DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1529 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1722 |
|
| 6 | 1088 |
|
| 7 | 658 |
|
| 8 | 334 |
|
| 9 | 38 |
|
| 10 | 18 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 5315 |
|
3381 |
|
| 2 | 1195 |
|
535 |
|
| 3 | 451 |
|
||
| 4 | 90 |
|
||
| 5 | 9 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 5180 |
|
3873 |
|
| 2 | 617 |
|
188 |
|
| 3 | 147 |
|
78 |
|
| 4 | 33 |
|
16 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -9251.008099 |
|
| 2 | -5602.815969 |
|
| 3 | -914.120498 |
|
| 4 | -833.258281 |
|
| 5 | -718.499426 |
|
| 6 | -636.589445 |
|
| 7 | -454.754426 |
|
| 8 | -324.285181 |
|
| 9 | -181.382378 |
|
| 10 | -144.108884 |
|
| 11 | -125.382403 |
|
| 12 | -66.858111 |
|
| 13 | -61.70284 |
|
| 14 | -58.297794 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -8848.602276 |
|
-10883.816934 |
|
| 2 | -6008.149467 |
|
-10654.335165 |
|
| 3 | -1757.528312 |
|
-5843.200641 |
|
| 4 | -839.261127 |
|
-195.806106 |
|
| 5 | -265.294695 |
|
-150.693884 |
|
| 6 | -88.376105 |
|
-67.547509 |
|
| 7 | -63.076107 |
|
-43.456477 |
|
| 8 | -51.95242 |
|
||
| 9 | -35.411621 |
|
||
| 10 | -11.338435 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -8956.006352 |
|
-12332.903464 |
|
| 2 | -8258.344409 |
|
-9467.856653 |
|
| 3 | -4224.931199 |
|
-1826.704493 |
|
| 4 | -116.373247 |
|
-171.553483 |
|
| 5 | -99.968189 |
|
-105.254229 |
|
| 6 | -97.06283 |
|
-93.514539 |
|
| 7 | -94.056688 |
|
-67.193877 |
|
| 8 | -51.759438 |
|
-3.340072 |
|
| 9 | -15.56351 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 0.0 |
|
| 3 | 1.8e-62 |
|
| 4 | 3.3e-50 |
|
| 5 | 3.7e-06 |
|
| 6 | 8.4e-05 |
|
| 7 | 0.023 |
|
| 8 | 5.3e-05 |
|
| 9 | 0.023 |
|
| 10 | 6.3 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 0.0 |
|
0.0 |
|
| 3 | 1.2e-24 |
|
7.4e-06 |
|
| 4 | 2.8e-07 |
|
0.13 |
|
| 5 | 0.78 |
|
710000.0 |
|
| 6 | 1700.0 |
|
2600000.0 |
|
| 7 | 160.0 |
|
2700000.0 |
|
| 8 | 5000.0 |
|
3800000.0 |
|
| 9 | 5700.0 |
|
3900000.0 |
|
| 10 | 68000.0 |
|
4200000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 3.1e-294 |
|
0.0 |
|
| 3 | 3.9e-37 |
|
5.2 |
|
| 4 | 1.1e-11 |
|
2400000.0 |
|
| 5 | 92.0 |
|
4500000.0 |
|
| 6 | 8400.0 |
|
4500000.0 |
|
| 7 | 110000.0 |
|
4600000.0 |
|
| 8 | 460000.0 |
|
4500000.0 |
|
| 9 | 630000.0 |
|
9100000.0 |
|
| 10 | 820000.0 |
|
8500000.0 |
|