DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1999 |
|
| 5 | 1763 |
|
| 6 | 1076 |
|
| 7 | 419 |
|
| 8 | 264 |
|
| 9 | 180 |
|
| 10 | 87 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 10577 |
|
5872 |
|
| 2 | 3154 |
|
1237 |
|
| 3 | 47 |
|
580 |
|
| 4 | 137 |
|
||
| 5 | 15 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 8109 |
|
6032 |
|
| 2 | 1510 |
|
1773 |
|
| 3 | 914 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -4007.686536 |
|
| 2 | -3417.468988 |
|
| 3 | -3273.854015 |
|
| 4 | -2210.036931 |
|
| 5 | -2202.435822 |
|
| 6 | -1630.120293 |
|
| 7 | -1580.984544 |
|
| 8 | -942.380855 |
|
| 9 | -882.311428 |
|
| 10 | -849.708961 |
|
| 11 | -736.643805 |
|
| 12 | -405.868609 |
|
| 13 | -388.584266 |
|
| 14 | -387.307305 |
|
| 15 | -319.954923 |
|
| 16 | -282.536397 |
|
| 17 | -244.218229 |
|
| 18 | -217.686063 |
|
| 19 | -183.66615 |
|
| 20 | -177.296491 |
|
| 21 | -147.768074 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -7704.466988 |
|
-9946.820753 |
|
| 2 | -7238.20717 |
|
-9533.921133 |
|
| 3 | -1019.363426 |
|
-4292.644432 |
|
| 4 | -893.460573 |
|
-956.027914 |
|
| 5 | -865.230149 |
|
-906.390288 |
|
| 6 | -629.176575 |
|
-416.363345 |
|
| 7 | -514.667026 |
|
-318.113956 |
|
| 8 | -501.950448 |
|
-215.930994 |
|
| 9 | -477.519967 |
|
-189.499179 |
|
| 10 | -465.648953 |
|
-101.066673 |
|
| 11 | -447.922485 |
|
-65.095253 |
|
| 12 | -412.769447 |
|
-21.017258 |
|
| 13 | -366.562559 |
|
-18.146893 |
|
| 14 | -341.666943 |
|
||
| 15 | -338.761322 |
|
||
| 16 | -293.414726 |
|
||
| 17 | -138.091789 |
|
||
| 18 | -103.77721 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -8783.555731 |
|
-9080.823034 |
|
| 2 | -8132.814461 |
|
-8706.471142 |
|
| 3 | -6932.720276 |
|
-4218.094578 |
|
| 4 | -3263.255192 |
|
-773.183904 |
|
| 5 | -336.946129 |
|
-740.837488 |
|
| 6 | -289.014866 |
|
-315.434566 |
|
| 7 | -198.417636 |
|
-204.448229 |
|
| 8 | -147.877385 |
|
-21.140027 |
|
| 9 | -139.216538 |
|
-5.022026 |
|
| 10 | -118.801208 |
|
||
| 11 | -66.300881 |
|
||
| 12 | -60.661981 |
|
||
| 13 | -43.701669 |
|
||
| 14 | -39.756739 |
|
||
| 15 | -21.276504 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 1.1e-307 |
|
| 2 | 5.1e-96 |
|
| 3 | 2.8e-43 |
|
| 4 | 1.4e-41 |
|
| 5 | 1.4e-23 |
|
| 6 | 2.9e-20 |
|
| 7 | 2.4e-12 |
|
| 8 | 9.8e-12 |
|
| 9 | 7.1e-08 |
|
| 10 | 0.08 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 8.4e-321 |
|
0.0 |
|
| 2 | 1.1e-201 |
|
0.0 |
|
| 3 | 4.1e-60 |
|
0.0 |
|
| 4 | 3.3e-53 |
|
1.7e-10 |
|
| 5 | 7.2e-34 |
|
1.1e-09 |
|
| 6 | 2.1e-33 |
|
0.00014 |
|
| 7 | 2.2e-06 |
|
0.01 |
|
| 8 | 3.5e-05 |
|
22.0 |
|
| 9 | 0.00055 |
|
23000.0 |
|
| 10 | 11.0 |
|
31000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 0.0 |
|
0.0 |
|
| 3 | 3e-69 |
|
2.5e-87 |
|
| 4 | 2e-51 |
|
2.9e-43 |
|
| 5 | 2.2e-17 |
|
2.6e-05 |
|
| 6 | 1.2e-06 |
|
1800.0 |
|
| 7 | 0.51 |
|
23000.0 |
|
| 8 | 74.0 |
|
30000.0 |
|
| 9 | 1500.0 |
|
1800000.0 |
|
| 10 | 29000.0 |
|
1800000.0 |
|