# WARNING: this file is not sorted! # db id alt consensus E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 WTCAARATGGAGTYACTCWKGT MEME-1 WTCAARATGGAGTYACTCWKGT 1.1e-158 1.4e-161 -370.36 0.0 123 479 655 969 0.25678 6.0e-164 239 2 CAANATGG DREME-1 CAAGATGG 5.1e-045 6.4e-048 -108.67 0.0 265 493 1851 2732 0.53753 2.6e-050 246 2 AAAATDAG DREME-4 AAAATDAG 8.8e-019 1.1e-021 -48.25 0.0 125 493 627 1726 0.25355 4.5e-024 246 2 GCCRCCAY DREME-7 GCCRCCAY 2.6e-013 3.2e-016 -35.67 0.0 285 493 1699 2565 0.57809 1.3e-018 246 2 GGTTCAMR DREME-8 GGTTCAAR 5.5e-017 6.9e-020 -44.12 0.0 95 493 412 1365 0.19270 2.8e-022 246 2 CTSCWGCC DREME-9 CTSCWGCC 3.2e-001 4.1e-004 -7.81 0.0 277 493 2394 4001 0.56187 1.7e-006 246 2 GTAGAGAY DREME-10 GTAGAGAC 6.4e0000 8.0e-003 -4.82 0.0 89 493 217 929 0.18053 3.3e-005 246 2 TGTCAGAR DREME-12 TGTCAGAG 2.1e-034 2.7e-037 -84.21 0.0 109 493 296 650 0.22110 1.1e-039 246 2 AGGTCAGD DREME-13 AGGTCAGG 1.2e-006 1.6e-009 -20.27 0.0 291 493 1048 1555 0.59026 6.4e-012 246 2 CMCAGC DREME-14 CMCAGC 9.9e-001 1.2e-003 -6.69 0.0 117 495 2379 9293 0.23636 5.1e-006 247 2 AGTYRCTC DREME-15 AGTYRCTC 7.7e-053 9.6e-056 -126.68 0.0 113 493 438 933 0.22921 3.9e-058 246 2 GGGTTTCA DREME-19 GGGTTTCA 5.8e-001 7.3e-004 -7.22 0.0 129 493 244 721 0.26166 3.0e-006 246 2 ATGGCG DREME-22 ATGGCG 5.8e-036 7.3e-039 -87.82 0.0 259 495 2127 3331 0.52323 2.9e-041 247 2 CCSAGTAG DREME-23 CCCAGTAG 7.1e-010 8.9e-013 -27.75 0.0 207 493 443 794 0.41988 3.6e-015 246 2 CACDCAC DREME-26 CACACAC 4.8e-011 6.0e-014 -30.44 0.0 188 494 1327 2921 0.38057 2.5e-016 246 2 GCTGAGDC DREME-28 GCTGAGDC 5.7e-008 7.1e-011 -23.36 0.0 157 493 887 2274 0.31846 2.9e-013 246 2 CAGSCATG DREME-30 CAGSCATG 1.1e-006 1.4e-009 -20.40 0.0 133 493 367 995 0.26978 5.6e-012 246 2 AGGCATTS DREME-31 AGGCATTS 1.6e-016 2.0e-019 -43.05 0.0 289 493 545 721 0.58621 8.1e-022 246 2 CCTRGAAA DREME-35 CCTGGAAA 2.7e-002 3.4e-005 -10.30 0.0 287 493 574 859 0.58215 1.4e-007 246 2 AGACAGTG DREME-38 AGACAGTG 2.0e-002 2.5e-005 -10.61 0.0 167 493 200 433 0.33874 1.0e-007 246 2 CNGCAGC DREME-39 CNGCAGC 8.3e0000 1.0e-002 -4.57 0.0 180 494 2265 5816 0.36437 4.2e-005 246 2 AGGCHGAG DREME-41 AGGCHGAG 1.2e-004 1.5e-007 -15.68 0.0 145 493 1028 2972 0.29412 6.3e-010 246 2 STGGGKA DREME-47 STGGGGA 4.0e-009 5.1e-012 -26.01 0.0 120 494 1386 