DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1502 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1854 |
|
| 6 | 1284 |
|
| 7 | 747 |
|
| 8 | 449 |
|
| 9 | 312 |
|
| 10 | 221 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 11162 |
|
6796 |
|
| 2 | 5398 |
|
537 |
|
| 3 | 19 |
|
232 |
|
| 4 | 104 |
|
||
| 5 | 198 |
|
||
| 6 | 22 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 10326 |
|
7737 |
|
| 2 | 3313 |
|
1118 |
|
| 3 | 1188 |
|
374 |
|
| 4 | 141 |
|
||
| 5 | 58 |
|
||
| 6 | 12 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -8921.260626 |
|
| 2 | -3144.004253 |
|
| 3 | -2561.159548 |
|
| 4 | -2240.440491 |
|
| 5 | -2120.519292 |
|
| 6 | -1857.186995 |
|
| 7 | -1584.429546 |
|
| 8 | -1221.93024 |
|
| 9 | -1076.7959 |
|
| 10 | -659.301149 |
|
| 11 | -578.271811 |
|
| 12 | -436.633742 |
|
| 13 | -253.460204 |
|
| 14 | -246.368513 |
|
| 15 | -103.683247 |
|
| 16 | -17.305825 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -15103.320073 |
|
-14825.346353 |
|
| 2 | -7867.934495 |
|
-8952.93903 |
|
| 3 | -4623.542066 |
|
-1338.533369 |
|
| 4 | -928.278156 |
|
-687.78851 |
|
| 5 | -755.815083 |
|
-574.913558 |
|
| 6 | -635.65391 |
|
-210.181696 |
|
| 7 | -541.171739 |
|
-169.6304 |
|
| 8 | -470.038883 |
|
-162.521907 |
|
| 9 | -408.946717 |
|
||
| 10 | -406.149485 |
|
||
| 11 | -315.818119 |
|
||
| 12 | -288.312296 |
|
||
| 13 | -263.422652 |
|
||
| 14 | -261.195654 |
|
||
| 15 | -113.635169 |
|
||
| 16 | -41.72927 |
|
||
| 17 | -11.482518 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -15474.807596 |
|
-18380.823673 |
|
| 2 | -8242.640625 |
|
-9595.896828 |
|
| 3 | -1916.688201 |
|
-2200.388793 |
|
| 4 | -868.604479 |
|
-328.326426 |
|
| 5 | -474.801756 |
|
-278.705167 |
|
| 6 | -213.038715 |
|
-145.323676 |
|
| 7 | -132.552986 |
|
-27.017229 |
|
| 8 | -127.740174 |
|
||
| 9 | -81.076649 |
|
||
| 10 | -79.399204 |
|
||
| 11 | -47.784595 |
|
||
| 12 | -33.346443 |
|
||
| 13 | -24.61351 |
|
||
| 14 | -22.081455 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 5.8e-185 |
|
| 3 | 2e-80 |
|
| 4 | 7.7e-44 |
|
| 5 | 4.4e-08 |
|
| 6 | 1.4e-08 |
|
| 7 | 1.2e-09 |
|
| 8 | 8.6 |
|
| 9 | 82.0 |
|
| 10 | 330.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 2.4e-205 |
|
0.0 |
|
| 3 | 8.5e-13 |
|
5e-12 |
|
| 4 | 1.9e-06 |
|
4.2e-08 |
|
| 5 | 0.0041 |
|
9.5 |
|
| 6 | 0.0031 |
|
440.0 |
|
| 7 | 1.6 |
|
470000.0 |
|
| 8 | 5.5 |
|
740000.0 |
|
| 9 | 1100.0 |
|
5200000.0 |
|
| 10 | 1400.0 |
|
5200000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 2.6e-146 |
|
0.0 |
|
| 3 | 1.2e-52 |
|
4.1e-96 |
|
| 4 | 0.016 |
|
17.0 |
|
| 5 | 21.0 |
|
410000.0 |
|
| 6 | 820.0 |
|
3000000.0 |
|
| 7 | 57000.0 |
|
3800000.0 |
|
| 8 | 1500.0 |
|
6000000.0 |
|
| 9 | 53000.0 |
|
5600000.0 |
|
| 10 | 150000.0 |
|
4400000.0 |
|