DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1788 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1996 |
|
| 5 | 1643 |
|
| 6 | 851 |
|
| 7 | 262 |
|
| 8 | 38 |
|
| 9 | 7 |
|
| 10 | 7 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 17091 |
|
15094 |
|
| 2 | 1489 |
|
343 |
|
| 3 | 92 |
|
||
| 4 | 32 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 16281 |
|
17787 |
|
| 2 | 1089 |
|
801 |
|
| 3 | 518 |
|
127 |
|
| 4 | 84 |
|
||
| 5 | 24 |
|
||
| 6 | 1 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -51176.736656 |
|
| 2 | -5361.18781 |
|
| 3 | -4808.173915 |
|
| 4 | -3547.634458 |
|
| 5 | -2361.264039 |
|
| 6 | -2328.141618 |
|
| 7 | -1897.33823 |
|
| 8 | -1538.527221 |
|
| 9 | -1360.970984 |
|
| 10 | -1280.610714 |
|
| 11 | -1227.922649 |
|
| 12 | -1198.335712 |
|
| 13 | -852.256981 |
|
| 14 | -682.26357 |
|
| 15 | -631.984363 |
|
| 16 | -453.405926 |
|
| 17 | -428.207383 |
|
| 18 | -426.51931 |
|
| 19 | -387.633967 |
|
| 20 | -296.718383 |
|
| 21 | -221.901096 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -27881.151844 |
|
-39871.55919 |
|
| 2 | -472.443361 |
|
-263.187068 |
|
| 3 | -219.02269 |
|
-197.98379 |
|
| 4 | -205.682394 |
|
-189.158446 |
|
| 5 | -205.682394 |
|
-162.818586 |
|
| 6 | -190.981626 |
|
-143.789671 |
|
| 7 | -154.475376 |
|
-131.914809 |
|
| 8 | -154.475376 |
|
-105.327244 |
|
| 9 | -154.475376 |
|
||
| 10 | -129.812574 |
|
||
| 11 | -128.388373 |
|
||
| 12 | -124.093875 |
|
||
| 13 | -111.373532 |
|
||
| 14 | -87.396666 |
|
||
| 15 | -73.943747 |
|
||
| 16 | -69.54979 |
|
||
| 17 | -64.945098 |
|
||
| 18 | -59.908156 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -25539.944217 |
|
-32128.929499 |
|
| 2 | -703.225335 |
|
-779.16079 |
|
| 3 | -631.263788 |
|
-589.323181 |
|
| 4 | -376.267093 |
|
-242.316007 |
|
| 5 | -289.987211 |
|
-232.75567 |
|
| 6 | -262.295581 |
|
-147.18227 |
|
| 7 | -237.488742 |
|
-144.840258 |
|
| 8 | -166.839606 |
|
-124.691771 |
|
| 9 | -159.530122 |
|
-123.778234 |
|
| 10 | -149.382773 |
|
-119.519081 |
|
| 11 | -84.307352 |
|
-91.750944 |
|
| 12 | -61.552534 |
|
-75.691119 |
|
| 13 | -60.929621 |
|
-57.10528 |
|
| 14 | -45.149809 |
|
-52.351856 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 1.9e-74 |
|
| 3 | 1.1e-27 |
|
| 4 | 8e-15 |
|
| 5 | 0.063 |
|
| 6 | 0.23 |
|
| 7 | 12.0 |
|
| 8 | 1100.0 |
|
| 9 | 3100.0 |
|
| 10 | 6900.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 3e-13 |
|
1500000.0 |
|
| 3 | 0.0012 |
|
14000000.0 |
|
| 4 | 1800.0 |
|
14000000.0 |
|
| 5 | 34.0 |
|
14000000.0 |
|
| 6 | 2100.0 |
|
18000000.0 |
|
| 7 | 310000.0 |
|
21000000.0 |
|
| 8 | 1200000.0 |
|
21000000.0 |
|
| 9 | 2600000.0 |
|
15000000.0 |
|
| 10 | 3800000.0 |
|
20000000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 660.0 |
|
1.5 |
|
| 3 | 570000.0 |
|
800.0 |
|
| 4 | 50000000.0 |
|
1700000.0 |
|
| 5 | 110000000.0 |
|
3100000.0 |
|
| 6 | 110000000.0 |
|
6100000.0 |
|
| 7 | 110000000.0 |
|
6400000.0 |
|
| 8 | 120000000.0 |
|
6600000.0 |
|
| 9 | 120000000.0 |
|
6600000.0 |
|
| 10 | 190000000.0 |
|
9100000.0 |
|