DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1429 |
|
| 2 | 1999 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1895 |
|
| 6 | 1087 |
|
| 7 | 595 |
|
| 8 | 291 |
|
| 9 | 149 |
|
| 10 | 111 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 5707 |
|
3903 |
|
| 2 | 2160 |
|
865 |
|
| 3 | 271 |
|
||
| 4 | 118 |
|
||
| 5 | 41 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 6687 |
|
5232 |
|
| 2 | 1367 |
|
835 |
|
| 3 | 303 |
|
||
| 4 | 1 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -6635.449478 |
|
| 2 | -4724.781643 |
|
| 3 | -1106.584915 |
|
| 4 | -585.846465 |
|
| 5 | -522.470961 |
|
| 6 | -476.934966 |
|
| 7 | -401.461203 |
|
| 8 | -396.442218 |
|
| 9 | -362.647259 |
|
| 10 | -335.591834 |
|
| 11 | -240.413865 |
|
| 12 | -223.592911 |
|
| 13 | -215.115284 |
|
| 14 | -89.174497 |
|
| 15 | -87.154063 |
|
| 16 | -74.288764 |
|
| 17 | -71.396674 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -9479.539535 |
|
-10924.183127 |
|
| 2 | -7031.163946 |
|
-9096.984887 |
|
| 3 | -1136.10041 |
|
-793.536096 |
|
| 4 | -1063.111824 |
|
-715.797907 |
|
| 5 | -227.733804 |
|
-156.554051 |
|
| 6 | -170.094144 |
|
-54.936515 |
|
| 7 | -152.320446 |
|
-19.893563 |
|
| 8 | -147.487641 |
|
||
| 9 | -99.754739 |
|
||
| 10 | -86.973509 |
|
||
| 11 | -86.095609 |
|
||
| 12 | -24.684383 |
|
||
| 13 | -19.6729 |
|
||
| 14 | -17.814258 |
|
||
| 15 | -10.644813 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -10958.86223 |
|
-10984.794114 |
|
| 2 | -6318.376627 |
|
-8044.255123 |
|
| 3 | -1204.539541 |
|
-211.762511 |
|
| 4 | -389.349632 |
|
-116.651374 |
|
| 5 | -183.876748 |
|
-45.471274 |
|
| 6 | -146.777571 |
|
-25.411729 |
|
| 7 | -127.393679 |
|
-17.575647 |
|
| 8 | -107.877151 |
|
-17.575647 |
|
| 9 | -90.131569 |
|
||
| 10 | -76.771202 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 3.1e-303 |
|
| 3 | 1.6e-25 |
|
| 4 | 1.9e-28 |
|
| 5 | 1.3e-17 |
|
| 6 | 3.1e-12 |
|
| 7 | 7.6e-11 |
|
| 8 | 2.3e-09 |
|
| 9 | 0.0013 |
|
| 10 | 0.036 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 9e-312 |
|
0.0 |
|
| 3 | 4.1e-46 |
|
1.1e-55 |
|
| 4 | 2.6e-13 |
|
45.0 |
|
| 5 | 2.6e-10 |
|
510.0 |
|
| 6 | 1.9e-08 |
|
680000.0 |
|
| 7 | 0.52 |
|
1500000.0 |
|
| 8 | 4.4 |
|
1500000.0 |
|
| 9 | 280.0 |
|
1900000.0 |
|
| 10 | 240.0 |
|
2700000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 2e-301 |
|
0.0 |
|
| 3 | 1.6e-77 |
|
1.6e-49 |
|
| 4 | 9.3e-75 |
|
110.0 |
|
| 5 | 0.067 |
|
36000.0 |
|
| 6 | 97.0 |
|
200000.0 |
|
| 7 | 53000.0 |
|
210000.0 |
|
| 8 | 28000.0 |
|
300000.0 |
|
| 9 | 230000.0 |
|
150000.0 |
|
| 10 | 820000.0 |
|
1000000.0 |
|