DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1794 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1999 |
|
| 5 | 1694 |
|
| 6 | 1074 |
|
| 7 | 485 |
|
| 8 | 348 |
|
| 9 | 150 |
|
| 10 | 50 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 17288 |
|
15322 |
|
| 2 | 1111 |
|
249 |
|
| 3 | 75 |
|
||
| 4 | 28 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 15846 |
|
16950 |
|
| 2 | 2021 |
|
1069 |
|
| 3 | 228 |
|
||
| 4 | 85 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -97513.061322 |
|
| 2 | -11200.609519 |
|
| 3 | -9509.563045 |
|
| 4 | -8004.740707 |
|
| 5 | -5371.739323 |
|
| 6 | -4998.899257 |
|
| 7 | -4626.620209 |
|
| 8 | -4615.854215 |
|
| 9 | -3000.614276 |
|
| 10 | -2944.778297 |
|
| 11 | -2606.066978 |
|
| 12 | -2386.081055 |
|
| 13 | -1455.323166 |
|
| 14 | -1127.391528 |
|
| 15 | -1100.140792 |
|
| 16 | -900.442516 |
|
| 17 | -867.526789 |
|
| 18 | -683.668752 |
|
| 19 | -428.255974 |
|
| 20 | -1130.086773 |
|
| 21 | -780.597556 |
|
| 22 | -313.169964 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -27129.133696 |
|
-35264.89242 |
|
| 2 | -359.308485 |
|
-306.345416 |
|
| 3 | -226.9422 |
|
-280.90939 |
|
| 4 | -179.931716 |
|
-149.347293 |
|
| 5 | -173.726381 |
|
-144.390348 |
|
| 6 | -128.512366 |
|
-124.844891 |
|
| 7 | -125.983338 |
|
-119.690265 |
|
| 8 | -115.465726 |
|
-110.506554 |
|
| 9 | -78.456156 |
|
-78.300998 |
|
| 10 | -76.100396 |
|
||
| 11 | -65.266633 |
|
||
| 12 | -55.998319 |
|
||
| 13 | -8.789294 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -20965.01913 |
|
-28404.601742 |
|
| 2 | -1393.686511 |
|
-2057.913081 |
|
| 3 | -533.37818 |
|
-547.23356 |
|
| 4 | -463.228254 |
|
-347.921717 |
|
| 5 | -278.177036 |
|
-347.921717 |
|
| 6 | -260.030482 |
|
-223.459932 |
|
| 7 | -229.602084 |
|
-205.821737 |
|
| 8 | -180.574956 |
|
-183.383379 |
|
| 9 | -170.339216 |
|
-137.169998 |
|
| 10 | -160.200067 |
|
-125.059022 |
|
| 11 | -125.549109 |
|
-69.607438 |
|
| 12 | -120.71536 |
|
-47.546723 |
|
| 13 | -115.913393 |
|
||
| 14 | -83.239485 |
|
||
| 15 | -25.328904 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 4.3e-69 |
|
| 3 | 6.5e-43 |
|
| 4 | 2.9e-41 |
|
| 5 | 9.6e-40 |
|
| 6 | 3e-32 |
|
| 7 | 5.2e-21 |
|
| 8 | 1.5e-14 |
|
| 9 | 4.8e-07 |
|
| 10 | 1.9e-05 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 0.025 |
|
3.6 |
|
| 3 | 40000.0 |
|
240.0 |
|
| 4 | 81000.0 |
|
14000.0 |
|
| 5 | 3200000.0 |
|
1600000.0 |
|
| 6 | 4500000.0 |
|
2200000.0 |
|
| 7 | 5800000.0 |
|
4900000.0 |
|
| 8 | 5800000.0 |
|
5200000.0 |
|
| 9 | 5800000.0 |
|
5200000.0 |
|
| 10 | 6000000.0 |
|
5200000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 0.00032 |
|
9.2e-05 |
|
| 3 | 810.0 |
|
0.0027 |
|
| 4 | 74000.0 |
|
0.6 |
|
| 5 | 520000.0 |
|
5900.0 |
|
| 6 | 600000.0 |
|
15000.0 |
|
| 7 | 1700000.0 |
|
49000.0 |
|
| 8 | 2400000.0 |
|
2800000.0 |
|
| 9 | 2800000.0 |
|
5000000.0 |
|
| 10 | 2800000.0 |
|
6200000.0 |
|