DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1446 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1871 |
|
| 6 | 1068 |
|
| 7 | 591 |
|
| 8 | 305 |
|
| 9 | 239 |
|
| 10 | 160 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 10856 |
|
5354 |
|
| 2 | 5199 |
|
1199 |
|
| 3 | 299 |
|
||
| 4 | 92 |
|
||
| 5 | 20 |
|
||
| 6 | 3 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 13566 |
|
5228 |
|
| 2 | 1107 |
|
1145 |
|
| 3 | 364 |
|
939 |
|
| 4 | 166 |
|
687 |
|
| 5 | 164 |
|
||
| 6 | 68 |
|
||
| 7 | 5 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -7705.344802 |
|
| 2 | -4356.442442 |
|
| 3 | -2754.804002 |
|
| 4 | -2010.319693 |
|
| 5 | -1528.887275 |
|
| 6 | -1473.892442 |
|
| 7 | -1395.16819 |
|
| 8 | -1278.610831 |
|
| 9 | -559.58113 |
|
| 10 | -434.023194 |
|
| 11 | -432.558155 |
|
| 12 | -232.554849 |
|
| 13 | -194.668738 |
|
| 14 | -185.463459 |
|
| 15 | -135.235927 |
|
| 16 | -121.826303 |
|
| 17 | -97.363524 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -12061.364047 |
|
-13571.628572 |
|
| 2 | -7754.419221 |
|
-9349.072953 |
|
| 3 | -1755.907154 |
|
-827.020015 |
|
| 4 | -1096.812004 |
|
-338.952642 |
|
| 5 | -1048.799884 |
|
-269.401536 |
|
| 6 | -1009.148556 |
|
-80.968546 |
|
| 7 | -971.441281 |
|
-42.95155 |
|
| 8 | -819.380078 |
|
-27.857485 |
|
| 9 | -733.861562 |
|
||
| 10 | -727.604636 |
|
||
| 11 | -604.068164 |
|
||
| 12 | -460.006392 |
|
||
| 13 | -436.996749 |
|
||
| 14 | -371.287304 |
|
||
| 15 | -348.12551 |
|
||
| 16 | -334.072157 |
|
||
| 17 | -305.901308 |
|
||
| 18 | -273.326857 |
|
||
| 19 | -204.12611 |
|
||
| 20 | -73.266794 |
|
||
| 21 | -55.297624 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -11980.869948 |
|
-13886.646143 |
|
| 2 | -7195.853391 |
|
-10970.764829 |
|
| 3 | -7033.347382 |
|
-7921.947579 |
|
| 4 | -374.038926 |
|
-503.863712 |
|
| 5 | -321.159416 |
|
-347.407782 |
|
| 6 | -312.200214 |
|
-330.677661 |
|
| 7 | -182.411366 |
|
-171.327345 |
|
| 8 | -126.675156 |
|
-108.681432 |
|
| 9 | -126.234701 |
|
-101.428317 |
|
| 10 | -99.68127 |
|
-78.516504 |
|
| 11 | -54.34249 |
|
-11.235671 |
|
| 12 | -43.775396 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 9.8e-153 |
|
| 3 | 8.3e-55 |
|
| 4 | 2.5e-38 |
|
| 5 | 1.2e-26 |
|
| 6 | 1e-13 |
|
| 7 | 1.6e-12 |
|
| 8 | 4.8e-05 |
|
| 9 | 4.3e-09 |
|
| 10 | 0.0052 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 6.3e-199 |
|
0.0 |
|
| 3 | 8.2e-92 |
|
4.9e-28 |
|
| 4 | 2e-23 |
|
5.4e-16 |
|
| 5 | 5.7e-08 |
|
15.0 |
|
| 6 | 2.9e-06 |
|
2100.0 |
|
| 7 | 1.3e-05 |
|
60000.0 |
|
| 8 | 0.00016 |
|
520000.0 |
|
| 9 | 0.0049 |
|
560000.0 |
|
| 10 | 0.054 |
|
640000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 7.2e-320 |
|
0.0 |
|
| 2 | 6.9e-209 |
|
0.0 |
|
| 3 | 8.4e-157 |
|
2.2e-254 |
|
| 4 | 8.3e-06 |
|
0.0014 |
|
| 5 | 0.31 |
|
50000.0 |
|
| 6 | 5.6 |
|
220000.0 |
|
| 7 | 7.8 |
|
2200000.0 |
|
| 8 | 46.0 |
|
2400000.0 |
|
| 9 | 550.0 |
|
3800000.0 |
|
| 10 | 1400.0 |
|
4600000.0 |
|