Figure A: For our downstream analyses, we typically merge motifs discovered by TF-MoDISco between the count and profile heads of the multi-task neural network. We merge together motifs of sufficiently high similarity. Below, we show the motifs between the profile and count heads which have been merged, along with their cosine similarity.
Multi-task fold_1
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9913 |
|
|
| C0_1:P0_1 | 0.9907 |
|
|
| C0_3:P0_4 | 0.9677 |
|
|
| C0_2:P0_5 | 0.9090 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_4 |
|
P0_2 |
|
| C0_5 |
|
P0_3 |
|
| P0_6 |
|
||
| P0_7 |
|
||
| P0_8 |
|
||
| P0_9 |
|
||
| P0_10 |
|
Multi-task fold_10
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9973 |
|
|
| C0_1:P0_1 | 0.9934 |
|
|
| C0_3:P0_3 | 0.9662 |
|
|
| C0_2:P0_6 | 0.9434 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_4 |
|
P0_2 |
|
| C0_5 |
|
P0_4 |
|
| C0_6 |
|
P0_5 |
|
| C0_7 |
|
P0_7 |
|
| P0_8 |
|
||
| P0_9 |
|
||
| P0_10 |
|
||
| P0_11 |
|
Multi-task fold_2
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9908 |
|
|
| C0_5:P0_6 | 0.9856 |
|
|
| C0_1:P0_1 | 0.9684 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_2 |
|
P0_2 |
|
| C0_3 |
|
P0_3 |
|
| C0_4 |
|
P0_4 |
|
| P0_5 |
|
||
| P0_7 |
|
||
| P0_8 |
|
||
| P0_9 |
|
||
| P1_0 |
|
Multi-task fold_3
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9938 |
|
|
| C0_2:P0_2 | 0.9917 |
|
|
| C0_3:P0_4 | 0.9850 |
|
|
| C0_4:P0_3 | 0.9520 |
|
|
| C0_1:P0_1 | 0.9309 |
|
|
| C0_5:P0_8 | 0.9250 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_6 |
|
P0_5 |
|
| C0_7 |
|
P0_6 |
|
| C0_8 |
|
P0_7 |
|
| P0_9 |
|
||
| P0_10 |
|
Multi-task fold_4
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9972 |
|
|
| C0_2:P0_3 | 0.9295 |
|
|
| C0_1:P0_1 | 0.9210 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_3 |
|
P0_2 |
|
| C0_4 |
|
P0_4 |
|
| C0_5 |
|
P0_5 |
|
| P1_0 |
|
||
| P1_1 |
|
Multi-task fold_5
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9973 |
|
|
| C0_1:P0_1 | 0.9835 |
|
|
| C0_3:P0_3 | 0.9398 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_2 |
|
P0_2 |
|
| C0_4 |
|
P0_4 |
|
| C0_5 |
|
P0_5 |
|
| C0_6 |
|
P0_6 |
|
| P0_7 |
|
Multi-task fold_6
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_5:P0_4 | 0.9898 |
|
|
| C0_4:P0_5 | 0.9800 |
|
|
| C0_1:P0_1 | 0.9790 |
|
|
| C0_3:P0_11 | 0.9534 |
|
|
| C0_0:P0_0 | 0.9488 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_2 |
|
P0_2 |
|
| P0_3 |
|
||
| P0_6 |
|
||
| P0_7 |
|
||
| P0_8 |
|
||
| P0_9 |
|
||
| P0_10 |
|
||
| P0_12 |
|
||
| P0_13 |
|
Multi-task fold_7
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9728 |
|
|
| C0_2:P0_5 | 0.9630 |
|
|
| C0_3:P0_4 | 0.9516 |
|
|
| C0_1:P0_1 | 0.9029 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| P0_2 |
|
||
| P0_3 |
|
||
| P0_6 |
|
||
| P0_7 |
|
||
| P0_8 |
|
||
| P0_9 |
|
||
| P0_10 |
|
||
| P1_0 |
|
Multi-task fold_8
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9912 |
|
|
| C0_3:P0_3 | 0.9832 |
|
|
| C0_4:P0_4 | 0.9739 |
|
|
| C0_6:P0_10 | 0.9698 |
|
|
| C0_1:P0_1 | 0.9564 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_2 |
|
P0_2 |
|
| C0_5 |
|
P0_5 |
|
| P0_6 |
|
||
| P0_7 |
|
||
| P0_8 |
|
||
| P0_9 |
|
||
| P0_11 |
|
||
| P0_12 |
|
Multi-task fold_9
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9971 |
|
|
| C0_2:P0_2 | 0.9872 |
|
|
| C0_3:P0_3 | 0.9558 |
|
|
| C0_1:P0_1 | 0.9306 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_4 |
|
P0_4 |
|
| P0_5 |
|
||
| P1_0 |
|
Single-task task_0 fold_1
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_1:P0_1 | 0.9973 |
|
|
| C0_2:P0_2 | 0.9851 |
|
|