4765 0.24291 2.1e-014 246 2 AATAGGR DREME-50 AATAGGR 7.9e-006 9.9e-009 -18.43 0.0 74 494 259 1167 0.14980 4.0e-011 246 2 CTGTAYC DREME-53 CTGTAYC 2.8e-001 3.5e-004 -7.96 0.0 342 494 840 1110 0.69231 1.4e-006 246 2 GGAGGTTA DREME-55 GGAGGTTA 5.4e0000 6.7e-003 -5.00 0.0 205 493 751 1613 0.41582 2.8e-005 246 2 CAGMACCG DREME-58 CAGMACCG 7.2e0000 9.0e-003 -4.71 0.0 107 493 142 480 0.21704 3.7e-005 246 2 AAGCAGGG DREME-59 AAGCAGGG 5.3e-001 6.7e-004 -7.31 0.0 177 493 279 622 0.35903 2.7e-006 246 2 GGAGTTCM DREME-60 GGAGTTCM 2.6e0000 3.3e-003 -5.72 0.0 245 493 475 833 0.49696 1.3e-005 246 3 M0195_1.02 (TCF23)_(Mus_musculus)_(DBD_0.60) DMCAKMTGKH 1.6e-002 2.0e-005 -10.81 0.0 119 491 2871 10868 0.24236 8.2e-008 245 3 M0433_1.02 (ZBTB12)_(Mus_musculus)_(DBD_1.00) NYCTAGAACN 5.4e0000 6.8e-003 -5.00 0.0 47 491 1263 11822 0.09572 2.8e-005 245 3 M0442_1.02 (ZBTB3)_(Mus_musculus)_(DBD_1.00) NNTGCAGYG 1.1e-001 1.4e-004 -8.88 0.0 288 492 7437 12251 0.58537 5.7e-007 245 3 M0603_1.02 CGBP NNNBCGK 1.6e-005 2.0e-008 -17.71 0.0 266 494 2585 4409 0.53846 8.3e-011 246 3 M1919_1.02 YY1 CAARATGGCBGC 2.1e-031 2.6e-034 -77.33 0.0 283 489 6951 10896 0.57873 1.1e-036 244 3 M1926_1.02 ZEB1 CAGGTGWGB 2.6e-006 3.3e-009 -19.53 0.0 176 492 4463 11512 0.35772 1.3e-011 245 3 M2065_1.02 ESR2 RGGKCANBSTGACCT 1.3e0000 1.7e-003 -6.38 0.0 358 486 8235 10909 0.73663 7.0e-006 242 3 M2264_1.02 (ATOH1)_(Mus_musculus)_(DBD_1.00) RCCAKCTG 4.0e-005 5.0e-008 -16.81 0.0 301 493 7426 11626 0.61055 2.0e-010 246 3 M2277_1.02 FLI1 RCAGGAAGTGR 2.7e0000 3.4e-003 -5.69 0.0 376 490 9400 11998 0.76735 1.4e-005 244 3 M2299_1.02 (MYF5)_(Mus_musculus)_(DBD_0.90) NRNRRCAGCTGSN 6.7e-009 8.4e-012 -25.50 0.0 154 488 4041 11605 0.31557 3.5e-014 243 3 M2390_1.02 EHF SAGGAAGK 2.8e-003 3.5e-006 -12.56 0.0 327 493 7911 11505 0.66329 1.4e-008 246 3 M4438_1.02 ESRRA RGGTCANKSTGACCY 2.4e-001 3.0e-004 -8.12 0.0 412 486 9521 11024 0.84774 1.2e-006 242 3 M4444_1.02 RELA DGGGRMTTTCCMVN 9.3e0000 1.2e-002 -4.45 0.0 203 487 4345 9961 0.41684 4.8e-005 243 3 M4462_1.02 GABPA VVCCGGAAGTG 6.6e0000 8.2e-003 -4.80 0.0 398 490 9325 11278 0.81224 3.4e-005 244 3 M4469_1.02 REST TCCRTGGTGCTGAA 6.2e-002 7.8e-005 -9.46 0.0 179 487 3412 8670 0.36756 3.2e-007 243 3 M4479_1.02 TCF12 VSAGCAGSTGB 1.0e-002 1.3e-005 -11.27 0.0 120 490 3115 11698 0.24490 