DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1994 |
|
| 5 | 1554 |
|
| 6 | 946 |
|
| 7 | 487 |
|
| 8 | 286 |
|
| 9 | 136 |
|
| 10 | 83 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 11828 |
|
11954 |
|
| 2 | 2287 |
|
1188 |
|
| 3 | 21 |
|
181 |
|
| 4 | 319 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 10624 |
|
12195 |
|
| 2 | 1858 |
|
2398 |
|
| 3 | 177 |
|
272 |
|
| 4 | 26 |
|
65 |
|
| 5 | 1 |
|
20 |
|
| 6 | 7 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -6272.050874 |
|
| 2 | -5031.952453 |
|
| 3 | -4929.179037 |
|
| 4 | -3872.580922 |
|
| 5 | -3590.110322 |
|
| 6 | -3282.341343 |
|
| 7 | -2188.469249 |
|
| 8 | -1927.874155 |
|
| 9 | -1772.232493 |
|
| 10 | -1556.590688 |
|
| 11 | -1438.41642 |
|
| 12 | -1246.199226 |
|
| 13 | -740.01038 |
|
| 14 | -600.497816 |
|
| 15 | -573.780626 |
|
| 16 | -460.392525 |
|
| 17 | -455.657747 |
|
| 18 | -202.10125 |
|
| 19 | -105.604466 |
|
| 20 | -100.131595 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -5710.574317 |
|
-7642.208239 |
|
| 2 | -4798.633767 |
|
-6562.793747 |
|
| 3 | -1280.41518 |
|
-1426.598376 |
|
| 4 | -1178.787995 |
|
-562.355139 |
|
| 5 | -988.019798 |
|
-385.982402 |
|
| 6 | -803.497683 |
|
-372.571 |
|
| 7 | -727.062988 |
|
-369.255637 |
|
| 8 | -657.929763 |
|
-366.620607 |
|
| 9 | -595.922038 |
|
-337.704722 |
|
| 10 | -511.802474 |
|
-314.948868 |
|
| 11 | -505.539285 |
|
-220.311709 |
|
| 12 | -497.495257 |
|
-147.53853 |
|
| 13 | -492.553341 |
|
-102.581825 |
|
| 14 | -480.577143 |
|
-44.998151 |
|
| 15 | -469.279931 |
|
-26.612792 |
|
| 16 | -446.168474 |
|
||
| 17 | -314.135713 |
|
||
| 18 | -251.261566 |
|
||
| 19 | -181.722258 |
|
||
| 20 | -64.57793 |
|
||
| 21 | -53.363439 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -8126.853461 |
|
-15691.227942 |
|
| 2 | -5918.159001 |
|
-8452.367061 |
|
| 3 | -5058.403155 |
|
-7143.784521 |
|
| 4 | -3674.01601 |
|
-6493.605634 |
|
| 5 | -2495.085298 |
|
-4470.889662 |
|
| 6 | -1268.731271 |
|
-1077.604646 |
|
| 7 | -937.637097 |
|
-1076.818914 |
|
| 8 | -347.521843 |
|
-195.390977 |
|
| 9 | -282.257065 |
|
-175.463971 |
|
| 10 | -216.493671 |
|
-4.159447 |
|
| 11 | -146.075815 |
|
||
| 12 | -146.075815 |
|
||
| 13 | -116.511045 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 3.9e-67 |
|
| 2 | 5.2e-66 |
|
| 3 | 1.5e-35 |
|
| 4 | 1.4e-26 |
|
| 5 | 2e-11 |
|
| 6 | 3.9e-05 |
|
| 7 | 0.0014 |
|
| 8 | 0.029 |
|
| 9 | 9.5 |
|
| 10 | 17.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 8.8e-148 |
|
0.0 |
|
| 2 | 2.8e-119 |
|
7.3e-237 |
|
| 3 | 1.6e-98 |
|
1.3e-168 |
|
| 4 | 1.9e-70 |
|
4.8e-126 |
|
| 5 | 5.1e-15 |
|
1.8e-23 |
|
| 6 | 9.6e-11 |
|
9e-06 |
|
| 7 | 5.1e-05 |
|
0.059 |
|
| 8 | 0.28 |
|
1.0 |
|
| 9 | 1.7 |
|
87.0 |
|
| 10 | 72.0 |
|
96.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 7.5e-192 |
|
4.1e-254 |
|
| 2 | 8.6e-143 |
|
1.1e-270 |
|
| 3 | 7.7e-89 |
|
1.6e-131 |
|
| 4 | 4.7e-76 |
|
2.4e-119 |
|
| 5 | 1.7e-52 |
|
2.6e-76 |
|
| 6 | 1.5e-36 |
|
5.1e-45 |
|
| 7 | 2e-16 |
|
0.51 |
|
| 8 | 4.7e-07 |
|
800.0 |
|
| 9 | 180000.0 |
|
3600000.0 |
|
| 10 | 520000.0 |
|
4600000.0 |
|