| C0_0:P0_0 | 0.9843 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_3 |
|
P0_3 |
|
| P0_4 |
|
Single-task task_0 fold_10
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9883 |
|
|
| C0_5:P0_9 | 0.9809 |
|
|
| C0_3:P0_2 | 0.9696 |
|
|
| C0_1:P0_1 | 0.9421 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_2 |
|
P0_3 |
|
| C0_4 |
|
P0_4 |
|
| C0_6 |
|
P0_5 |
|
| P0_6 |
|
||
| P0_7 |
|
||
| P0_8 |
|
||
| P0_10 |
|
||
| P0_11 |
|
Single-task task_0 fold_2
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_3:P0_3 | 0.9928 |
|
|
| C0_2:P0_2 | 0.9794 |
|
|
| C0_0:P0_0 | 0.9757 |
|
|
| C0_4:P0_4 | 0.9740 |
|
|
| C0_1:P0_1 | 0.9702 |
|
|
| C0_7:P0_6 | 0.9191 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_5 |
|
P0_5 |
|
| C0_6 |
|
P0_7 |
|
| P0_8 |
|
Single-task task_0 fold_3
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_1:P0_1 | 0.9913 |
|
|
| C0_0:P0_0 | 0.9885 |
|
|
| C0_2:P0_2 | 0.9635 |
|
|
| C0_3:P0_3 | 0.9631 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| P0_4 |
|
||
| P0_5 |
|
||
| P1_0 |
|
||
| P1_1 |
|
Single-task task_0 fold_4
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9947 |
|
|
| C0_1:P0_1 | 0.9942 |
|
|
| C0_2:P0_2 | 0.9604 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_3 |
|
P0_3 |
|
| C0_4 |
|
P0_4 |
|
| P0_5 |
|
||
| P0_6 |
|
||
| P0_7 |
|
||
| P0_8 |
|
||
| P0_9 |
|
||
| P0_10 |
|
||
| P0_11 |
|
||
| P0_12 |
|
||
| P0_13 |
|
||
| P0_14 |
|
||
| P0_15 |
|
Single-task task_0 fold_5
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_1:P0_1 | 0.9943 |
|
|
| C0_2:P0_2 | 0.9645 |
|
|
| C0_0:P0_0 | 0.9270 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| P0_3 |
|
||
| P0_4 |
|
||
| P0_5 |
|
||
| P0_6 |
|
Single-task task_0 fold_6
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_1:P0_1 | 0.9980 |
|
|
| C0_0:P0_0 | 0.9968 |
|
|
| C0_2:P0_6 | 0.9400 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_3 |
|
P0_2 |
|
| C0_4 |
|
P0_3 |
|
| C0_5 |
|
P0_4 |
|
| P0_5 |
|
||
| P0_7 |
|
||
| P0_8 |
|
Single-task task_0 fold_7
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9962 |
|
|
| C0_3:P0_4 | 0.9923 |
|
|
| C0_1:P0_2 | 0.9914 |
|
|
| C0_4:P0_3 | 0.9888 |
|
|
| C0_2:P0_1 | 0.9108 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_5 |
|
P0_5 |
|
| C0_6 |
|
Single-task task_0 fold_8
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9969 |
|
|
| C0_1:P0_1 | 0.9947 |
|
|
| C0_4:P0_4 | 0.9800 |
|
|
| C0_3:P0_3 | 0.9691 |
|
|
| C0_2:P0_5 | 0.9347 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_5 |
|
P0_2 |
|
| P0_6 |
|
||
| P0_7 |
|
||
| P0_8 |
|
Single-task task_0 fold_9
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9955 |
|
|
| C0_1:P0_2 | 0.9841 |
|
|
| C0_2:P0_1 | 0.9772 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| P0_3 |
|
||
| P1_0 |
|
Single-task task_1 fold_1
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9964 |
|
|
| C0_1:P0_2 | 0.9947 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_2 |
|
P0_1 |
|
| C0_3 |
|
P0_3 |
|
| P0_4 |
|
||
| P0_5 |
|
||
| P0_6 |
|
Single-task task_1 fold_10
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9951 |
|
|
| C0_1:P0_1 | 0.9922 |
|
|
| C0_2:P0_2 | 0.9377 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_3 |
|
P0_3 |
|
| P0_4 |
|
||
| P0_5 |
|
||
| P0_6 |
|
Single-task task_1 fold_2
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9903 |
|
|
| C0_3:P0_1 | 0.9781 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_1 |
|
P0_2 |
|
| C0_2 |
|
P0_3 |
|
| P0_4 |
|
||
| P0_5 |
|
||
| P0_6 |
|
Single-task task_1 fold_3
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9927 |
|
|
| C0_2:P0_1 | 0.9796 |
|
|
