAVB 2.7e-004 3.4e-007 -14.89 0.0 260 486 5834 10342 0.53498 1.4e-009 242 3 M4462_1.02 GABPA VVCCGGAAGTG 6.8e-002 8.6e-005 -9.36 0.0 270 490 11629 20463 0.55102 3.5e-007 244 3 M4481_1.02 USF2 GGTCACGTGRSSSSV 9.5e-021 1.2e-023 -52.77 0.0 106 486 3870 15243 0.21811 5.0e-026 242 3 M4522_1.02 ELK4 CCGGAAGYGS 5.6e-001 7.2e-004 -7.24 0.0 241 491 10740 21207 0.49084 2.9e-006 245 3 M4532_1.02 MYC CCACGTGSYY 3.0e-046 3.8e-049 -111.48 0.0 115 491 5485 19532 0.23422 1.6e-051 245 3 M4536_1.02 E2F1 VRRVRGVGCGCGCRS 2.6e-020 3.2e-023 -51.78 0.0 112 486 4622 17503 0.23045 1.3e-025 242 3 M4537_1.02 E2F4 SGCGGGAARWTBVRR 2.6e-085 3.3e-088 -201.44 0.0 66 486 3731 19948 0.13580 1.4e-090 242 3 M4543_1.02 MXI1 VVVVCCACGTG 1.6e-032 2.1e-035 -79.87 0.0 112 490 4933 18336 0.22857 8.5e-038 244 3 M4553_1.02 BHLHE40 NGKCACGTGC 9.6e-023 1.2e-025 -57.36 0.0 133 491 5618 18284 0.27088 5.0e-028 245 3 M4612_1.02 CTCFL CCRSCAGGGGGCGCY 3.5e0000 4.4e-003 -5.42 0.0 182 486 6542 16774 0.37449 1.8e-005 242 3 M4636_1.02 THAP1 YTGCCCDBANYMAAGATGGCG 1.2e-003 1.5e-006 -13.40 0.0 114 480 2596 9902 0.23750 6.3e-009 239 3 M4680_1.02 BACH1 GTCACGTG 7.6e-013 9.7e-016 -34.57 0.0 87 493 3735 18586 0.17647 3.9e-018 246 3 M5234_1.02 (SIM1)_(Drosophila_melanogaster)_(DBD_0.89) GGTCACGTAC 2.4e0000 3.0e-003 -5.79 0.0 129 491 3780 13557 0.26273 1.2e-005 245 3 M5321_1.02 CLOCK AACACGTGTH 1.3e-024 1.6e-027 -61.68 0.0 87 491 3352 15783 0.17719 6.7e-030 245 3 M5323_1.02 CREB3 KGRTGACGTCAYNV 2.9e-001 3.7e-004 -7.89 0.0 211 487 3764 8201 0.43326 1.5e-006 243 3 M5325_1.02 CREB3L1 TGRTGACGTGGCAB 1.1e-004 1.4e-007 -15.81 0.0 85 487 2399 12252 0.17454 5.6e-010 243 3 M5363_1.02 E2F8 TTTCCCGCCAAA 3.2e-028 4.1e-031 -69.96 0.0 77 489 1870 9120 0.15746 1.7e-033 244 3 M5398_1.02 ERF ACCGGAAGTR 1.5e0000 1.9e-003 -6.27 0.0 245 491 10142 19717 0.49898 7.7e-006 245 3 M5420_1.02 ETV1 ACCGGAAGTD 1.2e-001 1.6e-004 -8.76 0.0 277 491 12058 20761 0.56415 6.4e-007 245 3 M5493_1.02 GMEB2 KTRCGTAA 2.9e-001 3.7e-004 -7.90 0.0 143 493 4946 16116 0.29006 1.5e-006 246 3 M5504_1.02 HES5 YGGCACGTGYCR 4.7e-015 6.0e-018 -39.66 0.0 103 489 2186 8685 0.21063 2.4e-020 244 3 M5506_1.02 HES7 YGGCACGTGCCR 1.0e-010 1.3e-013 -29.66 0.0 119 489 1873 6529 0.24335 5.4e-016 244 3 M5509_1.02 HEY1 GRCACGTGBC 5.3e-049 6.7e-052 -117.83 0.0 119 491 4820 16314 0.24236 2.8e-054 245 3 M5627_1.02 MESP1 NVCAGGTGYD 1.9e-002 2.4e-005 -10.62 0.0 91 491 4384 22020 0.18534 1.0e-007 245 3 M5632_1.02 MLX RTCACGTGAT 4.5e-017 5.7e-020 -44.31 0.0 115 491 3261 11978 0.23422 2.3e-022 245 3 M5634_1.02 MNT RVCACGTGVH 5.8e-031 7.3e-034 -76.29 0.0 115 491 4947 18026 0.23422 3.0e-036 245 3 M5932_1.02 TFEC VTCAYGTGAY 2.0e-012 2.5e-015 -33.60 0.0 171 491 7338 19440 0.34827 1.0e-017 245 3 M5955_1.02 YY2 WAATGGCGGWY 