DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1992 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1977 |
|
| 5 | 1429 |
|
| 6 | 943 |
|
| 7 | 456 |
|
| 8 | 293 |
|
| 9 | 221 |
|
| 10 | 139 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 4984 |
|
3066 |
|
| 2 | 982 |
|
549 |
|
| 3 | 191 |
|
187 |
|
| 4 | 150 |
|
122 |
|
| 5 | 15 |
|
15 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 6268 |
|
2994 |
|
| 2 | 786 |
|
637 |
|
| 3 | 219 |
|
152 |
|
| 4 | 76 |
|
55 |
|
| 5 | 2 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -5361.01426 |
|
| 2 | -2774.701568 |
|
| 3 | -1126.126432 |
|
| 4 | -826.942061 |
|
| 5 | -609.125961 |
|
| 6 | -540.727077 |
|
| 7 | -501.320098 |
|
| 8 | -408.165611 |
|
| 9 | -345.509108 |
|
| 10 | -334.558132 |
|
| 11 | -332.167286 |
|
| 12 | -271.069279 |
|
| 13 | -225.836819 |
|
| 14 | -177.62895 |
|
| 15 | -137.421893 |
|
| 16 | -127.892157 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -7533.389989 |
|
-11499.881527 |
|
| 2 | -6625.81213 |
|
-7280.886325 |
|
| 3 | -4014.888029 |
|
-1536.993912 |
|
| 4 | -2067.217271 |
|
-1466.216651 |
|
| 5 | -208.53995 |
|
-136.099415 |
|
| 6 | -126.113845 |
|
-64.891885 |
|
| 7 | -113.881885 |
|
-59.101692 |
|
| 8 | -81.736287 |
|
-55.840619 |
|
| 9 | -68.564257 |
|
-11.199178 |
|
| 10 | -55.674893 |
|
||
| 11 | -49.093079 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -7302.098357 |
|
-10216.619936 |
|
| 2 | -7268.719385 |
|
-7129.98307 |
|
| 3 | -208.347558 |
|
-357.112504 |
|
| 4 | -171.445359 |
|
-113.016833 |
|
| 5 | -167.428205 |
|
-72.343132 |
|
| 6 | -147.573009 |
|
-67.491514 |
|
| 7 | -99.827644 |
|
-67.491514 |
|
| 8 | -97.287368 |
|
-50.201372 |
|
| 9 | -51.641027 |
|
||
| 10 | -5.877331 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 5.7e-147 |
|
| 3 | 5.2e-68 |
|
| 4 | 3.2e-16 |
|
| 5 | 9.2e-14 |
|
| 6 | 2.3e-06 |
|
| 7 | 5.3e-06 |
|
| 8 | 1.7e-05 |
|
| 9 | 630.0 |
|
| 10 | 1100.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 0.0 |
|
0.0 |
|
| 3 | 6.1e-117 |
|
5.4e-186 |
|
| 4 | 2.3e-27 |
|
15000.0 |
|
| 5 | 7.3 |
|
150000.0 |
|
| 6 | 20.0 |
|
830000.0 |
|
| 7 | 2400.0 |
|
2500000.0 |
|
| 8 | 13000.0 |
|
3000000.0 |
|
| 9 | 46000.0 |
|
3000000.0 |
|
| 10 | 240000.0 |
|
1100000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 7.1e-280 |
|
0.0 |
|
| 3 | 18.0 |
|
3.2e-65 |
|
| 4 | 0.14 |
|
8100.0 |
|
| 5 | 7200.0 |
|
59000.0 |
|
| 6 | 420000.0 |
|
760000.0 |
|
| 7 | 420000.0 |
|
1800000.0 |
|
| 8 | 410000.0 |
|
2000000.0 |
|
| 9 | 420000.0 |
|
3500000.0 |
|
| 10 | 690000.0 |
|
3600000.0 |
|