5.2e-008 244 3 M4522_1.02 ELK4 CCGGAAGYGS 1.4e0000 1.8e-003 -6.34 0.0 397 491 9627 11680 0.80855 7.2e-006 245 3 M4569_1.02 HSF1 GTCSYGGGTTCGADTCCC 3.1e-003 3.9e-006 -12.45 0.0 127 483 1464 4909 0.26294 1.6e-008 241 3 M4636_1.02 THAP1 YTGCCCDBANYMAAGATGGCG 4.1e-016 5.1e-019 -42.12 0.0 252 480 3474 5928 0.52500 2.1e-021 239 3 M4681_1.02 BACH2 TGCTGAGTCA 2.6e-003 3.2e-006 -12.64 0.0 297 491 5186 8168 0.60489 1.3e-008 245 3 M5377_1.02 ELF4 AACCCGGAAGTR 1.6e0000 2.0e-003 -6.19 0.0 393 489 7645 9309 0.80368 8.4e-006 244 3 M5420_1.02 ETV1 ACCGGAAGTD 8.5e0000 1.1e-002 -4.54 0.0 389 491 9288 11509 0.79226 4.4e-005 245 3 M5425_1.02 ETV6 CCGGAASCGGAAGYR 4.5e-005 5.6e-008 -16.69 0.0 352 486 6033 7990 0.72428 2.3e-010 242 3 M5497_1.02 GRHL1 AACCGGTYTAACCGGTT 1.6e0000 2.1e-003 -6.19 0.0 334 484 4374 6114 0.69008 8.5e-006 241 3 M5571_1.02 ID4 DVCAGGTGYN 5.0e-001 6.2e-004 -7.38 0.0 183 491 4549 11565 0.37271 2.5e-006 245 3 M5627_1.02 MESP1 NVCAGGTGYD 7.8e0000 9.8e-003 -4.63 0.0 157 491 4053 12039 0.31976 4.0e-005 245 3 M5883_1.02 TBX20 TCACACSTTCACACCT 3.2e0000 4.0e-003 -5.52 0.0 187 485 2361 5723 0.38557 1.7e-005 242 3 M5896_1.02 TBX4 AGGTGTGA 1.7e0000 2.1e-003 -6.18 0.0 185 493 4666 11827 0.37525 8.4e-006 246 3 M5955_1.02 YY2 WAATGGCGGWY 5.4e-014 6.8e-017 -37.22 0.0 260 490 6365 11115 0.53061 2.8e-019 244 3 M5974_1.02 ZNF524 GGGTTCRAGGGT 6.2e-004 7.8e-007 -14.06 0.0 139 489 2593 8275 0.28425 3.2e-009 244 3 M5980_1.02 ZNF784 AGGTAGGTAC 2.3e-001 2.8e-004 -8.17 0.0 139 491 2404 7819 0.28310 1.2e-006 245 3 M6115_1.02 TP73 CATGYCWGRRCHTGY 3.1e-003 3.9e-006 -12.47 0.0 324 486 7588 10974 0.66667 1.6e-008 242 3 M6131_1.02 (TFCP2L1)_(Mus_musculus)_(DBD_0.95) CYRGYTCHRDCYRGYTYNRDC 5.7e-002 7.2e-005 -9.54 0.0 328 480 7910 11217 0.68333 3.0e-007 239 3 M6154_1.02 ATF5 TAAGGRAGARGK 1.2e-002 1.5e-005 -11.10 0.0 217 489 5526 11808 0.44376 6.2e-008 244 3 M6161_1.02 BHLHE41 WSVRKSYCACGTGMHGRRRV 2.1e-002 2.6e-005 -10.55 0.0 143 481 3316 10338 0.29730 1.1e-007 240 3 M6208_1.02 ELK3 VMCHGGAARTSC 7.8e-002 9.7e-005 -9.24 0.0 385 489 9008 11173 0.78732 4.0e-007 244 3 M6221_1.02 ETS2 VMVGGAAGTKS 6.0e-001 7.6e-004 -7.18 0.0 392 490 10018 12274 0.80000 3.1e-006 244 3 M6270_1.02 NHLH1 RRGGMCGCAGCTGMKMCCCV 3.6e0000 4.5e-003 -5.41 0.0 325 481 5650 8106 0.67568 1.9e-005 240 3 M6271_1.02 HES1 KGKCKCGTGBCKB 