DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1571 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1980 |
|
| 6 | 1624 |
|
| 7 | 943 |
|
| 8 | 469 |
|
| 9 | 345 |
|
| 10 | 213 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 13003 |
|
8964 |
|
| 2 | 1521 |
|
1605 |
|
| 3 | 340 |
|
560 |
|
| 4 | 153 |
|
||
| 5 | 37 |
|
||
| 6 | 19 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 13567 |
|
12480 |
|
| 2 | 1934 |
|
2560 |
|
| 3 | 432 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -15445.517063 |
|
| 2 | -7210.19341 |
|
| 3 | -2489.098915 |
|
| 4 | -1457.705005 |
|
| 5 | -1403.33015 |
|
| 6 | -1031.647329 |
|
| 7 | -578.179262 |
|
| 8 | -553.696846 |
|
| 9 | -518.612518 |
|
| 10 | -400.734397 |
|
| 11 | -322.715568 |
|
| 12 | -271.254992 |
|
| 13 | -257.047477 |
|
| 14 | -241.116882 |
|
| 15 | -203.543657 |
|
| 16 | -198.687722 |
|
| 17 | -198.121269 |
|
| 18 | -194.683796 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -17580.373824 |
|
-27032.69135 |
|
| 2 | -10005.967621 |
|
-13846.5258 |
|
| 3 | -7694.725655 |
|
-2783.623227 |
|
| 4 | -873.492186 |
|
-934.655043 |
|
| 5 | -823.075303 |
|
-259.311489 |
|
| 6 | -823.075303 |
|
-190.796577 |
|
| 7 | -630.225665 |
|
-59.527897 |
|
| 8 | -399.271388 |
|
-11.189443 |
|
| 9 | -276.578325 |
|
||
| 10 | -271.168326 |
|
||
| 11 | -255.037262 |
|
||
| 12 | -183.210787 |
|
||
| 13 | -161.820529 |
|
||
| 14 | -91.866684 |
|
||
| 15 | -80.948888 |
|
||
| 16 | -48.217968 |
|
||
| 17 | -46.40772 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -20589.300931 |
|
-23092.430352 |
|
| 2 | -10602.413188 |
|
-15149.325378 |
|
| 3 | -9718.552514 |
|
-12973.265712 |
|
| 4 | -558.254949 |
|
-290.069189 |
|
| 5 | -347.207258 |
|
-268.508524 |
|
| 6 | -146.926533 |
|
-160.078633 |
|
| 7 | -132.713478 |
|
-150.250028 |
|
| 8 | -108.244532 |
|
-102.793268 |
|
| 9 | -61.609879 |
|
-91.52335 |
|
| 10 | -24.315216 |
|
-50.724574 |
|
| 11 | -20.979026 |
|
-20.750423 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 0.0 |
|
| 3 | 8.6e-82 |
|
| 4 | 2e-28 |
|
| 5 | 3.1e-23 |
|
| 6 | 1.1e-09 |
|
| 7 | 3.8e-06 |
|
| 8 | 0.0017 |
|
| 9 | 5.4e-09 |
|
| 10 | 9.8 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.2e-235 |
|
0.0 |
|
| 3 | 5.5e-40 |
|
9.4e-17 |
|
| 4 | 1.4e-25 |
|
1.2e-13 |
|
| 5 | 8.7e-09 |
|
1.3 |
|
| 6 | 9e-08 |
|
36.0 |
|
| 7 | 7.8e-07 |
|
1600000.0 |
|
| 8 | 0.00037 |
|
1000000.0 |
|
| 9 | 5.5 |
|
2600000.0 |
|
| 10 | 260.0 |
|
5400000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 2e-267 |
|
0.0 |
|
| 3 | 1e-29 |
|
1.6e-07 |
|
| 4 | 0.082 |
|
0.094 |
|
| 5 | 0.32 |
|
0.24 |
|
| 6 | 1500.0 |
|
16.0 |
|
| 7 | 7200.0 |
|
5300.0 |
|
| 8 | 4000.0 |
|
13000.0 |
|
| 9 | 85000.0 |
|
830000.0 |
|
| 10 | 170000.0 |
|
910000.0 |
|