DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1542 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1982 |
|
| 6 | 1648 |
|
| 7 | 892 |
|
| 8 | 535 |
|
| 9 | 356 |
|
| 10 | 218 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 10238 |
|
4525 |
|
| 2 | 1147 |
|
1134 |
|
| 3 | 1355 |
|
701 |
|
| 4 | 120 |
|
||
| 5 | 16 |
|
||
| 6 | 1 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 9205 |
|
5117 |
|
| 2 | 1260 |
|
939 |
|
| 3 | 485 |
|
207 |
|
| 4 | 219 |
|
112 |
|
| 5 | 44 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -6028.910832 |
|
| 2 | -2687.813806 |
|
| 3 | -2468.924439 |
|
| 4 | -2248.715128 |
|
| 5 | -1476.719806 |
|
| 6 | -1258.930945 |
|
| 7 | -1211.912487 |
|
| 8 | -1191.269023 |
|
| 9 | -1069.292932 |
|
| 10 | -999.052671 |
|
| 11 | -882.520932 |
|
| 12 | -778.89042 |
|
| 13 | -743.108226 |
|
| 14 | -514.317863 |
|
| 15 | -399.823119 |
|
| 16 | -379.431767 |
|
| 17 | -317.350531 |
|
| 18 | -248.996488 |
|
| 19 | -227.433468 |
|
| 20 | -182.330302 |
|
| 21 | -173.429151 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -9823.379925 |
|
-13665.73756 |
|
| 2 | -8080.936686 |
|
-8342.489696 |
|
| 3 | -1674.983594 |
|
-6152.776722 |
|
| 4 | -1134.662657 |
|
-351.446586 |
|
| 5 | -904.772638 |
|
-191.718648 |
|
| 6 | -652.499912 |
|
-176.47583 |
|
| 7 | -608.233646 |
|
-154.183159 |
|
| 8 | -602.10614 |
|
-90.028739 |
|
| 9 | -589.876892 |
|
-47.206031 |
|
| 10 | -457.801277 |
|
-44.030415 |
|
| 11 | -399.424071 |
|
||
| 12 | -392.362562 |
|
||
| 13 | -342.252635 |
|
||
| 14 | -321.474039 |
|
||
| 15 | -188.62883 |
|
||
| 16 | -34.61441 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -9767.559937 |
|
-13006.227405 |
|
| 2 | -6814.910654 |
|
-10658.545984 |
|
| 3 | -2459.313277 |
|
-1830.368983 |
|
| 4 | -1351.094058 |
|
-341.655046 |
|
| 5 | -654.980971 |
|
-81.611477 |
|
| 6 | -651.030183 |
|
-21.486519 |
|
| 7 | -551.172078 |
|
||
| 8 | -420.856507 |
|
||
| 9 | -318.342501 |
|
||
| 10 | -302.534491 |
|
||
| 11 | -184.141407 |
|
||
| 12 | -180.89867 |
|
||
| 13 | -179.024806 |
|
||
| 14 | -119.891657 |
|
||
| 15 | -43.656889 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 4e-144 |
|
| 3 | 4.1e-57 |
|
| 4 | 3.8e-39 |
|
| 5 | 8.6e-12 |
|
| 6 | 5.9e-19 |
|
| 7 | 0.00011 |
|
| 8 | 2.8 |
|
| 9 | 35.0 |
|
| 10 | 890.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 8.4e-316 |
|
0.0 |
|
| 2 | 1.5e-147 |
|
2.4e-125 |
|
| 3 | 1.2e-62 |
|
1.2e-28 |
|
| 4 | 2.4e-43 |
|
3.8e-25 |
|
| 5 | 6e-40 |
|
5.3e-09 |
|
| 6 | 2.5e-36 |
|
5.1e-07 |
|
| 7 | 2e-15 |
|
0.0097 |
|
| 8 | 0.41 |
|
0.024 |
|
| 9 | 2.6 |
|
120000.0 |
|
| 10 | 20.0 |
|
880000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.3e-188 |
|
0.0 |
|
| 3 | 5.2e-66 |
|
1.6e-172 |
|
| 4 | 8.9e-46 |
|
4.2e-38 |
|
| 5 | 9.5e-26 |
|
4.7e-23 |
|
| 6 | 3.1e-20 |
|
2.0 |
|
| 7 | 2.5e-13 |
|
92.0 |
|
| 8 | 2e-05 |
|
8400.0 |
|
| 9 | 0.00033 |
|
4900000.0 |
|
| 10 | 1400.0 |
|
6700000.0 |
|