DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1488 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1987 |
|
| 6 | 1515 |
|
| 7 | 874 |
|
| 8 | 136 |
|
| 9 | 66 |
|
| 10 | 40 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 10736 |
|
6027 |
|
| 2 | 5607 |
|
1135 |
|
| 3 | 504 |
|
||
| 4 | 131 |
|
||
| 5 | 43 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 13273 |
|
9970 |
|
| 2 | 770 |
|
1460 |
|
| 3 | 513 |
|
271 |
|
| 4 | 56 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -9785.108998 |
|
| 2 | -6103.341262 |
|
| 3 | -3208.93059 |
|
| 4 | -2892.34727 |
|
| 5 | -1744.261301 |
|
| 6 | -1530.918462 |
|
| 7 | -1461.804928 |
|
| 8 | -1232.57373 |
|
| 9 | -952.915931 |
|
| 10 | -555.314896 |
|
| 11 | -437.548378 |
|
| 12 | -336.132219 |
|
| 13 | -268.8306 |
|
| 14 | -267.250246 |
|
| 15 | -229.819202 |
|
| 16 | -177.125249 |
|
| 17 | -171.376593 |
|
| 18 | -166.632421 |
|
| 19 | -130.894154 |
|
| 20 | -126.833828 |
|
| 21 | -114.73652 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -14217.565723 |
|
-18373.478677 |
|
| 2 | -8566.014704 |
|
-10333.680985 |
|
| 3 | -1077.920758 |
|
-4735.375477 |
|
| 4 | -1038.57789 |
|
-535.581089 |
|
| 5 | -828.305899 |
|
-513.889472 |
|
| 6 | -632.486254 |
|
-425.10572 |
|
| 7 | -523.710957 |
|
-287.678667 |
|
| 8 | -452.883407 |
|
-210.820398 |
|
| 9 | -392.726429 |
|
||
| 10 | -288.585077 |
|
||
| 11 | -288.585077 |
|
||
| 12 | -283.125285 |
|
||
| 13 | -218.918571 |
|
||
| 14 | -208.474248 |
|
||
| 15 | -174.777048 |
|
||
| 16 | -77.290254 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -16441.417511 |
|
-18497.472152 |
|
| 2 | -8929.261612 |
|
-10598.209301 |
|
| 3 | -3936.928762 |
|
-6450.124964 |
|
| 4 | -1109.554873 |
|
-4903.939059 |
|
| 5 | -582.545087 |
|
-2286.102832 |
|
| 6 | -528.349828 |
|
-270.317323 |
|
| 7 | -282.443782 |
|
-182.682194 |
|
| 8 | -202.763634 |
|
-160.301946 |
|
| 9 | -202.763634 |
|
-61.806033 |
|
| 10 | -136.467994 |
|
-55.324757 |
|
| 11 | -132.625124 |
|
||
| 12 | -28.224213 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 4.1e-304 |
|
| 3 | 3.2e-266 |
|
| 4 | 2.8e-51 |
|
| 5 | 5.5e-46 |
|
| 6 | 2.6e-11 |
|
| 7 | 2.2e-06 |
|
| 8 | 2.3e-05 |
|
| 9 | 3.1e-05 |
|
| 10 | 2.1 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 2.4e-275 |
|
0.0 |
|
| 3 | 1.5e-58 |
|
5.6e-08 |
|
| 4 | 8.5e-30 |
|
5.2e-05 |
|
| 5 | 5.8e-14 |
|
0.018 |
|
| 6 | 2.3e-05 |
|
210000.0 |
|
| 7 | 0.00054 |
|
210000.0 |
|
| 8 | 0.5 |
|
210000.0 |
|
| 9 | 11.0 |
|
290000.0 |
|
| 10 | 71.0 |
|
1300000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 2e-233 |
|
0.0 |
|
| 3 | 7e-211 |
|
1.2e-30 |
|
| 4 | 2.2e-13 |
|
1.6e-30 |
|
| 5 | 1.1e-06 |
|
0.0028 |
|
| 6 | 28.0 |
|
130000.0 |
|
| 7 | 5400.0 |
|
290000.0 |
|
| 8 | 88000.0 |
|
990000.0 |
|
| 9 | 150000.0 |
|
3300000.0 |
|
| 10 | 480000.0 |
|
4100000.0 |
|