2.2e-005 2.8e-008 -17.38 0.0 90 490 3963 19678 0.18367 1.2e-010 244 3 M6139_1.02 AHR KCACGCRAH 6.5e-009 8.2e-012 -25.52 0.0 128 492 5596 19717 0.26016 3.4e-014 245 3 M6151_1.02 ARNT BYRCGTGC 5.9e-036 7.5e-039 -87.78 0.0 115 493 4768 17189 0.23327 3.1e-041 246 3 M6161_1.02 BHLHE41 WSVRKSYCACGTGMHGRRRV 7.9e-002 1.0e-004 -9.21 0.0 87 481 3653 18744 0.18087 4.2e-007 240 3 M6162_1.02 ARNTL GRGTCACGTGTYCM 4.9e-018 6.3e-021 -46.52 0.0 119 487 3602 12746 0.24435 2.6e-023 243 3 M6191_1.02 E2F2 GGCGCGAAAC 1.5e-034 1.9e-037 -84.57 0.0 99 491 4144 17050 0.20163 7.6e-040 245 3 M6192_1.02 E2F3 SSCGCSAAAC 3.9e-032 5.0e-035 -78.99 0.0 97 491 4068 17152 0.19756 2.0e-037 245 3 M6194_1.02 E2F5 SGCGCSAAAH 1.3e-062 1.7e-065 -149.15 0.0 83 491 3612 16266 0.16904 6.8e-068 245 3 M6196_1.02 E2F7 WWDGGCGCGAAAM 4.6e-039 5.8e-042 -94.95 0.0 94 488 2857 11658 0.19262 2.4e-044 243 3 M6208_1.02 ELK3 VMCHGGAARTSC 6.2e-001 7.9e-004 -7.14 0.0 279 489 11909 20315 0.57055 3.3e-006 244 3 M6210_1.02 ENO1 YDSMCACRTGSYB 2.0e-034 2.5e-037 -84.27 0.0 100 488 5174 21386 0.20492 1.0e-039 243 3 M6212_1.02 EPAS1 CMCACGYAYDCAC 2.1e0000 2.6e-003 -5.94 0.0 72 488 3083 19457 0.14754 1.1e-005 243 3 M6221_1.02 ETS2 VMVGGAAGTKS 9.7e-004 1.2e-006 -13.61 0.0 106 490 5227 22509 0.21633 5.0e-009 244 3 M6271_1.02 HES1 KGKCKCGTGBCKB 1.9e-010 2.4e-013 -29.06 0.0 130 488 6268 21573 0.26639 9.9e-016 243 3 M6273_1.02 HEY2 GBBGGCWCGTGGCHTBV 5.5e-006 7.0e-009 -18.77 0.0 56 484 2288 17340 0.11570 2.9e-011 241 3 M6275_1.02 HIF1A SBSTACGTGCSB 5.3e-022 6.7e-025 -55.66 0.0 125 489 5049 17299 0.25562 2.7e-027 244 3 M6276_1.02 HINFP DMSNHMGCGGACGTTV 1.7e0000 2.2e-003 -6.12 0.0 353 485 9827 13201 0.72784 9.1e-006 242 3 M6316_1.02 TCF4 VCAGGTGCD 1.3e0000 1.6e-003 -6.41 0.0 52 492 2313 20060 0.10569 6.7e-006 245 3 M6345_1.02 MITF VKCACATGWY 2.1e-004 2.7e-007 -15.12 0.0 85 491 3839 20292 0.17312 1.1e-009 245 3 M6346_1.02 MLXIPL VCACGVSGKKGBCMCRTGC 8.6e-001 1.1e-003 -6.82 0.0 68 482 2185 14162 0.14108 4.5e-006 240 3 M6352_1.02 MYCN CCACGTGS 2.4e-051 3.1e-054 -123.22 0.0 117 493 5423 18868 0.23732 1.2e-056 246 3 M6354_1.02 MYOD1 RACAGSTGS 2.1e0000 2.6e-003 -5.94 0.0 152 492 7113 22073 0.30894 1.1e-005 245 3 M6358_1.02 NEUROD1 SGGCAGRTGKSC 3.4e-007 4.3e-010 -21.57 0.0 153 489 7149 21333 0.31288 1.8e-012 244 3 M6515_1.02 TFDP1 AWWKRGCGGGAAAY 2.5e-053 3.2e-056 -127.79 0.0 93 487 4192 17439 0.19097 1.3e-058 243 3 M6517_1.02 TFE3 RGTCAYGTGV 1.1e-005 1.4e-008 -18.06 0.0 101 491 4511 20115 0.20570 5.9e-011 245 3 M6518_1.02 TFEB RGTCACGTG 1.2e-016 1.6e-019 -43.31 0.0 100 492 2775 11576 0.20325 6.3e-022 245 3 M6527_1.02 TWIST1 MCCCAGGTGK 7.0e-002 8.9e-005 -9.33 0.0 199 491 7739 18281 0.40530 3.6e-007 245 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).