DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1667 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1826 |
|
| 6 | 1144 |
|
| 7 | 561 |
|
| 8 | 273 |
|
| 9 | 139 |
|
| 10 | 58 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 16137 |
|
17028 |
|
| 2 | 847 |
|
568 |
|
| 3 | 334 |
|
||
| 4 | 97 |
|
||
| 5 | 6 |
|
||
| 6 | 1 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 15706 |
|
16404 |
|
| 2 | 1935 |
|
493 |
|
| 3 | 576 |
|
||
| 4 | 65 |
|
||
| 5 | 11 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -74318.478428 |
|
| 2 | -9385.310106 |
|
| 3 | -7447.65901 |
|
| 4 | -4229.335831 |
|
| 5 | -3707.046765 |
|
| 6 | -2666.475276 |
|
| 7 | -2344.488054 |
|
| 8 | -1760.870176 |
|
| 9 | -956.682553 |
|
| 10 | -475.592939 |
|
| 11 | -419.093352 |
|
| 12 | -372.249181 |
|
| 13 | -369.205837 |
|
| 14 | -357.735367 |
|
| 15 | -307.409063 |
|
| 16 | -302.755733 |
|
| 17 | -245.315116 |
|
| 18 | -108.451725 |
|
| 19 | -217.757313 |
|
| 20 | -155.0108 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -23092.428474 |
|
-31362.4897 |
|
| 2 | -1837.675776 |
|
-3577.529813 |
|
| 3 | -510.367692 |
|
-295.220791 |
|
| 4 | -248.390311 |
|
-208.151322 |
|
| 5 | -238.311792 |
|
-204.333771 |
|
| 6 | -159.322842 |
|
-186.55716 |
|
| 7 | -120.609784 |
|
-159.071416 |
|
| 8 | -120.274935 |
|
-139.219427 |
|
| 9 | -113.222033 |
|
-96.298432 |
|
| 10 | -105.62363 |
|
-82.467544 |
|
| 11 | -96.676414 |
|
-45.358227 |
|
| 12 | -90.880851 |
|
||
| 13 | -59.717861 |
|
||
| 14 | -44.363708 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -24276.894096 |
|
-27328.044075 |
|
| 2 | -2856.109783 |
|
-5285.06003 |
|
| 3 | -703.7432 |
|
-1524.200348 |
|
| 4 | -655.254696 |
|
-1037.817288 |
|
| 5 | -144.489959 |
|
-571.253179 |
|
| 6 | -115.110446 |
|
-258.621515 |
|
| 7 | -102.515382 |
|
-212.809709 |
|
| 8 | -87.371972 |
|
-212.41202 |
|
| 9 | -77.67442 |
|
-159.254635 |
|
| 10 | -65.185119 |
|
-156.617233 |
|
| 11 | -49.741703 |
|
-75.756735 |
|
| 12 | -3.558332 |
|
-44.108199 |
|
| 13 | -34.764381 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 1.8e-30 |
|
| 3 | 2.4e-16 |
|
| 4 | 4.9e-10 |
|
| 5 | 5.2e-09 |
|
| 6 | 0.44 |
|
| 7 | 0.93 |
|
| 8 | 16.0 |
|
| 9 | 0.5 |
|
| 10 | 17.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 900.0 |
|
7.8e-07 |
|
| 3 | 5400.0 |
|
4500.0 |
|
| 4 | 8300.0 |
|
91000.0 |
|
| 5 | 55000.0 |
|
3400000.0 |
|
| 6 | 210000.0 |
|
3900000.0 |
|
| 7 | 1100000.0 |
|
4500000.0 |
|
| 8 | 1600000.0 |
|
6500000.0 |
|
| 9 | 3000000.0 |
|
6900000.0 |
|
| 10 | 5400000.0 |
|
6900000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 0.094 |
|
1.5e-10 |
|
| 3 | 1000.0 |
|
45.0 |
|
| 4 | 30000.0 |
|
1100000.0 |
|
| 5 | 200000.0 |
|
1100000.0 |
|
| 6 | 1400000.0 |
|
1900000.0 |
|
| 7 | 2200000.0 |
|
3500000.0 |
|
| 8 | 4000000.0 |
|
3000000.0 |
|
| 9 | 300000.0 |
|
3600000.0 |
|
| 10 | 3900000.0 |
|
4200000.0 |
|