DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1273 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1970 |
|
| 6 | 1684 |
|
| 7 | 1044 |
|
| 8 | 570 |
|
| 9 | 369 |
|
| 10 | 216 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 6355 |
|
4805 |
|
| 2 | 2995 |
|
1139 |
|
| 3 | 608 |
|
156 |
|
| 4 | 93 |
|
||
| 5 | 19 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 4718 |
|
4510 |
|
| 2 | 1175 |
|
1119 |
|
| 3 | 425 |
|
202 |
|
| 4 | 412 |
|
35 |
|
| 5 | 31 |
|
||
| 6 | 13 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -7005.258646 |
|
| 2 | -4048.303924 |
|
| 3 | -1002.464476 |
|
| 4 | -791.054433 |
|
| 5 | -784.85976 |
|
| 6 | -733.363608 |
|
| 7 | -570.242701 |
|
| 8 | -460.547847 |
|
| 9 | -406.488534 |
|
| 10 | -352.506251 |
|
| 11 | -320.740945 |
|
| 12 | -283.601601 |
|
| 13 | -272.243665 |
|
| 14 | -248.88475 |
|
| 15 | -246.496128 |
|
| 16 | -237.329946 |
|
| 17 | -231.724489 |
|
| 18 | -196.094311 |
|
| 19 | -166.236432 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -10649.93644 |
|
-16149.982921 |
|
| 2 | -9400.294445 |
|
-10714.490642 |
|
| 3 | -2543.610424 |
|
-3653.315121 |
|
| 4 | -1445.782336 |
|
-900.452013 |
|
| 5 | -535.127499 |
|
-426.113624 |
|
| 6 | -439.06611 |
|
-312.29173 |
|
| 7 | -405.149953 |
|
-173.590296 |
|
| 8 | -251.240866 |
|
-105.159023 |
|
| 9 | -207.969797 |
|
-100.502797 |
|
| 10 | -203.071945 |
|
-82.256946 |
|
| 11 | -156.433387 |
|
-63.345347 |
|
| 12 | -143.68465 |
|
-60.429119 |
|
| 13 | -136.568697 |
|
-14.729646 |
|
| 14 | -92.352239 |
|
||
| 15 | -80.219081 |
|
||
| 16 | -33.166426 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -10732.919453 |
|
-13195.098348 |
|
| 2 | -8773.639409 |
|
-8873.715502 |
|
| 3 | -3315.680633 |
|
-3351.468784 |
|
| 4 | -1376.351694 |
|
-1268.81404 |
|
| 5 | -830.80707 |
|
-1041.562452 |
|
| 6 | -260.152913 |
|
-930.261649 |
|
| 7 | -165.315893 |
|
-516.693761 |
|
| 8 | -107.826381 |
|
-457.253763 |
|
| 9 | -69.927368 |
|
-341.759674 |
|
| 10 | -34.931137 |
|
-258.700137 |
|
| 11 | -14.996951 |
|
-231.832931 |
|
| 12 | -13.616495 |
|
-226.514644 |
|
| 13 | -6.081068 |
|
-119.969366 |
|
| 14 | -105.969564 |
|
||
| 15 | -14.84872 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 5.4e-132 |
|
| 3 | 7.7e-82 |
|
| 4 | 2.6e-73 |
|
| 5 | 8.9e-61 |
|
| 6 | 8.6e-59 |
|
| 7 | 1.2e-41 |
|
| 8 | 9.4e-39 |
|
| 9 | 3e-33 |
|
| 10 | 5.8e-14 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 5.7e-137 |
|
0.0 |
|
| 3 | 2e-96 |
|
5.4e-183 |
|
| 4 | 2.9e-73 |
|
2.9e-15 |
|
| 5 | 8.4e-66 |
|
17000.0 |
|
| 6 | 7.6e-15 |
|
68000.0 |
|
| 7 | 2.5e-07 |
|
740000.0 |
|
| 8 | 0.00041 |
|
860000.0 |
|
| 9 | 24.0 |
|
940000.0 |
|
| 10 | 370.0 |
|
1300000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.9e-153 |
|
0.0 |
|
| 3 | 2.2e-134 |
|
2.4e-190 |
|
| 4 | 2.2e-64 |
|
5e-99 |
|
| 5 | 3.3e-35 |
|
1.2e-39 |
|
| 6 | 5.6e-21 |
|
3100.0 |
|
| 7 | 9.9e-08 |
|
190000.0 |
|
| 8 | 9.9e-08 |
|
560000.0 |
|
| 9 | 0.00091 |
|
300000.0 |
|
| 10 | 0.011 |
|
820000.0 |
|