DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1784 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1999 |
|
| 5 | 1964 |
|
| 6 | 1075 |
|
| 7 | 646 |
|
| 8 | 64 |
|
| 9 | 13 |
|
| 10 | 6 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 16113 |
|
17201 |
|
| 2 | 2102 |
|
670 |
|
| 3 | 175 |
|
||
| 4 | 61 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 16667 |
|
17564 |
|
| 2 | 1357 |
|
450 |
|
| 3 | 241 |
|
||
| 4 | 32 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -64790.495697 |
|
| 2 | -7433.778242 |
|
| 3 | -5306.227773 |
|
| 4 | -5130.152357 |
|
| 5 | -4296.537801 |
|
| 6 | -3423.672602 |
|
| 7 | -3254.890831 |
|
| 8 | -2932.209022 |
|
| 9 | -2344.685426 |
|
| 10 | -1708.631647 |
|
| 11 | -1098.18344 |
|
| 12 | -550.211216 |
|
| 13 | -459.886359 |
|
| 14 | -343.934756 |
|
| 15 | -340.529205 |
|
| 16 | -331.427164 |
|
| 17 | -239.247812 |
|
| 18 | -230.231119 |
|
| 19 | -199.225366 |
|
| 20 | -181.786939 |
|
| 21 | -36.316648 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -27390.8259 |
|
-32440.532975 |
|
| 2 | -1146.294823 |
|
-1993.259712 |
|
| 3 | -576.105708 |
|
-328.800549 |
|
| 4 | -351.619137 |
|
-105.604732 |
|
| 5 | -229.656897 |
|
-103.637905 |
|
| 6 | -184.941172 |
|
-102.702309 |
|
| 7 | -169.606666 |
|
-100.933615 |
|
| 8 | -147.846689 |
|
-87.144212 |
|
| 9 | -120.162547 |
|
-55.726493 |
|
| 10 | -102.818211 |
|
||
| 11 | -74.894911 |
|
||
| 12 | -65.21168 |
|
||
| 13 | -51.737912 |
|
||
| 14 | -28.824946 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -28363.814595 |
|
-32640.52903 |
|
| 2 | -5106.951901 |
|
-1282.752977 |
|
| 3 | -200.100759 |
|
-399.643012 |
|
| 4 | -168.66686 |
|
-139.175603 |
|
| 5 | -149.381298 |
|
-134.282514 |
|
| 6 | -144.423427 |
|
-109.717576 |
|
| 7 | -123.988009 |
|
-106.799294 |
|
| 8 | -115.485639 |
|
-96.262698 |
|
| 9 | -115.485639 |
|
-75.311314 |
|
| 10 | -111.276366 |
|
-74.590833 |
|
| 11 | -96.4979 |
|
-44.142673 |
|
| 12 | -86.014586 |
|
||
| 13 | -82.825953 |
|
||
| 14 | -25.142531 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 1.8e-38 |
|
| 3 | 6.6e-09 |
|
| 4 | 3.5e-07 |
|
| 5 | 0.016 |
|
| 6 | 0.023 |
|
| 7 | 0.2 |
|
| 8 | 1.3 |
|
| 9 | 140.0 |
|
| 10 | 1400.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 0.34 |
|
1.6 |
|
| 3 | 330.0 |
|
2700.0 |
|
| 4 | 34000.0 |
|
98000.0 |
|
| 5 | 84000.0 |
|
320000.0 |
|
| 6 | 220000.0 |
|
2200000.0 |
|
| 7 | 500000.0 |
|
2500000.0 |
|
| 8 | 670000.0 |
|
4400000.0 |
|
| 9 | 1400000.0 |
|
4400000.0 |
|
| 10 | 2700000.0 |
|
4700000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 9.5e-11 |
|
18000.0 |
|
| 3 | 0.02 |
|
120000.0 |
|
| 4 | 5800.0 |
|
2700000.0 |
|
| 5 | 100000.0 |
|
2700000.0 |
|
| 6 | 1800000.0 |
|
2300000.0 |
|
| 7 | 3100000.0 |
|
2700000.0 |
|
| 8 | 1900000.0 |
|
4200000.0 |
|
| 9 | 2200000.0 |
|
4400000.0 |
|
| 10 | 4200000.0 |
|
5000000.0 |
|