DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1830 |
|
| 5 | 984 |
|
| 6 | 638 |
|
| 7 | 309 |
|
| 8 | 168 |
|
| 9 | 75 |
|
| 10 | 64 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 2396 |
|
2249 |
|
| 2 | 1034 |
|
174 |
|
| 3 | 64 |
|
||
| 4 | 5 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 1680 |
|
1172 |
|
| 2 | 795 |
|
641 |
|
| 3 | 183 |
|
164 |
|
| 4 | 59 |
|
29 |
|
| 5 | 3 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -5909.719774 |
|
| 2 | -2660.849174 |
|
| 3 | -447.74987 |
|
| 4 | -427.114578 |
|
| 5 | -423.472887 |
|
| 6 | -414.63324 |
|
| 7 | -380.632066 |
|
| 8 | -305.576177 |
|
| 9 | -274.342879 |
|
| 10 | -241.32916 |
|
| 11 | -191.981503 |
|
| 12 | -142.063881 |
|
| 13 | -125.486291 |
|
| 14 | -58.241622 |
|
| 15 | -52.690756 |
|
| 16 | -50.47279 |
|
| 17 | -28.490711 |
|
| 18 | -18.800155 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -6118.242538 |
|
-8591.093269 |
|
| 2 | -5875.788956 |
|
-8360.434703 |
|
| 3 | -432.74553 |
|
-2258.675394 |
|
| 4 | -73.291536 |
|
-121.686147 |
|
| 5 | -72.585387 |
|
-84.910959 |
|
| 6 | -59.743336 |
|
-31.420331 |
|
| 7 | -59.743336 |
|
-3.858905 |
|
| 8 | -39.474212 |
|
||
| 9 | -30.720033 |
|
||
| 10 | -22.951005 |
|
||
| 11 | -17.735641 |
|
||
| 12 | -17.687422 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -7297.853534 |
|
-5704.31109 |
|
| 2 | -6577.672656 |
|
-4297.554318 |
|
| 3 | -2560.537541 |
|
-600.691598 |
|
| 4 | -1489.853483 |
|
-76.669678 |
|
| 5 | -146.46192 |
|
-72.285224 |
|
| 6 | -98.508411 |
|
-63.716332 |
|
| 7 | -89.887848 |
|
-62.790396 |
|
| 8 | -78.540091 |
|
-48.206763 |
|
| 9 | -59.404534 |
|
-47.287005 |
|
| 10 | -57.614255 |
|
-47.287005 |
|
| 11 | -39.228804 |
|
-37.928672 |
|
| 12 | -8.448463 |
|
-31.700201 |
|
| 13 | -22.684231 |
|
||
| 14 | -17.636427 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 1.8e-195 |
|
| 3 | 3e-62 |
|
| 4 | 6.8e-27 |
|
| 5 | 3.1e-10 |
|
| 6 | 1.1e-14 |
|
| 7 | 4.2e-10 |
|
| 8 | 0.0001 |
|
| 9 | 9.7e-05 |
|
| 10 | 0.014 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 0.0 |
|
0.0 |
|
| 3 | 6.1e-99 |
|
1500.0 |
|
| 4 | 9e-23 |
|
250000.0 |
|
| 5 | 0.0006 |
|
780000.0 |
|
| 6 | 40.0 |
|
1700000.0 |
|
| 7 | 230.0 |
|
2600000.0 |
|
| 8 | 420.0 |
|
2800000.0 |
|
| 9 | 7900.0 |
|
3100000.0 |
|
| 10 | 72000.0 |
|
3300000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 0.0 |
|
4.8e-115 |
|
| 3 | 25.0 |
|
5.8e-77 |
|
| 4 | 2100.0 |
|
1.9e-13 |
|
| 5 | 6400.0 |
|
0.16 |
|
| 6 | 23000.0 |
|
0.84 |
|
| 7 | 91000.0 |
|
690.0 |
|
| 8 | 57000.0 |
|
460.0 |
|
| 9 | 8600.0 |
|
610.0 |
|
| 10 | 100000.0 |
|
1800.0 |
|