8.7e0000 1.1e-002 -4.51 0.0 278 488 6990 11899 0.56967 4.5e-005 243 3 M6276_1.02 HINFP DMSNHMGCGGACGTTV 1.4e-003 1.8e-006 -13.25 0.0 323 485 5247 7532 0.66598 7.2e-009 242 3 M6316_1.02 TCF4 VCAGGTGCD 5.7e-002 7.2e-005 -9.54 0.0 112 492 2715 10951 0.22764 2.9e-007 245 3 M6330_1.02 MAFA STGCTGACBMYGCARYHTYCV 5.1e-005 6.4e-008 -16.56 0.0 364 480 9274 11851 0.75833 2.7e-010 239 3 M6346_1.02 MLXIPL VCACGVSGKKGBCMCRTGC 2.2e-001 2.7e-004 -8.21 0.0 278 482 4634 7680 0.57676 1.1e-006 240 3 M6353_1.02 MYF6 GCAGSTG 1.3e-002 1.6e-005 -11.05 0.0 114 494 2976 11836 0.23077 6.5e-008 246 3 M6354_1.02 MYOD1 RACAGSTGS 8.6e0000 1.1e-002 -4.53 0.0 120 492 3129 12063 0.24390 4.4e-005 245 3 M6355_1.02 MYOG YRACAGCTGCWGC 1.9e0000 2.4e-003 -6.01 0.0 158 488 3751 10937 0.32377 1.0e-005 243 3 M6360_1.02 NFE2L2 VRTGACTCAGCA 7.8e0000 9.8e-003 -4.62 0.0 417 489 10163 11742 0.85276 4.1e-005 244 3 M6445_1.02 RARB BBBBTGACCTS 4.2e-004 5.3e-007 -14.46 0.0 370 490 9243 11879 0.75510 2.2e-009 244 3 M6463_1.02 SMAD1 RSCCTGTCTGCC 7.0e-001 8.8e-004 -7.03 0.0 233 489 5969 12011 0.47648 3.6e-006 244 3 M6464_1.02 SMAD2 GTGTCHGKCTV 7.3e-003 9.2e-006 -11.60 0.0 202 490 5270 12075 0.41224 3.8e-008 244 3 M6465_1.02 SMAD3 STGTCTGBCY 2.1e-002 2.6e-005 -10.54 0.0 207 491 5431 12209 0.42159 1.1e-007 245 3 M6466_1.02 SMAD4 TGTCTGBCY 2.4e-003 3.0e-006 -12.73 0.0 202 492 5234 12012 0.41057 1.2e-008 245 3 M6468_1.02 SNAI1 SCAGGTGK 1.7e0000 2.1e-003 -6.14 0.0 165 493 4190 11857 0.33469 8.7e-006 246 3 M6498_1.02 NR5A1 TGRCCTTGR 3.0e0000 3.7e-003 -5.60 0.0 298 492 7450 11932 0.60569 1.5e-005 245 3 M6505_1.02 TBX5 AGGTGTGA 1.7e0000 2.1e-003 -6.14 0.0 117 493 3063 12052 0.23732 8.7e-006 246 3 M6513_1.02 TFAP4 RYCAGCTGYGG 1.1e0000 1.4e-003 -6.54 0.0 120 490 2787 10579 0.24490 5.9e-006 244 3 M6527_1.02 TWIST1 MCCCAGGTGK 4.2e0000 5.2e-003 -5.25 0.0 189 491 4092 10109 0.38493 2.1e-005 245 3 M6542_1.02 ZBTB6 VGRTGATRGAGCC 2.7e-002 3.4e-005 -10.30 0.0 252 488 5746 10614 0.51639 1.4e-007 243 3 M6545_1.02 HIVEP2 GGYDGGGWAACYSS 2.9e0000 3.6e-003 -5.63 0.0 287 487 7374 12129 0.58932 1.5e-005 243 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # consensus: A consensus sequence computed from the motif. # E-value: The expected number motifs that would have least one. # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).