| C0_1:P0_5 | 0.9714 |
|
|
| C0_5:P0_3 | 0.9423 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_3 |
|
P0_2 |
|
| C0_4 |
|
P0_4 |
|
| P0_6 |
|
||
| P0_7 |
|
||
| P0_8 |
|
||
| P0_9 |
|
Single-task task_1 fold_4
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9918 |
|
|
| C0_1:P0_2 | 0.9831 |
|
|
| C0_3:P0_3 | 0.9708 |
|
|
| C0_2:P0_1 | 0.9044 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| P0_4 |
|
||
| P0_5 |
|
Single-task task_1 fold_5
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_2:P0_1 | 0.9907 |
|
|
| C0_3:P0_2 | 0.9904 |
|
|
| C0_1:P0_3 | 0.9792 |
|
|
| C0_0:P0_0 | 0.9766 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| P0_4 |
|
||
| P0_5 |
|
||
| P0_6 |
|
||
| P0_7 |
|
||
| P0_8 |
|
||
| P0_9 |
|
||
| P0_10 |
|
Single-task task_1 fold_6
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_1 | 0.9955 |
|
|
| C0_2:P0_2 | 0.9942 |
|
|
| C0_1:P0_4 | 0.9403 |
|
|
| C0_4:P0_0 | 0.9243 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_3 |
|
P0_3 |
|
| C0_5 |
|
P0_5 |
|
| P0_6 |
|
||
| P0_7 |
|
||
| P0_8 |
|
||
| P0_9 |
|
||
| P0_10 |
|
||
| P1_0 |
|
Single-task task_1 fold_7
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9941 |
|
|
| C0_3:P0_3 | 0.9895 |
|
|
| C0_1:P0_1 | 0.9879 |
|
|
| C0_2:P0_5 | 0.9443 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_4 |
|
P0_2 |
|
| P0_4 |
|
||
| P0_6 |
|
||
| P0_7 |
|
Single-task task_1 fold_8
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9838 |
|
|
| C0_4:P0_2 | 0.9740 |
|
|
| C0_3:P0_1 | 0.9551 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_1 |
|
P0_3 |
|
| C0_2 |
|
P0_4 |
|
| C0_5 |
|
P0_5 |
|
| C0_6 |
|
P0_6 |
|
| P0_7 |
|
||
| P0_8 |
|
||
| P0_9 |
|
Single-task task_1 fold_9
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9992 |
|
|
| C0_2:P0_1 | 0.9899 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_1 |
|
P0_2 |
|
| C0_3 |
|
P0_3 |
|
| C0_4 |
|
P0_4 |
|
| P0_5 |
|
Multi-task fine-tune task_0
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9977 |
|
|
| C0_2:P0_2 | 0.9945 |
|
|
| C0_1:P0_1 | 0.9825 |
|
|
| C0_3:P0_3 | 0.9671 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_4 |
|
P0_4 |
|
| C0_5 |
|
P0_5 |
|
| C0_6 |
|
P0_6 |
|
| P0_7 |
|
||
| P0_8 |
|
||
| P0_9 |
|
Multi-task fine-tune task_1
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9866 |
|
|
| C0_3:P0_3 | 0.9764 |
|
|
| C0_1:P0_1 | 0.9729 |
|
|
| C0_2:P0_7 | 0.9437 |
|
|
| C0_6:P0_2 | 0.9433 |
|
|
| C0_4:P0_5 | 0.9096 |
|
|
| C0_7:P0_11 | 0.9027 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_5 |
|
P0_4 |
|
| P0_6 |
|
||
| P0_8 |
|
||
| P0_9 |
|
||
| P0_10 |
|
||
| P0_12 |
|
Multi-task fine-tune task_agg
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9928 |
|
|
| C0_1:P0_1 | 0.9863 |
|
|
| C0_3:P0_5 | 0.9570 |
|
|
| C0_2:P0_2 | 0.9499 |
|
|
| C0_5:P0_8 | 0.9076 |
|
|
| C0_4:P0_3 | 0.9011 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| P0_4 |
|
||
| P0_6 |
|
||
| P0_7 |
|
||
| P0_9 |
|
||
| P0_10 |
|
||
| P0_11 |
|
Single-task fine-tune task_0
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9872 |
|
|
| C0_4:P0_9 | 0.9676 |
|
|
| C0_3:P0_2 | 0.9515 |
|
|
| C0_1:P0_1 | 0.9165 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_2 |
|
P0_3 |
|
| P0_4 |
|
||
| P0_5 |
|
||
| P0_6 |
|
||
| P0_7 |
|
||
| P0_8 |
|
||
| P0_10 |
|
||
| P0_11 |
|
Single-task fine-tune task_1
Matched motifs
| Merged ID | Similarity | Aggregate motif | Constituent motifs |
|---|---|---|---|
| C0_0:P0_0 | 0.9981 |
|
|
| C0_2:P0_2 | 0.9943 |
|
|
Unmatched motifs
| Count ID | Count motif | Profile ID | Profile motif |
|---|---|---|---|
| C0_1 |
|
P0_1 |
|
| P0_3 |
|
||
| P0_4 |
|
||
| P0_5 |
|